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JOURNAL ARTICLE
Amarnath Rambhatla, Rupin Shah, Imad Ziouziou, Priyank Kothari, Gianmaria Salvio, Murat Gul, Taha Hamoda, Parviz Kavoussi, Widi Atmoko, Tuncay Toprak, Ponco Birowo, Edmund Ko, Mohamed Arafa, Ramy Abou Ghayda, Vilvapathy Senguttuvan Karthikeyan, Giorgio Ivan Russo, Germar-Michael Pinggera, Eric Chung, Ahmed M Harraz, Marlon Martinez, Nguyen Ho Vinh Phuoc, Nicholas Tadros, Ramadan Saleh, Missy Savira, Giovanni M Colpi, Wael Zohdy, Edoardo Pescatori, Hyun Jun Park, Shinichiro Fukuhara, Akira Tsujimura, Cesar Rojas-Cruz, Angelo Marino, Siu King Mak, Edouard Amar, Wael Ibrahim, Puneet Sindhwani, Naif Alhathal, Gian Maria Busetto, Manaf Al Hashimi, Ahmed El-Sakka, Asci Ramazan, Fotios Dimitriadis, Massimiliano Timpano, Davor Jezek, Baris Altay, Daniel Suslik Zylbersztejn, Michael Yc Wong, Du Geon Moon, Christine Wyns, Safar Gamidov, Hamed Akhavizadegan, Alessandro Franceschelli, Kaan Aydos, Nguyen Quang, Shedeed Ashour, Adel Al Dayel, Mohammed S Al-Marhoon, Sava Micic, Saleh Binsaleh, Alayman Hussein, Haitham Elbardisi, Taymour Mostafa, Jonathan Ramsay, Athanasios Zachariou, Islam Fathy Soliman Abdelrahman, Osvaldo Rajmil, Arif Kalkanli, Juan Manuel Corral Molina, Kadir Bocu, Gede Wirya Kusuma Duarsa, Gökhan Çeker, Ege Can Serefoglu, Fahmi Bahar, Nazim Gherabi, Shinnosuke Kuroda, Abderrazak Bouzouita, Ahmet Gudeloglu, Erman Ceyhan, Mohamed Saeed Mohamed Hasan, Muhammad Ujudud Musa, Ahmad Motawi, Chak-Lam Cho, Hisanori Taniguchi, Christopher Chee Kong Ho, Jesus Fernando Solorzano Vazquez, Shingai Mutambirwa, Nur Dokuzeylul Gungor, Marion Bendayan, Carlo Giulioni, Aykut Baser, Marco Falcone, Luca Boeri, Gideon Blecher, Alireza Kheradmand, Tamilselvi Sethupathy, Ricky Adriansjah, Nima Narimani, Charalampos Konstantinidis, Tuan Thanh Nguyen, Andrian Japari, Parisa Dolati, Keerti Singh, Cevahir Ozer, Selcuk Sarikaya, Nadia Sheibak, Ndagijimana Jean Bosco, Mehmet Serkan Özkent, Sang Thanh Le, Ioannis Sokolakis, Darren Katz, Ryan Smith, Manh Nguyen Truong, Tan V Le, Zhongwei Huang, Muslim Dogan Deger, Umut Arslan, Gokhan Calik, Giorgio Franco, Ayman Rashed, Oguzhan Kahraman, Sotiris Andreadakis, Rosadi Putra, Giancarlo Balercia, Kareim Khalafalla, Rossella Cannarella, Anh Ðăng Tuân, Amr El Meliegy, Birute Zilaitiene, Marlene Lizbeth Zamora Ramirez, Filippo Giacone, Aldo E Calogero, Konstantinos Makarounis, Sunil Jindal, Bac Nguyen Hoai, Ravi Banthia, Marcelo Rodriguez Peña, Dharani Moorthy, Aram Adamyan, Deniz Kulaksiz, Hussein Kandil, Nikolaos Sofikitis, Ciro Salzano, Andreas Jungwirth, Surendra Reddy Banka, Tiago Cesar Mierzwa, Tahsin Turunç, Divyanu Jain, Armen Avoyan, Pietro Salacone, Ateş Kadıoğlu, Chirag Gupta, Haocheng Lin, Iman Shamohammadi, Nasser Mogharabian, Trenton Barrett, Yavuz Onur Danacıoğlu, Andrea Crafa, Salima Daoud, Vineet Malhotra, Abdulmalik Almardawi, Osama Mohamed Selim, Mohamad Moussa, Saeid Haghdani, Mesut Berkan Duran, Yannic Kunz, Mirko Preto, Elena Eugeni, Thang Nguyen, Ahmed Rashad Elshahid, Seso Sulijaya Suyono, Dyandra Parikesit, Essam Nada, Eduardo Gutiérrez Orozco, Florence Boitrelle, Nguyen Thi Minh Trang, Mounir Jamali, Raju Nair, Mikhail Ruzaev, Franco Gadda, Charalampos Thomas, Raphael Henrique Ferreira, Umit Gul, Serena Maruccia, Ajay Kanbur, Ella Kinzikeeva, Saad Mohammed Abumelha, Raghavender Kosgi, Fatih Gokalp, Mohammad Ayodhia Soebadi, Gustavo Marquesine Paul, Hesamoddin Sajadi, Deepak Gupte, Rafael F Ambar, Emrullah Sogutdelen, Karun Singla, Ari Basukarno, Shannon Hee Kyung Kim, Mohammad Ali Sadighi Gilani, Koichi Nagao, Sakti Ronggowardhana Brodjonegoro, Andri Rezano, Mohamed Elkhouly, Rossella Mazzilli, Hasan M A Farsi, Hung Nguyen Ba, Hamed Alali, Dimitrios Kafetzis, Tran Quang Tien Long, Sami Alsaid, Hoang Bao Ngoc Cuong, Knigavko Oleksandr, Akhmad Mustafa, Herik Acosta, Hrishikesh Pai, Bahadır Şahin, Eko Arianto, Colin Teo, Sanjay Prakash Jayaprakash, Rinaldo Indra Rachman, Mustafa Gurkan Yenice, Omar Sefrioui, Shivam Priyadarshi, Marko Tanic, Noor Kareem Alfatlaw, Fikri Rizaldi, Ranjit B Vishwakarma, George Kanakis, Dinesh Thomas Cherian, Joe Lee, Raisa Galstyan, Hakan Keskin, Janan Wurzacher, Doddy Hami Seno, Bambang S Noegroho, Ria Margiana, Qaisar Javed, Fabrizio Castiglioni, Raman Tanwar, Ana Puigvert, Coşkun Kaya, Medianto Purnomo, Chadi Yazbeck, Azwar Amir, Edson Borges, Marina Bellavia, Isaac Ardianson Deswanto, Vinod Kv, Giovanni Liguori, Dang Hoang Minh, Kashif Siddiqi, Fulvio Colombo, Armand Zini, Niket Patel, Selahittin Çayan, Ula Al-Kawaz, Maged Ragab, Guadalupe Hernández Hebrard, Jean de la Rosette, Ozan Efesoy, Ivan Hoffmann, Thiago Afonso Teixeira, Barış Saylam, Daniela Delgadillo, Ashok Agarwal
PURPOSE: Non-obstructive azoospermia (NOA) is a common, but complex problem, with multiple therapeutic options and a lack of clear guidelines. Hence, there is considerable controversy and marked variation in the management of NOA. This survey evaluates contemporary global practices related to medical and surgical management for patients with NOA. MATERIALS AND METHODS: A 56-question online survey covering various aspects of the evaluation and management of NOA was sent to specialists around the globe...
April 4, 2024: World Journal of Men's Health
#2
JOURNAL ARTICLE
Rupin Shah, Amarnath Rambhatla, Widi Atmoko, Marlon Martinez, Imad Ziouziou, Priyank Kothari, Nicholas Tadros, Nguyen Ho Vinh Phuoc, Parviz Kavoussi, Ahmed Harraz, Gianmaria Salvio, Murat Gul, Taha Hamoda, Tuncay Toprak, Ponco Birowo, Edmund Ko, Mohamed Arafa, Ramy Abou Ghayda, Vilvapathy Senguttuvan Karthikeyan, Ramadan Saleh, Giorgio Ivan Russo, Germar-Michael Pinggera, Eric Chung, Missy Savira, Giovanni M Colpi, Wael Zohdy, Edoardo Pescatori, Hyun Jun Park, Shinichiro Fukuhara, Akira Tsujimura, Cesar Rojas-Cruz, Angelo Marino, Siu King Mak, Edouard Amar, Wael Ibrahim, Puneet Sindhwani, Naif Alhathal, Gian Maria Busetto, Manaf Al Hashimi, Ahmed El-Sakka, Asci Ramazan, Fotios Dimitriadis, Massimiliano Timpano, Davor Jezek, Baris Altay, Daniel Suslik Zylbersztejn, Michael Yc Wong, Du Geon Moon, Christine Wyns, Safar Gamidov, Hamed Akhavizadegan, Alessandro Franceschelli, Kaan Aydos, Vinh Nguyen Quang, Shedeed Ashour, Adel Al Dayel, Mohamed S Al-Marhoon, Sava Micic, Saleh Binsaleh, Alayman Hussein, Haitham Elbardisi, Taymour Mostafa, Emad Taha, Jonathan Ramsay, Athanasios Zachariou, Islam Fathy Soliman Abdelrahman, Osvaldo Rajmil, Arif Kalkanli, Juan Manuel Corral Molina, Kadir Bocu, Gede Wirya Kusuma Duarsa, Gokhan Ceker, Ege Can Serefoglu, Fahmi Bahar, Nazim Gherabi, Shinnosuke Kuroda, Abderrazak Bouzouita, Ahmet Gudeloglu, Erman Ceyhan, Mohamed Saeed Mohamed Hasan, Muhammad Ujudud Musa, Ahmad Motawi, Cho Chak-Lam, Hisanori Taniguchi, Christopher Chee Kong Ho, Jesus Fernando Solorzano Vazquez, Shingai Mutambirwa, Nur Dokuzeylul Gungor, Marion Bendayan, Carlo Giulioni, Aykut Baser, Marco Falcone, Luca Boeri, Gideon Blecher, Alireza Kheradmand, Tamilselvi Sethupathy, Ricky Adriansjah, Nima Narimani, Charalampos Konstantinidis, Tuan Thanh Nguyen, Andrian Japari, Parisa Dolati, Keerti Singh, Cevahir Ozer, Selcuk Sarikaya, Nadia Sheibak, Ndagijimana Jean Bosco, Mehmet Serkan Özkent, Sang Thanh Le, Ioannis Sokolakis, Darren Katz, Ryan Smith, Manh Nguyen Truong, Tan V Le, Zhongwei Huang, Muslim Dogan Deger, Umut Arslan, Gokhan Calik, Giorgio Franco, Ayman Rashed, Oguzhan Kahraman, Sotiris Andreadakis, Rosadi Putra, Giancarlo Balercia, Kareim Khalafalla, Rossella Cannarella, Anh Ðăng Tuân, Amr El Meliegy, Birute Zilaitiene, Marlene Lizbeth Zamora Ramirez, Filippo Giacone, Aldo E Calogero, Konstantinos Makarounis, Sunil Jindal, Bac Nguyen Hoai, Ravi Banthia, Marcelo Rodriguez Peña, Dharani Moorthy, Aram Adamyan, Deniz Kulaksiz, Hussein Kandil, Nikolaos Sofikitis, Ciro Salzano, Andreas Jungwirth, Surendra Reddy Banka, Tiago Cesar Mierzwa, Tahsin Turunç, Divyanu Jain, Armen Avoyan, Pietro Salacone, Ateş Kadıoğlu, Chirag Gupta, Haocheng Lin, Iman Shamohammadi, Nasser Mogharabian, Trenton Barrett, Yavuz Onur Danacıoğlu, Andrea Crafa, Salima Daoud, Vineet Malhotra, Abdulmalik Almardawi, Osama Mohamed Selim, Mohamad Moussa, Saeid Haghdani, Mesut Berkan Duran, Yannic Kunz, Mirko Preto, Elena Eugeni, Thang Nguyen, Ahmed Rashad Elshahid, Seso Sulijaya Suyono, Dyandra Parikesit, Essam Nada, Eduardo Gutiérrez Orozco, Florence Boitrelle, Nguyen Thi Minh Trang, Mounir Jamali, Raju Nair, Mikhail Ruzaev, Franco Gadda, Charalampos Thomas, Raphael Henrique Ferreira, Umit Gul, Serena Maruccia, Ajay Kanbur, Ella Kinzikeeva, Saad Abumelha, Nguyen Quang, Raghavender Kosgi, Fatih Gokalp, Mohammad Ayodhia Soebadi, Gustavo Marquesine Paul, Hesamoddin Sajadi, Deepak Gupte, Rafael F Ambar, Emrullah Sogutdelen, Karun Singla, Ari Basurkano, Shannon Hee Kyung Kim, Mohammad Ali Sadighi Gilani, Koichi Nagao, Sakti Ronggowardhana Brodjonegoro, Andri Rezano, Mohamed Elkhouly, Rossella Mazzilli, Hasan M A Farsi, Hung Nguyen Ba, Hamed Alali, Dimitrios Kafetzis, Tran Quang Tien Long, Sami Alsaid, Hoang Bao Ngoc Cuong, Knigavko Oleksandr, Akhmad Mustafa, Herik Acosta, Hrishikesh Pai, Bahadır Şahin, Eko Arianto, Colin Teo, Sanjay Prakash Jayaprakash, Rinaldo Indra Rachman, Mustafa Gurkan Yenice, Omar Sefrioui, Smit Paghdar, Shivam Priyadarshi, Marko Tanic, Noor Kareem Alfatlawy, Fikri Rizaldi, Ranjit B Vishwakarma, George Kanakis, Dinesh Thomas Cherian, Joe Lee, Raisa Galstyan, Hakan Keskin, Jana Wurzacher, Doddy Hami Seno, Bambang S Noegroho, Ria Margiana, Qaisar Javed, Fabrizio Castiglioni, Raman Tanwar, Ana Puigvert, Coşkun Kaya, Medianto Purnomo, Chadi Yazbeck, Azwar Amir, Edson Borges, Marina Bellavia, Isaac Ardianson Deswanto, Vinod K V, Giovanni Liguori, Dang Hoang Minh, Kashif Siddiqi, Fulvio Colombo, Armand Zini, Niket Patel, Selahittin Çayan, Ula Al-Kawaz, Maged Ragab, Charalampos Konstantinidis, Guadalupe Hernández Hebrard, Ivan Hoffmann, Ozan Efesoy, Barış Saylam, Ashok Agarwal
PURPOSE: Non-obstructive azoospermia (NOA) represents the persistent absence of sperm in ejaculate without obstruction, stemming from diverse disease processes. This survey explores global practices in NOA diagnosis, comparing them with guidelines and offering expert recommendations. MATERIALS AND METHODS: A 56-item questionnaire survey on NOA diagnosis and management was conducted globally from July to September 2022. This paper focuses on part 1, evaluating NOA diagnosis...
April 3, 2024: World Journal of Men's Health
#3
JOURNAL ARTICLE
Sehar Rasool, Haifa A S Alhaithloul, Sobia Shahzad, Fahd Rasul, Wang Lihong, Adnan Noor Shah, Muhammad Nawaz, Asif Ghafoor, Muhammad Aamer, Muhammad Umair Hassan, Sezai Ercisli, Rayan S Alharbi, Afaf A Rashed, Sameer H Qari
The increased concentration of lead (Pb) in soils is a serious threat to human beings and plants all over the world. Salinity stress is also a major issue across the globe, which limits crop productivity. The use of allelochemicals has become an effective strategy to mitigate the toxic effects of abiotic stresses. Sorghum is an important crop grown across the globe, and it also possesses an appreciably allelopathic potential. Therefore, this study was planned to determine the impacts of the sorghum water extract (SWE) on improving maize growth under Pb and salinity stress...
March 19, 2024: ACS Omega
#4
MULTICENTER STUDY
Ahmed A H H Nasser, Manpreet Sidhu, Rohan Prakash, Ansar Mahmood, Khabab Osman, Govind S Chauhan, Rajpal Nandra, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balasubramanian Balakumar, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled M Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad A Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
AIMS: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. METHODS: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality...
February 1, 2024: Bone & Joint Journal
#5
JOURNAL ARTICLE
Vanita Noronha, Nandini S Menon, Vijay Maruti Patil, M V Chandrakanth, Sucheta More, Aditya Dhanawat, Oindrila Roy Chowdhary, Ajaykumar Chandrabhan Singh, Supriya Goud, Srushti Shah, Naveen Karuvandan, Kunal Naishadh Jobanputra, Darshit Kalpeshkumar Shah, Minit Jalan Shah, Rupjyoti Sarma, Dhwaniben Patel, Ritam Joarder, Prashant Kumar, Anupa John, Jaspreet Kaur, Saurabh Bagra, Nilendu Purandare, Amit Janu, Abhishek Mahajan, Kumar Prabhash
INTRODUCTION: The outcomes in advanced NSCLC have improved owing to the availability of more effective systemic and improved supportive care. This has increased the number of patients who seek treatment in the third line and beyond setting. We conducted this study to compare the quality of life (QoL), toxicity, and outcomes in patients receiving chemotherapy and EGFR tyrosine kinase inhibitors (TKIs) in this setting. METHODS: In this phase 3, randomized, open-label study, patients with stage III or IV NSCLC with disease progression on at least two prior lines of chemotherapy, with a life expectancy of at least 3 months, without prior EGFR TKI exposure, and stable brain metastases (if any) were included...
January 2024: JTO clinical and research reports
#6
JOURNAL ARTICLE
Rossella Cannarella, Rupin Shah, Ramadan Saleh, Florence Boitrelle, Taha Abo-Almagd Abdel-Meguid Hamoda, Rajender Singh, Gianmaria Salvio, Tuncay Toprak, Marco Falcone, Murat Gul, Fotios Dimitriadis, Amarnath Rambhatla, Giorgio I Russo, Edmund Ko, Armand Zini, Parviz Kavoussi, Nguyen Ho Vinh Phuoc, Hussein Kandil, Ramy Abou Ghayda, Ponco Birowo, Nazim Gherabi, Erman Ceyhan, Jie Dong, Vineet Malhotra, Damayanthi Durairajanayagam, Bircan Kolbasi, Fahmi Bahar, Gokhan Calik, Selahittin Çayan, Germar-Michael Pinggera, Aldo E Calogero, Osvaldo Rajmil, Taymour Mostafa, Widi Atmoko, Ahmed M Harraz, Tan V Le, Jean de la Rosette, Lukman Hakim, Edoardo Pescatori, Oleg Sergeyev, Ayman Rashed, Pallavi Saini, Ashok Agarwal
PURPOSE: Varicoceles can be a source of elevated seminal oxidative stress (OS) and sperm DNA fragmentation (SDF). However, it remains unclear whether varicocele repair (VR) could reduce these parameters. This systematic review and meta-analysis (SRMA) aims to investigate the impact of VR on SDF and seminal malondialdehyde (MDA). MATERIALS AND METHODS: A literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases. This SRMA included randomized controlled trials and observational studies reporting the pre- and postoperative levels of SDF and seminal OS in infertile men with clinical varicocele that underwent VR...
January 2, 2024: World Journal of Men's Health
#7
JOURNAL ARTICLE
Siti Aishah Baharuddin, Nor Nadiah Abd Karim Shah, Latifah Saiful Yazan, Aswir Abd Rashed, Kazunori Kadota, Alhussein M Al-Awaadh, Yus Aniza Yusof
Colorectal cancer (CRC) is the most common malignancy and the third primary cause of cancer-related mortalities caused by unhealthy diet, hectic lifestyle, and genetic damage. People aged ≥ 50 are more at risk for CRC. Nowadays, bioactive compounds from plants have been widely studied in preventing CRC because of their anticancer and antioxidant properties. Herein, ultrasound-assisted extraction (UAE) was used to extract the bioactive compounds of Pluchea indica (L.) leaves. The resultant total phenolic content (TPC) and total flavonoid content (TFC) of P...
November 23, 2023: Ultrasonics Sonochemistry
#8
JOURNAL ARTICLE
Anuradha J Punchihewage-Don, Nur A Hasan, Shah M Rashed, Salina Parveen
Investigating the chicken microbiome is important to establish control measures for pathogens to protect consumers. This study aimed at evaluating the comparative efficiency of human pathogen detection through 16S rRNA sequencing of organic and conventional chickens processed using whole carcass enrichment (WCE) and rinse (WCR) methods. Organic and conventional whole broiler carcasses (n=31) were vigorously shaken with 500 mL buffered peptone water (BPW). For the rinse method, a 30 mL aliquot was mixed with 30 mL of BPW...
October 5, 2023: Journal of Food Protection
#9
Ahmed Ali Aziz, Maleeha Saleem, Sara L Wallach, Shazia M Shah
Monkeypox (MPX) virus is endemic in Africa. However, since May 2022, many cases have been reported worldwide in many non-endemic regions as well. The virus usually spreads from animals to humans or from humans to humans through respiratory droplets or after contact with infected lesions. In the recent outbreak of MPX, many cases did not have any travel history to endemic areas and were reported in men who have sex with men (MSM) along with the diagnosis of other sexually transmitted diseases (STDs). However, MPX is not yet considered a sexually transmitted infection (STI), even though a relationship between MPX and other STIs may exist with a possible facilitating action on their spreading...
July 2023: Curēus
#10
Carine M Lama, Miguel A Hernandez-Rovira, Neha Mehta-Shah, Aaron Russell, Amy C M Musiek
No abstract text is available yet for this article.
August 2023: JAAD Case Reports
#11
JOURNAL ARTICLE
Lars H Lund, Carolyn S P Lam, Patricia E Pizzato, Anders Gabrielsen, Erik Michaëlsson, Karin Nelander, Hans Ericsson, Julie Holden, Folke Folkvaljon, Andrea Mattsson, Anna Collén, Malin Aurell, Carl Whatling, Stephan Baldus, Grzegorz Drelich, Assen Goudev, Béla Merkely, Niklas Bergh, Sanjiv J Shah
AIMS: Mitiperstat (formerly AZD4831) is a novel selective myeloperoxidase inhibitor. Currently, no effective therapies target comorbidity-induced systemic inflammation, which may be a key mechanism underlying heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). Circulating neutrophils secrete myeloperoxidase, causing oxidative stress, microvascular endothelial dysfunction, interstitial fibrosis, cardiomyocyte remodelling and diastolic dysfunction. Mitiperstat may therefore improve function of the heart and other organs, and ameliorate heart failure symptoms and exercise intolerance...
July 20, 2023: European Journal of Heart Failure
#12
JOURNAL ARTICLE
Katrina A Williamson, Mark Yun, Matthew J Koster, Courtney Arment, Asha Patnaik, Tara W Chang, Adam C Bledsoe, Sutthichai Sae-Tia, Aditya S Shah, Jonathan Samuels, John M Davis Iii, Qingping Yao
OBJECTIVES: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and contributes to defense against infection and inflammatory regulation. NOD2 mutations are associated with autoinflammatory diseases...
July 19, 2023: Rheumatology
#13
JOURNAL ARTICLE
Ibrahim Alissa, Anroop B Nair, Bandar Aldhubiab, Hiral Shah, Jigar Shah, Vivek Mewada, Rashed M Almuqbil, Shery Jacob
Clinical application of treprostinil in pulmonary arterial hypertension is hampered by adverse effects caused by its high dosing frequency. The objective of this investigation was to Formulate an adhesive-type transdermal patch of treprostinil and evaluate it both in vitro and in vivo. A 32 -factorial design was utilized to optimize the selected independent variables (X1 : drug amount, X2 : enhancer concentration) on the response variables (Y1 : drug release, Y2 : transdermal flux). The optimized patch was evaluated for various pharmaceutical properties, skin irritation, and pharmacokinetics in rats...
April 12, 2023: Pharmaceutics
#14
JOURNAL ARTICLE
Ahmed S Alnaim, Hiral Shah, Anroop B Nair, Vivek Mewada, Smit Patel, Shery Jacob, Bandar Aldhubiab, Mohamed A Morsy, Rashed M Almuqbil, Pottathil Shinu, Jigar Shah
Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes have been extensively investigated as a transdermal vesicular nanocarrier to increase the delivery of low permeable compounds into and across the skin. This research work was to design, develop and optimize levosulpiride-loaded niosomal gel and to evaluate its prospects for transdermal delivery. The Box-Behnken design was used to optimize niosomes by analyzing the impact of three factors (cholesterol; X1 , Span 40; X2 , and sonication time; X3 ) on the responses (particle size, Y1 , and entrapment efficiency, Y2 )...
March 10, 2023: Gels
#15
JOURNAL ARTICLE
Lauren B Yeager, Joseph M Grimes, Alexis K Dal Col, Nirav V Shah, Dmitry Bogomolny, Larisa Debelenko, Brian P Marr
PURPOSE: The authors aim to describe the ophthalmologic manifestations of pediatric Erdheim-Chester disease (ECD). METHODS: The authors describe a novel case of ECD presenting as isolated bilateral proptosis in a child and provide a comprehensive review of the documented pediatric cases to observe overall trends and ophthalmic manifestations of disease. Twenty pediatric cases were identified in the literature. RESULTS: The mean age at presentation was 9...
March 3, 2023: Ophthalmic Plastic and Reconstructive Surgery
#16
JOURNAL ARTICLE
Sandesh Rimal, Sabin Shrestha, Kishor Pandey, Thanh Vu Nguyen, Parmananda Bhandari, Yogendra Shah, Dhiraj Acharya, Nabaraj Adhikari, Komal Raj Rijal, Prakash Ghimire, Yuki Takamatsu, Basu Dev Pandey, Stefan Fernandez, Kouichi Morita, Mya Myat Ngwe Tun, Shyam Prakash Dumre
The largest dengue outbreak in the history of Nepal occurred in 2022, with a significant number of casualties. It affected all 77 districts, with the nation's capital, Kathmandu (altitude 1300 m), being the hardest hit. However, the molecular epidemiology of this outbreak, including the dengue virus (DENV) serotype(s) responsible for this epidemic, remain unknown. Here, we report the epidemic trends, clinico-laboratory features, and virus serotypes and their viral load profiles that are associated with this outbreak in Nepal...
February 11, 2023: Viruses
#17
JOURNAL ARTICLE
Anroop B Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M Almuqbil, Ahmed S Alnaim, Fatemah Alqattan, Jigar Shah
Dolutegravir's therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood-brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting of various drugs by intranasal delivery. Thus, the purpose of this study was to develop a Dolutegravir-loaded nanoemulsion-based in situ gel and evaluate its prospective for brain targeting by intranasal delivery. Dolutegravir-loaded nanoemulsions were prepared using dill oil, Tween® 80, and Transcutol® P...
February 3, 2023: Gels
#18
JOURNAL ARTICLE
Farhana Khanam, Md Taufiqul Islam, Faisal Ahmmed, Shams Uddin Ahmed, Md Ismail Hossen, MdNazmul Hasan Rajib, Shahinur Haque, Prasanta Kumar Biswas, Imam Tauheed, K Zaman, Ahmed Nawsher Alam, Mallick Masum Billah, Monalisa, Shah Ali Akbar Ashrafi, Mohammed Ziaur Rahman, Omar Hamza Bin Manjur, Mokibul Hassan Afrad, S M Shamsuzzaman, Ahmed Abu Saleh, Mostafa Aziz Sumon, Asif Rashed, Md Taufiqur Rahman Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Meerjady Sabrina Flora, Tahmina Shirin, John D Clemens, Firdausi Qadri
BACKGROUND: From May to December 2021, Bangladesh experienced a major surge in the Delta variant of SARS-CoV-2. The earlier rollout of several vaccines offered the opportunity to evaluate vaccine effectiveness against this variant. METHODS: A prospective, test-negative case-control study was conducted in five large hospitals in Dhaka between September and December 2021. The subjects were patients of at least 18 years of age who presented themselves for care, suffering COVID-like symptoms of less than 10 days' duration...
December 2, 2022: Vaccines
#19
JOURNAL ARTICLE
Christopher C Dvorak, Elie Haddad, Jennifer Heimall, Elizabeth Dunn, Rebecca H Buckley, Donald B Kohn, Morton J Cowan, Sung-Yun Pai, Linda M Griffith, Geoffrey D E Cuvelier, Hesham Eissa, Ami J Shah, Richard J O'Reilly, Michael A Pulsipher, Nicola A M Wright, Roshini S Abraham, Lisa Forbes Satter, Luigi D Notarangelo, Jennifer M Puck
Severe combined immunodeficiency (SCID) results from defects in the differentiation of hematopoietic stem cells into mature T lymphocytes, with additional lymphoid lineages affected in particular genotypes. In 2014, the Primary Immune Deficiency Treatment Consortium published criteria for diagnosing SCID, which are now revised to incorporate contemporary approaches. Patients with typical SCID must have less than 0.05 × 109 autologous T cells/L on repetitive testing, with either pathogenic variant(s) in a SCID-associated gene, very low/undetectable T-cell receptor excision circles or less than 20% of CD4 T cells expressing naive markers, and/or transplacental maternally engrafted T cells...
February 2023: Journal of Allergy and Clinical Immunology
#20
JOURNAL ARTICLE
Fatema-Tuz Johura, Sahitya Ranjan Biswas, Shah M Rashed, Mohammad Tarequl Islam, Saiful Islam, Marzia Sultana, Haruo Watanabe, Anwar Huq, Nicholas R Thomson, Rita R Colwell, Munirul Alam
Vibrio cholerae O1 El Tor, causative agent of the ongoing seventh cholera pandemic, is native to the aquatic environment of the Ganges Delta, Bay of Bengal (GDBB). Recent studies traced pandemic strains to the GDBB and proposed global spread of cholera had occurred via intercontinental transmission. In the research presented here, NotI-digested genomic DNA extracted from V. cholerae O1 clinical and environmental strains isolated in Bangladesh during 2004-2014 was analyzed by pulsed-field gel electrophoresis (PFGE)...
September 7, 2022: Infection, Genetics and Evolution
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