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Yohan Kim, Kyojin Kang, Seung Bum Lee, Daekwan Seo, Sangtae Yoon, Heung Mo Yang, Sung Joo Kim, Kiseok Jang, Yun Kyung Jung, Kyeong Geun Lee, Valentina M Factor, Jaemin Jeong, Dongho Choi
BACKGROUND & AIMS: Currently, much effort is directed towards the development of new cell sources for clinical therapy using cell fate conversion approaches by small molecules. Direct lineage reprogramming to a progenitor state has been reported in terminally differentiated rodent hepatocytes, yet remains a challenge in human hepatocytes. METHODS: Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor cells by two small molecules, A83-01 and CHIR99021 (AC), in the presence of EGF and HGF...
September 18, 2018: Journal of Hepatology
Elmira Baghdasaryan, Tudor C Tepelus, Kenneth M Marion, Jianyan Huang, Ping Huang, SriniVas R Sadda, Olivia L Lee
PURPOSE: To evaluate the utility of swept-source (SS) optical coherence tomography (OCT) to objectively analyze the degree of anterior chamber (AC) inflammation. METHODS: Thirty-eight eyes of 32 patients with uveitis and 20 control eyes were enrolled. SS OCT B-scans were obtained, and the number of cells in the B-scans was counted using two methods: (1) manual grading by Point Picker plug-in of Image J ( ) and (2) automated grading by the Image J Particle Analysis algorithm ( http://imagej...
September 20, 2018: International Ophthalmology
Cheol Soo Yoon, Min Keun Kim, Yeon Sook Kim, Suk Keun Lee
RAW 264.7 cells and HUVECs were compared to evaluate the effects of dialyzed coffee extract (DCE) and artificial coffee (AC). Immunoprecipitation high performance liquid chromatography (IP-HPLC) showed DCE-2.5- (equivalent to 2.5 cups of coffee a day) and DCE-5-induced protein expression that was beneficial to human health, i.e., they led to significant increases in proliferation-, immunity-, cellular protection-, antioxidant signaling-, and osteogenesis-related proteins but decreases in inflammation-, NFkB signaling-, cellular apoptosis-, and oncogenic signaling-related proteins in RAW 264...
September 14, 2018: Scientific Reports
Biswa Nath Bhadra, Ji Yoon Song, Su-Kyung Lee, Young Kyu Hwang, Sung Hwa Jhung
Metal azolate framework-6 (MAF-6) was pyrolyzed at 1000°C to yield MOF-derived carbons (MCs). The obtained MCs were used to eliminate aromatic hydrocarbons, including polyaromatic hydrocarbons (PAHs; e.g., naphthalene (NAP), anthracene (ATC), and pyrene (PRN)) and benzene (BZ) from water via adsorption. The adsorption results over the MCs were compared with that of pristine MAF-6 and commercial activated carbon (AC). MC obtained after 24h (MC-24) exhibited a remarkable adsorption efficiency compared to that of the other MCs (obtained after different durations), MAF-6, and AC...
February 15, 2018: Journal of Hazardous Materials
Song Yi Lee, Suyeong Nam, Sungyun Kim, Ja Seong Koo, In Kee Hong, Hill Kim, Sangin Han, Minji Kang, Heejung Yang, Hyun-Jong Cho
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 ( p < 0...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Juhyung Lee, Yeon Uk Ko, Yuhyun Chung, Nuri Yun, Myungjin Kim, Kyungjin Kim, Young J Oh
Cyclin-dependent kinase 5 (CDK5) plays a pivotal role in neural development and neurodegeneration. CDK5 activity can be regulated by posttranslational modifications, including phosphorylation and S-nitrosylation. In this study, we demonstrate a novel mechanism by which the acetylation of CDK5 at K33 (Ac-CDK5) results in the loss of ATP binding and impaired kinase activity. We identify GCN5 and SIRT1 as critical factor controlling Ac-CDK5 levels. Ac-CDK5 achieved its lowest levels in rat fetal brains but was dramatically increased during postnatal periods...
September 12, 2018: Scientific Reports
Jiyun Lee, Kyung R Sung, Junki Kwon, Joong W Shin
PURPOSE: To assess whether the use of antiplatelets (APs)/anticoagulants (ACs) affects glaucoma progression in eyes with optic disc hemorrhage (DH). METHODS: One hundred and nineteen eyes from 119 patients with primary open-angle glaucoma in whom a DH was observed at least once during the follow-up period (mean follow-up duration: 6.2 y) were included in this retrospective observational study. Cox proportional hazard models were used to identify the association between putative factors, including AP/AC use, and glaucoma progression...
September 7, 2018: Journal of Glaucoma
Jong-Gu Choi, Su-Hee Kim, Sang-Suk Lee
A giant magnetoresistance-spin valve (GMR-SV) having highly sensitive magnetic properties was prepared with a multilayer soft ferromagnetic/non-magnetic/pinned ferromagnetic/anti-ferromagnetic iridium manganese (IrMn) top layer (NiFe/CoFe/Cu/CoFe/IrMn) structure. Micron-sized magnetic beads (MBs) with a diameter of 1 μm immersed in a solution containing 50 mg of Co-Si-OH/ml were attached to red blood cells (RBCs) having the very low magnetization of hemoglobin (HEM) to detect a deoxidized RBC combined with MBs (RBC+MBs)...
2018: Advances in Experimental Medicine and Biology
Geon-Tae Hwang, Haribabu Palneedi, Byung Mun Jung, Suk Jin Kwon, Mahesh Peddigari, Yuho Min, Jong-Woo Kim, Cheol-Woo Ahn, Jong-Jin Choi, Byung-Dong Hahn, Joon-Hwan Choi, Woon-Ha Yoon, Dong-Soo Park, Sang-Bok Lee, Youngson Choe, Kwang-Ho Kim, Jungho Ryu
We report the effect of epoxy adhesion layers with different mechanical or physical property on a magnetoelectric (ME) composite laminate composed of FeBSi alloy (Metglas)/single-crystal Pb(Mg1/3 Nb2/3 )O3 -Pb(Zr,Ti)O3 /Metglas to achieve an improved ME conversion performance. Through theoretical simulation, it was revealed that the Young's modulus and the thickness of interfacial adhesives were major parameters that influence the conversion efficiency in ME composites. In the experimental evaluation, we utilized three epoxy materials with a distinct Young's modulus and adjusted the average thickness of the adhesion layers to optimize the ME conversion...
September 12, 2018: ACS Applied Materials & Interfaces
Hyo Won Kwak, Yeonkyung Hong, Min Eui Lee, Hyoung-Joon Jin
Activated carbon has been widely used as an effective adsorbent for removing contaminants from the water stream. Preparation of activated carbon using agricultural by-products is environmentally friendly and can greatly contribute to the virtuous cycle of natural polymers. In this study, highly porous activated carbon was prepared using silk sericin, a secondary protein of the sericulture industry. For easy processability and regeneration stability, the bead-type adsorbent was prepared using alginate (Alg) as a matrix...
August 28, 2018: International Journal of Biological Macromolecules
Leah M Mayo, Anna Asratian, Johan Lindé, Lovisa Holm, Daniel Nätt, Gaëlle Augier, Niclas Stensson, Haley A Vecchiarelli, Georgia Balsevich, Robert J Aukema, Bijar Ghafouri, Primavera A Spagnolo, Francis S Lee, Matthew N Hill, Markus Heilig
Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited treatment options. Extinction of fear memories through prolonged exposure therapy, the primary evidence-based behavioral treatment for PTSD, has only partial efficacy. In mice, pharmacological inhibition of fatty acid amide hydrolase (FAAH) produces elevated levels of anandamide (AEA) and promotes fear extinction, suggesting that FAAH inhibitors may aid fear extinction-based treatments. A human FAAH 385C->A substitution encodes an FAAH enzyme with reduced catabolic efficacy...
August 17, 2018: Molecular Psychiatry
Heeyoun Hwang, Ji Eun Jeong, Hyun Kyoung Lee, Ki Na Yun, Hyun Joo An, Bonghee Lee, Young-Ki Paik, Tae Seok Jeong, Gi Taek Yee, Jin Young Kim, Jong Shin Yoo
We performed proteomic analyses of human olfactory epithelial tissue to identify missing proteins using liquid chromatography-tandem mass spectrometry. Using a next-generation proteomic pipeline with a < 1.0% false discovery rate at the peptide and protein levels, we identified 3731 proteins, among which five were missing proteins (P0C7M7, P46721, P59826, Q658L1, and Q8N434). We validated the identified missing proteins using the corresponding synthetic peptides. No olfactory receptor (OR) proteins were detected in olfactory tissue, suggesting that detection of ORs would be very difficult...
August 20, 2018: Journal of Proteome Research
Minsu Park, Hyewon Yoon, Jaeho Lee, Jungmo Kim, Jinho Lee, Seong-Eui Lee, Seunghyup Yoo, Seokwoo Jeon
Emerging graphene quantum dots (GQDs) have received much attention for use as next-generation light-emitting diodes. However, in the solid-state, π-interaction-induced aggregation-caused photoluminescence (PL) quenching (ACQ) in GQDs makes it challenging to realize high-performance devices. Herein, GQDs incorporated with boron oxynitride (GQD@BNO) are prepared from a mixture of GQDs, boric acid, and urea in water via one-step microwave heating. Due to the effective dispersion in the BNO matrix, ACQ is significantly suppressed, resulting in high PL quantum yields (PL-QYs) of up to 36...
September 2018: Advanced Materials
San-Yuan Chen, Ying-Ray Lee, Ming-Chia Hsieh, Hany A Omar, Yen-Ni Teng, Ching-Yen Lin, Jui-Hsiang Hung
Antrodia cinnamomea ( AC ) is a medicinal fungal species that has been widely used traditionally in Taiwan for the treatment of diverse health-related conditions including cancer. It possesses potent anti-inflammatory and antioxidant properties in addition to its ability to promote cancer cell death in several human tumors. Our aim was to improve the anticancer activity of AC in hepatocellular carcinoma (HCC) through its cocultivation with ginger aiming at tuning the active ingredients. HCC cell lines, Huh-7 and HepG2 were used to study the in vitro anticancer activity of the ethanolic extracts of AC (EAC) alone or after the cocultivation in presence of ginger (EACG)...
2018: Frontiers in Pharmacology
Sangeun Lee, Alexandra Stubelius, Naomi Hamelmann, Vincent Tran, Adah Almutairi
Stimuli-responsive nanomaterials are especially interesting to enhance drug-delivery specificity for biomedical applications. With the aim to achieve a highly stable and inflammation-specific drug release, we designed an reactive oxygen species (ROS)-responsive dextran-drug conjugate (Nap-Dex). By blending Nap-Dex with the acid-sensitive acetalated dextran polymer (Ac-Dex) we achieved a dual responsive nanoparticle with high specificity toward the inflammatory environment. The inflammatory environment not only has elevated ROS levels, but also a lower pH than healthy tissue, making pH and ROS highly suitable triggers to target inflammatory diseases...
August 1, 2018: ACS Applied Materials & Interfaces
Pubudu P Handakumbura, Kathryn Brow, Ian P Whitney, Kangmei Zhao, Karen A Sanguinet, Scott J Lee, Jennifer Olins, Sandra P Romero-Gamboa, Michael J Harrington, Carlisle J Bascom, Kirk J-M MacKinnon, Michael T Veling, Lifeng Liu, Ji E Lee, John P Vogel, Ronan C O'Malley, Magdalena Bezanilla, Laura E Bartley, Samuel P Hazen
Grass biomass is comprised chiefly of secondary walls that surround fiber and xylem cells. A regulatory network of interacting transcription factors in part regulates cell wall thickening. We identified Brachypodium distachyon SECONDARY WALL ASSOCIATED MYB1 (SWAM1) as a potential regulator of secondary cell wall biosynthesis based on gene expression, phylogeny, and transgenic plant phenotypes. SWAM1 interacts with cellulose and lignin gene promoters with preferential binding to AC-rich sequence motifs commonly found in the promoters of cell wall-related genes...
July 27, 2018: Plant Journal: for Cell and Molecular Biology
Huiyoung Kwon, Ji Wook Jung, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
Artemisia capillaris Thunberg is a medicinal plant used as a traditional medicine in many cultures. It is an effective remedy for liver problems including hepatitis. Recent pharmacological reports have indicated that Artemisia species can exert various neurological effects. Previously, we reported a memory-enhancing effect of Artemisia species. However, the mechanisms underlying the neuroprotective effect of A. capillaris (AC) are still unknown. In the present study, we investigated the effect of an ethanol extract of AC on ischemic brain injury in a mouse model of transient forebrain ischemia...
June 2018: Chinese Journal of Natural Medicines
Min Soo Choo, Saangyong Uhmn, Jong Keun Kim, Jun Hyun Han, Dong-Hoi Kim, Jin Kim, Seong Ho Lee
PURPOSE: The aim of this study was to develop and validate a decision support model using machine learning algorithm to predict treatment success after single-session SWL in ureteral stone patients. MATERIALS AND METHODS: Of the 1803 patients treated with SWL, we selected ureteral stone patients with an available preoperative CT scan. Treatment success after single-session SWL was defined as being free of stones or residual stone fragments less than 2 mm in length by CT scan or KUB two weeks later...
July 20, 2018: Journal of Urology
Chia-Chun Hsu, Yan-Chang Lee, Wen-Hsin Hsieh
This study uses negative dielectrophoresis and AC electroosmosis as a driving mechanism and presents an electrically driven microconcentrator that concentrates the sample in the region exterior to the electrodes (termed as exterior-electrode electrically driven microconcentrator in this paper). The proposed microconcentrator uses a 3-D face-to-face electrode pair; the top electrode is a relatively large planar electrode, and the bottom electrode is formed with three to six long and thin electrodes connected into an open ring...
July 13, 2018: Electrophoresis
Ji Yeon Lee, Yoon Jeong Choi, Seong-Ho Choi, Chooryung J Chung, Hyung-Seog Yu, Kyung-Ho Kim
BACKGROUND: Labially impacted maxillary canines may lack periodontal tissue after orthodontic traction. This study evaluated the periodontal status of labially impacted maxillary canines after the closed eruption technique followed by orthodontic traction and investigated pretreatment variables affecting periodontal changes. METHODS: Patients with one labially impacted maxillary canine (impaction group) and one contralateral normal canine (control group) were selected retrospectively...
July 12, 2018: Journal of Periodontology
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