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https://www.readbyqxmd.com/read/28290664/differential-pharmacophore-definition-of-the-camp-binding-sites-of-ncs-rapgef2-pka-and-epac-in-neuroendocrine-cells-using-an-adenine-based-scaffold
#1
Andrew Clayton Emery, Ryan A Alvarez, Maribeth V Eiden, Wenqin Xu, Fabrice G Simeon, Lee E Eiden
We recently reported that the adenylate cyclase (AC) inhibitor SQ22,536 (9-tetrahydrofuranyl-adenine) also has inhibitory activity against the neuroendocrine-specific neuritogenic cAMP sensor-Rapgef2 (NCS-Rapgef2), a guanine nucleotide exchanger and activator for the small effector GTPase Rap1. Cell-based assays that distinguish signaling through the three intracellular cAMP sensors NCS-Rapgef2, exchange protein activated by cAMP (Epac), and protein kinase A (PKA), as well as AC, were used. These, collectively, assess the activities of adenine (6-amino-purine) derivatives modified at several positions to enhance selectivity for NCS-Rapgef2 by decreasing affinity for adenylate cyclase (AC), without increasing affinity for PKA or Epac...
March 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28287748/colossal-terahertz-magnetoresistance-at-room-temperature-in-epitaxial-la0-7sr0-3mno3-nanocomposites-and-single-phase-thin-films
#2
J Lloyd-Hughes, Connor Mosley, Samuel Jones, Martin R Lees, Aiping Chen, Quanxi Jia, Eun Mi Choi, Judith L MacManus Driscoll
Colossal magnetoresistance (CMR) is demonstrated at terahertz (THz) frequencies by using terahertz time-domain magnetospectroscopy to examine nanocolumns and planar thin films of La0.7Sr0.3MnO3. At the metal-insulator transition the THz conductivity of the nanocolumn film was dramatically enhanced by the application of a magnetic field, creating a non-Drude conductivity that increased with frequency. The colossal magnetoresistance at 1.0THz is -99.9% at the Curie temperature (room temperature), far exceeding the dc magnetoresistance...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28241745/drug-voyager-a-computational-platform-for-exploring-unintended-drug-action
#3
Min Oh, Jaegyoon Ahn, Taekeon Lee, Giup Jang, Chihyun Park, Youngmi Yoon
BACKGROUND: The dominant paradigm in understanding drug action focuses on the intended therapeutic effects and frequent adverse reactions. However, this approach may limit opportunities to grasp unintended drug actions, which can open up channels to repurpose existing drugs and identify rare adverse drug reactions. Advances in systems biology can be exploited to comprehensively understand pharmacodynamic actions, although proper frameworks to represent drug actions are still lacking. RESULTS: We suggest a novel platform to construct a drug-specific pathway in which a molecular-level mechanism of action is formulated based on pharmacologic, pharmacogenomic, transcriptomic, and phenotypic data related to drug response ( http://databio...
February 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28230162/n-acetylated-proline-glycine-proline-accelerates-cutaneous-wound-healing-and-neovascularization-by-human-endothelial-progenitor-cells
#4
Yang Woo Kwon, Soon Chul Heo, Tae Wook Lee, Gyu Tae Park, Jung Won Yoon, Il Ho Jang, Seung-Chul Kim, Hyun-Chang Ko, Youngjae Ryu, Hyeona Kang, Chang Man Ha, Sang Chul Lee, Jae Ho Kim
Human endothelial progenitor cells (hEPCs) are promising therapeutic resources for wound repair through stimulating neovascularization. However, the hEPCs-based cell therapy has been hampered by poor engraftment of transplanted cells. In this study, we explored the effects of N-acetylated Proline-Glycine-Proline (Ac-PGP), a degradation product of collagen, on hEPC-mediated cutaneous wound healing and neovascularization. Treatment of hEPCs with Ac-PGP increased migration, proliferation, and tube-forming activity of hEPCs in vitro...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216094/fusion-of-flagellin-2-with-bivalent-white-spot-syndrome-virus-vaccine-increases-survival-in-freshwater-shrimp
#5
Hansam Cho, Na Hye Park, Yuyeon Jang, Yong-Dae Gwon, Yeondong Cho, Yoon-Ki Heo, Ki-Hoon Park, Hee-Jung Lee, Tae Jin Choi, Young Bong Kim
Despite large economic losses attributable to white spot syndrome virus (WSSV), an infectious pathogen of penaeid shrimp and other crustaceans worldwide, no efficient vaccines or antiviral agents to control the virus are available at present. Here, we designed and constructed baculovirus-based vaccines delivering genes encoding the WSSV envelope proteins, VP28 and VP19. To enhance the immunogenicity of the baculovirus-based vaccine, we fused a Salmonella typhimurium flagellin 2 (FL2) gene with VP28 or VP19 gene...
March 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28186098/postnatal-height-and-adiposity-gain-childhood-blood-pressure-and-prehypertension-risk-in-an-asian-birth-cohort
#6
I M Aris, J Y Bernard, L-W Chen, M T Tint, W Y Lim, S E Soh, S-M Saw, L P-C Shek, K M Godfrey, P D Gluckman, Y-S Chong, F Yap, M S Kramer, Y S Lee
OBJECTIVE: There have been hypotheses that early life adiposity gain may influence blood pressure (BP) later in life. We examined associations between timing of height, body mass index (BMI) and adiposity gains in early life with BP at 48 months in an Asian pregnancy-birth cohort. METHODS: In 719 children, velocities for height, BMI and abdominal circumference (AC) were calculated at five intervals [0-3, 3-12, 12-24, 24-36 and 36-48 months]. Triceps (TS) and subscapular skinfold (SS) velocities were calculated between 0-18, 18-36 and 36-48 months...
March 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28184254/npcare-database-of-natural-products-and-fractional-extracts-for-cancer-regulation
#7
Hwanho Choi, Sun Young Cho, Ho Jeong Pak, Youngsoo Kim, Jung-Yun Choi, Yoon Jae Lee, Byung Hee Gong, Yeon Seok Kang, Taehoon Han, Geunbae Choi, Yeeun Cho, Soomin Lee, Dekwoo Ryoo, Hwangseo Park
BACKGROUND: Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified. DESCRIPTION: NPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28178647/enhancement-of-trail-induced-apoptosis-by-5-fluorouracil-requires-activating-bax-and-p53-pathways-in-trail-resistant-lung-cancers
#8
Uddin Md Nazim, Rasheduzzaman Md, You-Jin Lee, Dai-Wu Seol, Sang-Youel Park
Lung cancer, especially lung adenocarcinoma, is one of the main causes of death worldwide. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a primary anticancer agent and a member of the tumor necrosis factor family that selectively induces apoptosis in various tumor cells, but not in normal cells. Combination chemotherapy can be used for treating specific cancer types even at progressive stages. In the present study, we observed that 5-fluorouracil, which exerts anticancer effects by inhibiting tumor cell proliferation, enhanced TRAIL-induced apoptosis of TRAIL-resistant human adenocarcinoma A549 cells...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28173641/effects-of-adamantyl-derivatives-on-pharmacokinetic-behavior-of-paclitaxel-in-rats
#9
Kyung Mi Kim, Kyeong Lee, Kyusic Jang, Yae Seul Moon, Hwa Jeong Lee, Sandy Jeong Rhie
Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded by very low bioavailability (<5%) due to the P-glycopprotein (P-gp) efflux pump effect. This study investigated in vitro and in vivo P-gp inhibitory effects of adamantyl derivatives AC-603 and AC-786 in rats. Two adamantyl derivatives tested in this study increased the cytotoxicity of daunomycin (DNM) in P-gp overexpressed cell line by inhibiting P-gp efflux function...
February 6, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28167568/pathologic-complete-response-with-neoadjuvant-doxorubicin-and-cyclophosphamide-followed-by-paclitaxel-with-trastuzumab-and-pertuzumab-in-patients-with-her2-positive-early-stage-breast-cancer-a-single-center-experience
#10
Jasmeet C Singh, Anita Mamtani, Andrea Barrio, Monica Morrow, Steven Sugarman, Lee W Jones, Anthony F Yu, Daniel Argolo, Lilian M Smyth, Shanu Modi, Sarah Schweber, Camilla Boafo, Sujata Patil, Larry Norton, Jose Baselga, Clifford A Hudis, Chau Dang
OBJECTIVES: Trastuzumab (H) and pertuzumab (P) with standard chemotherapy is approved for use in the neoadjuvant setting for human epidermal growth receptor 2 -positive patients. A retrospective analysis was performed of patients treated with dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T), trastuzumab, and pertuzumab (THP) in the neoadjuvant setting. Here, the pathologic complete response (pCR) rates are reported. METHODS: An electronic medical record review was conducted of patients treated with HP-based therapy in the neoadjuvant setting from September 1, 2013, to March 1, 2015...
February 2017: Oncologist
https://www.readbyqxmd.com/read/28167293/ethanol-extract-of-the-seed-of-zizyphus-jujuba-var-spinosa-potentiates-hippocampal-synaptic-transmission-through-mitogen-activated-protein-kinase-adenylyl-cyclase-and-protein-kinase-a-pathways
#11
So Yeon Jo, In Ho Jung, Jee Hyun Yi, Tae Joon Choi, Seungheon Lee, Ji Wook Jung, Jeanho Yun, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
ETHNOPHARMACOLOGICAL RELEVANCE: As the seed of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) has been used to sleep disturbances in traditional Chinese and Korean medicine, many previous studies have focused on its sedative effect. AIM OF THE STUDY: Recently, we reported the neuroprotective effect of the effect of Z. jujuba var. spinosa. However, its effects on synaptic function have not yet been studied. In this project, we examined the action of ethanol extract of the seed of Z...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28162806/a-neural-circuit-for-auditory-dominance-over-visual-perception
#12
You-Hyang Song, Jae-Hyun Kim, Hye-Won Jeong, Ilsong Choi, Daun Jeong, Kwansoo Kim, Seung-Hee Lee
When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that audition dominates vision in a process mediated by interaction between inputs from the primary visual (VC) and auditory (AC) cortices in the posterior parietal cortex (PTLp). Co-activation of the VC and AC suppresses VC-induced PTLp responses, leaving AC-induced responses...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28160860/novel-effect-and-the-mechanistic-insights-of-fruiting-body-extract-of-medicinal-fungus-antrodia-cinnamomea-against-t47d-breast-cancer
#13
Kuang-Ming Shang, Tzu-Hsuan Su, Wai Leng Lee, Wen-Wei Hsiao, Ching-Yi Chiou, Bing-Ying Ho, Sheng-Yang Wang, Lie-Fen Shyur
INTRODUCTION: Tamoxifen, an anti-oestrogenic drug for estrogen receptor positive (ER+) breast cancer, was observed to stimulate tumor growth or drug resistance in patients. Antrodia cinnamomea (AC), a precious medicinal fungus has been traditionally used as a folk remedy for cancers in Asian countries. The objective of this study was to investigate the bioefficacy and the underlying molecular mechanisms of the AC fruiting bodies extracts (AC-3E) against human ER+ T47D breast cancer cells, and compare the effect with that of tamoxifen...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28155707/prioritizing-biological-pathways-by-recognizing-context-in-time-series-gene-expression-data
#14
Jusang Lee, Kyuri Jo, Sunwon Lee, Jaewoo Kang, Sun Kim
BACKGROUND: The primary goal of pathway analysis using transcriptome data is to find significantly perturbed pathways. However, pathway analysis is not always successful in identifying pathways that are truly relevant to the context under study. A major reason for this difficulty is that a single gene is involved in multiple pathways. In the KEGG pathway database, there are 146 genes, each of which is involved in more than 20 pathways. Thus activation of even a single gene will result in activation of many pathways...
December 23, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28140356/spin-glass-behavior-in-frustrated-quantum-spin-system-cual2o4-with-a-possible-orbital-liquid-state
#15
R Nirmala, Kwang-Hyun Jang, Hasung Sim, Hwanbeom Cho, Junghwan Lee, Nam-Geun Yang, Seongsu Lee, R M Ibberson, K Kakurai, M Matsuda, S-W Cheong, V V Gapontsev, S V Streltsov, Je-Geun Park
CuAl2O4 is a normal spinel oxide having quantum spin, S  =  1/2 for Cu(2+). It is a rather unique feature that the Cu(2+) ions of CuAl2O4 sit at a tetrahedral position, not like the usual octahedral position for many oxides. At low temperatures, it exhibits all the thermodynamic evidence of a quantum spin glass. For example, the polycrystalline CuAl2O4 shows a cusp centered at ~2 K in the low-field dc magnetization data and a clear frequency dependence in the ac magnetic susceptibility while it displays logarithmic relaxation behavior in a time dependence of the magnetization...
January 31, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28133755/evaluation-of-motion-mitigation-using-abdominal-compression-in-the-clinical-implementation-of-pencil-beam-scanning-proton-therapy-of-liver-tumors
#16
Liyong Lin, Kevin Souris, Minglei Kang, Adam Glick, Haibo Lin, Sheng Huang, Kristin Stützer, Guillaume Janssens, Edmond Sterpin, John A Lee, Timothy D Solberg, James E McDonough, Charles B Simone, Edgar Ben-Josef
PURPOSE: To determine whether individual liver tumor patients can be safely treated with pencil beam scanning proton therapy. This study reports a planning preparation workflow that can be used for beam angle selection and the evaluation of the efficacy of abdominal compression (AC) to mitigate motion. METHODS: Four-dimensional computed tomography scans (4DCT) with and without AC were available from 10 liver tumor patients with fluoroscopy-proven motion reduction by AC, previously treated using photons...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28126553/korean-red-ginseng-improves-testicular-ineffectiveness-in-aging-rats-by-modulating-spermatogenesis-related-molecules
#17
Spandana Rajendra Kopalli, Kyu-Min Cha, Ji-Hoon Ryu, Sang-Ho Lee, Min-Sik Jeong, Seock-Yeon Hwang, Young-Joo Lee, Hee-Won Song, Su-Nam Kim, Jin-Chul Kim, Si-Kwan Kim
Korean red ginseng (Panax ginseng Meyer) is known to rejuvenate testicular effectiveness and the sperm maturation process by regulating redox proteins in aged rats. This study was performed to investigate the effect of Korean red ginseng water extract (KRG-WE) on the expression level of spermatogenesis-related key biomolecules and sex hormone receptors as well as enzymes regulating oxidation, histone deacetylation, and growth-related activities in aged rat testis. KRG-WE (200mg/kg) mixed with a regular pellet diet was administered to 12-month-old rats for 6months (KRG-AC), whereas the young (YC, 2months) and aged (AC, 12months) controls received the vehicle only...
April 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28125738/antimelanogenic-antioxidant-and-antiproliferative-effects-of-antrodia-camphorata-fruiting-bodies-on-b16-f0-melanoma-cells
#18
Jyh-Jye Wang, Chih-Chung Wu, Chun-Lin Lee, Shu-Ling Hsieh, Jin-Bor Chen, Chu-I Lee
Antrodia camphorata is a fungus that is endemic to Taiwan, and its fruiting body has been used as a folk medicine for the prevention or treatment of diverse diseases. The present study is aimed at investigating the antimelanogenesis and antioxidation effect of the ethanolic extract of Antrodia camphorata fruiting body (EE-AC), as well as its antiproliferation effects in B16-F0 melanoma cells. Regarding antimelanogenic effects, EE-AC had effective cupric ions reducing capacity and expressed more potent inhibitory effect than kojic acid on mushroom tyrosinase activity...
2017: PloS One
https://www.readbyqxmd.com/read/28125100/utility-of-third-trimester-sonographic-measurements-for-predicting-sga-in-cases-of-fetal-gastroschisis
#19
Y J Blumenfeld, S Do, A I Girsen, A S Davis, S R Hintz, A K Desai, T Mansour, T A Merritt, B T Oshiro, Y Y El-Sayed, A A Shamshirsaz, H C Lee
OBJECTIVE: To assess the accuracy of different sonographic estimated fetal weight (EFW) cutoffs, and combinations of EFW and biometric measurements for predicting small for gestational age (SGA) in fetal gastroschisis. STUDY DESIGN: Gastroschisis cases from two centers were included. The sensitivity, specificity, positive and negative predictive values (PPV and NPV) were calculated for different EFW cutoffs, as well as EFW and biometric measurement combinations...
January 26, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28111598/the-mpeg-pcl-copolymer-for-selective-fermentation-of-staphylococcus-lugdunensis-against-candida-parapsilosis-in-the-human-microbiome
#20
Ming-Shan Kao, Yanhan Wang, Shinta Marito, Stephen Huang, Wan-Zhen Lin, Jon A Gangoiti, Bruce A Barshop, Choi Hyun, Woan-Ruah Lee, James A Sanford, Richard L Gallo, Yuping Ran, Wan-Tzu Chen, Chun-Jen Huang, Ming-Fa Hsieh, Chun-Ming Huang
Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide novel therapeutics to rein in the over-growth of fungi. Staphylococcus lugdunensis (S. lugdunensis) bacteria and Candida parapsilosis (C...
August 2016: Journal of microbial & biochemical technology
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