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https://www.readbyqxmd.com/read/28336049/hypothyroidism
#1
REVIEW
Layal Chaker, Antonio C Bianco, Jacqueline Jonklaas, Robin P Peeters
Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors...
March 20, 2017: Lancet
https://www.readbyqxmd.com/read/28333677/y-site-physical-compatibility-of-beta-blocker-infusions-with-intensive-care-unit-admixtures
#2
Jaime A Foushee, Pmichaele Meredith, Laura M Fox, EdwardE Grace
Parenteral beta-blocker therapy via continuous infusion has shown promising results for improved outcomes for patients with septic shock. As patients with septic shock may require multiple intravenous medications, compatibility is necessary to co-infuse these medications through a y-site connector. The purpose of this study was to examine the physical compatibility of select intravenous drugs used for patients with septic shock combined with various intravenous beta-blockers including esmolol, labetalol, and metoprolol through a simulated y-site infusion...
July 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#3
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
STUDY QUESTION: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? SUMMARY ANSWER: TAI as such does not influence pregnancy outcome after IUI treatment. WHAT IS KNOWN ALREADY: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. STUDY DESIGN, SIZE, DURATION: This was a retrospective cohort study...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#4
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28326749/a-case-of-autoimmune-polyendocrine-syndrome-type-i-with-strong-positive-gad-antibody-titer-followed-up-with-glucose-tolerance-measured-by-oral-glucose-tolerance-test
#5
Rie Murakami, Toshihide Kawai, Shu Meguro, Matsuhiko Hayashi, Hiroshi Itoh
A 26-year-old Japanese woman presented with adrenal insufficiency, and treatment was started with cortisone and fludrocortisone in 1975. A few years later, she presented with hypoparathyroidism and was diagnosed with autoimmune polyendocrine syndrome type I (APS I), and treatment with calcium and alfacalcidol was started. She was found to have subacute thyroiditis and relative adrenal failure in 2006. Her condition remained stable under treatment with cortisone, fludrocortisone, levothyroxine, calcium lactate, precipitated calcium carbonate and alfacalcidol...
January 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28324131/case-report-fast-reversal-of-severe-osteoporosis-after-correction-of-excessive-levothyroxine-treatment-and-long-term-follow-up
#6
C M Laine, K Landin-Wilhelmsen
This case report describes a 38-year-old woman, who presented with bilateral femoral stress fractures and osteoporosis after years of excessive levothyroxine treatment. Her bone health was restored rapidly and long-lasting with the reduction of levothyroxine dosage. No bone-active treatment was warranted. INTRODUCTION: Hyperthyroidism is a known risk factor for osteoporosis and fractures. Recent studies on patients with serum thyrotropin-suppressive therapy have not, however, indicated adverse effects on bone during long-term follow-up...
March 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28324106/clinical-features-of-early-and-late-postoperative-hypothyroidism-after-lobectomy
#7
Suyeon Park, Min Ji Jeon, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, Tae Yong Kim, Suck Joon Hong, Young Kee Shong, Won Bae Kim, Tae-Yon Sung, Won Gu Kim
Context: Lobectomy is preferred in thyroid cancer to decrease surgical complications and avoid lifelong thyroid-hormone replacement. However, postoperative hypothyroidism, requiring thyroid-hormone replacement, may occur. Objective: We aimed to identify the incidence and risk factors of postoperative hypothyroidism to develop a surveillance strategy after lobectomy for papillary thyroid microcarcinoma (PTMC). Methods: This historical cohort study involved 335 PTMC patients treated by lobectomy...
January 11, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323629/effects-of-levothyroxine-on-pregnancy-outcomes-in-women-with-thyroid-dysfunction-a-meta-analysis-of-randomized-controlled-trials
#8
Jia Li, Jie Shen, Lan Qin
Context • Subclinical hypothyroidism (SCH) in pregnancy can be associated with increased complications in pregnant women and neurocognitive deficits in fetuses. Two recently published meta-analyses investigated the effects of levothyroxine (LT4) supplementation on pregnancy outcomes but did not report adverse complications and neonatal outcomes. Objectives • The study intended to assess the effects of LT4 supplementation in the treatment of pregnant women with thyroid dysfunction. Design • The research team performed a meta-analysis of randomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Chinese BioMedical Literature Service System, and China National Knowledge Infrastructure databases...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28323379/effects-of-short-term-levothyroxine-therapy-on-myocardial-injuries-in-patients-with-severe-overt-hypothyroidism-evidence-from-a-cardiac-mri-study
#9
Xia Gao, Zhe Chen, Min Liu, Yu-Mei Jia, Ning Yang, Zhi Yao, Xiao-Meng Feng, Yuan Xu, Guang Wang
PURPOSE: To investigate using magnetic resonance imaging (MRI) myocardial injuries and cardiac function in patients with newly diagnosed severe primary overt hypothyroidism (HT) before and after achieving euthyroidism by short-term levothyroxine treatment. Levothyroxine treatment improves cardiovascular performance and ventricular remodeling in patients with HT, but diffuse myocardial injuries induced by HT are difficult to detect clinically. MATERIALS AND METHODS: Myocardial longitudinal relaxation time (T1 ) mapping using the modified Look-Locker inversion-recovery (MOLLI) sequences at 3...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28318881/targeted-therapy-in-thyroid-cancer-state-of-the-art
#10
L Valerio, L Pieruzzi, C Giani, L Agate, V Bottici, L Lorusso, V Cappagli, L Puleo, A Matrone, D Viola, C Romei, R Ciampi, E Molinaro, R Elisei
Thyroid cancer typically has a good outcome following standard treatments, which include surgery, radioactive iodine ablation for differentiated tumours and treatment with thyrotropine hormone-suppressive levothyroxine. Thyroid cancers that persist or recur following these therapies have a poorer prognosis. Cytotoxic chemotherapy or external beam radiotherapy has a low efficacy in these patients. 'Target therapy' with tyrosine kinase inhibitors (TKIs) represent an important therapeutic option for the treatment of advanced cases of radioiodine refractory (RAI-R) differentiated thyroid cancer (DTC), medullary thyroid cancer (MTC) and possibly for cases of poorly differentiated (PDTC) and anaplastic thyroid cancer (ATC)...
March 16, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28315909/a-concise-review-of-hashimoto-thyroiditis-ht-and-the-importance-of-iodine-selenium-vitamin-d-and-gluten-on-the-autoimmunity-and-dietary-management-of-ht-patients-points-that-need-more-investigation
#11
REVIEW
Michael I Liontiris, Elias E Mazokopakis
Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. The additional role of diet for the management of HT is usually overlooked...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315587/the-effect-of-l-thyroxine-treatment-on-sexual-function-and-depressive-symptoms-in-men-with-autoimmune-hypothyroidism
#12
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Thyroid autoimmunity and mild hypothyroidism in women seem to be associated with sexual dysfunction and depressive symptoms. Data concerning similar associations in men are limited. The aim of this study was to investigate sexual functioning and depressive symptoms in men with autoimmune hypothyroidism. METHODS: The study population consisted of three groups: men with autoimmune overt hypothyroidism (group A), men with autoimmune subclinical hypothyroidism (group B) and healthy euthyroid males without thyroid autoimmunity (group C)...
January 17, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28287838/renal-function-improves-with-the-treatment-of-hypothyroidism
#13
Oktay Bulur, Kursat Dal, Derun Taner Ertugrul, Murat Eser, Fatma Kaplan Efe, Serdar Karakaya, Kubilay Şahin, Salih Baser, Naim Ata, Aysun Aybal Kutlugun, Esin Beyan
BACKGROUND: It has been known that thyroid hormones may affect renal function. In this study, we aimed to investigate the effect of levothyroxine replacement on renal function in hypothyroid patients before and after treatment. METHODS: We retrospectively investigated free T3 (fT3), free T4 (fT4), TSH, creatinine, and eGFR measurements during both hypothyroid and euthyroid states of hypothyroid patients. The eGFR was calculated using the simplified Modification of Diet in Renal Disease formula...
March 13, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28280081/myxoedema-in-a-patient-with-achondroplasia-in-rural-area-of-guatemala
#14
Michel Juarez, Peter Rohloff
A 43-year-old indigenous Guatemalan woman with achondroplasia presented to our clinic with chronic fatigue and generalised oedema. She had limited contact with the formal healthcare system. However, 1 year prior, she had sought medical evaluation from a private physician. Her symptoms had been attributed to a combination of heart failure and physical disability due to the musculoskeletal complications of her achondroplasia. She was lost to follow-up due to inability to pay for further testing or treatment...
March 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28260699/is-thyroid-autoimmunity-itself-associated-with-psychological-well-being-in-euthyroid-hashimoto-s-thyroiditis
#15
Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Burcak Cavnar, Basak Bolayir, Mujde Akturk, Emre Arslan, Cigdem Ozkan, Nuri Cakir, Fusun Balos Toruner
Recent studies imply that euthyroid Hashimoto's thyroiditis (HT) might be related with impaired HRQoL, depression and anxiety. Ninety three patients with euthyroid HT and 31 age- and gender-matched euthyroid control subjects were enrolled into this study. SF-36 questionnaire, Beck Depression Inventory and Beck Anxiety Inventory tests were used for evaluating HRQoL, depression and anxiety. Beck Depression Inventory scores were higher in patients with HT compared to control subjects (7.5 (4.0-14.75) vs. 5.0 (2...
March 4, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28260180/sleeve-gastrectomy-leads-to-easy-management-of-hormone-replacement-therapy-and-good-weight-loss-in-patients-treated-for-craniopharyngioma
#16
Manuela Trotta, Joël Da Broi, Angelo Salerno, Rosa M Testa, Giuseppe M Marinari
The aim of this study is to investigate the effects of sleeve gastrectomy on hormone replacement therapy and on hypothalamic obesity in patients affected by craniopharyngioma with post-surgical pan-hypopituitarism. A retrospective review of three patients, treated for hypothalamic obesity with laparoscopic sleeve gastrectomy, who have previously undergone surgery for craniopharyngioma in their childhood, was done. Patients' mean age and BMI were 22.3 years (range 21-24) and 49.2 kg/m(2) (range 41.6-58.1), respectively...
March 4, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28259872/characterization-of-thyroid-abnormalities-in-a-large-cohort-of-children-with-down-syndrome%C3%A2
#17
Melinda J Pierce, Stephen H LaFranchi, Joseph D Pinter
BACKGROUND/AIMS: Thyroid disease is a common comorbidity in individuals with Down syndrome (DS), but historical studies have multiple limitations. We assessed thyroid abnormalities in a large cohort of children with DS. METHODS: Retrospective records review from a single institution. Calculated prevalence of common thyroid abnormalities and associations with common comorbidities. RESULTS: Among 508 patients, 120 (24%) had a thyroid-related diagnosis, the majority having elevated thyrotropin treated with levothyroxine...
March 3, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28258491/stimulated-thyroglobulin-values-above-5-6%C3%A2-ng-ml-before-radioactive-iodine-ablation-treatment-following-levothyroxine-withdrawal-is-associated-with-a-2-38-fold-risk-of-relapse-in-tg-ab-negative-subjects-with-differentiated-thyroid-cancer
#18
U Mousa, A S Yilmaz, A Nar
BACKGROUND: Serum thyroglobulin (Tg) is the key parameter used in the follow-up of subjects with differentiated thyroid cancer (DTC). Current guidelines advise its measurement to take place when Thyrotropin (TSH) levels are >30 µU/ml (stimulated Tg) and when TSH < 0.1 µU/ml (suppressed Tg). Although stimulated Tg levels <1 ng/ml have been shown to display excellent prognosis, relapses may occur despite low Tg levels. Recently, very low cut-off levels of stimulated Tg have been proposed for determining the recurrence risk in these subjects...
March 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28250299/successful-pregnancies-and-deliveries-in-a-patient-with-evolving-hypopituitarism-due-to-pituitary-stalk-transection-syndrome-role-of-growth-hormone-replacement
#19
Miyako Yoshizawa, Yasuhiko Ieki, Eisuke Takazakura, Kaori Fukuta, Takao Hidaka, Takanobu Wakasugi, Akira Shimatsu
We herein report a 31-year-old Japanese woman with evolving hypopituitarism due to pituitary stalk transection syndrome. She had a history of short stature treated with growth hormone (GH) in childhood and had hypothyroidism and primary amenorrhea at 20 years old. Levothyroxine replacement and recombinant follicle stimulating hormone-human chorionic gonadotropin (FSH-hCG) therapy for ovulation induction were started. GH replacement therapy (GHRT) was resumed when she was 26 years old. She developed mild adrenocortical insufficiency at 31 years old...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28249936/subclinical-hypothyroidism-to-treat-or-not-to-treat-a-systematic-review-with-meta-analysis-on-lipid-profile
#20
Isabel Abreu, Eva Lau, Bernardo Sousa-Pinto, Davide Carvalho
Previous studies suggested that subclinical hypothyroidism has a detrimental effect on cardiovascular risk factors, and that its effective treatment may have a beneficial impact on overall health. The main purpose of this review and meta-analysis was to assess whether subclinical hypothyroidism treatment is of clinical relevance, based on cardiovascular risk parameters correction. A systemic research of the literature using MEDLINE tool was performed to identify the relevant studies. Only placebo-controlled randomized control trials were included...
March 1, 2017: Endocrine Connections
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