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https://www.readbyqxmd.com/read/29319402/interaction-of-metabolic-health-and-obesity-on-subclinical-target-organ-damage
#1
Hyun-Jung Lee, Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
BACKGROUND: Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness. METHODS: A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29310490/harnessing-electronic-medical-records-to-advance-research-on-multiple-sclerosis
#2
Vincent Damotte, Antoine Lizée, Matthew Tremblay, Alisha Agrawal, Pouya Khankhanian, Adam Santaniello, Refujia Gomez, Robin Lincoln, Wendy Tang, Tiffany Chen, Nelson Lee, Pablo Villoslada, Jill A Hollenbach, Carolyn D Bevan, Jennifer Graves, Riley Bove, Douglas S Goodin, Ari J Green, Sergio E Baranzini, Bruce Ac Cree, Roland G Henry, Stephen L Hauser, Jeffrey M Gelfand, Pierre-Antoine Gourraud
BACKGROUND: Electronic medical records (EMR) data are increasingly used in research, but no studies have yet evaluated similarity between EMR and research-quality data and between characteristics of an EMR multiple sclerosis (MS) population and known natural MS history. OBJECTIVES: To (1) identify MS patients in an EMR system and extract clinical data, (2) compare EMR-extracted data with gold-standard research data, and (3) compare EMR MS population characteristics to expected MS natural history...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29297315/utilizing-random-forest-qsar-models-with-optimized-parameters-for-target-identification-and-its-application-to-target-fishing-server
#3
Kyoungyeul Lee, Minho Lee, Dongsup Kim
BACKGROUND: The identification of target molecules is important for understanding the mechanism of "target deconvolution" in phenotypic screening and "polypharmacology" of drugs. Because conventional methods of identifying targets require time and cost, in-silico target identification has been considered an alternative solution. One of the well-known in-silico methods of identifying targets involves structure activity relationships (SARs). SARs have advantages such as low computational cost and high feasibility; however, the data dependency in the SAR approach causes imbalance of active data and ambiguity of inactive data throughout targets...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29279598/secondary-polycythaemia-in-a-malay-girl-with-homozygous-hb-tak
#4
H S Amran, M A Aziz, E George, N Mahmud, T Y Lee, S Md Noor
Hb Tak is one of more than 200 high affinity haemoglobin variants reported worldwide. It results from the insertion of two nucleotides (AC) at the termination codon, between codon 146 and codon 147 of the beta-globin gene [Beta 147 (+AC)]. Polycythaemia is the main clinical feature although affected carriers are usually asymptomatic and do not require intervention. Several case studies in this region have reported the co-inheritance of Hb Tak with Hb E, delta beta and beta thalassaemia with one case of homozygous Hb Tak in a Thai boy...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29250374/crystal-structure-of-4-meth-oxy-n-piperidine-1-carbono-thio-yl-benzamide
#5
Khairi Suhud, Siti Aishah Hasbullah, Musa Ahmad, Lee Yook Heng, Mohammad B Kassim
In the title compound, C14H18N2O2S, the piperidine ring has a chair conformation. Its mean plane is twisted with respect to the 4-meth-oxy-benzoyl ring, with a dihedral angle of 63.0 (3)°. The central N-C(=S)-N(H)-C(=O) bridge is twisted with an N-C-N-C torsion angle of 74.8 (6)°. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds, forming chains along the c-axis direction. Adjacent chains are linked by C-H⋯π inter-actions, forming layers parallel to the ac plane. The layers are linked by offset π-π inter-actions [inter-centroid distance = 3...
October 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29226969/cudratricusxanthone-a-attenuates-sepsis-induced-liver-injury-via-sirt1-signaling
#6
Yuri Lee, Gil-Saeng Jeong, Wonhwa Lee, Jong-Sup Bae
Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudraniatricuspidata Bureau, is known to possess antithrombotic, antiproliferative and antiinflammatory activities. It remains unclear that CTXA can improve hepatoprotective activity in vivo. The objective of this study was to investigate the effect of CTXA on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate its underlying molecular mechanisms. Liver failure was induced by LPS (15 mg/kg, i.p.) in mice, and 12 h later, they were treated intravenously with CTXA...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215347/locally-preserved-%C3%AE-%C3%A2-%C3%AE-phase-transition-in-natural-radiation-damaged-titanite-catisio-sub-5-sub-evidence-from-laser-induced-photoluminescence-and-dielectric-measurements
#7
Tobias Beirau, Dawid Murawski, Harald Behrens, Ekhard K H Salje, Lee A Groat, Ronny Kaden, Herbert Pöllmann, Ulrich Bismayer
In situ temperature-dependent laser-induced photoluminescence and dielectric measurements provide new evidence for the local occurrence of the α → β phase transition near 500 K in the preserved crystalline parts of natural radiation-damaged titanite (sample E2335 with ~ 24% amorphous fraction, containing Fe and Al impurities). Photoluminescence spectroscopic measurements show an anomaly in the vicinity of 500 K. The temperature-dependent evolution of the real part of the electrical conductivity (σ) and the real (ε̍) and the imaginary (ε̎) part of the complex dielectric permittivity (ε*) of titanite have been measured at various AC frequencies (~ 1...
December 7, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29185344/highly-efficient-deep-uv-light-emitting-diodes-using-aln-based-deep-uv-transparent-glass-electrodes
#8
Tae Ho Lee, Byeong Ryong Lee, Kyung Rock Son, Hee Woong Shin, Tae Geun Kim
Many studies have set out to develop electrodes that are both highly conductive and transparent across a wide spectral region, from visible to deep-UV (DUV). However, few solutions have been proposed because these two properties are mutually exclusive. In this paper, an AlN-based glass electrode film with a conducting filament formed by the application of an AC pulse is proposed as a solution, which exhibits a high transmittance in the DUV region (over 95.6 % at 280 nm) and a low contact resistance with a p-Al0...
November 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29184283/does-treadmill-walking-with-near-infrared-light-applied-to-the-abdominal-area-reduce-local-adiposity-and-body-weight
#9
Sungwoon Kim, Yujin Kim, Gyusung Lee, Jingu Kim
[Purpose] The purpose of this study was to determine the effect on local fat deposition and body weight of wearing a near-infrared light belt around the abdomen. [Subjects and Methods] Twenty-eight obese female subjects participated in this experiment. For measurement of body composition, an impedance-style body fat analyzer was used. The experimental group performed treadmill walking 3 times per week for 12 weeks while wearing an activated near-infrared belt around the abdomen. The near-infrared belt was composed of light-emitting diodes having wavelengths of 630 nm, 830 nm, 880 nm, and 956 nm...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29183828/musical-expectations-enhance-auditory-cortical-processing-in-musicians-a-magnetoencephalography-study
#10
Jeong Mi Park, Chun Kee Chung, June Sic Kim, Kyung Myun Lee, Jaeho Seol, Suk Won Yi
The present study investigated the influence of musical expectations on auditory representations in musicians and non-musicians using magnetoencephalography (MEG). Neuroscientific studies have demonstrated that musical syntax is processed in the inferior frontal gyri, eliciting an early right anterior negativity (ERAN), and anatomical evidence has shown that interconnections occur between the frontal cortex and the belt and parabelt regions in the auditory cortex (AC). Therefore, we anticipated that musical expectations would mediate neural activities in the AC via an efferent pathway...
November 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/29166574/altered-tnf-%C3%AE-response-by-aconibal-%C3%A2-and-methotrexate-in-a-lipopolysaccharide-induced-setting-of-inflammatory-conditions-potential-on-a-synergistic-combination
#11
Gunhyuk Park, Seoung Hoon Lee, Ji-Ye Han, Dal-Seok Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum carmichaelii (AC) is a common herbal medicine used as anti-inflammatory and analgesic agent in Eastern Asia. In Korea, a commercial processed AC (Aconibal(®)) is traditionally used to treat the symptoms of spondylosis deformans and rheumatic pain. AIM OF STUDY: Rheumatoid arthritis (RA) is systemic and auto-immune disease characterized by chronic inflammation. Methotrexate (MTX) is often the first-line therapy for RA. If MTX monotherapy is ineffective or RA is initially severe, adding a tumor necrosis factor (TNF)-α inhibitor to the treatment can be beneficial...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29153717/biomass-derived-porous-carbon-modified-glass-fiber-separator-as-polysulfide-reservoir-for-li-s-batteries
#12
Ramakrishnan Kalai Selvan, Pei Zhu, Chaoi Yan, Jiadeng Zhu, Mahmut Dirican, A Shanmugavani, Yun Sung Lee, Xiangwu Zhang
Biomass-derived porous carbon has been considered as a promising sulfur host material for lithium-sulfur batteries because of its high conductive nature and large porosity. The present study explored biomass-derived porous carbon as polysulfide reservoir to modify the surface of glass fiber (GF) separator. Two different carbons were prepared from Oak Tree fruit shells by carbonization with and without KOH activation. The KOH activated porous carbon (AC) provides a much higher surface area (796 m(2) g(-1)) than pyrolized carbon (PC) (334 m(2) g(-1))...
November 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153660/fetal-size-and-growth-velocity-in-chronic-hypertension
#13
T Frusca, S Parolini, A Dall'Asta, W A Hassan, A Vitulo, A Gillett, D Pasupathy, C C Lees
OBJECTIVE: To investigate longitudinal fetal growth and growth velocity for commonly measured biometric parameters in women with chronic hypertension. METHODS: Two centre retrospective European study of women with chronic hypertension ascertained at pregnancy booking. Ultrasound measurements of head circumference (HC), abdominal circumference (AC) and femur length (FL) were used to derive longitudinal fetal growth charts derived using functional linear discriminant analysis (FLDA)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29150239/tissue-resident-macrophages-are-locally-programmed-for-silent-clearance-of-apoptotic-cells
#14
Allison W Roberts, Bettina L Lee, Jacques Deguine, Shinu John, Mark J Shlomchik, Gregory M Barton
Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll-like receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms. Here we identified macrophage populations that continually engulf ACs in distinct tissues and found that these macrophages share characteristics compatible with immunologically silent clearance of ACs; such characteristics include high expression of AC recognition receptors, low expression of TLR9, and reduced TLR responsiveness to nucleic acids...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29138786/electroconvection-of-pure-nematic-liquid-crystals-without-free-charge-carriers
#15
Kuang-Wu Lee, Thorsten Pöschel
We consider electroconvection as a response of nematic liquid crystals to an external electric AC field, in the absence of free charge carriers. Previous experimental and theoretical results emphasized charge carriers as a necessary precondition of electroconvection because free-charges in the fluid can respond to an external electric field. Therefore, ionized molecules are considered as responsible for the driving of electroconvective flows. In experiments, finite conductivity is achieved by adding charge-carrying dye molecules or in non-dyed liquid crystals by impurities of the samples...
November 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/29138698/soluble-epoxide-hydrolase-inhibitor-and-14-15-epoxyeicosatrienoic-acid-facilitated-long-term-potentiation-through-camp-and-camkii-in-the-hippocampus
#16
Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin
Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH). The role of EETs in synaptic function in the central nervous system is still largely unknown. We found that pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 14,15-EET significantly increased the field excitatory postsynaptic potential (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and forskolin- (FSK-) induced LTP...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29135231/solid-semisolid-and-liquid-phase-states-of-individual-submicrometer-particles-directly-probed-using-atomic-force-microscopy
#17
Hansol D Lee, Kamal K Ray, Alexei V Tivanski
Currently, the impact of various phase states of aerosols on the climate is not well understood, especially for submicrometer sized aerosol particles that typically have extended lifetime in the atmosphere. This is largely due to the inherent size limitations present in current experimental techniques that aim to directly assess the phase states of fine aerosol particles. Herein we present a technique that uses atomic force microscopy to probe directly for the phase states of individual, submicrometer particles by using nanoindentation and nano-Wilhelmy methodologies as a function of relative humidity (RH) and ambient temperature conditions...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29130578/sirt3-deregulation-is-linked-to-mitochondrial-dysfunction-in-alzheimer-s-disease
#18
Junghee Lee, Yunha Kim, Tian Liu, Yu Jin Hwang, Seung Jae Hyeon, Hyeonjoo Im, Kyungeun Lee, Victor E Alvarez, Ann C McKee, Soo-Jong Um, Manwook Hur, Inhee Mook-Jung, Neil W Kowall, Hoon Ryu
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between mitochondrial pathology and neuronal damage is poorly understood. Sirtuins (SIRT, silent mating type information regulation 2 homolog in yeast) are NAD-dependent histone deacetylases involved in aging and longevity. The objective of this study was to investigate the relationship between SIRT3 and mitochondrial function and neuronal activity in AD...
November 11, 2017: Aging Cell
https://www.readbyqxmd.com/read/29126106/airvf-a-filtering-toolbox-for-precise-variant-calling-in-ion-torrent-sequencing
#19
Sunguk Shin, Hanna Lee, Hyeonju Son, Soonmyung Paik, Sangwoo Kim
Summary: Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and industry. Despite many advantages, platform-specific artifacts complicate efficient separation of true variants from errors, especially in variants with lower allele frequencies (<15%). Here, we developed a multi-step filtering toolbox AIRVF that works on flowgram, raw and mapped reads and called variants to reduce artifact-driven false variant calls. Tests on sequencing data of standard reference material showed up to ∼98% reduction of false variants when combined to conventional public pipelines and ∼48% to the in-house commercial solution, with a minimal loss of sensitivity...
November 6, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29124092/dataset-of-the-livability-performance-of-the-city-of-birmingham-uk-as-measured-by-its-citizen-wellbeing-resource-security-resource-efficiency-and-carbon-emissions
#20
Joanne M Leach, Susan E Lee, Christopher T Boyko, Claire J Coulton, Rachel Cooper, Nicholas Smith, Hélène Joffe, Milena Büchs, James D Hale, Jonathan P Sadler, Peter A Braithwaite, Luke S Blunden, Valeria De Laurentiis, Dexter V L Hunt, AbuBakr S Bahaj, Katie Barnes, Christopher J Bouch, Leonidas Bourikas, Marianna Cavada, Andrew Chilvers, Stephen J Clune, Brian Collins, Ellie Cosgrave, Nick Dunn, Jane Falkingham, Patrick James, Corina Kwami, Martin Locret-Collet, Francesca Medda, Adriana Ortegon, Serena Pollastri, Cosmin Popan, Katerina Psarikidou, Nick Tyler, John Urry, Yue Wu, Victoria Zeeb, Chris D F Rogers
This data article presents the UK City LIFE1 data set for the city of Birmingham, UK. UK City LIFE1 is a new, comprehensive and holistic method for measuring the livable sustainability performance of UK cities. The Birmingham data set comprises 346 indicators structured simultaneously (1) within a four-tier, outcome-based framework in order to aid in their interpretation (e.g., promote healthy living and healthy long lives, minimize energy use, uncouple economic vitality from CO2 emissions) and (2) thematically in order to complement government and disciplinary siloes (e...
December 2017: Data in Brief
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