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https://www.readbyqxmd.com/read/28931318/thyroid-function-testing-in-neonates-with-maternal-history-of-disease
#1
Lisa Underland, Lisa Kenigsberg, Kristina Derrick, Rebecca Crespi, Tara Kaushal, Leslie Lam
Maternal history of thyroid disease can cause congenital hypothyroidism due to thyroid-stimulatng hormone (TSH) blocking antibodies. No guidelines exist regarding testing beyond the newborn screen. TSH and T4 levels exhibit significant fluctuations after birth which complicates testing. A total of 561 newborns with thyroid function testing done for maternal history of thyroid disease in the newborn nursery were identified retrospectively via chart review, and thyroid disease status was assessed in 352. Newborn screening data were also obtained...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28919625/van-wyk-and-grumbach-syndrome-an-unusual-presentation-of-hypothyroism
#2
P K Chanda, M Kamrul-Hasan, M Abu-Bakar, M Rahman, M A Kader, M A Hossain, N I Siddiqui
An 18 years-old-girl presented one and half years back with the complaints of short stature, retarded growth, and menorrhagia with sudden severe lower abdominal pain; was diagnosed as bilateral ovarian cysts and underwent bilateral ovarian cystectomy. Later on she was incidentally diagnosed as a case of hypothyroidism when she had been experiencing slowly enlarging left lower abdominal mass with dull ache for the 5 month and then was transferred to the department of Endocrinology for further evaluation. Detailed work up revealed her short stature with obesity, delayed bone age and other features of hypothyroidism which was confirmed by thyroid function testing...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28911144/randomized-trial-comparing-two-algorithms-for-levothyroxine-dose-adjustment-in-pregnant-women-with-primary-hypothyroidism
#3
Shannon D Sullivan, Erin Downs, Geanina Popoveniuc, Alexander Zeymo, Jacqueline Jonklaas, Kenneth D Burman
Context: Regulation of maternal thyroid hormones during pregnancy is crucial for optimal maternal and fetal outcomes. There are no specific guidelines addressing maternal levothyroxine (LT4) dose adjustments throughout pregnancy. Objective: To compare two LT4 dose-adjustment algorithms in hypothyroid pregnant women. Design: Thirty-three women on stable LT4 doses were recruited at <10 weeks gestation during 38 pregnancies and randomized to one of two dose-adjustment groups...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28905202/drug-interactions-in-users-of-tablet-vs-oral-liquid-levothyroxine-formulations-a-real-world-evidence-study-in-primary-care
#4
Valeria Guglielmi, Alfonso Bellia, Elisa Bianchini, Gerardo Medea, Iacopo Cricelli, Paolo Sbraccia, Davide Lauro, Claudio Cricelli, Francesco Lapi
PURPOSE: Several medications may interact with levothyroxine (LT4) intestinal absorption or metabolism, thus reducing its bioavailability. We investigated the variability of thyroid stimulating hormone (TSH) levels and prescribed daily dosages (PDDs) of LT4 before and during potential drug-drug interactions (DDIs) in users of tablets vs. oral liquid LT4 formulations. METHODS: By using the Italian general practice Health Search Database (HSD), we retrospectively selected adult patients with at least one LT4 prescription from 2012 to 2015 and at least 1 year of clinical history recorded...
September 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28904805/high-dose-levothyroxine-for-the-management-of-bipolar-affective-disorder-two-case-reports
#5
Andy Zamar, Gurvinder Warrya, Christos Kouimtsidis
In this article, we report two cases from our centre: case A has the longest recovery period and case B is one of the most complex from a diagnostic and management perspective, highlighting how treatment resistance can be overcome depending on patient response and needs.
September 2017: JRSM Open
https://www.readbyqxmd.com/read/28894436/serum-thyroid-hormone-antibodies-are-frequent-in-patients-with-polyglandular-autoimmune-syndrome-type-3-particularly-in-those-who-require-thyroxine-treatment
#6
Roberto Vita, Maria Giulia Santaguida, Camilla Virili, Maria Segni, Marina Galletti, Mattia Mandolfino, Flavia Di Bari, Marco Centanni, Salvatore Benvenga
Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison's disease and hypoparathyroidism. We evaluated the prevalence and repertoire of thyroid hormones antibodies (THAb) in PAS-3 patients. Using a radioimmunoprecipation technique, we measured THAb (T3IgM, T3IgG, T4IgM, and T4IgG) in 107 PAS-3 patients and 88 controls (patients with AITD without any NTAID). Based on the selective coexistence of AITD with one NTAID (chronic autoimmune gastritis, non-segmental vitiligo or celiac disease), patients were divided into group 1 (chronic autoimmune gastritis positive, n = 64), group 2 (non-segmental vitiligo positive, n = 24), and group 3 (celiac disease positive, n = 15)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28892955/frequent-occurrence-of-faulty-practices-misconceptions-and-lack-of-knowledge-among-hypothyroid-patients
#7
A Goel, C Shivaprasad, A Kolly, A A Pulikkal, R Boppana, C S Dwarakanath
INTRODUCTION: Hypothyroidism is a common endocrine disorder with a reported prevalence of 4%-10%. Previous studies have reported significant gaps in the basic knowledge about the condition in hypothyroid patients. It has also been observed that faulty practices prevail among these patients. There is paucity of data on the assessment of knowledge and practices among treated hypothyroid patients. AIM: The present study was aims to assess the knowledge, awareness and practices in treated hypothyroid patients...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28884595/risk-of-osteoporosis-in-thyroid-cancer-patients-using-levothyroxine-a-population-based-study
#8
Shih-Yi Lin, Cheng-Li Lin, Hsien-Te Chen, Chia-Hung Kao
BACKGROUND: The outcomes of thyroid cancer patients using levothyroxine are largely undetermined. METHODS: The study population consisted of 9,398 patients newly diagnosed with thyroid cancer; their data was retrieved from a subset of the National Health Insurance Research Database of Taiwan during the period of 1999-2011. In this nationwide retrospective cohort study, we compared the risk of osteoporosis among thyroid cancer patients with levothyroxine use, those without levothyroxine use, and propensity score-matched nonthyroid controls...
September 8, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28883260/a-case-of-metastatic-follicular-thyroid-carcinoma-complicated-with-graves-disease-after-total-thyroidectomy
#9
Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa, Akira Tangoku
Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28882111/tsh-cut-off-point-based-on-depression-in-hypothyroid-patients
#10
A Talaei, N Rafee, F Rafei, A Chehrei
BACKGROUND: The prevalence of depressive symptoms in hypothyroidism is high. Considering that hypothyroidism and depression share some clinical features, some researchers use the "brain hypothyroidism" hypothesis to explain the pathogenesis of depression. We aimed to detect a new TSH cut-off value in hypothyroidism based on depression symptoms. METHODS: A cross-sectional study was conducted on hypothyroid patients referred to endocrine clinics. Individuals who had developed euthyroid state under treatment with levothyroxine with TSH levels of 0...
September 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28878841/thyroid-association-ophthalmopathy-in-hashimoto-s-thyroiditis-a-case-report
#11
Deepak Jain, Sudhir Mor, Hari Krishan Aggarwal, Pulkit Chhabra, Promil Jain
Thyroid associated ophthalmopathy is a constellation of symptoms caused by an autoimmune process involving the orbital tissue. It is common in hyperthyroid patients due to Graves' disease and also reported in euthyroid and hypothyroid Graves' patients with positive thyroid receptor antibodies. But in Hashimoto's thyroiditis, thyroid associated ophthalmopathy is a rarely reported and poorly understood entity. Here we report thyroid associated ophthalmopathy in a patient with hypothyroidism and negative thyroid receptor antibodies who showed heterogeneously hypoechoic thyroid gland on ultrasonography, diffuse lymphocytic infiltrate on fine needle aspiration citology and reduced 99m Tc radioisotope uptake, supporting the diagnosis of Hashimoto's thyroiditis...
January 2017: Mædica
https://www.readbyqxmd.com/read/28870235/soy-isoflavones-inducing-overt-hypothyroidism-in-a-patient-with-chronic-lymphocytic-thyroiditis-a-case-report
#12
Yuya Nakamura, Isao Ohsawa, Yoshikazu Goto, Mayumi Tsuji, Tatsunori Oguchi, Naoki Sato, Yuji Kiuchi, Motonori Fukumura, Masahiro Inagaki, Hiromichi Gotoh
BACKGROUND: Many people have thyroid conditions that make them susceptible to hypothyroidism. If the foods they eat may interfere with the production of thyroid hormone, which can lead to development of serious hypothyroidism. The danger of health drinks should always be noted. CASE PRESENTATION: A 72-year-old Japanese woman was previously diagnosed with chronic lymphocytic thyroiditis caused by a goiter and had an elevated thyroid-stimulating hormone level (6.56 μIU/ml), a high anti-thyroid peroxidase antibody level (>600 IU/ml), and a high antithyroglobulin level (> 4000 IU/ml) but normal levels of free triiodothyronine (3...
September 5, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28868522/primary-care-provider-management-of-congenital-hypothyroidism-identified-through-newborn-screening
#13
N A Rosenthal, E Bezar, S Mann, L K Bachrach, S Banerjee, M E Geffner, M Gottschalk, S K Shapira, L Hasegawa, L Feuchtbaum
OBJECTIVE: To assess Primary Congenital Hypothyroidism (CH) management patterns and feasibility of providing long-term care for patients with CH identified through newborn screening by Primary Care Providers (PCPs) in California and Hawaii. STUDY DESIGN: A survey was mailed to all physicians (N=823) listed as the referral doctor for confirmed patients with CH identified through newborn screening programs in both states between 01/01/2009-12/31/2013. Information was collected on CH management patterns, barriers to providing care, and knowledge on CH treatment...
2017: Ann Thyroid Res
https://www.readbyqxmd.com/read/28863875/-hypothyroidism-in-adults-in-a-basic-health-area
#14
I López-Macías, A Hidalgo-Requena, E Pérez-Membrive, M E González-Rodríguez, C Bellido-Moyano, L A Pérula-de Torres
INTRODUCTION: The objective of the present study is to study the prevalence, as well as the clinical and epidemiological characteristics of hypothyroid disease in adults using the computerised clinical records. MATERIAL AND METHODS: Observational, descriptive and cross-sectional study. The target population was the patients of the health centres of Lucena I and II (Córdoba). INCLUSION CRITERIA: Patients 14 years or older, diagnosed with hypothyroidism, born and resident in Lucena...
August 29, 2017: Semergen
https://www.readbyqxmd.com/read/28856598/erratum-to-gluten-and-aluminum-content-in-synthroid-%C3%A2-levothyroxine-sodium-tablets
#15
Ramon Espaillat, Michael F Jarvis, Cory Torkelson, Brent Sinclair
No abstract text is available yet for this article.
September 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28846851/the-regulation-of-pituitary-thyroid-abnormalities-by-peripheral-administration-of-levothyroxine-increased-bdnf-and-reelin-proteins-expression-in-an-animal-model-of-alzheimer-s-disease
#16
Sahreh Shabani, Yaghoub Farbood, Seyyed Ali Mard, Alireza Sarkaki, Akram Ahangarpour, Layasadat Khorsandi
Alzheimer's disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH) and decreased in protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hippocampus. In this study, we have evaluated the effect of subcutaneously (SC) administration of levothyroxine (L-T4) on levels of THs and TSH as well as protein expression of BDNF and reelin in AD rats. To make an animal model of AD, Beta-amyloid (Aβ) plus ibotenic acid were infused intrahippocampally (IH), and rats were treated with L-T4 and/or saline for 10 days...
August 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28835757/avoiding-misdiagnosis-due-to-antibody-interference-with-serum-free-thyroxin
#17
Pilar I Beato-Víbora, S Alejo-González
INTRODUCTION: Interfering antibodies are capable of causing potentially misleading results in automated thyroid hormone immunoassays. CASE PRESENTATION: We report the case of a 46- year-old female patient with autoimmune hypothyroidism in chronic replacement treatment with levothyroxine who was presented 8 years after diagnosis with a thyroid function test showing an increased level of TSH and a very high level of FT4. Interference in the laboratory serum free thyroxin (FT4) test was suspected, due to the lack of symptoms of hyperthyroidism and a different immunoassay platform confirmed a low FT4 result...
January 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28835510/a-systematic-review-of-performance-enhancing-pharmacologicals-and-biotechnologies-in-the-army
#18
REVIEW
Henry Ko, K E Hunter, A M Scott, M Ayson, M L Willson
INTRODUCTION: In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel. METHODS: Searches for studies examining biotechnological and pharmacological products in Army populations were conducted in December 2015. Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO were searched without date or language restrictions...
August 22, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28835258/acute-hypopituitarism-associated-with-periorbital-swelling-and-cardiac-dysfunction-in-a-patient-with-pituitary-tumor-apoplexy-a-case-report
#19
Nobumasa Ohara, Yuichiro Yoneoka, Yasuhiro Seki, Katsuhiko Akiyama, Masataka Arita, Kazumasa Ohashi, Kazuo Suzuki, Toshinori Takada
BACKGROUND: Pituitary tumor apoplexy is a rare clinical syndrome caused by acute hemorrhage or infarction in a preexisting pituitary adenoma. It typically manifests as an acute episode of headache, visual disturbance, mental status changes, cranial nerve palsy, and endocrine pituitary dysfunction. However, not all patients present with classical symptoms, so it is pertinent to appreciate the clinical spectrum of pituitary tumor apoplexy presentation. We report an unusual case of a patient with pituitary tumor apoplexy who presented with periorbital edema associated with hypopituitarism...
August 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28828345/evaluation-of-bone-density-serum-total-and-ionized-calcium-alkaline-phosphatase-and-25-hydroxy-vitamin-d-in-papillary-thyroid-carcinoma-and-their-relationship-with-tsh-suppression-by-levothyroxine
#20
Ali Kachui, Seyed Mashaallah Tabatabaizadeh, Bijan Iraj, Hasan Rezvanian, Awat Feizi
BACKGROUND: This study aimed to evaluate the situation of Bone Mineral Density (BMD), Z score, T score, serum level of corrected and ionized calcium, alkaline phosphatase and 25-hydroxy vitamin D in percutaneous transhepatic cholangiography (PTC) patients and correlation of these variants with thyroid stimulating hormone (TSH) suppression level by levothyroxine. MATERIALS AND METHODS: Among the patients referred to Esfahan's endocrinology research center, 34 PTC patients (aged 20-50 years) with a history of thyroidectomy and conceived radioactive iodine and suppressive dose of levothyroxine were evaluated in this case-control study, and 38 healthy persons participated as the control group (matched by age and sex, body mass index)...
2017: Advanced Biomedical Research
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