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James Owen Robinson, Geoffrey Wallace Coombs, David John Speers, Terillee Keehner, Anthony David Keil, Victoria D'Abrera, Peter Boan, Stanley Pang
Following the reported link between heater-cooler unit (HCU) colonisation with Mycobacterium chimaera and endocarditis, mycobacterial sampling of all HCUs in use in Western Australia was initiated from August 2015, revealing M. chimaera colonisation in 10 of 15 HCUs. After M. chimaera was isolated from a pleural biopsy from a cardiothoracic patient who may have been exposed to a colonised HCU, a whole genome sequencing investigation was performed involving 65 specimens from 15 HCUs across five hospitals to assess if this infection was related to the HCU...
November 17, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Marc J Struelens, Diamantis Plachouras
No abstract text is available yet for this article.
November 17, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Shereen Katrak, Lawrence P Park, Christopher Woods, Andrew Muir, Charles Hicks, Susanna Naggie
Background.  Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and the primary cause of liver transplantation in the United States, and coinfection with human immunodeficiency virus (HIV) increases the risk of comorbidities. However, healthcare utilization (HCU) patterns among HIV/HCV-coinfected patients are poorly understood. This study compared the rates of HCU and reasons for hospital admission among HCV-infected, HIV-infected, and HIV/HCV-coinfected veterans. Methods.  Hepatitis C virus- and HIV-infected and HIV/HCV-coinfected veterans in care with the Department of Veterans Affairs (VA) from 1998 to 2009 (n = 335 371, n = 28 179, n = 13 471, respectively) were identified by HIV- and HCV-associated International Classification of Diseases, Ninth Revision codes from the clinical case registry...
September 2016: Open Forum Infectious Diseases
Kathryn D Winters, Stephanie Toth-Manikowski, Carol Martire, Tariq Shafi
BACKGROUND: Correctly assessing and managing volume status are critical elements of daily care for patients managed by nephrologists. However, intravascular volume is difficult to assess by physical examination alone. METHODS: We present vignettes illustrating the potential for using hand-carried ultrasound (HCU) to improve volume assessment in common clinical scenarios faced by the renal consultant in the hospital setting. These include patients with acute kidney injury and patients treated with hemodialysis...
July 2016: Medicine (Baltimore)
Sarah Walker, Wilma M Hopman, Meg E Carley, Elizabeth G Mann, Elizabeth G VanDenKerkhof
Background. Pain while waiting for surgery may increase healthcare utilization (HCU) preoperatively. Objective. Examine the association between preoperative pain and HCU in the year prior to gynecological surgery. Methods. 590 women waiting for surgery in a Canadian tertiary care centre were asked to report on HCU in the year before surgery. Pain was assessed using the Brief Pain Inventory. Results. 33% reported moderate to severe pain intensity and interference in the week before surgery. Sixty-one percent (n = 360) reported a total of 2026 healthcare visits, with 21% (n = 126) reporting six or more visits in the year before surgery...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
Jamie Wood, Siobhain Mulrennan, Kylie Hill, Nola Cecins, Sue Morey, Sue Jenkins
INTRODUCTION: A significant proportion (15%, n = 28) of the adults with cystic fibrosis (CF) in Western Australia (WA) live in rural and remote areas and have difficulty accessing specialist care at the state adult CF centre, located in Perth. We aimed to increase access by offering telehealth clinics, and evaluate the impact on health outcomes. METHODS: Telehealth clinics were offered via videoconference over a 12-month period, with uptake and satisfaction measured at the end of the intervention...
July 20, 2016: Journal of Telemedicine and Telecare
Jun Cao, Yihong Chen, Min Jin, Qian Ren
Toll receptors play an important role in the innate immunity of invertebrates. All reported Tolls have only one Toll/interleukin-1 receptor (TIR) domain at the C-terminal. In this study, numerous Tolls with tandem TIRs at the C-terminal were found in molluscs. Such Tolls presented an extra TIR (TIR-1) compared with Toll-I. Thus, Toll-I might be the ancestor of tandem TIRs containing Toll. To test this hypothesis, 83 Toll-I and Toll-2 (most have two TIRs, but others seem to be the evolutionary intermediates) genes from 29 shellfish species were identified...
June 2016: Royal Society Open Science
Allysha C Maragh-Bass, Christine Powell, Ju Park, Colin Flynn, Danielle German
Persons who inject drugs (PWID) may have less access to, and utilization of, health-care services, and African American PWID may be less likely than other racial groups to utilize health care in the United States. The present study evaluated the prevalence of health-care utilization (HCU) among a cohort of African American PWID in Baltimore. Data were from the 2012 Baltimore National HIV Behavioral Surveillance study. Participants were adult PWID and recruited using respondent-driven sampling (RDS). They completed a comprehensive sociobehavioral survey and voluntary HIV test with trained study interviewers...
July 12, 2016: Journal of Ethnicity in Substance Abuse
Akke-Nynke van der Meer, Henk Pasma, Wilma Kempenaar-Okkema, Jo-Anneke Pelinck, Myrte Schutten, Huib Storm, Anneke Ten Brinke
Patients with uncontrolled asthma report ongoing symptoms, poor quality-of-life and extensive healthcare use (HCU) and might benefit from management by a specialised severe asthma team. It is unknown whether a one-time evaluation by asthma experts, without long-term supervision by a specialised team, provides favourable outcomes. We evaluated asthma control (Asthma Control Questionnaire; ACQ), quality-of-life (Asthma-related Quality of Life Questionnaire; AQLQ) and HCU before and 1 year after a 1-day visit programme in a severe asthma centre, including a multidisciplinary assessment resulting in a personalised management plan to be implemented by patients own pulmonologists...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Jürgen G Okun, Hongying Gan-Schreier, Tawfeq Ben-Omran, Kathrin V Schmidt, Junmin Fang-Hoffmann, Gwendolyn Gramer, Ghassan Abdoh, Noora Shahbeck, Hilal Al Rifai, Abdul Latif Al Khal, Gisela Haege, Chuan-Chi Chiang, David C Kasper, Bridget Wilcken, Peter Burgard, Georg F Hoffmann
BACKGROUND: In classical homocystinuria (HCU, MIM# 236200) due to the deficiency of cystathionine β-synthase (EC there is a clear evidence for the success of early treatment. The aim of this study was to develop and evaluate a two-tier strategy for HCU newborn screening. METHODS: We reevaluated data from our newborn screening programme for Qatar in a total number of 125,047 neonates including 30 confirmed HCU patients. Our hitherto existing screening strategy includes homocysteine (Hcy) measurements in every child, resulting in a unique dataset for evaluation of two-tier strategies...
June 21, 2016: JIMD Reports
Keisuke Kameda, Kazuhiro Watarai, Kenji Takahashi, Tomohisa Shoko, Masayoshi Koinuma, Goro Ikushima
Since 2012, Matsudo City Hospital has increased the number of pharmacists stationed in the ward on weekday mornings at the emergency care center, the intensive care unit (ICU) and the high care unit (HCU). Multidisciplinary joint meetings and joint conferences are conducted in the emergency care center, and patient and drug information is shared. A 20-year-old man was transferred to our hospital after a traffic accident. He was diagnosed with subarachnoid hemorrhage and brain contusion. He exhibited violent movement and intense restlessness...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Martin Salinsky, Daniel Storzbach, Elizabeth Goy, Marissa Kellogg, Eilis Boudreau
OBJECTIVES: The long-term outcome of patients with psychogenic nonepileptic seizures (PNES) is of importance given the disabling symptoms and tendency to affect patients early in their productive years. Health care utilization (HCU) is an important outcome measure reflecting overall health status and costs. There is little information regarding long-term HCU following diagnosis of PNES. METHODS: We retrospectively reviewed records of Veterans diagnosed with PNES during epilepsy monitoring unit (EMU) evaluation...
July 2016: Epilepsy & Behavior: E&B
A Bessey, J Chilcott, A Pandor, S Paisley
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Kei Takahashi, Hiroaki Suzuki, Takero Arai, Yasuhisa Okuda
We describe a case of anaphylaxia that occurred in a 67-year-old man. He was planned to have an operation on mitral valve prolapse (MVP) for mitral regurgitation (MR). Morphine 5 mg was injected intramusculaly 45 min before operation. Since then, he felt itchy sensation around his inguinal region. After he came to the operating room, he felt itchy sensation all over the body. Initially, his vatal signs were stable. We started to give extracellular fluid including ulinastatin 300,000 U, methylprednisolone 2 g, and ranitidine 50 mg...
April 2016: Masui. the Japanese Journal of Anesthesiology
Hou-Ji Cao, Qianyi Zhao, Qian-Fan Zhang, Jiaxuan Li, Ewan J M Hamilton, Jie Zhang, Lai-Sheng Wang, Xuenian Chen
Agostic interactions are often used to activate inert C-H bonds, and thus facilitate new reactions. We report the first example of designed catalysts based on the agostic interaction. Novel copper(i) complexes [BBN(pz(x))2]Cu(PPh3)n (BBN = 9-borabicyclo[3.3.1]nonane; pz(x) = 3-substituted pyrazole; x = H, n = 2; x = Me, n = 1) and {[BBN(pz(iPr))2]Cu}2 have been synthesized and characterized. Single crystal studies of the three compounds show weak intramolecular C-HCu interactions which can be assigned as agostic or anagostic interactions...
June 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Madelon den Boeft, Jos W R Twisk, Berend Terluin, Brenda W J H Penninx, Harm W J van Marwijk, Mattijs E Numans, Johannes C van der Wouden, Henriette E van der Horst
BACKGROUND: Medically unexplained physical symptoms (MUPS) are highly prevalent and are associated with frequent health care use (HCU). MUPS frequently co-occur with psychiatric disorders. With this study we examined the longitudinal association between MUPS and HCU over 2 years and the influence of depressive and anxiety disorders and personality traits on this association. METHODS: We analysed follow-up data from 2045 to 2981 participants from the Netherlands Study of Depression and Anxiety (NESDA), a multisite cohort study...
2016: BMC Health Services Research
T Götting, S Klassen, D Jonas, Ch Benk, A Serr, D Wagner, W Ebner
BACKGROUND: Several cases of Mycobacterium chimaera infection have recently been reported in cardiosurgical patients. So-called heater-cooler units (HCUs) used in cardiosurgical procedures are suspected to be the reservoir for pathogen growth and dissemination. AIM: To assess the contamination status of HCUs at our facility. METHODS: Air sampling for mycobacteria was conducted at different distances from the machines and in the area around the operating table...
July 2016: Journal of Hospital Infection
Rami Sommerstein, Christian Rüegg, Philipp Kohler, Guido Bloemberg, Stefan P Kuster, Hugo Sax
Heater-cooler units (HCUs) were recently identified as a source of Mycobacterium chimaera causing surgical site infections. We investigated transmission of this bacterium from HCUs to the surgical field by using a thermic anemometer and particle counter, videotape of an operating room equipped with an ultraclean laminar airflow ventilation system, and bacterial culture sedimentation plates in a nonventilated room. Smoke from the HCU reached the surgical field in 23 s by merging with ultraclean air. The HCU produced on average 5...
June 2016: Emerging Infectious Diseases
Tomas Majtan, Angel L Pey, June Ereño-Orbea, Luis Alfonso Martínez-Cruz, Jan P Kraus
Classical homocystinuria (HCU) is the most common loss-of-function inborn error of sulfur amino acids metabolism. HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine betasynthase (CBS) gene. As with many other inherited disorders, the pathogenic mutations do not target key catalytic residues, but rather introduce structural perturbations leading to an enhanced tendency of the mutant CBS to misfold and either to form non-functional aggregates or to undergo proteasome-dependent degradation...
2016: Current Drug Targets
S Hwang, Z T Nolan, S F White, W C Williams, S Sinclair, R J R Blair
BACKGROUND: To determine the functional integrity of the neural systems involved in emotional responding/regulation and response control/inhibition in youth (age 10-18 years) with disruptive behavioral disorders (DBDs: conduct disorder and/or oppositional defiant disorder) as a function of callous-unemotional (CU) traits. METHOD: Twenty-eight healthy youths and 35 youths with DBD [high CU (HCU), n = 18; low CU (LCU), n = 17] performed the fMRI Affective Stroop task...
May 2016: Psychological Medicine
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