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https://www.readbyqxmd.com/read/29916431/the-national-licentiate-examination-pros-and-cons
#1
Rajiv Mahajan, Tejinder Singh
A multiple choice-based National Eligibility-cum-Entrance Test for admission to postgraduate courses (NEET-PG) for 201 7 was conducted by the National Board of Examinations of India. It was widely reported in the media and through gazette notifications that the government is going to use this NEET examination as a licentiate examination in the near future. Medical students will be certified to practise in India only if they qualify in this examination. We discuss the pros and cons of such an end-of-term examination, its utility and educational impact besides proposing a comprehensive framework for implementing formative assessment in medical colleges...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29662496/assembly-and-transfer-of-iron-sulfur-clusters-in-the-plastid
#2
REVIEW
Yan Lu
Iron-Sulfur (Fe-S) clusters and proteins are essential to many growth and developmental processes. In plants, they exist in the plastids, mitochondria, cytosol, and nucleus. Six types of Fe-S clusters are found in the plastid: classic 2Fe-2S, NEET-type 2Fe-2S, Rieske-type 2Fe-2S, 3Fe-4S, 4Fe-4S, and siroheme 4Fe-4S. Classic, NEET-type, and Rieske-type 2Fe-2S clusters have the same 2Fe-2S core; similarly, common and siroheme 4Fe-4S clusters have the same 4Fe-4S core. Plastidial Fe-S clusters are assembled by the sulfur mobilization (SUF) pathway, which contains cysteine desulfurase (EC 2...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29615474/how-adolescent-health-influences-education-and-employment-investigating-longitudinal-associations-and-mechanisms
#3
Daniel R Hale, Russell M Viner
BACKGROUND: Education is recognised as a strong determinant of health. Yet there is increasing concern that health in adolescence may also influence educational attainments and future life chances. We examined associations between health in early adolescence and subsequent academic and employment outcomes, exploring potential mediators of these relationships to inform intervention strategies. METHODS: We used data from the Longitudinal Study of Young People in England...
June 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29463105/neet-proteins-a-new-link-between-iron-metabolism-reactive-oxygen-species-and-cancer
#4
Ron Mittler, Merav Darash-Yahana, Yang Sung Sohn, Fang Bai, Luhua Song, Ioav Z Cabantchik, Patricia A Jennings, José N Onuchic, Rachel Nechushtai
SIGNIFICANCE: Cancer cells accumulate high levels of iron and reactive oxygen species (ROS) to promote their high metabolic activity and proliferation rate. However, high levels of iron and ROS can also lead to enhanced oxidative stress and the activation of cell death pathways such as apoptosis and ferroptosis. This has led to the proposal that different drugs that target iron and/or ROS metabolism could be used as anticancer drugs. However, due to the complex role iron and ROS play in cells, the majority of these drugs yielded mixed results, highlighting a critical need to identify new players in the regulation of iron and ROS homeostasis in cancer cells...
March 29, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29435647/the-unique-fold-and-lability-of-the-2fe-2s-clusters-of-neet-proteins-mediate-their-key-functions-in-health-and-disease
#5
REVIEW
Ola Karmi, Henri-Baptiste Marjault, Luca Pesce, Paolo Carloni, Jose' N Onuchic, Patricia A Jennings, Ron Mittler, Rachel Nechushtai
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient-deprivation autophagy factor-1 (NAF-1) and cisd3 encodes MiNT (Miner2). These recently discovered proteins play key roles in many processes related to normal metabolism and disease. Indeed, NEET proteins are involved in iron, Fe-S, and reactive oxygen homeostasis in cells and play an important role in regulating apoptosis and autophagy. mNT and NAF-1 are homodimeric and reside on the outer mitochondrial membrane...
February 12, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29259115/structure-of-the-human-monomeric-neet-protein-mint-and-its-role-in-regulating-iron-and-reactive-oxygen-species-in-cancer-cells
#6
Colin H Lipper, Ola Karmi, Yang Sung Sohn, Merav Darash-Yahana, Heiko Lammert, Luhua Song, Amy Liu, Ron Mittler, Rachel Nechushtai, José N Onuchic, Patricia A Jennings
The NEET family is a relatively new class of three related [2Fe-2S] proteins (CISD1-3), important in human health and disease. While there has been growing interest in the homodimeric gene products of CISD1 (mitoNEET) and CISD2 (NAF-1), the importance of the inner mitochondrial CISD3 protein has only recently been recognized in cancer. The CISD3 gene encodes for a monomeric protein that contains two [2Fe-2S] CDGSH motifs, which we term mitochondrial inner NEET protein (MiNT). It folds with a pseudosymmetrical fold that provides a hydrophobic motif on one side and a relatively hydrophilic surface on the diametrically opposed surface...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29238319/evaluating-distal-and-proximal-explanations-for-withdrawal-a-rejoinder-to-varnum-and-kwon-s-the-ecology-of-withdrawal
#7
Vinai Norasakkunkit, Yukiko Uchida, Kosuke Takemura
In their 2016 commentary on our theorizing about how youth withdrawal from economic and social participation in Japanese society (i.e., NEET and Hikikomori phenomena) stems from generational inequality of economic opportunities, Varnum and Kwon correctly point out that our explanation for withdrawal is yet untested. They then offered an alternative, evolutionary psychological explanation for withdrawal in which they claim that in resource-rich ecologies like Japan, the option to withdraw from participating in society is a possible life strategy, a strategy that would be much more costly in resource-poor ecologies...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28959452/predicting-early-transition-from-sub-syndromal-presentations-to-major-mental-disorders
#8
Shane P M Cross, Jan Scott, Ian B Hickie
BACKGROUND: Transition from at-risk state to full syndromal mental disorders is underexplored for unipolar and bipolar disorders compared with psychosis. AIMS: Prospective, trans-diagnostic study of rates and predictors of early transition from sub-threshold to full syndromal mental disorder. METHOD: One-year outcome of 243 consenting youth aged 15-25 years with a sub-syndromal presentation of a potentially severe mental disorder. Survival analysis and odds ratio (OR) for predictors of transition identified from baseline clinical and demographic ratings...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/28951382/comparison-of-self-reported-telephone-interviewing-and-web-based-survey-responses-findings-from-the-second-australian-young-and-well-national-survey
#9
Alyssa C Milton, Louise A Ellis, Tracey A Davenport, Jane M Burns, Ian B Hickie
BACKGROUND: Web-based self-report surveying has increased in popularity, as it can rapidly yield large samples at a low cost. Despite this increase in popularity, in the area of youth mental health, there is a distinct lack of research comparing the results of Web-based self-report surveys with the more traditional and widely accepted computer-assisted telephone interviewing (CATI). OBJECTIVE: The Second Australian Young and Well National Survey 2014 sought to compare differences in respondent response patterns using matched items on CATI versus a Web-based self-report survey...
September 26, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28874224/adolescent-mental-health-and-behavioural-predictors-of-being-neet-a-prospective-study-of-young-adults-not-in-employment-education-or-training
#10
L Rodwell, H Romaniuk, W Nilsen, J B Carlin, K J Lee, G C Patton
BACKGROUND: Young adults who are not in employment, education, or training (NEET) are at risk of long-term economic disadvantage and social exclusion. Knowledge about risk factors for being NEET largely comes from cross-sectional studies of vulnerable individuals. Using data collected over a 10-year period, we examined adolescent predictors of being NEET in young adulthood. METHODS: We used data on 1938 participants from the Victorian Adolescent Health Cohort Study, a community-based longitudinal study of adolescents in Victoria, Australia...
April 2018: Psychological Medicine
https://www.readbyqxmd.com/read/28528425/neet-adolescents-grown-up-eight-year-longitudinal-follow-up-of-education-employment-and-mental-health-from-adolescence-to-early-adulthood-in-mexico-city
#11
Raúl A Gutiérrez-García, Corina Benjet, Guilherme Borges, Enrique Méndez Ríos, María Elena Medina-Mora
The purpose is to examine the socio-demographic and mental health outcomes in early adulthood of those who as adolescents were not in education, employment or training, termed NEET, compared to their counterparts who studied, worked, or both. One thousand and seventy-one youth residing in Mexico City participated in a representative, prospective, longitudinal 8-year two-Wave cohort study. At Wave I the participants were aged 12-17 and at Wave II aged 19 and 26. The Composite International Diagnostic Interview assessed psychiatric disorders, substance use and abuse, suicidal behavior, interpersonal relationships, employment and education...
December 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28433462/-health-and-access-to-health-care-of-18-25%C3%A2-years-old-people-not-in-employment-education-or-training-neets-attending-the-french-missions-locales
#12
S Robert, S Lesieur, J Chastang, V Kergoat, J Dutertre, P Chauvin
BACKGROUND: In France, "missions locales" are public assistance units for young people aged 16-25 years not in employment, education or training (NEET). The health status of the more than 1.5 million young adults attending these units annually is unknown. The purpose of this study was to describe the health status and health care use of this population in comparison with the general population of the same age. METHODS: The Presaje survey was conducted in 2011 on a randomized sample of 1453 young adults aged 18-25 years who attended five "missions locales" in mainland France...
August 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28426722/interactions-between-mitoneet-and-naf-1-in-cells
#13
Ola Karmi, Sarah H Holt, Luhua Song, Sagi Tamir, Yuting Luo, Fang Bai, Ammar Adenwalla, Merav Darash-Yahana, Yang-Sung Sohn, Patricia A Jennings, Rajeev K Azad, Jose' N Onuchic, Faruck Morcos, Rachel Nechushtai, Ron Mittler
The NEET proteins mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1) are required for cancer cell proliferation and resistance to oxidative stress. NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging. Previous studies suggested that mNT and NAF-1 could function in the same pathway in mammalian cells, preventing the over-accumulation of iron and reactive oxygen species (ROS) in mitochondria...
2017: PloS One
https://www.readbyqxmd.com/read/28425481/differences-in-salicylic-acid-glucose-conjugations-by-ugt74f1-and-ugt74f2-from-arabidopsis-thaliana
#14
Alayna M George Thompson, Cristina V Iancu, Kenneth E Neet, John V Dean, Jun-Yong Choe
Salicylic acid (SA) is a signaling molecule utilized by plants in response to various stresses. Through conjugation with small organic molecules such as glucose, an inactive form of SA is generated which can be transported into and stored in plant vacuoles. In the model organism Arabidopsis thaliana, SA glucose conjugates are formed by two homologous enzymes (UGT74F1 and UGT74F2) that transfer glucose from UDP-glucose to SA. Despite being 77% identical and with conserved active site residues, these enzymes catalyze the formation of different products: UGT74F1 forms salicylic acid glucoside (SAG), while UGT74F2 forms primarily salicylic acid glucose ester (SGE)...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393749/a-transdiagnostic-study-of-education-employment-and-training-outcomes-in-young-people-with-mental-illness
#15
R S C Lee, D F Hermens, J Scott, B O'Dea, N Glozier, E M Scott, I B Hickie
BACKGROUND: Optimizing functional recovery in young individuals with severe mental illness constitutes a major healthcare priority. The current study sought to quantify the cognitive and clinical factors underpinning academic and vocational engagement in a transdiagnostic and prospective youth mental health cohort. The primary outcome measure was 'not in education, employment or training' ('NEET') status. METHOD: A clinical sample of psychiatric out-patients aged 15-25 years (n = 163) was assessed at two time points, on average, 24 months apart...
September 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28253843/cancer-related-health-behaviours-of-young-people-not-in-education-employment-or-training-neet-a-cross-sectional-study
#16
Catherine H Stewart, Philip Berry, Dunja Przulj, Charlene Treanor
BACKGROUND: Links between participating in unhealthy behaviours, e.g. smoking, and an increased risk of developing some cancers are well established. Unemployed adults are more likely to participate in cancer-related health behaviours than their employed counterparts. However, evidence of whether this is true in young adults not in education, employment or training (NEET) compared to their 'non-NEET' peers is either limited or inconclusive. Using cross-sectional health data from across the UK, this study aims to investigate whether participation in cancer-related health behaviours varies by NEET status...
March 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28205535/phylogenetic-analysis-of-eukaryotic-neet-proteins-uncovers-a-link-between-a-key-gene-duplication-event-and-the-evolution-of-vertebrates
#17
Madhuri A Inupakutika, Soham Sengupta, Rachel Nechushtai, Patricia A Jennings, Jose' N Onuchic, Rajeev K Azad, Pamela Padilla, Ron Mittler
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the "NEET" motif. They are involved in the regulation of iron and reactive oxygen metabolism, and have been associated with the progression of diabetes, cancer, aging and neurodegenerative diseases. Despite their important biological functions, the evolution and diversification of eukaryotic NEET proteins are largely unknown. Here we used the three members of the human NEET protein family (CISD1, mitoNEET; CISD2, NAF-1 or Miner 1; and CISD3, Miner2) as our guides to conduct a phylogenetic analysis of eukaryotic NEET proteins and their evolution...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195537/-exit-exams-for-medical-graduates-a-guarantee-of-quality
#18
Ranjit Kumar Dehury, Janmejaya Samal
Despite a great deal of opposition from many segments of the medical community, the Medical Council of India (MCI) has proposed to the Ministry of Health and Family Welfare, Government of India that a pan-India exit examination be introduced for graduating MBBS doctors. Whether the proposal should be put forward was considered twice, once in 2010 and again in 2013, and finally the plan was ready to be taken forward seriously in 2015. The proposal has elicited appreciation and criticism from different segments of the medical community...
July 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28175944/erratum-to-a-prospective-cohort-study-of-depression-course-functional-disability-and-neet-status-in-help-seeking-young-adults
#19
Bridianne O'Dea, Rico S C Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykletun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
No abstract text is available yet for this article.
April 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28122584/are-we-failing-young-people-not-in-employment-education-or-training-neets-a-systematic-review-and-meta-analysis-of-re-engagement-interventions
#20
REVIEW
Lauren Mawn, Emily J Oliver, Nasima Akhter, Clare L Bambra, Carole Torgerson, Chris Bridle, Helen J Stain
BACKGROUND: Youth comprise 40% of the world's unemployed, a status associated with adverse wellbeing and social, health, and economic costs. This systematic review and meta-analysis review synthesises the literature on the effectiveness of interventions targeting young people not in employment, education, or training (NEET). METHODS: Randomised and quasi-randomised trials with a concurrent or counterfactual control group and baseline equivalence are included. Cochrane collaboration tools are used to assess quality, and a narrative synthesis was undertaken...
January 25, 2017: Systematic Reviews
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