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rashed shah

Thaker A A Alyousefi, Rashad Abdul-Ghani, Mohammed A K Mahdy, Samira M A Al-Eryani, Abdulsalam M Al-Mekhlafi, Yahia A Raja, Shamusul Azhar Shah, John C Beier
BACKGROUND: Yemen has witnessed several dengue fever outbreaks coincident with the social unrest and war in the country. The aim of the present study was to describe the knowledge, attitudes and practices (KAPs) of at-risk urban populations residing in Taiz, southwest of Yemen. In addition, factors possibly associated with poor preventive practices were investigated. METHODS: A household-based, cross-sectional survey was conducted in three urban districts encompassing 383 households...
October 7, 2016: BMC Infectious Diseases
Jessie Signorelli, Arpita Shah Gandhi
OBJECTIVE: To review and summarize data on cobimetinib, which was approved by the US Food and Drug Administration (FDA) in November 2015 for use in combination with vemurafenib for unresectable or metastatic melanoma with a BRAFV600E or V600K mutation. DATA SOURCES: A literature search using PubMed was conducted using the terms cobimetinib, MEK inhibitor, and melanoma from January 2000 to June 2016. STUDY SELECTION AND DATA EXTRACTION: The literature search was confined to human studies published in English...
October 3, 2016: Annals of Pharmacotherapy
Stephanie Mlacker, Golsa Shafa, Adam S Aldahan, Vidhi V Shah, Sahal Samarkandy, Keyvan Nouri
BACKGROUND: Zika virus (ZIKV) is an arbovirus within the Flaviviridae family, the recent spread of which has promoted public concern. METHODS: This study outlines the clinical features, potential for teratogenicity, diagnosis, and treatment of ZIKV infection. RESULTS: Zika virus is transmitted through the bite of an infected Stegomyia (= Aedes) mosquito, blood transfusion, sexual intercourse, and perinatal routes. Infection has been characterized as mildly symptomatic...
September 21, 2016: International Journal of Dermatology
Amir Azarpazhooh, Herenia P Lawrence, Prakeshkumar S Shah
BACKGROUND: Acute otitis media (AOM) is the most common bacterial infection among young children in the United States. There are limitations and concerns over its treatment with antibiotics and surgery and so effective preventative measures are attractive. A potential preventative measure is xylitol, a natural sugar substitute that reduces the risk of dental decay. Xylitol can reduce the adherence of Streptococcus pneumoniae (S pneumoniae) and Haemophilus influenzae (H influenzae) to nasopharyngeal cells in vitro...
2016: Cochrane Database of Systematic Reviews
Mohammad Shahidul Islam, Samir K Saha, Maksuda Islam, Joyanta K Modak, Rashed Shah, Radwanur R Talukder, Shams El Arifeen, Abdullah H Baqui, Gary L Darmstadt, Luke C Mullany
BACKGROUND: Group B Streptococcus (GBS) is a predominant cause of early-onset neonatal sepsis (EOS) globally; however, the impact of this organism on the health of newborns in South Asia is debated, due in part to a paucity of community-based assessments. We estimated the prevalence and serotypes of GBS colonization of the umbilical cord stump, and the association of colonization with mortality in a population-based cohort of newborns in rural Sylhet District, Bangladesh. METHODS: Umbilical cord swabs were collected from 646 newborns up to three times within the first week after birth (ages <24 hours, ~3 days, ~6 days) and processed to identify GBS serotypes...
July 22, 2016: Pediatric Infectious Disease Journal
Dina Radenkovic, Shrinal Kotecha, Shreena Patel, Anjali Lakhani, Katharina Reimann-Dubbers, Shreya Shah, Daniyal Jafree, Stefan Mitrasinovic, Melissa Whitten
Previous qualitative studies suggest a lack of maternal confidence in care of their newborn child upon discharge into the community. This observation was supported by discussion with healthcare professionals and mothers at University College London Hospital (UCLH), highlighting specific areas of concern, in particular identifying and managing common neonatal presentations. The aim of this study was to design and introduce a checklist, addressing concerns, to increase maternal confidence in care of their newborn child...
2016: BMJ Quality Improvement Reports
Ankit Shah, Anil Kumar
In view of the recent outbreak of Zika virus (ZIKV), there is an urgent need to investigate the pathogenesis of the symptoms associated with ZIKV infection. Since the first identification of the virus in 1947, the pathologies associated with ZIKV infection were thought to be limited with mild illness that presented fever, rashes, muscle aches, and weakness. However, ZIKV infection has been shown to cause Guillain-Barré Syndrome, and numerous cases of congenital microcephaly in children have been reported when pregnant females were exposed to the virus...
August 2016: Neurotoxicity Research
Xiao Li, Josh Golubovsky, Joyce Hui-Yuen, Ummara Shah, Ewa Olech, Rosalia Lomeo, Vijay Singh, Howard Busch, Mary Jane Strandberg, Kayla Strandberg, Leslie Horowitz, Anca Askanase
OBJECTIVES: Acthar Gel is a long-acting formulation of adrenocorticotropic hormone (ACTH) with anti-inflammatory effects thought to be mediated in part through melanocortin receptor activation. This study was initiated to understand the role of Acthar Gel in SLE treatment in rheumatology practices. METHODS: This is a retrospective case series of nine adult female patients treated with Acthar Gel for at least six months at five academic centers. Treating physicians completed a one-page questionnaire on lupus medications, disease activity, and outcomes...
2015: F1000Research
K B Patel, H P Panchal, A B Karanwal, B B Parekh, S Shah, S Prasad
BACKGROUND: The 5-year survival rate for metastatic renal cell carcinoma (RCC) is estimated to be <10%. RCC is highly resistant to chemotherapy. Targeted agents are now first choice of therapy for metastatic RCC such as sunitinib and sorafenib. METHODS: This study is a retrospective analysis of 15 patients having metastatic RCC treated with sunitinib. Apart from three patients, all had clear cell histology. Thirteen patients received dosage of 50 mg/d (4 weeks on/2 weeks off cycles)...
January 2016: Indian Journal of Cancer
Jeffrey H Lipton, Charles Chuah, Agnès Guerci-Bresler, Gianantonio Rosti, David Simpson, Sarit Assouline, Gabriel Etienne, Franck E Nicolini, Philipp le Coutre, Richard E Clark, Leif Stenke, David Andorsky, Vivian Oehler, Stephanie Lustgarten, Victor M Rivera, Timothy Clackson, Frank G Haluska, Michele Baccarani, Jorge E Cortes, François Guilhot, Andreas Hochhaus, Timothy Hughes, Hagop M Kantarjian, Neil P Shah, Moshe Talpaz, Michael W Deininger
BACKGROUND: Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated with arterial occlusion. We investigated whether this activity and safety profile would result in superior outcomes compared with imatinib in previously untreated patients with chronic myeloid leukaemia. METHODS: The Evaluation of Ponatinib versus Imatinib in Chronic Myeloid Leukemia (EPIC) study was a randomised, open-label, phase 3 trial designed to assess the efficacy and safety of ponatinib, compared with imatinib, in newly diagnosed patients with chronic-phase chronic myeloid leukaemia...
May 2016: Lancet Oncology
J Ruan, B Shah, P Martin, S J Schuster
Lenalidomide is an oral immunomodulatory drug with significant activity in indolent B-cell and mantle cell lymphomas. Lenalidomide has a manageable safety profile whether administered as a single agent or in combination with rituximab. The combination of lenalidomide with rituximab, known as the 'R(2)' regimen, enhances efficacy over what has been shown with monotherapy and has demonstrated activity in patients considered resistant to rituximab. Tolerability of these regimens has been consistent among studies...
July 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Seon Young Choi, Shah M Rashed, Nur A Hasan, Munirul Alam, Tarequl Islam, Abdus Sadique, Fatema-Tuz Johura, Mark Eppinger, Jacques Ravel, Anwar Huq, Alejandro Cravioto, Rita R Colwell
UNLABELLED: An outbreak of cholera occurred in 1991 in Mexico, where it had not been reported for more than a century and is now endemic. Vibrio cholerae O1 prototype El Tor and classical strains coexist with altered El Tor strains (1991 to 1997). Nontoxigenic (CTX(-)) V. cholerae El Tor dominated toxigenic (CTX(+)) strains (2001 to 2003), but V. cholerae CTX(+) variant El Tor was isolated during 2004 to 2008, outcompeting CTX(-) V. cholerae. Genomes of six Mexican V. cholerae O1 strains isolated during 1991 to 2008 were sequenced and compared with both contemporary and archived strains of V...
2016: MBio
Rojina Shrestha, Narayan Dutt Pant, Ganga Gc, Srinivas Thapa, Biswas Neupane, Yogendra Shah, Ishan Gautam, Basu Dev Pandey
A descriptive cross-sectional study was carried out among 264 suspected dengue patients in two districts (Dang and Chitwan) of Nepal from June 2013 to November 2013. The anti-dengue IgM positivity was found to be (51/264)19.31% by capture ELISA, of which 21 (41.2%) were male and 30 (58.8%) were female. Symptoms of seropositive cases were fever, anorexia, nausea, headache, retro-orbital pain, skin rashes, and myalgia. Hematological features like thrombocytopenia and leucopenia were found to be significantly associated with the dengue fever (DF)...
2016: PloS One
H Roger Brown, Stephen Castellino, M Reid Groseclose, Chandikumar S Elangbam, Kathryn Mellon-Kusibab, Lawrence W Yoon, Lisa D Gates, David L Krull, Neal F Cariello, Leigh Arrington-Brown, Tony Tillman, Serita Fowler, Vishal Shah, David Bailey, Richard T Miller
Nevirapine (NVP) is associated with hepatotoxicity in 1-5% of patients. In rodent studies, NVP has been shown to cause hepatic enzyme induction, centrilobular hypertrophy, and skin rash in various rat strains but not liver toxicity. In an effort to understand whether NVP is metabolized differently in a transiently inflamed liver and whether a heightened immune response alters NVP-induced hepatic responses, female brown Norway rats were dosed with either vehicle or NVP alone (75 mg/kg/day for 15 days) or galactosamine alone (single intraperitoneal [ip] injection on day 7 to mimic viral hepatitis) or a combination of NVP (75/100/150 mg/kg/day for 15 days) and galactosamine (single 750 mg/kg ip on day 7)...
January 2016: Toxicologic Pathology
Hemant Thacker, Manish Shah, Rahul Tulle
DRESS Syndrome is caused by exposure to certain medications that may cause fever, rash, inflammation of internal organs, lymphadenopathy and characteristic hematologic abnormalities such as eosinophilia, thrombocytopenia and atypical lymphocytosis. We herein report a case of DRESS syndrome who presented with fever and rash, secondary to sulfasalazine ingestion. Diagnosis of DRESS is often delayed, as several diseases have clinical and laboratory features similar to DRESS syndrome.
May 2015: Journal of the Association of Physicians of India
Ruben Magni, Benjamin H Espina, Ketul Shah, Benjamin Lepene, Christine Mayuga, Temple A Douglas, Virginia Espina, Sally Rucker, Ross Dunlap, Emanuel F Iii Petricoin, Mary Frekko Kilavos, Donald M Poretz, Gilbert R Irwin, Samuel M Shor, Lance A Liotta, Alessandra Luchini
OBJECTIVES: Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust serology response. Using a novel analyte harvesting nanotechnology, Nanotrap particles, we evaluated urinary Borrelia Outer surface protein A (OspA) C-terminus peptide in early stage LB before and after treatment, and in patients suspected of late stage disseminated LB...
2015: Journal of Translational Medicine
Jia Ruan, Peter Martin, Bijal Shah, Stephen J Schuster, Sonali M Smith, Richard R Furman, Paul Christos, Amelyn Rodriguez, Jakub Svoboda, Jessica Lewis, Orel Katz, Morton Coleman, John P Leonard
BACKGROUND: Mantle-cell lymphoma is generally incurable. Initial treatment is not standardized but usually includes cytotoxic chemotherapy. Lenalidomide, an immunomodulatory compound, and rituximab, an anti-CD20 antibody, are active in patients with recurrent mantle-cell lymphoma. We evaluated lenalidomide plus rituximab as a first-line therapy. METHODS: We conducted a single-group, multicenter, phase 2 study with induction and maintenance phases. During the induction phase, lenalidomide was administered at a dose of 20 mg daily on days 1 through 21 of every 28-day cycle for 12 cycles; the dose was escalated to 25 mg daily after the first cycle if no dose-limiting adverse events occurred during the first cycle and was reduced to 15 mg daily during the maintenance phase...
November 5, 2015: New England Journal of Medicine
Mahamud-ur Rashid, Shah M Rashed, Tarequl Islam, Fatema-Tuz Johura, Haruo Watanabe, Makoto Ohnishi, Munirul Alam
No abstract text is available yet for this article.
January 2016: Journal of Medical Microbiology
Pirunthan Pathmarajah, Karishma Shah, Kathy Taghipour, Su Ramachandra, Mangesh A Thorat, Ziaullah Chaudhry, Vivek Patkar, Francesca Peters, Thomas Connor, Emma Spurrell, Jeffrey S Tobias, Jayant S Vaidya
INTRODUCTION: Letrozole, an aromatase inhibitor, is a commonly used neo-adjuvant drug to treat hormone-sensitive breast cancer. There have been a few cases of aromatase inhibitor induced vasculitis but the first case of letrozole-induced vasculitis was reported from Switzerland in 2014 (Digklia et al.) [1]. PRESENTATION OF CASE: We report the case of a 72-year-old woman with a small breast cancer. She was started on pre-operative letrozole (2.5mg/d) whilst awaiting surgery...
2015: International Journal of Surgery Case Reports
Eleni Volonaki, Mohamed Mutalib, Fevronia Kiparissi, Neil Shah, Keith J Lindley, Mamoun Elawad
AIM: The role of adalimumab in medically refractory ulcerative colitis (UC) in children remains to be defined. The aim of this study was to describe 11 cases of paediatric patients who received adalimumab as a second-line anti-TNF-α treatment for paediatric UC. METHODS: A retrospective review of all patients with UC who received adalimumab between April 2008 and October 2013 at our hospital was conducted. Clinical efficacy and safety were assessed. RESULTS: Eleven patients (three boys, eight girls) with a median age of 13...
December 2015: European Journal of Gastroenterology & Hepatology
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