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https://www.readbyqxmd.com/read/29128463/objective-outcome-measures-collecting-meaningful-data-on-alopecia-areata
#1
Elise A Olsen, Janet Roberts, Leonard Sperling, Antonella Tosti, Jerry Shapiro, Amy McMichael, Wilma Bergfeld, Valerie Callender, Paradi Mirmirani, Ken Washenik, David Whiting, George Cotsarelis, Maria Hordinsky
BACKGROUND: Although alopecia areata is a common disorder, it has no FDA approved treatment and evidence-based therapeutic data is lacking. OBJECTIVE: To develop guidelines for the diagnosis, evaluation, assessment, response criteria and endpoints for alopecia areata. METHODS: Literature review and expert opinion of a group of dermatologists specializing in hair disorders. RESULTS: Standardized methods of assessing and tracking hair loss and growth including new scoring techniques, response criteria and endpoints in alopecia areata are presented...
November 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29064882/crossfit-associated-allergic-contact-dermatitis
#2
Jennifer A Ledon, Antonella Tosti
No abstract text is available yet for this article.
November 2017: Dermatitis
https://www.readbyqxmd.com/read/29061368/dermoscopic-technique-for-the-evaluation-of-the-nail-unit
#3
Jorge Ocampo-Garza, Paula Jacomini Sobral, Joana Mendes Bretas, Daiane Matana, Antonella Tosti
No abstract text is available yet for this article.
October 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28968938/insights-into-the-cuo-nanoparticle-ecotoxicity-with-suitable-marine-model-species
#4
A Rotini, A Gallo, I Parlapiano, M T Berducci, R Boni, E Tosti, E Prato, C Maggi, A M Cicero, L Migliore, L Manfra
Metal oxide nanoparticles, among them copper oxide nanoparticles (CuO NPs), are widely used in different applications (e.g. batteries, gas sensors, superconductors, plastics and metallic coatings), increasing their potential release in the environment. In aquatic matrix, the behavior of CuO NPs may strongly change, depending on their surface charge and some physical-chemical characteristics of the medium (e.g. ionic strength, salinity, pH and natural organic matter content). Ecotoxicity of CuO NPs to aquatic organisms was mainly studied on freshwater species, few tests being performed on marine biota...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28960450/pterygium-inversum-unguis-secondary-to%C3%A2-gel-polish
#5
J Cervantes, M Sanchez, A E Eber, M Perper, A Tosti
BACKGROUND: Pterygium inversum unguis (PIU) is characterized by the abnormal adherence of the hyponychium to the ventral surface of the nail plate. It can be both unsightly and painful, resulting in morbidity for patients. Gel polish is a popular nail cosmetic that has been reported to cause several complications. PIU may be another adverse outcome. OBJECTIVE: To highlight a newly-recognized adverse effect of a popular beauty technique. METHODS: This retrospective and prospective case series reports 17 women who developed PIU after gel polish use...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28937587/%C3%A2%C2%B5-conotoxins-modulating-sodium-currents-in-pain-perception-and-transmission-a-therapeutic-potential
#6
REVIEW
Elisabetta Tosti, Raffaele Boni, Alessandra Gallo
The Conus genus includes around 500 species of marine mollusks with a peculiar production of venomous peptides known as conotoxins (CTX). Each species is able to produce up to 200 different biological active peptides. Common structure of CTX is the low number of amino acids stabilized by disulfide bridges and post-translational modifications that give rise to different isoforms. µ and µO-CTX are two isoforms that specifically target voltage-gated sodium channels. These, by inducing the entrance of sodium ions in the cell, modulate the neuronal excitability by depolarizing plasma membrane and propagating the action potential...
September 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28936810/phosphorylated-cxcr4-expression-has-a-positive-prognostic-impact-in-colorectal-cancer
#7
B Weixler, F Renetseder, I Facile, N Tosti, E Cremonesi, A Tampakis, T Delko, S Eppenberger-Castori, A Tzankov, G Iezzi, C Kettelhack, S D Soysal, U von Holzen, G C Spagnoli, L Terracciano, L Tornillo, Raoul A Droeser, S Däster
BACKGROUND: The CXCL12-CXCR4 chemokine axis plays an important role in cell trafficking as well as in tumor progression. In colorectal cancer (CRC), the chemokine receptor CXCR4 has been shown to be an unfavorable prognostic factor in some studies, however, the role of its activated (phosphorylated) form, pCXCR4, has not yet been evaluated. Here, we aimed to investigate the prognostic value of CXCR4 and pCXCR4 in a large cohort of CRC patients. PATIENTS AND METHODS: A tissue microarray (TMA) of 684 patient specimens of primary CRCs was analyzed by immunohistochemistry (IHC) for the expression of CXCR4 and pCXCR4 by tumor cells and tumor-infiltrating immune cells (TICs)...
September 21, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28925015/erosive-pustular-dermatosis-of-the-scalp-after-aplasia-cutis-congenita-in-a-9-year-old-patient-a-5-year-follow-up
#8
Raymond Fertig, Austin Maddy, Débora Cadore de Farias, Sandro Simão Corrêa Filho, Marcelo Rigatti, Antonella Tosti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory skin disease that occurs mainly in elderly adults with a history of trauma to the scalp, but a few cases of EPDS in children have been reported. We report a rare case of EPDS after aplasia cutis congenita in a child.
September 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28921841/in-a-randomized-trial-in-prostate-cancer-patients-dietary-protein-restriction-modifies-markers-of-leptin-and-insulin-signaling-in-plasma-extracellular-vesicles
#9
Erez Eitan, Valeria Tosti, Caitlin N Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P Mattson, Luigi Fontana
Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age-associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increases insulin sensitivity and suppresses prostate cancer cell tumor growth in animal models, providing a rationale for clinical trials. We sought to demonstrate that biomarkers derived from plasma extracellular vesicles (EVs) reflect systemic leptin and insulin signaling and respond to dietary interventions...
December 2017: Aging Cell
https://www.readbyqxmd.com/read/28888124/sperm-viability-assessment-in-marine-invertebrates-by-fluorescent-staining-and-spectrofluorimetry-a-promising-tool-for-assessing-marine-pollution-impact
#10
Alessandra Gallo, Raffaele Boni, Elisabetta Tosti
The viability of spermatozoa is a crucial parameter to evaluate their quality that is an important issue in ecotoxicological studies. Here, a new method has been developed to rapidly determine the viability of spermatozoa in three marine invertebrates: the ascidian Ciona intestinalis, the sea urchin Paracentrotus lividus and the mollusc Mytilus galloprovincialis. This method employed the dual DNA fluorescent staining coupled with spectrofluorimetric analysis. The dual fluorescent staining used the SYBR-14 stained live spermatozoa and propidium iodide stained degenerated cells that had lost membrane integrity...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28879194/an-unusual-case-of-contact-dermatitis
#11
Olivia B Hughes, Andrea D Maderal, Antonella Tosti
We report a case of acute psoriasiform contact dermatitis of the forehead and scalp related to the use of a low-laser light cap. The patient had a positive patch test to dimethylol dihydroxyethyleneurea (DMDE), methylisothiazolinone, kathon CG, and cobalt. We believe that DMDE in the fabric of the cap was responsible for the allergic contact dermatitis in this case as the lesions resolved with cessation of cap use.
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28879187/clinical-and-dermoscopic-features-of-the-scalp-in-31-patients-with-dermatomyositis
#12
Julio C Jasso-Olivares, Antonella Tosti, Mariya Miteva, Judith Domínguez-Cherit, José M Díaz-González
BACKGROUND: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described. OBJECTIVE: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM. METHODS: We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year...
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28872201/confocal-microscopy-in-the-diagnosis-of-fibreglass-dermatitis
#13
Ariel E Eber, Margaret Sanchez, Nayoung Lee, Marina Perper, Jessica Cervantes, Antonella Tosti
No abstract text is available yet for this article.
October 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28859221/optical-coherence-tomography-for-the-investigation-of-frontal-fibrosing-alopecia
#14
Norma Elizabeth Vazquez-Herrera, Ariel E Eber, Maria Abril Martinez-Velasco, Marina Perper, Jessica Cervantes, Sebastian H Verne, Robert J Magno, Keyvan Nouri, Antonella Tosti
BACKGROUND: FFA is a cicatricial alopecia that affects the frontotemporal hairline, eyebrows, and body hair. OCT is a non-invasive imaging technique useful in understanding skin architecture and vascularization. OBJECTIVE: To describe structural and vascular findings in FFA using OCT. METHODS: This was a case-control study conducted from the months of December 2016-February 2017. The study was IRB approved and conducted at the University of Miami Hospital outpatient dermatology hair and nail clinic in Miami, FL...
August 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28852198/extracellular-vesicles-as-potential-biomarkers-of-acute-graft-vs-host-disease
#15
G Lia, L Brunello, S Bruno, A Carpanetto, P Omedè, M Festuccia, L Tosti, E Maffini, L Giaccone, M Arpinati, G Ciccone, M Boccadoro, A Evangelista, G Camussi, B Bruno
Acute graft-vs-host disease (GVHD) is a serious complication after allografting. We carried out an exploratory study to investigate a potential correlation of surface antigens on extracellular vesicles (EVs) and acute GVHD. EVs were extracted from serum samples from 41 multiple myeloma patients who underwent allografting. EVs were characterized by flow cytometry using a panel of 13 antibodies against specific membrane proteins that were reported to be predictive of acute GVHD. We observed a correlation between three potential biomarkers expressed on EV surface and acute GVHD onset by both logistic regression analysis and Cox proportional hazard model...
August 30, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28804956/spontaneous-regression-of-a-nail-matrix-melanocytic-nevus-in-a-child
#16
Austin John Maddy, Antonella Tosti
A 14-year-old Hispanic boy presented with a 0.25-mm wide, sharply demarcated, dark brown band of longitudinal melanonychia of the left thumbnail. A clinical diagnosis of nail matrix nevus was made and the boy was scheduled for follow-up. The band showed proximal fading after 6 months and had completely faded after 11 months, with the proximal nail fold showing small dark brown dots on dermoscopy. We documented the spontaneous regression of melanonychia over 11 months.
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28763738/cost-effectiveness-of-simulation-based-team-training-in-obstetric-emergencies-tosti-study
#17
J van de Ven, G J van Baaren, A F Fransen, P J van Runnard Heimel, B W Mol, S G Oei
OBJECTIVE: Team training is frequently applied in obstetrics. We aimed to evaluate the cost-effectiveness of obstetric multi-professional team training in a medical simulation centre. STUDY DESIGN: We performed a model-based cost-effectiveness analysis to evaluate four strategies for obstetric team training from a hospital perspective (no training, training without on-site repetition and training with 6 month or 3-6-9 month repetition). Data were retrieved from the TOSTI study, a randomised controlled trial evaluating team training in a medical simulation centre...
July 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28742031/patient-specific-left-ventricular-flow-simulations-from-transthoracic-echocardiography-robustness-evaluation-and-validation-against-ultrasound-doppler-and-magnetic-resonance-imaging
#18
David Larsson, Jeannette H Spuhler, Sven Petersson, Tim Nordenfur, Massimiliano Colarieti-Tosti, Johan Hoffman, Reidar Winter, Matilda Larsson
The combination of medical imaging with computational fluid dynamics (CFD) has enabled the study of 3D blood flow on a patient-specific level. However, with models based on gated high-resolution data, the study of transient flows, and any model implementation into routine cardiac care, is challenging. The present paper presents a novel pathway for patient-specific CFD modelling of the left ventricle (LV), using 4D transthoracic echocardiography (TTE) as input modality. To evaluate the clinical usability, two sub-studies were performed...
July 21, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28738295/does-the-effect-of-one-day-simulation-team-training-in-obstetric-emergencies-decline-within-one-year-a-post-hoc-analysis-of-a-multicentre-cluster-randomised-controlled-trial
#19
J van de Ven, A F Fransen, E Schuit, P J van Runnard Heimel, B W Mol, S G Oei
Does the effect of one-day simulation team training in obstetric emergencies decline within one year? A post-hoc analysis of a multicentre cluster randomised controlled trial. J van de Ven, AF Fransen, E Schuit, PJ van Runnard Heimel, BW Mol, SG Oei OBJECTIVE: To investigate whether the effect of a one-day simulation-based obstetric team training on patient outcome changes over time. STUDY DESIGN: Post-hoc analysis of a multicentre, open, randomised controlled trial that evaluated team training in obstetrics (TOSTI study)...
September 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28703349/airborne-contact-dermatitis-caused-by-fragrance-diffusers-in-uber-cars
#20
Marina Perper, Jessica Cervantes, Ariel E Eber, Antonella Tosti
No abstract text is available yet for this article.
August 2017: Contact Dermatitis
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