keyword
https://read.qxmd.com/read/38533283/insulin-sensitivity-islet-cell-function-and-incretin-axis-in-pregnant-women-with-and-without-gestational-diabetes-mellitus
#1
JOURNAL ARTICLE
Niya Narayanan, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Haritha Sagili, Bobby Zachariah, Dukhabandhu Naik, Ayan Roy, Chandhana Merugu
INTRODUCTION: The aim of this study was to compare insulin sensitivity, islet cell function, and incretin axes in pregnant subjects with GDM and normal healthy controls. METHODS: Pregnant women at 24 to 28 weeks of gestation were subjected to a 75 g oral glucose tolerance test (OGTT). Samples for glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were collected at 0, 30, 60, and 120 min during the OGTT...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38529396/safety-tolerability-pharmacokinetics-and-pharmacokinetic-pharmacodynamic-modeling-of-cetagliptin-in-patients-with-type-2-diabetes-mellitus
#2
JOURNAL ARTICLE
Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie, Feng Shao
AIMS: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with type 2 diabetes mellitus (T2DM). A population PK/PD model was developed to quantify the PK and PD characteristics of cetagliptin in patients. MATERIALS AND METHODS: 32 Chinese adults with T2DM were enrolled in this study. The subjects were randomly assigned to receive either cetagliptin (50 mg or 100 mg), placebo, or sitagliptin (100 mg) once daily for 14 days...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38524937/risk-factors-of-late-onset-gestational-diabetes-diagnosed-during-24-28%C3%A2-weeks-of-gestation-after-normal-early-screening-a-case-control-study
#3
JOURNAL ARTICLE
Dittakarn Boriboonhirunsarn, Kwanjutha Jetsadakraisorn
OBJECTIVE: To determine the risk factors associated with late-onset GDM (diagnosed between 24 and 28 weeks of gestation) after normal early screening. METHODS: A case-control study was conducted in 600 singleton pregnant women who started antenatal care before 20 weeks with normal early GDM screening. Repeat screening was performed at 24-28 weeks. Cases were 120 women with late-onset GDM and 480 controls were those without GDM. Risk factors for late-onset GDM were evaluated and pregnancy outcomes were compared...
April 2024: Diabetology International
https://read.qxmd.com/read/38518263/greater-glycemic-control-following-low-load-high-repetition-resistance-exercise-compared-with-moderate-intensity-continuous-exercise-in-males-and-females-a-randomized-control-trial
#4
JOURNAL ARTICLE
Kayleigh M Beaudry, Julian C Surdi, Kristian Pancevski, Cory Tremblay, Michaela Devries-Aboud
Exercise has long been known for its beneficial effects on insulin sensitivity (IS) and glucose handling with both moderate-intensity continuous (MIC) exercise and resistance exercise (RE) inducing beneficial effects. In recent years, low-load high repetition (LLHR) RE has emerged as a strategy to increase muscle mass and strength to levels similar to traditional RE, however the effects of LLHR RE on glucose handling has yet to be investigated. The purpose of this trial was to compare the acute effects of LLHR RE to MIC exercise on post-exercise glycemic control and insulin sensitivity in males and females...
March 22, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38516715/abdominal-subcutaneous-fat-thickness-combined-with-a-50-g-glucose-challenge-test-at-24-28-weeks-of-pregnancy-in-predicting-gestational-diabetes-mellitus
#5
JOURNAL ARTICLE
Süleyman Cemil Oğlak, Emine Zeynep Yılmaz, Mehmet Şükrü Budak
BACKGROUND: This investigation aimed to analyse the efficacy of abdominal subcutaneous fat thickness (ASFT) value >18.1 mm combined with a 50-g glucose challenge test (GCT) between 24-28 weeks of gestation in predicting gestational diabetes mellitus (GDM) cases. METHODS: This cross-sectional study was carried out from February 2021 to December 2022. All pregnant women received a 50-g GCT at 24-28 weeks of pregnancy for the GDM screening. Pregnant women with a blood glucose value between 140-190 mg/dl experienced 100 g OGTT...
December 2024: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/38510652/evaluating-the-effectiveness-of-a-novel-somatostatin-receptor-2-antagonist-zt-01-for-hypoglycemia-prevention-in-a-rodent-model-of-type-2-diabetes
#6
JOURNAL ARTICLE
Ninoschka C D'Souza, Julian A Aiken, Emily G Hoffman, Sara C Atherley, Sabrina Champsi, Nadia Aleali, Dorsa Shakeri, Maya El-Zahed, Nicky Akbarian, Mehran Nejad-Mansouri, Parinaz Z Bavani, Richard L Liggins, Owen Chan, Michael C Riddell
Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabetes (T2D), particularly when insulin therapy is initiated, but the utility of SSTR2 antagonists in ameliorating hypoglycemia in this disease state is unknown. We examined the efficacy of a single-dose of SSTR2 antagonists in a rodent model of T2D. Methods: High-fat fed (HFF), low dose streptozotocin (STZ, 35 mg/kg)-induced T2D and HFF only, nondiabetic (controls-no STZ) rats were treated with the SSTR2 antagonists ZT-01/PRL-2903 or vehicle ( n = 9-11/group) 60 min before an insulin tolerance test (ITT; 2-12 U/kg insulin aspart) or an oral glucose tolerance test (OGTT; 2 g/kg glucose via oral gavage) on separate days...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38504539/mechanisms-of-dangua-fang-in-multi-target-and-multi-method-regulation-of-glycolipid-metabolism-based-on-phosphoproteomics
#7
JOURNAL ARTICLE
Heng Xianpei, Wang Zhita, L I Liang, Yang Liuqing, Huang Suping, Jin Lang, H E Weidong
OBJECTIVE: To explore the mechanism of Dangua Fang (, DGR) in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics. METHODS: Sprague-Dawley rats with normal glucose levels were randomly divided into three groups, including a conventional diet control group (Group A), high-fat-high-sugar diet model group (Group B), and DGR group (Group C, high-fat-high-sugar diet containing 20.5 g DGR). After 10 weeks of intervention, the fasting blood glucose (FBG), 2 h blood glucose [PBG; using the oral glucose tolerance test (OGTT)], hemoglobin A1c (HbA1c), plasma total cholesterol (TC), and triglycerides (TG) were tested, and the livers of rats were removed to calculate the liver index...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38503114/hypoglycaemia-following-the-2-hour-75g-ogtt-in-pregnancy-investigating-maternal-and-foetal-outcomes
#8
JOURNAL ARTICLE
Callum Blunt, Susan Mathew, Sai Man Mung, Roopa Krishnamurthy, Edward B Jude
AIMS: To investigate differences in maternal and foetal outcomes in pregnancy, where patients developed hypoglycaemia following the 2-hour 75g oral glucose tolerance test (OGTT). METHOD: A retrospective cohort study of 200 pregnancies attending the Antenatal Clinic at Tameside General Hospital between 2018 and 2022. Outcomes were compared between 4 groups: normal OGTT [G1; (n = 39, 20%), diagnosis of gestational diabetes mellitus (GDM) based on OGTT [G2; BG ≥ 5...
March 8, 2024: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/38501230/plasma-ceramides-and-other-sphingolipids-in-relation-to-incident-prediabetes-in-a-longitudinal-biracial-cohort
#9
JOURNAL ARTICLE
Samuel Dagogo-Jack, Peace Asuzu, Jim Wan, Richard Grambergs, Frankie Stentz, Nawajes Mandal
CONTEXT: Sphingolipids are linked to the pathogenesis of type 2 diabetes (T2D). OBJECTIVE: To test the hypothesis that plasma sphingolipid profiles predict incident prediabetes. DESIGN: A case-control study nested in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study, a 5-year follow-up study. SETTING: Academic health center. PARTICIPANTS: Normoglycemic adults enrolled in the POP-ABC study...
March 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38499685/metabolic-health-tracking-using-ultrahuman-m1-continuous-glucose-monitoring-platform-in-non-and-pre-diabetic-indians-a-multi-armed-observational-study
#10
JOURNAL ARTICLE
Monik Chaudhry, Mohit Kumar, Vatsal Singhal, Bhuvan Srinivasan
Continuous glucose monitoring (CGM) device adoption in non- and pre-diabetics for preventive healthcare has uncovered a paucity of benchmarking data on glycemic control and insulin resistance for the high-risk Indian/South Asian demographic. Furthermore, the correlational efficacy between digital applications-derived health scores and glycemic indices lacks clear supportive evidence. In this study, we acquired glycemic variability (GV) using the Ultrahuman (UH) M1 CGM, and activity metrics via the Fitbit wearable for Indians/South Asians with normal glucose control (non-diabetics) and those with pre-diabetes (N = 53 non-diabetics, 52 pre-diabetics) for 14 days...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38497098/clinical-utility-of-point-of-care-glucose-testing-in-the-assessment-of-gestational-diabetes-prospective-cohort-study
#11
JOURNAL ARTICLE
Wiaam Al-Hasani, Ruvini Ranasinghe, Helen Rogers, William Spanier, Katie Spears, Carol Gayle, Lisa Long, Georgios K Dimitriadis, Katharine F Hunt, Royce P Vincent
OBJECTIVE: To assess the clinical utility of point-of-care (POC) capillary blood glucose (CBG) testing in the assessment of gestational diabetes mellitus (GDM) during oral glucose tolerance test (OGTT). DESIGN: Prospective cohort study. SETTING: Antenatal clinics at King's College Hospital. POPULATION: Women screened for GDM between March and June 2020. METHODS: The CBG was measured using the POC StatStrip® test and the venous plasma glucose (VPG) was measured by Roche analyser (Cobas 8000 c702)...
March 18, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/38488897/does-the-combination-of-four-ogtt-values-enhance-the-prediction-of-adverse-pregnancy-outcomes-insights-from-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Liat Mor, Ella Toledano, Noa Ben-Shoshan, Eran Weiner, Yael Ganor Paz, Giulia Barda, Michal Levy
AIM: To explore the correlation between a singular value of additive OGTT scores and adverse maternal and neonatal outcomes. We postulated that a higher additive OGTT score would predict poorer maternal and neonatal outcomes. METHODS: In this retrospective cohort study, data were collected from all women with a documented complete OGTT result and subsequent diagnosis of GDM. The additive OGTT score was calculated by adding each individual hourly glucose measurement...
March 15, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38488037/reversibility-of-hyperglycemic-states-in-children-with-obesity-diagnostic-pitfalls-in-the-assessment-of-glucose-metabolism-in-children-and-adolescents-with-obesity
#13
JOURNAL ARTICLE
Anna Iwańska, Małgorzata Wójcik, Ewa Szczudlik, Anna Stępniewska, Jerzy B Starzyk
OBJECTIVE: Disorders of glucose metabolism in children with obesity are less common than in adults. There is also evidence that they may be transient. The aim of this study was to determine the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and its reversibility in pediatric patients with obesity and to define the factors determining the reversibility of prediabetes or progression to diabetes. METHODS: Retrospective analysis included 573 patients with obesity (mean BMI Z-score 4...
March 15, 2024: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/38486097/gestational-diabetes-mellitus-hypertension-and-dyslipidemia-as-the-risk-factors-of-preeclampsia
#14
JOURNAL ARTICLE
Farah Aziz, Mohammad Fareed Khan, Amna Moiz
Gestational diabetes mellitus (GDM) is a known risk factor for gestational hypertension which further progress toward conditions like proteinuria, dyslipidemia, thrombocytopenia, pulmonary edema leading to Preeclampsia (PE). Pregnancy can be a challenging time for many women, especially those diagnosed with GDM and PE. Thus, the current prospective study investigates the association of OGTT glucose levels with systolic and diastolic blood pressure and lipid profile parameters in pregnant women diagnosed with GDM and PE...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38482278/antenatal-factors-and-risk-of-postpartum-hyperglycemia-in-women-with-gestational-diabetes-mellitus-a-central-india-prospective-cohort-study
#15
JOURNAL ARTICLE
Nilajkumar Bagde, Madhuri Bagde, Vijayalakshmi Shanbhag, Pragati Trigunait, Nagma Sheikh, Sarita Agrawal
INTRODUCTION: Global prevalence of gestational diabetes mellitus (GDM) ranges from <1% to 28%. Risk of postpartum diabetes (PPDM) is 7 times higher in women with GDM. We aimed to identify antenatal risk factors associated with postpartum hyperglycemia so that these women may be subjected to targeted screening in a low resource setting. METHODS: Screening for GDM was done with a 75gram GTT using IADPSG criteria in women between 28-29 weeks and post-partum screening for hyperglycemia was done using 75 gm 2hour OGTT...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38477665/metabolic-associated-fatty-liver-disease-is-characterized-by-a-post-oral-glucose-load-hyperinsulinemia-in-individuals-with-mild-metabolic-alterations
#16
JOURNAL ARTICLE
Théo Gignac, Gabrielle Trépanier, Marion Pradeau, Arianne Morissette, Anne-Laure Agrinier, Eric Larose, Julie Marois, Geneviève Pilon, Claudia Gagnon, Marie-Claude Vohl, André Marette, Anne-Marie Carreau
Metabolic-associated fatty liver disease (MAFLD) has been identified as risk factor of incident type 2 diabetes (T2D), but the underlying postprandial mechanisms remains unclear. We compared the glucose metabolism, insulin resistance, insulin secretion and insulin clearance post-oral glucose tolerance test (OGTT) between individuals with and without MAFLD. We included 50 individuals with a BMI between 25-40 kg/m2 and ≥1 metabolic alteration: increased fasting triglycerides or insulin, plasma glucose 5...
March 13, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38467551/serum-glycome-as-a-diagnostic-and-prognostic-factor-in-gestational-diabetes-mellitus
#17
JOURNAL ARTICLE
Ognjen Radojičić, Lucia Pažitná, Zorana Dobrijević, Paras Kundalia, Kristina Kianičková, Jaroslav Katrlík, Vesna Mandić Marković, Željko Miković, Olgica Nedić, Dragana Robajac
Gestational diabetes mellitus (GDM) is a risk factor for both mother and fetus/neonate during and after the pregnancy. Inconsistent protocols and cumbersome screening procedures warrant the search for new and easily accessible biomarkers. We investigated a potential of serum N-glycome to differentiate between healthy pregnant women (n = 49) and women with GDM (n = 53) using a lectin-based microarray and studied the correlation between the obtained data and parameters of glucose and lipid metabolism. Four out of 15 lectins used were able to detect the differences between the control and GDM groups in fucosylation, terminal galactose/N-acetylglucosamine (Gal/GlcNAc), presence of Galα1,4Galβ1,4Glc (Gb3 antigen), and terminal α2,3-sialylation with AUC values above 60%...
January 2024: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38467385/a-prospective-1-year-follow-up-of-glycemic-status-and-c-peptide-levels-of-covid-19-survivors-with-dysglycemia-in-acute-covid-19-infection
#18
JOURNAL ARTICLE
David Tak Wai Lui, Chi Ho Lee, Ying Wong, Carol Ho Yi Fong, Kimberly Hang Tsoi, Yu Cho Woo, Kathryn Choon Beng Tan
BACKGROUND: We evaluated changes in glycemic status, over 1 year, of coronavirus disease 2019 (COVID-19) survivors with dysglycemia in acute COVID-19. METHODS: COVID-19 survivors who had dysglycemia (defined by glycosylated hemoglobin [HbA1c] 5.7% to 6.4% or random glucose ≥10.0 mmol/L) in acute COVID-19 were recruited from a major COVID-19 treatment center from September to October 2020. Matched non-COVID controls were recruited from community. The 75-g oral glucose tolerance test (OGTT) were performed at baseline (6 weeks after acute COVID-19) and 1 year after acute COVID-19, with HbA1c, insulin and C-peptide measurements...
March 11, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38460576/red-ginseng-ameliorates-lipotoxicity-induced-renal-fibrosis-in-hyperuricemia-mice
#19
JOURNAL ARTICLE
Ying-Ling Zhang, Si-Min Chen, Yi-Jie Song, Ariful Islam, Pei-Li Rao, Meng-Jie Zhu, Wen-Yi Gu, Yu Xu, Hong-Xi Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic kidney disease can be caused by numerous diseases including obesity and hyperuricemia (HUA). Obesity may exacerbate the renal injury caused by HUA. Red ginseng, a steamed products of Panax ginseng Meyer root, is known for its remarkable efficacy in improving metabolic syndrome, such as maintaining lipid metabolic balance. However, the role of red ginseng on hyperuricemia-induced renal injury in obese cases remains unclear. AIM OF THE STUDY: This study aimed to investigate the action of red ginseng extract (RGE) on lipotoxicity-induced renal injury in HUA mice...
March 7, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38458916/international-diabetes-federation-position-statement-on-the-1-hour-post-load-plasma-glucose-for-the-diagnosis-of-intermediate-hyperglycaemia-and-type-2-diabetes
#20
JOURNAL ARTICLE
Michael Bergman, Melania Manco, Ilhan Satman, Juliana Chan, Maria Inês Schmidt, Giorgio Sesti, Teresa Vanessa Fiorentino, Muhammad Abdul-Ghani, Ram Jagannathan, Pramod Kumar Thyparambil Aravindakshan, Rafael Gabriel, Viswanathan Mohan, Martin Buysschaert, Abdullah Bennakhi, Andre Pascal Kengne, Brenda Dorcely, Peter M Nilsson, Tiinamaija Tuomi, Tadej Battelino, Akhtar Hussain, Antonio Ceriello, Jaakko Tuomilehto
Many individuals with intermediate hyperglycaemia (IH), including impaired fasting glycaemia (IFG) and impaired glucose tolerance (IGT), as presently defined, will progress to type 2 diabetes (T2D). There is confirmatory evidence that T2D can be prevented by lifestyle modification and/or medications, in people with IGT diagnosed by 2-h plasma glucose (PG) during a 75-gram oral glucose tolerance test (OGTT). Over the last 40 years, a wealth of epidemiological data has confirmed the superior value of 1-h plasma glucose (PG) over fasting PG (FPG), glycated haemoglobin (HbA1c ) and 2-h PG in populations of different ethnicity, sex and age in predicting diabetes and associated complications including death...
March 6, 2024: Diabetes Research and Clinical Practice
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