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https://www.readbyqxmd.com/read/29138786/electroconvection-of-pure-nematic-liquid-crystals-without-free-charge-carriers
#1
Kuang-Wu Lee, Thorsten Pöschel
We consider electroconvection as a response of nematic liquid crystals to an external electric AC field, in the absence of free charge carriers. Previous experimental and theoretical results emphasized charge carriers as a necessary precondition of electroconvection because free-charges in the fluid can respond to an external electric field. Therefore, ionized molecules are considered as responsible for the driving of electroconvective flows. In experiments, finite conductivity is achieved by adding charge-carrying dye molecules or in non-dyed liquid crystals by impurities of the samples...
November 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/29138698/soluble-epoxide-hydrolase-inhibitor-and-14-15-epoxyeicosatrienoic-acid-facilitated-long-term-potentiation-through-camp-and-camkii-in-the-hippocampus
#2
Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin
Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH). The role of EETs in synaptic function in the central nervous system is still largely unknown. We found that pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 14,15-EET significantly increased the field excitatory postsynaptic potential (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and forskolin- (FSK-) induced LTP...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29135231/solid-semi-solid-and-liquid-phase-states-of-individual-submicrometer-particles-directly-probed-using-atomic-force-microscopy
#3
Hansol D Lee, Kamal K Ray, Alexei V Tivanski
Currently, the impact of various phase states of aerosols on the climate is not well understood, especially for submicrometer sized aerosol particles that typically have extended life time in the atmosphere. This is largely due to the inherent size-limitations present in current experimental techniques that aim to directly assess the phase states of fine aerosol particles. Here-in we present a technique that uses atomic force microscopy (AFM) to directly probe for the phase states of individual, submicrometer particles by using nanoindentation and nano-Wilhelmy methodologies as a function of relative humidity (RH) and ambient temperature conditions...
November 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29130578/sirt3-deregulation-is-linked-to-mitochondrial-dysfunction-in-alzheimer-s-disease
#4
Junghee Lee, Yunha Kim, Tian Liu, Yu Jin Hwang, Seung Jae Hyeon, Hyeonjoo Im, Kyungeun Lee, Victor E Alvarez, Ann C McKee, Soo-Jong Um, Manwook Hur, Inhee Mook-Jung, Neil W Kowall, Hoon Ryu
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between mitochondrial pathology and neuronal damage is poorly understood. Sirtuins (SIRT, silent mating type information regulation 2 homolog in yeast) are NAD-dependent histone deacetylases involved in aging and longevity. The objective of this study was to investigate the relationship between SIRT3 and mitochondrial function and neuronal activity in AD...
November 11, 2017: Aging Cell
https://www.readbyqxmd.com/read/29126106/airvf-a-filtering-toolbox-for-precise-variant-calling-in-ion-torrent-sequencing
#5
Sunguk Shin, Hanna Lee, Hyeonju Son, Soonmyung Paik, Sangwoo Kim
Summary: Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and industry. Despite many advantages, platform-specific artifacts complicate efficient separation of true variants from errors, especially in variants with lower allele frequencies (<15%). Here, we developed a multi-step filtering toolbox AIRVF that works on flowgram, raw and mapped reads and called variants to reduce artifact-driven false variant calls. Tests on sequencing data of standard reference material showed up to ∼98% reduction of false variants when combined to conventional public pipelines and ∼48% to the in-house commercial solution, with a minimal loss of sensitivity...
November 6, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29124092/dataset-of-the-livability-performance-of-the-city-of-birmingham-uk-as-measured-by-its-citizen-wellbeing-resource-security-resource-efficiency-and-carbon-emissions
#6
Joanne M Leach, Susan E Lee, Christopher T Boyko, Claire J Coulton, Rachel Cooper, Nicholas Smith, Hélène Joffe, Milena Büchs, James D Hale, Jonathan P Sadler, Peter A Braithwaite, Luke S Blunden, Valeria De Laurentiis, Dexter V L Hunt, AbuBakr S Bahaj, Katie Barnes, Christopher J Bouch, Leonidas Bourikas, Marianna Cavada, Andrew Chilvers, Stephen J Clune, Brian Collins, Ellie Cosgrave, Nick Dunn, Jane Falkingham, Patrick James, Corina Kwami, Martin Locret-Collet, Francesca Medda, Adriana Ortegon, Serena Pollastri, Cosmin Popan, Katerina Psarikidou, Nick Tyler, John Urry, Yue Wu, Victoria Zeeb, Chris D F Rogers
This data article presents the UK City LIFE1 data set for the city of Birmingham, UK. UK City LIFE1 is a new, comprehensive and holistic method for measuring the livable sustainability performance of UK cities. The Birmingham data set comprises 346 indicators structured simultaneously (1) within a four-tier, outcome-based framework in order to aid in their interpretation (e.g., promote healthy living and healthy long lives, minimize energy use, uncouple economic vitality from CO2 emissions) and (2) thematically in order to complement government and disciplinary siloes (e...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29112716/gene3d-extensive-prediction-of-globular-domains-in-proteins
#7
Tony Lewis, Ian Sillitoe, Natalie Dawson, Su Datt Lam, Tristan Clarke, David Lee, Christine Orengo, Jonathan Lees
Gene3D (http://gene3d.biochem.ucl.ac.uk) is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains...
November 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29095980/pedigreejs-a-web-based-graphical-pedigree-editor
#8
Tim Carver, Alex P Cunningham, Chantal Babb de Villiers, Andrew Lee, Simon Hartley, Marc Tischkowitz, Fiona M Walter, Douglas F Easton, Antonis C Antoniou
Motivation: The collection, management and visualisation of clinical pedigree (family history) data is a core activity in clinical genetics centres. However, clinical pedigree datasets can be difficult to manage, as they are time consuming to capture, and can be difficult to build, manipulate and visualise graphically. Several standalone graphical pedigree editors and drawing applications exist but there are no freely available lightweight graphical pedigree editors that can be easily configured and incorporated into web applications...
October 31, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29095318/percutaneous-transhepatic-gallbladder-drainage-followed-by-elective-laparoscopic-cholecystectomy-for-patients-with-moderate-to-severe-acute-cholecystitis
#9
Ryukyung Lee, Heontak Ha, Young Seok Han, Hyung Jun Kwon, Hunkyu Ryeom, Jae Min Chun
Percutaneous transhepatic gallbladder drainage followed by laparoscopic cholecystectomy (PTGBD+LC) is one treatment option for patients with moderate to severe acute cholecystitis (AC). However, the impact of PTGBD on operative difficulties in performing LC is controversial. We designed this retrospective study to clarify the surgical outcomes after PTGBD+LC for the management of patients with moderate to severe AC.The medical records of 85 patients who underwent LC for moderate to severe AC from January 2013 to September 2016 were evaluated...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29091979/helping-seniors-plan-for-posthospital-discharge-needs-before-a-hospitalization-occurs-results-from-the-randomized-control-trial-of-planyourlifespan-org
#10
Lee A Lindquist, Vanessa Ramirez-Zohfeld, Priya D Sunkara, Chris Forcucci, Dianne S Campbell, Phyllis Mitzen, Jody D Ciolino, Gayle Kricke, Anne Seltzer, Ana V Ramirez, Kenzie A Cameron
OBJECTIVE: Investigate the effect of PlanYourLifespan.org (PYL) on knowledge of posthospital discharge options. DESIGN: Multisite randomized controlled trial. SETTING/PATIENTS: Nonhospitalized adults, aged =65 years, living in urban, suburban, and rural areas of Texas, Illinois, and Indiana. INTERVENTION: PYL is a national, publicly available tool that provides education on posthospital therapy choices and local home-based resources...
November 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29066807/effects-of-recovery-time-during-magnetic-nanofluid-hyperthermia-on-the-induction-behavior-and-efficiency-of-heat-shock-proteins-72
#11
Jung-Tak Jang, Jin Wook Jeoung, Joo Hyun Park, Won June Lee, Yu Jeong Kim, Jiyun Seon, Minkyu Kim, Jooyoung Lee, Sun Ha Paek, Ki Ho Park, Seongtae Bae
In this study, we investigated the effects of recovery time during magnetic nanofluid hyperthermia (MNFH) on the cell death rate and the heat shock proteins 72 (HSP72) induction behavior in retinal ganglion cells (RGCs-5) to provide a possible solution for highly efficient ocular neuroprotection. The recovery time and the heat duration time during MNFH were systematically controlled by changing the duty cycle of alternating current (AC) magnetic field during MNFH. It was clearly observed that the cell death rate and the HSP72 induction rate had a strong dependence on the recovery time and the optimizated recovery time resulted in maximizing the induction efficiency of HSP72...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057683/second-trimester-growth-velocities-assessment-of-fetal-growth-potential-in-sga-singletons
#12
Russell L Deter, Wesley Lee, John Kingdom, Roberto Romero
OBJECTIVE: To evaluate the validity of second trimester growth velocities as measures of fetal growth potential in SGA singletons. METHODS: Second trimester growth velocities for BPD, HC, AC and FDL were determined by linear regression analysis in 53 SGA singletons with normal growth outcomes [SGA N Group] and 73 with growth restriction [SGA GR] based on a composite Fetal Growth Pathology Score [FGPS1]. The latter were subdivided into six groups based on their growth restriction pattern [Patterns Group]...
October 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29028887/identification-of-cancer-driver-genes-in-focal-genomic-aberrations-from-whole-exome-sequencing-data
#13
Ho Jang, Hyunju Lee
Summary: Whole-exome sequencing (WES) data have been used for identifying copy number aberrations in cancer cells. Nonetheless, the use of WES is still challenging for identification of focal aberrant regions in multiple samples that may contain cancer driver genes. In this study, we developed a wavelet-based method for identifying focal genomic aberrant regions in the WES data from cancer cells (WIFA-X). When we applied WIFA-X to glioblastoma multiforme and lung adenocarcinoma datasets, WIFA-X outperformed other approaches on identifying cancer driver genes...
September 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027097/high-number-of-newly-initiated-direct-oral-anticoagulant-users-switch-to-alternate-anticoagulant-therapy
#14
Beenish S Manzoor, Surrey M Walton, Lisa K Sharp, William L Galanter, Todd A Lee, Edith A Nutescu
Real-world evidence focusing on medication switching patterns amongst direct oral anticoagulant (DOACs) has not been well studied. The objective of this study is to evaluate patterns of prescription switching in non-valvular atrial fibrillation (NVAF) patients initiated on a DOAC and previously naïve to anticoagulation (AC) therapy. Data was obtained from Truven Health MarketScan(®) Commercial and Medicare Supplemental database (2009-2013). AC naïve (those without prior anticoagulant use) NVAF patients initiated on a DOAC, with 6 months of continuous health plan enrollment before and after treatment initiation and maintained on continuous therapy for a minimum of 6 months were included...
November 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29019239/enhanced-dc-operated-electroluminescence-of-forwardly-aligned-%C3%A2-%C3%A2-p-mqw-n-ingan-nanorod-leds-via-dc-offset-ac-dielectrophoresis
#15
Yun Jae Eo, Gang Yeol Yoo, Hyelim Kang, Young Ki Lee, Chan Sik Kim, Ji Hye Oh, Keyong Nam Lee, Woong Kim, Young Rag Do
We introduce an orientation-controlled alignment process of p-GaN/InGaN multiquantum-well/n-GaN (p/MQW/n InGaN) nanorod light-emitting diodes (LEDs) by applying the direct current (DC) offset-alternating current (AC) or pulsed DC electric fields across interdigitated metal electrodes. The as-forwardly aligned p/MQW/n InGaN nanorod LEDs by a pulsed DC dielectrophoresis (DEP) assembly process improve the electroluminescence (EL) intensities by 1.8 times compared to the conventional AC DEP assembly process under DC electric field operation and exhibit an enhanced applied current and EL brightness in the current-voltage and EL intensity-voltage curves, which can be directly used as the fundamental data to construct DC-operated nanorod LED devices, such as LED areal surface lightings, scalable lightings (micrometers to inches) and formable surface lightings...
October 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28990589/which-anthropometric-measures-best-reflect-neonatal-adiposity
#16
L-W Chen, M-T Tint, M V Fortier, I M Aris, Lp-C Shek, K H Tan, S-Y Chan, P D Gluckman, Y-S Chong, K M Godfrey, V S Rajadurai, F Yap, M S Kramer, Y S Lee
BACKGROUND: Studying the determinants and the long-term consequences of fetal adipose accretion requires accurate assessment of neonatal body composition. In large epidemiological studies, in-depth body composition measurement methods are usually not feasible for cost and logistical reasons, and there is a need to identify anthropometric measures that adequately reflect neonatal adiposity. METHODS: In a multiethnic Asian mother-offspring cohort in Singapore, anthropometric measures (weight, length, abdominal circumference, skinfold thicknesses) were measured using standardized protocols in newborn infants, and anthropometric indices [weight/length, weight/length(2) (body mass index, BMI), weight/length(3) (ponderal index, PI)] derived...
October 9, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28985054/efficient-suppression-of-defects-and-charge-trapping-in-high-density-in-sn-zn-o-thin-film-transistor-prepared-using-microwave-assisted-sputter
#17
Youngin Goh, Jaehan Ahn, Jeong Rak Lee, Wan Woo Park, Sang-Hee Ko Park, Sanghun Jeon
Amorphous oxide semiconductor-based thin film transistors (TFTs) have been considered as excellent switching elements for driving active-matrix organic light-emitting diodes (AMOLED) owing to their high mobility and process compatibility. However, oxide semiconductors have inherent defects, causing fast transient charge trapping and device instability. For the next-generation displays such as flexible, wearable, or transparent displays, an active semiconductor layer with ultrahigh mobility and high reliability at low deposition temperature is required...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932434/crystal-structure-of-2-3-diphenyl-2-3-di-hydro-4h-1-3-benzo-thia-zin-4-one-1-oxide
#18
Hemant P Yennawar, Ryan Fox, Quentin J Moyer, Ziwei Yang, Lee J Silverberg
In the racemic title compound, C20H15NO2S, the planes of the two phenyl substituents form dihedral angles of 48.97 (15) and 69.26 (15)° with that of the fused benzene ring of the parent benzo-thia-zine ring, while the heterocyclic thia-zine ring exhibits a screw-boat pucker. The O atom on the S atom of the ring is pseudo-axial on the thia-zine ring and trans to the 2-phenyl group. In the crystal, mol-ecules are arranged in layers in the ac plane, the layers being linked across b through inter-molecular C-H⋯O hydrogen-bonding inter-actions...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28916954/discrimination-and-mental-health-in-a-representative-sample-of-african-american-and-afro-caribbean-youth
#19
Lee M Pachter, Cleopatra H Caldwell, James S Jackson, Bruce A Bernstein
BACKGROUND: Racism and discrimination are psychosocial stressors that affect the health of minority populations. While discrimination has been associated with poor mental health, little is known about the relationship between discrimination and mental health outcomes in youth nationally. Furthermore, mental and behavioral health consequences of discrimination may differ in different minority groups. OBJECTIVE: The goal of this study is to determine (1) how common perceptions of discrimination are in a nationally representative sample of African-American (AA) and Afro-Caribbean (AC) teens, (2) the relationship between discrimination and mental health conditions, and (3) whether discrimination has different associations with mental health in AA and AC youth...
September 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28902884/development-of-est-ssr-markers-in-flowering-chinese-cabbage-brassica-campestris-l-ssp-chinensis-var-utilis-tsen-et-lee-based-on-de-novo-transcriptomic-assemblies
#20
Jingfang Chen, Ronghua Li, Yanshi Xia, Guihua Bai, Peiguo Guo, Zhiliang Wang, Hua Zhang, Kadambot H M Siddique
Flowering Chinese cabbage is one of the most important vegetable crops in southern China. Genetic improvement of various agronomic traits in this crop is underway to meet high market demand in the region, but the progress is hampered by limited number of molecular markers available in this crop. This study aimed to develop EST-SSR markers from transcriptome sequences generated by next-generation sequencing. RNA-seq of eight cabbage samples identified 48,975 unigenes. Of these unigenes, 23,267 were annotated in 56 gene ontology (GO) categories, 6,033 were mapped to 131 KEGG pathways, and 7,825 were assigned to clusters of orthologous groups (COGs)...
2017: PloS One
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