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https://www.readbyqxmd.com/read/29156994/experimental-diabetes-impairs-maternal-reproductive-performance-in-pregnant-wistar-rats-and-their-offspring
#1
Leticia Bequer, Tahiry Gómez, José L Molina, Alain Álvarez, Claudia Chaviano, Sonia Clapés
The aim of this study was to determine the effect of mild hyperglycemia on metabolism during pregnancy, the maternal reproductive performance, and the characteristics of the offspring in neonatal mild diabetic-induced Wistar rats. The experimental diabetes model was generated by neonatal streptozotocin administration (100 mg of streptozotocin/Kg bw/sc) in female Wistar rats. At adulthood, the control and diabetic group were mated. At the 20th day of gestation, a maternal and fetal blood sample were collected for biochemical measurement...
November 20, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29150756/impact-of-risk-factors-for-gestational-diabetes-gdm-on-pregnancy-outcomes-in-women-with-gdm
#2
T Filardi, F Tavaglione, M Di Stasio, V Fazio, A Lenzi, S Morano
PURPOSE: In this study, we evaluated the impact of risk factors for gestational diabetes on clinical/biochemical parameters and maternal/fetal outcomes. METHODS: One hundred eighty-three (n 183) women (age 33.8 ± 5.5 years, 59% Caucasians, 41% non-Caucasians) with gestational diabetes were included in the study. Anamnestic information, anthropometric and laboratory parameters, and maternal and fetal outcomes at delivery were collected. RESULTS: Insulin therapy prevalence was higher in Asians vs Caucasians (p = 0...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29124047/adiponectin-concentration-in-gestational-diabetic-women-a-case-control-study
#3
Tanin Mohammadi, Zamzam Paknahad
Gestational diabetes mellitus (GDM) is an impaired fasting glucose condition during pregnancy. Adiponectin is a polypeptide hormone that is extensively released by adipocytes which regulates energy homeostasis and carbohydrate and lipid metabolism. In addition, adiponectin has antidiabetic and anti-inflammatory properties. The aim of our research was to study about the relationship of adiponectin levels to GDM and glucose intolerance. We selected 25 GDM women and 35 healthy pregnant subjects (18-46 years) who were screened between 24 and 28 weeks of gestation based on the result of oral glucose tolerance test (OGTT)...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29112786/circulating-b-type-natriuretic-peptide-in-women-with-and-without-recent-gestational-diabetes-the-impact-of-current-glucose-intolerance
#4
Leanne R De Souza, Chang Ye, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
CONTEXT: Circulating B-type natriuretic peptide, as measured by the N-terminal fragment of its prohormone (NT-proBNP), is inversely associated with incident type 2 diabetes (T2DM) but positively related to future cardiovascular disease (CVD). Recognizing that gestational diabetes (GDM) identifies women at future risk for both T2DM and CVD, we sought to determine whether gestational glucose tolerance relates to NT-proBNP in the years after delivery. DESIGN/PATIENTS/MEASUREMENTS: Three-hundred-and-forty women underwent a glucose challenge test (GCT) and an oral glucose tolerance test (OGTT) in pregnancy, yielding 4 gestational glucose tolerance groups: GDM (n=105); gestational impaired glucose tolerance (n=59); abnormal GCT with a normal OGTT (n=98); and normal GCT with normal OGTT (n=75)...
November 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29098391/fetal-sex-influences-maternal-fasting-plasma-glucose-levels-and-basal-%C3%AE-cell-function-in-pregnant-women-with-normal-glucose-tolerance
#5
Xinqian Geng, Lulu Geng, Yinan Zhang, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Minfang Tao, Congrong Wang, Weiping Jia
AIMS: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. METHODS: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29078256/predicting-persistent-impaired-glucose-tolerance-in-gdm-women-the-role-of-hscrp-and-adiponectin
#6
Celeste P Durnwald, Katheryne Downes, Rita Leite, Michal Elovitz, Samuel Parry
BACKGROUND: To evaluate whether maternal serum adiponectin and high-sensitivity C-reactive protein (hsCRP) levels at the time of gestational diabetes (GDM) diagnosis are associated with persistent glucose intolerance in GDM women at 6-12 weeks postpartum. METHODS: This is a secondary analysis of prospective randomized trial of GDM women enrolled in a behavior education program. Women with a GDM diagnosis ≥ 20 weeks were included. At the time of randomization, serum adiponectin and hsCRP levels were drawn...
October 27, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29064082/abnormal-1-hour-post-load-glycemia-during-pregnancy-impairs-post-partum-metabolic-status-a-single-center-experience
#7
A Tumminia, A Milluzzo, F Cinti, M Parisi, F Tata, F Frasca, L Frittitta, R Vigneri, L Sciacca
PURPOSE: Recent evidence indicates that people with normal glucose tolerance (NGT) but 1-h post-load plasma glucose (1-h OGTT) ≥ 155 mg/dl have an increased risk for developing Type 2 diabetes mellitus (T2DM), determining a new risk category with deeper metabolic impairment. The aim of this study was to identify, among women with gestational diabetes (GDM), which alterations at OGTT during pregnancy are more frequently associated with 1-h OGTT ≥ 155 mg/dl at post-partum examination...
October 24, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29058058/maternal-early-pregnancy-plasma-concentration-of-25-hydroxyvitamin-d-and-risk-of-gestational-diabetes-mellitus
#8
Changen Xu, He-Hong Ma, Yao Wang
We examined whether 25-Hydroxyvitamin D [25(OH) D] concentrations, measured at the first prenatal visit, would be associated with risk of gestational diabetes mellitus (GDM). From July 2015 to June 2016, consecutive women who admitted to the two-obstetrics center in china were included. Relevant data were collected between 24 and 28 weeks of gestation, including fasting plasma glucose (FPG) and 25(OH) D concentrations at the first prenatal visit and the one-step GDM screened with 75-g oral glucose tolerance test (OGTT)...
October 22, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29028674/urinary-bisphenol-a-concentration-and-gestational-diabetes-mellitus-in-chinese-women
#9
Xia Wang, Xu Wang, Qian Chen, Zhong-Cheng Luo, Shasha Zhao, Weiye Wang, Hui-Juan Zhang, Jun Zhang, Fengxiu Ouyang
BACKGROUND: Bisphenol A (BPA) has been associated with variable metabolic effects in animal models. It is unknown whether BPA exposure affects glucose tolerance in pregnancy. We aimed to investigate whether maternal urinary BPA concentration is associated with gestational diabetes mellitus (GDM). METHODS: This study included 620 pregnant women from Shanghai, China 2012-2013. Maternal urinary BPA concentration was measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28977166/long-term-follow-up-of-patients-with-elevated-igf-1-and-nadir-gh-0-4-%C3%A2%C2%B5g-l-but-1-%C3%A2%C2%B5g-l
#10
Pedro Weslley Rosario, Maria Regina Calsolari
OBJECTIVE: To report the results of initial investigation and after 5 years of patients with a suspicious clinical scenario for acromegaly, elevated IGF-1, and nadir GH during an oral glucose tolerance test (OGTT) > 0.4 µg/L but < 1 µg/L. SUBJECTS AND METHODS: Seventeen patients who had elevated IGF-1 (outside puberty and pregnancy) in two measurements and GH between 0.4 and 1 µg/L during OGTT were selected. RESULTS: During initial assessment, only one patient had microadenoma on magnetic resonance imaging (MRI) of the pituitary...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28939944/gestational-retinal-microvasculature-and-the-risk-of-5%C3%A2-year-postpartum-abnormal-glucose-metabolism
#11
Ling-Jun Li, Kok Hian Tan, Izzuddin M Aris, Yap Seng Chong, Seang Mei Saw, Peter Gluckman, Jie Jin Wang, Tien Yin Wong
AIMS/HYPOTHESIS: Changes in retinal microvasculature may reflect insulin resistance. We examined the association of changes in retinal microvasculature during pregnancy and risk of subsequent abnormal glucose metabolism in a cohort of mothers at baseline and 5 years postpartum. METHODS: Of the participants from the Singapore birth cohort (Growing Up in Singapore Towards Healthy Outcomes [GUSTO]), 276 mothers attended both baseline (at 26-28 weeks of gestation) and follow-up (5 year postpartum) visits...
December 2017: Diabetologia
https://www.readbyqxmd.com/read/28938562/the-effect-of-pre-pregnancy-body-mass-index-and-excessive-gestational-weight-gain-on-the-risk-of-gestational-diabetes-in-advanced-maternal-age
#12
Beibei Dong, Hong Yu, Qiong Wei, Mengmeng Zhi, Chunhua Wu, Xiangyun Zhu, Ling Li
BACKGROUND AND PURPOSE: With the popularization of a two-child policy in China, the number of pregnant women of advanced maternal age will increase steadily. We aimed to assess the association between pre-pregnancy body mass index (BMI) and weight gain in the first and second trimester and the risk of gestational diabetes (GDM) in the advanced maternal age group and control group defined as maternal age of 20-35 years. RESULTS: The risk of GDM for obesity before pregnancy was 2...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938429/effect-of-preconception-impaired-glucose-tolerance-on-pregnancy-outcomes-in-women-with-polycystic-ovary-syndrome
#13
MULTICENTER STUDY
Daimin Wei, Bo Zhang, Yuhua Shi, Lin Zhang, Shigang Zhao, Yanzhi Du, Lizhen Xu, Richard S Legro, Heping Zhang, Zi-Jiang Chen
Context: Women with polycystic ovary syndrome (PCOS) commonly have intrinsic insulin resistance and are recommended to undergo an oral glucose tolerance test (OGTT) for diabetes screening. However, the effect of preconception impaired glucose tolerance (IGT) on pregnancy is still unclear. Objective: To prospectively assess the effect of preconception IGT on pregnancy outcomes. Design, Setting, Patients, Interventions, and Main Outcome Measures: This was a secondary analysis of a multicenter randomized trial in 1508 women with PCOS comparing live birth and obstetric complications between fresh and frozen embryo transfer...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28918470/assessment-of-glucose-regulation-in-pregnancy-after-gastric-bypass-surgery
#14
Christian S Göbl, Latife Bozkurt, Andrea Tura, Michael Leutner, Laura Andrei, Lukas Fahr, Peter Husslein, Wolfgang Eppel, Alexandra Kautzky-Willer
AIMS/HYPOTHESIS: Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS: Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control women and 19 normal weight control women) were included. Frequently sampled 3 h OGTTs and 1 h IVGTTs were performed between 24 and 28 weeks of gestation and, in a subgroup, were repeated at 3-6 months after delivery...
December 2017: Diabetologia
https://www.readbyqxmd.com/read/28863332/screening-for-gestational-diabetes-in-tuscany-italy-a-population-study
#15
Graziano Di Cianni, Elisa Gualdani, Cecilia Berni, Alessandra Meucci, Lorenzo Roti, Cristina Lencioni, Emilia Lacaria, Giuseppe Seghieri, Paolo Francesconi
AIMS: According to current Italian guidelines, only women at higher risk of gestational diabetes (GDM) are eligible for receiving a glucose tolerance test (OGTT) during pregnancy. This study evaluates the compliance to national guidelines, additionally proposing an algorithm able to identify women with GDM. METHODS: The study included 23,270 pregnant women aged >15yr, resident in Tuscany, a region in central Italy, delivering in year 2015, identified by certificates of care at delivery...
August 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28854717/maternal-hyperglycemia-in-singleton-pregnancies-conceived-by-ivf-may-be-modified-by-first-trimester-bmi
#16
S Cai, P Natarajan, J K Y Chan, P C Wong, K H Tan, K M Godfrey, P D Gluckman, L P C Shek, F Yap, M S Kramer, S Y Chan, Y S Chong
STUDY QUESTION: Does IVF independently increase the risk of gestational diabetes mellitus (GDM) and is this increase in risk modified by maternal body mass index? SUMMARY ANSWER: IVF appears to be an independent risk factor for GDM and elevated blood glucose levels in overweight women (BMI > 25 kg/m2). WHAT IS KNOWN ALREADY: IVF has been associated with increased risk of GDM, but most previous studies did not adequately assess confounding or effect modification by other risk factors...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28852042/the-mc4r-genotype-is-associated-with-postpartum-weight-reduction-and-glycemic-changes-among-women-with-prior-gestational-diabetes-longitudinal-analysis
#17
Aline Martins de Carvalho, Ping Shao, Huikun Liu, Han-Ling Cheng, Yan Zheng, Junhong Leng, Weiqin Li, Tao Huang, Tiange Wang, Leishen Wang, Shuang Zhang, Gang Hu, Lu Qi
The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846055/homeostatic-model-assessment-of-beta-cell-function-predicting-abnormal-oral-glucose-tolerance-testing-in-pregnancy-a-systematic-review-and-meta-analysis
#18
Jonas Ellerbrock, Jolijn M H A Bohnen, Veronica A Lopes van Balen, Eva G Mulder, Robert Aardenburg, Marc E A Spaanderman
BACKGROUND: Gestational diabetes mellitus (GDM) complicates 1-14% of pregnancies and relates to increased risk of adverse obstetric outcomes. Currently GDM is diagnosed using an oral glucose tolerance test (OGTT), which is burdensome and time intensive. OBJECTIVE: To compare current literature on whether the homeostatic model assessment beta cell function (HOMA-β) is an accurate predictor of an abnormal OGTT in pregnant women. METHODS: Pubmed, Cochrane and Embase were searched...
August 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28834773/genome-wide-dna-methylation-variation-in-maternal-and-cord-blood-of-gestational-diabetes-population
#19
Jessica Kang, Chien-Nan Lee, Hung-Yuan Li, Kai-Han Hsu, Shin-Yu Lin
AIMS: Gestational diabetes mellitus (GDM) has always been a concerning issue for pregnant women. In recent studies, GDM was found to be related to epigenetic modifications, which would alter gene expressions, thus affecting the patients' and their offspring's health, leading to a higher probability of developing metabolic syndromes and diabetes later in life. METHODS: In this study, we collected both maternal and cord blood samples from 16 pregnant women and their newborns, including eight exposed to GDM...
August 9, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28833075/accuracy-of-50-g-glucose-challenge-test-to-detect-international-association-of-diabetes-and-pregnancy-study-groups-criteria-defined-hyperglycemia
#20
Biodun N Olagbuji, Adeniyi K Aderoba, Oluwatosin O Kayode, Christianah O Awe, Adesina L Akintan, Yetunde W Olagbuji
OBJECTIVES: To determine the accuracy of the 50-g glucose challenge test (GCT) in detecting hyperglycemia in pregnancy (HIP) across a range of glucose thresholds relative to the International Association of Diabetes and Pregnancy Study Groups diagnostic criteria, and to determine the accuracy of the 50-g GCT among patients with different risk status. METHODS: The present prospective cohort study included women aged 18-45 years at 24-31(+6)  weeks of pregnancy who presented at the Mother and Child Hospital, Akure, Nigeria, between September 1, 2015, and February 29, 2016...
August 21, 2017: International Journal of Gynaecology and Obstetrics
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