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https://www.readbyqxmd.com/read/30018877/considerations-and-consequences-of-allowing-dna-sequence-data-as-types-of-fungal-taxa
#1
Juan Carlos Zamora, Måns Svensson, Roland Kirschner, Ibai Olariaga, Svengunnar Ryman, Luis Alberto Parra, József Geml, Anna Rosling, Slavomír Adamčík, Teuvo Ahti, M Catherine Aime, A Martyn Ainsworth, László Albert, Edgardo Albertó, Alberto Altés García, Dmitry Ageev, Reinhard Agerer, Begoña Aguirre-Hudson, Joe Ammirati, Harry Andersson, Claudio Angelini, Vladimír Antonín, Takayuki Aoki, André Aptroot, Didier Argaud, Blanca Imelda Arguello Sosa, Arne Aronsen, Ulf Arup, Bita Asgari, Boris Assyov, Violeta Atienza, Ditte Bandini, João Luís Baptista-Ferreira, Hans-Otto Baral, Tim Baroni, Robert Weingart Barreto, Henry Beker, Ann Bell, Jean-Michel Bellanger, Francesco Bellù, Martin Bemmann, Mika Bendiksby, Egil Bendiksen, Katriina Bendiksen, Lajos Benedek, Anna Bérešová-Guttová, Franz Berger, Reinhard Berndt, Annarosa Bernicchia, Alona Yu Biketova, Enrico Bizio, Curtis Bjork, Teun Boekhout, David Boertmann, Tanja Böhning, Florent Boittin, Carlos G Boluda, Menno W Boomsluiter, Jan Borovička, Tor Erik Brandrud, Uwe Braun, Irwin Brodo, Tatiana Bulyonkova, Harold H Burdsall, Bart Buyck, Ana Rosa Burgaz, Vicent Calatayud, Philippe Callac, Emanuele Campo, Massimo Candusso, Brigitte Capoen, Joaquim Carbó, Matteo Carbone, Rafael F Castañeda-Ruiz, Michael A Castellano, Jie Chen, Philippe Clerc, Giovanni Consiglio, Gilles Corriol, Régis Courtecuisse, Ana Crespo, Cathy Cripps, Pedro W Crous, Gladstone Alves da Silva, Meiriele da Silva, Marjo Dam, Nico Dam, Frank Dämmrich, Kanad Das, Linda Davies, Eske De Crop, Andre De Kesel, Ruben De Lange, Bárbara De Madrignac Bonzi, Thomas Edison E Dela Cruz, Lynn Delgat, Vincent Demoulin, Dennis E Desjardin, Paul Diederich, Bálint Dima, Maria Martha Dios, Pradeep Kumar Divakar, Clovis Douanla-Meli, Brian Douglas, Elisandro Ricardo Drechsler-Santos, Paul S Dyer, Ursula Eberhardt, Damien Ertz, Fernando Esteve-Raventós, Javier Angel Etayo Salazar, Vera Evenson, Guillaume Eyssartier, Edit Farkas, Alain Favre, Anna G Fedosova, Mario Filippa, Péter Finy, Adam Flakus, Simón Fos, Jacques Fournier, André Fraiture, Paolo Franchi, Ana Esperanza Franco Molano, Gernot Friebes, Andreas Frisch, Alan Fryday, Giuliana Furci, Ricardo Galán Márquez, Matteo Garbelotto, Joaquina María García-Martín, Mónica A García Otálora, Dania García Sánchez, Alain Gardiennet, Sigisfredo Garnica, Isaac Garrido Benavent, Genevieve Gates, Alice da Cruz Lima Gerlach, Masoomeh Ghobad-Nejhad, Tatiana B Gibertoni, Tine Grebenc, Irmgard Greilhuber, Bella Grishkan, Johannes Z Groenewald, Martin Grube, Gérald Gruhn, Cécile Gueidan, Gro Gulden, Luis Fp Gusmão, Josef Hafellner, Michel Hairaud, Marek Halama, Nils Hallenberg, Roy E Halling, Karen Hansen, Christoffer Bugge Harder, Jacob Heilmann-Clausen, Stip Helleman, Alain Henriot, Margarita Hernandez-Restrepo, Raphaël Herve, Caroline Hobart, Mascha Hoffmeister, Klaus Høiland, Jan Holec, Håkon Holien, Karen Hughes, Vit Hubka, Seppo Huhtinen, Boris Ivančević, Marian Jagers, Walter Jaklitsch, AnnaElise Jansen, Ruvishika S Jayawardena, Thomas Stjernegaard Jeppesen, Mikael Jeppson, Peter Johnston, Per Magnus Jørgensen, Ingvar Kärnefelt, Liudmila B Kalinina, Gintaras Kantvilas, Mitko Karadelev, Taiga Kasuya, Ivona Kautmanová, Richard W Kerrigan, Martin Kirchmair, Anna Kiyashko, Dániel G Knapp, Henning Knudsen, Kerry Knudsen, Tommy Knutsson, Miroslav Kolařík, Urmas Kõljalg, Alica Košuthová, Attila Koszka, Heikki Kotiranta, Vera Kotkova, Ondřej Koukol, Jiří Kout, Gábor M Kovács, Martin Kříž, Åsa Kruys, Viktor Kučera, Linas Kudzma, Francisco Kuhar, Martin Kukwa, T K Arun Kumar, Vladimír Kunca, Ivana Kušan, Thomas W Kuyper, Carlos Lado, Thomas Læssøe, Patrice Lainé, Ewald Langer, Ellen Larsson, Karl-Henrik Larsson, Gary Laursen, Christian Lechat, Serena Lee, James C Lendemer, Laura Levin, Uwe Lindemann, Håkan Lindström, Xingzhong Liu, Regulo Carlos Llarena Hernandez, Esteve Llop, Csaba Locsmándi, Deborah Jean Lodge, Michael Loizides, László Lőkös, Jennifer Luangsa-Ard, Matthias Lüderitz, Thorsten Lumbsch, Matthias Lutz, Dan Mahoney, Ekaterina Malysheva, Vera Malysheva, Patinjareveettil Manimohan, Yasmina Marin-Felix, Guilhermina Marques, Rubén Martínez-Gil, Guy Marson, Gerardo Mata, P Brandon Matheny, Geir Harald Mathiassen, Neven Matočec, Helmut Mayrhofer, Mehdi Mehrabi, Ireneia Melo, Armin Mešić, Andrew S Methven, Otto Miettinen, Ana M Millanes Romero, Andrew N Miller, James K Mitchell, Roland Moberg, Pierre-Arthur Moreau, Gabriel Moreno, Olga Morozova, Asunción Morte, Lucia Muggia, Guillermo Muñoz González, Leena Myllys, István Nagy, László G Nagy, Maria Alice Neves, Tuomo Niemelä, Pier Luigi Nimis, Nicolas Niveiro, Machiel E Noordeloos, Anders Nordin, Sara Raouia Noumeur, Yuri Novozhilov, Jorinde Nuytinck, Esteri Ohenoja, Patricia Oliveira Fiuza, Alan Orange, Alexander Ordynets, Beatriz Ortiz-Santana, Leticia Pacheco, Ferenc Pál-Fám, Melissa Palacio, Zdeněk Palice, Viktor Papp, Kadri Pärtel, Julia Pawlowska, Aurelia Paz, Ursula Peintner, Shaun Pennycook, Olinto Liparini Pereira, Pablo Pérez Daniëls, Miquel À Pérez-De-Gregorio Capella, Carlos Manuel Pérez Del Amo, Sergio Pérez Gorjón, Sergio Pérez-Ortega, Israel Pérez-Vargas, Brian A Perry, Jens H Petersen, Ronald H Petersen, Donald H Pfister, Chayanard Phukhamsakda, Marcin Piątek, Meike Piepenbring, Raquel Pino-Bodas, Juan Pablo Pinzón Esquivel, Paul Pirot, Eugene S Popov, Orlando Popoff, María Prieto Álvaro, Christian Printzen, Nadezhda Psurtseva, Witoon Purahong, Luis Quijada, Gerhard Rambold, Natalia A Ramírez, Huzefa Raja, Olivier Raspé, Tania Raymundo, Martina Réblová, Yury A Rebriev, Juan de Dios Reyes García, Miguel Ángel Ribes Ripoll, Franck Richard, Mike J Richardson, Víctor J Rico, Gerardo Lucio Robledo, Flavia Rodrigues Barbosa, Cristina Rodriguez-Caycedo, Pamela Rodriguez-Flakus, Anna Ronikier, Luis Rubio Casas, Katerina Rusevska, Günter Saar, Irja Saar, Isabel Salcedo, Sergio M Salcedo Martínez, Carlos A Salvador Montoya, Santiago Sánchez-Ramírez, J Vladimir Sandoval-Sierra, Sergi Santamaria, Josiane Santana Monteiro, Hans Josef Schroers, Barbara Schulz, Geert Schmidt-Stohn, Trond Schumacher, Beatrice Senn-Irlet, Hana Ševčíková, Oleg Shchepin, Takashi Shirouzu, Anton Shiryaev, Klaus Siepe, Esteban B Sir, Mohammad Sohrabi, Karl Soop, Viacheslav Spirin, Toby Spribille, Marc Stadler, Joost Stalpers, Soili Stenroos, Ave Suija, Stellan Sunhede, Sten Svantesson, Sigvard Svensson, Tatyana Yu Svetasheva, Krzysztof Świerkosz, Heidi Tamm, Hatira Taskin, Adrien Taudière, Jan-Olof Tedebrand, Raúl Tena Lahoz, Marina Temina, Arne Thell, Marco Thines, Göran Thor, Holger Thüs, Leif Tibell, Sanja Tibell, Einar Timdal, Zdenko Tkalčec, Tor Tønsberg, Gérard Trichies, Dagmar Triebel, Andrei Tsurykau, Rodham E Tulloss, Veera Tuovinen, Miguel Ulloa Sosa, Carlos Urcelay, François Valade, Ricardo Valenzuela Garza, Pieter van den Boom, Nicolas Van Vooren, Aida M Vasco-Palacios, Jukka Vauras, Juan Manuel Velasco Santos, Else Vellinga, Annemieke Verbeken, Per Vetlesen, Alfredo Vizzini, Hermann Voglmayr, Sergey Volobuev, Wolfgang von Brackel, Elena Voronina, Grit Walther, Roy Watling, Evi Weber, Mats Wedin, Øyvind Weholt, Martin Westberg, Eugene Yurchenko, Petr Zehnálek, Huang Zhang, Mikhail P Zhurbenko, Stefan Ekman
Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018)...
June 2018: IMA Fungus
https://www.readbyqxmd.com/read/30016242/distinguishing-zika-and-dengue-viruses-through-simple-clinical-assessment-singapore
#2
Gabriel Yan, Long Pang, Alex R Cook, Hanley J Ho, Mar Soe Win, Ai Leng Khoo, Joshua G X Wong, Chun Kiat Lee, Benedict Yan, Roland Jureen, Siew Seen Ho, David C Lye, Paul A Tambyah, Yee Sin Leo, Dale Fisher, Jolene Oon, Natasha Bagdasarian, Angela Chow, Nares Smitasin, Louis Yi Ann Chai
Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case-control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/30014706/a-systematic-review-of-race-ethnicity-and-parental-treatment-decision-making
#3
Vandra C Harris, Anne R Links, Jonathan Walsh, Desi P Schoo, Andrew H Lee, David E Tunkel, Emily F Boss
Patient race/ethnicity affects health care utilization, provider trust, and treatment choice. It is uncertain how these influences affect pediatric care. We performed a systematic review (PubMed, Scopus, Web of Science, PsycINFO, Cochrane, and Embase) for articles examining race/ethnicity and parental treatment decision-making, adhering to PRISMA methodology. A total of 9200 studies were identified, and 17 met inclusion criteria. Studies focused on treatment decisions concerning end-of-life care, human papillomavirus vaccination, urological surgery, medication regimens, and dental care...
July 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/30012841/plc-and-ip-3-evoked-ca-2-release-initiate-the-fast-block-to-polyspermy-in-xenopus-laevis-eggs
#4
Katherine L Wozniak, Maiwase Tembo, Wesley A Phelps, Miler T Lee, Anne E Carlson
The prevention of polyspermy is essential for the successful progression of normal embryonic development in most sexually reproducing species. In external fertilizers, the process of fertilization induces a depolarization of the egg's membrane within seconds, which inhibits supernumerary sperm from entering an already-fertilized egg. This fast block requires an increase of intracellular Ca2+ in the African clawed frog, Xenopus laevis , which in turn activates an efflux of Cl- that depolarizes the cell. Here we seek to identify the source of this intracellular Ca2+ Using electrophysiology, pharmacology, bioinformatics, and developmental biology, we explore the requirement for both Ca2+ entry into the egg from the extracellular milieu and Ca2+ release from an internal store, to mediate fertilization-induced depolarization...
July 16, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/30012548/the-development-of-complex-digital-health-solutions-formative-evaluation-combining-different-methodologies
#5
Anne Lee, Marianne Sandvei, Hans Christian Asmussen, Marie Skougaard, Joanne Macdonald, Jakub Zavada, Henning Bliddal, Peter C Taylor, Henrik Gudbergsen
BACKGROUND: The development of digital health solutions for current health care settings requires an understanding of the complexities of the health care system, organizational setting, and stakeholder groups and of the underlying interplay between stakeholders and the technology. The digital health solution was founded on the basis of an information and communication technology platform and point-of-care devices enabling home-based monitoring of disease progression and treatment outcome for patients with rheumatoid arthritis (RA)...
July 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30005900/espen-guideline-on-clinical-nutrition-and-hydration-in-geriatrics
#6
Dorothee Volkert, Anne Marie Beck, Tommy Cederholm, Alfonso Cruz-Jentoft, Sabine Goisser, Lee Hooper, Eva Kiesswetter, Marcello Maggio, Agathe Raynaud-Simon, Cornel C Sieber, Lubos Sobotka, Dieneke van Asselt, Rainer Wirth, Stephan C Bischoff
BACKGROUND: Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats. AIM: To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration. Further, to address whether weight-reducing interventions are appropriate for overweight or obese older persons...
June 18, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29989858/analysis-of-plasma-epstein-barr-virus-dna-in-nasopharyngeal-cancer-after-chemoradiation-to-identify-high-risk-patients-for-adjuvant-chemotherapy-a-randomized-controlled-trial
#7
Anthony T C Chan, Edwin P Hui, Roger K C Ngan, Stewart Y Tung, Ashley C K Cheng, Wai T Ng, Victor H F Lee, Brigette B Y Ma, Hoi C Cheng, Frank C S Wong, Herbert H F Loong, Macy Tong, Darren M C Poon, Anil T Ahuja, Ann D King, Ki Wang, Frankie Mo, Benny C Y Zee, K C Allen Chan, Y M Dennis Lo
Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker of subclinical residual disease in NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV DNA to identify patients with NPC at a higher risk of relapse for adjuvant chemotherapy. Patients and Methods Eligible patients with histologically confirmed NPC of Union for International Cancer Control stage IIB to IVB, adequate organ function, and no locoregional disease or distant metastasis were screened by plasma EBV DNA at 6 to 8 weeks after radiotherapy (RT)...
July 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29985866/0-01-hypochlorous-acid-as-an-alternative-skin-antiseptic-an-in-vitro-comparison
#8
Apostolos G Anagnostopoulos, Andrew Rong, Darlene Miller, Ann Q Tran, Trajen Head, Michael C Lee, Wendy W Lee
OBJECTIVE: Compare the in vitro efficacy of hypochlorous acid 0.01% (HA), povidone iodine 5% (PI), chlorhexidine gluconate 4% (CHG), and isopropyl alcohol 70% (IPA) against common skin microorganisms. MATERIALS AND METHODS: Time-kill studies were conducted against methicillin-susceptible Staphylococcus aureus (MSSA) and Staphylococcus epidermidis (MSSE), methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE), Candida albicans, Corynebacterium species (striatum and amycolatum), Propionibacterium acnes, Pseudomonas aeruginosa, Streptococcus pyogenes, Staphylococcus capitis, and Staphylococcus xylosus...
July 6, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29979793/variants-in-genes-encoding-small-gtpases-and-association-with-epithelial-ovarian-cancer-susceptibility
#9
Madalene Earp, Jonathan P Tyrer, Stacey J Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja K H Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Clareann H Bunker, Ralf Butzow, Ian G Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Evelyn Despierre, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Douglas F Easton, Diana M Eccles, Robert P Edwards, Arif B Ekici, Peter A Fasching, Brooke L Fridley, Aleksandra Gentry-Maharaj, Graham G Giles, Rosalind Glasspool, Marc T Goodman, Jacek Gronwald, Philipp Harter, Alexander Hein, Florian Heitz, Michelle A T Hildebrandt, Peter Hillemanns, Claus K Hogdall, Estrid Høgdall, Satoyo Hosono, Edwin S Iversen, Anna Jakubowska, Allan Jensen, Bu-Tian Ji, Audrey Y Jung, Beth Y Karlan, Melissa Kellar, Lambertus A Kiemeney, Boon Kiong Lim, Susanne K Kjaer, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D Le, Shashi Lele, Jenny Lester, Douglas A Levine, Zheng Li, Dong Liang, Jolanta Lissowska, Karen Lu, Jan Lubinski, Lene Lundvall, Leon F A G Massuger, Keitaro Matsuo, Valerie McGuire, John R McLaughlin, Iain McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Heli Nevanlinna, Kunle Odunsi, Sara H Olson, Irene Orlow, Sandra Orsulic, James Paul, Tanja Pejovic, Liisa M Pelttari, Jenny B Permuth, Malcolm C Pike, Elizabeth M Poole, Barry Rosen, Mary Anne Rossing, Joseph H Rothstein, Ingo B Runnebaum, Iwona K Rzepecka, Eva Schernhammer, Ira Schwaab, Xiao-Ou Shu, Yurii B Shvetsov, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa C Southey, Beata Spiewankiewicz, Lara Sucheston-Campbell, Ingvild L Tangen, Soo-Hwang Teo, Kathryn L Terry, Pamela J Thompson, Lotte Thomsen, Shelley S Tworoger, Anne M van Altena, Ignace Vergote, Liv Cecilie Vestrheim Thomsen, Robert A Vierkant, Christine S Walsh, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S Whittemore, Kristine G Wicklund, Lynne R Wilkens, Yin-Ling Woo, Anna H Wu, Xifeng Wu, Yong-Bing Xiang, Hannah Yang, Wei Zheng, Argyrios Ziogas, Alice W Lee, Celeste L Pearce, Andrew Berchuck, Joellen M Schildkraut, Susan J Ramus, Alvaro N A Monteiro, Steven A Narod, Thomas A Sellers, Simon A Gayther, Linda E Kelemen, Georgia Chenevix-Trench, Harvey A Risch, Paul D P Pharoah, Ellen L Goode, Catherine M Phelan
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport. We hypothesized that common germline variation in genes encoding small GTPases is associated with EOC risk. We investigated 322 variants in 88 small GTPase genes in germline DNA of 18,736 EOC patients and 26,138 controls of European ancestry using a custom genotype array and logistic regression fitting log-additive models...
2018: PloS One
https://www.readbyqxmd.com/read/29971151/mental-health-in-uk-biobank-development-implementation-and-results-from-an-online-questionnaire-completed-by-157-366-participants
#10
Katrina A S Davis, Jonathan R I Coleman, Mark Adams, Naomi Allen, Gerome Breen, Breda Cullen, Chris Dickens, Elaine Fox, Nick Graham, Jo Holliday, Louise M Howard, Ann John, William Lee, Rose McCabe, Andrew McIntosh, Robert Pearsall, Daniel J Smith, Cathie Sudlow, Joey Ward, Stan Zammit, Matthew Hotopf
Background: UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims: An online mental health questionnaire completed by UK Biobank participants was expected to expand the potential for research into mental disorders. Method: An expert working group designed the questionnaire, using established measures where possible, and consulting with a patient group regarding acceptability...
May 2018: BJPsych Open
https://www.readbyqxmd.com/read/29969450/cellprofiler-3-0-next-generation-image-processing-for-biology
#11
Claire McQuin, Allen Goodman, Vasiliy Chernyshev, Lee Kamentsky, Beth A Cimini, Kyle W Karhohs, Minh Doan, Liya Ding, Susanne M Rafelski, Derek Thirstrup, Winfried Wiegraebe, Shantanu Singh, Tim Becker, Juan C Caicedo, Anne E Carpenter
CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common in biomedical research. CellProfiler's infrastructure is greatly improved, and we provide a protocol for cloud-based, large-scale image processing. New plugins enable running pretrained deep learning models on images...
July 2018: PLoS Biology
https://www.readbyqxmd.com/read/29967939/sex-specific-genetic-predictors-of-alzheimer-s-disease-biomarkers
#12
Yuetiva Deming, Logan Dumitrescu, Lisa L Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A Gifford, William S Bush, Lori B Chibnik, Shubhabrata Mukherjee, Philip L De Jager, Walter Kukull, Matt Huentelman, Paul K Crane, Susan M Resnick, C Dirk Keene, Thomas J Montine, Gerard D Schellenberg, Jonathan L Haines, Henrik Zetterberg, Kaj Blennow, Eric B Larson, Sterling C Johnson, Marilyn Albert, Abhay Moghekar, Jorge L Del Aguila, Maria Victoria Fernandez, John Budde, Jason Hassenstab, Anne M Fagan, Matthias Riemenschneider, Ronald C Petersen, Lennart Minthon, Michael J Chao, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Elaine R Peskind, Gail Li, Lea K Davis, Julia M Sealock, Nancy J Cox, Alison M Goate, David A Bennett, Julie A Schneider, Angela L Jefferson, Carlos Cruchaga, Timothy J Hohman
Cerebrospinal fluid (CSF) levels of amyloid-β 42 (Aβ42) and tau have been evaluated as endophenotypes in Alzheimer's disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not been evaluated in genetic studies of AD endophenotypes. We performed sex-stratified and sex interaction genetic analyses of CSF biomarkers to identify sex-specific associations. Data came from a previous genome-wide association study (GWAS) of CSF Aβ42 and tau (1527 males, 1509 females). We evaluated sex interactions at previous loci, performed sex-stratified GWAS to identify sex-specific associations, and evaluated sex interactions at sex-specific GWAS loci...
July 2, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29948962/the-parker-model-applying-a-qualitative-three-step-approach-to-optimally-utilize-input-from-stakeholders-when-introducing-new-device-technologies-in-the-management-of-chronic-rheumatic-diseases
#13
Tanja S Jørgensen, Marie Skougaard, Peter C Taylor, Hans C Asmussen, Anne Lee, Louise Klokker, Louise Svejstrup, Irina Mountian, Henrik Gudbergsen, Lars Erik Kristensen
BACKGROUND AND OBJECTIVE: Qualitative methods such as semi-structured interviews and focus-groups are used to evaluate the applicability and relevance of device technologies in clinical practice, but when used alone, often lack generalizability. This study aimed to assess the face validity and feasibility of using a composite, three-step qualitative method (the Parker Model), to inform the development and implementation of ava® , an electromechanical device (e-Device) for subcutaneous self-administration of the biologic, certolizumab pegol (CZP), used to treat rheumatic diseases...
June 11, 2018: Patient
https://www.readbyqxmd.com/read/29945077/trauma-informed-schools-child-disaster-exposure-community-violence-and-somatic-symptoms
#14
Betty S Lai, Melissa C Osborne, NaeHyung Lee, Shannon Self-Brown, Ann-Margaret Esnard, Mary Lou Kelley
BACKGROUND: Given the increasing prevalence of natural disasters, trauma-informed school settings should include efficient methods for assessing child health and mental health in post-disaster environments. To develop such methods, factors that contribute to children's vulnerability and key signs of distress reactions after disasters need to be understood. To address these issues, we evaluated pre-disaster community violence exposure as a vulnerability factor for children's post-disaster reactions and somatic symptoms as a key post-disaster outcome...
June 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29934512/maternal-short-stature-and-under-weight-status-are-independent-risk-factors-for-preterm-birth-and-small-for-gestational-age-in-rural-bangladesh
#15
Rasheda Khanam, Anne Cc Lee, Dipak K Mitra, Malathi Ram, Sushil Das Gupta, Abdul Quaiyum, Allysha Choudhury, Parul Christian, Luke C Mullany, Abdullah H Baqui
BACKGROUND/OBJECTIVES: To estimate the risks of term-small for gestational age (SGA), preterm-appropriate for gestational age (AGA), and preterm SGA associated with maternal height and body mass index (BMI) and to calculate the population attributable fractions (PAF) of term SGA, preterm AGA, and preterm SGA associated with maternal short stature. SUBJECTS/METHODS: A population-based cohort of 13,230 women with pre-pregnancy height and weight followed from 2012 to 2016 in Sylhet, Bangladesh...
June 22, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29930110/analysis-of-shared-heritability-in-common-disorders-of-the-brain
#16
Verneri Anttila, Brendan Bulik-Sullivan, Hilary K Finucane, Raymond K Walters, Jose Bras, Laramie Duncan, Valentina Escott-Price, Guido J Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H Lee, Patrick Turley, Benjamin Grenier-Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland, Jean-François Deleuze, Emmanuelle Duron, Badri N Vardarajan, Christiane Reitz, Alison M Goate, Matthew J Huentelman, M Ilyas Kamboh, Eric B Larson, Ekaterina Rogaeva, Peter St George-Hyslop, Hakon Hakonarson, Walter A Kukull, Lindsay A Farrer, Lisa L Barnes, Thomas G Beach, F Yesim Demirci, Elizabeth Head, Christine M Hulette, Gregory A Jicha, John S K Kauwe, Jeffrey A Kaye, James B Leverenz, Allan I Levey, Andrew P Lieberman, Vernon S Pankratz, Wayne W Poon, Joseph F Quinn, Andrew J Saykin, Lon S Schneider, Amanda G Smith, Joshua A Sonnen, Robert A Stern, Vivianna M Van Deerlin, Linda J Van Eldik, Denise Harold, Giancarlo Russo, David C Rubinsztein, Anthony Bayer, Magda Tsolaki, Petra Proitsi, Nick C Fox, Harald Hampel, Michael J Owen, Simon Mead, Peter Passmore, Kevin Morgan, Markus M Nöthen, Martin Rossor, Michelle K Lupton, Per Hoffmann, Johannes Kornhuber, Brian Lawlor, Andrew McQuillin, Ammar Al-Chalabi, Joshua C Bis, Agustin Ruiz, Mercè Boada, Sudha Seshadri, Alexa Beiser, Kenneth Rice, Sven J van der Lee, Philip L De Jager, Daniel H Geschwind, Matthias Riemenschneider, Steffi Riedel-Heller, Jerome I Rotter, Gerhard Ransmayr, Bradley T Hyman, Carlos Cruchaga, Montserrat Alegret, Bendik Winsvold, Priit Palta, Kai-How Farh, Ester Cuenca-Leon, Nicholas Furlotte, Tobias Kurth, Lannie Ligthart, Gisela M Terwindt, Tobias Freilinger, Caroline Ran, Scott D Gordon, Guntram Borck, Hieab H H Adams, Terho Lehtimäki, Juho Wedenoja, Julie E Buring, Markus Schürks, Maria Hrafnsdottir, Jouke-Jan Hottenga, Brenda Penninx, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Eija Hämäläinen, Hailiang Huang, Jie Huang, Cynthia Sandor, Caleb Webber, Bertram Muller-Myhsok, Stefan Schreiber, Veikko Salomaa, Elizabeth Loehrer, Hartmut Göbel, Alfons Macaya, Patricia Pozo-Rosich, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Andres Metspalu, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Arn M J M van den Maagdenberg, John-Anker Zwart, Dorret Boomsma, Nicholas Eriksson, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Andreja Avbersek, Larry Baum, Samuel Berkovic, Jonathan Bradfield, Russell Buono, Claudia B Catarino, Patrick Cossette, Peter De Jonghe, Chantal Depondt, Dennis Dlugos, Thomas N Ferraro, Jacqueline French, Helle Hjalgrim, Jennifer Jamnadas-Khoda, Reetta Kälviäinen, Wolfram S Kunz, Holger Lerche, Costin Leu, Dick Lindhout, Warren Lo, Daniel Lowenstein, Mark McCormack, Rikke S Møller, Anne Molloy, Ping-Wing Ng, Karen Oliver, Michael Privitera, Rodney Radtke, Ann-Kathrin Ruppert, Thomas Sander, Steven Schachter, Christoph Schankin, Ingrid Scheffer, Susanne Schoch, Sanjay M Sisodiya, Philip Smith, Michael Sperling, Pasquale Striano, Rainer Surges, G Neil Thomas, Frank Visscher, Christopher D Whelan, Federico Zara, Erin L Heinzen, Anthony Marson, Felicitas Becker, Hans Stroink, Fritz Zimprich, Thomas Gasser, Raphael Gibbs, Peter Heutink, Maria Martinez, Huw R Morris, Manu Sharma, Mina Ryten, Kin Y Mok, Sara Pulit, Steve Bevan, Elizabeth Holliday, John Attia, Thomas Battey, Giorgio Boncoraglio, Vincent Thijs, Wei-Min Chen, Braxton Mitchell, Peter Rothwell, Pankaj Sharma, Cathie Sudlow, Astrid Vicente, Hugh Markus, Christina Kourkoulis, Joana Pera, Miriam Raffeld, Scott Silliman, Vesna Boraska Perica, Laura M Thornton, Laura M Huckins, N William Rayner, Cathryn M Lewis, Monica Gratacos, Filip Rybakowski, Anna Keski-Rahkonen, Anu Raevuori, James I Hudson, Ted Reichborn-Kjennerud, Palmiero Monteleone, Andreas Karwautz, Katrin Mannik, Jessica H Baker, Julie K O'Toole, Sara E Trace, Oliver S P Davis, Sietske G Helder, Stefan Ehrlich, Beate Herpertz-Dahlmann, Unna N Danner, Annemarie A van Elburg, Maurizio Clementi, Monica Forzan, Elisa Docampo, Jolanta Lissowska, Joanna Hauser, Alfonso Tortorella, Mario Maj, Fragiskos Gonidakis, Konstantinos Tziouvas, Hana Papezova, Zeynep Yilmaz, Gudrun Wagner, Sarah Cohen-Woods, Stefan Herms, Antonio Julià, Raquel Rabionet, Danielle M Dick, Samuli Ripatti, Ole A Andreassen, Thomas Espeseth, Astri J Lundervold, Vidar M Steen, Dalila Pinto, Stephen W Scherer, Harald Aschauer, Alexandra Schosser, Lars Alfredsson, Leonid Padyukov, Katherine A Halmi, James Mitchell, Michael Strober, Andrew W Bergen, Walter Kaye, Jin Peng Szatkiewicz, Bru Cormand, Josep Antoni Ramos-Quiroga, Cristina Sánchez-Mora, Marta Ribasés, Miguel Casas, Amaia Hervas, Maria Jesús Arranz, Jan Haavik, Tetyana Zayats, Stefan Johansson, Nigel Williams, Astrid Dempfle, Aribert Rothenberger, Jonna Kuntsi, Robert D Oades, Tobias Banaschewski, Barbara Franke, Jan K Buitelaar, Alejandro Arias Vasquez, Alysa E Doyle, Andreas Reif, Klaus-Peter Lesch, Christine Freitag, Olga Rivero, Haukur Palmason, Marcel Romanos, Kate Langley, Marcella Rietschel, Stephanie H Witt, Soeren Dalsgaard, Anders D Børglum, Irwin Waldman, Beth Wilmot, Nikolas Molly, Claiton H D Bau, Jennifer Crosbie, Russell Schachar, Sandra K Loo, James J McGough, Eugenio H Grevet, Sarah E Medland, Elise Robinson, Lauren A Weiss, Elena Bacchelli, Anthony Bailey, Vanessa Bal, Agatino Battaglia, Catalina Betancur, Patrick Bolton, Rita Cantor, Patrícia Celestino-Soper, Geraldine Dawson, Silvia De Rubeis, Frederico Duque, Andrew Green, Sabine M Klauck, Marion Leboyer, Pat Levitt, Elena Maestrini, Shrikant Mane, Daniel Moreno- De-Luca, Jeremy Parr, Regina Regan, Abraham Reichenberg, Sven Sandin, Jacob Vorstman, Thomas Wassink, Ellen Wijsman, Edwin Cook, Susan Santangelo, Richard Delorme, Bernadette Rogé, Tiago Magalhaes, Dan Arking, Thomas G Schulze, Robert C Thompson, Jana Strohmaier, Keith Matthews, Ingrid Melle, Derek Morris, Douglas Blackwood, Andrew McIntosh, Sarah E Bergen, Martin Schalling, Stéphane Jamain, Anna Maaser, Sascha B Fischer, Céline S Reinbold, Janice M Fullerton, José Guzman-Parra, Fermin Mayoral, Peter R Schofield, Sven Cichon, Thomas W Mühleisen, Franziska Degenhardt, Johannes Schumacher, Michael Bauer, Philip B Mitchell, Elliot S Gershon, John Rice, James B Potash, Peter P Zandi, Nick Craddock, I Nicol Ferrier, Martin Alda, Guy A Rouleau, Gustavo Turecki, Roel Ophoff, Carlos Pato, Adebayo Anjorin, Eli Stahl, Markus Leber, Piotr M Czerski, Cristiana Cruceanu, Ian R Jones, Danielle Posthuma, Till F M Andlauer, Andreas J Forstner, Fabian Streit, Bernhard T Baune, Tracy Air, Grant Sinnamon, Naomi R Wray, Donald J MacIntyre, David Porteous, Georg Homuth, Margarita Rivera, Jakob Grove, Christel M Middeldorp, Ian Hickie, Michele Pergadia, Divya Mehta, Johannes H Smit, Rick Jansen, Eco de Geus, Erin Dunn, Qingqin S Li, Matthias Nauck, Robert A Schoevers, Aartjan Tf Beekman, James A Knowles, Alexander Viktorin, Paul Arnold, Cathy L Barr, Gabriel Bedoya-Berrio, O Joseph Bienvenu, Helena Brentani, Christie Burton, Beatriz Camarena, Carolina Cappi, Danielle Cath, Maria Cavallini, Daniele Cusi, Sabrina Darrow, Damiaan Denys, Eske M Derks, Andrea Dietrich, Thomas Fernandez, Martijn Figee, Nelson Freimer, Gloria Gerber, Marco Grados, Erica Greenberg, Gregory L Hanna, Andreas Hartmann, Matthew E Hirschtritt, Pieter J Hoekstra, Alden Huang, Chaim Huyser, Cornelia Illmann, Michael Jenike, Samuel Kuperman, Bennett Leventhal, Christine Lochner, Gholson J Lyon, Fabio Macciardi, Marcos Madruga-Garrido, Irene A Malaty, Athanasios Maras, Lauren McGrath, Eurípedes C Miguel, Pablo Mir, Gerald Nestadt, Humberto Nicolini, Michael S Okun, Andrew Pakstis, Peristera Paschou, John Piacentini, Christopher Pittenger, Kerstin Plessen, Vasily Ramensky, Eliana M Ramos, Victor Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Veit Roessner, Maria Rosário, Jack F Samuels, Paul Sandor, Dan J Stein, Fotis Tsetsos, Filip Van Nieuwerburgh, Sarah Weatherall, Jens R Wendland, Tomasz Wolanczyk, Yulia Worbe, Gwyneth Zai, Fernando S Goes, Nicole McLaughlin, Paul S Nestadt, Hans-Jorgen Grabe, Christel Depienne, Anuar Konkashbaev, Nuria Lanzagorta, Ana Valencia-Duarte, Elvira Bramon, Nancy Buccola, Wiepke Cahn, Murray Cairns, Siow A Chong, David Cohen, Benedicto Crespo-Facorro, James Crowley, Michael Davidson, Lynn DeLisi, Timothy Dinan, Gary Donohoe, Elodie Drapeau, Jubao Duan, Lieuwe Haan, David Hougaard, Sena Karachanak-Yankova, Andrey Khrunin, Janis Klovins, Vaidutis Kučinskas, Jimmy Lee Chee Keong, Svetlana Limborska, Carmel Loughland, Jouko Lönnqvist, Brion Maher, Manuel Mattheisen, Colm McDonald, Kieran C Murphy, Igor Nenadic, Jim van Os, Christos Pantelis, Michele Pato, Tracey Petryshen, Digby Quested, Panos Roussos, Alan R Sanders, Ulrich Schall, Sibylle G Schwab, Kang Sim, Hon-Cheong So, Elisabeth Stögmann, Mythily Subramaniam, Draga Toncheva, John Waddington, James Walters, Mark Weiser, Wei Cheng, Robert Cloninger, David Curtis, Pablo V Gejman, Frans Henskens, Morten Mattingsdal, Sang-Yun Oh, Rodney Scott, Bradley Webb, Gerome Breen, Claire Churchhouse, Cynthia M Bulik, Mark Daly, Martin Dichgans, Stephen V Faraone, Rita Guerreiro, Peter Holmans, Kenneth S Kendler, Bobby Koeleman, Carol A Mathews, Alkes Price, Jeremiah Scharf, Pamela Sklar, Julie Williams, Nicholas W Wood, Chris Cotsapas, Aarno Palotie, Jordan W Smoller, Patrick Sullivan, Jonathan Rosand, Aiden Corvin, Benjamin M Neale
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders...
June 22, 2018: Science
https://www.readbyqxmd.com/read/29930091/coactivator-condensation-at-super-enhancers-links-phase-separation-and-gene-control
#17
Benjamin R Sabari, Alessandra Dall'Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey, Krishna Shrinivas, Brian J Abraham, Nancy M Hannett, Alicia V Zamudio, John C Manteiga, Charles H Li, Yang E Guo, Daniel S Day, Jurian Schuijers, Eliza Vasile, Sohail Malik, Denes Hnisz, Tong Ihn Lee, Ibrahim I Cisse, Robert G Roeder, Phillip A Sharp, Arup K Chakraborty, Richard A Young
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here, we demonstrate that the SE-enriched transcriptional coactivators BRD4 and MED1 form nuclear puncta at SEs that exhibit properties of liquid-like condensates and are disrupted by chemicals that perturb condensates. The intrinsically disordered regions (IDRs) of BRD4 and MED1 can form phase-separated droplets and MED1-IDR droplets can compartmentalize and concentrate transcription apparatus from nuclear extracts...
June 21, 2018: Science
https://www.readbyqxmd.com/read/29926297/breast-cancer-in-women-with-neurofibromatosis-type-1-nf1-a-comprehensive-case-series-with-molecular-insights-into-its-aggressive-phenotype
#18
Yoon-Sim Yap, Prabhakaran Munusamy, Cindy Lim, Claire H T Chan, Aldo Prawira, Sau-Yeen Loke, Swee-Ho Lim, Kong-Wee Ong, Wei-Sean Yong, Sarah B H Ng, Iain B H Tan, David F Callen, Jeffrey C T Lim, Aye-Aye Thike, Puay-Hoon Tan, Ann S G Lee
PURPOSE: The purpose of the study was to improve the understanding of NF1-associated breast cancer, given the increased risk of breast cancer in this tumour predisposition syndrome and the limited data. METHODS: We identified 18 women with NF1 and breast cancer at our institution. Clinical and pathologic characteristics of NF1-associated breast cancers were compared with 7132 breast cancers in patients without NF1 from our institutional database. Next generation sequencing was performed on DNA from blood and breast cancer specimens available...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29922520/magnetic-resonance-guided-inter-fraction-monitoring-opens-doors-to-delivering-safer-reirradiation-an-illustrative-case-report-and-discussion
#19
Rebecca Levin-Epstein, Minsong Cao, Percy Lee, Michael L Steinberg, James Lamb, Ann C Raldow
Locoregional recurrence in the pelvis after definitive treatment for rectal cancer can lead to significant morbidity. Furthermore, the toxicity associated with reirradiation may also negatively impact the quality of life and even survival. Here we present the case of a 39-year-old male with locoregionally recurrent rectal cancer in a left pelvic sidewall lymph node, treated with stereotactic magnetic resonance (MR)-guided ablative radiotherapy after previously receiving long-course chemoradiation that had already exceeded ideal bowel dose constraints...
April 14, 2018: Curēus
https://www.readbyqxmd.com/read/29920313/inflammatory-bowel-disease-events-after-exposure-to-the-il-17-inhibitors-secukinumab-and-ixekizumab-a-post-marketing-analysis-from-the-radar-research-on-adverse-drug-events-and-reports-program
#20
Kelsey A Orrell, Morgan Murphrey, Ryan C Kelm, Harrison H Lee, David R Pease, Anne E Laumann, Dennis P West, Beatrice Nardone
No abstract text is available yet for this article.
June 16, 2018: Journal of the American Academy of Dermatology
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