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https://www.readbyqxmd.com/read/27907809/does-exposure-to-phthalates-influence-thyroid-function-and-growth-hormone-homeostasis-the-taiwan-environmental-survey-for-toxicants-test-2013
#1
Han-Bin Huang, Wen-Harn Pan, Jung-Wei Chang, Hung-Che Chiang, Yue Leon Guo, Jouni J K Jaakkola, Po-Chin Huang
BACKGROUND: Previous epidemiologic and toxicological studies provide some inconsistent evidence that exposure to phthalates may affect thyroid function and growth hormone homeostasis. OBJECTIVE: To assess the relations between exposure to phthalates and indicators of thyroid function and growth hormone homeostasis disturbances both among adults and minors. METHODS: We conducted a population-based cross-sectional study of 279 Taiwanese adults (≥18 years old) and 79 minors (<18 years old) in 2013...
November 28, 2016: Environmental Research
https://www.readbyqxmd.com/read/27906594/the-relationship-between-thyroid-function-and-the-prevalence-of-type-2-diabetes-mellitus-in-euthyroid-subjects
#2
Yeqing Gu, Huihui Li, Xue Bao, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Huanmin Du, Hongbin Shi, Yang Xia, Qian Su, Liyun Fang, Fei Yu, Huijun Yang, Bin Yu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Qi Guo, Hong Chang, Guolin Wang, Guowei Huang, Kun Song, Kaijun Niu
PURPOSE: The thyroid hormones (TH) are primarily responsible for the regulation of energy balance and metabolism, suggesting that TH levels may contribute to the development of type 2 diabetes mellitus (T2DM). However, few studies have investigated the relationship between TH and T2DM in a general population. The aim of this study is to evaluate whether serum TH levels within the reference range are related to T2DM. METHODS: A cross-sectional study (n=15,296) was performed in Tianjin, China...
December 1, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27906195/congenital-hypothyroidism-with-delayed-thyroid-stimulating-hormone-elevation-in-premature-infants-born-at-less-than-30-weeks-gestation
#3
D C Kaluarachchi, T T Colaizy, L M Pesce, M Tansey, J M Klein
OBJECTIVE: Congenital hypothyroidism (CH) with delayed thyroid-stimulating hormone (TSH) elevation is a common form of thyroid dysfunction among premature infants. Routine newborn screening (NBS) may miss infants with CH with delayed TSH elevation. The objective of the study is to determine the prevalence of CH with delayed TSH elevation in premature infants and to identify associated risk factors. STUDY DESIGN: Retrospective analysis of serum thyroid function screening (TFS) at day of life 30 in premature infants <30 weeks gestation, admitted to University of Iowa Neonatal Intensive Care Unit between 1 July 2012 to 30 June 2015...
December 1, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27905199/high-prevalence-of-anti-tsh-receptor-antibody-in-fibromyalgia-syndrome
#4
Kenya Nishioka, Toyoyoshi Uchida, Chie Usui, Ryota Tanaka, Takashi Matsushima, Yoshifuji Matsumoto, Ikuro Nakamura, Kusuki Nishioka, Nobutaka Hattori
AIM: Fibromyalgia syndrome (FMS) is defined as chronic widespread pain that cannot be accounted for by any other medical disorder. Our aim was to explore the prevalence of thyroid autoimmunity in patients with FMS. METHODS: For determining thyroid function in 207 FMS patients, we tested for the titers of free tri-iodothyronine, free thyroxine, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TgAb) and anti-TSH receptor antibody (TRAb)...
November 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27905040/morphofunctional-changes-in-the-thyroid-gland-of-pubertal-and-postpubertal-rats-exposed-to-low-dose-of-ddt
#5
N V Yaglova, Yu P Sledneva, V V Yaglov
Consumption of low dose DDT from birth until puberty suppressed functional activity of the thyroid gland in rats and leads to destructive changes in the organ during the postpubertal period with compensatory stimulation of secretory activity of thyrocytes aimed at normalization of thyroxin production.
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27904073/a-case-of-familial-dysalbuminemic-hyperthyroxinemia-fdh-in-japan-fdh-as-a-possible-differential-diagnosis-of-syndrome-of-inappropriate-secretion-of-thyroid-stimulating-hormone-sitsh
#6
Sakiko Kobayashi, Jaeduk Yoshimura Noh, Taeko Shimizu, Tomoaki Sato, Isao Kurihara, Kiminori Sugino, Hiroshi Itoh, Koichi Ito
Familial dysalbuminemic hyperthyroxinemia (FDH) is an autosomal dominant condition and is the most commonly inherited euthyroid hyperthyroxinemia in Caucasians. However, it is extremely rare in Asian populations. A 30-year-old Japanese woman, who was incidentally found to have apparent thyroid dysfunction, was admitted to our hospital in 2004. She had extremely elevated serum free thyroxine (FT4), moderately elevated free triiodothyronine (FT3), and normal thyroid-stimulating hormone (TSH). Clinical thyroid examination revealed no abnormalities other than small goiter...
November 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27902923/kisspeptin-expression-is-decreased-in-the-arcuate-nucleus-of-hypothyroid-female-rats-with-irregular-estrus-cycles
#7
Yuji Tomori, Ken Takumi, Norio Iijima, Shinro Takai, Hitoshi Ozawa
Insufficiency of thyroid hormones inhibits gonadotropin release and results in dysregulation of reproductive function, although the precise mechanism of this disrupted gonadotropin secretion remains unclear. Kisspeptin is a neuropeptide that strongly stimulates gonadotropin secretion and plays an important role in reproductive function. To examine the involvement of kisspeptin in the dysregulation of gonadotropin secretion in hypothyroidism, we investigated Kiss1 mRNA expression and kisspeptin immunoreactivity in the hypothalamus of female rats treated with propylthiouracil (PTU)...
November 27, 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27901182/does-insulin-resistance-increase-thyroid-volume-in-patients-with-polycystic-ovary-syndrome
#8
Murat Sahin, Didem Demircioglu, Ayten Oguz, Dilek Tuzun, Mehmet Akif Sarica, Elif Inanc, Kamile Gul
Objective: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods: 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27892665/thyroid-function-after-postoperative-radiation-therapy-in-patients-with-breast-cancer
#9
Edyta Wolny-Rokicka, Andrzej Tukiendorf, Jerzy Wydmański, Danuta Roszkowska, Bogusław Staniul, Agnieszka Zembroń-Łacny
Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#10
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891281/septooptic-dysplasia-with-an-associated-arachnoid-cyst
#11
Skyler V McLaurin-Jiang, Julie K Wood, David F Crudo
A 4-week-old male infant presented with hypothermia, hypoglycemia, and hyperbilirubinemia. His medical history was remarkable for hydrocephalus secondary to an arachnoid cyst, intermittent hypoglycemia, hypothermia, and poor feeding requiring nasogastric tube for nutrition. Physical exam revealed retrognathia, mild hypotonia, micropenis, and clinodactyly. Ophthalmologic exam demonstrated bilateral optic nerve hypoplasia (ONH). Laboratory data confirmed inadequate cortisol and growth hormone response to hypoglycemia, a low thyroxine level, and direct hyperbilirubinemia...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27890823/assessment-of-thyroid-function-in-intensive-care-unit-patients-by-liquid-chromatography-tandem-mass-spectrometry-methods
#12
Kerry J Welsh, Brian R Stolze, Xiaolin Yu, Trisha R Podsiadlo, Lisa S Kim, Steven J Soldin
OBJECTIVES: Patients with non-thyroidal illness syndrome have many abnormalities in thyroid hormone tests. Such patients have medical comorbidities associated with low serum proteins and are on multiple medications that interfere with thyroid hormone measurement by immunoassay platforms. It is unknown if these thyroid hormone measurements reflect physiologic conditions or if they are artifacts of testing methodology. METHODS: Fifty patients were selected from the intensive care unit (ICU) from our institution...
November 24, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27884522/exposure-to-phthalates-in-children-aged-5-7years-associations-with-thyroid-function-and-insulin-like-growth-factors
#13
Wei Wu, Feng Zhou, Yue Wang, Yong Ning, Jian-Ye Yang, Yi-Kai Zhou
This study aimed to evaluate the associations between phthalate concentrations and thyroid function in preschool children. We collected demographic data and biological samples from 216 children aged 5-7years. We calculated urinary concentrations of eight mono-phthalate metabolites (mPAEs) separately for children from urban and rural areas and investigated their associations with thyroid function and growth hormones. mPAE concentrations were higher in children from the urban area than in those from the rural area, and most mPAEs were positively associated with free triiodothyronine and free thyroxine...
November 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27884404/exposure-to-perfluoroalkyl-substances-and-thyroid-function-in-pregnant-women-and-children-a-systematic-review-of-epidemiologic-studies
#14
REVIEW
Virginia Ballesteros, Olga Costa, Carmen Iñiguez, Tony Fletcher, Ferran Ballester, Maria-Jose Lopez-Espinosa
INTRODUCTION: Thyroid hormones (THs) are especially important for brain maturation and development during the fetal period and childhood. Several epidemiological studies have assessed the possible association between exposure to perfluoroalkyl substances (PFAS) and thyroid outcomes during the early stages of life. We aimed to review this evidence. METHODS: We conducted a systematic review in compliance with the PRISMA Statement (search conducted in PubMed and Embase, as well as in the citations of the selected articles)...
November 21, 2016: Environment International
https://www.readbyqxmd.com/read/27883023/a-comparison-of-the-performance-of-molecularly-imprinted-polymer-nanoparticles-for-small-molecule-targets-and-antibodies-in-the-elisa-format
#15
Katarzyna Smolinska-Kempisty, Antonio Guerreiro, Francesco Canfarotta, César Cáceres, Michael J Whitcombe, Sergey Piletsky
Here we show that molecularly imprinted polymer nanoparticles, prepared in aqueous media by solid phase synthesis with immobilised L-thyroxine, glucosamine, fumonisin B2 or biotin as template, can demonstrate comparable or better performance to commercially produced antibodies in enzyme-linked competitive assays. Imprinted nanoparticles-based assays showed detection limits in the pM range and polymer-coated microplates are stable to storage at room temperature for at least 1 month. No response to analyte was detected in control experiments with nanoparticles imprinted with an unrelated template (trypsin) but prepared with the same polymer composition...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882133/effects-of-forced-swimming-stress-on-thyroid-function-pituitary-thyroid-stimulating-hormone-and-hypothalamus-thyrotropin-releasing-hormone-expression-in-adrenalectomy-wistar-rats
#16
Qiuyan Sun, Aihua Liu, Yanan Ma, Anyi Wang, Xinhong Guo, Weiping Teng, Yaqiu Jiang
In order to study the impact that is imposed on the hypothalamic-pituitary-thyroid (HPT) axis of adrenalectomy male Wistar rats by stress caused by swimming, the blood level of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), the expression of TSHβ mRNA at the pituitary and thyrotropin releasing hormone (TRH) expression at the paraventricular nucleus (PVN) were measured. A total of 50 male Wistar rats of 6-8 weeks of age and with an average weight of 190-210 grams were randomly divided into the following two groups: The surgical (without adrenal glands) and non-surgical (adrenalectomy) group...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882089/gender-impact-on-the-correlation-between-thyroid-function-and-serum-lipids-in-patients-with-differentiated-thyroid-cancer
#17
Xue Li, Zhaowei Meng, Jian Tan, Ming Liu, Qiang Jia, Guizhi Zhang, Yajing He, Qing Zhang, Li Liu, Kun Song, Qing He, Mei Zhu, Shen Wang, Jianping Zhang, Wei Zheng, Renfei Wang, Tianpeng Hu, Na Liu, Arun Upadhyaya
The present study aimed to explore the association between thyroid stimulating hormone (TSH) and serum lipids in patients with differentiated thyroid cancer (DTC), with a focus on the risk of hyperlipidemia between different genders. The study included 352 DTC patients who were ready to receive I-131 therapy as well as 352 matched normal controls. In the DTC group, 157 patients were monitored for TSH and lipid parameters prior to and after 1 month of thyroxine therapy. Results were analyzed using t-tests, Pearson bivariate correlation and binary logistic regression analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27879691/overt-primary-hypothyroidism-in-an-industrial-area-in-s%C3%A3-o-paulo-brazil-the-impact-of-public-disclosure
#18
Maria Angela Zaccarelli-Marino, Carmen Diva Saldiva André, Julio M Singer
Background: Primary hypothyroidism (PH) is the most common thyroid pathology. Purpose: to evaluate the impact of public disclosure of an unexpected number of PH cases on the frequency of patients seeking medical evaluation for endocrinological diseases. Methods: data on 6306 subjects (3356 living in the surroundings of a petrochemical complex and 2950 in a control region) were collected over a 15-year time span. Thyroid function was determined by serum levels of triiodothyronine, thyroxine, free thyroxine and thyrotrophin...
November 22, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27867885/trimester-specific-reference-interval-for-thyroid-hormones-during-pregnancy-at-a-tertiary-care-hospital-in-haryana-india
#19
Rajesh Rajput, Bhagat Singh, Vasudha Goel, Amit Verma, Shashi Seth, Smiti Nanda
BACKGROUND: Reference intervals for thyroid hormone during pregnancy need to be gestational age, method, and population specific and there is need to establish trimester-specific thyroid levels for the different population across the world. The aim of this study was to establish trimester-specific reference range for thyroid hormone during pregnancy in a tertiary care center in Haryana. MATERIALS AND METHODS: A total of 1430 pregnant women were recruited for the study...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27864821/effect-of-alterations-in-apoptotic-pathway-on-development-of-metabolic-syndrome-in-patients-with-psoriasis-vulgaris
#20
S Korkmaz, H Korkmaz
OBJECTIVES: The purpose of this study is to evaluate the role of changes in gene expression of apoptosis activators (BAX, cytocrome-c [cyt-c], and caspase-3) and apoptosis inhibitors (BCL2, survivin, cyclin D1 [CCND1], SOD, catalase 3 [CAT], glutathione synthetase [GS], heat shock protein [HSP]27, HSP60, HSP70, and HSP90) on the development of metabolic syndrome (MetS) in patients with psoriasis vulgarins. METHODS: Fifty patients with psoriasis were enrolled in the study, 25 of whom had MetS...
November 18, 2016: British Journal of Dermatology
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