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https://www.readbyqxmd.com/read/29051137/alzheimer-s-disease-in-social-media-content-analysis-of-youtube-videos
#1
Weizhou Tang, Kate Olscamp, Seul Ki Choi, Daniela B Friedman
BACKGROUND: Approximately 5.5 million Americans are living with Alzheimer's disease (AD) in 2017. YouTube is a popular platform for disseminating health information; however, little is known about messages specifically regarding AD that are being communicated through YouTube. OBJECTIVE: This study aims to examine video characteristics, content, speaker characteristics, and mobilizing information (cues to action) of YouTube videos focused on AD. METHODS: Videos uploaded to YouTube from 2013 to 2015 were searched with the term "Alzheimer's disease" on April 30th, 2016...
October 19, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29028937/abnormal-structural-brain-connectome-in-individuals-with-preclinical-alzheimer-s-disease
#2
Joana B Pereira, Danielle van Westen, Erik Stomrud, Tor Olof Strandberg, Giovanni Volpe, Eric Westman, Oskar Hansson
Alzheimer's disease has a long preclinical phase during which amyloid pathology and neurodegeneration accumulate in the brain without producing overt cognitive deficits. It is currently unclear whether these early disease stages are associated with a progressive disruption in the communication between brain regions that subsequently leads to cognitive decline and dementia. In this study we assessed the organization of structural networks in cognitively normal (CN) individuals harboring amyloid pathology (A+N-), neurodegeneration (A-N+), or both (A+N+) from the prospective and longitudinal Swedish BioFINDER study...
October 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29022655/anosognosia-is-an-independent-predictor-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-is-associated-with-reduced-brain-metabolism
#3
Philip Gerretsen, Jun Ku Chung, Parita Shah, Eric Plitman, Yusuke Iwata, Fernando Caravaggio, Shinichiro Nakajima, Bruce G Pollock, Ariel Graff-Guerrero
OBJECTIVE: Anosognosia, or impaired illness awareness, is a common feature of Alzheimer's disease (AD) and less so of mild cognitive impairment (MCI). Importantly, anosognosia negatively influences clinical outcomes for patients and their caregivers and may predict the conversion from MCI to AD. This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction...
October 10, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29017893/chronic-inflammation-inflammaging-in-the-ageing-cochlea-a-novel-target-for-future-presbycusis-therapy
#4
Nathan Watson, Bo Ding, Xiaoxia Zhu, Robert D Frisina
Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-related pathologies and natural processes in aging tissue, including the nervous system. Over the past two decades, much effort has been done to understand the mechanisms of inflammaging in disease models such as type II diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and others. However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top three chronic medical conditions of our aged population; little research has been conducted on the potential role of inflammation in age-related hearing loss (ARHL)...
October 7, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29016849/differential-protective-effects-of-connective-tissue-growth-factor-against-a%C3%AE-neurotoxicity-on-neurons-and-glia
#5
Cheng-Ning Yang, Min-Fang Wu, Chung-Chih Liu, Wei-Hung Jung, Yu-Chin Chang, Wang-Pao Lee, Young-Ji Shiao, Chia-Lin Wu, Horng-Huei Liou, Sze-Kwan Lin, Chih-Chiang Chan
Impaired clearance of amyloid-β peptide (Aβ) leads to abnormal extracellular accumulation of this neurotoxic protein that drives neurodegeneration in sporadic Alzheimer's disease (AD). Connective tissue growth factor (CTGF/CCN2) expression is elevated in plaque-surrounding astrocytes in AD patients. However, the role of CTGF in AD pathogenesis remains unclear. Here we characterized the neuroprotective activity of CTGF. We found that CTGF facilitated Aβ uptake and subsequent degradation within primary glia and neuroblastoma cells...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28993311/central-and-peripheral-circadian-clocks-and-their-role-in-alzheimer-s-disease
#6
REVIEW
Ruchi Chauhan, Ko-Fan Chen, Brianne A Kent, Damian C Crowther
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology...
October 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28990871/cultural-adaptation-of-a-dyadic-intervention-for-korean-couples-coping-with-alzheimer-s-disease
#7
Minyoung Kwak, Jung-Hwa Ha, So-Yeon Hwang, Berit Ingersoll-Dayton, Beth Spencer
OBJECTIVES: The Couples Life Story Approach (CLSA) was recently reveloped in the U.S. for older couples dealing with dementia to improve their quality of life. The purpose of this article is to describe how the CLSA was adapted to be culturally appropriate for older Korean couples and to discuss cultural htemes that emerged during the implementation process. METHODS: The intervention was adapted using the Cultural Adaptation Process Model. The revised materials were implemented on 56 Korean couples...
August 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28986925/cerebral-blood-flow-in-normal-aging-adults-cardiovascular-determinants-clinical-implications-and-aerobic-fitness
#8
REVIEW
Takashi Tarumi, Rong Zhang
Senescence is a leading cause of mortality, disability, and non-communicable chronic diseases in older adults. Mounting evidence indicates that the presence of cardiovascular disease and risk factors elevates the incidence of both vascular cognitive impairment and Alzheimer's disease (AD). Age-related declines in cardiovascular function may impair cerebral blood flow (CBF) regulation, leading to the disruption of neuronal micro-environmental homeostasis. The brain is the most metabolically active organ with limited intracellular energy storage and critically depends on CBF to sustain neuronal metabolism...
October 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28982320/astroglial-connexins-as-a-therapeutic-target-for-alzheimer-s-disease
#9
Chenju Yi, Annette Koulakoff, Christian Giaume
BACKGROUND: In Alzheimer's disease (AD), modification of astrocytic properties is a well-known and documented fact, but their involvement in pathophysiology has only been examined in recent years. One distinct hallmark of AD is reactive gliosis which are represented in microglial and astrocytic phenotype changes. This reactive gliosis has been associated with changes in the expression and function of connexins. Connexins are proteins that can form gap junction channels and hemichannels, and in a disease context, have shown increased expression in astrocytes that contact amyloid plaques in vivo...
October 4, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28974110/acetylcholinesterase-inhibitors-beneficial-effects-on-comorbidities-in-patients-with-alzheimer-s-disease
#10
Vinod Kaushik, Sarah Toombs Smith, Emmanuel Mikobi, Mukaila A Raji
Elderly patients with Alzheimer's disease (AD) and other dementias are at high risk of polypharmacy and excessive polypharmacy for common coexisting medical conditions. Polypharmacy increases the risk of drug-drug and drug-disease interactions in these patients who may not be able to communicate early symptoms of adverse drug events. Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). They are also used off-label for other causes of dementia such as Lewy body and vascular dementia...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28969160/anti-alzheimer-properties-of-probiotic-lactobacillus-plantarum-mtcc-1325-in-alzheimer-s-disease-induced-albino-rats
#11
Mallikarjuna Nimgampalle, Yellamma Kuna
INTRODUCTION: Alzheimer's disease is a type of dementia, and till now there is no suitable drug available for the complete cure of this disease. Now-a-days Probiotics, Lactobacillus strains play a therapeutic role in cognitive disorders through Gut-Brain Axis communication. AIM: The present study was aimed to evaluate the anti-Alzheimer properties of Lactobacillus plantarum MTCC1325 against D-Galactose-induced Alzheimer's disease in albino rats. MATERIALS AND METHODS: Healthy rats (48) of wistar strain were divided into four groups viz...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28968238/sex-differences-in-the-psychophysical-response-to-contact-heat-in-moderate-cognitive-impairment-alzheimer-s-disease-a-cross-sectional-brief-report
#12
Ronald L Cowan, Paul A Beach, Sebastian W Atalla, Mary S Dietrich, Stephen P Bruehl, Jie Deng, Jinjiao Wang, Paul A Newhouse, John C Gore, Todd B Monroe
BACKGROUND: People with Alzheimer's disease (AD) report pain less frequently and receive less pain medication than people without AD. Recent studies have begun to elucidate how pain may be altered in those with AD. However, potential sex differences in pain responsiveness have never been explored in these patients. It is unclear whether sex differences found in prior studies of healthy young and older individuals extend to people with AD. OBJECTIVE: The purpose of this study was to examine sex differences in the psychophysical response to experimental thermal pain in people with AD...
September 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28956332/from-age-related-cognitive-decline-to-alzheimer-s-disease-a-translational-overview-of-the-potential-role-for-phosphodiesterases
#13
Pim R A Heckman, Arjan Blokland, Jos Prickaerts
Phosphodiesterase inhibitors (PDE-Is) are pharmacological compounds enhancing cAMP and/or cGMP signaling. Both these substrates affect neural communication by influencing presynaptic neurotransmitter release and postsynaptic intracellular pathways after neurotransmitter binding to its receptor. Both cAMP and cGMP play an important role in a variety of cellular functions including neuroplasticity and neuroprotection. This chapter provides a translational overview of the effects of different classes of PDE-Is on cognition enhancement in age-related cognitive decline and Alzheimer's disease (AD)...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28931491/global-regional-and-national-burden-of-neurological-disorders-during-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#14
(no author information available yet)
BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28931443/conversational-assessment-of-cognitive-dysfunction-among-residents-living-in-long-term-care-facilities
#15
Hikaru Oba, Shinichi Sato, Hiroaki Kazui, Yoshiko Nitta, Tatsuya Nashitani, Akio Kamiyama
BACKGROUND: There are some existing barriers posed by neuropsychological tests that interfere with the assessment of cognitive functioning by staff who work in long-term care facilities. The purpose of this study was to investigate the feasibility of assessing cognitive function through conversation. METHODS: A total of 100 care staff was randomly selected as participants. Each staff member evaluated cognitive function in one to three residents using the Conversational Assessment of Neurocognitive Dysfunction (CANDy), which is a screening test for dementia using conversation...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28919117/global-regional-and-national-incidence-prevalence-and-years-lived-with-disability-for-328-diseases-and-injuries-for-195-countries-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#16
(no author information available yet)
BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28918118/case-report-aquatic-therapy-and-end-stage-dementia
#17
Bruce E Becker, Stacy Lynch
A 54-year old female, retired due to progressive cognitive decline, was diagnosed with early-onset Alzheimer's dementia. Conventional medication therapy for dementia had proven futile. Initial evaluation revealed a non-verbal female seated in a wheelchair, dependent on 2-person assist for all transfers and activities of daily living (ADLs.) She had been either non-responsive or actively resistive for both ADLs and transfers in the 6 months prior to assessment. Following a total of 17 one hour therapy sessions over 19 weeks in a warm water therapy pool, she achieved ability to tread water for 15 minutes, transfers improved to moderate to-maximum assist from seated, ambulation improved to 1000' with minimum-to-moderate assist of 2 persons...
September 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28914212/-from-being-a-child-to-being-ill-changes-in-thinking-about-alzheimer-s-disease
#18
K Neuvel
In 1984 the public consciousness about Alzheimer's disease radically changed. Suddenly, especially in the media, a tremendous interest in the phenomenon arose. In the years before, there was hardly any public knowledge about 'Alzheimer's disease'. Mental deterioration was seen as a natural and inevitable part of a human being's course of life. Starting in 1984 however, this deterioration was seen as the most dreaded disease that could struck a person. The disease seemed to rob a person from its most essential abilities: the ability to think, to communicate and to be an individual...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28912682/extracellular-vesicles-in-brain-tumors-and-neurodegenerative-diseases
#19
REVIEW
Federica Ciregia, Andrea Urbani, Giuseppe Palmisano
Extracellular vesicles (EVs) can be classified into apoptotic bodies, microvesicles (MVs), and exosomes, based on their origin or size. Exosomes are the smallest and best characterized vesicles which derived from the endosomal system. These vesicles are released from many different cell types including neuronal cells and their functions in the nervous system are investigated. They have been proposed as novel means for intercellular communication, which takes part not only to the normal neuronal physiology but also to the transmission of pathogenic proteins...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28881854/microbiota-gut-brain-axis-and-the-central-nervous-system
#20
REVIEW
Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin, Wei Yi
The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis...
August 8, 2017: Oncotarget
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