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Dafna Willner, Valeria Spennati, Shelly Stohl, Giulia Tosti, Simone Aloisio, Federico Bilotta
Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraoperative and postoperative blood loss. The aim of this systematic review is to report clinical evidence on the relationship between intraoperative blood loss (primary outcome) and on transfusion requirements and postoperative complications (secondary outcomes) in patients undergoing spine surgery...
October 3, 2016: Anesthesia and Analgesia
Kate E Oberlin, Erin X Wei, Jeong Hee Cho-Vega, Antonella Tosti
No abstract text is available yet for this article.
September 28, 2016: JAMA Dermatology
Grazia Tosone, Silvia Mascolo, Roberto Bruni, Stefania Taffon, Michele Equestre, Maria Elena Tosti, Anna Rita Ciccaglione, Fiorella Martucci, Alfonso Liberti, Maria Donata Iannece, Raffaele Orlando
Hepatitis A virus is a widely occurring disease, with different prevalence rates between countries in the North and West and those in the South and East. In Italy endemicity is low/medium, but not homogeneously distributed: in the northern/central regions a large hepatitis A outbreak due to genotype IA, related to the consumption of contaminated mixed frozen berries, occurred between 2013 and 2014, whereas in southern Italian regions recurrent outbreaks of hepatitis A, due to the IB genotype, still result from consumption of raw seafood...
September 1, 2016: Le Infezioni in Medicina
Alina Goldenberg, Nico Mousdicas, Nanette Silverberg, Douglas Powell, Janice L Pelletier, Jonathan I Silverberg, Jonathan Zippin, Luz Fonacier, Antonella Tosti, Leslie Lawley, Mary Wu Chang, Andrew Scheman, Gary Kleiner, Judith Williams, Kalman Watsky, Cory A Dunnick, Rachel Frederickson, Catalina Matiz, Keri Chaney, Tracy S Estes, Nina Botto, Michelle Draper, Leon Kircik, Aida Lugo-Somolinos, Brian Machler, Sharon E Jacob
BACKGROUND: Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed. OBJECTIVE: The aim was to quantify patch test results from providers evaluating US children. METHODS: The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016)...
September 2016: Dermatitis
Isabella Doche, Colombina Vincenzi, Antonella Tosti
No abstract text is available yet for this article.
October 2016: Journal of the American Academy of Dermatology
S S Martins, L S Abraham, I Doche, B M Piraccini, C Vincenzi, A Tosti
Acute hair matting (AHM) is a rare condition presenting as a compact mass with irregular twists and severely entangled hairs abruptly formed in the scalp. First reported as "plica neuropathica" by Le Page in 1884, the condition was thought to be due to hysteria(1) . However, the term "plica polonica" was also very prevalent in Poland in the 19(th) century, when the polish custom of wearing tight fur caps and not washing the hair contributed to a filthy and malodorous compact mass, usually associated with lice infection and inflammation in the scalp (2) ...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Patrizia Carrarelli, Alice Luddi, Lucia Funghi, Felice Arcuri, Frederic Batteux, Cynthia Dela Cruz, Claudia Tosti, Fernando M Reis, Charles Chapron, Felice Petraglia
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) are the most severe forms of endometriosis, but different pathogenetic mechanisms and clinical symptoms distinguish these two forms. Corticotrophin-releasing hormone (CRH) and urocortin (Ucn) are endometrial neuropeptides involved in tissue differentiation and inflammation. The expression of CRH, Ucn, Ucn2, CRH-receptors (type-1 and type-2) and inflammatory enzymes phospholipase-A2 group IIA (PLA2G2A) and cycloxygenase-2 (COX2) were evaluated in OMA (n = 22) and DIE (n = 26)...
October 2016: Reproductive Biomedicine Online
Yanna Kelly, Aline Blanco, Antonella Tosti
Androgenetic alopecia (AGA) is characterized by a non-scarring progressive miniaturization of the hair follicle in predisposed men and women with a pattern distribution. Although AGA is a very prevalent condition, approved therapeutic options are limited. This article discusses the current treatment alternatives including their efficacy, safety profile, and quality of evidence. Finasteride and minoxidil for male androgenetic alopecia and minoxidil for female androgenetic alopecia still are the therapeutic options with the highest level evidence...
September 2016: Drugs
Jasper Most, Valeria Tosti, Leanne M Redman, Luigi Fontana
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials indicate that CR in humans results in some of the same metabolic and molecular adaptations that have been shown to improve health and retard the accumulation of molecular damage in animal models of longevity. In particular, moderate CR in humans ameliorates multiple metabolic and hormonal factors that are implicated in the pathogenesis of type 2 diabetes, cardiovascular diseases, and cancer, the leading causes of morbidity, disability and mortality...
August 17, 2016: Ageing Research Reviews
Claudia Tosti, Antonella Biscione, Giuseppe Morgante, Giuseppe Bifulco, Stefano Luisi, Felice Petraglia
Endometriotic lesions are associated with hormonal imbalance, including increased estrogen synthesis, metabolism and progesterone resistance. These hormonal changes cause increased proliferation, inflammation, pain and infertility. Hormonal imbalances are targets for treatment. Therapeutic strategies and innovations of hormonal drugs for endometriosis are increasing. Acting on estrogen receptors are hormonal drugs decreasing systemic and local estrogen synthesis (GnRH analogs, GnRH antagonists, Aromatase inhibitors) or estrogen activity (selective estrogen receptor modulators)...
May 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Marianna Colamaio, Nadia Tosti, Francesca Puca, Alessia Mari, Rosaria Gattordo, Yalçın Kuzay, Antonella Federico, Anna Pepe, Daniela Sarnataro, Elvira Ragozzino, Maddalena Raia, Hidenari Hirata, Marica Gemei, Koshi Mimori, Luigi Del Vecchio, Sabrina Battista, Alfredo Fusco
OBJECTIVE: Glioblastoma multiforme (GBM) develops from a small subpopulation of stem-like cells, which are endowed with the ability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. These cells are resistant to conventional chemo- and radiotherapy and are hence also responsible for tumor recurrence. HMGA1 overexpression has been shown to correlate with proliferation, invasion, and angiogenesis of GBMs and to affect self-renewal of cancer stem cells from colon cancer...
October 2016: Expert Opinion on Therapeutic Targets
Evan A Rieder, Antonella Tosti
Onychotillomania is an uncommon and likely underreported condition in which patients repetitively manipulate the different constituents of the nail unit. Onychotillomania is characterized by a range of nonspecific findings, including bizarre morphology of the nail plate and damage to the nail bed and periungual skin. Histopathological changes are also nonspecific, but may be viewed as analogous to lichen simplex chronicus and prurigo nodularis of the skin. Clinical history is essential to making this diagnosis, as effective treatment modalities may focus on behavioral therapies and psychiatric medications...
July 26, 2016: Journal of the American Academy of Dermatology
Evan A Rieder, Antonella Tosti
The nail carries a significant cosmetic impact and plays an integral role in the multi-billion dollar salon industry. This review focuses on nail disorders that are induced by nail cosmetics via procedures, equipment, or materials that are intended to beautify or adorn the nail. The authors give specific attention to clinical presentations that are common, novel, and underreported, but may be misdiagnosed easily by the competent dermatologist. They also provide an update on the controversies surrounding contemporary nail cosmetic procedures, such as acrylic and gel manicures...
April 2016: Journal of Clinical and Aesthetic Dermatology
Patrizia Carrarelli, Chih-Feng Yen, Lucia Funghi, Felice Arcuri, Claudia Tosti, Giuseppe Bifulco, Alice Luddi, Chyi-Long Lee, Felice Petraglia
OBJECTIVE: Adenomyosis is a uterine disorder characterized by dysmenorrhea, dyspareunia, abnormal uterine bleeding, and infertility. Pathogenesis indicates that endometrial cells invade and proliferate within myometrium, and inflammatory mediators participate to the intense painful symptoms. The aim of the present study was to investigate the messenger RNA (mRNA) and protein expression of inflammatory (interleukin 1β [IL-1β], corticotropin-releasing hormone [CRH], urocortin [Ucn]) and neurogenic (nerve growth factors [NGFs], synaptophysin [SYN], microtubule-associated protein 2 [MAP2]) factors in adenomyotic nodules...
July 20, 2016: Reproductive Sciences
Giordana Zanna, Paola Roccabianca, Eric Zini, Sara Legnani, Fabia Scarampella, Silvana Arrighi, Antonella Tosti
BACKGROUND: Dermoscopic studies evaluating noninflammatory, nonpruritic progressive alopecia attributable to pattern alopecia are currently unavailable. HYPOTHESIS/OBJECTIVES: To evaluate the dermoscopic features observed in healthy skin of short coated dogs and compare these findings with those observed in dogs affected by pattern alopecia diagnosed by clinical and dermatopathological examination. ANIMALS: Thirty male and female, healthy, breed matched, young adult, short coated dogs (controls) and 30 male and female, young adult, short coated dogs affected by pattern alopecia...
July 18, 2016: Veterinary Dermatology
Cornelia Adlhoch, Ana Avellon, Sally A Baylis, Anna R Ciccaglione, Elisabeth Couturier, Rita de Sousa, Jevgenia Epštein, Steen Ethelberg, Mirko Faber, Ágnes Fehér, Samreen Ijaz, Heidi Lange, Zdenka Manďáková, Kassiani Mellou, Antons Mozalevskis, Ruska Rimhanen-Finne, Valentina Rizzi, Bengü Said, Lena Sundqvist, Lelia Thornton, Maria E Tosti, Wilfrid van Pelt, Esther Aspinall, Dragoslav Domanovic, Ettore Severi, Johanna Takkinen, Harry R Dalton
BACKGROUND: Hepatitis E virus (HEV) is endemic in EU/EEA countries, but the understanding of the burden of the infection in humans is inconsistent as the disease is not under EU surveillance but subject to national policies. STUDY: Countries were asked to nominate experts and to complete a standardised questionnaire about the epidemiological situation and surveillance of HEV in their respective EU/EEA country. This study reviewed surveillance systems for human cases of HEV in EU/EEA countries and nominated experts assessed the epidemiology in particular examining the recent increase in the number of autochthonous cases...
September 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Arianna Trionfo, Joseph J Thoder, Rick Tosti
BACKGROUND: Traditional management of hand abscesses consists of withholding antibiotics prior to drainage to optimize bacterial culture growth and outcome. The purpose of this study was to determine the effect of preoperative empiric antibiotics on the rate of culture growth and rate of adverse events in patients with acute hand abscesses. METHODS: We performed a retrospective review of prospectively collected data on 88 consecutive hand abscesses that received empiric antibiotics prior to incision and drainage from 2012 to 2013 at an urban academic institution...
June 2016: Hand: Official Journal of the American Association for Hand Surgery
Saverio Caini, Sofia Cattaruzza, Benedetta Bendinelli, Giulio Tosti, Giovanna Masala, Patrizia Gnagnarella, Melania Assedi, Ignazio Stanganelli, Domenico Palli, Sara Gandini
PURPOSE: Laboratory studies suggested that caffeine and other nutrients contained in coffee and tea may protect against non-melanoma skin cancer (NMSC). However, epidemiological studies conducted so far have produced conflicting results. METHODS: We performed a literature review and meta-analysis of observational studies published until February 2016 that investigated the association between coffee and tea intake and NMSC risk. We calculated summary relative risk (SRR) and corresponding 95 % confidence intervals (95 % CI) by using random effects with maximum likelihood estimation...
July 7, 2016: European Journal of Nutrition
Penelope Kallis, Antonella Tosti
Nail dermoscopy is helpful in the differential diagnosis of nail disorders including onychomycosis and pigmented and nonpigmented nail tumors. We report two cases of onychomatricoma with concurrent onychomycosis of the same digit. In both cases, dermoscopy of the nail plate exhibited features of onychomatricoma, whereas dermoscopy of the distal free edge revealed features of onychomycosis. It is not uncommon for patients with onychomatricoma to develop coexisting onychomycosis, as channels created by the tumor render the nail plate susceptible to invasion by fungi...
May 2016: Skin Appendage Disorders
Luigi Fontana, Nicole E Cummings, Sebastian I Arriola Apelo, Joshua C Neuman, Ildiko Kasza, Brian A Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A Syed, Emma L Baar, Nicola Veronese, Sara E Cottrell, Rachel J Fenske, Beatrice Bertozzi, Harpreet K Brar, Terri Pietka, Arnold D Bullock, Robert S Figenshau, Gerald L Andriole, Matthew J Merrins, Caroline M Alexander, Michelle E Kimple, Dudley W Lamming
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways...
July 12, 2016: Cell Reports
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