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https://www.readbyqxmd.com/read/28434158/physical-performance-in-newly-diagnosed-hypothyroidism-a-pilot-study
#1
D Gallo, E Piantanida, G Veronesi, A Lai, L Sassi, V Lombardi, E Masiello, P Premoli, E Bianconi, C Cusini, S Rosetti, M L Tanda, A Toniolo, M Ferrario, L Bartalena
OBJECTIVE: Hypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests. MATERIALS AND METHODS: Fifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo)...
April 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28432797/effects-of-levothyroxine-administration-and-withdrawal-on-the-hypothalamic-pituitary-thyroid-axis-in-euthyroid-dogs
#2
V Ziglioli, D L Panciera, G C Troy, W E Monroe, K M Boes, K R Refsal
BACKGROUND: Chronic supplementation can suppress the hypothalamic-pituitary-thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine. OBJECTIVES: To determine whether the HPTA is suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression. ANIMALS: Twenty-eight healthy euthyroid dogs. METHODS: A prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2)...
April 22, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28425295/provider-and-patient-determinants-of-generic-levothyroxine-prescribing-an-electronic-health-records-based-study
#3
Robert J Romanelli, Vani Nimbal, Sarah K Dutcher, Xia Pu, Jodi B Segal
BACKGROUND: Despite the availability of generic levothyroxine products for more than a decade, uptake of these products is poor. OBJECTIVE: We sought to evaluate determinants of generic prescribing of levothyroxine. METHODS: In a cross-sectional analysis of electronic health records data between 2010 and 2013, we identified adult patients with a levothyroxine prescription from a primary-care physician (PCP) or endocrinologist. We used mixed-effect logistic regression models with random intercepts for prescribing provider to examine predictors of generic levothyroxine prescribing...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28420821/use-of-liothyronine-without-levothyroxine-in-the-treatment-of-mild-consumptive-hypothyroidism-caused-by-hepatic-hemangiomas
#4
Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa
There have been reports of the use of levothyroxine or levothyroxine plus liothyronine for consumptive hypothyroidism caused by hepatic hemangiomas. Administration of levothyroxine without liothyronine can be inadequate to maintain normal levels of both free T3 and free T4 in some patients. However, there is no report of treatment with liothyronine plus propranolol. We herein present a case in which we used liothyronine therapy for multifocal hepatic hemangiomas in a Japanese patient with low free T3 and normal free T4 levels...
April 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28412200/three-year-follow-up-of-children-with-abnormal-newborn-screening-results-for-congenital-hypothyroidism
#5
Min-Jae Kang, Hye-Rim Chung, Yeon-Joung Oh, Young-Suk Shim, Seung Yang, Il-Tae Hwang
BACKGROUND: To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS: A retrospective chart review of 105 subjects who presented elevated TSH levels on a newborn screening test (NST) was done. TCH was defined when a trial-off therapy was successful, and PCH was defined when a trial failed or when the subject was kept on medication beyond 3 years of age...
March 27, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28409722/complete-endoscopic-resection-of-a-pituitary-stalk-epidermoid-cyst-using-a-combined-infrasellar-interpituitary-and-suprasellar-endonasal-approach-case-report
#6
Ana C I Nakassa, Joseph D Chabot, Carl H Snyderman, Eric W Wang, Paul A Gardner, Juan C Fernandez-Miranda
Intracranial epidermoid cysts are benign lesions of epithelial origin that most frequently present with symptoms of mass effect. Although they are often associated with a high rate of residual tumor and recurrence, maximal safe resection usually leads to good outcomes. The authors report a complete resection of an uncommon pituitary stalk epidermoid cyst with intrasellar extension using a combined suprasellar and infrasellar interpituitary, endoscopic endonasal transsphenoidal approach. The patient, a 54-year-old woman, presented with headache, visual disturbance, and diabetes insipidus...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28407667/monitoring-thyroid-function-in-patients-on-levothyroxine-assessment-of-conformity-to-national-guidance-and-variability-in-practice
#7
Jonathan J Scargill, Mark Livingston, David Holland, Christopher J Duff, Anthony A Fryer, Adrian H Heald
With demand for endocrine tests steadily increasing year-on-year, we examined thyroid function test (TFT) frequencies in patients on levothyroxine replacement therapy to assess the effect of initial TFT results and request source on TFT re-testing interval. All TFTs performed by the Clinical Biochemistry Departments at the Salford Royal Hospital (2009-2012; 288 263 requests from 139 793 patients) and University Hospital of North Midlands (2011-2014; 579 156 requests from 193 035 patients) were extracted from the laboratory computer systems...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28407273/comorbidity-of-chronic-spontaneous-urticaria-and-autoimmune-thyroid-diseases-a-systematic-review
#8
REVIEW
Pavel Kolkhir, Martin Metz, Sabine Altrichter, Marcus Maurer
Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG anti-thyroid AAbs (strong evidence)...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28406057/subclinical-hypothyroidism-should-we-treat
#9
Christopher Redford, Bijay Vaidya
Subclinical hypothyroidism (also known as compensated hypothyroidism or mild hypothyroidism) is a condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4). It is common, affecting about 10% of women above the age of 55 years. Autoimmunity is the commonest cause of subclinical hypothyroidism. About 2.5% of patients with subclinical hypothyroidism progress to clinically overt hypothyroidism each year; the rate of progression is higher in patients with thyroid autoantibodies and higher thyroid stimulating hormone levels...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28402245/thyroid-hormone-therapy-for-older-adults-with-subclinical-hypothyroidism
#10
David J Stott, Nicolas Rodondi, Patricia M Kearney, Ian Ford, Rudi G J Westendorp, Simon P Mooijaart, Naveed Sattar, Carole E Aubert, Drahomir Aujesky, Douglas C Bauer, Christine Baumgartner, Manuel R Blum, John P Browne, Stephen Byrne, Tinh-Hai Collet, Olaf M Dekkers, Wendy P J den Elzen, Robert S Du Puy, Graham Ellis, Martin Feller, Carmen Floriani, Kirsty Hendry, Caroline Hurley, J Wouter Jukema, Sharon Kean, Maria Kelly, Danielle Krebs, Peter Langhorne, Gemma McCarthy, Vera McCarthy, Alex McConnachie, Mairi McDade, Martina Messow, Annemarie O'Flynn, David O'Riordan, Rosalinde K E Poortvliet, Terence J Quinn, Audrey Russell, Carol Sinnott, Jan W A Smit, H Anette Van Dorland, Kieran A Walsh, Elaine K Walsh, Torquil Watt, Robbie Wilson, Jacobijn Gussekloo
Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. Methods We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 μg daily, or 25 μg if the body weight was <50 kg or the patient had coronary heart disease), with dose adjustment according to the thyrotropin level; 369 patients were assigned to receive placebo with mock dose adjustment...
April 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28401798/most-frequently-reported-prescription-medications-and-supplements-in-couples-planning-pregnancy-the-life-study
#11
Kristin Palmsten, Katrina F Flores, Christina D Chambers, Lauren A Weiss, Rajeshwari Sundaram, Germaine M Buck Louis
OBJECTIVE: To identify frequently reported prescription medications and supplements among couples planning pregnancy because there is a lack of descriptive information on these agents in women and men who are trying to conceive. METHODS: Five hundred one couples enrolled in the Longitudinal Study of Infertility and the Environment, which took place between 2005 and 2009. Participants reported prescription medications as well as prescription and over-the-counter supplements used through interviews at study enrollment and through daily dairies during the 12-month follow-up...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28396245/application-of-a-handheld-nir-spectrometer-in-prediction-of-drug-content-in-inkjet-printed-orodispersible-formulations-containing-prednisolone-and-levothyroxine
#12
Hossein Vakili, Henrika Wickström, Diti Desai, Maren Preis, Niklas Sandler
Quality control tools to assess the quality of printable orodispersible formulations are yet to be defined. Four different orodispersible dosage forms containing two poorly soluble drugs, levothyroxine and prednisolone, were produced on two different edible substrates by piezoelectric inkjet printing. Square shaped units of 4cm(2) were printed in different resolutions to achieve an escalating drug dose by highly accurate and uniform displacement of droplets in picoliter range from the printhead onto the substrates...
April 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28393327/an-observational-study-of-110-elderly-lithium-treated-patients-followed-up-for-6%C3%A2-years-with-particular-reference-to-renal-function
#13
Alberto Bocchetta, Francesca Cabras, Martina Pinna, Antonio Poddighe, Claudia Sardu, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo
BACKGROUND: Recent observational studies have focused on lithium treatment in the elderly, with particular reference to safety in terms of thyroid and renal functions. The purpose of this study was to compare the clinical characteristics of patients starting lithium treatment before (N = 79) or after (N = 31) the age of 65 years. Patients were followed up for 6 years with focus on renal function and prescription of levothyroxine and methimazole. RESULTS: At baseline, median lithium serum concentration was 0...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28391432/thyroxine-exposure-effects-on-the-cranial-base
#14
Emily Durham, R Nicole Howie, Trish Parsons, Grace Bennfors, Laurel Black, Seth M Weinberg, Mohammed Elsalanty, Jack C Yu, James J Cray
Thyroid hormone is important for skull bone growth, which primarily occurs at the cranial sutures and synchondroses. Thyroid hormones regulate metabolism and act in all stages of cartilage and bone development and maintenance by interacting with growth hormone and regulating insulin-like growth factor. Aberrant thyroid hormone levels and exposure during development are exogenous factors that may exacerbate susceptibility to craniofacial abnormalities potentially through changes in growth at the synchondroses of the cranial base...
April 8, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28389458/probable-interaction-between-levothyroxine-and-ritonavir-case-report-and-literature-review
#15
Rahul Sahajpal, Rabia A Ahmed, Christine A Hughes, Michelle M Foisy
PURPOSE: A case of probable interaction of levothyroxine and ritonavir is presented along with a review of the relevant literature and recommendations on clinical management. SUMMARY: A 37-year-old woman with human immunodeficiency virus infection who had recently undergone thyroidectomy for a benign multinodular goiter presented to a clinic with hypothyroidism (she was also found to be pregnant), and treatment with levothyroxine 75 μg daily was initiated. While receiving antiretroviral therapy (abacavir-lamivudine and lopinavir-ritonavir) during pregnancy, the patient had persistently elevated serum thyroid-stimulating hormone (TSH) concentrations (up to 125...
April 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28385684/levothyroxine-shows-no-benefit-in-elderly-patients-with-subclinical-hypothyroidism-trial-finds
#16
Susan Mayor
No abstract text is available yet for this article.
April 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28381452/management-of-endocrine-disease-arguments-for-the-prolonged-use-of-antithyroid-drugs-in-children-with-graves-disease
#17
Juliane Leger, Jean-Claude Carel
Graves' disease is an autoimmune disorder. It is the major cause of hyperthyroidism but is rare in children. Patients are initially managed with antithyroid drugs (ATD), in the form of methimazole/carbimazole. A major disadvantage of ATD treatment is the high risk of relapse, exceeding 70% of children treated for a duration of two years, and the potential major side effects of the drug reported in exceptional cases. The major advantage of ATD treatment is that normal homeostasis of the hypothalamus-pituitary thyroid axis may be restored, with periods of drug treatment followed by freedom from medical intervention achieved in about 40 to 50% of cases after prolonged ATD treatment for several years in recent studies...
April 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28377378/evaluation-of-racial-and-socioeconomic-disparities-in-medication-pricing-and-pharmacy-access-and-services
#18
Marie A Chisholm-Burns, Christina A Spivey, Justin Gatwood, Adam Wiss, Kenneth Hohmeier, Steven R Erickson
PURPOSE: Results of a study to determine if disparities in drug pricing, pharmacy services, and community pharmacy access exist in a Tennessee county with a predominantly minority population are reported. METHODS: A cross-sectional survey of community pharmacies in Shelby County, a jurisdiction with a total population more than 60% composed of racial and ethnic minority groups, was conducted. Data collection included "out-of-pocket" (i.e., cash purchase) prices for generic levothyroxine, methylphenidate, and hydrocodone-acetaminophen; pharmacy hours of operation; availability of selected pharmacy services; and ZIP code-level data on demographics and crime risk...
April 4, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28375573/delayed-tsh-recovery-after-dose-adjustment-during-tsh-suppressive-levothyroxine-therapy-of-thyroid-cancer
#19
Hye In Kim, Tae Hyuk Kim, Hosu Kim, Young Nam Kim, Hye Won Jang, Jung-Han Kim, Kyu Yeon Hur, Jae Hoon Chung, Sun Wook Kim
BACKGROUND: Delayed thyroid-stimulating hormone (TSH) recovery during treatment of Graves' disease is caused by long-term excessive thyroid hormone, which results in down-regulation of pituitary thyrotropes. However, it is unknown whether delayed TSH recovery exists after levothyroxine (LT4) dose reduction in differentiated thyroid cancer (DTC) patients after long-term TSH suppression. METHODS: We retrospectively reviewed 97 DTC patients with LT4 dose reduction after long-term TSH suppression...
April 4, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28358714/effects-of-l-thyroxine-treatment-on-heart-functions-in-infants-with-congenital-hypothyroidism
#20
Alev Arslan, Veysel Nijat Baş, Salih Uytun, Hatice Gamze Poyrazoğlu
BACKGROUND: Impaired heart functions in newborns with hypothyroidism should be reversed by levothyroxine substitution therapy. The aim of the study was to investigate heart functions with congenital hypothroidism (CH) in newborns and changes after levothyroxine substitution therapy, measured with tissue Doppler echocardiography and conventional echocardiography. METHODS: The study included 30 neonates with CH and 34 healthy controls. Echocardiography were performed at baseline, 2nd week and 6th month of therapy...
March 30, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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