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https://www.readbyqxmd.com/read/28205535/phylogenetic-analysis-of-eukaryotic-neet-proteins-uncovers-a-link-between-a-key-gene-duplication-event-and-the-evolution-of-vertebrates
#1
Madhuri A Inupakutika, Soham Sengupta, Rachel Nechushtai, Patricia A Jennings, Jose' N Onuchic, Rajeev K Azad, Pamela Padilla, Ron Mittler
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the "NEET" motif. They are involved in the regulation of iron and reactive oxygen metabolism, and have been associated with the progression of diabetes, cancer, aging and neurodegenerative diseases. Despite their important biological functions, the evolution and diversification of eukaryotic NEET proteins are largely unknown. Here we used the three members of the human NEET protein family (CISD1, mitoNEET; CISD2, NAF-1 or Miner 1; and CISD3, Miner2) as our guides to conduct a phylogenetic analysis of eukaryotic NEET proteins and their evolution...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195537/-exit-exams-for-medical-graduates-a-guarantee-of-quality
#2
Ranjit Kumar Dehury, Janmejaya Samal
Despite a great deal of opposition from many segments of the medical community, the Medical Council of India (MCI) has proposed to the Ministry of Health and Family Welfare, Government of India that a pan-India exit examination be introduced for graduating MBBS doctors. Whether the proposal should be put forward was considered twice, once in 2010 and again in 2013, and finally the plan was ready to be taken forward seriously in 2015. The proposal has elicited appreciation and criticism from different segments of the medical community...
January 12, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28175944/erratum-to-a-prospective-cohort-study-of-depression-course-functional-disability-and-neet-status-in-help-seeking-young-adults
#3
Bridianne O'Dea, Rico S C Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykletun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
No abstract text is available yet for this article.
February 7, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28122584/are-we-failing-young-people-not-in-employment-education-or-training-neets-a-systematic-review-and-meta-analysis-of-re-engagement-interventions
#4
Lauren Mawn, Emily J Oliver, Nasima Akhter, Clare L Bambra, Carole Torgerson, Chris Bridle, Helen J Stain
BACKGROUND: Youth comprise 40% of the world's unemployed, a status associated with adverse wellbeing and social, health, and economic costs. This systematic review and meta-analysis review synthesises the literature on the effectiveness of interventions targeting young people not in employment, education, or training (NEET). METHODS: Randomised and quasi-randomised trials with a concurrent or counterfactual control group and baseline equivalence are included. Cochrane collaboration tools are used to assess quality, and a narrative synthesis was undertaken...
January 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/27994115/child-maltreatment-and-adult-living-standards-at-50-years
#5
Snehal M Pinto Pereira, Leah Li, Chris Power
BACKGROUND AND OBJECTIVE: Child maltreatment (abuse and neglect) has established effects on mental health. Less is known about its influence on adult economic circumstances. We aimed to establish associations of child maltreatment with such outcomes and explore potential pathways. METHODS: We used 1958 British birth cohort data (N = 8076) to examine associations of child neglect and abuse with adult (50 years) long-term sickness absence, not in employment, education or training (NEET), lacking assets, income-related support, poor qualifications, financial insecurity, manual social class, and social mobility...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27808067/re-entry-neet-national-eligibility-cum-entrance-test-opportunity-and-concerns
#6
Avinash Supe, Tejinder Singh
No abstract text is available yet for this article.
May 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/27793548/gender-inequality-and-violence-against-women-in-spain-2006-2014-towards-a-civilized-society
#7
Erika M Redding, María Teresa Ruiz-Cantero, José Fernández-Sáez, Marta Guijarro-Garvi
OBJECTIVE: Considering both the economic crisis of 2008 and the Gender Equality Law (2007), this study analyses the association between gender inequality in Spanish Autonomous Communities (AC) and intimate partner violence (IPV) from 2006 to 2014 in terms of socio-demographic characteristics. METHODS: Ecological study in the 17 Spanish AC on the correlation between the reported cases by IPV and deaths and the Gender Inequality Index and its dimensions: empowerment, participation in the labour market and adolescent birth rates; and their correlation with Young People Not in Education, Employment or Training (NEET)...
October 26, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27734591/the-relapse-rate-and-predictors-of-relapse-in-patients-with-first-episode-psychosis-following-discontinuation-of-antipsychotic-medication
#8
Suzanne Di Capite, Rachel Upthegrove, Pavan Mallikarjun
BACKGROUND: To determine the "real world" relapse rate in patients with first-episode psychosis (FEP) who had discontinued antipsychotic medication and identify socio-demographic and clinical factors associated with the risk of relapse. METHODS: Quantitative data were obtained via case-note review on 63 patients with FEP who had discontinued antipsychotic medication from Birmingham Early Intervention Service between 2012 and 2015. The follow-up period was until either: an occurrence of a relapse; end of 12-month study period; end of patient's case-note record...
October 13, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27498112/a-prospective-cohort-study-of-depression-course-functional-disability-and-neet-status-in-help-seeking-young-adults
#9
Bridianne O'Dea, Rico S C Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) status in a clinical sample of young adults with mental health problems. METHODS: Young adults aged 15-25 years seeking help from four primary mental health services were invited to participate in a prospective cohort study evaluating the course of psychiatric disorders in youth. Demographic and clinical characteristics, including depressive symptomatology and functioning, were evaluated through clinical interview and self-report at baseline and 12 month follow-up...
October 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27488542/neet-india-s-single-exam-for-admission-to-medical-school-promises-transparency-and-quality
#10
Avinash Supe
No abstract text is available yet for this article.
August 3, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27247659/young-italian-neets-not-in-employment-education-or-training-and-the-influence-of-their-family-background
#11
Sara Alfieri, Emiliano Sironi, Elena Marta, Alessandro Rosina, Daniela Marzana
This work investigates the relationship between family variables (parents' educational level, relationship quality, intrusiveness, support, and autonomy) and young Italians' status as NEETs (Not in Employment, Education, or Training). We used data from a representative sample of 9,087 young Italians. Each participant filled out an anonymous online questionnaire that contained several scales to measure the variables mentioned above. The results reveal that parents' educational level and support have a protective effect on the risk of becoming a NEET for both genders...
May 2015: Europe's journal of psychology
https://www.readbyqxmd.com/read/27242651/the-ecology-of-withdrawal-commentary-the-neet-and-hikikomori-spectrum-assessing-the-risks-and-consequences-of-becoming-culturally-marginalized
#12
Michael E W Varnum, Jung Y Kwon
No abstract text is available yet for this article.
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27222393/a-neet-way-to-impair-mitochondrial-function-in-%C3%AE-and-%C3%AE-cells
#13
Changhong Li, Joseph A Baur
No abstract text is available yet for this article.
June 2016: Diabetes
https://www.readbyqxmd.com/read/26929142/the-coat-protein-of-alfalfa-mosaic-virus-interacts-and-interferes-with-the-transcriptional-activity-of-the-bhlh-transcription-factor-ilr3-promoting-salicylic-dependent-defense-signaling-response
#14
Frederic Aparicio, Vicente Pallás
During virus infection, the specific viral components-host factors interaction elicits transcriptional reprogramming of diverse cellular pathways. Alfalfa mosaic virus (AMV) establishes a compatible interaction in tobacco and Arabidopsis hosts. We show that the coat protein (CP) of AMV directly interacted with transcription factor (TF) ILR3 of both species. ILR3 is a basic helix-loop-helix (bHLH) family member of TFs, previously proposed to participate in diverse metabolic pathways. ILR3 has been shown to regulate NEET in Arabidopsis, a critical protein in plant development, senescence, iron metabolism and reactive oxygen species (ROS) homeostasis...
February 29, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/26927619/mental-health-improves-after-transition-from-comprehensive-school-to-vocational-education-or-employment-in-england-a-national-cohort-study
#15
Jennifer Symonds, Julia Dietrich, Angela Chow, Katariina Salmela-Aro
Underpinned by stage-environment fit and job demands-resources theories, this study examined how adolescents' anxiety, depressive symptoms, and positive functioning developed as they transferred from comprehensive school to further education, employment or training, or became NEET (not in education, employment, or training), at age 16 years, in the longitudinal English national cohort study Next Steps (N = 13,342). Controlling for childhood achievement, socioeconomic status, ethnicity, and gender, we found that NEET adolescents had the largest losses in mental health...
April 2016: Developmental Psychology
https://www.readbyqxmd.com/read/26791344/committed-to-work-but-vulnerable-self-perceptions-and-mental-health-in-neet-18-year-olds-from-a-contemporary-british-cohort
#16
Sidra Goldman-Mellor, Avshalom Caspi, Louise Arseneault, Nifemi Ajala, Antony Ambler, Andrea Danese, Helen Fisher, Abigail Hucker, Candice Odgers, Teresa Williams, Chloe Wong, Terrie E Moffitt
BACKGROUND: Labour market disengagement among youths has lasting negative economic and social consequences, yet is poorly understood. We compared four types of work-related self-perceptions, as well as vulnerability to mental health and substance abuse problems, among youths not in education, employment or training (NEET) and among their peers. METHODS: Participants were from the Environmental Risk (E-Risk) longitudinal study, a nationally representative UK cohort of 2,232 twins born in 1994-1995...
February 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/26448442/cancer-related-neet-proteins-transfer-2fe-2s-clusters-to-anamorsin-a-protein-required-for-cytosolic-iron-sulfur-cluster-biogenesis
#17
Colin H Lipper, Mark L Paddock, José N Onuchic, Ron Mittler, Rachel Nechushtai, Patricia A Jennings
Iron-sulfur cluster biogenesis is executed by distinct protein assembly systems. Mammals have two systems, the mitochondrial Fe-S cluster assembly system (ISC) and the cytosolic assembly system (CIA), that are connected by an unknown mechanism. The human members of the NEET family of 2Fe-2S proteins, nutrient-deprivation autophagy factor-1 (NAF-1) and mitoNEET (mNT), are located at the interface between the mitochondria and the cytosol. These proteins have been implicated in cancer cell proliferation, and they can transfer their 2Fe-2S clusters to a standard apo-acceptor protein...
2015: PloS One
https://www.readbyqxmd.com/read/26347667/the-neet-and-hikikomori-spectrum-assessing-the-risks-and-consequences-of-becoming-culturally-marginalized
#18
Yukiko Uchida, Vinai Norasakkunkit
An increasing number of young people are becoming socially and economically marginalized in Japan under economic stagnation and pressures to be more globally competitive in a post-industrial economy. The phenomena of NEET/Hikikomori (occupational/social withdrawal) have attracted global attention in recent years. Though the behavioral symptoms of NEET and Hikikomori can be differentiated, some commonalities in psychological features can be found. Specifically, we believe that both NEET and Hikikomori show psychological tendencies that deviate from those governed by mainstream cultural attitudes, values, and behaviors, with the difference between NEET and Hikikomori being largely a matter of degree...
2015: Frontiers in Psychology
https://www.readbyqxmd.com/read/25918452/pobreza-y-vulnerabilidad-en-m%C3%A3-xico-el-caso-de-los-j%C3%A3-venes-que-no-estudian-ni-trabajan
#19
Emma Aguila, Nelly Mejía, Francisco Pérez, Alfonso Rivera, Edgar Ramírez
Recently, the phenomenon of young people not in education, employment or training (NEET) has come to the fore due to the risks associated to this situation. The contribution of this paper is in its analysis of this population's composition, dynamics, poverty patterns, individual and family characteristics, as well as projections for 2030. In addition, we propose a classification for NEET's that could be used for the design of public policies and that was used to identify that this population will tend to decreased due to the proportion of women who study and join the labor force and that, in the future, the unemployed will outnumber other groups...
June 2015: Estudios Económicos
https://www.readbyqxmd.com/read/25762074/the-fe-s-cluster-containing-neet-proteins-mitoneet-and-naf-1-as-chemotherapeutic-targets-in-breast-cancer
#20
Fang Bai, Faruck Morcos, Yang-Sung Sohn, Merav Darash-Yahana, Celso O Rezende, Colin H Lipper, Mark L Paddock, Luhua Song, Yuting Luo, Sarah H Holt, Sagi Tamir, Emmanuel A Theodorakis, Patricia A Jennings, José N Onuchic, Ron Mittler, Rachel Nechushtai
Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S proteins, mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1), recently implicated in cancer cell proliferation. Docking analysis of MAD-28 to mNT/NAF-1 revealed that in contrast to CLV, which formed a hydrogen bond network that stabilized the 2Fe-2S clusters of these proteins, MAD-28 broke the coordinative bond between the His ligand and the cluster's Fe of mNT/NAF-1...
March 24, 2015: Proceedings of the National Academy of Sciences of the United States of America
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