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Ultrafiltration

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https://www.readbyqxmd.com/read/29049308/the-relationship-between-intradialytic-hypotension-and-vascular-calcification-in-hemodialysis-patients
#1
AJin Cho, Young-Ki Lee, Jieun Oh, Jong-Woo Yoon, Dong Ho Shin, Hee Jung Jeon, Myung-Jin Choi, Jung-Woo Noh
BACKGROUND: Vascular calcification is associated with structural and functional abnormality of the heart and blood vessels. We investigated the relationship between intradialytic hypotension (IDH) and vascular calcification in hemodialysis (HD) patients, and their impacts on cardiovascular events (CVEs). METHOD: We enrolled 191 maintenance HD patients who underwent plain abdomen radiography for abdominal aortic calcification score (AACS). A nadir systolic blood pressure (BP) < 90 mm Hg or the requirement of bolus fluid administration was required to quantify the hypotension diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/29042837/vancomycin-dosing-in-pediatric-extracorporeal-membrane-oxygenation-potential-impacts-of-new-technologies
#2
Kevin P Lonabaugh, Kelly J Lunsford, Gary Y Fang, David A Kaufman, Samuel D Addison, Marcia L Buck
OBJECTIVES: The objective of the current study was to evaluate the doses of vancomycin used to obtain therapeutic drug concentrations in pediatric patients on extracorporeal membrane oxygenation (ECMO), using new ECMO technologies. METHODS: This was a single-center, retrospective study of patients treated with vancomycin while receiving ECMO using low-volume circuit technology. RESULTS: A total of 28 patients were included in the analysis of the primary endpoint...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29039106/improved-ultrafiltration-method-to-measure-drug-release-from-nanomedicines-utilizing-a-stable-isotope-tracer
#3
Sarah L Skoczen, Stephan T Stern
An important step in the early development of a nanomedicine formulation is the evaluation of stability and drug release in biological matrices. Additionally, the measurement of encapsulated and unencapsulated nanomedicine drug fractions is important for the determination of bioequivalence (pharmacokinetic equivalence) of generic nanomedicines. Unfortunately, current methods to measure drug release in plasma are limited, and all have fundamental disadvantages including non-equilibrium conditions and process-induced artifacts...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29037914/antimicrobial-activity-and-preliminary-mode-of-action-of-plnef-expressed-in-escherichia-coli-against-staphylococci
#4
Xuan Tang, Shuangshuang Wu, Xiaofeng Wang, Qing Gu, Ping Li
Strains belonging to the genus of Staphylococci, such as Staphylococcus aureus are common pathologic bacteria which may cause nosocomial cross infection and food contamination. Plantaricin EF (PlnEF), a two-peptide nonlantibiotic bacteriocin produced by Lactobacillus plantarum strains, shows great inhibitory effects against Gram-positive Staphylococci strains. To overproduce this two-peptide bacteriocin, plnE and plnF genes were cloned into pET32a (+) vector and heterologously expressed in Escherichia coli by fusion with His6-tag in this study...
October 13, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/29037738/peptides-derived-from-in-vitro-gastrointestinal-digestion-of-germinated-soybean-proteins-inhibit-human-colon-cancer-cells-proliferation-and-inflammation
#5
Marcela González-Montoya, Blanca Hernández-Ledesma, Jose Manuel Silván, Rosalva Mora-Escobedo, Cristina Martínez-Villaluenga
The aim was to investigate the potential of germinated soybean proteins asa source of peptides with anticancer and anti-inflammatory activities produced after simulated gastrointestinal digestion. Protein concentrate from germinated soybean was hydrolysed with pepsin/pancreatin and fractionated by ultrafiltration. Whole digest and fractions>10, 5-10, and<5kDa caused cytotoxicity to Caco-2, HT-29, HCT-116 human colon cancer cells, and reduced inflammatory response caused by lipopolysaccharide in macrophages RAW 264...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29037728/structural-polymeric-features-that-contribute-to-in-vitro-immunostimulatory-activity-of-instant-coffee
#6
Sónia S Ferreira, Cláudia P Passos, Márcio R Cepeda, Guido R Lopes, Maria Teixeira-Coelho, Pedro Madureira, Fernando M Nunes, Manuel Vilanova, Manuel A Coimbra
An instant coffee fraction, rich in arabinogalactans, obtained by ultrafiltration, using 1 and 5kDa membranes, has previously shown in vitro stimulatory activity on BALB/c mice spleen B lymphocytes. The compounds inducing lymphocytic activation were shown to elute, mainly near the void volume by size-exclusion chromatography, using Bio-Gel P6 (1-6kDa). Treatment of the compounds with chymotrypsin, a digestive protease, did not affect the induced B lymphocyte activation. On the contrary, hydrolysis with an α-l-arabinofuranosidase, removing single terminally-linked arabinose residues, decreased the extent of B cell activation...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29037688/production-of-phytotherapeutics-from-broccoli-juice-by-integrated-membrane-processes
#7
Emel Yilmaz, Pelin Onsekizoglu Bagci
An integrated membrane process for the recovery and concentration of phytotherapeutics in broccoli juice was investigated to develop a natural product that could be of interest for food and/or pharmaceutical industry. Following a pretreatment step to remove suspended solids, the juice was ultrafiltered through a 50kDa MWCO polyethersulfone membrane. The permeate stream was further concentrated by osmotic distillation up to 42.6°Brix. During ultrafiltration, a complete recovery of sulforaphane, malic acid and citric acid was achieved, where total phenolic content and ascorbic acid were recovered at a ratio of 94...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29034640/-preparation-and-antioxidant-activity-detection-of-collagen-peptide-from-cirrhinus-molitorella-skin
#8
Cuiling Wu, Ribang Wu, Dan Liu, Xinghao Yang, Jiang Zhang, Jiafeng Huang, Hailun He
In order to prepare antioxidant peptide through hydrolyzing low-value protein resources with bacterial extracellular proteases and to discover novel proteases, crude extracellular protease from Pseudoalteromonas sp. SHK1-2 was obtained through fermentation which was used to hydrolyze collagen extracted from Cirrhinus molitorella skin. Small peptide fraction was isolated from hydrolysate by ultrafiltration and Sephadex LH-20 size exclusion chromatography and showed 1, 1-diphenyl-2-picrylhydrazyl radical scavenging activity (35...
December 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29030229/elevation-of-proenkephalin-143-183-in-cerebrospinal-fluid-in-moyamoya-disease
#9
Kinya Yokoyama, Mikio Maruwaka, Kazuhiro Yoshikawa, Yoshio Araki, Sho Okamoto, Masaki Sumitomo, Akino Kawamura, Yusuke Sakamoto, Kenzo Shimizu, Takashi Izumi, Toshihiko Wakabayashi
BACKGROUND: In moyamoya disease (MMD), the causes of differences in clinical features between children and adults and of the dramatic temporal changes in moyamoya vessels are poorly understood. We previously discovered elevated levels of m/z 4588 and m/z 4473 peptides in cerebrospinal fluid (CSF) in MMD patients. This study examined the amino acid sequences of these peptides and quantified in specimens. METHODS: The m/z 4588 and m/z 4473 peptides in CSF from MMD patients were purified and concentrated by high-performance liquid chromatography and ultrafiltration...
October 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29028574/gravity-directed-separation-of-both-immiscible-and-emulsified-oil-water-mixtures-utilizing-coconut-shell-layer
#10
Jian Li, Changcheng Xu, Yan Zhang, Xiaohua Tang, Wei Qi, Qiong Wang
Pressure-driven and lower flux of superwetting ultrafiltration membranes in various emulsions separation are long-standing issues and major barriers for their large-scale utilization. Even though currently reported membranes have achieved great success in emulsions separeation, they still suffer from low flux and complex fabrication process resulting from their smaller nanoscale pore size. Herein, utilizition of coconut shell as a novel biomaterial for developing into a layer through the simple smashing, cleaning and stacking procedures, which not only could avoid the complexity of film making process, but also could realize efficient gravity-directed separation of both immiscible oil/water mixtures and water-in-oil emulsions with high flux...
September 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028405/evaluation-of-plasma-peptides-extraction-methods-by-high-resolution-mass-spectrometry
#11
N V Zakharova, A Y Shornikova, A E Bugrova, V V Baybakova, M I Indeykina, A S Kononikhin, I A Popov, O I Kechko, A A Makarov, E N Nikolaev
Monitoring of peptides offers a promising approach for the discovery of novel biomarkers, which might be valuable for detection, treatment and prevention of large variety of diseases. Development of highly effective methods for plasma peptide extraction remains an important task. In the current study, we applied different types of plasma peptide extraction approaches to reveal efficient methods which would provide the highest peptide yield. We used different combinations of plasma treatment with acetonitrile and/or urea/guanidine, protein precipitation by acetone, gel-filtration, ultrafiltration, and two types of solid phase extraction...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29027934/angiotensin-i-converting-enzyme-ace-inhibitory-activity-antioxidant-properties-phenolic-content-and-amino-acid-profiles-of-fucus-spiralis-l-protein-hydrolysate-fractions
#12
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1-3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase-bromelain...
October 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29025543/pericardial-effusion
#13
REVIEW
Amir Azarbal, Martin M LeWinter
The normal pericardial sac contains up to 50 mL of fluid, which consists of a plasma ultrafiltrate. Anything greater constitutes a pathologic effusion. The curvilinear pressure-volume relationship of the pericardial sac dictates hemodynamic consequences of a pericardial effusion and is responsible for rapidly accumulating fluid that causes cardiac tamponade. A variety of diseases and complications cause pericardial effusion. The most common are idiopathic pericarditis, cancer, connective tissue disorders, and hemorrhage...
November 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/29024379/can-a-renal-nurse-assess-fluid-status-using-ultrasound-on-the-inferior-vena-cava-a-cross-sectional-interrater-study
#14
Ulrich Steinwandel, Nicholas Gibson, Amanda Towell, James J R Rippey, Johan Rosman
INTRODUCTION: Ultrasound of the inferior vena cava (IVC-US) has been used to estimate intravascular volume status and fluid removal during a hemodialysis session. Usually, renal nurses rely on other, imprecise methods to determine ultrafiltration. To date, no study has examined whether renal nurses can reliably perform ultrasound for volume assessment and for potential prevention of intradialytic hypotension. This pilot study aimed to determine if a renal nurse could master the skill of performing and correctly interpreting Point of Care Ultrasound on patients receiving hemodialysis...
October 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29018100/randomized-crossover-trial-of-blood-volume-monitoring-guided-ultrafiltration-biofeedback-to-reduce-intradialytic-hypotensive-episodes-with-hemodialysis
#15
Kelvin C W Leung, Robert R Quinn, Pietro Ravani, Henry Duff, Jennifer M MacRae
BACKGROUND AND OBJECTIVES: Intradialytic hypotension (IDH) is associated with morbidity. The effect of blood volume-guided ultrafiltration biofeedback, which automatically adjusts fluid removal rate on the basis of blood volume parameters, on the reduction of IDH was tested in a randomized crossover trial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a 22-week, single blind, randomized crossover trial in patients receiving maintenance hemodialysis who had >30% of sessions complicated by symptomatic IDH in five centers in Calgary, Alberta, Canada...
October 10, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29017146/fouling-behavior-of-poly-ether-sulfone-ultrafiltration-membrane-during-concentration-of-whey-proteins-effect-of-hydrophilic-modification-using-atmospheric-pressure-argon-jet-plasma
#16
Irem Damar Huner, Haci Ali Gulec
The aim of the study was to investigate the effects of hydrophilic surface modification via atmospheric pressure jet plasma (ApJPls) on the fouling propensity of polyethersulfone (PES) ultrafiltration (UF) membranes during concentration of whey proteins. The distance from nozzle to substrate surface of 30mm and the exposure period of 5 times were determined as the most effective parameters enabling an increase in ΔGiwi value of the plain membrane from (-) 14.92±0.89mJ/m(2) to (+) 17.57±0.67mJ/m(2). Maximum hydrophilicity and minimum surface roughness achieved by argon plasma action resulted in better antifouling behavior, while the hydraulic permeability and the initial permeate flux were decreased sharply due to the plasma-induced surface cross-linking...
October 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29017134/variations-in-size-and-composition-of-colloidal-organic-matter-in-a-negative-freshwater-estuary
#17
Huacheng Xu, Erin M Houghton, Christopher J Houghton, Laodong Guo
Dynamic variations in chemical composition and size distribution of dissolved organic matter (DOM) along the river-lake interface in the Fox River plume were investigated using ultrafiltration, flow field-flow fractionation, UV-Vis and fluorescence spectroscopy and parallel factor analysis. On average, ~67% of bulk dissolved organic carbon (DOC) were partitioned in the <1kDa (actual cutoff 2.5kDa) low molecular weight fraction, and the other 33% were in the 1kDa-0.7μm colloidal phase. Concentrations of DOC and chromophoric DOM in the bulk and size-fractionated samples decreased monotonously with decreasing conductivity from river to bay waters, demonstrating a dominant terrestrial source and quasi conservative mixing behavior...
October 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28991803/enhanced-flux-performance-of-polyamide-composite-membranes-prepared-via-interfacial-polymerization-assisted-with-ethyl-formate
#18
Zhaofeng Liu, Guiru Zhu, Yulin Wei, Dapeng Zhang, Lei Jiang, Haizeng Wang, Congjie Gao
A novel thin film composite (TFC) polyamide reverse osmosis membrane was prepared via the interfacial polymerization of m-phenylene diamine (MPD) in aqueous phase and 1,3,5-trimesoyl chloride (TMC) in organic phase on a polysulfone ultrafiltration support by assisting with ethyl formate as a co-solvent added in the organic phase. The ethyl formate added in the organic phase is intended to form a narrow miscibility zone, which leads to the thicker reaction zone. The multi-layered loose polyamide structure with larger pore size was formed due to the thicker reaction zone and lower content of MPD...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28991794/microbiological-and-physicochemical-evaluation-of-the-effluent-quality-in-a-membrane-bioreactor-system-to-meet-the-legislative-limits-for-wastewater-reuse
#19
Konstantinos Azis, Charalampos Vardalachakis, Spyridon Ntougias, Paraschos Melidis
The aim of this study was to assess the efficacy and effluent quality of a pilot-scale intermittently aerated and fed, externally submerged membrane bioreactor (MBRes) treating municipal wastewater. The effluent quality of the MBRes was evaluated regarding system ability to comply with the Greek legislative limits for restricted and unrestricted wastewater reuse. The average permeate flux was 13.9 L m(-2) h(-1), while the transmembrane pressure remained above the level of -110 mbar. Experimental data showed that biochemical oxygen demand, chemical oxygen demand, total nitrogen, PO4(3-)- P and total suspended solids removal efficiencies were 97...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28989744/mixed-matrix-membranes-with-enhanced-antifouling-activity-probing-the-surface-tailoring-potential-of-tiron-and-chromotropic-acid-for-nano-tio2
#20
Avishek Pal, T K Dey, A K Debnath, Bharat Bhushan, A K Sahu, R C Bindal, Soumitra Kar
Mixed-matrix membranes (MMMs) were developed by impregnating organofunctionalized nanoadditives within fouling-susceptible polysulfone matrix following the non-solvent induced phase separation (NIPS) method. The facile functionalization of nanoparticles of anatase TiO2 (nano-TiO2) by using two different organoligands, viz. Tiron and chromotropic acid, was carried out to obtain organofunctionalized nanoadditives, FT-nano-TiO2 and FC-nano-TiO2, respectively. The structural features of nanoadditives were evaluated by X-ray diffraction, X-ray photoelectron spectroscopy, Raman and Fourier transform infrared spectroscopy, which established that Tiron leads to the blending of chelating and bridging bidentate geometries for FT-nano-TiO2, whereas chromotropic acid produces bridging bidentate as well as monodentate geometries for FC-nano-TiO2...
September 2017: Royal Society Open Science
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