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https://www.readbyqxmd.com/read/30444044/discourse-macrolinguistic-impairment-as-a-marker-of-linguistic-and-extralinguistic-functions-decline-in-early-alzheimer-s-disease
#1
Aurélie Pistono, M Jucla, C Bézy, B Lemesle, J Le Men, J Pariente
BACKGROUND: Alzheimer's disease is characterized by macrolinguistic changes. This decline is often analyzed with quantitative scales. AIMS: To analyze discourse production in early Alzheimer's disease (AD) and to identify qualitative markers of macrolinguistic decline. METHODS & PROCEDURES: We analyzed macrolinguistic features of a clinical narrative task along with patients' cognitive changes. To do so, 17 early AD participants and 17 healthy controls were recruited and given a full neuropsychological and language assessment...
November 15, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/30443455/the-neurocognitive-effects-of-ghrelin-induced-signaling-on-the-hippocampus-a-promising-approach-to-alzheimer-s-disease
#2
REVIEW
Robert S Seminara, Charan Jeet, Sharmi Biswas, Bushra Kanwal, Waleed Iftikhar, Md Sakibuzzaman, Ian H Rutkofsky
The communication between the gastrointestinal tract and the central nervous system (CNS) allows for certain peptide hormones to influence neurocognitive function. Ghrelin, also known as the 'hunger hormone,' has the unique ability to enter the CNS and interact with the growth hormone secretagogue receptor (GHS-R) within the hippocampus. Upon interaction with ghrelin, a conformational change in the receptor causes an increase in transcription factors to foster a wide array of physiologic changes in response to caloric deprivation...
September 11, 2018: Curēus
https://www.readbyqxmd.com/read/30441866/gut-microbiota-and-their-neuroinflammatory-implications-in-alzheimer-s-disease
#3
REVIEW
Vo Van Giau, Si Ying Wu, Angelo Jamerlan, Seong Soo A An, Sang Yun Kim, John Hulme
The bidirectional communication between the central nervous system (CNS) and the gut microbiota plays a pivotal role in human health. Increasing numbers of studies suggest that the gut microbiota can influence the brain and behavior of patients. Various metabolites secreted by the gut microbiota can affect the cognitive ability of patients diagnosed with neurodegenerative diseases. Nearly one in every ten Korean senior citizens suffers from Alzheimer's disease (AD), the most common form of dementia. This review highlights the impact of metabolites from the gut microbiota on communication pathways between the brain and gut, as well as the neuroinflammatory roles they may have in AD patients...
November 14, 2018: Nutrients
https://www.readbyqxmd.com/read/30430708/right-hippocampus-atrophy-is-independently-associated-with-alzheimer-s-disease-with-psychosis
#4
Kangyoon Lee, Young Min Lee, Je-Min Park, Byung-Dae Lee, Eunsoo Moon, Hee-Jeong Jeong, Soo Yeon Kim, Young-In Chung, Ji-Hoon Kim
AIM: The purpose of this study was to determine whether regionally distributed medial temporal cortex thickness (or hippocampal volume) and frontal lobe volume are independently associated with the onset of Alzheimer's disease (AD) with psychosis. METHODS: We identified 26 AD patients with psychosis (AD+P) and 48 AD patients without psychosis (AD-P) from the Memory Impairment Clinic at Pusan National University Hospital in South Korea. They were matched for age, gender, duration of AD, and Clinical Dementia Rating sum of box score...
November 14, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/30408611/use-it-or-lose-it-to-age-a-review-of-bone-and-muscle-communication
#5
Lynda Bonewald
Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. These two new concepts logically led to the third concept: that muscle and bone communicate via soluble factors...
November 5, 2018: Bone
https://www.readbyqxmd.com/read/30406006/the-global-burden-of-multiple-chronic-conditions-a-narrative-review
#6
REVIEW
Cother Hajat, Emma Stein
Globally, approximately one in three of all adults suffer from multiple chronic conditions (MCCs). This review provides a comprehensive overview of the resulting epidemiological, economic and patient burden. There is no agreed taxonomy for MCCs, with several terms used interchangeably and no agreed definition, resulting in up to three-fold variation in prevalence rates: from 16% to 58% in UK studies, 26% in US studies and 9.4% in Urban South Asians. Certain conditions cluster together more frequently than expected, with associations of up to three-fold, e...
December 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/30402773/carbenoxolone-reverses-the-amyloid-beta-1-42-oligomer-induced-oxidative-damage-and-anxiety-related-behavior-in-rats
#7
Sheetal Sharma, Neha Sharma, Avneet Saini, Bimla Nehru
The characteristic feature of Alzheimer's disease (AD) is the deposition of amyloid beta inside the brain mainly consisting of Aβ 40 and 42 aggregates. Soluble aggregates of Aβ 42 are reported to be more toxic and exert their neurotoxicity by the induction of oxidative damage and cognitive deficits such as anxiety-like behavior. These alterations emerge due to the induction of gap junction communication through increased activity and expression of connexins such as connexin43 (Cx43) leading to the release of small neurotoxic molecules...
November 7, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/30402203/connection-between-systemic-inflammation-and-neuroinflammation-underlies-neuroprotective-mechanism-of-several-phytochemicals-in-neurodegenerative-diseases
#8
REVIEW
Jintang Wang, Yuetao Song, Zheng Chen, Sean X Leng
Oxidative damage, mitochondrial dysfunction, and neuroinflammation are strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD), and a substantial portion of elderly population at risk of these diseases requires nutritional intervention to benefit health due to lack of clinically relevant drugs. To this end, anti-inflammatory mechanisms of several phytochemicals such as curcumin, resveratrol, propolis, polyunsaturated fatty acids (PUFAs), and ginsenosides have been extensively studied...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30386101/extracellular-vesicles-in-liver-disease-and-beyond
#9
EDITORIAL
Laura Morán, Francisco Javier Cubero
Extracellular vesicles (EVs) are membrane-derived vesicles which can be released by different cell types, including hepatocytes, hepatic stellate cells and immune cells in normal and pathological conditions. EVs carry lipids, proteins, coding and non-coding RNAs and mitochondrial DNA causing modifications on the recipient cells. These vesicles are considered potential biomarkers and therapeutic agents for human diagnostic and prognostic due to their function as intercellular mediators of cell-cell communication within the liver and between other organs...
October 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30373456/contributions-of-patient-and-citizen-researchers-to-am-i-the-right-way-up-study-of-balance-in-posterior-cortical-atrophy-and-typical-alzheimer-s-disease
#10
Sebastian J Crutch, Keir Xx Yong, Amy Peters, Dilek Ocal, Diego Kaski, Aida Suarez Gonzalez, Natalie Ryan, Simon Ball, Charlie R Harrison, Charlie Murphy, Pam Hulme, Isabel Phillips, Gaynor Hulme, Andrew Brown, Lu Brown, Peter Riley, Lynn Ramsey, Anthony Woods, Brian Day
The current report describes the journey from the sharing of a single, extraordinary experience during a support group conversation to the development of a novel scientific investigation of balance problems in a rarer form of dementia. The story centres around the involvement of people living with or caring for someone with posterior cortical atrophy (often referred to as the visual variant of Alzheimer's disease) in highlighting hitherto under-appreciated consequences of their condition upon their ability to know 'Am I the right way up?'...
November 2018: Dementia
https://www.readbyqxmd.com/read/30372021/classics-in-chemical-neuroscience-donepezil
#11
James T Brewster, Simone Dell'Acqua, Danny Q Thach, Jonathan L Sessler
The discovery of acetylcholine and acetylcholinesterase provided the first insight into the intricacies of chemical signal transduction and neuronal communication. Further elucidation of the underlying mechanisms led to an attendant leveraging of this knowledge via the synthesis of new therapeutics designed to control aberrant biochemical processes. The central role of the cholinergic system within human memory and learning, as well as its implication in Alzheimer's disease, has made it a point of focus within the neuropharmacology and medicinal chemistry communities...
November 8, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30367946/role-of-the-cd200-cd200r-axis-during-homeostasis-and-neuroinflammation
#12
REVIEW
Gemma Manich, Mireia Recasens, Tony Valente, Beatriz Almolda, Berta González, Bernardo Castellano
Microglia are considered to be the resident macrophages of the CNS and main effector of immune brain function. Due to their essential role in the regulation of neuroinflammatory response, microglia constitute an important target for neurological diseases, such as multiple sclerosis, Alzheimer's or Parkinson's disease. The communication between neurons and microglia contributes to a proper maintenance of homeostasis in the CNS. Research developed in the last decade has demonstrated that this interaction is mediated by "Off-signals" - molecules exerting immune inhibition - and "On signals" - molecules triggering immune activation...
October 24, 2018: Neuroscience
https://www.readbyqxmd.com/read/30334942/a-cluster-randomized-controlled-trial-to-test-the-feasibility-and-preliminary-effectiveness-of-a-family-dementia-caregiver-intervention-in-vietnam-the-reach-vn-study-protocol
#13
RANDOMIZED CONTROLLED TRIAL
Tuan Anh Nguyen, Huong Nguyen, Thang Pham, Trong Hung Nguyen, Ladson Hinton
BACKGROUND: Resources for Enhancing All Caregivers Health in the Department of Veterans Affairs (REACH VA) is an evidence-based intervention supporting family dementia caregivers that has been shown to improve caregiver outcomes for culturally diverse populations in the United States. However, this model has not been tested in low- and middle-income countries (LMICs) including Vietnam, where community-based psychosocial interventions are urgently needed. The objectives of this study are to assess the feasibility and preliminary effectiveness of a culturally adapted version of the Resources for Enhancing All Caregivers Health in Vietnam (REACH VN)...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30325875/a-feasibility-study-of-a-multifaceted-walking-intervention-to-maintain-the-functional-mobility-activities-of-daily-living-and-quality-of-life-of-nursing-home-residents-with-dementia
#14
Charlene H Chu, Martine Puts, Dina Brooks, Monica Parry, Katherine S McGilton
PURPOSE: The aim of the study was to evaluate the feasibility, acceptability, and efficacy of a multifaceted walking intervention (MWI) aimed to maintain the functional mobility, activities of daily living function, and quality of life of long-term care home residents with dementia. DESIGN/METHODS: A quasiexperimental time-series design was used. The 4-month intervention provided one-on-one walking 2-4 days a week, guided by an individualized communication care plan and interviews with collaterals and staff...
October 12, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/30325721/communication-predictors-of-patient-and-companion-satisfaction-with-alzheimer-s-genetic-risk-disclosure
#15
Yue Guan, Debra L Roter, Lori H Erby, Jennifer L Wolff, Laura N Gitlin, J Scott Roberts, Robert C Green, Kurt D Christensen
The objective of this study was to identify how features of Alzheimer's disease (AD) genetic risk disclosure communication relate to patient and visit companion satisfaction. We conducted secondary analyses of 79 session recordings from the fourth REVEAL Study, a randomized-controlled trial of AD genetic risk disclosure among patients with mild cognitive impairment. Patient and companion satisfaction were ascertained from postdisclosure surveys. The Roter Interaction Analysis System (RIAS) was used to code triadic communication between the counselor, patient, and companion...
2018: Journal of Health Communication
https://www.readbyqxmd.com/read/30319362/bidirectional-microglia-neuron-communication-in-health-and-disease
#16
REVIEW
Zsuzsanna Szepesi, Oscar Manouchehrian, Sara Bachiller, Tomas Deierborg
Microglia are ramified cells that exhibit highly motile processes, which continuously survey the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia have long been recognized as a crucial player in generating and maintaining inflammatory responses in the CNS, now it has become clear, that their function are much more diverse, particularly in the healthy brain. The innate immune response and phagocytosis represent only a little segment of microglia functional repertoire that also includes maintenance of biochemical homeostasis, neuronal circuit maturation during development and experience-dependent remodeling of neuronal circuits in the adult brain...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30305443/atrial-fibrillation-antithrombotic-treatment-and-cognitive-aging-a-population-based-study
#17
Mozhu Ding, Laura Fratiglioni, Kristina Johnell, Giola Santoni, Johan Fastbom, Petter Ljungman, Alessandra Marengoni, Chengxuan Qiu
OBJECTIVE: To examine the association of atrial fibrillation (AF) with cognitive decline and dementia in old age, and to explore the cognitive benefit of antithrombotic treatment in patients with AF. METHODS: This population-based cohort study included 2,685 dementia-free participants from the Swedish National Study on Aging and Care in Kungsholmen, who were regularly examined from 2001-2004 to 2010-2013. AF was ascertained from clinical examination, ECG, and patient registry...
October 10, 2018: Neurology
https://www.readbyqxmd.com/read/30298186/supplement-11th-conference-clinical-trials-alzheimer-s-disease-october-24-27-2018-barcelona-spain-symposia-oral-communications-late-breaking-news
#18
(no author information available yet)
No abstract text is available yet for this article.
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/30287345/coconut-oil-decreases-expression-of-amyloid-precursor-protein-app-and-secretion-of-amyloid-peptides-throughinhibitionof-adp-ribosylation-factor-1-arf1
#19
Ananya Bansal, Megan Kirschner, Li Zu, Dongming Cai, Lumin Zhang
Alzheimer's disease (AD), affecting 5.3 million people in the U.S., impairs portions of the brain controlling memories. In humans, mutations in the amyloid precursor protein (APP) gene has been implicated in increased plaque formation, which can block the communication between nerve cells, decrease dendritic formation and increase cell death, and promote neuroinflammation. As coconut oil has been suggested to alleviate the symptoms in AD patients, we examined the impact of coconut oil on APP expression and secretion of amyloid peptides in N2a cells expressing the human APP gene (N2a/APP695)...
October 1, 2018: Brain Research
https://www.readbyqxmd.com/read/30284480/photojournalism-based-intervention-reduces-caregiver-burden-and-depression-in-alzheimer-s-disease-family-caregivers
#20
Whitney Wharton, Fayron Epps, Mariya Kovaleva, Lindsey Bridwell, Rachanice Candy Tate, Cornelya D Dorbin, Kenneth Hepburn
PURPOSE: Art interventions have demonstrated holistic benefits for persons living with dementia and their caregivers. In this article, we describe the results of a pilot photojournalism program for 10 unpaid caregivers of persons living with dementia, with respect to caregivers' experience in the program and their psychological well-being. DESIGN: Caregivers participated in four sessions led by a professional photojournalist who taught principles of photography...
October 4, 2018: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
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