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https://www.readbyqxmd.com/read/29786618/acoustic-performance-of-dual-electrode-electrostatic-sound-generators-based-on-cvd-graphene-on-polyimide-film
#1
Kyoung-Ryul Lee, Sung Hwan Jang, Inhwa Jung
We investigated the acoustic performance of electrostatic sound-generating devices consisting of bilayer graphene on polyimide (PI) film. Total sound pressure level (SPL) of sound generated from the devices was measured as a function of source frequency by sweeping, and frequency spectra were measured at 1/3 octave band frequencies. The relationship between various operation conditions and total SPL was determined. In addition, the effects of changing voltage level, adding a DC offset, and using two pairs of electrodes were evaluated...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29784903/exercise-ameliorates-endoplasmic-reticulum-stress-mediated-vascular-dysfunction-in-mesenteric-arteries-in-atherosclerosis
#2
Junyoung Hong, Kwangchan Kim, Eunkyung Park, Jonghae Lee, Melissa M Markofski, Sean P Marrelli, Yoonjung Park
Endoplasmic reticulum (ER) stress is closely associated with atherosclerosis, but the effects of exercise on ER stress-mediated endothelial dysfunction in atherosclerosis is not yet fully understood. We assessed endothelium-dependent vasodilation in isolated mesenteric arteries from wild type (WT), WT with exercise (WT-EX), ApoE knockout (ApoE KO), and ApoE KO mice with exercise (ApoE KO-EX). Vasodilation to acetylcholine (ACh) was elicited in the presence of inhibitors of ER stress, eNOS, caspase-1, and UCP-2 (Tudca, L-NAME, AC-YVARD-cmk, and Genipin, respectively) and the ER stress inducer (Tunicamycin)...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774827/remediation-of-metal-contaminated-marine-sediments-using-active-capping-with-limestone-steel-slag-and-activated-carbon-a-laboratory-experiment
#3
Seong-Jik Park, Ku Kang, Chang-Gu Lee, Jae-Woo Choi
The objectives of this study are to assess the effectiveness of limestone (LS), steel slag (SS), and activated carbon (AC) as capping materials to sequester trace metals including As, Cd, Cr, Cu, Ni, Pb, and Zn in heavily contaminated marine sediments and to minimize the release of these metals into the water column. A flat flow tank was filled with 10 mm of capping material, contaminated sediments, and seawater, and the metal concentrations were monitored over 32 d. After completion of the flow tank experiments, the sediments below the capping material were sampled and were sequentially extracted...
May 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29771118/escherichia-coli-fiber-sensors-using-concentrated-dielectrophoretic-force-with-optical-defocusing-method
#4
Yi-Hsin Tai, Chia-Wei Lee, Dao-Ming Chang, Yu-Sheng Lai, Ding-Wei Huang, Pei-Kuen Wei
A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used to rapid and label-free detection of bacteria in water. The angular spectrum of optical field at the fiber tip was changed with surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95,200 %/RIU (RI unit) and the detection limit was 2.1 × 10-6 RIU at 0.2% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli (E...
May 17, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29770631/comparison-between-adjuvant-chemotherapy-and-adjuvant-radiotherapy-chemoradiotherapy-after-radical-surgery-in-patients-with-cervical-cancer-a-meta-analysis
#5
Kwang Beom Lee, Seung Hyuk Shim, Jong Min Lee
OBJECTIVE: To estimate the effect of adjuvant chemotherapy (AC) on the prognosis in cervical cancer patients with intermediate- or high-risk factors after radical hysterectomy (RH) compared to that for adjuvant radiotherapy (AR). METHODS: The Embase and MEDLINE databases and the Cochrane Library were searched for published studies comparing cervical cancer patients who received AC with those who received AR after RH. The endpoints were patient oncologic outcome...
April 16, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29768496/the-effect-of-adjuvant-chemotherapy-on-survival-in-korean-patients-with-node-negative-t1c-triple-negative-breast-cancer
#6
Seung Taek Lim, Chan Heun Park, Sung Yong Kim, Seok Jin Nam, Eun Young Kang, Byung-In Moon, Hyouk Jin Lee, Ye Won Jeon, Hongki Gwak, Young Jin Suh
BACKGROUND: The present study investigated the prognostic role of adjuvant systemic chemotherapy in patients with node negative, T1c triple negative breast cancer (TNBC) from a nationwide cohort. In addition, the prognostic effect between 3 different chemotherapy regimens were compared in node-negative T1c TNBC patients by subgroup analysis. METHODS: From the Korean breast cancer registry database, 1,151 T1c node negative TNBC patients were included in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29767964/a-synthetic-polymer-affinity-ligand-for-bacillus-thuringiensis-bt-cry1ab-ac-protein-the-use-of-biomimicry-based-on-the-bt-protein-insect-receptor-binding-mechanism
#7
Mingming Liu, Rong Huang, Adam C Weisman, Xiaoyang Yu, Shih-Hui Lee, Yalu Chen, Chao Huang, Senhua Hu, Xiuhua Chen, Wenfeng Tan, Fan Liu, Hao Chen, Kenneth J Shea
We report a novel strategy for creating abiotic Bacillus thuringiensis (Bt) protein affinity ligands by biomimicry of the recognition process that takes place between Bt Cry1Ab/Ac proteins and insect receptor cadherin-like Bt-R1 proteins. Guided by this strategy, a library of synthetic polymer nanoparticles (NPs) was prepared and screened for binding to three epitopes 280FRGSAQGIEGS290, 368RRPFNIGINNQQ379 and 436FRSGFSNSSVSIIR449 located in loop α8, loop 2 and loop 3 of domain II of Bt Cry1Ab/Ac proteins. A negatively charged and hydrophilic nanoparticle (NP12) was found to have high affinity to one of the epitopes, 368RRPFNIGINNQQ379...
May 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29765724/crystal-structures-of-two-2-3-diaryl-2-3-di-hydro-4-h-1-3-benzo-thia-zin-4-ones
#8
Hemant P Yennawar, Michaela J Buchwalter, Baylee K Colburn, Lee J Silverberg
The syntheses and crystal structures of 2,3-bis-[3-(tri-fluoro-meth-yl)phen-yl]-2,3-di-hydro-4 H -1,3-benzo-thia-zin-4-one (di- m -CF3 ; C22 H13 F6 NOS) ( 1 ) and 2,3-bis-(4-methyl-phen-yl)-2,3-di-hydro-4 H -1,3-benzo-thia-zin-4-one (di- p -CH3 ; C22 H19 NOS) ( 2 ) are reported. Each structure is racemic: the asymmetric unit of 2 consists of two mol-ecules. In both 1 and 2 , the six-membered 1,3-thia-zine ring is close to an envelope conformation with the chiral C atom forming the flap. In 1 , the 2-aryl group is pseudo-equatorial, while in 2 it is pseudo-axial...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29764530/influence-of-maternal-adiposity-preterm-birth-and-birth-weight-centiles-on-early-childhood-obesity-in-an-indigenous-australian-pregnancy-through-to-early-childhood-cohort-study
#9
K G Pringle, Y Q Lee, L Weatherall, L Keogh, C Diehm, C T Roberts, S Eades, A Brown, R Smith, E R Lumbers, L J Brown, C E Collins, K M Rae
Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Related-Optimal Weight (GROW) centiles, maternal adiposity (percentage body fat, visceral fat area), maternal non-fasting plasma glucose levels (measured at mean gestational age of 23...
May 16, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29758273/in-silico-experiment-system-for-testing-hypothesis-on-gene-functions-using-three-condition-specific-biological-networks
#10
Chai-Jin Lee, Dongwon Kang, Sangseon Lee, Sunwon Lee, Jaewoo Kang, Sun Kim
Determining functions of a gene requires time consuming, expensive biological experiments. Scientists can speed up this experimental process if the literature information and biological networks can be adequately provided. In this paper, we present a web-based information system that can perform in silico experiments of computationally testing hypothesis on the function of a gene. A hypothesis that is specified in English by the user is converted to genes using a literature and knowledge mining system called BEST...
May 11, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29756844/%C3%AF-and-4%C3%AF-josephson-effects-mediated-by-a-dirac-semimetal
#11
W Yu, W Pan, D L Medlin, M A Rodriguez, S R Lee, Zhi-Qiang Bao, F Zhang
Cd_{3}As_{2} is a three-dimensional topological Dirac semimetal with connected Fermi-arc surface states. It has been suggested that topological superconductivity can be achieved in the nontrivial surface states of topological materials by utilizing the superconductor proximity effect. Here we report observations of both π and 4π periodic supercurrents in aluminum-Cd_{3}As_{2}-aluminum Josephson junctions. The π period is manifested by both the magnetic-field dependence of the critical supercurrent and the appearance of half-integer Shapiro steps in the ac Josephson effect...
April 27, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29747787/preferred-exercise-modalities-in-patients-with-intermittent-claudication
#12
Amy Elizabeth Harwood, Louise Helen Hitchman, Lee Ingle, Patrick Doherty, Ian Clifford Chetter
Conventional supervised exercise programs (SEPs) for claudicants are traditionally based on time-constrained, group-based structured programs usually at a hospital site. Uptake of an SEP is poor, despite the high-level evidence demonstrating its clinical effectiveness; therefore, alternative forms of exercise programs are needed which are more acceptable to patients. This study aimed to explore a range of exercise modalities to determine patient preferences for exercise delivery on a national level. This was a questionnaire survey to identify and incorporate patient preferences when designing a multicenter nationwide health-service evaluation of patient preference to exercise in the United Kingdom's National Health Service (the PREFER study)...
June 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29746660/interspia-a-web-application-for-exploring-the-dynamics-of-protein-protein-interactions-among-multiple-species
#13
Daehong Kwon, Daehwan Lee, Juyeon Kim, Jongin Lee, Mikang Sim, Jaebum Kim
Proteins perform biological functions through cascading interactions with each other by forming protein complexes. As a result, interactions among proteins, called protein-protein interactions (PPIs) are not completely free from selection constraint during evolution. Therefore, the identification and analysis of PPI changes during evolution can give us new insight into the evolution of functions. Although many algorithms, databases and websites have been developed to help the study of PPIs, most of them are limited to visualize the structure and features of PPIs in a chosen single species with limited functions in the visualization perspective...
May 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29743507/re-exploration-of-u-s-triangle-brassica-species-based-on-chloroplast-genomes-and-45s-nrdna-sequences
#14
Chang-Kug Kim, Young-Joo Seol, Sampath Perumal, Jonghoon Lee, Nomar Espinosa Waminal, Murukarthick Jayakodi, Sang-Choon Lee, Seungwoo Jin, Beom-Soon Choi, Yeisoo Yu, Ho-Cheol Ko, Ji-Weon Choi, Kyoung-Yul Ryu, Seong-Han Sohn, Isobel Parkin, Tae-Jin Yang
The concept of U's triangle, which revealed the importance of polyploidization in plant genome evolution, described natural allopolyploidization events in Brassica using three diploids [B. rapa (A genome), B. nigra (B), and B. oleracea (C)] and derived allotetraploids [B. juncea (AB genome), B. napus (AC), and B. carinata (BC)]. However, comprehensive understanding of Brassica genome evolution has not been fully achieved. Here, we performed low-coverage (2-6×) whole-genome sequencing of 28 accessions of Brassica as well as of Raphanus sativus [R genome] to explore the evolution of six Brassica species based on chloroplast genome and ribosomal DNA variations...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743060/antrodia-cinnamomea-extract-inhibits-the-proliferation-of-tamoxifen-resistant-breast-cancer-cells-through-apoptosis-and-skp2-micrornas-pathway
#15
Yu-Shih Lin, Yin-Yin Lin, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Cheng-Nan Lu, Geng-He Chang, Ming-Shao Tsai, Cheng-Ming Hsu, Reming-Albert Yeh, Pei-Rung Yang, I-Yun Lee, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Kuan-Der Lee, De-Ching Chang, Ching-Yuan Wu
BACKGROUND: Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to treat ER-positive breast tumors. However, remissions of breast cancer are often followed by resistance to tamoxifen and disease relapse. Despite the increasing understanding of the resistance mechanisms, effective regimens for treating tamoxifen-resistant breast cancer are limited...
May 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29737474/incidence-and-risk-factors-for-congestive-heart-failure-in-patients-with-early-breast-cancer-who-received-anthracycline-and-or-trastuzumab-a-big-data-analysis-of-the-korean-health-insurance-review-and-assessment-service-database
#16
Jung Yoon Choi, Eun Young Cho, Yoon Ji Choi, Jeong Hyeon Lee, Seung Pil Jung, Kyu Ran Cho, Chul Yong Kim, Yeul Hong Kim, Kyong Hwa Park
PURPOSE: We aimed to analyze the incidence, time to occurrence, and congestive heart failure (CHF) risk factors for early breast cancer patients treated with anthracycline (AC)-based chemotherapy and/or trastuzumab (T) therapy in Korea. METHODS: We included female patients > 19 years old from the Health Insurance Review and Assessment Service database who had no prior CHF history and had been diagnosed with early breast cancer between January 2007 and October 2016...
May 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29735867/the-accuracies-of-abdominal-computed-tomography-and-the-neutrophil-to-lymphocyte-ratio-used-to-predict-the-development-of-clinically-severe-acute-cholecystitis-in-elderly-patients-visiting-an-emergency-department
#17
S H Woo, W J Lee, S H Seol, D H Kim, S P Choi
Background: Mortality in patients with severe acute cholecystitis (AC) remains high, and the prognosis for elderly patients tends to be poor. A comparative analysis of clinical, laboratory, and abdominal computed tomography (CT) parameters was conducted in this study to investigate the effectiveness of each index for predicting clinically severe AC in elderly patients in the emergency department (ED). Methods: This was a single-center, retrospective study that included 156 patients (≥65 years of age) with AC who were admitted in the ED between January 2012 and December 2014...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29734629/air-pollution-exposure-during-pregnancy-and-ultrasound-and-birth-measures-of-fetal-growth-a-prospective-cohort-study-in-korea
#18
Dirga Kumar Lamichhane, Jia Ryu, Jong-Han Leem, Mina Ha, Yun-Chul Hong, Hyesook Park, Yangho Kim, Dal-Young Jung, Ji-Young Lee, Hwan-Cheol Kim, Eun-Hee Ha
Few studies have examined the effects of air pollution on fetal growth based on ultrasound measures during pregnancy. More data is needed to evaluate the windows of special vulnerability. Our aim was to investigate the association of ambient air pollution during pregnancy with fetal and neonatal characteristics in a cohort of Korean women. Maternal exposure to particulate matter with an aerodynamic diameter<10μm (PM10 ) and nitrogen dioxide (NO2 ) was estimated using land-use regression models based on residential address...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29733103/improvement-in-abdominal-and-flank-contouring-by-a-novel-adipocyte-selective-non-contact-radiofrequency-device
#19
Sun Young Choi, Young Jae Kim, So Yeon Kim, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Chonghyun Won
BACKGROUND: The demand for undergoing subcutaneous fat reduction has been gradually increasing, and there are many methods and devices for performing non-surgical and non-invasive fat reduction, such as high-intensity focused ultrasound, cryolipolysis, radiofrequency (RF) devices, and lasers. OBJECTIVES: This study evaluated the efficacy and safety of a novel adipocyte-selective non-contact RF device for improving abdominal contouring in Asian subjects. METHODS: Twenty-four Asian subjects with abundant subcutaneous abdominal and love handle fat tissues were enrolled in this prospective clinical study...
May 7, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29709111/c-h-alkenylation-of-pyrroles-by-electronically-matching-ligand-control
#20
Hyun Tae Kim, Woohyeong Lee, Eunmin Kim, Jung Min Joo
Directing group and substrate control strategies have frequently been employed for the regioselective C-H alkenylation of acid- and oxidant-sensitive pyrrole heterocycles. We developed an undirected, aerobic strategy for the C-H alkenylation of N-alkylpyrroles by ligand control. For C2-alkenylation of electron-rich N-alkylpyrroles, an electrophilic palladium catalyst derived from Pd(OAc)2 and 4,5-diazafluoren-9-one (DAF) was used. Alternatively, a combination of Pd(OAc)2 and a mono-protected amino acid ligand, Ac-Val-OH, was useful for C5-alkenylation of N-alkylpyrroles possessing electron-withdrawing groups at the C2 position...
April 30, 2018: Chemistry, An Asian Journal
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