Christopher Kobylecki, Viorica Chelban, Yee Yen Goh, Emilia Michou, Riona Fumi, Marte Theilmann Jensen, Rahema Mohammad, Alyssa Costantini, Nirosen Vijiaratnam, Samantha Pavey, Nicola Pavese, P Nigel Leigh, James B Rowe, Michele T Hu, Alistair Church, Huw R Morris, Henry Houlden
BACKGROUND: Multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) show a high prevalence and rapid progression of dysphagia, which is associated with reduced survival. Despite this, the evidence base for gastrostomy is poor, and the optimal frequency and outcomes of this intervention are not known. We aimed to characterise the prevalence and outcomes of gastrostomy in patients with these three atypical parkinsonian disorders. METHOD: We analysed data from the natural history and longitudinal cohorts of the PROSPECT-M-UK study with up to 60 months of follow-up from baseline...
February 26, 2024: European Journal of Neurology