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https://www.readbyqxmd.com/read/29276793/short-term-consumption-of-a-plant-protein-diet-does-not-improve-glucose-homeostasis-of-young-c57bl-6j-mice
#1
Dudley W Lamming, Emma L Baar, Sebastian I Arriola Apelo, Valeria Tosti, Luigi Fontana
Recently, it has become apparent that dietary macronutrient composition has a profound impact on metabolism, health and even lifespan. Work from many laboratories now suggest that dietary protein quality - the precise amino acid composition of the diet, as well as possibly the source of dietary protein - may also be critical in regulating the impact of diet on health. Perhaps in part due to the naturally low methionine content of plants, vegan diets are associated with a decreased risk of diabetes and improved insulin sensitivity, but this association is confounded by the lower overall protein intake of vegans...
December 7, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/29273101/treatment-of-alopecia-areata-with-simvastatin-ezetimibe
#2
REVIEW
Jessica Cervantes, Joaquin J Jimenez, Gina M DelCanto, Antonella Tosti
Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29244059/the-mediterranean-diet-metabolic-and-molecular-mechanisms
#3
Valeria Tosti, Beatrice Bertozzi, Luigi Fontana
Consuming a Mediterranean diet rich in minimally processed plant foods has been associated with a reduced risk of developing multiple chronic diseases and increased life expectancy. Data from several randomized clinic trials have demonstrated a beneficial effect in the primary and secondary prevention of cardiovascular disease, type 2 diabetes, atrial fibrillation and breast cancer. The exact mechanism by which an increased adherence to the traditional Mediterranean diet exerts its favorable effects is not known...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29214287/optical-coherence-tomography-features-of-dermatophytoma
#4
Sebastian H Verne, Lucy Chen, Vidhi Shah, Keyvan Nouri, Antonella Tosti
No abstract text is available yet for this article.
December 6, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29209689/could-a-vitamin-d-deficiency-cause-a-combined-long-term-fev1-and-bone-mineral-density-deterioration-in-female-asthmatics
#5
B Sposato, M Scalese, L Petruzzelli, E Baldini, N Nikiforakis, M Tosti Balducci
OBJECTIVES: We already know that asthma is associated to osteoporosis/osteopenia and characterized by an accelerated lung function decline. Our study aimed at assessing whether lung function decline and bone mineral density (BMD) deterioration in time were associated in a group of female long-standing asthmatics. We also tried to understand whether these two aspects were related to ICS treatment and vitamin D levels. METHODS: 35 female asthmatics were retrospectively analysed...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29194786/microneedling-for-the-treatment-of-hair-loss
#6
REVIEW
Raymond M Fertig, A Caresse Gamret, Jessica Cervantes, Antonella Tosti
Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization, and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet rich plasma, and topical steroids, and shown to stimulate hair follicle growth...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29177154/syphilitic-alopecia-case-reports-and-trichoscopic-findings
#7
Isabella Doche, Maria K Hordinsky, Neusa Y S Valente, Ricardo Romiti, Antonella Tosti
There has been a resurgence of syphilis in the last decade. Although alopecia is not a common manifestation of the disease, the "moth-eaten" pattern is considered patognomonic. However, diffuse hair loss, termed essential alopecia, sometimes can be the only sign of syphilis infection and mimic other conditions, such as alopecia areata and telogen effluvium. We describe three patients with syphilis in whom the pattern of alopecia was not typical. Although clinical, histopathological, and trichoscopic examinations may share some similar findings with other hair diseases, the inclusion of syphilis in the differential diagnosis of hair loss causes is fundamental to a correct screening and diagnosis...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29174331/constitutively-active-smad2-3-are-broad-scope-potentiators-of-transcription-factor-mediated-cellular-reprogramming
#8
Tyson Ruetz, Ulrich Pfisterer, Bruno Di Stefano, James Ashmore, Meryam Beniazza, Tian V Tian, Daniel F Kaemena, Luca Tosti, Wenfang Tan, Jonathan R Manning, Eleni Chantzoura, Daniella Rylander Ottosson, Samuel Collombet, Anna Johnsson, Erez Cohen, Kosuke Yusa, Sten Linnarsson, Thomas Graf, Malin Parmar, Keisuke Kaji
Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired cell types using this approach is often plagued by inefficiency, slow conversion, and an inability to produce mature functional cells. Here, we show that expression of constitutively active SMAD2/3 significantly improves the efficiency of induced pluripotent stem cell (iPSC) generation by the Yamanaka factors...
November 13, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29171081/in-vitro-determination-of-mexican-mestizo-hair-shaft-diameter-using-optical-coherence-tomography
#9
Maria Abril Martinez-Velasco, Marina Perper, Austin J Maddy, Jessica Cervantes, Ariel E Eber, Sebastian H Verne, Norma Elizabeth Vazquez-Herrera, Keyvan Nouri, Antonella Tosti
BACKGROUND: Mexican mestizo population has a pluriethnic mixture of Amerindian, European and African ancestry, predominant in most Latin American countries. Until now, there are no reports about hair characteristics in this population, necessary to define normal values, for hair diseases evaluation and comparison among other ethnic groups. METHODS: The VivoSight® swept-source multibeam optical coherence tomography system was used to evaluate hair diameter and shape in 30 females...
November 23, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/29169593/-damage-control-hand-surgery-evaluation-and-emergency-management-of-the-mangled-hand
#10
REVIEW
Rick Tosti, Kyle R Eberlin
Mangled hand injuries are defined as those with significant damage to multiple structures, which may be limb threatening. Historically these injuries resulted in amputation or death, but modern surgical and perioperative advances allow for complex reconstruction and the possibility of a sensate and functional limb. Evaluation begins with surveying for life-threatening injuries followed by a systematic approach to identify injured structures; management begins with preserving all parts, minimizing warm ischemia time, performing débridement, and planning an operative approach to optimize the chance of a functional limb...
February 2018: Hand Clinics
https://www.readbyqxmd.com/read/29128463/objective-outcome-measures-collecting-meaningful-data-on-alopecia-areata
#11
Elise A Olsen, Janet Roberts, Leonard Sperling, Antonella Tosti, Jerry Shapiro, Amy McMichael, Wilma Bergfeld, Valerie Callender, Paradi Mirmirani, Ken Washenik, David Whiting, George Cotsarelis, Maria Hordinsky
BACKGROUND: Although alopecia areata is a common disorder, it has no FDA approved treatment and evidence-based therapeutic data is lacking. OBJECTIVE: To develop guidelines for the diagnosis, evaluation, assessment, response criteria and endpoints for alopecia areata. METHODS: Literature review and expert opinion of a group of dermatologists specializing in hair disorders. RESULTS: Standardized methods of assessing and tracking hair loss and growth including new scoring techniques, response criteria and endpoints in alopecia areata are presented...
November 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29064882/crossfit-associated-allergic-contact-dermatitis
#12
Jennifer A Ledon, Antonella Tosti
No abstract text is available yet for this article.
November 2017: Dermatitis
https://www.readbyqxmd.com/read/29061368/dermoscopic-technique-for-the-evaluation-of-the-nail-unit
#13
Jorge Ocampo-Garza, Paula Jacomini Sobral, Joana Mendes Bretas, Daiane Matana, Antonella Tosti
No abstract text is available yet for this article.
October 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28968938/insights-into-the-cuo-nanoparticle-ecotoxicity-with-suitable-marine-model-species
#14
A Rotini, A Gallo, I Parlapiano, M T Berducci, R Boni, E Tosti, E Prato, C Maggi, A M Cicero, L Migliore, L Manfra
Metal oxide nanoparticles, among them copper oxide nanoparticles (CuO NPs), are widely used in different applications (e.g. batteries, gas sensors, superconductors, plastics and metallic coatings), increasing their potential release in the environment. In aquatic matrix, the behavior of CuO NPs may strongly change, depending on their surface charge and some physical-chemical characteristics of the medium (e.g. ionic strength, salinity, pH and natural organic matter content). Ecotoxicity of CuO NPs to aquatic organisms was mainly studied on freshwater species, few tests being performed on marine biota...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28960450/pterygium-inversum-unguis-secondary-to%C3%A2-gel-polish
#15
J Cervantes, M Sanchez, A E Eber, M Perper, A Tosti
BACKGROUND: Pterygium inversum unguis (PIU) is characterized by the abnormal adherence of the hyponychium to the ventral surface of the nail plate. It can be both unsightly and painful, resulting in morbidity for patients. Gel polish is a popular nail cosmetic that has been reported to cause several complications. PIU may be another adverse outcome. OBJECTIVE: To highlight a newly-recognized adverse effect of a popular beauty technique. METHODS: This retrospective and prospective case series reports 17 women who developed PIU after gel polish use...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28937587/%C3%A2%C2%B5-conotoxins-modulating-sodium-currents-in-pain-perception-and-transmission-a-therapeutic-potential
#16
REVIEW
Elisabetta Tosti, Raffaele Boni, Alessandra Gallo
The Conus genus includes around 500 species of marine mollusks with a peculiar production of venomous peptides known as conotoxins (CTX). Each species is able to produce up to 200 different biological active peptides. Common structure of CTX is the low number of amino acids stabilized by disulfide bridges and post-translational modifications that give rise to different isoforms. µ and µO-CTX are two isoforms that specifically target voltage-gated sodium channels. These, by inducing the entrance of sodium ions in the cell, modulate the neuronal excitability by depolarizing plasma membrane and propagating the action potential...
September 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28936810/phosphorylated-cxcr4-expression-has-a-positive-prognostic-impact-in-colorectal-cancer
#17
B Weixler, F Renetseder, I Facile, N Tosti, E Cremonesi, A Tampakis, T Delko, S Eppenberger-Castori, A Tzankov, G Iezzi, C Kettelhack, S D Soysal, U von Holzen, G C Spagnoli, L Terracciano, L Tornillo, Raoul A Droeser, S Däster
BACKGROUND: The CXCL12-CXCR4 chemokine axis plays an important role in cell trafficking as well as in tumor progression. In colorectal cancer (CRC), the chemokine receptor CXCR4 has been shown to be an unfavorable prognostic factor in some studies, however, the role of its activated (phosphorylated) form, pCXCR4, has not yet been evaluated. Here, we aimed to investigate the prognostic value of CXCR4 and pCXCR4 in a large cohort of CRC patients. PATIENTS AND METHODS: A tissue microarray (TMA) of 684 patient specimens of primary CRCs was analyzed by immunohistochemistry (IHC) for the expression of CXCR4 and pCXCR4 by tumor cells and tumor-infiltrating immune cells (TICs)...
September 21, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28925015/erosive-pustular-dermatosis-of-the-scalp-after-aplasia-cutis-congenita-in-a-9-year-old-patient-a-5-year-follow-up
#18
Raymond Fertig, Austin Maddy, Débora Cadore de Farias, Sandro Simão Corrêa Filho, Marcelo Rigatti, Antonella Tosti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory skin disease that occurs mainly in elderly adults with a history of trauma to the scalp, but a few cases of EPDS in children have been reported. We report a rare case of EPDS after aplasia cutis congenita in a child.
September 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28921841/in-a-randomized-trial-in-prostate-cancer-patients-dietary-protein-restriction-modifies-markers-of-leptin-and-insulin-signaling-in-plasma-extracellular-vesicles
#19
Erez Eitan, Valeria Tosti, Caitlin N Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P Mattson, Luigi Fontana
Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age-associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions...
December 2017: Aging Cell
https://www.readbyqxmd.com/read/28888124/sperm-viability-assessment-in-marine-invertebrates-by-fluorescent-staining-and-spectrofluorimetry-a-promising-tool-for-assessing-marine-pollution-impact
#20
Alessandra Gallo, Raffaele Boni, Elisabetta Tosti
The viability of spermatozoa is a crucial parameter to evaluate their quality that is an important issue in ecotoxicological studies. Here, a new method has been developed to rapidly determine the viability of spermatozoa in three marine invertebrates: the ascidian Ciona intestinalis, the sea urchin Paracentrotus lividus and the mollusc Mytilus galloprovincialis. This method employed the dual DNA fluorescent staining coupled with spectrofluorimetric analysis. The dual fluorescent staining used the SYBR-14 stained live spermatozoa and propidium iodide stained degenerated cells that had lost membrane integrity...
January 2018: Ecotoxicology and Environmental Safety
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