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https://www.readbyqxmd.com/read/29021846/the-influence-of-residual-apixaban-on-bleeding-complications-during-and-after-catheter-ablation-of-atrial-fibrillation
#1
Yutaro Mukai, Kyoichi Wada, Koji Miyamoto, Kazuki Nakagita, Mai Fujimoto, Kouichi Hosomi, Takeshi Kuwahara, Mitsutaka Takada, Kengo Kusano, Akira Oita
BACKGROUND: The periprocedural protocol for atrial fibrillation (AF) ablation commonly includes anticoagulation therapy. Apixaban, a direct oral anticoagulant, is currently approved for clinical use; however, little is known about the effects of residual apixaban concentration on bleeding complications during/after AF ablation. Therefore, we measured residual apixaban concentration by using mass spectrometry and examined the anticoagulant's residual effects on bleeding complications. METHODS: Fifty-eight patients (Mean age of 64...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28970024/clinical-decision-support-increases-diagnostic-yield-of-computed-tomography-for-suspected-pulmonary-embolism
#2
Angela M Mills, Ivan K Ip, Curtis P Langlotz, Ali S Raja, Hanna M Zafar, Ramin Khorasani
OBJECTIVE: Determine effects of evidence-based clinical decision support (CDS) on the use and yield of computed tomographic pulmonary angiography for suspected pulmonary embolism (CTPE) in Emergency Department (ED) patients. METHODS: This multi-site prospective quality improvement intervention conducted in three urban EDs used a pre/post design. For ED patients aged 18+years with suspected PE, CTPE use and yield were compared 19months pre- and 32months post-implementation of CDS intervention based on the Wells criteria, provided at the time of CTPE order, deployed in April 2012...
September 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28462696/hybrid-docking-qsar-studies-of-1-4-dihydropyridine-3-5-dicarboxamides-as-potential-antitubercular-agents
#3
Yasaman Rasouli, Asghar Davood
BACKGROUND: Tuberculosis is one of the main medical problems that some people are suffering still from this infectious disease. 1, 4-dihydropyridines are a multi-target ligands that recently are recognized as an anti-tubercular agents. METHOD: In the current research we did computational studies of some synthesized 1, 4-dihydropyridine-3, 5-dicarboxamides in non-hydrolyzed and hydrolyzed forms to find the drug-receptor interactions profile. RESULTS: Among equations that obtained for non-hydrolyzed compounds, the model with better statistical parameters such as R2= 0...
April 26, 2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/27853777/synthesis-structure-and-properties-of-new-bimetallic-sodium-and-potassium-lanthanum-borohydrides
#4
SeyedHosein Payandeh GharibDoust, Michael Heere, Magnus H Sørby, Morten B Ley, Dorthe B Ravnsbæk, Bjørn C Hauback, Radovan Černý, Torben R Jensen
Two new bimetallic sodium or potassium lanthanum borohydrides, NaLa(BH4)4 and K3La(BH4)6, are formed using La(BH4)3 free of metal halide by-products. NaLa(BH4)4 crystallizes in an orthorhombic crystal system with unit cell parameters, a = 6.7987(19), b = 17.311(5), c = 7.2653(19) Å and space group symmetry Pbcn. This compound has a new structure type built from brucite-like layers of octahedra (hcp packing of anions) with half of the octahedral sites empty leading to octahedral chains similar to rutile (straight chains) or α-PbO2 (zig-zag chains)...
November 17, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27709449/human-chorionic-gonadotropin-hcg-concentrations-during-the-late-first-trimester-are-associated-with-fetal-growth-in-a-fetal-sex-specific-manner
#5
Mirjana Barjaktarovic, Tim I M Korevaar, Vincent W V Jaddoe, Yolanda B de Rijke, Theo J Visser, Robin P Peeters, Eric A P Steegers
Human chorionic gonadotropin (hCG) is a pregnancy-specific hormone that regulates placental development. hCG concentrations vary widely throughout gestation and differ based on fetal sex. Abnormal hCG concentrations are associated with adverse pregnancy outcomes including fetal growth restriction. We studied the association of hCG concentrations with fetal growth and birth weight. In addition, we investigated effect modification by gestational age of hCG measurement and fetal sex. Total serum hCG (median 14...
February 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27703748/hospital-treatment-mortality-and-healthcare-costs-in-relation-to-socioeconomic-status-among-people-with-bipolar-affective-disorder
#6
Yi-Ju Pan, Ling-Ling Yeh, Yu-Chun Chen, Kuei-Hong Kuo, Chin-Kuo Chang
BACKGROUND: Evidence regarding the relationships between the socioeconomic status and long-term outcomes of individuals with bipolar affective disorder (BPD) is lacking. AIMS: We aimed to estimate the effects of baseline socioeconomic status on longitudinal outcomes. METHOD: A national cohort of adult participants with newly diagnosed BPD was identified in 2008. The effects of personal and household socioeconomic status were explored on outcomes of hospital treatment, mortality and healthcare costs, over a 3-year follow-up period (2008-2011)...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27383889/olive-leaf-extract-activity-against-candida-albicans-and-c-dubliniensis-the-in-vitro-viability-study
#7
Nataša Zorić, Nevenka Kopjar, Klara Kraljić, Nada Oršolić, Siniša Tomić, Ivan Kosalec
Olive leaf extract is characterized by a high content of polyphenols (oleuropein, hydroxytyrosol and their derivatives), which is associated with its therapeutic properties. The objective of the present research was to evaluate the antifungal activity of olive leaf extract against Candida albicans ATCC 10231 and C. dubliniensis CBS 7987 strains. Minimum inhibitory concentrations (MIC) of the extract were determined by several in vitro assays. The extract showed a concentration depended effect on the viability of C...
September 1, 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/27357196/estimated-association-between-dwelling-soil-contamination-and-internal-radiation-contamination-levels-after-the-2011-fukushima-daiichi-nuclear-accident-in-japan
#8
Masaharu Tsubokura, Shuhei Nomura, Kikugoro Sakaihara, Shigeaki Kato, Claire Leppold, Tomoyuki Furutani, Tomohiro Morita, Tomoyoshi Oikawa, Yukio Kanazawa
OBJECTIVES: Measurement of soil contamination levels has been considered a feasible method for dose estimation of internal radiation exposure following the Chernobyl disaster by means of aggregate transfer factors; however, it is still unclear whether the estimation of internal contamination based on soil contamination levels is universally valid or incident specific. METHODS: To address this issue, we evaluated relationships between in vivo and soil cesium-137 (Cs-137) contamination using data on internal contamination levels among Minamisoma (10-40 km north from the Fukushima Daiichi nuclear power plant), Fukushima residents 2-3 years following the disaster, and constructed three models for statistical analysis based on continuous and categorical (equal intervals and quantiles) soil contamination levels...
2016: BMJ Open
https://www.readbyqxmd.com/read/27090157/improved-outcomes-due-to-changes-in-organization-of-care-for-patients-with-ovarian-cancer-in-the-netherlands
#9
F A Eggink, C H Mom, R F Kruitwagen, A K Reyners, W J Van Driel, L F Massuger, G C Niemeijer, A G Van der Zee, M A Van der Aa, H W Nijman
OBJECTIVES: Objectives of this study were to evaluate the effect of changes in patterns of care, for example centralization and treatment sequence, on surgical outcome and survival in patients with epithelial ovarian cancer (EOC). METHODS: Patients diagnosed with FIGO stage IIB-IV EOC (2004-2013) were selected from the Netherlands Cancer Registry. Primary outcomes were surgical outcome (extent of macroscopic residual tumor after surgery) and overall survival. Changes in treatment sequence (primary debulking surgery and adjuvant chemotherapy (PDS+ACT) or neo-adjuvant chemotherapy and interval debulking surgery (NACT+IDS)), hospital type and annual hospital volume were also evaluated...
June 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27000783/impact-of-socioeconomic-deprivation-on-screening-for-cardiovascular-disease-risk-in-a-primary-prevention-population-a-cross-sectional-study
#10
Sarah-Jane Lang, Gary A Abel, Jonathan Mant, Ricky Mullis
OBJECTIVES: Investigate the association between socioeconomic deprivation and completeness of cardiovascular disease (CVD) risk factor recording in primary care, uptake of screening in people with incomplete risk factor recording and with actual CVD risk within the screened subgroup. DESIGN: Cross-sectional study. SETTING: Nine UK general practices. PARTICIPANTS: 7987 people aged 50-74 years with no CVD diagnosis. METHODS: CVD risk was estimated using the Framingham equation from data extracted from primary care electronic health records...
March 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/26875172/unintentional-injuries-treated-in-hospital-emergency-departments-among-persons-aged-65-years-and-older-united-states-2006-2011
#11
Xinyao DeGrauw, Joseph L Annest, Judy A Stevens, Likang Xu, Victor Coronado
INTRODUCTION: With the aging of the United States population, unintentional injuries among older adults, and especially falls-related injuries, are an increasing public health concern. METHODS: We analyzed emergency department (ED) data from the Nationwide Emergency Department Sample, 2006-2011. We examined unintentional injury trends by 5-year age groups, sex, mechanism, body region, discharge disposition, and primary payer. For 2011, we estimated the medical costs of unintentional injury and the distribution of primary payers, plus rates by injury mechanisms and body regions injured by 5-year age groups...
February 2016: Journal of Safety Research
https://www.readbyqxmd.com/read/26519637/prevalence-and-correlates-of-dsm-iv-tr-major-depressive-disorder-self-reported-diagnosed-depression-and-current-depressive-symptoms-among-adults-in-germany
#12
Ulrike E Maske, Amanda K Buttery, Katja Beesdo-Baum, Steffi Riedel-Heller, Ulfert Hapke, Markus A Busch
BACKGROUND: While standardized diagnostic interviews using established criteria are the gold standard for assessing depression, less time consuming measures of depression and depressive symptoms are commonly used in large population health surveys. We examine the prevalence and health-related correlates of three depression measures among adults aged 18-79 years in Germany. METHODS: Using cross-sectional data from the national German Health Interview and Examination Survey for Adults (DEGS1) (n=7987) and its mental health module (DEGS1-MH) (n=4483), we analysed prevalence and socio-demographic and health-related correlates of (a) major depressive disorder (MDD) established by Composite International Diagnostic Interview (CIDI) using DSM-IV-TR criteria (CIDI-MDD) in the last 12 months, (b) self-reported physician or psychotherapist diagnosed depression in the last 12 months, and (c) current depressive symptoms in the last two weeks (PHQ-9, score ≥10)...
January 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26406868/differential-expression-and-clinical-significance-of-serum-protein-among-patients-with-clear-cell-renal-cell-carcinoma
#13
Yiliyaer Nuerrula, Mulati Rexiati, Qiang Liu, Yu-Jie Wang
BACKGROUND AND OBJECTIVE: Looking for tumor markers by using protein chip technology is one of the hot topics, but many studies are still limited on short term detection of differential expressed proteins before and after surgery among patients with RCC. This study analyzed differential expressed serum protein and its clinical significance with clear-cell renal cell carcinoma to further measurement of the rule of variable expressing. METHODS: Eighty-nine patients with clear-cell renal cell carcinoma who underwent surgery from November 2013 to 2014 and postoperatively confirmed by pathology were entered in RCC group, 100 healthy volunteers and patients without RCC who underwent medical examination in the same period were entered in control group...
2015: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/26200429/-prevalence-and-comorbidity-of-self-reported-diagnosis-of-burnout-syndrome-in-the-general-population-results-of-the-german-health-interview-and-examination-survey-for-adults-degs1
#14
Ulrike E Maske, Steffi G Riedel-Heller, Ingeburg Seiffert, Frank Jacobi, Ulfert Hapke
Objective: To determine the prevalence and comorbid mental disorders of self-reported diagnosis of burnout syndrome in the general population of Germany. Methods: In the German Health Interview and Examination Survey (DEGS1) self-reported diagnosis of a burnout syndrome made by a physician or psychotherapist was assessed in a standardized interview (N = 7987). For N = 4483 mental disorders were determined with the Composite International Diagnostic Interview (CIDI). Weighted lifetime and 12-month prevalences were calculated...
January 2016: Psychiatrische Praxis
https://www.readbyqxmd.com/read/25158142/-prevalence-and-comorbidity-of-self-reported-diagnosis-of-burnout-syndrome-in-the-general-population
#15
Ulrike E Maske, Steffi G Riedel-Heller, Ingeburg Seiffert, Frank Jacobi, Ulfert Hapke
OBJECTIVE: To determine the prevalence and comorbid mental disorders of self-reported diagnosis of burnout syndrome in the general population of Germany. METHODS: In the German Health Interview and Examination Survey (DEGS1) self-reported diagnosis of a burnout syndrome made by a physician or psychotherapist was assessed in a standardized interview (N = 7987). For N = 4483 mental disorders were determined with the Composite International Diagnostic Interview (CIDI)...
January 2016: Psychiatrische Praxis
https://www.readbyqxmd.com/read/24571803/context-based-features-enhance-protein-secondary-structure-prediction-accuracy
#16
Ashraf Yaseen, Yaohang Li
We report a new approach of using statistical context-based scores as encoded features to train neural networks to achieve secondary structure prediction accuracy improvement. The context-based scores are pseudo-potentials derived by evaluating statistical, high-order inter-residue interactions, which estimate the favorability of a residue adopting certain secondary structure conformation within its amino acid environment. Encoding these context-based scores as important training and prediction features provides a way to address a long-standing difficulty in neural network-based secondary structure predictions of taking interdependency among secondary structures of neighboring residues into account...
March 24, 2014: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/24232149/patatin-a-major-soluble-protein-of-the-potato-solanum-tuberosum-l-tuber-is-synthesized-as-a-larger-precursor
#17
B Krischner, H Hahn
Antibodies were raised against the highly purified glycoprotein patatin. They were used to characterize the product synthesized in a wheatgerm cell-free translation system, programmed with polyadenylated RNA from potato tubers. Sodium dodecylsulfate-polyacrylamide gel electrophoresis revealed that the immunoprecipitated protein had a molecular mass of 43 kDa compared to 40 for the authentic patatin. It is assumed that patatin is synthesized in vivo as a larger precursor which is processed to the mature protein by cleavage of a signal peptide...
September 1986: Planta
https://www.readbyqxmd.com/read/23941164/genetic-variation-in-oxytocin-rs2740210-and-early-adversity-associated-with-postpartum-depression-and-breastfeeding-duration
#18
W Jonas, V Mileva-Seitz, A W Girard, R Bisceglia, J L Kennedy, M Sokolowski, M J Meaney, A S Fleming, M Steiner
Mothers vary in duration of breastfeeding. These individual differences are related to a variety of demographic and individual maternal factors including maternal hormones, mood and early experiences. However, little is known about the role of genetic factors. We studied single-nucleotide polymorphisms (SNPs) in the OXT peptide gene (rs2740210; rs4813627) and the OXT receptor gene (OXTR rs237885) in two samples of mothers from the Maternal adversity, Vulnerability and Neurodevelopment study (MAVAN), a multicenter (Hamilton and Montreal, Canada) study following mothers and their children from pregnancy until 7 years of age...
October 2013: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/23588906/the-natural-logarithm-transforms-the-abbreviated-injury-scale-and-improves-accuracy-scoring
#19
Xu Wang, Xiaoming Gu, Zhiliang Zhang, Fang Qiu, Keming Zhang
BACKGROUND: The Injury Severity Score (ISS) and the New Injury Severity Score (NISS) are widely used for anatomic severity assessments, but they do not display a linear relation to mortality. The mortality rates are significantly different between pairs of the Abbreviated Injury Scale (AIS) triplets that generate the same ISS/NISS total. METHODS: The Logarithm Injury Severity Score (LISS) is defined as a change in AIS values by raising each AIS severity score (1-6) by taking the natural logarithm to a power of 5...
November 2012: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/23220779/accounting-for-recent-trends-in-the-prevalence-of-diarrhoea-in-the-democratic-republic-of-congo-drc-results-from-consecutive-cross-sectional-surveys
#20
Jacques B O Emina, Ngianga-Bakwin Kandala
OBJECTIVES: To analyse trends in diarrhoea prevalence by maternal education, access to clean water and improved sanitation, household wealth index; to identify the sources of variation and assess contribution of changes in socioeconomic characteristics in the Democratic Republic of Congo (DRC). DESIGN: Consecutive cross-sectional surveys. SETTING: DRC. PARTICIPANTS: The databases contain information on 9748 children from the 2001 Multiple Indicators Cluster Survey and 7987 children from the 2007 Demographic and Health Survey...
2012: BMJ Open
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