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https://www.readbyqxmd.com/read/27904832/frontal-fibrosing-alopecia-treatment-options
#1
Raymond Fertig, Antonella Tosti
Frontal fibrosing alopecia (FFA) is a rare dermatologic disease that causes scarring and hair loss and is increasing in prevalence worldwide. FFA patients typically present with hair loss in the frontal scalp region and eyebrows which may be associated with sensations of itching or burning. FFA is a clinically distinct variant of lichen planopilaris (LPP) that affects predominantly postmenopausal women, although men and premenopausal women may also be affected. Early diagnosis and prompt treatment are necessary to prevent definitive scarring and permanent hair loss...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27886828/wrist-arthroscopy-for-athletic-injuries
#2
REVIEW
Rick Tosti, Eon Shin
Management of hand and wrist injuries for athletes often places emphasis on an expeditious return to sport. Arthroscopic techniques have the advantage of directly visualizing joint derangements and correcting them via a minimally invasive approach. This article discusses the evaluation and management of common wrist injuries treated with arthroscopy in athletes, including scapholunate and lunotriquetral injury, triangular fibrocartilage complex tears, hamatolunate impingement, and arthroscopic-assisted reduction of wrist fractures...
February 2017: Hand Clinics
https://www.readbyqxmd.com/read/27870094/patch-test-nails
#3
Teresa Oranges, Nouf Aleid, Sara Faleri, Antonella Tosti
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27858889/correlates-of-infection-and-molecular-characterization-of-blood-borne-hiv-hcv-and-hbv-infections-in-hiv-1-infected-inmates-in-italy-an-observational-cross-sectional-study
#4
Nunzia Sanarico, Stefania D'Amato, Roberto Bruni, Claudia Rovetto, Emanuela Salvi, Patrizia Di Zeo, Paola Chionne, Elisabetta Madonna, Giulio Pisani, Angela Costantino, Michele Equestre, Maria E Tosti, Alessandra Cenci, Maria T Maggiorella, Leonardo Sernicola, Emanuele Pontali, Alfredo Pansera, Rocco Quattrocchi, Sergio Carbonara, Fabio Signorile, Lorenzo Antonio Surace, Guido Federzoni, Elisa Garlassi, Giulio Starnini, Roberto Monarca, Sergio Babudieri, Maria Rapicetta, Maria G Pompa, Anna Caraglia, Barbara Ensoli, Anna R Ciccaglione, Stefano Buttò
Coinfection of blood-borne hepatitis B and hepatitis C viruses (HBV and HCV, respectively) in human immunodeficiency virus type 1 (HIV-1)-positive individuals frequently occurs in inmate population and peculiar viral strains and patterns of virological markers may be observed.Plasma from 69 HIV-1-positive inmates was obtained from 7 clinical centers connected with correctional centers in different towns in Italy. HIV, HBV, and HCV markers were tested by commercial assays. Virus genotyping was carried out by sequencing the protease and reverse transcriptase-encoding region (PR-RT region) for HIV and a region encompassing the NS5B gene for HCV and subsequent phylogenetic analysis...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855356/hmga1-expression-in-human-hepatocellular-carcinoma-correlates-with-poor-prognosis-and-promotes-tumor-growth-and-migration-in-in-vitro-models
#5
Mariacarla Andreozzi, Cristina Quintavalle, David Benz, Luca Quagliata, Matthias Matter, Diego Calabrese, Nadia Tosti, Christian Ruiz, Francesca Trapani, Luigi Tornillo, Alfredo Fusco, Markus H Heim, Charlotte Ky Ng, Pierlorenzo Pallante, Luigi M Terracciano, Salvatore Piscuoglio
BACKGROUND: HMGA1 is a non-histone nuclear protein that regulates cellular proliferation, invasion and apoptosis and is overexpressed in many carcinomas. In this study we sought to explore the expression of HMGA1 in HCCs and cirrhotic tissues, and its effect in in vitro models. METHODS: We evaluated HMGA1 expression using gene expression microarrays (59 HCCs, of which 37 were matched with their corresponding cirrhotic tissue and 5 normal liver donors) and tissue microarray (192 HCCs, 108 cirrhotic tissues and 79 normal liver samples)...
November 14, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27843933/onychomycosis-practical-approaches-to-minimize-relapse-and-recurrence
#6
REVIEW
Antonella Tosti, Boni E Elewski
INTRODUCTION: Toenail onychomycosis is a common disease in which treatment options are limited and treatment failures and disease recurrence are frequently encountered. It usually requires many months of treatment, and recurrence may occur in more than half of the patients within 1 year or more after the infection has been eradicated. Data on long-term treatment, follow-up and recurrence are limited. OBJECTIVE: Our objective is to interpret these data and recommend practical approaches that should minimize recurrence based on our clinical experience...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27843915/trachyonychia-and-twenty-nail-dystrophy-a-comprehensive-review-and-discussion-of-diagnostic-accuracy
#7
REVIEW
Audrey A Jacobsen, Antonella Tosti
BACKGROUND/AIMS: The term trachyonychia, also known as twenty-nail dystrophy, is used to describe thin, brittle nails with excessive longitudinal ridging. The term twenty-nail dystrophy has been incorrectly applied to other conditions that can affect all twenty nails. Therefore, we have conducted a comprehensive review of the clinical features of trachyonychia and have included a discussion regarding the diagnostic accuracy of this condition in the literature. METHODS: In November and December 2015, we conducted a thorough literature search using the following search terms: 'trachyonychia', 'twenty nail dystrophy', and 'sandpaper nails'...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27833715/large-sublingual-dermoid-cyst-a-case-of-mandibular-prognathism
#8
Pablo Berbel, Alejandro Ostrosky, Franco Tosti
Dermoid cysts are unusual neoplasms and can occur in every part of the human body. They represent only 6.9% of all dermoid cysts in the head and neck region; in the oral cavity, the incidence is low, approximately 1.6% of all dermoid cysts. Our aim is to present an unusual case of a large sublingual dermoid cyst with mandibular prognathism caused by cyst growth. We reported a case of a large sublingual dermoid cyst in an 8-year-old female patient. A bibliographic research from 1937 to 2013 is reviewed and we found only three cases of mandibular deformity, of which only one was a dermoid cyst of the floor of the mouth...
November 2016: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/27787643/tinea-unguium-diagnosis-and-treatment-in-practice
#9
Daniel Asz-Sigall, Antonella Tosti, Roberto Arenas
Onychomycosis is caused by dermatophytes, yeasts or non-dermatophyte molds; when caused by dermatophytes, it is called tinea unguium. The main etiological agents are Trichophyton rubrum and Trichophyton interdigitale. The most frequent types are distal and lateral subungual onychomycosis. Diagnosis usually requires mycological laboratory confirmation. Dermoscopy can be helpful and also biopsy is an excellent diagnostic method in uncommon cases or when mycological test is negative. Treatment must be chosen according to clinical type, number of affected nails and severity...
October 27, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27749350/spine-surgery-and-blood-loss-systematic-review-of-clinical-evidence
#10
Dafna Willner, Valeria Spennati, Shelly Stohl, Giulia Tosti, Simone Aloisio, Federico Bilotta
Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraoperative and postoperative blood loss. The aim of this systematic review is to report clinical evidence on the relationship between intraoperative blood loss (primary outcome) and on transfusion requirements and postoperative complications (secondary outcomes) in patients undergoing spine surgery...
November 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27681274/nail-changes-of-systemic-amyloidosis-after-bone-marrow-transplantation-in-a-patient-with-multiple-myeloma
#11
Kate E Oberlin, Erin X Wei, Jeong Hee Cho-Vega, Antonella Tosti
No abstract text is available yet for this article.
September 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27668904/a-family-cluster-of-hepatitis-a-virus-due-to-an-uncommon-ia-strain-circulating-in-campania-southern-italy-not-associated-with-raw-shellfish-or-berries-a-wake-up-call-to-implement-vaccination-against-hepatitis-a
#12
Grazia Tosone, Silvia Mascolo, Roberto Bruni, Stefania Taffon, Michele Equestre, Maria Elena Tosti, Anna Rita Ciccaglione, Fiorella Martucci, Alfonso Liberti, Maria Donata Iannece, Raffaele Orlando
Hepatitis A virus is a widely occurring disease, with different prevalence rates between countries in the North and West and those in the South and East. In Italy endemicity is low/medium, but not homogeneously distributed: in the northern/central regions a large hepatitis A outbreak due to genotype IA, related to the consumption of contaminated mixed frozen berries, occurred between 2013 and 2014, whereas in southern Italian regions recurrent outbreaks of hepatitis A, due to the IB genotype, still result from consumption of raw seafood...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27649353/pediatric-contact-dermatitis-registry-inaugural-case-data
#13
Alina Goldenberg, Nico Mousdicas, Nanette Silverberg, Douglas Powell, Janice L Pelletier, Jonathan I Silverberg, Jonathan Zippin, Luz Fonacier, Antonella Tosti, Leslie Lawley, Mary Wu Chang, Andrew Scheman, Gary Kleiner, Judith Williams, Kalman Watsky, Cory A Dunnick, Rachel Frederickson, Catalina Matiz, Keri Chaney, Tracy S Estes, Nina Botto, Michelle Draper, Leon Kircik, Aida Lugo-Somolinos, Brian Machler, Sharon E Jacob
BACKGROUND: Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed. OBJECTIVE: The aim was to quantify patch test results from providers evaluating US children. METHODS: The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016)...
September 2016: Dermatitis
https://www.readbyqxmd.com/read/27646758/casts-and-pseudocasts
#14
Isabella Doche, Colombina Vincenzi, Antonella Tosti
No abstract text is available yet for this article.
October 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27580311/acute-hair-matting-case-report-and-trichoscopy-findings
#15
S S Martins, L S Abraham, I Doche, B M Piraccini, C Vincenzi, A Tosti
Acute hair matting (AHM) is a rare condition presenting as a compact mass with irregular twists and severely entangled hairs abruptly formed in the scalp. First reported as "plica neuropathica" by Le Page in 1884, the condition was thought to be due to hysteria(1) . However, the term "plica polonica" was also very prevalent in Poland in the 19(th) century, when the polish custom of wearing tight fur caps and not washing the hair contributed to a filthy and malodorous compact mass, usually associated with lice infection and inflammation in the scalp (2) ...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27567427/urocortin-and-corticotrophin-releasing-hormone-receptor-type-2-mrna-are-highly-expressed-in-deep-infiltrating-endometriotic-lesions
#16
Patrizia Carrarelli, Alice Luddi, Lucia Funghi, Felice Arcuri, Frederic Batteux, Cynthia Dela Cruz, Claudia Tosti, Fernando M Reis, Charles Chapron, Felice Petraglia
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) are the most severe forms of endometriosis, but different pathogenetic mechanisms and clinical symptoms distinguish these two forms. Corticotrophin-releasing hormone (CRH) and urocortin (Ucn) are endometrial neuropeptides involved in tissue differentiation and inflammation. The expression of CRH, Ucn, Ucn2, CRH-receptors (type-1 and type-2) and inflammatory enzymes phospholipase-A2 group IIA (PLA2G2A) and cycloxygenase-2 (COX2) were evaluated in OMA (n = 22) and DIE (n = 26)...
October 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27554257/androgenetic-alopecia-an-update-of-treatment-options
#17
REVIEW
Yanna Kelly, Aline Blanco, Antonella Tosti
Androgenetic alopecia (AGA) is characterized by a non-scarring progressive miniaturization of the hair follicle in predisposed men and women with a pattern distribution. Although AGA is a very prevalent condition, approved therapeutic options are limited. This article discusses the current treatment alternatives including their efficacy, safety profile, and quality of evidence. Finasteride and minoxidil for male androgenetic alopecia and minoxidil for female androgenetic alopecia still are the therapeutic options with the highest level evidence...
September 2016: Drugs
https://www.readbyqxmd.com/read/27544442/calorie-restriction-in-humans-an-update
#18
Jasper Most, Valeria Tosti, Leanne M Redman, Luigi Fontana
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials indicate that CR in humans results in some of the same metabolic and molecular adaptations that have been shown to improve health and retard the accumulation of molecular damage in animal models of longevity. In particular, moderate CR in humans ameliorates multiple metabolic and hormonal factors that are implicated in the pathogenesis of type 2 diabetes, cardiovascular diseases, and cancer, the leading causes of morbidity, disability and mortality...
August 17, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27503693/hormonal-therapy-for-endometriosis-from-molecular-research-to-bedside
#19
Claudia Tosti, Antonella Biscione, Giuseppe Morgante, Giuseppe Bifulco, Stefano Luisi, Felice Petraglia
Endometriotic lesions are associated with hormonal imbalance, including increased estrogen synthesis, metabolism and progesterone resistance. These hormonal changes cause increased proliferation, inflammation, pain and infertility. Hormonal imbalances are targets for treatment. Therapeutic strategies and innovations of hormonal drugs for endometriosis are increasing. Acting on estrogen receptors are hormonal drugs decreasing systemic and local estrogen synthesis (GnRH analogs, GnRH antagonists, Aromatase inhibitors) or estrogen activity (selective estrogen receptor modulators)...
May 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27486901/hmga1-silencing-reduces-stemness-and-temozolomide-resistance-in-glioblastoma-stem-cells
#20
Marianna Colamaio, Nadia Tosti, Francesca Puca, Alessia Mari, Rosaria Gattordo, Yalçın Kuzay, Antonella Federico, Anna Pepe, Daniela Sarnataro, Elvira Ragozzino, Maddalena Raia, Hidenari Hirata, Marica Gemei, Koshi Mimori, Luigi Del Vecchio, Sabrina Battista, Alfredo Fusco
OBJECTIVE: Glioblastoma multiforme (GBM) develops from a small subpopulation of stem-like cells, which are endowed with the ability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. These cells are resistant to conventional chemo- and radiotherapy and are hence also responsible for tumor recurrence. HMGA1 overexpression has been shown to correlate with proliferation, invasion, and angiogenesis of GBMs and to affect self-renewal of cancer stem cells from colon cancer...
October 2016: Expert Opinion on Therapeutic Targets
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