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Sheng-Yao Chang, Ming-Yuan Lee, Ching-Chou Wu
A microchip electrophoresis (ME) device with off-channel contact conductivity detection (C2 D) was constructed using top-bottom antiparallel indium tin oxide (ITO) electrodes and a cross-type microchannel. The 500-m wide top-bottom antiparallel decouplers were found to effectively decrease the interference of the electrophoretic current. The cross-type microchannel was formed by bonding the patterned negative photoresist microstructures and the two top-bottom opposed ITO-deposited glass substrates. Five seconds of 150 V/cm injection field and the 100 V/cm separation field equipped with the C2 D of AC 200 mV excitation voltage provided adequate ME operational parameters to obtain the K+ and Na+ peaks separation...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Sang-Hyun Han, Seung-Hye Baek, Hyun-Jin Lee, Hyunsoo Kim, Sung-Nam Lee
III-nitride semiconductor-based light-emitting diodes (LEDs) have superior physical properties, such as high thermal stability and brightness, for application to solid-state lighting sources. With the commercialization of GaN-based LEDs, improving LED reliability is important because they can be affected by electrostatic discharge, reverse leakage, and breakdown. However, research on the reverse bias characteristics of GaN-based LEDs is insufficient. We studied the reverse breakdown mechanism and demonstrated that a local breakdown can form a conductive channel in GaN-based LEDs, which can be expanded to a novel planar-type LED structure without an n-contact electrode...
November 8, 2018: Scientific Reports
Jong Ik Lee, Dongwon Kang, Seok Hwan Kong, Hyogi Gim, Ik-Soo Shin, Jungwook Kim, Moon Sung Kang
Electrochemiluminescence (ECL) involves light emission accompanied by a series of electrochemical processes on luminophores, which has been recently exploited in a new light-emitting device platform, referred to as the ECL device (ECLD). Here, we investigate the influence of the transport of the ECL luminophores and their reaction kinetics on the emission properties of AC-voltage-driven ECLDs. A model based on the diffusion and reaction rate equations is developed to predict the operational frequency (f)-dependent luminance properties of the ECLD...
November 6, 2018: ACS Applied Materials & Interfaces
Toshiaki Hirakata, Hyeon-Cheol Lee, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Akira Murakami, Akira Matsuda, Takehiko Yokomizo
Allergic conjunctivitis (AC) is one of the most common ocular surface diseases in the world. In AC, T helper type 2 (Th 2) immune responses play central roles in orchestrating inflammatory responses. However, the roles of lipid mediators in the onset and progression of AC remain to be fully explored. Although previous reports have shown the beneficial effects of supplementation of ω-3 fatty acids in asthma or atopic dermatitis, the underlying molecular mechanisms are poorly understood. In this study, a diet rich in ω-3 fatty acids alleviated AC symptoms in both early and late phases without affecting Th 2 immune responses, but rather by altering the lipid mediator profiles...
November 1, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Valerie F Weed, Katia Canenguez, Stephanie Romo, Shirley L Wang, Lewis Kazis, Austin F Lee, David Herndon, Tina L Palmieri, Petra Warner, Haregnesh Haile, Robert L Sheridan, J Michael Murphy
Burns are among the most common injuries to children and, although survival rates have improved, many burn survivors are left with scars and/or other visible differences, which may be associated with anxiety, depression, and/or low self-esteem. A better understanding of the prevalence and persistence of these problems in child and adolescent burn survivors might lead to an expanded paradigm of care and possibly to better outcomes. The current study provides longitudinal prevalence data for the Appearance Concerns (AC) subscale of the parent-reported Burn Outcomes Questionnaire for 5-18 year olds and identifies patient characteristics associated with higher risk for appearance concerns...
October 29, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Rodabe N Amaria, Sangeetha M Reddy, Hussein A Tawbi, Michael A Davies, Merrick I Ross, Isabella C Glitza, Janice N Cormier, Carol Lewis, Wen-Jen Hwu, Ehab Hanna, Adi Diab, Michael K Wong, Richard Royal, Neil Gross, Randal Weber, Stephen Y Lai, Richard Ehlers, Jorge Blando, Denái R Milton, Scott Woodman, Robin Kageyama, Daniel K Wells, Patrick Hwu, Sapna P Patel, Anthony Lucci, Amy Hessel, Jeffrey E Lee, Jeffrey Gershenwald, Lauren Simpson, Elizabeth M Burton, Liberty Posada, Lauren Haydu, Linghua Wang, Shaojun Zhang, Alexander J Lazar, Courtney W Hudgens, Vancheswaran Gopalakrishnan, Alexandre Reuben, Miles C Andrews, Christine N Spencer, Victor Prieto, Padmanee Sharma, James Allison, Michael T Tetzlaff, Jennifer A Wargo
In the version of this article originally published, there was an error in Fig. 1. In the neoadjuvant phase column, the n values for arms A and B were both reported to be 20. The n values for arms A and B were actually 12 and 11, respectively. Also, the URL underlying the accession code in the data availability section was incorrect. The URL was originally It should have been The errors have been corrected in the print, HTML and PDF versions of this article...
October 25, 2018: Nature Medicine
Woo Jin Lee, Joshua Lee, Min Hyeok Kim, Ludwig Erik Aguilar, Chan Hee Park, Cheol Sang Kim
A new nano air filter for fine dust filtration with antibacterial and volatile organic compounds (VOCs) adsorption properties was fabricated using a bottom-up, high-speed electrospinning system. To optimize production, polyurethane fibers were electrospun at various voltages on polypropylene nonwoven fabrics, and results show that fiber diameter decreased as voltage increased. Silver nanoparticles (AgNPs) and Activated Carbon (AC) were used as antimicrobials and VOC-reducing agents. FTIR, SEM, and EDS were performed to analyze the resulting filter fabricated by electrospinning...
February 1, 2019: Journal of Nanoscience and Nanotechnology
Jin-Sung Jung, Ji-Yun Hong, Hyung-Hoon Oh, Sun-Seog Kweon, Jun Lee, Sang-Wook Kim, Geom-Seog Seo, Hyun-Soo Kim, Young-Eun Joo
BACKGROUND: Colorectal laterally spreading tumors (LSTs) are large, flat neoplasms that are usually treated using different endoscopic techniques based on their morphology, size, and histology. The aim of this study was to evaluate the clinical outcomes of LSTs with advanced histology treated by endoscopic resection. METHODS: A total of 246 LSTs with advanced histology [i.e., high-grade dysplasia (HGD) and adenocarcinoma (AC)] treated by endoscopic resection [i...
October 22, 2018: Surgical Endoscopy
Seungyeop Choi, Kwanhwi Ko, Jongwon Lim, Sung Hoon Kim, Sung-Hun Woo, Yoon Suk Kim, Jaehong Key, Sei Young Lee, In Su Park, Sang Woo Lee
Characterization of cellular dielectrophoretic (DEP) behaviors, when cells are exposed to an alternating current (AC) electric field of varying frequency, is fundamentally important to many applications using dielectrophoresis. However, to date, that characterization has been performed with monotonically increasing or decreasing frequency, not with successive increases and decreases, even though cells might behave differently with those frequency modulations due to the nonlinear cellular electrodynamic responses reported in previous works...
October 19, 2018: Sensors
Tae Hyung Kim, Gwang-Myeong Go, Hong-Baek Cho, Yoseb Song, Chan-Gi Lee, Yong-Ho Choa
Nitrogen doped TiO2 (N-TiO2 ) nanoparticles were synthesized via a novel plasma enhanced electrolysis method using bulk titanium (Ti) as a source material and nitric acid as the nitrogen dopant. This method possesses remarkable merits with regard to the direct-metal synthesis of nanoparticles with its one-step process, eco-friendliness, and its ability to be mass produced. The nanoparticles were synthesized from bulk Ti metal and dipped in 5-15 mmol of a nitric acid electrolyte under the application of AC 500 V, the minimum range of voltage to generate plasma...
2018: Frontiers in Chemistry
Karl N Blodgett, Joshua L Fischer, Jaeyeon Lee, Soo Hyuk Choi, Timothy S Zwier
The infrared and ultraviolet spectra of a series of capped asparagine-containing peptides, Ac-Asn-NHBn, Ac-Ala-Asn-NHBn, and Ac-Asn-Asn-NHBn, have been recorded under jet-cooled conditions in the gas phase in order to probe the influence of the Asn residue, with its -CH2 -C(═O)-NH2 side chain, on the local conformational preferences of a peptide backbone. The double-resonance methods of resonant ion-dip infrared (RIDIR) spectroscopy and infrared-ultraviolet hole-burning (IR-UV HB) spectroscopy were used to record single-conformation spectra in the infrared and ultraviolet, respectively, free from interference from other conformations present in the molecular beam...
November 8, 2018: Journal of Physical Chemistry. A
Miso Kang, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Jong Ho Lee
BACKGROUND: Using metabolomics technique to analyze the response to a dietary intervention generates valuable information concerning the effects of the prescribed diet on metabolic regulation. To determine whether low calorie diet (LCD)-induced weight reduction causes changes in plasma metabolites and metabolic characteristics. METHODS: Overweight subjects consumed a LCD (n = 47) or a weight maintenance diet (control, n = 50) in a randomized, controlled design study with a 12-week clinical intervention period...
October 15, 2018: Lipids in Health and Disease
R Romero-Díez, M Matos, L Rodrigues, Maria R Bronze, S Rodríguez-Rojo, M J Cocero, A A Matias
Wine lees are rich in anthocyanins (AC), natural colorants with health promoting properties. The extraction kinetics of AC from different wine lees in conventional solid-liquid extraction were studied for the first time. The influence of parameters such as temperature, solid-liquid ratio (RS-L ) and type of solvent (hydro-alcoholic mixtures) was also studied. Furthermore, microwaves (MW) and ultrasounds (US) were used as pre-treatments (a prior step to the conventional extraction) in order to increase AC yield...
January 30, 2019: Food Chemistry
In Park, Yasuo Itami, Bobak Hedayati, Benjamin Bitner, Michelle H McGarry, Thay Q Lee, Sang-Jin Shin
PURPOSE: To compare the acromioclavicular (AC) joint stability of single-bundle (SB), double-bundle with an anterolateral limb (DBa), double-bundle with a posterolateral limb (DBp), and triple-bundle (TB) coracoclavicular (CC) ligament reconstructions using cortical fixation buttons with suture tapes. METHODS: Eight cadaveric shoulders were used. AC joint translation and rotational stability were tested for intact and following 4 different CC reconstruction techniques: SB, DBa, DBp, and TB configurations using cortical fixation buttons with suture tapes...
November 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Hanju Oh, Seung-Wook Lee, Minsoo Kim, Woo Seok Lee, Mingi Seong, Hyungmok Joh, Mark G Allen, Gary S May, Muhannad S Bakir, Soong Ju Oh
We introduce solution-based, room temperature- and atmospheric pressure-processed silver nanocrystal (Ag NC)-based electrical circuits and interconnects for radio frequency (RF)/microwave frequency applications. We chemically designed the surface and interface states of Ag NC thin films to achieve high stability, dc and ac conductivity, and minimized RF loss through stepwise ligand exchange, shell coating, and surface cleaning. The chemical and structural properties of the circuits and interconnects affect the high-frequency electrical performance of Ag NC thin films, as confirmed by high-frequency electromagnetic field simulations...
October 31, 2018: ACS Applied Materials & Interfaces
Jae-Seok Min, Chang Min Lee, Sung Il Choi, Kyung Won Seo, Do Joong Park, Yong Hae Baik, Myoung-Won Son, Won Hyuk Choi, Sungsoo Kim, Kyung Ho Pak, Min Gyu Kim, Joong-Min Park, Sang Ho Jeong, Moon-Soo Lee, Sungsoo Park
Purpose: To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and the difference in efficacy of AC administered by surgical and medical oncologists in patients with stage II or III gastric cancers. Materials and Methods: We performed a retrospective observational study among 1,049 patients who underwent curative resection and received AC for stage II and III gastric cancers between February 2012 and December 2013 at 29 tertiary referral university hospitals in Korea...
September 2018: Journal of Gastric Cancer
Giup Jang, Taekeon Lee, Soyoun Hwang, Chihyun Park, Jaegyoon Ahn, Sukyung Seo, Youhyeon Hwang, Youngmi Yoon
The process of discovering novel drugs to treat diseases requires a long time and high cost. It is important to understand side effects of drugs as well as their therapeutic effects, because these can seriously damage the patients due to unexpected actions of the derived candidate drugs. In order to overcome these limitations, computational methods for predicting the therapeutic effects and side effects have been proposed. In particular, text mining is a widely used technique in the field of systems biology, because it can discover hidden relationships between drugs, genes and diseases from a large amount of literature data...
September 27, 2018: Journal of Biomedical Informatics
Ho Jin Kim, Mi Jin Lee, Hye Jin Park, Hye Jin Kim, Soon Kil Cho, Min Hee Jeong
A new analytical method was developed for the simultaneous determination of seven food additives (Ponceau 4R, Allura Red AC, Amaranth, 4-hydroxymethyl benzoic acid, ethyl-4-hydroxybenzoate, butyl-4-hydroxybenzoate, and saccharin sodium) in kimchi using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. The linearity, sensitivity, selectivity, precision, and accuracy of the method were validated. The limit of detection was 0.00004-0.24 μg/mL, and the limit of quantification was 0...
June 2018: Food Science and Biotechnology
Rongying Zhu, Xiaodong Yang, Xiang Xue, Mingjing Shen, Feng Chen, Xiaodong Chen, Ying Tsai, Peter C Keng, Yongbing Chen, Soo Ok Lee, Yuhchyau Chen
Radiation treatment induces neuroendocrine differentiation (NED) in non-small cell lung cancer (NSCLC) A549 and H157 cells, so higher NE-like features in radioresistant A549 (A549R26-1) and H157 (H157R24-1) cells are observed than in parental cells. We detected higher NED marker expressions in A549R26-1 cell-derived tumors than in A549 cell-derived tumors. In mechanism studies, we found that NED induction in A549R26-1 and H157R24-1 cells was accompanied by increased intracellular cAMP and IL-6 levels. Treatment of radioresistant lung cancer cells with the inhibitor (SQ22536) of adenylate cyclase (AC) which is the enzyme responsible for the cAMP production, or the neutralizing antibody (Ab) of IL-6, resulted in decreased NE-like features in radioresistant lung cancer cells...
September 15, 2018: Biochimica et biophysica acta. Molecular cell research
Seung-Ho Lee, Yoon-Jin Cho, Kyung-Joo Cho, Mee-Hyang Ko, Sun-Young Jung, Seung-Joo Chon, So-Yi Lim, Kwang-Beom Lee
Objective: Gynecologic oncologists are uncertain about the safety of tibolone application in cervical adenocarcinoma (AC) patients. This study examined the possible adverse effects of tibolone on the survival of cervical AC patients. Methods: Medical records of 70 cervical AC patients with International Federation of Gynecology and Obstetrics stages IA to IB were reviewed. A bilateral salpingo-oophorectomy was performed in all patients, and survival outcomes between tibolone users (n=38) and non-users (n=32) were compared...
September 2018: Obstetrics & Gynecology Science
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