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https://www.readbyqxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#1
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29747594/the-treatment-of-booking-gestational-diabetes-mellitus-tobogm-pilot-randomised-controlled-trial
#2
David Simmons, Jodie Nema, Chloe Parton, Lisa Vizza, Annette Robertson, Rohit Rajagopal, Jane Ussher, Janette Perz
BACKGROUND: We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment. METHODS: Consecutive, consenting women < 20 weeks gestation, with GDM risk factors attending the hospital book-in clinic, completed an oral glucose tolerance test (OGTT). Clinicians were blinded to OGTT results. Women fulfilling World Health Organisation GDM criteria were randomised to either clinic referral /ongoing treatment (Treated Group n = 11), or no treatment (No Treatment Group n = 10)...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29739812/risk-factors-for-hyperglycemia-in-pregnancy-in-the-dali-study-differ-by-period-of-pregnancy-and-ogtt-time-point
#3
Lilian C Mendoza, Jürgen Harreiter, David Simmons, Gernot Desoye, Juan María Adelantado, Fabiola Juarez, Ana Chico, Roland Devlieger, Andre Van Assche, Sander Galjaard, Peter Damm, Elisabeth Mathiesen, Dorte M Jensen, Lise Lotte Andersen, Mette Tanvig, Annunziata Lapolla, Maria G Dalfra, Alessandra Bertolotto, Urszula Mantaj, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Judith Jelsma, Fj Snoek, Mireille Van Poppel, Christof Worda, Dagmar Bancher-Todesca, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy
OBJECTIVE Risk factors are widely used to identify women at risk for gestational diabetes mellitus (GDM) without clear distinction by pregnancy period or oral glucose tolerance test (OGTT) time points. We aimed to assess clinical risk factors for HiP differentiating by these two aspects. DESIGN AND METHODS 971 overweight/obese pregnant women, enrolled in the DALI study for preventing GDM. OGTTs were performed at ≤19+6, 24-28 and 35-37 weeks (IADPSG/WHO2013 criteria). Women with GDM or overt diabetes at one time point did not proceed to further OGTTs...
May 8, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29728773/the-post-hapo-situation-with-gestational-diabetes-the-bright-and-dark-sides
#4
Annunziata Lapolla, Boyd E Metzger
AIM: In 2010, in light of the data coming from the HAPO study, the International Association of Diabetes and Pregnancy Study Groups (IADPSG) proposed a new detection strategy and diagnostic criteria for gestational diabetes based on a one-step approach with a 75 g OGTT. This review analyzes and discusses the bright and dark sides of their application. METHODS: The assessment of these recommendations by the international organizations involved in the care of gestational diabetes and a series of observational, retrospective and prospective studies that have been published since 2010 regarding the use of the IADPSG recommendations have been evaluated...
May 4, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29724737/insulin-sensitivity-assessed-using-urine-c-peptide-creatinine-ratio-ucpcr-in-pregnancy-cross-sectional-analysis-of-an-english-multiethnic-cohort
#5
Ankica Markoska, Lilian C Mendoza, Rajalakshmi Valaiyapathi, Chloe Thorn, Anne Dornhorst
AIMS: To assess urinary C peptide creatinine ratio (UCPCR) used in a modified Matsuda equation to measure insulin sensitivity (IS) in pregnancy. RESEARCH AND DESIGN METHODS: In this cross-sectional study, two IS measurements were calculated in 73 pregnant women at ~28 weeks of gestation by two separate methods using modified Matsuda equations. The first using the 0 and 120 min serum C peptide concentration during a 75 g oral glucose tolerance test (OGTT) and the second using the 0 and 120 min UCPCR values...
May 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29712482/does-pregnancy-interval-after-laparoscopic-sleeve-gastrectomy-affect-maternal-and-perinatal-outcomes
#6
Alper Basbug, Aşkı Ellibeş Kaya, Sami Dogan, Mevlut Pehlivan, Gokhan Goynumer
BACKGROUND: Obesity is a global health epidemic and is associated with many maternal and neonatal complications. Laparoscopic sleeve gastrectomy (LSG) is among the surgical treatments for obesity. The appropriate timing of pregnancy following LSG remains controversial and few studies have evaluated this public health issue. OBJECTIVE: To evaluate the effect of pregnancy timing after LSG on maternal and perinatal outcomes. STUDY DESIGN: We performed a retrospective observational study of 23 pregnant women who underwent LSG at a tertiary hospital in Turkey...
April 30, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29666171/comparisons-of-the-oxidative-stress-biomarkers-level-in-gdm-and-non-gdm-among-thai-population-cohort-study
#7
Hathairat Rueangdetnarong, Rattanaporn Sekararithi, Thidarat Jaiwongkam, Sirinart Kumfu, Nipon Chattipakorn, Theera Tongsong, Phudit Jatavan
OBJECTIVE: The primary objective of this study was to compare the levels of oxidative stress biomarkers between pregnancies with GDM and normoglycemic pregnancies. METHODS: A prospective study was conducted on pregnant women at average risk for GDM. The participants were confirmed by 100 g, 3-hour OGTT and categorized into the Control (non-GDM) and GDM groups. All participants were collected for maternal blood at GA 24-28 weeks and early labor and fetal cord blood for measurements of 8-Isoprostane (oxidative stress maker), TNF-α (inflammatory marker) and IL-10 (anti-inflammatory marker) and were followed-up for maternal and neonatal outcomes...
April 17, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29660612/perfluoroalkyl-substances-and-glycemic-status-in-pregnant-danish-women-the-odense-child-cohort
#8
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Helle Raun Andersen, Philippe Grandjean, Tina Kold Jensen, Marianne Andersen
BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent chemicals with suspected endocrine disrupting abilities applied in consumer products. PFASs have potentially modulating effects on glucose homeostasis. Insulin resistance prevails during third trimester of pregnancy, and this challenge of glucose homeostasis may reveal putative effects of PFAS concentrations on glycemic status. OBJECTIVE: To investigate associations between five serum PFASs and glucose-related outcomes in pregnant Danish women based on their risk of gestational diabetes mellitus (GDM)...
April 13, 2018: Environment International
https://www.readbyqxmd.com/read/29649540/incidence-risk-factors-and-pregnancy-outcomes-of-gestational-diabetes-mellitus-using-one-step-versus-two-step-diagnostic-approaches-a-population-based-cohort-study-in-isfahan-iran
#9
Elham Hosseini, Mohsen Janghorbani, Ashraf Aminorroaya
AIMS: To study the incidence, risk factors, and pregnancy outcomes associated with gestational diabetes mellitus (GDM) diagnosed with one-step and two-step screening approaches. METHODS: 1000 pregnant women who were eligible and consented to participate underwent fasting plasma glucose testing at the first prenatal visit (6-14 weeks). The women free from GDM or overt diabetes were screened at 24-28 weeks using the 50-g glucose challenge test (GCT) followed by 100-g, 3-h oral glucose tolerance test (OGTT) (two-step method)...
April 10, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29624902/one-hour-ogtt-plasma-glucose-at-gdm-diagnosis-is-a-common-predictor-of-the-need-for-insulin-therapy-in-pregnancy-and-postpartum-impaired-glucose-tolerance
#10
Takeshi Nishikawa, Keiko Ono, Shoko Hashimoto, Hiroyuki Kinoshita, Takuro Watanabe, Hirotaka Araki, Kae Otsu, Wakana Sakamoto, Masahiro Harada, Tetsushi Toyonaga, Shoichi Kawakami, Jyunichiro Fukuda, Yoshio Haga, Daisuke Kukidome, Takeshi Takahashi, Eiich Araki
AIMS/INTRODUCTION: Because gestational diabetes mellitus (GDM) is a risk for adverse perinatal outcomes, and patients with a history of GDM have an increased risk of impaired glucose tolerance (IGT). Here, we conducted two non-interventional and retrospective studies of GDM patients in Japan. MATERIALS AND METHODS: In the first study, we enrolled 529 GDM patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum IGT...
April 6, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29608977/ethnic-differences-in-antepartum-glucose-values-that-predict-postpartum-dysglycemia-and-neonatal-macrosomia
#11
Olubukola Ajala, Constance Chik
BACKGROUND AND OBJECTIVE: Gestational diabetes (GDM) occurs more often in women from certain ethnic groups and is also associated with fetal macrosomia. In this study, we investigated the ability of a gestational diabetes screening test (GDS), the 2hour 75gram-Oral Glucose Tolerance Test (OGTT), and glycated hemoglobin (HbA1c) in predicting postpartum dysglycemia and fetal macrosomia in women of Caucasian, Filipino, Chinese and South-Asian descent. METHODS: 848 women diagnosed with carbohydrate intolerance in pregnancy who completed a 2hour 75g- OGTT within 6 months postpartum, were included in the study...
March 30, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29596944/postpartum-risk-of-diabetes-and-predictive-factors-for-glucose-intolerance-in-east-asian-women-with-gestational-diabetes
#12
Hiromi Inoue, Ko Ishikawa, Kenji Takeda, Akina Kobayashi, Kenichi Kurita, Jin Kumagai, HidetakaYokoh, Koutaro Yokote
AIMS: Women with a history of gestational diabetes mellitus (GDM) are likely to develop postpartum diabetes mellitus (DM). We examined women in the early stages of pregnancy who were at high risk of postpartum DM progression to establish a follow-up method for early detection. METHODS: We performed the oral glucose tolerance test (OGTT) and identified predictive factors for postpartum impaired glucose tolerance (IGT) or DM in 77 women after GDM, for 2 years after delivery, retrospectively...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29590381/the-circadian-rhythm-related-mtnr1b-genotype-gestational-weight-gain-and-postpartum-glycemic-changes
#13
Hoirun Nisa, Kevin H T Qi, Junhong Leng, Tao Zhou, Huikun Liu, Weiqin Li, Leishen Wang, Nan Li, Gang Hu, Lu Qi
Context: Disturbed circadian rhythms and sleep quality during pregnancy have been related to gestational weight gain and gestational diabetes mellitus (GDM), which affect postpartum glucose metabolism and future risk of type 2 diabetes. Objective: We assessed whether the circadian rhythm-related melatonin receptor 1B (MTNR1B) genotype was associated with 1-5 years of postpartum glycemic changes among women with a history of GDM; and whether gestational weight gain modified such associations...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29587878/is-afamin-a-novel-biomarker-for-gestational-diabetes-mellitus-a-pilot-study
#14
Angela Köninger, Annette Mathan, Pawel Mach, Mirjam Frank, Boerge Schmidt, Ekkehard Schleussner, Rainer Kimmig, Alexandra Gellhaus, Hans Dieplinger
BACKGROUND: In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E-binding protein in human plasma.. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome. During uncomplicated pregnancy its serum concentrations increase linearly. The aim of this study was to investigate the suitability of afamin as early marker for predicting GDM...
March 27, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29576523/predictors-of-metformin-failure-in-gestational-diabetes-mellitus-gdm
#15
May Oo Khin, Simon Gates, Ponnusamy Saravanan
INTRODUCTION AND OBJECTIVE: The role of metformin in gestational diabetes mellitus (GDM) is also increasing. However, almost half of metformin-treated women required additional insulin. Therefore, identifying the characteristics of these women may help define optimal therapeutic strategy. METHODS: This is a retrospective cohort study done in a District General Hospital, UK. GDM was diagnosed by 75 g OGTT test between 24 and 28 weeks of gestation with fasting levels of ≥6...
May 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29561188/short-term-sitagliptin-metformin-therapy-is-more-effective-than-metformin-or-placebo-in-prior-gestational-diabetic-women-with-impaired-glucose-regulation
#16
Karen E Elkind-Hirsch, Martha S Paterson, Donna Shaler, Hanh C Gutowski
OBJECTIVE: Our pilot study examined the effectiveness of sitagliptin-metformin (SITA-MET), metformin (MET), and placebo (P) therapy on fasting and post-glucose challenge glucose levels in postpartum women with prior gestational diabetes mellitus (GDM) and impaired glucose regulation. METHODS: Prediabetic women (N = 36, age 18 to 42 years) with recent GDM were randomized to P (one pill twice a day), MET (1,000 mg twice a day), or SITA-MET (50 mg SITA, 1,000 mg MET twice a day) for 16 weeks in a single-blind fashion...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29558635/non-dioxin-like-polychlorinated-biphenyls-in-early-pregnancy-and-risk-of-gestational-diabetes-mellitus
#17
Lei Zhang, Xin Liu, Guimin Meng, Min Chi, Jingguang Li, Shuaixing Yin, Yunfeng Zhao, Yongning Wu
Several studies support a plausible association of human exposure to polychlorinated biphenyls (PCBs) with type 2 diabetes mellitus. However, little is known about the potential link between circulating PCBs levels in early pregnancy and development of gestational diabetes mellitus (GDM). Here, we conducted a prospective study with a nested case-control design to determine the association of PCB exposure in early pregnancy with GDM risk. Concentrations of selected so-called 'indicator PCBs' were determined in sera of women in the first trimester of pregnancy via gas chromatography - high resolution mass spectrometry...
June 2018: Environment International
https://www.readbyqxmd.com/read/29550360/development-of-a-risk-engine-relating-maternal-glycemia-and-body-mass-index-to-pregnancy-outcomes
#18
REVIEW
H David McIntyre, Kristen S Gibbons, Julia Lowe, Jeremy J N Oats
AIMS: To develop a risk "engine" or calculator, integrating the risks of hyperglycemia, maternal BMI and other basic demographic data commonly available at the time of the pregnancy oral glucose tolerance test (OGTT), to predict an individual's absolute risk of specific adverse pregnancy outcomes. METHODS: Data from the Brisbane HAPO cohort was analysed using logistic regression to determine the relationship between four clinical outcomes (primary CS, birth injury, large-for-gestational age, excess neonatal adiposity) with different combinations of OGTT results and maternal demographics (age, height, BMI, parity)...
May 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29545111/gestational-diabetes-mellitus-using-the-fasting-plasma-glucose-level-to-simplify-the-international-association-of-diabetes-and-pregnancy-study-groups-diagnostic-algorithm-in-an-adult-south-asian-population
#19
Mukesh M Agarwal, John Punnose, Komal Sukhija, Asha Sharma, Naimaa K Choudhary
OBJECTIVES: To evaluate the value of the fasting plasma glucose (FPG) level for simplifying the International Association of Diabetes and Pregnancy Study Groups (IADPSG) diagnostic algorithm of gestational diabetes mellitus (GDM) in a South Asian population. METHODS: In 6,520 pregnant women undergoing universal screening with the 75 g oral glucose tolerance test (OGTT), the area under receiver operating characteristic curve was used to determine the overall FPG performance to detect GDM (IADPSG criteria)...
December 15, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29528396/increased-expression-of-microrna-15a-and-microrna-15b-in-skeletal-muscle-from-adult-offspring-of-women-with-diabetes-in-pregnancy
#20
Azadeh Houshmand-Oeregaard, Maren Schrölkamp, Louise Kelstrup, Ninna S Hansen, Line Hjort, Anne Cathrine B Thuesen, Christa Broholm, Elisabeth R Mathiesen, Tine D Clausen, Allan Vaag, Peter Damm
Offspring of women with diabetes in pregnancy exhibit skeletal muscle insulin resistance and are at increased risk of developing type 2 diabetes, potentially mediated by epigenetic mechanisms or changes in the expression of small non-coding microRNAs. Members of the miR-15 family can alter the expression or function of important proteins in the insulin signalling pathway, affecting insulin sensitivity and secretion. We hypothesized that exposure to maternal diabetes may cause altered expression of these microRNAs in offspring skeletal muscle, representing a potential underlying mechanism by which exposure to maternal diabetes leads to increased risk of cardiometabolic disease in offspring...
May 15, 2018: Human Molecular Genetics
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