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https://www.readbyqxmd.com/read/29767494/genital-bowenoid-papulosis-the-variegated-dermoscopic-features
#1
Sabina Vaccari, Alessia Barisani, Emi Dika, Pier A Fanti, Antonietta D'antuono, Valeria Gaspari, Giulio Tosti, Annalisa Patrizi
No abstract text is available yet for this article.
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29765965/dermoscopy-of-yellow-concretions-on-axillary-hair
#2
Jessica Cervantes, Robert J Johr, Antonella Tosti
No abstract text is available yet for this article.
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29765961/efinaconazole-10-topical-solution-case-review-of-onychomycosis-patients-who-were-completely-cured-at-week-24
#3
Boni E Elewski, Antonella Tosti, Tina Lin
Background: Clinical studies with topical onychomycosis agents typically involve daily application over 48 weeks. Some patients are cured earlier; however, individual data are limited. Objective: The aim of this study was to assess baseline demographics/disposition of onychomycosis patients completely cured at week 24 following daily efinaconazole treatment. Methods: We conducted a week-24 case review of 2 identical, multicenter, randomized, double-blind, vehicle-controlled studies on 1,655 patients with mild-to-moderate onychomycosis...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29742195/longitudinal-melanonychia-biopsy-what-not-to-do
#4
Jorge Ocampo-Garza, Joana Mendes Bretas, Daiane Matana, Paula Jacomini Sobral, Curtis T Thompson, Martin Zaiac, Antonella Tosti
The nail matrix biopsy is an important technique in confirming or excluding a diagnosis of melanoma in a patient with longitudinal melanonychia. Dermatologists are the first-line diagnosticians for these pigmented lesions of the nail unit, however, for different reasons, some are reluctant to perform a nail biopsy. This case demonstrates how a poor biopsy technique resulted in a misdiagnosis in a patient with melanoma in situ. J Drugs Dermatol. 2018;17(5):587-588.
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29682736/medical-comorbidities-in-patients-with-lichen-planopilaris-a-retrospective-case-control-study
#5
Raymond M Fertig, Shasa Hu, Austin J Maddy, Alexandra Balaban, Nouf Aleid, Adam Aldahan, Antonella Tosti
BACKGROUND: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis. OBJECTIVES: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA). METHODS: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29660424/dermoscopic-features-of-onychotillomania-a-study-of-36-cases
#6
Austin John Maddy, Antonella Tosti
BACKGROUND: Onychotillomania is a nail-picking disorder characterized by nail dystrophy and abnormal morphology of the nail plate, nail bed, and periungual skin. OBJECTIVE: The purpose of this study was to describe the dermoscopic features of onychotillomania. METHODS: A retrospective study of the dermoscopy images of 36 patients affected by onychotillomania. The images were reviewed independently by both authors and a list of dermatoscopic findings was established...
April 13, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29582461/short-anagen-syndrome-case-series-and-literature-review
#7
Kate E Oberlin, Austin J Maddy, María Abril Martínez-Velasco, Norma Elizabeth Vázquez-Herrera, Lawrence A Schachner, Antonella Tosti
BACKGROUND/OBJECTIVES: Short anagen syndrome is a hair cycle disorder usually diagnosed in early childhood and characterized by short hair length due to short duration of the anagen phase. The objective was to review the presentation and demographic characteristics of short anagen syndrome and compare them with the most common differential diagnosis, loose anagen syndrome. METHODS: A retrospective review of eight children with short anagen syndrome was performed at the University of Miami Outpatient Dermatology Clinic...
March 26, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29577451/positive-jacquet-s-sign-in-traction-alopecia
#8
J Ancer-Arellano, A Tosti, C D Villarreal-Villarreal, S Chavez-Alvarez, J Ocampo-Candiani
A 32-year-old previous healthy woman was observed with a 3-year history of hair loss. On physical examination, she had decreased hair density and smooth padded alopecic patches on the occipital and parietal scalp. The fronto/temporal hair rim was preserved. A positive Jacquet's sign was present with easy formation of several folds in the occipito/parietal scalp; the pull test was negative. This article is protected by copyright. All rights reserved.
March 25, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29575469/the-effects-of-graded-caloric-restriction-xii-comparison-of-mouse-to-human-impact-on-cellular-senescence-in-the-colon
#9
Luigi Fontana, Sharon E Mitchell, Boshi Wang, Valeria Tosti, Thijmen van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S Early, Parcival Maissan, John R Speakman, Marco Demaria
Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear...
March 25, 2018: Aging Cell
https://www.readbyqxmd.com/read/29572359/mapping-transcription-factor-occupancy-using-minimal-numbers-of-cells-in-vitro-and-in-vivo
#10
Luca Tosti, James Ashmore, Boon Siang Nicholas Tan, Benedetta Carbone, Tapan K Mistri, Valerie Wilson, Simon R Tomlinson, Keisuke Kaji
The identification of transcription factor (TF) binding sites in the genome is critical to understanding gene regulatory networks (GRNs). While ChIP-seq is commonly used to identify TF targets, it requires specific ChIP-grade antibodies and high cell numbers, often limiting its applicability.<u>D</u>NA<u>a</u>denine<u>m</u>ethyltransferase<u>id</u>entification (DamID), developed and widely used in Drosophila , is a distinct technology to investigate protein-DNA interactions...
March 23, 2018: Genome Research
https://www.readbyqxmd.com/read/29566920/hair-and-nail-diseases-in-the-mature-patient
#11
Austin John Maddy, Antonella Tosti
The elderly population is growing, lifespans are increasing, and a greater emphasis on geriatric care is being implemented in hospital systems. With a higher percentage of the population living longer, hair and nail diseases associated with the advanced stages of life are becoming more prevalent. Common hair diseases in the elderly include androgenetic alopecia, senile alopecia, frontal fibrosing alopecia, and erosive pustular dermatosis of the scalp. Nail diseases associated with advanced age include onychomycosis, brittle nails, onychocryptosis, onychoclavus, onychogryphosis, subungual hematomas, subungual exostosis, myxoid cysts, and malignancies...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566852/role-of-medical-therapy-in-the-management-of-uterine-adenomyosis
#12
REVIEW
Silvia Vannuccini, Stefano Luisi, Claudia Tosti, Flavia Sorbi, Felice Petraglia
Adenomyosis is a benign uterine condition affecting women at various ages with different symptoms. The management of these patients is still controversial. Few clinical studies focusing on medical or surgical treatment for adenomyosis have been performed. No drug is currently labelled for adenomyosis and there are no specific guidelines to follow for the best management. Anyhow, medical treatments are effective in improving symptoms (pain, abnormal uterine bleeding and infertility). The rationale for using medical treatment is based on the pathogenetic mechanisms of adenomyosis: sex steroid hormones aberrations, impaired apoptosis, and increased inflammation...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29509837/genetic-profiling-using-plasma-derived-cell-free-dna-in-therapy-na%C3%A3-ve-hepatocellular-carcinoma-patients-a-pilot-study
#13
C K Y Ng, G G Di Costanzo, N Tosti, V Paradiso, M Coto-Llerena, G Roscigno, V Perrina, C Quintavalle, T Boldanova, S Wieland, G Marino-Marsilia, M Lanzafame, L Quagliata, G Condorelli, M S Matter, R Tortora, M H Heim, L M Terracciano, S Piscuoglio
Background: Hepatocellular carcinomas (HCCs) are not routinely biopsied, resulting in a lack of tumor materials for molecular profiling. Here we sought to determine if plasma-derived cell-free DNA (cfDNA) captures the genetic alterations of HCC in patients who have not undergone systemic therapy. Patients and methods: Frozen biopsies from the primary tumor and plasma were synchronously collected from 30 prospectively recruited, systemic treatment-naïve HCC patients...
March 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29466675/emerging-drugs-for-alopecia-areata-jak-inhibitors
#14
Matilde Iorizzo, Antonella Tosti
Alopecia Areata is a common form of non-scarring hair loss that usually starts abruptly with a very high psychological impact. Due to the still not completely understood etiopathogenesis, at present there is no treatment that can induce a permanent remission and there is no drug approved for the treatment of this disorder. Areas covered: Leading existing treatment are briefly overviewed and then ongoing research on Janus Kinases Inhibitors is discussed, reviewing trials with oral and topical formulations so as new opportunities for other forms of alopecia, such as cicatricial alopecia...
March 2018: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/29457019/platelet-rich-plasma-in-the-treatment-of-hair-disorders
#15
EDITORIAL
Antonella Tosti, Dimitris Rigopoulos
No abstract text is available yet for this article.
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29457011/trichoscopic-features-of-linear-morphea-on-the-scalp
#16
David Saceda-Corralo, Antonella Tosti
Linear scleroderma en coup de sabre (LSCS) is the most common form of morphea on the scalp and its trichoscopic features have not been described yet. We report 2 adult women with LSCS with distinct dermoscopic findings. They both had an atrophic well-defined linear patch of alopecia on the frontotemporal scalp. Dermoscopy showed loss of follicular openings on a whitish skin surface; scattered black dots, broken hairs, and pili torti; and short thick linear and branching tortuous vessels on the periphery of the lesion...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29454738/-satellite-center-of-human-milk-analysis-of-cost-reduction
#17
L Affumicato, T Sánchez Tamayo, M G Espinosa Fernandez, M Peña Caballero, C E Ruiz Morcillo, R Acebes Tosti, E Salguero García
INTRODUCTION: Donor milk is the second best alternative for a newborn after the mother's own milk, especially when the baby is a premature or a sick child since this milk has the advantage of protecting against necrotizing enterocolitis. There are currently 13 milk banks in Spain, however this is not sufficient to supply all Spanish neonatal units with donor milk. In order to bring donor milk to the babies in Neonatal Unit of the Regional University Hospital of Malaga, a Satellite Centre (CS) was created in 2012, depending on the Milk Bank of Virgen de las Nieves Hospital in Granada...
January 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29438985/inhibition-of-ddr1-bcr-signalling-by-nilotinib-as-a-new-therapeutic-strategy-for-metastatic-colorectal-cancer
#18
Maya Jeitany, Cédric Leroy, Priscillia Tosti, Marie Lafitte, Jordy Le Guet, Valérie Simon, Debora Bonenfant, Bruno Robert, Fanny Grillet, Caroline Mollevi, Safia El Messaoudi, Amaëlle Otandault, Lucile Canterel-Thouennon, Muriel Busson, Alain R Thierry, Pierre Martineau, Julie Pannequin, Serge Roche, Audrey Sirvent
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. Here, we show that nilotinib, a clinically approved drug for chronic myeloid leukaemia, strongly inhibits human CRC cell invasion in vitro and reduces their metastatic potential in intrasplenic tumour mouse models. Nilotinib acts by inhibiting the kinase activity of DDR1, a receptor tyrosine kinase for collagens, which we identified as a RAS-independent inducer of CRC metastasis. Using quantitative phosphoproteomics, we identified BCR as a new DDR1 substrate and demonstrated that nilotinib prevents DDR1-mediated BCR phosphorylation on Tyr177, which is important for maintaining β-catenin transcriptional activity necessary for tumour cell invasion...
April 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29393881/the-role-of-photodynamic-therapy-in-the-treatment-of-vulvar-intraepithelial-neoplasia
#19
REVIEW
Giulio Tosti, Anna Daniela Iacobone, Eleonora Petra Preti, Sabina Vaccari, Alessia Barisani, Elisabetta Pennacchioli, Carmen Cantisani
BACKGROUND: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50-70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical morbidities related to extensive surgery, several less aggressive treatment modalities have been proposed since the late 1970s. Photodynamic therapy is an effective and safe treatment for cutaneous non-melanoma skin cancer, with favorable cosmetic outcomes...
February 2, 2018: Biomedicines
https://www.readbyqxmd.com/read/29356108/polarized-transilluminating-dermoscopy
#20
COMMENT
Francesco Lacarrubba, Antonella Tosti
No abstract text is available yet for this article.
January 2018: Pediatric Dermatology
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