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ultrasonic neuromodulation

Daniel M Ventre, Abigail N Koppes
For the greater part of the last century, ultrasound (US) has seen widespread use in applications ranging from materials science to medicine. The history of US in medicine has also seen promising success in clinical diagnostics and regenerative medicine. Recent studies have shown that US is able to manipulate the nervous system, leading toward potential treatment for various neuropathological conditions, a phenomenon known as ultrasonic neuromodulation (NM). Ultrasonic NM is a promising alternative to pharmaceuticals and surgery, due to high spatiotemporal resolution combined with the potentially noninvasive means of application...
2016: Cells, Tissues, Organs
Jerel K Mueller, Leo Ai, Priya Bansal, Wynn Legon
OBJECTIVE: While ultrasound is largely established for use in diagnostic imaging, its application for neuromodulation is relatively new and crudely understood. The objective of the present study was to investigate the effects of tissue properties and geometry on the wave propagation and heating in the context of transcranial neuromodulation. APPROACH: A computational model of transcranial-focused ultrasound was constructed and validated against empirical data. The models were then incrementally extended to investigate a number of issues related to the use of ultrasound for neuromodulation, including the effect on wave propagation of variations in geometry of skull and gyral anatomy as well as the effect of multiple tissue and media layers, including scalp, skull, CSF, and gray/white matter...
October 2016: Journal of Neural Engineering
Michael Plaksin, Eitan Kimmel, Shy Shoham
Diverse translational and research applications could benefit from the noninvasive ability to reversibly modulate (excite or suppress) CNS activity using ultrasound pulses, however, without clarifying the underlying mechanism, advanced design-based ultrasonic neuromodulation remains elusive. Recently, intramembrane cavitation within the bilayer membrane was proposed to underlie both the biomechanics and the biophysics of acoustic bio-effects, potentially explaining cortical stimulation results through a neuronal intramembrane cavitation excitation (NICE) model...
May 2016: ENeuro
Omer Naor, Steve Krupa, Shy Shoham
Ultrasonic waves can be non-invasively steered and focused into mm-scale regions across the human body and brain, and their application in generating controlled artificial modulation of neuronal activity could therefore potentially have profound implications for neural science and engineering. Ultrasonic neuro-modulation phenomena were experimentally observed and studied for nearly a century, with recent discoveries on direct neural excitation and suppression sparking a new wave of investigations in models ranging from rodents to humans...
June 2016: Journal of Neural Engineering
Ramsis F Ghaly, Tatiana Tverdohleb, Kenneth D Candido, Nebojsa Nick Knezevic
BACKGROUND: Spinal cord stimulation is currently approved to treat chronic intractable pain of the trunk and limbs. However, such implantable electronic devices are vulnerable to external electrical currents and magnetic fields. Within the hospitals and modern operating rooms (ORs), there is an abundance of electrical devices and other types of equipment that could interfere with such devices. Despite the increasing number of patients with neuromodulation implantable devices, there are no written guidelines available or consensus of cautions for such patients undergoing unrelated surgery...
2016: Surgical Neurology International
Taylor J Abel, Timothy Walch, Matthew A Howard
Advances in functional neurosurgery, including neuromodulation and more recently ultrasonic ablation of basal ganglia structures, have improved the quality of life for patients with debilitating movement disorders. What is little known, however, is that both of these neurosurgical advances, which remain on the cutting edge, have their origin in the pioneering work of Russell Meyers, whose contributions are documented in this paper. Meyers' published work and professional correspondence are reviewed, in addition to documents held by the Department of Neurosurgery at the University of Iowa...
February 12, 2016: Journal of Neurosurgery
Sarah M Keesom, Laura M Hurley
Cues from social partners trigger the activation of socially responsive neuromodulatory systems, priming brain regions including sensory systems to process these cues appropriately. The fidelity with which neuromodulators reflect the qualities of ongoing social interactions in sensory regions is unclear. We addressed this issue by using voltammetry to monitor serotonergic fluctuations in an auditory midbrain nucleus, the inferior colliculus (IC), of male mice (Mus musculus) paired with females, and by concurrently measuring behaviors of both social partners...
April 2016: Journal of Neurophysiology
Dongjin Seo, Hao-Yen Tang, Jose M Carmena, Jan M Rabaey, Elad Alon, Bernhard E Boser, Michel M Maharbiz
In this paper, we present an ultrasonic beamforming system capable of interrogating individual implantable sensors via backscatter in a distributed, ultrasound-based recording platform known as Neural Dust [1]. A custom ASIC drives a 7 × 2 PZT transducer array with 3 cycles of 32V square wave with a specific programmable time delay to focus the beam at the 800mm neural dust mote placed 50mm away. The measured acoustic-to-electrical conversion efficiency of the receive mote in water is 0.12% and the overall system delivers 26...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Luciano L Furlanetti, Volker A Coenen, Iñigo A Aranda, Máté D Döbrössy
Preclinical and clinical evidence suggests that depression might be associated with a dysfunction in the reward/motivation circuitry. Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has been shown in a recent clinical trial to provide a prompt and consistent improvement of depressive symptoms in treatment-resistant patients. In order to better understand the underlying mechanisms of neuromodulation in the context of depression, the effects of chronic bilateral MFB-DBS were assessed in a combined rodent model of depression and Parkinson's disease...
November 2015: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Tengfei Guo, Hangdao Li, Yifan Lv, Hongyang Lu, Jinhai Niu, Junfeng Sun, Guo-Yuan Yang, Chuancheng Ren, Shanbao Tong
GOAL: We applied a low-intensity pulsed transcranial ultrasound stimulation (pTUS) to the ischemic cortex after a distal middle cerebral artery occlusion (dMCAO) to study whether pTUS is capable of protecting brain from ischemic injury. METHODS: Rats were randomly assigned to Sham (n = 6), Control (n = 16), and pTUS (n = 16) groups. The pTUS-treated rats were subjected to 60-min ultrasonic stimulation immediately after the ischemia. After 48 h, the sensorimotor-related behavioral outcomes were assessed by a neurological severity score (NSS), and the permanent brain injury was assessed by the histologic analysis of TTC staining of brain slices...
October 2015: IEEE Transactions on Bio-medical Engineering
Jerel Mueller, Wynn Legon, Alexander Opitz, Tomokazu F Sato, William J Tyler
BACKGROUND: The integration of EEG recordings and transcranial neuromodulation has provided a useful construct for noninvasively investigating the modification of human brain circuit activity. Recent evidence has demonstrated that focused ultrasound can be targeted through the human skull to affect the amplitude of somatosensory evoked potentials and its associated spectral content. OBJECTIVE/HYPOTHESIS: The present study tests whether focused ultrasound transmitted through the human skull and targeted to somatosensory cortex can affect the phase and phase rate of cortical oscillatory dynamics...
November 2014: Brain Stimulation
Eduardo J Juan, Rafael González, Gabriel Albors, Matthew P Ward, Pedro Irazoqui
The use of focused ultrasonic waves to modulate neural structures has gained recent interest due to its potential in treating neurological disorders non-invasively. While several papers have focused on the use of ultrasound neuromodulation on peripheral nerves, none of these studies have been performed on the vagus nerve. We present preliminary observations on the effects of focused pulsed ultrasound (FPUS) on the conduction of the left cervical vagus nerve of a Long Evans rat. Ultrasound energy was applied at a frequency of 1...
March 1, 2014: International Journal of Imaging Systems and Technology
Mark Nowell, Anna Miserocchi, Andrew W McEvoy, John S Duncan
This review summarises exciting recent and forthcoming advances that will impact on the surgical management of epilepsy in the near future. This does not cover the current accepted diagnostic methodologies or surgical treatments that are routinely practiced today. The content of this review was derived from a PubMed literature search, using the key words 'Epilepsy Surgery', 'Neuromodulation', 'Neuroablation', 'Advances', between 2010 and November 2013.
November 2014: Journal of Neurology, Neurosurgery, and Psychiatry
Edin Mehić, Julia M Xu, Connor J Caler, Nathaniel K Coulson, Chet T Moritz, Pierre D Mourad
Transcranial ultrasound can alter brain function transiently and nondestructively, offering a new tool to study brain function now and inform future therapies. Previous research on neuromodulation implemented pulsed low-frequency (250-700 kHz) ultrasound with spatial peak temporal average intensities (ISPTA) of 0.1-10 W/cm(2). That work used transducers that either insonified relatively large volumes of mouse brain (several mL) with relatively low-frequency ultrasound and produced bilateral motor responses, or relatively small volumes of brain (on the order of 0...
2014: PloS One
Rob Dallapiazza, M Sean McKisic, Binit Shah, W Jeff Elias
Surgical neuromodulation has emerged as the primary method to treat the medically refractory symptoms of essential tremor and Parkinson disease. With reversible manipulation of CNS neurons, neuromodulation can be used to intraoperatively localize and verify a stereotactic target, and to chronically treat movement disorders. This article discusses the historical advances in stereotactic surgery using various modalities of neuromodulation leading to contemporary treatment. Electrical neuromodulation, or deep brain stimulation, is emphasized as the major surgical intervention with a discussion of the technique, surgical targets, and clinical outcomes...
January 2014: Neurosurgery Clinics of North America
Mohamed K Metwally, Hee-Sok Han, Hyun Jae Jeon, Gon Khang, Tae-Seong Kim
Lately, neuromodulation of the brain is considered one of the promising applications of ultrasound technology in which low-intensity focused ultrasound (LIFU) is used noninvasively to excite or inhibit neuronal activity. In LIFU, one of critical barriers in the propagation of ultrasound wave is the skull, which is known to be highly anisotropic mechanically: this affects the ultrasound focusing, thereby neuromodulation effects. This study aims to investigate the influence of the anisotropic properties of the skull on the LIFU via finite element head models incorporating the anisotropic properties of the skull...
2013: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Guangchen Ji, Yu Fu, Hita Adwanikar, Volker Neugebauer
BACKGROUND: Corticotropin-releasing factor (CRF) plays an important role in affective states and disorders. CRF is not only a "stress hormone" but also a neuromodulator outside the hypothalamic-pituitary-adrenocortical (HPA) axis. The amygdala, a brain center for emotions, is a major site of extrahypothalamic expression of CRF and its G-protein-coupled receptors. Our previous studies showed that endogenous activation of CRF1 receptors in an arthritis pain model contributes to amygdala hyperactivity and pain-related behaviors...
2013: Molecular Pain
Karen L Smith, Gemma K Ford, David S Jessop, David P Finn
The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the neurobiological mechanisms underlying harmane's psychotropic effects are poorly understood. We investigated the effects of intraperitoneal injection of harmane (2.5 and 10 mg/kg) on fear-conditioned behaviour, hypothalamo-pituitary-adrenal axis activity, and monoaminergic activity within specific fear-associated areas of the rat brain...
February 2013: Journal of Psychopharmacology
Amit P Mulgaonkar, Rahul S Singh, Meghedi Babakhanian, Martin O Culjat, Warren S Grundfest, Alessandra Gorgulho, Goran Lacan, Antonio A F De Salles, Alexander Bystritsky, William P Melega
A prototype Low Intensity Focused Ultrasound (LIFU) stimulator system was developed to evaluate non-invasive neuromodulation in a large animal model. We conducted a feasibility study on a Göttingen minipig, demonstrating reversible, targeted transcranial neuromodulation. The hypothalamus of the minipig was repeatedly stimulated with LIFU which evoked temporally correlated increases in both heart rate and blood pressure.
2012: Studies in Health Technology and Informatics
Yusuf Tufail, Anna Yoshihiro, Sandipan Pati, Monica M Li, William J Tyler
Brain stimulation methods are indispensable to the study of brain function. They have also proven effective for treating some neurological disorders. Historically used for medical imaging, ultrasound (US) has recently been shown to be capable of noninvasively stimulating brain activity. Here we provide a general protocol for the stimulation of intact mouse brain circuits using transcranial US, and, using a traditional mouse model of epilepsy, we describe how to use transcranial US to disrupt electrographic seizure activity...
September 2011: Nature Protocols
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