Amee M Bigelow, Kyle W Riggs, David L S Morales, Alexander R Opotowsky, Adam M Lubert, Jonathan R Dillman, Gruschen R Veldtman, Haleh C Heydarian, Andrew T Trout, David S Cooper, Stuart L Goldstein, Clifford Chin, Joseph J Palermo, Nicholas J Ollberding, Wayne A Mays, Tarek Alsaied
After Fontan operation, decreased venous capacitance and venoconstriction are adaptive mechanisms to maintain venous return and cardiac output. The consequent higher venous pressure may adversely impact end-organ function, exercise capacity and result in worse clinical outcomes. This pilot study evaluated the safety and effect of isosorbide dinitrate (ISDN), a venodilator, on exercise capacity, peripheral venous pressure (PVP), and liver stiffness in patients with Fontan circulation. In this prospective single-arm trial, 15 individuals with Fontan circulation were evaluated at baseline and after 4 weeks of therapeutic treatment with ISDN...
April 21, 2023: Pediatric Cardiology