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Lactate AND Diabetes

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https://www.readbyqxmd.com/read/28092089/time-dependent-lactate-production-and-amino-acid-utilization-in-cultured-astrocytes-under-high-glucose-exposure
#1
Dan Wang, Liangcai Zhao, Hong Zheng, Minjian Dong, Linlin Pan, Xi Zhang, Huajie Zhang, Hongchang Gao
Accumulating investigations have focused on the severity of central nervous system (CNS) complications in diabetic patients. The effects of the high glucose (HG) probably attribute to the metabolic disturbances in CNS. Astrocytes, with powerful ability of metabolic regulation, play crucial roles in physiological and pathological processes in CNS. Hence, an in-depth analysis as to metabolic alterations of astrocytes exposure to HG would facilitate to explore the underlying pathogenesis. In this study, the (1)H NMR-based metabonomic approach was performed to characterize the metabolic variations of intracellular metabolites and corresponding culture media in a time-dependent manner...
January 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28089584/pterostilbene-attenuates-high-glucose-induced-oxidative-injury-in-hippocampal-neuronal-cells-by-activating-nuclear-factor-erythroid-2-related-factor-2
#2
Yang Yang, Chongxi Fan, Bodong Wang, Zhiqiang Ma, Dongjin Wang, Bing Gong, Shouyin Di, Shuai Jiang, Yue Li, Tian Li, Zhi Yang, Erping Luo
In the present study, neuroblastoma (SH-SY5Y) cells were used to investigate the mechanisms mediating the potential protective effects of pterostilbene (PTE) against mitochondrial metabolic impairment and oxidative stress induced by hyperglycemia for mimicking the diabetic encephalopathy. High glucose medium (100 mM) decreased cellular viability after 24 h incubation which was evidenced by: (i) reduced mitochondrial complex I and III activities; (ii) reduced mitochondrial cytochrome C; (iii) increased reactive oxygen species (ROS) generation; (iv) decreased mitochondrial membrane potential (ΔΨm); and (v) increased lactate dehydrogenase (LDH) levels...
January 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28088662/metabolic-profiles-of-exudates-from-chronic-leg-ulcerations
#3
Adam Junka, Wojciech Wojtowicz, Adam Ząbek, Grzegorz Krasowski, Danuta Smutnicka, Barbara Bakalorz, Agnieszka Boruta, Mariusz Dziadas, Piotr Młynarz, Parish Paymon Sedghizadeh, Marzenna Bartoszewicz
Chronic leg ulceration is a disease usually associated with other comorbidities, and significantly reduces patient quality of life. Infected leg ulcers can lead to limb-threatening sequelae or mortality. Leg ulcerations are colonized by a number of microbes that are able to cause life-threating infections in susceptible patients. Wound exudate is a body fluid that collects metabolites from patient eukaryotic cells and from prokaryotic bacterial communities inhabiting the wound. This study aimed at identification of metabolites in exudates collected from chronic leg ulcers, and correlation of this metabolome with patient comorbidities and microbiological status of the wound...
January 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28078246/the-effects-of-crocin-insulin-and-their-co-administration-on-the-heart-function-and-pathology-in-streptozotocin-induced-diabetic-rats
#4
Amir Abbas Farshid, Esmaeal Tamaddonfard, Masoumeh Moradi-Arzeloo, Navideh Mirzakhani
OBJECTIVE: Crocin is a saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. MATERIALS AND METHODS: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), subcutaneous (s.c.) injection of insulin (4 IU/kg) and their combination were administered for eight weeks...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28072911/potential-protective-effect-of-lactation-against-incidence-of-type-2-diabetes-in-women-with-previous-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#5
REVIEW
Kanako Tanase-Nakao, Naoko Arata, Maki Kawasaki, Ichiro Yasuhi, Hirohito Sone, Rintaro Mori, Erika Ota
BACKGROUND: Lactation may protect women with previous gestational diabetes mellitus (GDM) from developing type 2 diabetes, but the results of existing studies are inconsistent, ranging from null to beneficial. We aimed to conduct a systematic review to gather available evidence. METHODS: Databases MEDLINE, CINAHL, PubMed and EMBASE were searched on 15 December 2015 without restriction of language or publication year. A manual search was also conducted. We included observational studies (cross-sectional, case-control and cohort study) with information on lactation and type 2 diabetes incidence among women with previous GDM...
January 10, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28072825/dietary-chromium-restriction-of-pregnant-mice-changes-the-methylation-status-of-hepatic-genes-involved-with-insulin-signaling-in-adult-male-offspring
#6
Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wang
Maternal undernutrition is linked with an elevated risk of diabetes mellitus in offspring regardless of the postnatal dietary status. This is also found in maternal micro-nutrition deficiency, especial chromium which is a key glucose regulator. We investigated whether maternal chromium restriction contributes to the development of diabetes in offspring by affecting DNA methylation status in liver tissue. After being mated with control males, female weanling 8-week-old C57BL mice were fed a control diet (CON, 1...
2017: PloS One
https://www.readbyqxmd.com/read/28070703/nmr-based-metabolomics-reveals-brain-region-specific-metabolic-alterations-in-streptozotocin-induced-diabetic-rats-with-cognitive-dysfunction
#7
Hong Zheng, Qiuting Lin, Dan Wang, Pengtao Xu, Liangcai Zhao, Wenyi Hu, Guanghui Bai, Zhihan Yan, Hongchang Gao
Diabetes mellitus (DM) can result in cognitive dysfunction, but its potential metabolic mechanisms remain unclear. In the present study, we analyzed the metabolite profiling in eight different brain regions of the normal rats and the streptozotocin (STZ)-induced diabetic rats accompanied by cognitive dysfunction using a (1)H NMR-based metabolomic approach. A mixed linear model analysis was performed to assess the effects of DM, brain region and their interaction on metabolic changes. We found that different brain regions in rats displayed significant metabolic differences...
January 9, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28069660/antioxidant-treatment-attenuates-lactate-production-in-diabetic-nephropathy
#8
Christoffer Laustsen, Per Mose Nielsen, Thomas Stokholm Nørlinger, Haiyun Qi, Uffe Kjærgaard Pedersen, Lotte Bonde Bertelsen, Jakob Appel Østergaard, Allan Flyvbjerg, Jan Henrik Ardenkjær-Larsen, Fredrik Palm, Hans Stødkilde-Jørgensen
The early progression of diabetic nephropathy is notoriously difficult to detect and quantify before the occurrence of substantial histological damage. Recently, hyperpolarized [1-(13)C]pyruvate has demonstrated increased lactate production in the kidney early after the onset of diabetes, implying increased lactate dehydrogenase activity as a consequence of increased nicotinamide adenine dinucleotide substrate availability due to upregulation of the polyol pathway, i.e., pseudohypoxia. In this study, we investigated the role of oxidative stress in mediating these metabolic alterations using state-of-the-art hyperpolarized magnetic resonance (MR) imaging...
January 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28068681/hypoxia-and-hyperoxia-affect-serum-angiogenic-regulators-in-t2dm-men-during-cycling
#9
C Brinkmann, A Metten, P Scriba, C V M Tagarakis, P Wahl, J Latsch, K Brixius, W Bloch
Exercise-induced transient increases in pro-angiogenic regulators can promote angiogenesis.This pilot study aims to analyze the potential of exercise to positively affect angiogenic regulators in patients with type 2 diabetes mellitus (T2DM), who often exhibit abnormal angiogenesis, under different environmental conditions. 9 overweight/obese men with uncomplicated T2DM (8 took anti-diabetic drugs) performed submaximal cycling for 40 min in normoxia (≈21 vol%O2), hypoxia (≈14 vol%O2) and during alternating hypoxia/hyperoxia (≈14 vol%O2/≈30 vol%O2, 5-min intervals) (3×3 crossover design)...
January 9, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28039838/fibroblast-growth-factor-21-and-its-novel-association-with-oxidative-stress
#10
REVIEW
Miguel Ángel Gómez-Sámano, Mariana Grajales-Gómez, Julia María Zuarth-Vázquez, Ma Fernanda Navarro-Flores, Mayela Martínez-Saavedra, Óscar Alfredo Juárez-León, Mariana G Morales-García, Víctor Manuel Enríquez-Estrada, Francisco J Gómez-Pérez, Daniel Cuevas-Ramos
Fibroblast growth factor 21 (FGF21) is an endocrine-member of the FGF family. It is synthesized mainly in the liver, but it is also expressed in adipose tissue, skeletal muscle, and many other organs. It has a key role in glucose and lipid metabolism, as well as in energy balance. FGF21 concentration in plasma is increased in patients with obesity, insulin resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. Different types of physical stress, such as strenuous exercising, lactation, diabetic nephropathy, cardiovascular disease, and critical illnesses, also increase FGF21 circulating concentration...
December 22, 2016: Redox Biology
https://www.readbyqxmd.com/read/28027536/effects-of-a-standardized-extract-of-rheum-turkestanicum-janischew-root-on-diabetic-changes-in-the-kidney-liver-and-heart-of-streptozotocin-induced-diabetic-rats
#11
Azar Hosseini, Hamid Mollazadeh, Mohammad Sadegh Amiri, Hamid Reza Sadeghnia, Ahmad Ghorbani
Numerus studies highlighted benefits of natural flavonoids in the management of diabetes. The present study was aimed to investigate the effects of a high flavonoids containing extract of Rheum turkestanicum on diabetic changes in different tissues. Male Wistar rats were divided into normal and streptozotocin-induced diabetic groups received saline or hydroalcoholic extract of R. turkestanicum root (100, 200 and 300mg/kg) through orogastric gavage for 4 weeks. Serum glucose, HbA1c, lipids, creatinine, uric acid, liver enzymes (alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase), and cardiac enzymes (lactate dehydrogenase and creatine phosphokinase) in diabetic control group were significantly higher compared to normal control group (p<0...
December 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28009330/failure-to-initiate-breastfeeding-among-high-risk-obstetrical-patients-who-intended-to-breastfeed
#12
L Cordero, R Oza-Frank, M Moore-Clingenpeel, M B Landon, C A Nankervis
BACKGROUND: In the US, at the time of discharge from the hospital, 79% of women had initiated breastfeeding. Intention to breastfeed is a strong predictor of breastfeeding initiation; however, we reported initiation failure in 45% of women with pregestational diabetes who intended to breastfeed. Information regarding intention and initiation among women with other high risk obstetrical conditions (HROB) remains scarce. OBJECTIVE: To ascertain demographic and clinical factors associated with breastfeeding initiation failure among women with HROB conditions who intended to breastfeed...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28002466/assessment-of-the-role-of-metabolic-determinants-on-the-relationship-between-insulin-sensitivity-and-secretion
#13
Jose E Galgani, Carmen Gómez, Maria L Mizgier, Juan Gutierrez, Jose L Santos, Pablo Olmos, Andrea Mari
BACKGROUND: Insulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas. Such interaction might be mediated through glucose oxidation that may drive the release of circulating factors with action on insulin secretion. AIM: To evaluate the association between whole-body carbohydrate oxidation and circulating factors with insulin secretion to consecutive oral glucose loading in non-diabetic individuals...
2016: PloS One
https://www.readbyqxmd.com/read/27987117/differential-effects-of-type-2-diabetes-on-brain-glycometabolism-in-rats-focus-on-glycogen-and-monocarboxylate-transporter-2
#14
Takeru Shima, Subrina Jesmin, Takashi Matsui, Mariko Soya, Hideaki Soya
Astrocyte-neuron lactate shuttle (ANLS) is a pathway that supplies glycogen-derived lactate to active neurons via monocarboxylate transporter 2 (MCT2), and is important for maintaining brain functions. Our study revealed alterations of ANLS with hippocampal hyper-glycogen levels and downregulated MCT2 protein levels underlying hippocampal dysfunctions as a complication in type 2 diabetic (T2DM) animals. Since T2DM rats exhibit brain dysfunctions involving several brain regions, we examined whether there might also be T2DM effects on ANLS's disturbances in other brain loci...
December 16, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27981898/the-role-of-carbonic-anhydrase-in-hepatic-glucose-production
#15
Ibrahim Salihu Ismail
Considerable efforts are being made daily to discover novel therapeutic targets to better understand the mechanism for designing drugs in treating diabetes. Inhibition of hepatic gluconeogenesis by metformin remains the first line of oral therapy for managing type 2 diabetes. The link between rise in blood lactate level and reduction of hepatic glucose production with metformin usage remains to be determined. Carbonic anhydrase is proposed to be the link connecting blood lactate accumulation and inhibition of hepatic gluconeogenesis and thus could serve as a new therapeutic target for reducing hepatic glucose production...
December 14, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27975067/hyperlactatemia-and-the-outcome-of-type-2-diabetic-patients-suffering-acute-myocardial-infarction
#16
Jovanovic Aleksandar, Peric Vladan, Snezana Markovic-Jovanovic, Radojica Stolic, Jadranka Mitic, Tanja Smilic
Background. Increased lactate production is frequent in unregulated/complicated diabetes mellitus. Methods. Three groups, each consisting of 40 patients (type 2 diabetics with myocardial infarction, DM+AMI, nondiabetics suffering myocardial infarction, MI, and diabetics with no apparent cardiovascular pathology, DM group), were tested for pH, serum bicarbonate and electrolytes, blood lactate, and CK-MB. Results. Blood lactate levels were markedly higher in AMI+DM compared to MI group (4.54 ± 1.44 versus 3...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27965206/prior-lactation-reduces-future-diabetic-risk-through-sustained-post-weaning-effects-on-insulin-sensitivity
#17
Harpreet Bajaj, Chang Ye, Anthony J Hanley, Phil W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
Breastfeeding ≥12 months is recommended for optimal infant nutrition but may hold maternal benefits, as well. Indeed, lactation has been associated with lower long-term risk of diabetes in the mother but the mechanism by which it imparts sustained post-weaning effects on glucose tolerance remains unclear. In this context, we postulated that lactation potentially could induce post-weaning beneficial effects on glucose tolerance by modifying the natural history of insulin sensitivity and/or pancreatic beta-cell function over time...
December 13, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27928614/moderate-exercise-ameliorates-dysregulated-hippocampal-glycometabolism-and-memory-function-in-a-rat-model-of-type-2-diabetes
#18
Takeru Shima, Takashi Matsui, Subrina Jesmin, Masahiro Okamoto, Mariko Soya, Koshiro Inoue, Yu-Fan Liu, Ignacio Torres-Aleman, Bruce S McEwen, Hideaki Soya
AIMS/HYPOTHESIS: Type 2 diabetes is likely to be an independent risk factor for hippocampal-based memory dysfunction, although this complication has yet to be investigated in detail. As dysregulated glycometabolism in peripheral tissues is a key symptom of type 2 diabetes, it is hypothesised that diabetes-mediated memory dysfunction is also caused by hippocampal glycometabolic dysfunction. If so, such dysfunction should also be ameliorated with moderate exercise by normalising hippocampal glycometabolism, since 4 weeks of moderate exercise enhances memory function and local hippocampal glycogen levels in normal animals...
December 8, 2016: Diabetologia
https://www.readbyqxmd.com/read/27898282/comparative-fingerprinting-of-the-human-microbiota-in-diabetes-and-cardiovascular-disease
#19
Emanuel Vamanu, Diana Pelinescu, Ionela Sarbu
Diabetes and cardiovascular diseases are major causes of morbidity and mortality worldwide, and are associated with changes in the human gut microbiota. To better understand the relationships between diet, disease, and the colonic microbiome, we used the in vitro GIS1 system and repetitive element palindromic polymerase chain reaction (rep-PCR) to determine the microbial fingerprints in individuals with these diseases and compared them with the fingerprints in healthy controls. Clear differences were apparent in the three groups...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27897443/evaluation-of-biochemical-composition-of-vitreous-of-eyes-of-diabetic-patients-using-proton-magnetic-resonance-spectroscopy
#20
Ilke Bahceci Simsek, Ozgur Artunay
PURPOSE: To investigate possible metabolic changes in vitreous of patients with diabetes mellitus with or without diabetic retinopathy using proton magnetic resonance spectroscopy. MATERIAL AND METHODS: Twenty-eight healthy control subjects (group 1), 18 patients with diabetes mellitus without diabetic retinopathy (group 2) and 18 patients with diabetic retinopathy (group 3) were included. Proton magnetic resonance spectroscopy was performed in left vitreous of all subjects; amounts of Glutamate, Choline, Lactate and Creatine values were measured...
November 29, 2016: Current Eye Research
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