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https://www.readbyqxmd.com/read/28193233/tacrolimus-in-the-prevention-of-adverse-pregnancy-outcomes-and-diabetes-associated-embryopathies-in-obese-and-diabetic-mice
#1
Ahmad J H Albaghdadi, Melanie A Hewitt, Samantha M Putos, Michael Wells, Terence R S Ozolinš, Frederick W K Kan
BACKGROUND: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscarriages and fetal malformations. Despite the established association between placental insufficiency and poor maternal Th1-adaptability to the development of pregnancy complications in T2DM, there have been no established data to assess benefits of pre-pregnancy immunosuppression relative to gestational outcomes in T2DM. We hypothesized that pre-pregnancy macrolide immune suppression can re-establish normal placental development and uterine vascular adaptation in a mouse model of obesity-associated T2DM...
February 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28161191/laboratory-diagnosis-of-gestational-diabetes-an-in-silico-investigation-into-the-effects-of-pre-analytical-processing-on-the-diagnostic-sensitivity-and-specificity-of-the-oral-glucose-tolerance-test
#2
Erin Mansell, Helen Lunt, Paul Docherty
INTRODUCTION: Delayed separation of red cells from plasma causes pre analytical glucose loss, which in turn results in an under-diagnosis of GDM (gestational diabetes) based on the OGTT (oral glucose tolerance test). In silico investigations may help laboratory decision making, when exploring pragmatic improvements to sample processing. METHODS: Late pregnancy 0, 1 and 2h 75g OGTT values were obtained from two distinct populations of pregnant women: 1. Values derived from the HAPO (Hyperglycemia and Adverse Pregnancy Outcome) Study and 2...
February 2, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28129477/higher-maternal-serum-prolactin-levels-are-associated-with-reduced-glucose-tolerance-during-pregnancy
#3
Elif I Ekinci, Niloufar Torkamani, Sabashini K Ramchand, Leonid Churilov, Ken A Sikaris, Zhong X Lu, Christine A Houlihan
It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy. 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-hour glucose levels. Multivariable regression analysis demonstrated an independent and significant relationship between third trimester prolactin and 2-hour glucose levels post OGTT...
January 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28105546/gestational-diabetes-mellitus-gdm-relationship-between-higher-cutoff-values-for-100%C3%A2-g-oral-glucose-tolerance-test-ogtt-and-insulin-requirement-during-pregnancy
#4
Jessica Ares, Alicia Martín-Nieto, Lucía Díaz-Naya, Teresa Tartón, Teresa Menéndez-Prada, Cecilia S Ragnarsson, Elías Delgado-Álvarez, Edelmiro Menéndez-Torre
Objectives To study if there is any relationship about higher cutoff values for 100 g oral glucose tolerance test and the need for insulin in women diagnosed with gestational diabetes. Materials and Methods This is a retrospective population-based study of 201 women diagnosed with Gestational Diabetes Mellitus (GDM) between January 2012 and June 2014 in the area of Oviedo, Asturias, Spain. According to diagnostic criteria recommended by GEDE, NDDG, gestational diabetes is diagnosed if two or more plasma glucose levels meet or exceed the following threshold: fasting glucose of 105 mg/dl, 1-h 190 mg/dl, 2-h 165 mg/dl, or 3-h 145 mg/dl...
January 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28095377/associations-of-maternal-leptin-with-neonatal-adiposity-differ-according-to-pregravid-weight
#5
Julie Patenaude, Guillaume Lacerte, Marilyn Lacroix, Laetitia Guillemette, Catherine Allard, Myriam Doyon, Marie-Claude Battista, Julie Moreau, Julie Ménard, Jean-Luc Ardilouze, Patrice Perron, Marie-France Hivert
BACKGROUND: During pregnancy, maternal circulating leptin is released by maternal adipose tissue and the placenta, and may have a role in fetal development. OBJECTIVES: We investigated maternal leptinemia and glycemia associations with neonatal adiposity, taking into account pregravid weight status. METHODS: We included 235 pregnant women from the Genetics of Glucose Regulation in Gestation and Growth prospective cohort with data: blood samples collected during the 2nd trimester, an oral glucose tolerance test (OGTT), and the measured leptin and glucose levels...
January 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28090333/urinary-c-peptide-creatinine-ratio-in-pregnant-women-with-normal-glucose-tolerance-and-type-1-diabetes-evidence-for-insulin-secretion
#6
Ankica Markoska, Rajalakshmi Valaiyapathi, Chloe Thorn, Anne Dornhorst
HYPOTHESIS: In pregnancy, urinary C peptide creatinine ratio (UCPCR) reflects endogenous insulin secretion in women with normal glucose tolerance and type 1 diabetes. RESEARCH DESIGN AND METHODS: UCPCR and serum C peptide were measured in 90 glucose-tolerant women at 0 and 120 min during a 75 g oral glucose tolerance test (OGTT) at 28 weeks of gestation. UCPCR was measured in 2 samples obtained over 10 weeks apart in 7 pregnant women with longstanding type 1 diabetes...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28076942/prevalence-of-gestational-diabetes-mellitus-in-a-suburban-district-in-sri-lanka-a-population-based-study
#7
B H Sudasinghe, P S Ginige, C N Wijeyaratne
Introduction: GDM is a leading metabolic cause of morbidity to mother and offspring. Determining its prevalence is important for health planning and implementation. Objective: Assess prevalence of GDM in the District of Gampaha. Method: Community based cross-sectional study was conducted in women attending field-based ante-natal clinics in two Medical Officer of Health (MOH) areas between January 2014 to March 2015. Consecutive women were recruited by cluster sampling with probability proportionate to size using strict exclusion criteria...
30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28072873/association-study-with-77-snps-confirms-the-robust-role-for-the-rs10830963-g-of-mtnr1b-variant-and-identifies-two-novel-associations-in-gestational-diabetes-mellitus-development
#8
Klara Rosta, Zahra Al-Aissa, Orsolya Hadarits, Jürgen Harreiter, Ákos Nádasdi, Fanni Kelemen, Dagmar Bancher-Todesca, Zsolt Komlósi, László Németh, János Rigó, István Sziller, Anikó Somogyi, Alexandra Kautzky-Willer, Gábor Firneisz
CONTEXT: Genetic variation in human maternal DNA contributes to the susceptibility for development of gestational diabetes mellitus (GDM). OBJECTIVE: We assessed 77 maternal single nucleotide gene polymorphisms (SNPs) for associations with GDM or plasma glucose levels at OGTT in pregnancy. METHODS: 960 pregnant women (after dropouts 820: case/control: m99'WHO: 303/517, IADPSG: 287/533) were enrolled in two countries into this case-control study...
2017: PloS One
https://www.readbyqxmd.com/read/28068986/leptin-and-adiponectin-as-predictors-of-cardiovascular-risk-after-gestational-diabetes-mellitus
#9
Tove Lekva, Annika Elisabet Michelsen, Pål Aukrust, Tore Henriksen, Jens Bollerslev, Thor Ueland
BACKGROUND: Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy. METHODS: This population-based prospective cohort included 300 women who had an oral glucose tolerance test (OGTT) during pregnancy...
January 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28053673/diagnostic-protocol-for-gestational-diabetes-mellitus-gdm-iadpsg-ada-2011-influence-on-the-occurrence-of-gdm-and-mild-gestational-hyperglycemia-mgh-and-on-the-perinatal-outcomes
#10
Mariana Pinto Sirimarco, Helena Maciel Guerra, Eduardo Guimarães Lisboa, Joice Monalisa Vernini, Bianca Nicolosi Cassetari, Roberto Antonio de Araujo Costa, Marilza Vieira Cunha Rudge, Iracema de Mattos Paranhos Calderon
BACKGROUND: In August 2011, the Specialized Center for Diabetes and Pregnancy of the Botucatu Medical School/Unesp adopted a new diagnostic protocol for gestational diabetes mellitus, recommended by the American Diabetes Association and the International Association of the Diabetes and Pregnancy Study Group. The glycemic profile was evaluated using the 75-g oral glucose tolerance test (OGTT) used to diagnose mild gestational hyperglycemia, recognized and treated in our department as gestational diabetes mellitus...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28050671/adiponectin-and-leptin-gene-polymorphisms-in-women-with-gestational-diabetes-mellitus
#11
Andrzej Pawlik, Joanna Teler, Agnieszka Maciejewska, Marek Sawczuk, Krzysztof Safranow, Violetta Dziedziejko
PURPOSE: Gestational diabetes mellitus (GDM) is the glucose intolerance occurring during pregnancy. The prevalence of GDM is increased in obese women. Leptin and adiponectin are adipokines that play an important role in the regulation of insulin secretion and glucose and lipid metabolism. The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and the development of GDM. METHODS: This case-control study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT)...
January 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28029217/gestational-diabetes-alters-the-fetal-heart-rate-variability-during-an-oral-glucose-tolerance-test-a-fetal-magnetocardiography-study
#12
E Fehlert, K Willmann, L Fritsche, K Linder, H Mat-Husin, F Schleger, M Weiss, I Kiefer-Schmidt, S Brucker, H-U Häring, H Preissl, A Fritsche
OBJECTIVE: Gestational diabetes mellitus (GDM) potentially harms the child before birth. We previously found GDM to be associated with developmental changes in the central nervous system. We now hypothesise that GDM may also impact on the fetal autonomic nervous system under metabolic stress like an oral glucose tolerance test (OGTT). DESIGN: We measured heart rate variability (HRV) of mothers and fetuses during a three-point OGTT using fetal magnetocardiography (fMCG)...
December 28, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27999478/prevalence-of-gestational-diabetes-in-the-southern-part-of-bosnia-and-herzegovina
#13
Vajdana Tomic, Marinko Misic, Ana Dugandzic Simic, Ana Boskovic, Tanja Kresic, Olivera Peric, Martina Orlovic, Ivana Culjak Blagojevic
BACKGROUND: The prevalence of gestational diabetes mellitus (GDM), as a complex problem in pregnancy, is increasing all over the world, but most noticeable in developing countries. AIMS: To estimate GDM prevalence and associated pregnancy features in the southern part of Bosnia and Herzegovina. METHODS: A cross-sectional observational study was conducted from October 2010 through March 2011. A total of 285 pregnant women with singleton pregnancies participated and were asigned to the study in the order they came for their usual ante-natal clinic examination...
October 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27982199/elevated-igf-1-with-gh-suppression-after-an-oral-glucose-overload-incipient-acromegaly-or-false-positive-igf-1
#14
Pedro W Rosario, Maria R Calsolari
Objective: To report the evolution of patients with a suggestive clinical scenario and elevated serum insulin-like growth factor-1 (IGF-1), but growth hormone (GH) suppression in the oral glucose tolerance test (OGTT), in whom acromegaly was not initially excluded. Subjects and methods: Forty six patients with a suggestive clinical scenario, who had elevated IGF-1 (outside puberty and pregnancy) in two measurements, but GH < 0.4 µg/L in the OGTT, were selected...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27981358/associations-of-maternal-bmi-and-insulin-resistance-with-the-maternal-metabolome-and-newborn-outcomes
#15
Victoria Sandler, Anna C Reisetter, James R Bain, Michael J Muehlbauer, Michael Nodzenski, Robert D Stevens, Olga Ilkayeva, Lynn P Lowe, Boyd E Metzger, Christopher B Newgard, Denise M Scholtens, William L Lowe
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediated through the intrauterine environment. We aimed to characterise the maternal metabolic milieu associated with maternal BMI and its relationship to newborn birthweight and adiposity. METHODS: Fasting and 1 h serum samples were collected from 400 European-ancestry mothers in the Hyperglycaemia and Adverse Pregnancy Outcome Study who underwent an OGTT at ∼28 weeks gestation and whose offspring had anthropometric measurements at birth...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27936083/effectiveness-and-cost-effectiveness-of-a-cluster-randomized-prenatal-lifestyle-counseling-trial-a-seven-year-follow-up
#16
Päivi Kolu, Jani Raitanen, Jatta Puhkala, Pipsa Tuominen, Pauliina Husu, Riitta Luoto
There is a link between the pregnancy and its long-term influence on health and susceptibility to future chronic disease both in mother and offspring. The objective was to determine whether individual counseling on physical activity and diet and weight gain at five antenatal visits can prevent type 2 diabetes mellitus (T2DM) and overweight or improve glycemic parameters, among all at-risk-mothers and their children. Another objective was to evaluate whether gestational lifestyle intervention was cost-effective as measured with mother's sickness absence and quality-adjusted life years (QALY)...
2016: PloS One
https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#17
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27916501/association-between-iron-level-glucose-impairment-and-increased-dna-damage-during-pregnancy
#18
Salam Zein, Samar Rachidi, Nadine Shami, Iman Sharara, Khawla Cheikh-Ali, Anne-Sophie Gauchez, Jean-Marc Moulis, Jean-Marc Ayoubi, Pascale Salameh, Isabelle Hininger-Favier
: Elevated circulating ferritin has been reported to increase the risk of gestational diabetes mellitus (GDM). When high ferritin translates into high iron stores, iron excess is also a condition leading to free radical damage. We aimed to evaluate the relationship between oxidative stress (OS) induced by iron status and GDM risk in non iron-supplemented pregnant women. METHODS: This was a pilot observational study conducted on 93 non-anemic pregnant women. Iron status was assessed at the first trimester of gestation...
November 18, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27911105/associations-between-maternal-bmi-as-well-as-glucose-tolerance-and-adverse-pregnancy-outcomes-in-women-with-polycystic-ovary-syndrome
#19
Ying-Ying Li, Su-Qi Ye, Zhuo-Hui Zhong, Qiong Xu, Wei-Bi Mai, Cai-Xin Yin, Zhi-Qin Zhu, Xiao-Qian He, Qing Xiao
This retrospective, cohort study examined the association between maternal pre-pregnancy body mass index (BMI), independent of glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), for which there are few previous studies. Medical records from 2012 to 2015 at Guangzhou Women and Children's Medical Center, China were reviewed for women previously diagnosed with PCOS with normal 2-h 75-g oral glucose tolerance test (OGTT) results (n = 1249). The separate and joint effects of maternal BMI and glucose levels on pregnancy outcomes were assessed...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27863107/heterogeneity-of-glycometabolism-in-patients-with-gestational-diabetes-mellitus-retrospective-study-of-1-683-pregnant-women
#20
Yan Yan, Zhou Liu, Daqing Liu
AIMS/INTRODUCTION: To evaluate the glycometabolism and outcomes of gestational diabetes mellitus (GDM) patients according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria in China. MATERIALS AND METHODS: According to the results of a 75-g oral glucose tolerance test, 1,683 pregnant women were divided into three groups: (i) an increment GDM group (patients meet the IADPSG criteria, but not the previous Chinese criteria); (ii) a stock GDM group (patients meet both criteria); and (iii) a normal glucose tolerance group...
November 10, 2016: Journal of Diabetes Investigation
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