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Chia-Chun Hsu, Yan-Chang Lee, Wen-Hsin Hsieh
This study uses negative dielectrophoresis and AC electroosmosis as a driving mechanism and presents an electrically driven microconcentrator that concentrates the sample in the region exterior to the electrodes (termed as exterior-electrode electrically driven microconcentrator in this paper). The proposed microconcentrator uses a 3-D face-to-face electrode pair; the top electrode is a relatively large planar electrode, and the bottom electrode is formed with three to six long and thin electrodes connected into an open ring...
July 13, 2018: Electrophoresis
Ji Yeon Lee, Yoon Jeong Choi, Seong-Ho Choi, Chooryung J Chung, Hyung-Seog Yu, Kyung-Ho Kim
BACKGROUND: Labially impacted maxillary canines may lack periodontal tissue after orthodontic traction. This study evaluated the periodontal status of labially impacted maxillary canines after the closed eruption technique followed by orthodontic traction and investigated pretreatment variables affecting periodontal changes. METHODS: Patients with one labially impacted maxillary canine (impaction group) and one contralateral normal canine (control group) were selected retrospectively...
July 12, 2018: Journal of Periodontology
Jaeseong Jang, Yejin Park, Bukweon Kim, Sung Min Lee, Ja-Young Kwon, Jin Keun Seo
Ultrasound diagnosis is routinely used in obstetrics and gynecology for fetal biometry, and owing to its time-consuming process, there has been a great demand for automatic estimation. However, the automated analysis of ultrasound images is complicated because they are patient-specific, operator-dependent, and machine-specific. Among various types of fetal biometry, the accurate estimation of abdominal circumference (AC) is especially difficult to perform automatically because the abdomen has low contrast against surroundings, non-uniform contrast, and irregular shape compared to other parameters...
November 21, 2017: IEEE Journal of Biomedical and Health Informatics
Wook Lee, Byungkyu Park, Kyungsook Han
A transcription factor (TF) is a protein that regulates gene expression by binding to specific DNA sequences. Despite the recent advances in experimental techniques for identifying transcription factor binding sites (TFBS) in DNA sequences, a large number of TFBS are to be unveiled in many species. Several computational methods developed for predicting TFBS in DNA are tissue- or species-specific methods, so cannot be used without prior knowledge of tissue or species. Some computational methods are applicable to finding TFBS in short DNA sequences only...
November 14, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Cong Wang, Keon Ah Lee, Eunpyo Choi, Keun-Young Lee, Seung-Yop Lee, Kwang-Hwan Jung, Jungyul Park
In this study, a new strategy for improving the radionuclide bio-decontamination (RBD) activity of microalgae by screening a better strain with high potential for biomineral production has been proposed. A noninvasive dielectrophoresis (DEP)-based microalgae screening microplatform has been used to select the highly capable microalgae in RBD. Microalgae (Chlorella vulgaris KMMCC9) with a high degree of competence in strontium (Sr) removal were successfully segregated against Chlorella vulgaris KCTC AG10002 that has relatively weak Sr removal activity under an AC electric field...
July 6, 2018: Lab on a Chip
Moonjeong Bok, Yunwoo Lee, Daehoon Park, Sangho Shin, Zhi-Jun Zhao, Boyeon Hwang, Soon Hyoung Hwang, So Hee Jeon, Joo-Yun Jung, Sung Ha Park, Junghyo Nah, Eunju Lim, Jun-Ho Jeong
In this study, a combined system of microneedles and a triboelectric nanogenerator (TENG) has been developed for drug delivery. A triboelectric device, which converts mechanical energy into alternating current (AC), was chosen to replace the electrophoresis (EP) effect. To directly generate triboelectricity from salmon deoxyribonucleic acid (SDNA)-based microneedles, a triboelectric series of SDNA film and chargeable polymers (polyimide and Teflon) was studied. The electrical output of the two charged polymers was compared to find a material that could be highly charged with SDNA...
July 4, 2018: Nanoscale
Anoop S V Shah, Dominik Stelzle, Kuan Ken Lee, Eduard J Beck, Shirjel Alam, Sarah Clifford, Chris T Longenecker, Fiona E Strachan, Shashwatee Bagchi, William Whiteley, Sanjay Rajagopalan, Shyamasundaran Kottilil, Harish Nair, David E Newby, David A McAllister, Nicholas L Mills
Background -With advances in anti-retroviral therapy, most deaths in people with human immune-deficiency virus (HIV) are now due to non-communicable illnesses especially cardiovascular disease. We determine the association between HIV and cardiovascular disease, and estimate the national, regional and global burden of cardiovascular disease attributable to HIV. Methods -We conducted a systematic review across five databases from inception to August 2016 for longitudinal studies of cardiovascular disease in HIV infection...
July 2, 2018: Circulation
Jinxing Zhao, Chang Liu, Kun Xiang, Qi Cheng, Yuxiao Li, Huan Lin, Kuan-Ting Lee, Liang An, Shun Tang, Yuan-Cheng Cao, Jiyuan Liang
Nitrogen doped carbon nanocage with graphitic shell (NGCS) was fabricated through in-situ solid reaction between calcium acetate and dicyandiamide in an inert atmosphere followed by acid etching. The role played by the calcium acetate (Ca(Ac)2) and dicyandiamide (DCD) during the synthesis process is one-stone-two-birds. Calcium acetate plays multiple functions: template agent, graphitization catalyst, and carbon source. Dicyandiamide can be considered as the nitrogen sources and the chemical reaction agent that can be reacted with calcium acetate to form it into CaCN2...
October 1, 2018: Journal of Nanoscience and Nanotechnology
Dinesh Kumar, C N Kuo, F Astuti, Tian Shang, Min-Kai Lee, C S Lue, Isao Watanabe, J A T Barker, Toni Shiroka, L J Chang
We report the single-crystal synthesis and detailed investigations of the cage-type superconductor Sc5Ru6Sn18, using powder x-ray diffraction (XRD), magnetization, specific-heat and muon-spin relaxation (μSR) measurements. Sc5Ru6Sn18 crystallizes in a tetragonal structure (space group I41/acd) with the lattice parameters a = 1.387(3) nm, c = 2.641(5) nm. Both DC and AC magnetization measurements prove the type-II superconductivity in Sc5Ru6Sn18 with T_c ≈ 3.5(1) K, a lower critical field H_c1 (0) = 157(9) Oe and an upper critical field, H_c2 (0) = 26(1) kOe...
June 27, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Dongyoul Lee, Mengshi Li, Bryan Bednarz, Michael K Schultz
The use of targeted radionuclide therapy for cancer is on the rise. While beta-particle-emitting radionuclides have been extensively explored for targeted radionuclide therapy, alpha-particle-emitting radionuclides are emerging as effective alternatives. In this context, fundamental understanding of the interactions and dosimetry of these emitted particles with cells in the tumor microenvironment is critical to ascertaining the potential of alpha-particle-emitting radionuclides. One important parameter that can be used to assess these metrics is the S-value...
June 26, 2018: Radiation Research
Hye Lim Lee, Sung Chul Hwang, Jae Woon Nah, Jungsoo Kim, Byungyoul Cha, Dae Hwan Kang, Young-Il Jeong
Redox-responsive nanoparticles having a diselenide linkage were synthesized to target pulmonary metastasis of cancer cells. Methoxy poly(ethylene glycol)-grafted chitosan (ChitoPEG) was crosslinked using selenocystine-acetyl histidine (Ac-histidine) conjugates (ChitoPEGse) for stimuli-responsive delivery of piperlongumine (PL). ChitoPEGse nanoparticles swelled in an acidic environment and became partially disintegrated in the presence of H2 O2 , resulting in an increase of particle size and in a size distribution having multimodal pattern...
June 21, 2018: Journal of Pharmaceutical Sciences
Wooram Lee, Sangwon Yoon, Jong Kwon Choe, Miran Lee, Yongju Choi
This study investigates the effect of anionic surfactant modification on activated carbon (AC) to enhance the adsorption of ammonium ion in aqueous solution. Sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS) or sodium octanoate (SO) was used for the modification. At the initial aqueous concentration of 55 mg NH4 -N/L and the adsorbent dose of 50 g/L, the SDS-modified AC showed the highest ammonium removal efficiency of 82% among the modified ACs studied. The hydrophobic group of SDS was strongly attached to AC showing almost negligible desorption after the modification...
October 15, 2018: Science of the Total Environment
Ji-Hyun Lee, Seungman Yang, Jonghyun Park, Hee Chan Kim, Eun-Hee Kim, Young-Eun Jang, Jin-Tae Kim, Hee-Soo Kim
BACKGROUND: Respiratory variations in photoplethysmography amplitude enable volume status assessment. However, the contact force between the measurement site and sensor can affect photoplethysmography waveforms. We aimed to evaluate contact force effects on respiratory variations in photoplethysmography waveforms in children under general anesthesia. METHODS: Children aged 3-5 years were enrolled. After anesthetic induction, mechanical ventilation commenced at a tidal volume of 10 mL/kg...
June 19, 2018: Paediatric Anaesthesia
Shou-Wu Lee, Han-Chung Lien, Chi-Chen Lin, Mei-Chin Wen, Chi-Sen Chang
Background: The aim of this study was to investigate the expression of transforming growth factor β (TGF-β) in the different stages of Barrett's esophagus (BE). Methods: Paired endoscopic esophageal biopsy samples were obtained from patients with BE prospectively. Subjects were classified into three groups: BE, BE with dysplasia, and adenocarcinoma (AC) arising from BE. Biopsy specimens over normal esophageal epithelium and gastric cardiac epithelium of limited cases were done...
June 2018: Gastroenterology Research
Peter J Kneuertz, Mohamed K Kamel, Brendon M Stiles, Benjamin E Lee, Mohamed Rahouma, Sebron W Harrison, Nasser K Altorki, Jeffery L Port
BACKGROUND: Pulmonary carcinoid tumors are often considered indolent tumors. The prognostic significance of lymph node (LN) metastases and the need for mediastinal dissection is controversial. We sought to determine the incidence, risk factors, and prognosis of LN metastases in resected carcinoid patients. METHODS: Patients undergoing lung resection for carcinoid and removal of ≥10 LNs were identified in the National Cancer Database form 2004-2014. Typical (TC) and atypical (AC) carcinoids were included...
June 14, 2018: Annals of Thoracic Surgery
Se Won Kang, Bharat Bhusan Patnaik, So Young Park, Hee-Ju Hwang, Jong Min Chung, Min Kyu Sang, Hye Rin Min, Jie Eun Park, Jiyeon Seong, Yong Hun Jo, Mi Young Noh, Jong Dae Lee, Ki Yoon Jung, Hong Seog Park, Yeon Soo Han, Jun Sang Lee, Yong Seok Lee
Ellobium chinense (Pfeiffer, 1854) is a brackish pulmonate species that inhabits the bases of mangrove trees and is most commonly found in salt grass meadows. Threats to mangrove ecosystems due to habitat degradation and overexploitation have threatened the species with extinction. In South Korea, E. chinense has been assessed as vulnerable, but there are limited data on its population structure and distribution. The nucleotide and protein sequences for this species are not available in databases, which limits the understanding of adaptation-related traits...
April 2018: Genes & Genomics
He Wen, Sujin Lee, Wei-Guo Zhu, Ok-Jun Lee, Seok Joong Yun, Jayoung Kim, Sunghyouk Park
Cisplatin is an important chemotherapeutic agent against metastatic bladder cancer, but resistance often limits its usage. With the recent recognition of lipid metabolic alterations in bladder cancers, we studied the metabolic implications of cisplatin resistance using cisplatin-sensitive (T24S) and resistant (T24R) bladder cancer cells. Real-time live metabolomics revealed that T24R cells consume more glucose, leading to higher production of glucose-derived acetate and fatty acids. Along with the activation of general metabolic regulators, enzymes involved in acetate usage (ACSS2) and fatty acid synthesis (ACC) and a precursor for fatty acid synthesis (acetyl-CoA) were elevated in T24R cells...
June 5, 2018: Biochimica et Biophysica Acta
Yu Ran Lee, Myoung Soo Park, Hee Kyoung Joo, Ki Mo Kim, Jeryong Kim, Byeong Hwa Jeon, Sunga Choi
Triple-negative breast cancer (TNBC) represents a relatively small proportion of all BCs but a relatively large proportion of BC-related death. Thus, more effective therapeutic strategies are needed for the management of TNBC. We demonstrated that the stimulation of apoptosis by the binding of secreted acetylated-apurinic apyrimidinic endonuclease 1/redox factor-1 (Ac-APE1/Ref-1) to the receptor for advanced glycation end products (RAGE) was essential for TNBC cell death in response to hyperacetylation. The aim of the present study was to assess the potential therapeutic efficacy of secretory Ac-APE1/Ref-1 in orthotopic TNBC xenografts in vivo...
June 7, 2018: Scientific Reports
Junghwan Baek, Byunghan Lee, Sunyoung Kwon, Sungroh Yoon
Motivation: Long non-coding RNAs (lncRNAs) are important regulatory elements in biological processes. LncRNAs share similar sequence characteristics with messenger RNAs (mRNAs), but they play completely different roles, thus providing novel insights for biological studies. The development of next-generation sequencing (NGS) has helped in the discovery of lncRNA transcripts. However, the experimental verification of numerous transcriptomes is time consuming and costly. To alleviate these issues, a computational approach is needed to distinguish lncRNAs from the transcriptomes...
May 29, 2018: Bioinformatics
Kyoung-Ryul Lee, Sung Hwan Jang, Inhwa Jung
We investigated the acoustic performance of electrostatic sound-generating devices consisting of bi-layer graphene on polyimide film. The total sound pressure level (SPL) of the sound generated from the devices was measured as a function of source frequency by sweeping, and frequency spectra were measured at 1/3 octave band frequencies. The relationship between various operation conditions and total SPL was determined. In addition, the effects of changing voltage level, adding a DC offset, and using two pairs of electrodes were evaluated...
August 10, 2018: Nanotechnology
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