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JOURNAL ARTICLE
Dan-Ying Lee, Ting-Yung Chang, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Ling Kuo, Chih-Min Liu, Shih-Ann Chen
AIMS: The efficacy of catheter ablation (CA) on clinical outcomes and cardiac structural remodelling in atrial fibrillation (AF) patients with HF with mildly reduced or mid-range ejection fraction (HFmrEF) remains unclear. We aimed to compare the efficacy of CA with medical therapy (MT) in AF patients with HFmrEF. METHODS AND RESULTS: We retrospectively screened a total of 36 879 patients with AF between 2005 and 2020. Patients who were initially diagnosed with echocardiography-proved HFmrEF and had follow-up echocardiography were enrolled...
September 30, 2022: ESC Heart Failure
#22
JOURNAL ARTICLE
Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès, Yutaka Kawakami, Jérôme Galon
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS)...
September 6, 2022: Cancers
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JOURNAL ARTICLE
Anne Cc Lee, Firehiwot Workneh Abate, Luke C Mullany, Estifanos Baye, Yoseph Yemane Berhane, Mulatu Melese Derebe, Michelle Eglovitch, Nebiyou Fasil, Ingrid E Olson, Workagegnehu Tarekegn Kidane, Tigest Shiferaw, Fisseha Shiferie, Fitsum Tsegaye, Sitota Tsegaye, Kalkidan Yibeltal, Grace J Chan, Parul Christian, Sheila Isanaka, Yunhee Kang, Chunling Lu, Mandefro M Mengistie, Rose L Molina, Michele D Stojanov, Fred Van Dyk, Amare Worku Tadesse, Asresie T Wondale, Blair J Wylie, Alemayehu Worku, Yemane Berhane
INTRODUCTION: The WHO Nutrition Target aims to reduce the global prevalence of low birth weight by 30% by the year 2025. The Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study will test the impact of packages of pregnancy interventions to enhance maternal nutrition and infection management on birth outcomes in rural Ethiopia. METHODS AND ANALYSIS: ENAT is a pragmatic, open-label, 2×2 factorial, randomised clinical effectiveness study implemented in 12 rural health centres in Amhara, Ethiopia...
January 2022: BMJ Paediatrics Open
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JOURNAL ARTICLE
Elke Ericson, Linnéa Bergenholm, Anne-Christine Andréasson, Carly I Dix, Jane Knöchel, Sara F Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt
In nonalcoholic fatty liver disease (NAFLD) the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization of triglycerides. To advance our understanding of the localization and abundance of PNPLA3 protein in humans, we used liver biopsies from patients with NAFLD to investigate the link to NAFLD and the PNPLA3 148M genotype...
July 14, 2022: Hepatology Communications
#25
JOURNAL ARTICLE
Katharina Nimptsch, Krasimira Aleksandrova, Veronika Fedirko, Mazda Jenab, Marc J Gunter, Peter D Siersema, Kana Wu, Verena Katzke, Rudolf Kaaks, Salvatore Panico, Domenico Palli, Anne M May, Sabina Sieri, Bas Bueno-de-Mesquita, Karina Standahl, Maria-Jose Sánchez, Aurora Perez-Cornago, Anja Olsen, Anne Tjønneland, Catalina Bonet Bonet, Christina C Dahm, María-Dolores Chirlaque, Valentina Fiano, Rosario Tumino, Aurelio Barricarte Gurrea, Marie-Christine Boutron-Ruault, Florence Menegaux, Gianluca Severi, Bethany van Guelpen, Young-Ae Lee, Tobias Pischon
BACKGROUND: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression...
June 24, 2022: BMC Cancer
#26
REVIEW
Emily Bryce, Sabi Gurung, Hannah Tong, Joanne Katz, Anne Cc Lee, Robert E Black, Neff Walker
Background: Complications associated with preterm birth (PTB) are the largest contributor to under-five mortality globally. Success in reaching the Sustainable Development Goal target requires identifying potentially modifiable risk factors for PTB, estimating the relative importance of these risk factors, and identifying/implementing effective prevention strategies to address them. Methods: We conducted a literature review to define risk relationships and estimate prevalence for established risk factors for spontaneous PTB (sPTB)...
2022: Journal of Global Health
#27
JOURNAL ARTICLE
Sabi Gurung, Hannah Hanzi Tong, Emily Bryce, Joanne Katz, Anne Cc Lee, Robert E Black, Neff Walker
Background: Small for gestational age (SGA) is a public health concern since it is associated with mortality in neonatal and post-neonatal period. Despite the large magnitude of the problem, little is known about the population-attributable risk (PAR) of various risk factors for SGA. This study estimated the relative contribution of risk factors for SGA, as a basis for identifying priority areas for developing and/or implementing interventions to reduce the incidence of SGA births and related mortality and morbidity...
2022: Journal of Global Health
#28
REVIEW
James C H Chow, Ka-Man Cheung, Gavin T C Cheung, Anthony H P Tam, Jeffrey C F Lui, Francis K H Lee, Kwok-Hung Au, Wai-Tong Ng, Anne W M Lee, Harry H Y Yiu
BACKGROUND AND PURPOSE: This systematic review aims to identify radiation dose-volume predictors of primary hypothyroidism after radiotherapy in patients with head and neck cancer (HNC). MATERIALS AND METHODS: We performed a systematic literature search of Medline, EMBASE and Web of Science from database inception to July 1, 2021 for articles that discuss radiation dose-volume predictors of post-radiation primary hypothyroidism in patients with HNC. Data on the incidence, clinical risk factors and radiation dose-volume parameters were extracted...
March 2022: Clinical and Translational Radiation Oncology
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JOURNAL ARTICLE
Alison S Clay, Erin R Leiman, Brent Jason Theiling, Yao Song, Blanca Blanca Iris Padilla, Nicholas M Hudak, Ann Michelle Hartman, Jeffrey M Hoder, Kathleen A Waite, Hui-Jie Lee, Edward G Buckley
BACKGROUND: Clinical education across the professions is challenged by a lack of recognition for faculty and pressure for patient throughput and revenue generation. These pressures may reduce direct observation of patient care provided by students, a requirement for both billing student-involved services and assessing competence. These same pressures may also limit opportunities for interprofessional education and collaboration. METHODS: An interprofessional group of faculty collaborated in a sequential quality improvement project to identify the best patients and physical location for a student teaching clinic...
January 27, 2022: BMC Medical Education
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JOURNAL ARTICLE
David Uihwan Lee, David Jeffrey Hastie, Ki Jung Lee, Gregory Hongyuan Fan, Elyse Ann Addonizio, Jean Kwon, Raffi Karagozian
BACKGROUND AND AIMS: Since there is clinical overlap between populations with cirrhosis and those who require hernia repair (i.e. due to stretching of abdominal walls), we systematically evaluate the effects of cirrhosis on post-hernia repair outcomes. METHODS: 2011-2017 National Inpatient Sample was used to identify patients who underwent hernia repair (included: inguinal, umbilical, and other abdominal hernia repairs). The population was stratified into those with compensated cirrhosis (CC), decompensated cirrhosis (DC), and no cirrhosis; hepatic decompensation was defined as those with portal hypertension, ascites, and varices...
December 1, 2021: European Journal of Gastroenterology & Hepatology
#31
REVIEW
Krysten North, Melanie Gao, Grace Allen, Anne Cc Lee
INTRODUCTION: More than 98% of infant deaths occur in low- and middle-income countries (LMICs). Breastfeeding improves infant survival and protects against certain illnesses, such as diarrhea and pneumonia, which are leading causes of deaths in those <5 years of age in LMICs. The World Health Organization (WHO) recommends early initiation of breastfeeding within 1 hour of birth, exclusive breastfeeding up to 6 months of age, and continued breastfeeding up to 2 years of age. However, fewer than half of infants in LMICs are breastfed optimally to these standards...
February 2022: Clinical Therapeutics
#32
JOURNAL ARTICLE
Linda Vesel, Lauren Spigel, Jnanindra Nath Behera, Roopa M Bellad, Leena Das, Sangappa Dhaded, Shivaprasad S Goudar, Gowdar Guruprasad, Sujata Misra, Sanghamitra Panda, Latha G Shamanur, Sunil S Vernekar, Irving F Hoffman, Tisungane Mvalo, Melda Phiri, Friday Saidi, Rodrick Kisenge, Karim Manji, Nahya Salim, Sarah Somji, Christopher R Sudfeld, Linda Adair, Bethany A Caruso, Christopher Duggan, Kiersten Israel-Ballard, Anne Cc Lee, Stephanie L Martin, Kimberly L Mansen, Krysten North, Melissa Young, Emily Benotti, Megan Marx Delaney, Eliza Fishman, Katelyn Fleming, Natalie Henrich, Kate Miller, Laura Subramanian, Danielle E Tuller, Katherine Ea Semrau
INTRODUCTION: Ending preventable deaths of newborns and children under 5 will not be possible without evidence-based strategies addressing the health and care of low birthweight (LBW, <2.5 kg) infants. The majority of LBW infants are born in low- and middle-income countries (LMICs) and account for more than 60%-80% of newborn deaths. Feeding promotion tailored to meet the nutritional needs of LBW infants in LMICs may serve a crucial role in curbing newborn mortality rates and promoting growth...
December 2, 2021: BMJ Open
#33
JOURNAL ARTICLE
Anne Cc Lee, Sara Cherkerzian, Ingrid E Olson, Salahuddin Ahmed, Nabidul Haque Chowdhury, Rasheda Khanam, Sayedur Rahman, Chloe Andrews, Abdullah H Baqui, Wafaie Fawzi, Terrie E Inder, Stephanie Nartey, Charles A Nelson, Emily Oken, Sarbattama Sen, Raina Fichorova
Inflammation may adversely affect early human brain development. We aimed to assess the role of maternal nutrition and infections on cord blood inflammation. In a pregnancy cohort in Sylhet, Bangladesh, we enrolled 251 consecutive pregnancies resulting in a term livebirth from July 2016-March 2017. Stillbirths, preterm births, and cases of neonatal encephalopathy were excluded. We prospectively collected data on maternal diet (food frequency questionnaire) and morbidity, and analyzed umbilical cord blood for interleukin (IL)-1α, IL-1β, IL-6, IL-8 and C-reactive protein...
October 26, 2021: Nutrients
#34
JOURNAL ARTICLE
Harriet L S Lawford, Mercy A Nuamah, Helen G Liley, Alison Griffin, Cecilia E Lekpor, Felix Botchway, Samuel A Oppong, Ali Samba, Ebenezer V Badoe, Sailesh Kumar, Anne Cc Lee, Richard K Gyasi, Andrew A Adjei, Samudragupta Bora
OBJECTIVE: To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy. METHODS: Pregnant women presenting at Korle Bu Teaching Hospital, Ghana were recruited into this prospective observational study. Malaria exposure was determined by clinically documented antenatal malaria infection; parasitemia in maternal, placental, or umbilical cord blood; or placental histology. Neurological functioning was assessed using the Hammersmith Neonatal Neurological Examination within 48 hours of birth...
November 2021: International Journal of Infectious Diseases: IJID
#35
REVIEW
Jackie Patterson, Krysten North, Eugene Dempsey, Daniel Ishoso, Daniele Trevisanuto, Anne Cc Lee, Beena D Kamath-Rayne
One million two hundred thousand neonatal lives are lost each year due to intrapartum-related events; 99% of these deaths occur in low- and lower middle-income countries. Neonates exposed to intrapartum-related events present with failure to breathe at birth. Quick and effective delivery room management of these neonates is critical in the prevention of brain injury. Given the prominent role of lung aeration in the cardiopulmonary transition at birth, the mainstay of neonatal resuscitation is effective ventilation...
August 2021: Seminars in Fetal & Neonatal Medicine
#36
JOURNAL ARTICLE
Ablative radiotherapy for liver tumors using stereotactic MRI-guidance: A prospective phase I trial.
Ritchell van Dams, Trudy C Wu, Amar U Kishan, Ann C Raldow, Fang-I Chu, Jackie Hernandez, Minsong Cao, James M Lamb, Argin Mikaeilian, Daniel A Low, Michael L Steinberg, Percy Lee
BACKGROUND AND PURPOSE: To prospectively determine the feasibility, safety, and efficacy of stereotactic body radiation therapy (SBRT) to primary and secondary liver tumors with MR-guided radiation therapy (MRgRT). MATERIALS AND METHODS: Treatment plans with a conventional CT-guided linear accelerator and a MRI-guided tri-60 Co teletherapy unit (MR-Co) were generated and compared for patients undergoing liver-directed SBRT from 2015 to 2017. If dosimetric parameters were met on MR-Co, patients were treated with MRgRT...
May 2022: Radiotherapy and Oncology
#37
JOURNAL ARTICLE
Phillip E Chow, Fang-I Chu, Nzhde Agazaryan, Minsong Cao, Margeurite Tyran, Yingli Yang, Daniel Low, Ann Raldow, Percy Lee, Michael Steinberg, James M Lamb
PURPOSE: Stereotactic magnetic resonance image-guided adaptive radiation therapy (SMART) is an emerging technique that shows promise in the treatment of pancreatic cancer and other abdominopelvic malignancies. However, it is unknown whether the time-limited nature of on-table adaptive planning may result in dosimetrically suboptimal plans. The purpose of this study was to quantitatively address that question through systemic retrospective replanning of treated on-table adaptive pancreatic cancer cases...
May 2021: Advances in Radiation Oncology
#38
JOURNAL ARTICLE
Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Ting-Yung Chang, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, Isaiah C Lugtu, Abigail Louise D Te, Ting-Chun Huang, Po-Tseng Lee, Jennifer Jeanne B Vicera, Shih-Ann Chen
AIMS: J-wave syndrome in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been linked to an increased risk of ventricular arrhythmia. We investigated the significance of J waves with respect to substrate manifestations and ablation outcomes in patients with ARVC. METHODS AND RESULTS: Forty-five patients with ARVC undergoing endocardial/epicardial mapping/ablation were studied. Patients were classified into two groups: 13 (28.9%) and 32 (71...
September 8, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#39
JOURNAL ARTICLE
Jagmeet Bhogal, Anne Lee Solevåg, Megan O'Reilly, Tze-Fun Lee, Chloe Joynt, Lisa K Hornberger, Georg M Schmölzer, Po-Yin Cheung
Respiratory failure is a common condition faced by critically ill neonates with respiratory distress syndrome (RDS). High frequency oscillatory ventilation (HFOV) is often used for neonates with refractory respiratory failure related to RDS. Volume guarantee (VG) mode has been added to some HFOV ventilators for providing consistent tidal volume. We sought to examine the impact of adding the VG mode during HFOV on systemic and cerebral hemodynamics, which has not been studied to date. A neonatal piglet model of moderate to severe RDS was induced by saline lavage...
2021: PloS One
#40
JOURNAL ARTICLE
Harriet L S Lawford, Mercy A Nuamah, Helen G Liley, Anne Cc Lee, Felix Botchway, Sailesh Kumar, Andrew A Adjei, Samudragupta Bora
OBJECTIVE: To describe gestational age-specific distribution of scores for the Hammersmith Neonatal Neurological Examination (HNNE) up to 48 h after birth in a low-risk, term-born, single-center sample in Ghana. STUDY DESIGN: This is a nested substudy of a larger prospective study (IMPRINT: Impact of Malaria in Pregnancy on Infant Neurodevelopment) comprising 140 low-risk, term-born neonates at Korle Bu Teaching Hospital in Accra, Ghana, between November 2018 and February 2019...
January 2021: Early Human Development
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