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dipak k mitra

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https://www.readbyqxmd.com/read/27843165/neonatal-mortality-within-24%C3%A2-hours-of-birth-in-six-low-and-lower-middle-income-countries
#1
Abdullah H Baqui, Dipak K Mitra, Nazma Begum, Lisa Hurt, Seyi Soremekun, Karen Edmond, Betty Kirkwood, Nita Bhandari, Sunita Taneja, Sarmila Mazumder, Muhammad Imran Nisar, Fyezah Jehan, Muhammad Ilyas, Murtaza Ali, Imran Ahmed, Shabina Ariff, Sajid B Soofi, Sunil Sazawal, Usha Dhingra, Arup Dutta, Said M Ali, Shaali M Ame, Katherine Semrau, Fern M Hamomba, Caroline Grogan, Davidson H Hamer, Rajiv Bahl, Sachiyo Yoshida, Alexander Manu
OBJECTIVE: To estimate neonatal mortality, particularly within 24 hours of birth, in six low- and lower-middle-income countries. METHODS: We analysed epidemiological data on a total of 149 570 live births collected between 2007 and 2013 in six prospective randomized trials and a cohort study from predominantly rural areas of Bangladesh, Ghana, India, Pakistan, the United Republic of Tanzania and Zambia. The neonatal mortality rate and mortality within 24 hours of birth were estimated for all countries and mortality within 6 hours was estimated for four countries with available data...
October 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27313070/validity-of-newborn-clinical-assessment-to-determine-gestational-age-in-bangladesh
#2
Anne Cc Lee, Luke C Mullany, Karima Ladhani, Jamal Uddin, Dipak Mitra, Parvez Ahmed, Parul Christian, Alain Labrique, Sushil K DasGupta, R Peter Lokken, Mohammed Quaiyum, Abdullah H Baqui
BACKGROUND: Gestational age (GA) is frequently unknown or inaccurate in pregnancies in low-income countries. Early identification of preterm infants may help link them to potentially life-saving interventions. METHODS: We conducted a validation study in a community-based birth cohort in rural Bangladesh. GA was determined by pregnancy ultrasound (<20 weeks). Community health workers conducted home visits (<72 hours) to assess physical/neuromuscular signs and measure anthropometrics...
July 2016: Pediatrics
https://www.readbyqxmd.com/read/27070072/infection-surveillance-protocol-for-a-multicountry-population-based-study-in-south-asia-to-determine-the-incidence-etiology-and-risk-factors-for-infections-among-young-infants-of-0-to-59-days-old
#3
Mohammad Shahidul Islam, Abdullah H Baqui, Anita K Zaidi, Zulfiqar A Bhutta, Pinaki Panigrahi, Anuradha Bose, Sajid B Soofi, Abdul Momin Kazi, Dipak K Mitra, Rita Isaac, Pritish Nanda, Nicholas E Connor, Daniel E Roth, Shamim A Qazi, Shams El Arifeen, Samir K Saha
BACKGROUND: Insufficient knowledge of the etiology and risk factors for community-acquired neonatal infection in low-income countries is a barrier to designing appropriate intervention strategies for these settings to reduce the burden and treatment of young infant infection. To address these gaps, we are conducting the Aetiology of Neonatal Infection in South Asia (ANISA) study among young infants in Bangladesh, India and Pakistan. The objectives of ANISA are to establish a comprehensive surveillance system for registering newborns in study catchment areas and collecting data on bacterial and viral etiology and associated risk factors for infections among young infants aged 0-59 days...
May 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27070066/implementation-of-the-anisa-protocol-in-sylhet-bangladesh-challenges-and-solutions
#4
Dipak K Mitra, Arif Mahmud, Nazma Begum, Iftekhar Rafiqullah, Arunangshu Roy, Syed Mamun Ibne Moin, Maksuda Islam, Md Abdul Quaiyum, Jannatul Ferdous, Jennifer A Applegate, Samir K Saha, Abdullah H Baqui
BACKGROUND: Despite the high rate of deaths in young infants (0-59 days) attributable to infections in resource-poor countries, data on bacterial and viral etiologies of community-acquired infections in this age group are limited. These data are needed to develop appropriate preventive strategies and suitable antibiotic treatment regimens for reducing the number of young infant deaths from infections. The Aetiology of Neonatal Infection in South Asia (ANISA) study is designed to generate these critical data and is being implemented in Bangladesh, India and Pakistan...
May 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26672742/anti-breast-tumor-activity-of-eclipta-extract-in-vitro-and-in-vivo-novel-evidence-of-endoplasmic-reticulum-specific-localization-of-hsp60-during-apoptosis
#5
Rakesh K Arya, Akhilesh Singh, Navneet K Yadav, Srikanth H Cheruvu, Zakir Hossain, Sanjeev Meena, Shrankhla Maheshwari, Anup K Singh, Uzma Shahab, Chetan Sharma, Kavita Singh, Tadigoppula Narender, Kalyan Mitra, Kamal R Arya, Rama K Singh, Jiaur R Gayen, Dipak Datta
Major challenges for current therapeutic strategies against breast cancer are associated with drug-induced toxicities. Considering the immense potential of bioactive phytochemicals to deliver non-toxic, efficient anti-cancer therapeutics, we performed bio-guided fractionation of Eclipta alba extract and discovered that particularly the chloroform fraction of Eclipta alba (CFEA) is selectively inducing cytotoxicity to breast cancer cells over non-tumorigenic breast epithelial cells. Our unbiased mechanistic hunt revealed that CFEA specifically activates the intrinsic apoptotic pathway by disrupting the mitochondrial membrane potential, upregulating Hsp60 and downregulating the expression of anti-apoptotic protein XIAP...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26643558/screening-and-treatment-of-maternal-genitourinary-tract-infections-in-early-pregnancy-to-prevent-preterm-birth-in-rural-sylhet-bangladesh-a-cluster-randomized-trial
#6
RANDOMIZED CONTROLLED TRIAL
Anne C C Lee, Mohammad A Quaiyum, Luke C Mullany, Dipak K Mitra, Alain Labrique, Parvez Ahmed, Jamal Uddin, Iftekhar Rafiqullah, Sushil DasGupta, Arif Mahmud, Emilia H Koumans, Parul Christian, Samir Saha, Abdullah H Baqui
BACKGROUND: Approximately half of preterm births are attributable to maternal infections, which are commonly undetected and untreated in low-income settings. Our primary aim is to determine the impact of early pregnancy screening and treatment of maternal genitourinary tract infections on the incidence of preterm live birth in Sylhet, Bangladesh. We will also assess the effect on other adverse pregnancy outcomes, including preterm birth (stillbirth and live birth), late miscarriage, maternal morbidity, and early onset neonatal sepsis...
December 7, 2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/25841891/safety-and-efficacy-of-alternative-antibiotic-regimens-compared-with-7-day-injectable-procaine-benzylpenicillin-and-gentamicin-for-outpatient-treatment-of-neonates-and-young-infants-with-clinical-signs-of-severe-infection-when-referral-is-not-possible-a-randomised
#7
RANDOMIZED CONTROLLED TRIAL
Abdullah H Baqui, Samir K Saha, A S M Nawshad Uddin Ahmed, Mohammad Shahidullah, Iftekhar Quasem, Daniel E Roth, A K M Samsuzzaman, Wazir Ahmed, S M Shahnawaz Bin Tabib, Dipak K Mitra, Nazma Begum, Maksuda Islam, Arif Mahmud, Mohammad Hefzur Rahman, Mamun Ibne Moin, Luke C Mullany, Simon Cousens, Shams El Arifeen, Stephen Wall, Neal Brandes, Mathuram Santosham, Robert E Black
BACKGROUND: Severe infections remain one of the main causes of neonatal deaths worldwide. Possible severe infection is diagnosed in young infants (aged 0-59 days) according to the presence of one or more clinical signs. The recommended treatment is hospital admission with 7-10 days of injectable antibiotic therapy. In low-income and middle-income countries, barriers to hospital care lead to delayed, inadequate, or no treatment for many young infants. We aimed to identify effective alternative antibiotic regimens to expand treatment options for situations where hospital admission is not possible...
May 2015: Lancet Global Health
https://www.readbyqxmd.com/read/23945570/safety-and-efficacy-of-simplified-antibiotic-regimens-for-outpatient-treatment-of-serious-infection-in-neonates-and-young-infants-0-59-days-of-age-in-bangladesh-design-of-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Abdullah H Baqui, Samir Kumar Saha, A S M Nawshad Uddin Ahmed, Mohammad Shahidullah, Iftekhar Quasem, Daniel E Roth, Emma K Williams, Dipak Mitra, A K M Shamsuzzaman, Wazir Ahmed, Luke C Mullany, Simon Cousens, Stephen Wall, Neal Brandes, Robert E Black
BACKGROUND: Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections. METHODS: We are conducting a trial to determine if simplified antibiotic regimens with fewer injections are as efficacious as the standard course of parenteral antibiotics for empiric treatment of young infants with clinical signs suggestive of severe infection in 4 urban hospitals and in a rural surveillance site in Bangladesh...
September 2013: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/20671849/is-ligation-of-hernial-sac-during-orchiopexy-mandatory
#9
Veena Kumari, Nilay Biswas, Nilanjan Mitra, Hiralal Konar, Dipak Ghosh, Sukanta K Das
AIM: Traditionally, ligation of hernial sac during orchiopexy is considered mandatory to prevent postoperative development of hernia. A prospective study was carried out to see if it is actually required based on the fact that any peritoneal defect closes within 24 hours by metamorphosis of the in situ mesodermal cells. METHODS: Fifty cases of undescended testis, age ranging from eight months to 12 years were enrolled. All of them underwent standard orchiopexy without ligation of the hernial sac...
April 2009: Journal of Indian Association of Pediatric Surgeons
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