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https://www.readbyqxmd.com/read/28806795/in-older-adults-with-subclinical-hypothyroidism-levothyroxine-did-not-improve-symptoms-or-tiredness
#1
Reema Shah
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28800677/levothyroxine-enhances-glucose-clearance-and-blunts-the-onset-of-experimental-type-1-diabetes-mellitus-in-mice
#2
Livia López-Noriega, Nadia Cobo-Vuilleumier, Álvaro Jesús Narbona-Pérez, Juan Luis Araujo-Garrido, Petra Isabel Lorenzo, José Manuel Mellado-Gil, José Carlos Moreno, Benoit R Gauthier, Alejandro Martín-Montalvo
BACKGROUND AND PURPOSE: Thyroid hormones induce several changes in whole body metabolism that are known to improve metabolic homeostasis. However, adverse side effects have prevented its use in the clinic. In view of the promising effects of thyroid hormones, we investigated the effects of levothyroxine supplementation in glucose. EXPERIMENTAL APPROACH: C57BL/6 mice were treated with levothyroxine from birth to 24 weeks of age, when mice were euthanized. The effects of levothyroxine supplementation on metabolic health were determined...
August 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28794850/dual-control-of-pituitary-thyroid-stimulating-hormone-secretion-by-thyroxine-and-triiodothyronine-in-athyreotic-patients
#3
Rudolf Hoermann, John E M Midgley, Johannes W Dietrich, Rolf Larisch
BACKGROUND: Patient responses to levothyroxine (LT4) monotherapy vary considerably. We sought to differentiate contributions of FT4 and FT3 in controlling pituitary thyroid stimulating hormone (TSH) secretion. METHODS: We retrospectively assessed the relationships between TSH and thyroid hormones in 319 patients with thyroid carcinoma through 2914 visits on various LT4 doses during follow-up for 5.5 years (median, IQR 4.2, 6.9). We also associated patient complaints with the relationships...
June 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28782887/prevalence-of-treated-hypothyroidism-in-the-community-analysis-from-general-practices-in-north-east-england-with-implications-for-the-united-kingdom
#4
Lorna Ingoe, Norah Phipps, Gary Armstrong, Arvind Rajagopal, Farzan Kamali, Salman Razvi
OBJECTIVE: Hypothyroidism is more frequently diagnosed in women and older individuals. It has been suggested that the prevalence of hypothyroidism and the number of prescriptions for thyroid hormones are increasing. However, despite hypothyroidism being a common medical condition, contemporary data on prevalence, particularly across the various age groups, is limited. DESIGN: Information regarding number of individuals diagnosed with treated hypothyroidism (defined as patients prescribed levothyroxine) across ten General Practices (total population of 66,843) in the North-East of England in 2016 was obtained in an anonymised manner...
August 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28776582/thyroid-disease-in-pregnancy-new-insights-in-diagnosis-and-clinical-management
#5
REVIEW
Tim I M Korevaar, Marco Medici, Theo J Visser, Robin P Peeters
Adequate thyroid hormone availability is important for an uncomplicated pregnancy and optimal fetal growth and development. Overt thyroid disease is associated with a wide range of adverse obstetric and child development outcomes. An increasing number of studies now indicate that milder forms of thyroid dysfunction are also associated with these adverse pregnancy outcomes. The definitions of both overt and subclinical thyroid dysfunction have changed considerably over the past few years, as new data indicate that the commonly used fixed upper limits of 2...
August 4, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28774813/virtual-bioequivalence-for-achlorhydric-subjects-the-use-of-pbpk-modelling-to-assess-the-formulation-dependent-effect-of-achlorhydria
#6
Kosuke Doki, Adam S Darwich, Nikunjkumar Patel, Amin Rostami-Hodjegan
Majority of bioequivalence studies are conducted in healthy volunteers. It has been argued that bioequivalence may not necessarily hold true in relevant patient populations due to a variety of reasons which affect one formulation more than the other for instance in achlorhydric patients where elevated gastric pH may lead to differential effects on formulations which are pH-sensitive with respect to release or dissolution. We therefore examined achlorhydria-related disparity in bioequivalence of levothyroxine and nifedipine formulations using virtual bioequivalence within a physiologically-based pharmacokinetic (PBPK) modelling framework...
August 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28771438/fetal-goitrous-hypothyroidism-treated-by-intra-amniotic-levothyroxine-administration-case-report-and-review-of-the-literature
#7
Mami Kobayashi, Hideaki Yagasaki, Tomohiro Saito, Atsushi Nemoto, Atsushi Naito, Kanji Sugita
BACKGROUND: Fetal goitrous hypothyroidism is mainly caused by maternal treatment of Graves' disease. Fetal goiter sometimes compresses the trachea and esophagus and may cause polyhydramnios, preterm labor, complications of labor and delivery, and neonatal respiratory disorder. CASE PRESENTATION: We report a case of fetal goitrous hypothyroidism in which the mother had Graves' disease, which was treated with propylthiouracil. Intra-amniotic levothyroxine (L-T4) administration was performed, and the fetal goiter decreased in size...
August 3, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28766504/the-association-between-serum-tsh-levels-and-bmi-percentiles-in-children-with-primary-hypothyroidism-that-are-chemically-euthyroid-on-levothyroxine-replacement
#8
Asma Shaoba, Sanjib Basu, Stelios Mantis, Carla Minutti
OBJECTIVE: To determine if there is a association between TSH levels and BMI percentiles in children with primary hypothyroidism who are chemically euthyroid and on treatment with levothyroxine. METHODS: Retrospective cross-sectional study, consisting of review of medical records from RUSH Medical Center and Stroger Hospital, Chicago, IL, U.SA. Children (seen in clinic from 2008-2014) with primary hypothyroidism who were chemically euthyroid and on treatment with levothyroxine for at least 6 months were included in the study...
August 2, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28754607/reversal-of-nocturnal-non-dipping-of-blood-pressure-after-levothyroxine-therapy-in-patients-with-subclinical-hypothyroidism
#9
Mannmath Nath, Balram Gupta, Madhukar Rai, Surya K Singh
AIMS: To study the loss of diurnal variation in blood pressure in normotensive patients with Subclinical/overt hypothyroidism and effect of Levothyroxine (L-T4) treatment. MATERIALS AND METHODS: In this interventional study Eighty patients between 17- 50 years with newly detected OH and SCH (74 women and 6 men) and nine euthyroid subjects (all men) with blood pressure <140/90 were recruited. All patients underwent 24h ambulatory blood pressure monitoring (ABPM) using ABPM machine before and after treatment with L-T4...
July 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28749783/multinodular-goiter-in-children-treatment-controversies
#10
Emilio García-García, Mercedes López-González, Rosa Cabello-Laureano, Elena Navarro-González
BACKGROUND: Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages. METHODS: Two girls consulted for euthyroid colloid goiter, uninodular goiter and bilateral MG. They were intervened by hemithyroidectomy and total thyroidectomy, respectively, due to the existence of local symptoms...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28746798/thyroid-disease-symptoms-during-early-pregnancy-do-not-identify-women-with-thyroid-hypofunction-that-should-be-treated
#11
V J Pop, M A Broeren, W M Wiersinga, A Stagnaro-Green
OBJECTIVE: to evaluate whether women during early pregnancy with ''hypothyroidism'' symptoms are at risk for biochemical defined hypothyroidism. The 2017 guidelines of the American Thyroid Association (ATA) recommend case finding on the basis of symptoms to identify these women during pregnancy, while evidence is lacking. DESIGN: Construct validation of a thyroid hypofunction symptom checklist during first trimester of pregnancy comparing high scores with biochemical defined hypothyroidism...
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28746208/myopathy-in-hyperthyroidism-as-a-consequence-of-rapid-reduction-of-thyroid-hormone-a-case-report
#12
Qianrui Li, Yuping Liu, Qianying Zhang, Haoming Tian, Jianwei Li, Sheyu Li
RATIONALE: Myalgia and elevated creatine kinase (CK) are occasionally observed during the treatment of hyperthyroid patients. Relative hypothyroidism resulted from rapid thyroid hormone reduction had been promoted as a plausible cause of these myopathic changes, however rarely reported. PATIENT CONCERNS: We hereby presented a 20-year-old female with Grave's disease, who developed myopathy and elevated CK during rapid correction of thyroid hormone. DIAGNOSES: Relative hypothyroidism-induced myopathy...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28741453/no-effect-of-levothyroxine-and-levothyroxine-induced-subclinical-thyrotoxicosis-on-the-pharmacokinetics-of-sorafenib-in-healthy-male-subjects
#13
Funan Huang, Antoinette Ajavon-Hartmann, Erya Huang, John Lettieri, Rong Liu, Carol Pena, Matthias Berse
<b>Background</b>: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyroid-stimulating hormone (TSH) suppression. In the phase 3 DTC trial (DECISION), sorafenib exposure was ~2-fold higher than that observed in other cancers. We assessed sorafenib pharmacokinetics without and with concomitant levothyroxine to examine whether a levothyroxine interaction or levothyroxine-induced subclinical thyrotoxicosis results in increased sorafenib exposure in DTC patients...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28740481/refractory-hypothyroidism-due-to-improper-storage-of-levothyroxine-tablets
#14
Salvatore Benvenga, Giampaolo Papi, Alessandro Antonelli
CONTEXT: A not negligible part of hypothyroid patients on levothyroxine therapy do not normalize serum thyrotropin (TSH) concentrations. "Refractory hypothyroidism," i.e., a condition characterized by persistently abnormal serum TSH levels despite adequate titration of l-T4 substitution therapy, requires biochemical and instrumental investigation, but no definite etiology is found in up to 15% of cases. OBJECTIVE: To report patients presenting with refractory hypothyroidism with proven improper storage of levothyroxine tablets...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28738186/neonatal-screening-9-of-children-with-filter-paper-thyroid-stimulating-hormone-levels-between-5-and-10%C3%AE-iu-ml-have-congenital-hypothyroidism
#15
Flávia C Christensen-Adad, Carolina T Mendes-Dos-Santos, Maura M F Goto, Letícia E Sewaybricker, Lília F R D'Souza-Li, Gil Guerra-Junior, André M Morcillo, Sofia Helena V Lemos-Marini
OBJECTIVES: To determine the prevalence of congenital hypothyroidism in children with filter paper thyroid-stimulating hormone levels between 5 and 10μUI/mL in the neonatal screening. METHODS: This was a retrospective study including children screened from 2003 to 2010, with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum thyroid-stimulating hormone normalization...
July 21, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28716808/second-trimester-levothyroxine-treatment-for-subclinical-hypothyroidism-or-hypothyroxinaemia-of-pregnancy-does-not-improve-cognitive-outcomes-of-children
#16
Alex Stagnaro-Green
No abstract text is available yet for this article.
August 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28704192/risk-factors-for-postpartum-thyroid-dysfunction-in-euthyroid-women-prior-to-pregnancy
#17
Boyan I Nonchev, Antoaneta V Argatska, Blagovest K Pehlivanov, Maria M Orbetzova
BACKGROUND: Thyroid dysfunction is common during the postpartum and the predisposing factors for its development are considered specific for the population studied. The aim of this study was to evaluate the risk factors for the occurrence of postpartum thyroid dysfunction (PPTD) in euthyroid women prior to pregnancy. MATERIALS AND METHODS: Forty-five women with PPTD and 55 age-matched euthyroid postpartum women from Plovdiv, Bulgaria were included in the study. TSH, FT4, FT3, TPOAb, TgAb, TRAb were measured and ultrasound evaluation of the thyroid was performed in the first trimester of pregnancy and during the postpartum...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28697824/-analysis-of-treatment-efficacy-for-congenital-hypothyroidism-in-some-regions-of-yunnan-province-china
#18
Jing-Hui Yang, Jing-Hui Zhang, Yin-Hong Zhang, Xiao-Zhi Xu, Hong Chen, Yuan Li, Yan Jiang, Zheng Wang, Bao-Sheng Zhu, Li Li
OBJECTIVE: To observe the effects of initial doses and treatment timing of levothyroxine (L-T4) on the clinical efficacy in children with congenital hypothyroidism (CH). METHODS: This study included 98 children who had an abnormal level of thyroid stimulating hormone (TSH) in neonatal screening in four regions of Yunnan Province and who finally had a confirmed diagnosis of CH. They received treatment with L-T4 and were divided into standard dose group (10-15 μg/kg per day) and low dose group (<10 μg/kg per day) by the therapeutic dose of L-T4...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28695483/diagnosis-and-management-of-treatment-refractory-hypothyroidism-an-expert-consensus-report
#19
REVIEW
M Centanni, S Benvenga, I Sachmechi
There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients with unusual thyroxine needs is to escalate the dose of levothyroxine until targeted TSH levels are achieved...
July 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28690990/predictors-of-transient-congenital-hypothyroidism-in-children-with-eutopic-thyroid-gland
#20
Il Soon Park, Jong Seo Yoon, Cheol Hwan So, Hae Sang Lee, Jin Soon Hwang
PURPOSE: Congenital hypothyroidism (CH) is the most common cause of preventable mental retardation. Recently, the detection of CH cases with eutopic thyroid gland has increased due to neonatal screening programs. In this study, we aimed to identify and evaluate predictive factors that could distinguish between permanent and transient CH in patients with eutopic thyroid gland. METHODS: We retrospectively reviewed 100 children diagnosed with CH and with eutopic thyroid gland...
June 2017: Annals of Pediatric Endocrinology & Metabolism
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