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Raman spectroscopy AND clinical application

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https://www.readbyqxmd.com/read/29083121/in-vitro-label-free-screening-of-chemotherapeutic-drugs-using-raman-micro-spectroscopy-towards-a-new-paradigm-of-spectralomics
#1
REVIEW
Z Farhane, H Nawaz, F Bonnier, H J Byrne
This overview groups some of the recent studies highlighting the potential application of Raman micro-spectroscopy as an analytical technique in preclinical development to predict drug mechanism of action and in clinical application as a companion diagnostic and in personalised therapy due to its capacity to predict cellular resistance and therefore to optimise chemotherapeutic treatment efficacy. Notably, the anthracyclines, Doxorubicin and Actinomycin D, elicit similar spectroscopic signatures of subcellular interaction characteristic of the mode of action of intercalation...
October 30, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28889318/human-axillary-skin-condition-is-improved-following-incorporation-of-glycerol-into-the-stratum-corneum-from-an-antiperspirant-formulation
#2
Richard L Evans, Graham A Turner, Susan Bates, Teresa Robinson, David Arnold, Robert E Marriott, Paul D A Pudney, Eleanor Y M Bonnist, Darren Green
The study objectives were to demonstrate that glycerol, when topically applied from a roll-on antiperspirant formulation, can be delivered directly to human skin ex vivo and the axillary stratum corneum (SC) in vivo, and to assess whether it improves the quality of the axillary skin barrier. Ex vivo human skin absorption of glycerol was measured following application of a roll-on antiperspirant formulation containing 4% (13)C3-glycerol. Skin distribution of (13)C3-glycerol over 24 h was assessed using gas chromatography-mass spectrometry...
September 9, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28886805/using-raman-spectroscopy-to-detect-and-diagnose-skin-cancer-in%C3%A2-vivo
#3
REVIEW
Jianhua Zhao, Haishan Zeng, Sunil Kalia, Harvey Lui
Raman spectroscopy provides a noninvasive bedside tool that captures unique optical signals via molecular vibrations in tissue samples. Raman theory was discovered at the beginning of the twentieth century, but it was not until the past few decades that it has been used to differentiate skin neoplasms. We provide a brief description of Raman spectroscopy for in vivo skin cancer diagnosis, including the physical principles underlying Raman spectroscopy, its advantages, typical spectra of skin pathologies, and its clinical application for aiding skin cancer diagnosis...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28852131/raman-spectroscopy-uncovers-biochemical-tissue-related-features-of-extracellular-vesicles-from-mesenchymal-stromal-cells
#4
Alice Gualerzi, Stefania Niada, Chiara Giannasi, Silvia Picciolini, Carlo Morasso, Renzo Vanna, Valeria Rossella, Massimo Masserini, Marzia Bedoni, Fabio Ciceri, Maria Ester Bernardo, Anna Teresa Brini, Furio Gramatica
Extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) are emerging as valuable therapeutic agents for tissue regeneration and immunomodulation, but their clinical applications have so far been limited by the technical restraints of current isolation and characterisation procedures. This study shows for the first time the successful application of Raman spectroscopy as label-free, sensitive and reproducible means of carrying out the routine bulk characterisation of MSC-derived vesicles before their use in vitro or in vivo, thus promoting the translation of EV research to clinical practice...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825612/development-and-testing-of-an-led-based-near-infrared-sensor-for-human-kidney-tumor-diagnostics
#5
Andrey Bogomolov, Urszula Zabarylo, Dmitry Kirsanov, Valeria Belikova, Vladimir Ageev, Iskander Usenov, Vladislav Galyanin, Olaf Minet, Tatiana Sakharova, Georgy Danielyan, Elena Feliksberger, Viacheslav Artyushenko
Optical spectroscopy is increasingly used for cancer diagnostics. Tumor detection feasibility in human kidney samples using mid- and near-infrared (NIR) spectroscopy, fluorescence spectroscopy, and Raman spectroscopy has been reported (Artyushenko et al., Spectral fiber sensors for cancer diagnostics in vitro. In Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 21-25 June 2015). In the present work, a simplification of the NIR spectroscopic analysis for cancer diagnostics was studied...
August 19, 2017: Sensors
https://www.readbyqxmd.com/read/28820221/real-time-monitoring-of-plasmon-induced-proton-transfer-of-hypoxanthine-in-serum
#6
Binbin Zhou, Shaofei Li, Xianghu Tang, Pan Li, Xiaomin Cao, Borong Yu, Liangbao Yang, Jinhuai Liu
Intramolecular proton transfer of hypoxanthine, induced by application of a laser on the surface of a bare noble nanomaterial, was monitored in real time using surface-enhanced Raman spectroscopy (SERS). This monitoring demonstrated the dependence of the reaction on the identity of the nanomaterial and on the laser power density. The results pave the way for monitoring the proton transfer reaction in various relevant fields. In addition, we observed the presence of the proton transfer phenomenon of hypoxanthine in serum, providing a way to avoid the effect of proton transfer and hence achieve more reliable spectra of sera for clinical diagnosis...
August 31, 2017: Nanoscale
https://www.readbyqxmd.com/read/28751073/efficacy-of-new-natural-biomodification-agents-from-anacardiaceae-extracts-on-dentin-collagen-cross-linking
#7
M A Moreira, N O Souza, R S Sousa, D Q Freitas, M V Lemos, D M De Paula, F J N Maia, D Lomonaco, S E Mazzetto, V P Feitosa
OBJECTIVES: Several polyphenols from renewable sources were surveyed for dentin biomodification. However, phenols from cashew nut shell liquid (CNSL, Anacardium occidentale) and from Aroeira (Myracrodruon urundeuva) extract have never been evaluated. The present investigation aimed to compare the dentin collagen crosslinking (biomodification) effectiveness of polyphenols from Aroeira stem bark extract, proanthocyanidins (PACs) from grape-seed extract (Vitis vinifera), cardol and cardanol from CNSL after clinically relevant treatment for one minute...
July 24, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28749450/evaluation-of-shifted-excitation-raman-difference-spectroscopy-and-comparison-to-computational-background-correction-methods-applied-to-biochemical-raman-spectra
#8
Eliana Cordero, Florian Korinth, Clara Stiebing, Christoph Krafft, Iwan W Schie, Jürgen Popp
Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. However, a challenge for in vivo applications is the simultaneous excitation of auto-fluorescence in the majority of tissues of interest, such as liver, bladder, brain, and others. Raman bands are then superimposed on a fluorescence background, which can be several orders of magnitude larger than the Raman signal...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28744123/skeleton-labeled-13-c-carbon-nanoparticles-for-the-imaging-and-quantification-in-tumor-drainage-lymph-nodes
#9
Ping Xie, Qian Xin, Sheng-Tao Yang, Tiantian He, Yuanfang Huang, Guangfu Zeng, Maosheng Ran, Xiaohai Tang
Carbon nanoparticles (CNPs) have been widely used in tumor drainage lymph node (TDLN) imaging, drug delivery, photothermal therapy, and so on. However, during the theranostic applications, the accumulation efficiency of CNPs in target organs is unknown yet, which largely hinders the extension of CNPs into clinical uses. Herein, we prepared skeleton-labeled (13)C-CNPs that had identical properties to commercial CNPs suspension injection (CNSI) for the imaging and quantification in TDLN. (13)C-CNPs were prepared by arc discharge method, followed by homogenization with polyvinylpyrrolidone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28726868/raman-spectroscopy-for-cancer-detection-and-cancer-surgery-guidance-translation-to-the-clinics
#10
REVIEW
Inês P Santos, Elisa M Barroso, Tom C Bakker Schut, Peter J Caspers, Cornelia G F van Lanschot, Da-Hye Choi, Martine F van der Kamp, Roeland W H Smits, Remco van Doorn, Rob M Verdijk, Vincent Noordhoek Hegt, Jan H von der Thüsen, Carolien H M van Deurzen, Linetta B Koppert, Geert J L H van Leenders, Patricia C Ewing-Graham, Helena C van Doorn, Clemens M F Dirven, Martijn B Busstra, Jose Hardillo, Aniel Sewnaik, Ivo Ten Hove, Hetty Mast, Dominiek A Monserez, Cees Meeuwis, Tamar Nijsten, Eppo B Wolvius, Robert J Baatenburg de Jong, Gerwin J Puppels, Senada Koljenović
Oncological applications of Raman spectroscopy have been contemplated, pursued, and developed at academic level for at least 25 years. Published studies aim to detect pre-malignant lesions, detect cancer in less invasive stages, reduce the number of unnecessary biopsies and guide surgery towards the complete removal of the tumour with adequate tumour resection margins. This review summarizes actual clinical needs in oncology that can be addressed by spontaneous Raman spectroscopy and it provides an overview over the results that have been published between 2007 and 2017...
July 20, 2017: Analyst
https://www.readbyqxmd.com/read/28686212/raman-plus-x-biomedical-applications-of-multimodal-raman-spectroscopy
#11
REVIEW
Nandan K Das, Yichuan Dai, Peng Liu, Chuanzhen Hu, Lieshu Tong, Xiaoya Chen, Zachary J Smith
Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical tool has been slow, hampered by fundamental Raman scattering issues such as long integration times and limited penetration depth. In this review we detail the how combining Raman spectroscopy with other techniques yields multimodal instruments that can help to surmount the translational barriers faced by Raman alone...
July 7, 2017: Sensors
https://www.readbyqxmd.com/read/28686040/differentiation-between-staphylococcus-aureus-and-staphylococcus-epidermidis-strains-using-raman-spectroscopy
#12
Katarína Rebrošová, Martin Šiler, Ota Samek, Filip Růžička, Silvie Bernatová, Jan Ježek, Pavel Zemánek, Veronika Holá
AIM: Raman spectroscopy is an analytical method with a broad range of applications across multiple scientific fields. We report on a possibility to differentiate between two important Gram-positive species commonly found in clinical material - Staphylococcus aureus and Staphylococcus epidermidis - using this rapid noninvasive technique. MATERIALS & METHODS: For this, we tested 87 strains, 41 of S. aureus and 46 of S. epidermidis, directly from colonies grown on a Mueller-Hinton agar plate using Raman spectroscopy...
August 2017: Future Microbiology
https://www.readbyqxmd.com/read/28676880/innovations-and-developments-in-dermatologic-non-invasive-optical-imaging-and-potential-clinical-applications
#13
Eric Tkaczyk
Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all these optical diagnostic technologies and then details 4 of the lesser known innovations that are already available or still in development (laser Doppler and speckle imaging, Raman spectroscopy, multiphoton microscopy, photoacoustic tomography), with some potential applications in clinical dermatology (blood flow monitoring, skin cancer diagnosis, composition measurements in atopic dermatitis, skin rejuvenation measurement, and noninvasive sentinel lymph node assessment in melanoma)...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28649013/online-quantitative-monitoring-of-live-cell-engineered-cartilage-growth-using-diffuse-fiber-optic-raman-spectroscopy
#14
Mads S Bergholt, Michael B Albro, Molly M Stevens
Tissue engineering (TE) has the potential to improve the outcome for patients with osteoarthritis (OA). The successful clinical translation of this technique as part of a therapy requires the ability to measure extracellular matrix (ECM) production of engineered tissues in vitro, in order to ensure quality control and improve the likelihood of tissue survival upon implantation. Conventional techniques for assessing the ECM content of engineered cartilage, such as biochemical assays and histological staining are inherently destructive...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28639667/recent-progress-in-surface-enhanced-raman-spectroscopy-for-biological-and-biomedical-applications-from-cells-to-clinics
#15
REVIEW
D Cialla-May, X-S Zheng, K Weber, J Popp
The application of surface-enhanced Raman spectroscopy (SERS) in biological and biomedical detection schemes is feasible due to its excellent molecular specificity and high sensitivity as well as the capability of SERS to be performed in complex biological compositions. SERS-based investigation of cells, which are the basic structure and functional unit of organisms, represents the starting point of this review. It is demonstrated that SERS provides a deep understanding of living cells as well as their microenvironment which is needed to assess the development of diseases...
June 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28635172/doxorubicin-kinetics-and-effects-on-lung-cancer-cell-lines-using-in-vitro-raman-micro-spectroscopy-binding-signatures-drug-resistance-and-dna-repair
#16
Zeineb Farhane, Franck Bonnier, Orla Howe, Alan Casey, Hugh J Byrne
Raman micro-spectroscopy is a non-invasive analytical tool, whose potential in cellular analysis and monitoring drug mechanisms of action has already been demonstrated, and which can potentially be used in pre-clinical and clinical applications for the prediction of chemotherapeutic efficacy. To further investigate such potential clinical application, it is important to demonstrate its capability to differentiate drug mechanisms of action and cellular resistances. Using the example of Doxorubicin (DOX), in this study, it was used to probe the cellular uptake, signatures of chemical binding and subsequent cellular responses, of the chemotherapeutic drug in two lung cancer cell lines, A549 and Calu-1...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28600775/diagnostic-bacteriology-raman-spectroscopy
#17
Rebecca L Pavlicek, Nicole J Crane, Meron Ghebremedhin, Katherine E Cilwa, Eric A Elster
Current clinical methodology for identification of bacterial infections relies predominantly on culturing microbes from patient material and performing biochemical tests. This can often be an inefficient and lengthy process, which has a significant detrimental effect upon patient care. Techniques used in other aspects of molecular research have the potential to revolutionize the way in which diagnostic tests are used and delivered in the clinical setting. The need for rapid, accurate, and cost-effective molecular techniques in the diagnostic laboratory is imperative to improving patient care, preventing the spread of drug resistance and decreasing the overall burden associated with nosocomial infections...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28505414/quantitative-online-liquid-chromatography-surface-enhanced-raman-scattering-lc-sers-of-methotrexate-and-its-major-metabolites
#18
Abdu Subaihi, Drupad K Trivedi, Katherine A Hollywood, James Bluett, Yun Xu, Howbeer Muhamadali, David I Ellis, Royston Goodacre
The application of Raman spectroscopy as a detection method coupled with liquid chromatography (LC) has recently attracted considerable interest, although this has currently been limited to isocratic elution. The combination of LC with rapidly advancing Raman techniques, such as surface-enhanced Raman scattering (SERS), allows for rapid separation, identification and quantification, leading to quantitative discrimination of closely eluting analytes. This study has demonstrated the utility of SERS in conjunction with reversed-phase liquid chromatography (RP-LC), for the detection and quantification of the therapeutically relevant drug molecule methotrexate (MTX) and its metabolites 7-hydroxy methotrexate (7-OH MTX) and 2,4-diamino-N(10)-methylpteroic acid (DAMPA) in pure solutions and mixtures, including spikes into human urine from a healthy individual and patients under medication...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28464521/on-chip-spectroscopic-assessment-of-microbial-susceptibility-to-antibiotics-within-3-5%C3%A2-hours
#19
Ulrich-Christian Schröder, Johanna Kirchhoff, Uwe Hübner, Günter Mayer, Uwe Glaser, Thomas Henkel, Wolfgang Pfister, Wolfgang Fritzsche, Jürgen Popp, Ute Neugebauer
In times of rising antibiotic resistances, there is a high need for fast, sensitive and specific methods to determine antibiotic susceptibilities of bacterial pathogens. Here, we present an integrated microfluidic device in which bacteria from diluted suspensions are captured in well-defined regions using on-chip dielectrophoresis and further analyzed in a label-free and non-destructive manner using Raman spectroscopy. Minimal sample preparation and automated sample processing ensure safe handling of infectious material with minimal hands-on time for the operator...
May 2, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28440049/analytical-based-methodologies-for-examining-the-in-vitro-absorption-distribution-metabolism-and-elimination-adme-of-silver-nanoparticles
#20
Sesha L A Paluri, John D Ryan, Nhi H Lam, Dhriti Nepal, Ioana E Sizemore
The clinical applications of silver nanoparticles (AgNPs) remain limited due to the lack of well-established methodologies for studying their nanokinetics. Hereby, the primary goal is to adapt a suite of analytical-based methodologies for examining the in vitro absorption, distribution, metabolism, and elimination of AgNPs. Vero 76 and HEK 293 cells are exposed to ≈10-nm spherical AgNPs(+) and AgNPs(-) at relevant concentrations (0-300 µg mL(-1) ) and times (4-48 h). Absorption: Inductively coupled plasma optical emission spectroscopy (ICP-OES) demonstrates that the two AgNP formulations are not bioequivalent...
April 25, 2017: Small
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