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infection control wounds

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https://www.readbyqxmd.com/read/28817451/relative-temperature-maximum-in-wound-infection-and-inflammation-as-compared-with-a-control-subject-using-long-wave-infrared-thermography
#1
Arjun Chanmugam, Diane Langemo, Korissa Thomason, Jaimee Haan, Elizabeth A Altenburger, Aletha Tippett, Linda Henderson, Todd A Zortman
OBJECTIVE: The purpose of this retrospective case series was to determine whether a long-wave infrared thermography (LWIT, or thermal imaging) camera can detect specific temperature changes that are associated with wound infection and inflammation as compared with normal control subjects with similar anatomical wound locations. DESIGN: A retrospective, observational, collective, multiple case series of patients who underwent digital and thermal imaging of wounds in various states...
September 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28816967/hand-assisted-laparoscopic-surgery-versus-conventional-open-surgery-in-intraoperative-and-postoperative-outcomes-for-colorectal-cancer-an-updated-systematic-review-and-meta-analysis
#2
Xubing Zhang, Qingbin Wu, Chaoyang Gu, Tao Hu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims to compare hand-assisted laparoscopic surgery (HALS) and conventional open surgery (OS) for colorectal cancer (CRC) in terms of intraoperative and postoperative outcomes, and to explore the safety, feasibility of HALS for CRC surgery. METHODS: A systematic literature search with no limits was performed in PubMed, Embase, and Medline. The last search was performed on April 23, 2017. The outcomes of interests included intraoperative outcomes (operative time, blood loss, length of incision, transfusion, and lymph nodes harvested), postoperative outcomes (length of hospital stay, length of postoperative hospital stay, time to first flatus, time to first liquid diet, time to first soft diet, time to first bowel movement, postoperative complications, reoperation, ileus, anastomotic leakage, wound infection, urinary complication, pulmonary infection, and mortality)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816717/comparison-of-negative-pressure-wound-therapy-and-conventional-therapy-for-cranial-bone-exposed-wounds-in-rabbits
#3
Lin Chen, Guorui Li, Sha Liu, Xianjie Ma, Xueyong Li, Yingjun Su, Shuzhong Guo
BACKGROUND: Bone-exposed wounds with intact or defected periosteum are difficult to heal. To provide relevant experimental evidence for guidance of clinical therapy, we established a rabbit model to compare the efficacies of negative pressure wound therapy (NPWT) and conventional guaze dressing therapy on the healing of cranial bone-exposed wounds. METHODS: Full-thickness excisional circular wounds of 2.0 cm in diameter with exposed bones covered with or without periosteum were created at the parietal regions in 88 rabbits that were further randomly divided into the following treatment groups: periosteum-intact wounds treated with conventional vaseline gauze dressings (P + Control group), periosteum-intact wounds treated with NPWT (P + NPWT group), periosteum-lacking wounds treated with conventional vaseline gauze dressings (P-Control group), and periosteum-lacking wounds treated with NPWT (P-NPWT group)...
August 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28813520/the-frequency-of-class1-and-2-integrons-in-pseudomonas-aeruginosa-strains-isolated-from-burn-patients-in-a-burn-center-of-ahvaz-iran
#4
Azar Dokht Khosravi, Moloudsadat Motahar, Effat Abbasi Montazeri
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen with the ability to cause severe nosocomial infections and remains a major problem in burn patients. This organism shows a remarkable antimicrobial resistance and is often resistant to multiple antibiotics. Integron genes as mobile genetic elements are playing an important role in the spread of P. aeruginosa antibiotic resistance. This study was aimed to investigate the occurrence of class 1, and 2 integron genes (int1, int2), among P...
2017: PloS One
https://www.readbyqxmd.com/read/28810620/ccaat-enhancer-binding-protein-%C3%AE-has-a-crucial-role-in-regulating-breast-cancer-cell-growth-via-activating-the-tgf-%C3%AE-smad3-signaling-pathway
#5
Jing Cao, Meng Wang, Tao Wang
The aim of the present study was to examine the effect of CCAAT enhancer binding protein β (C/EBPβ) on human breast cancer cells. The plasmids pCDH-C/EBPβ and pLKO.1-shC/EBPβ were constructed and were infected into MDA-MB-468 cells, to provide C/EBPβ overexpressing and C/EBPβ knockdown cells, respectively. Cell viability, cell cycle and apoptosis were observed by MTT assay and flow cytometry analysis. Protein expression levels of C/EBPβ, TGF-β1, P-Smad3 and Smad3 were detected by western blotting. MTT assay showed that the absorbance of MDA-MB-468 cells in the pCDH-C/EBPβ group was increased, whereas that in the pLKO...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809421/-reactive-nano-complex-coated-medical-cotton-a-facile-avenue-for-tailored-release-of-small-molecules
#6
Adil Majeed Rather, Sulendar Mahato, Kousik Maji, Neeha Gogoi, Uttam Manna
Controlled and sustained release of drug-like small molecules in an aqueous medium still remains a challenging problem due to rapid infiltration of liquid water in most reported drug release systems. However, internal-superhydrophobicity with an antifouling property extending beyond the surface of a material recently has been recognized as a potential avenue for sustained and extended release of drug-like small molecules. Sluggish removal of metastable trapped air in a superhyrophobic material provides a basis to achieve extended release of encapsulated small molecules...
August 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28806288/acellular-dermal-matrix-in-immediate-expander-implant-breast-reconstruction-a-multicenter-assessment-of-risks-and-benefits
#7
Michael Sorkin, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Jeffrey H Kozlow, Andrea L Pusic, Edwin G Wilkins
INTRODUCTION: Acellular dermal matrix (ADM) has gained widespread acceptance in immediate expander/implant reconstruction due to perceived benefits, including improved expansion dynamics and superior aesthetic results. Although previous investigators have evaluated its risks, few studies have assessed the impact of ADM on other outcomes, including patient-reported measures. METHODS: The Mastectomy Reconstruction Outcomes Consortium (MROC) Study used a prospective cohort design to evaluate patients undergoing post-mastectomy reconstruction from 10 centers and 58 participating surgeons between 2012 and 2015...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28802983/systemic-and-local-management-of-burn-wounds
#8
REVIEW
Alessio Vigani, Christine A Culler
Management of severe burn injury (SBI) requires prompt, complex, and aggressive care. Despite major advances in the management of SBI-including patient-targeted resuscitation, management of inhalation injuries, specific nutritional support, enhanced wound therapy, and infection control-the consequences of SBI often result in complex, multiorgan metabolic changes. Consensus guidelines and clinical evidence regarding specific management of small animal burn patients are lacking. This article aims to review updated therapeutic consideration for the systemic and local management of SBI that are proven effective to optimize outcomes in human burn patients and may translate to small animal patients...
August 9, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28802182/inflammatory-markers-as-risk-factors-for-infection-with-multidrug-resistant-microbes-in-diabetic-foot-subjects
#9
Saba Noor, Abhijit Girish Borse, Maaz Ozair, Alok Raghav, Iqbal Parwez, Jamal Ahmad
BACKGROUND: Diabetic foot ulcers (DFUs), a dreadful microvascular complication of diabetes is responsible for substantial increase in morbidity and mortality. Infection, not a cause, but a consequence in DFUs that accounts for minor or major limb loss. The current study aimed to evaluate the microbial etiology of infected diabetic foot ulcers in northern tertiary care hospital, assessment of risk factors and role of inflammatory markers involved in colonization of multidrug-resistant organisms (MDROs) and their impact on the outcome...
May 3, 2017: Foot
https://www.readbyqxmd.com/read/28799757/immobilization-of-growth-factors-to-collagen-surfaces-using-visible-light
#10
Gabriella Maria Fernandes Cunha, Hyun Jong Lee, Alisha Kumar, Alexander Kreymerman, Sarah Christine Heilshorn, David Myung
In the treatment of traumatic injuries, burns, and ulcers of the eye, inadequate epithelial tissue healing remains a major challenge. Wound healing is a complex process involving the temporal and spatial interplay between cells and their extracellular milieu. It can be impaired by a variety of causes including infection, poor circulation, loss of critical cells and/or proteins, and a deficiency in normal neural signaling (e.g. neurotrophic ulcers). Ocular anatomy is particularly vulnerable to lasting morbidity from delayed healing, whether it be scarring or perforation of the cornea, destruction of the conjunctival mucous membrane, or cicatricial changes to the eyelids and surrounding skin...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28796687/comparison-of-subcuticular-suture-type-for-skin-closure-after-cesarean-delivery-a-randomized-controlled-trial
#11
Arin M Buresch, Anne Van Arsdale, Myriam Ferzli, Nicole Sahasrabudhe, Mengyang Sun, Jeffrey Bernstein, Peter S Bernstein, Ivan M Ngai, David J Garry
OBJECTIVE: To compare the rate of wound complications among women who underwent cesarean delivery through a Pfannenstiel skin incision followed by subcuticular closure with either poliglecaprone 25 suture or polyglactin 910 suture. METHODS: Patients undergoing nonemergent cesarean delivery at or beyond 37 weeks of gestation were randomized to undergo subcuticular skin closure with either poliglecaprone 25 or polyglactin 910. The primary outcome was a wound composite outcome of one or more of the following: surgical site infection, wound separation, hematoma, or seroma within the first 30 days postpartum...
August 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796014/comparison-of-superficial-surgical-site-infection-between-delayed-primary-versus-primary-wound-closure-in-complicated-appendicitis-a-randomized-controlled-trial
#12
Boonying Siribumrungwong, Anuwat Chantip, Pinit Noorit, Chumpon Wilasrusmee, Winai Ungpinitpong, Pradya Chotiya, Borwornsom Leerapan, Patarawan Woratanarat, Mark McEvoy, John Attia, Ammarin Thakkinstian
OBJECTIVE: To compare superficial surgical site infection (SSI) rates between delayed primary wound closure (DPC) and primary wound closure (PC) for complicated appendicitis. BACKGROUND: SSI is common in appendectomy for complicated appendicitis. DPC is preferentially used over PC, but its efficacy is still controversial. METHODS: A multicenter randomized controlled trial was conducted in 6 hospitals in Thailand, enrolling patients with gangrenous and ruptured appendicitis...
August 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28795673/-under-expression-of-lats1-promotes-the-differentiation-proliferation-and-migration-of-mesenchymal-stem-cells-by-inhibition-the-hippo-signaling-pathway-in-vitro
#13
Lang Li, Liang Dong, Jiaojie Hui, Fei Gao, Qiuhui Wang, Lan Yang, Jiangqian Zhang, Jie Yan
OBJECTIVE: To explore the effects of under-expression of large tumor suppressor 1 (LATS1) on activation of Hippo signaling pathway and differentiation, proliferation, migration of bone marrow mesenchymal stem cells (mMSCs) of mice in vitro. METHODS: mMSCs of C57BL/6 mice were divided into normal control (MSC) group, empty vector control (MSC-GFP) group, LATS1-over-expressing (MSC-LATS1) group, empty vector without LATS1 shRNA control (MSC-shControl) group and LATS1-under-expressing (MSC-shLATS1) group...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28790237/-prophylactic-effectiveness-of-vacuum-assisted-closure-for-high-risk-patients-undergoing-cardiovascular-surgery-through-median-sternotomy
#14
Ippei Takazawa, Yoshio Misawa, Satoshi Uesugi, Akira Sugaya, Hirohiko Akutsu, Souki Kurumisawa, Hirotaka Satoh, Arata Muraoka, Kei Aizawa, Shinichi Ohki, Koji Kawahito
Vacuum-assisted closure(VAC) therapy is mainly used for tissue defects. VAC therapy can remove exudate that could impair the healing process. We applied VAC therapy in patients considered at high risk of surgical site infection who underwent cardiovascular surgery via standard median sternotomy. Risk factors included advanced heart failure, obesity, diabetes mellitus, steroid administration, immunosuppressant administration, and chronic renal failure, etc. VAC therapy was used in 134 patients. Only 3 of these patients (2...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28777284/outcomes-of-primary-posterior-spinal-fusion-for-scoliosis-in-spinal-muscular-atrophy-clinical-radiographic-and-pulmonary-outcomes-and-complications
#15
Joshua B Holt, Lori A Dolan, Stuart L Weinstein
BACKGROUND: Spinal muscular atrophy (SMA) is a progressive neuromuscular disease commonly including progressive scoliosis resulting in severe deformity and negatively affecting pulmonary function. Surgical correction and stabilization of this progressive deformity is generally recommended; however, the timing and method of surgical fixation remains controversial. METHODS: Retrospective review of clinical, radiographic, and pulmonary function data from 16 children with SMA and surgically treated scoliosis between 1985 and 2013...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28777282/intrawound-vancomycin-powder-associated-with-reduced-surgical-site-infection-in-rib-based-distraction-surgery
#16
Justin M Haller, John A Heflin, David A Hulet, Qian Ding, Angela P Presson, John T Smith
BACKGROUND: Despite clinical reports of improved pulmonary function and reduced spinal deformity with rib-based distraction surgery in early-onset scoliosis (EOS) patients, infection remains a common complication, reported as high as 32% in some studies. The purpose of this study was to evaluate intrawound vancomycin powder in pediatric patients managed with rib-based distraction for EOS. METHODS: This was a single institution retrospective cohort study of EOS patients treated with rib-based distraction...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28771993/a-pegylated-fibrin-hydrogel-based-antimicrobial-wound-dressing-controls-infection-without-impeding-wound-healing
#17
Joel Gil, Shanmugasundaram Natesan, Jie Li, Jose Valdes, Andrew Harding, Michael Solis, Stephen C Davis, Robert J Christy
Combat injuries are associated with a high incidence of infection, and there is a continuing need for improved approaches to control infection and promote wound healing. Due to the possible local and systemic adverse effects of standard 1% cream formulation (Silvadene), we had previously developed a polyethylene glycol (PEGylated) fibrin hydrogel (FPEG)-based wound dressing for the controlled delivery of silver sulfadiazine (SSD) entrapped in chitosan microspheres (CSM). In this study, we have evaluated the antimicrobial and wound healing efficacy of SSD-CSM-FPEG using a full-thickness porcine wound infected with Pseudomonas aeruginosa...
August 2, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28770482/a-minimally-invasive-approach-for-inguinal-lymphadenectomy-in-melanoma-and-genitourinary-malignancy-long-term-outcomes-in-an-attempted-randomized-control-trial
#18
Lauren M Postlewait, Clara R Farley, Maggie L Diller, Benjamin Martin, M Hart Squires, Maria C Russell, Monica Rizzo, Kenneth Ogan, Viraj Master, Keith Delman
BACKGROUND: Open inguinal lymphadenectomy (OIL) has a high incidence of complications. The authors adapted and reported a minimally invasive technique [videoscopic inguinal lymphadenectomy (VIL)] for use with melanoma, subsequently pursuing a randomized, prospective trial comparing open and minimally invasive approaches in an attempt to confirm retrospective findings illustrating reduced complications with the minimally invasive approach. METHODS: A randomized, prospective trial (NCT01526486) was designed to compare outcomes for patients undergoing VIL versus OIL...
August 2, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28765796/the-effects-of-topical-vancomycin-on-mesenchymal-stem-cells-more-may-not-be-better
#19
Stacey Chu, Nita Chen, Alexis B C Dang, Alfred C Kuo, Alan B C Dang
BACKGROUND: The use of topical vancomycin is increasingly popular in spine surgery. Large retrospective reviews suggest that topical vancomycin provides a cost-effective decrease in post-operative infection. Currently, there is little that is known about the maximum dose that can be applied locally. When 1 gram of vancomycin is mixed into the bone graft and another 1 gram applied freely in a spine wound, the local concentration of antibiotic ranges from 260-2900 μg/mL in the immediate post-op period and 50-730 μg/mL by the second post-operative day...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28763892/-efficacy-and-safety-of-drainage-after-total-knee-arthroplasty
#20
F Jing, H M Li, X D Yang, B Li, J Ji, Y L Li, C J Sun
Objective: To determine whether suction drainage is safe and effective compared with no-drainage in total knee arthroplasty. Methods: The literature search was based on PubMed, MEDLINE, EMBASE, Highwire, the Cochrane Library, CBM, CNKI, VIP and WFSD.The data were analysed using RevMan 5.3.Fourteen randomised controlled trials involving 1 009 knees were included in our analysis. Results: Suction drainage increases the rate and volume of blood transfusion.No-drainage group increases the rate of wound problems (OR=1...
July 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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