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https://www.readbyqxmd.com/read/27764907/assessment-of-the-asian-neurogastroenterology-and-motility-association-chronic-constipation-criteria-an-asian-multicenter-cross-sectional-study
#1
Kok-Ann Gwee, Paul Bergmans, JinYong Kim, Bogdana Coudsy, Angelia Sim, Minhu Chen, Lin Lin, Xiaohua Hou, Huahong Wang, Khean-Lee Goh, John A Pangilinan, Nayoung Kim, Stanislas Bruley des Varannes
Background/Aims: There is a need for a simple and practical tool adapted for the diagnosis of chronic constipation (CC) in the Asian population. This study compared the Asian Neurogastroenterology and Motility Association (ANMA) CC tool and Rome III criteria for the diagnosis of CC in Asian subjects. Methods: This multicenter, cross-sectional study included subjects presenting at outpatient gastrointestinal clinics across Asia. Subjects with CC alert symptoms completed a combination Diagnosis Questionnaire to obtain a diagnosis based on 4 different diagnostic methods: self-defined, investigator's judgment, ANMA CC tool, and Rome III criteria...
October 21, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27713600/association-of-single-nucleotide-polymorphisms-with-atrial-fibrillation-and-the-outcome-after-catheter-ablation
#2
Yu-Feng Hu, Hsueh-Hsiao Wang, Hung-I Yeh, Kun-Tai Lee, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Ta-Chuan Tuan, Cheng-Hung Li, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Paul Wei Hua Tang, Wei-Chung Tsai, Chuen-Wang Chiou, Shih-Ann Chen
BACKGROUND: The association of gene variants with atrial fibrillation (AF) type and the recurrence of AF after catheter ablation in Taiwan is still unclear. In this study, we aimed to investigate the relationships between gene variants, AF type, and the recurrence of AF. METHODS: In our investigation, we examined 383 consecutive patients with AF (61.9 ± 14.0 years; 63% men); of these 383 patients, 189 underwent catheter ablation for drug-refractory AF. Thereafter, the single nucleotide polymorphisms rs2200733, and rs7193343 were genotyped using real-time polymerase chain reaction...
September 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27703793/gadl1-variant-and-medication-adherence-in-predicting-response-to-lithium-maintenance-treatment-in-bipolar-i-disorder
#3
Chih-Ken Chen, Chau-Shoun Lee, Hsuan-Yu Chen, Lawrence Shih-Hsin Wu, Jung-Chen Chang, Chia-Yih Liu, Andrew Tai-Ann Cheng
BACKGROUND: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. AIMS: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. METHOD: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215)...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27529347/the-role-of-plasma-and-urine-metabolomics-in-identifying-new-biomarkers-in-severe-newborn-asphyxia-a-study-of-asphyxiated-newborn-pigs-following-cardiopulmonary-resuscitation
#4
Daniel Sachse, Anne Lee Solevåg, Jens Petter Berg, Britt Nakstad
BACKGROUND: Optimizing resuscitation is important to prevent morbidity and mortality from perinatal asphyxia. The metabolism of cells and tissues is severely disturbed during asphyxia and resuscitation, and metabolomic analyses provide a snapshot of many small molecular weight metabolites in body fluids or tissues. In this study metabolomics profiles were studied in newborn pigs that were asphyxiated and resuscitated using different protocols to identify biomarkers for subject characterization, intervention effects and possibly prognosis...
2016: PloS One
https://www.readbyqxmd.com/read/27524456/global-burden-epidemiologic-trends-and-prevention-of-intrapartum-related-deaths-in-low-resource-settings
#5
REVIEW
Shabina Ariff, Anne Cc Lee, Joy Lawn, Zulfiqar A Bhutta
Intrapartum-related neonatal deaths include live-born infants who die in the first 28 days of life from neonatal encephalopathy or die before onset of neonatal encephalopathy and have evidence of intrapartum injury. A smaller portion of the population in poorer countries has access to basic obstetric and postnatal care causing neonatal mortality rates to be higher. Presence of a skilled birth attendant and provision of basic emergency obstetric care can reduce intrapartum birth asphyxia by 40%. With the announcement of Sustainable Development Goals and global Every Newborn Action Plan, there is hope that interventions around continuum of care will save lives...
September 2016: Clinics in Perinatology
https://www.readbyqxmd.com/read/27344929/myocardial-perfusion-and-oxidative-stress-after-21-vs-100-oxygen-ventilation-and-uninterrupted-chest-compressions-in-severely-asphyxiated-piglets
#6
Anne Lee Solevåg, Georg M Schmölzer, Megan O'Reilly, Min Lu, Tze-Fun Lee, Lisa K Hornberger, Britt Nakstad, Po-Yin Cheung
AIM: Despite the minimal evidence, neonatal resuscitation guidelines recommend using 100% oxygen when chest compressions (CC) are needed. Uninterrupted CC in adult cardiopulmonary resuscitation (CPR) may improve CPR hemodynamics. We aimed to examine 21% oxygen (air) vs. 100% oxygen in 3:1 CC:ventilation (C:V) CPR or continuous CC with asynchronous ventilation (CCaV) in asphyxiated newborn piglets following cardiac arrest. METHODS: Piglets (1-3 days old) were progressively asphyxiated until cardiac arrest and randomized to 4 experimental groups (n=8 each): air and 3:1 C:V CPR, 100% oxygen and 3:1 C:V CPR, air and CCaV, or 100% oxygen and CCaV...
September 2016: Resuscitation
https://www.readbyqxmd.com/read/27313070/validity-of-newborn-clinical-assessment-to-determine-gestational-age-in-bangladesh
#7
Anne Cc Lee, Luke C Mullany, Karima Ladhani, Jamal Uddin, Dipak Mitra, Parvez Ahmed, Parul Christian, Alain Labrique, Sushil K DasGupta, R Peter Lokken, Mohammed Quaiyum, Abdullah H Baqui
BACKGROUND: Gestational age (GA) is frequently unknown or inaccurate in pregnancies in low-income countries. Early identification of preterm infants may help link them to potentially life-saving interventions. METHODS: We conducted a validation study in a community-based birth cohort in rural Bangladesh. GA was determined by pregnancy ultrasound (<20 weeks). Community health workers conducted home visits (<72 hours) to assess physical/neuromuscular signs and measure anthropometrics...
July 2016: Pediatrics
https://www.readbyqxmd.com/read/26936864/telemedicine-for-ophthalmic-consultation-services-use-of-a-portable-device-and-layering-information-for-graders
#8
Maria A Woodward, J Clay Bavinger, Sejal Amin, Taylor S Blachley, David C Musch, Paul P Lee, Paula Anne Newman-Casey
INTRODUCTION: We compared remote, image-based patient consultations to in-person consultations at emergency department and inpatient hospital settings. METHODS: Patients evaluated by the ophthalmic consultation services (gold standard) were imaged over a two-week period. A trained study coordinator took anterior segment photographs (AS) and posterior segment photographs (PS) with a portable camera (PictorPlus, Volk Optical, Cleveland, OH). Ophthalmologists (graders) determined photograph quality, presence of pathology, and their confidence in disease detection...
March 1, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/26854475/impact-of-egf-il28b-and-pnpla3-polymorphisms-on-the-outcome-of-allograft-hepatitis-c-a-multicenter-study
#9
Jessica L Mueller, Lindsay Y King, Kara B Johnson, Tian Gao, Lauren D Nephew, Darshan Kothari, Mary Ann Simpson, Hui Zheng, Lan Wei, Kathleen E Corey, Joseph Misdraji, Joon Hyoek Lee, M Valerie Lin, Neliswa A Gogela, Bryan C Fuchs, Kenneth K Tanabe, Fredric D Gordon, Michael P Curry, Raymond T Chung
Hepatitis C virus (HCV) infection is accelerated following liver transplantation (LT). Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non-transplant hepatitis C, but allograft population data are limited. We sought to determine the role of these SNPs in 264 patients with HCV who underwent LT between 1990 and 2008. Genotypes were determined from donor wedge/allograft biopsies and recipient explants...
April 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26627554/a-review-of-approaches-to-optimise-chest-compressions-in-the-resuscitation-of-asphyxiated-newborns
#10
REVIEW
Anne Lee Solevåg, Po-Yin Cheung, Megan O'Reilly, Georg M Schmölzer
OBJECTIVE: Provision of chest compressions (CCs) and/or medications in the delivery room is associated with poor outcomes. Based on the physiology of perinatal asphyxia, we aimed to provide an overview of current recommendations and explore potential determinants of effective neonatal cardiopulmonary resuscitation (CPR): balancing ventilations and CC, CC rate, depth, full chest recoil, CC technique and adrenaline. DESIGN: A search in the databases MEDLINE (Ovid) and EMBASE until 10 April 2015...
May 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26566091/rescuers-physical-fatigue-with-different-chest-compression-to-ventilation-methods-during-simulated-infant-cardiopulmonary-resuscitation
#11
Anne Marthe Boldingh, Thomas Hagen Jensen, Ane Torvik Bjørbekk, Anne Lee Solevåg, Britt Nakstad
OBJECTIVE: To assess development of objective, subjective and indirect measures of fatigue during simulated infant cardiopulmonary resuscitation (CPR) with two different methods. METHODS: Using a neonatal manikin, 17 subject-pairs were randomized in a crossover design to provide 5-min CPR with a 3:1 chest compression (CC) to ventilation (C:V) ratio and continuous CCs at a rate of 120 min(-1) with asynchronous ventilations (CCaV-120). We measured participants' changes in heart rate (HR) and mean arterial pressure (MAP); perceived level of fatigue on a validated Likert scale; and manikin CC measures...
October 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26296585/chest-compressions-in-newborn-animal-models-a-review
#12
REVIEW
Anne Lee Solevåg, Po-Yin Cheung, Helene Lie, Megan O'Reilly, Khalid Aziz, Britt Nakstad, Georg Marcus Schmölzer
OBJECTIVE: Much of the knowledge about the optimal way to perform chest compressions (CC) in newborn infants is derived from animal studies. The objective of this review was to identify studies of CC in newborn term animal models and review the evidence. We also provide an overview of the different models. METHODS: HASH(0x2d34f90) DATA SOURCES: MEDLINE, EMBASE and CINAHL, until September 29th 2014. Study eligibility criteria and interventions: term newborn animal models where CC was performed...
November 2015: Resuscitation
https://www.readbyqxmd.com/read/26248671/pre-operative-embolization-of-a-choroid-plexus-carcinoma-review-of-the-vascular-anatomy
#13
Lee-Anne Slater, Caitlin Hoffman, James Drake, Timo Krings
AIM: The purpose of this case is to highlight the benefits of preoperative embolization as well as to review the vascular anatomy that needs to be recognized in order to perform pre-operative embolization of choroid plexus tumors. METHOD: We achieve this by presenting the case of a 12-month-old female who had symptoms of raised intracranial pressure. MRI demonstrated a large vividly enhancing mass centered within the atria of the right lateral ventricle associated with hydrocephalus in keeping with a choroid plexus tumor...
March 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/26135764/quantifying-force-application-to-a-newborn-manikin-during-simulated-cardiopulmonary-resuscitation
#14
Anne Lee Solevåg, Po-Yin Cheung, Elliott Li, Khalid Aziz, Megan O'Reilly, Bo Fu, Bin Zheng, Georg Schmölzer
OBJECTIVE: To assess utility of the FingerTPS™ system in measuring chest compression (CC) rate and force. METHODS: Five minutes of CC was performed in a neonatal manikin without (n = 29) and with (n = 30) a metronome. The FingerTPS™ force (lbs.) was compared to pressure (mmHg) in a 50-mL normal-saline bag inside the manikin. FingerTPS™ CC rate and the time until a 20% decline from baseline force and pressure were calculated. RESULTS: The normal-saline pressure declined earlier than the FingerTPS™ force...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/24274619/conformers-of-cysteine-and-cysteine-sulfenic-acid-and-mechanisms-of-the-reaction-of-cysteine-sulfenic-acid-with-5-5-dimethyl-1-3-cyclohexanedione-dimedone
#15
Fillmore Freeman, Ifeoluwa Taiwo Adesina, Julie Le La, Joseph Yonghun Lee, Amelia Ann Poplawski
Equilibrium and molecular structures, relative energies of conformers of gaseous cysteine (Cys, C, Cys-SH) and gaseous cysteine sulfenic acid (Cys-SOH), and the mechanisms of the reaction of Cys-SOH with 3-hydroxy-5,5-dimethyl-2-cyclohexen-1-one, the enol tautomer of 5,5-dimethyl-1,3-cyclohexadione (dimedone), have been studied using BD(T), CCSD(T), and QCISD(T) with the cc-pVTZ basis set and using MP2 and the density functionals B3LYP, B3PW91, PBE1PBE, PBEh1PBE, M062X, CAM-B3LYP, and WB97XD with the 6-311+G(d,p) basis set...
December 19, 2013: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/23727379/variability-of-breast-density-assessment-in-short-term-reimaging-with-digital-mammography
#16
Won Hwa Kim, Woo Kyung Moon, Sun Mi Kim, Ann Yi, Jung Min Chang, Hye Ryoung Koo, Su Hyun Lee, Nariya Cho
OBJECTIVE: To evaluate the variability of breast density assessments in short-term reimaging with digital mammography. MATERIALS AND METHODS: In 186 women, short term (mean interval, 27.6 days) serial digital mammograms including CC and MLO views were obtained without any treatment. Mammographic density assessments were performed by three blinded radiologists for Breast Imaging Report and Data System (BI-RADS, grades 1-4) and visual percentage density (PD) estimation, and by one radiologist for computer-aided PD estimation...
October 2013: European Journal of Radiology
https://www.readbyqxmd.com/read/23341447/%C3%AE-arrestin-recruitment-and-g-protein-signaling-by-the-atypical-human-chemokine-decoy-receptor-ccx-ckr
#17
Anne O Watts, Folkert Verkaar, Miranda M C van der Lee, Claudia A W Timmerman, Martien Kuijer, Jody van Offenbeek, Lambertus H C J van Lith, Martine J Smit, Rob Leurs, Guido J R Zaman, Henry F Vischer
Chemokine receptors form a large subfamily of G protein-coupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune cell migration. CCX-CKR is an atypical chemokine receptor with high affinity for CCL19, CCL21, and CCL25 chemokines, but is not known to activate intracellular signaling pathways. However, CCX-CKR acts as decoy receptor and efficiently internalizes these chemokines, thereby preventing their interaction with other chemokine receptors, like CCR7 and CCR9. Internalization of fluorescently labeled CCL19 correlated with β-arrestin2-GFP translocation...
March 8, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/22984439/%C3%AE-catenin-is-genetically-and-biologically-associated-with-cortical-cataract-and-future-alzheimer-related-structural-and-functional-brain-changes
#18
Gyungah Jun, Juliet A Moncaster, Carolina Koutras, Sudha Seshadri, Jacqueline Buros, Ann C McKee, Georges Levesque, Philip A Wolf, Peter St George-Hyslop, Lee E Goldstein, Lindsay A Farrer
Multiple lines of evidence suggest that specific subtypes of age-related cataract (ARC) and Alzheimer disease (AD) are related etiologically. To identify shared genetic factors for ARC and AD, we estimated co-heritability of quantitative measures of cataract subtypes with AD-related brain MRI traits among 1,249 members of the Framingham Eye Study who had a brain MRI scan approximately ten years after the eye exam. Cortical cataract (CC) was found to be co-heritable with future development of AD and with several MRI traits, especially temporal horn volume (THV, ρ = 0...
2012: PloS One
https://www.readbyqxmd.com/read/22867710/elevated-expression-of-the-chemokine-scavenging-receptor-d6-is-associated-with-impaired-lesion-development-in-psoriasis
#19
Mark D Singh, Vicky King, Helen Baldwin, David Burden, Anne Thorrat, Susan Holmes, Iain B McInnes, Ruairidh Nicoll, Kave Shams, Kenneth Pallas, Thomas Jamieson, Kit Ming Lee, Jose M Carballido, Antal Rot, Gerard J Graham
D6 is a scavenging-receptor for inflammatory CC chemokines that are essential for resolution of inflammatory responses in mice. Here, we demonstrate that D6 plays a central role in controlling cutaneous inflammation, and that D6 deficiency is associated with development of a psoriasis-like pathology in response to varied inflammatory stimuli in mice. Examination of D6 expression in human psoriatic skin revealed markedly elevated expression in both the epidermis and lymphatic endothelium in "uninvolved" psoriatic skin (ie, skin that was more than 8 cm distant from psoriatic plaques)...
October 2012: American Journal of Pathology
https://www.readbyqxmd.com/read/22397344/maternal-perceptions-of-help-from-home-visits-by-nurse-community-health-worker-teams
#20
RANDOMIZED CONTROLLED TRIAL
Lee Anne Roman, Jennifer E Raffo, Cristian I Meghea
We used data from a home visiting trial to examine low-income women's perceptions of services received from nurses (the community care [CC] group) and from a nurse-community health worker (CHW) team. More mothers in the nurse-CHW group than in the CC group reported receiving help in all of the categories assessed. For both groups, assistance with health education ranked highest among the types of assistance received. A higher percentage of women in the nurse-CHW group than the CC group reported that they received psychosocial help...
April 2012: American Journal of Public Health
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