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https://www.readbyqxmd.com/read/29042985/long-noncoding-rna-eosinophil-granule-ontogeny-transcript-inhibits-cell-proliferation-and-migration-and-promotes-cell-apoptosis-in-human-glioma
#1
You Wu, Shunli Liang, Bin Xu, Rongbo Zhang, Minzi Zhu, Weiying Zhou, Shuijing Zhang, Jinhui Guo, Linsheng Xu, Hongye Zhu
Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. Recent advances have implicated long noncoding RNAs (lncRNAs) as crucial mediators of cancer development and progression. The present study aimed to investigate the role of a newly-discovered lncRNA, termed eosinophil granule ontogeny transcript (EGOT), in the aggressive abilities of cells in human glioma. It was initially found that the relative transcription level of EGOT in glioma cancerous tissues was significantly lower than that in adjacent non-cancerous tissues...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29035824/knockdown-of-diaph1-expression-inhibits-migration-and-decreases-the-expression-of-mmp2-and-mmp9-in-human-glioma-cells
#2
Can Zhang, Lin Wang, Jiaying Chen, Jie Liang, Yaming Xu, Zhe Li, Fuxue Chen, Dongshu Du
As the most common primary central nervous system tumor, glioma is characterized by high levels of mortality and migration. Unclear boundary with normal brain tissue results in poor treatment. The mammalian diaphanous-related formin 1 (Diaph1) which belongs to formin-homology protein family, is a target of RhoA and involved in a number of actin-related biological processes, which abnormally expressed in pathological conditions in a number of tumors. Immunohistochemical analysis showed that Diaph1 was overexpressed in glioma tissues compared with normal human brain tissue...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29029454/long-noncoding-rna-ab073614-promotes-the-malignance-of-glioma-by-activating-wnt-%C3%AE-catenin-signaling-through-downregulating-sox7
#3
Yuqian Li, Gang Zhu, Wen Zeng, Jiancai Wang, Zhihong Li, Bao Wang, Bo Tian, Dan Lu, Xingye Zhang, Guodong Gao, Lihong Li
Long noncoding RNA (lncRNA) AB073614 has recently shown to be aberrantly increased and identified as a poor prognostic biomarker in human glioma. However, the potential mechanisms remain unknown. This study demonstrated that AB073614 expression was significantly upregulated in both glioma tissues and cell lines, and glioma patients with high AB073614 expression had lower overall survival rates. Importantly, silencing AB073614 expression remarkably inhibited U251 cell proliferation, migration, and invasion in vitro, as well as suppressed tumor formation in vivo...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029445/microrna-200c-increases-radiosensitivity-of-human-cancer-cells-with-activated-egfr-associated-signaling
#4
Taeryool Koo, Bong Jun Cho, Dan Hyo Kim, Ji Min Park, Eun Jung Choi, Hans H Kim, David J Lee, In Ah Kim
MicroRNA-200c (miR-200c) recently was found to have tumor-suppressive properties by inhibiting the epithelial-mesenchymal transition (EMT) in several cancers. miR-200c also interacts with various cellular signaling molecules and regulates many important signaling pathways. In this study, we investigated the radiosensitizing effect of miR-200c and its mechanism in a panel of human cancer cell lines. Malignant glioma (U251, T98G), breast cancer (MDA-MB-468), and lung carcinoma (A549) cells were transfected with control pre-microRNA, pre-miR-200c, or anti-miR-200c...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29024917/thermo-responsive-mesoporous-silica-lipid-bilayer-hybrid-nanoparticles-for-doxorubicin-on-demand-delivery-and-reduced-premature-release
#5
Qing Zhang, Xuanxuan Chen, Huihui Shi, Gaoqiu Dong, Meiling Zhou, Tianji Wang, Hongliang Xin
Hybrid nanocarriers based on mesoporous silica nanoparticles (MSNs) and supported lipid bilayer (SLB) have been studied as drug delivery system. It still remains challenges to develop these nanocarriers (SLB-MSNs) with on-demand drug release profile for chemotherapy. Here, we reported the biocompatible SLB-MSNs with high drug loading, which could release doxorubicin (DOX) in response to hyperthermia and reduce premature release. After synthesis of MSNs via a sol-gel procedure, the thermo-responsive SLB was deposited on the MSNs by sonication to completely seal the mesopores...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29024247/cacybp-sip-inhibits-the-migration-and-invasion-behaviors-of-glioblastoma-cells-through-activating-siah1-mediated-ubiquitination-and-degradation-of-cytoplasmic-p27
#6
Shiwei Yan, Aimin Li, Yuguang Liu
Calcyclin-binding protein or Siah-1-interacting protein (CacyBP/SIP) has been reported to be up-regulated and plays an important role in promoting cell proliferation in human glioma. However, the effect of CacyBP/SIP on glioma cell motility is still unclear. Here, to our surprise, CacyBP/SIP was found to inhibit the migration and invasion of glioma cells U251 and U87. Silencing of CacyBP/SIP significantly the promoted the migration and invasion behaviors of glioma cells. On the contrary, Overexpression of CacyBP/SIP obviously suppressed them...
October 10, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28987792/cordycepin-induces-apoptotic-cell-death-of-human-brain-cancer-through-the-modulation-of-autophagy
#7
Nipha Chaicharoenaudomrung, Thiranut Jaroonwitchawan, Parinya Noisa
Brain cancer, in particular neuroblastoma and glioblastoma, is a global challenge to human health. Cordycepin, extracted from Cordyceps ssp., has been revealed as a strong anticancer agent through several ways; however, the mechanism, by which cordycepin counteracts brain cancers, is still poorly understood. In this study, the underlying mechanisms of cordycepin against human brain cancer cells were explored. SH-SY5Y and U251 cells were being a model to represent human neuroblastoma and glioblastoma, respectively...
October 4, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28983584/na-k-%C3%A2-atpase-dr-region%C3%A2-specific-antibody-protects-u251-cells-against-hypoxia-reperfusion%C3%A2-induced-injury-via-the-pi3k-akt-and-erk-pathways
#8
Huilin Gong, Pengbiao Lü, Jiangwei Zhang, Dandong Li, Jin Zheng, Jinning Song
Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. This leads to poor oxygen supply or cerebral hypoxia and to the death of brain tissue or cerebral infarction/ischemic stroke. In the present study, an Na+/K+‑ATPase (NKA) DR region‑specific antibody (DRSAb) was established and purified and it was demonstrated that DRSAb induced a protective effect on human astrocytes (U251) via the phosphoinositide 3‑kinase (PI3K)/AKT and extracellular signal‑regulated protein kinase (ERK) signaling pathways...
September 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28979815/whole-exome-wide-association-study-identifies-a-missense-variant-in-slc2a4rg-associated-with-glioblastoma-risk
#9
Yingjie Zhao, Dapeng Yun, Xiang Zou, Tao Jiang, Gang Li, Lingna Hu, Juxiang Chen, Jianfeng Xu, Ying Mao, Hongyan Chen, Daru Lu
In this study, we conducted a genome-wide scan of single nucleotide polymorphisms (SNPs) to identify coding variants that is associated with the risk of glioblastoma (GBM), the most common and most malignant subtype of glioma. We genotyped 1038 GBM cases and 1008 controls in a Chinese Han population using Illumina HumanExome Beadchip v1.0. A missense variant, rs8957 (E[GAG]233D[GAU], SLC2A4RG, 20q13.33), was found being associated with GBM risk, with an odd ratio (OR) of 1.43 (95% confidence interval (CI) = 1...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28978117/a-regulatory-role-for-the-co-chaperone-fkbp51s-in-pd-l1-expression-in-glioma
#10
Paolo D'Arrigo, Michele Russo, Anna Rea, Martina Tufano, Elia Guadagno, Maria Laura Del Basso De Caro, Roberto Pacelli, Felix Hausch, Stefania Staibano, Gennaro Ilardi, Silvia Parisi, Maria Fiammetta Romano, Simona Romano
BACKGROUND: FKBP51 is a co-chaperone with isomerase activity, abundantly expressed in glioma. We previously identified a spliced isoform (FKBP51s) and highlighted a role for this protein in the upregulation of Programmed Death Ligand 1 (PD-L1) expression in melanoma. Because gliomas can express PD-L1 causing a defective host anti-tumoral immunity, we investigated whether FKBP51s was expressed in glioma and played a role in PD-L1 regulation in this tumour. METHODS: We used D54 and U251 glioblastoma cell lines that constitutively expressed PD-L1...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974241/recombinant-newcastle-disease-virus-rl-rvg-enhances-the-apoptosis-and-inhibits-the-migration-of-a549-lung-adenocarcinoma-cells-via-regulating-alpha-7-nicotinic-acetylcholine-receptors-in-vitro
#11
Yulan Yan, Chunxiang Su, Min Hang, Hua Huang, Yinghai Zhao, Xiaomei Shao, Xuefeng Bu
BACKGROUND: The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation of alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) and to analyze the relationships between α7 nAChR expression in lung cancer and the clinical pathological features. METHODS: α7 nAChR expression in A549, LΑ795, and small-cell lung carcinoma (SCLC) cells, among others, was detected using reverse transcription polymerase chain reaction (RT-PCR)...
October 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/28969635/impact-of-mesenchymal-stem-cells-secretome-on-glioblastoma-pathophysiology
#12
Joana Vieira de Castro, Eduardo D Gomes, Sara Granja, Sandra I Anjo, Fátima Baltazar, Bruno Manadas, António J Salgado, Bruno M Costa
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells (MSCs), either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic capacity to migrate towards malignant tumors. Nevertheless, it is still controversial whether this innate tropism of MSCs towards the tumor area is associated with cancer promotion or suppression...
October 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28947502/restricted-delivery-of-talazoparib-across-the-blood-brain-barrier-limits-the-sensitizing-effects-of-poly-adp-ribose-polymerase-inhibition-on-temozolomide-therapy-in-glioblastoma
#13
Sani H Kizilbash, Shiv K Gupta, Kenneth Chang, Ryo Kawashima, Karen E Parrish, Brett L Carlson, Katrina K Bakken, Ann C Mladek, Mark A Schroeder, Paul A Decker, Gaspar J Kitange, Yuqiao Shen, Ying Feng, Andrew A Protter, William F Elmquist, Jann N Sarkaria
Poly (ADP-ribose) polymerase PARP inhibitors, including talazoparib (TAL), potentiate temozolomide (TMZ) efficacy in multiple tumor types, however TAL-mediated sensitization has not been evaluated in orthotopic glioblastoma (GBM) models. This study evaluates TAL ± TMZ in clinically relevant GBM models. TAL at 1-3 nmol/L sensitized T98G, U251 and GBM12 cells to TMZ, and enhanced DNA damage signaling and G2/M arrest in vitro. In vivo cyclical therapy with TAL (0.15 mg/kg twice daily) combined with low dose TMZ (5 mg/kg daily) was well tolerated...
September 25, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28943937/knockdown-of-sall4-expression-using-rna-interference-induces-cell-cycle-arrest-enhances-early-apoptosis-inhibits-invasion-and-increases-chemosensitivity-to-temozolomide-in-u251-glioma-cells
#14
Lei Zhang, Yong Yan, Ying Jiang, Jun Qian, Lei Jiang, Guohan Hu, Yicheng Lu, Chun Luo
Spalt-like transcription factor 4 (SALL4) is essential for the maintenance of the self-renewal and pluripotent properties in embryonic stem cells. Although the detailed mechanism remains unclear, dysregulation of SALL4 has been detected in various malignancies. Previously, the authors' of the present study reported that the expression level of SALL4 was associated with the poor prognosis of glioblastoma multiforme (GBM). The present study aimed to investigate the function of SALL4 in U251 human glioblastoma cells, including apoptosis and invasion inhibition...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943909/downregulation-of-lrig2-expression-inhibits-angiogenesis-of-glioma-via-egfr-vegf-a-pathway
#15
Hong-Kuan Yang, Hao Chen, Feng Mao, Qun-Gen Xiao, Rui-Fan Xie, Ting Lei
Active angiogenesis is the basic pathological feature of glioma. Tumor angiogenesis is involved in vascular endothelial cell migration to the tumor tissue and in the formation of tube-like structures. The present study aimed to investigate the role of leucine-rich repeats and immunoglobulin-like domains 2 (LRIG2) in glioma angiogenesis. Glioma (n=50) and normal brain (n=20) tissue samples were collected from patients to detect the expression of LRIG2, epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGF-A), and cluster of differentiation 31 (CD31) using immunohistochemistry...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28939749/cd90-expression-controls-migration-and-predicts-dasatinib-response-in-glioblastoma
#16
Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R Colen, Brett L Carlson, Paul A Decker, Jann N Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien
PURPOSE: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells including glioblastoma (GBM) stem cells (GSCs). However, the molecular and cellular functions of CD90 remain unclear. EXPERIMENTAL DESIGN: The function of CD90 in GBM was addressed using cellular models from immortalized and primary GBM lines, in vivo orthotopic mouse models, GBM specimens' transcriptome associated with MRI features from GBM patients...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28934982/mir-320-inhibits-the-growth-of-glioma-cells-through-downregulating-pbx3
#17
Cuicui Pan, Hua Gao, Ni Zheng, Qi Gao, Yuanquan Si, Yueran Zhao
BACKGROUND: MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been reported to be upregulated in various tumors and promote tumor cell growth through regulating MAKP/ERK pathway. This study aimed to verify whether miR-320 influences glioma cells growth through regulating PBX3. METHODS: Twenty-four human glioma and paired adjacent nontumorous tissues were collected for determination of miR-320 and PBX3 expression using RT-qPCR and western blot assays...
September 21, 2017: Biological Research
https://www.readbyqxmd.com/read/28928883/ahnak-as-a-prognosis-factor-suppresses-the-tumor-progression-in-glioma
#18
Zijin Zhao, Songhua Xiao, Xianrui Yuan, Jian Yuan, Chi Zhang, Haoyu Li, Jun Su, Xiangyu Wang, Qing Liu
PURPOSE: AHNAK is originally identified as a giant protein based on the estimated size of approximately 700 kDa. The aim of this study is to identify the role of AHNAK in the pathogenesis of glioma. METHODS: We tested AHNAK mRNA level in a panel of six human glioma cell lines, and in 30 cases of normal brain tissues and 73 cases of glioma tissue samples using a qRT-PCR method. Further, we analyzed the relationship of AHNAK expression with clinicopathological characteristics in glioma patients...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928851/%C3%AE-transducin-repeat-containing-e3-ubiquitin-protein-ligase-inhibits-migration-invasion-and-proliferation-of-glioma-cells
#19
Jun Liang, Wei-Feng Wang, Shao Xie, Xian-Li Zhang, Wei-Feng Qi, Xiu-Ping Zhou, Jin-Xia Hu, Qiong Shi, Ru-Tong Yu
β-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP) serves as the substrate recognition subunit for the Skp1-Cullin1-F-box protein E3 ubiquitin ligase, which recognizes the double phosphorylated DSG (X)2+nS destruction motif in various substrates that are essential for numerous aspects of tumorigenesis and regulates several important signaling pathways. However, the biological significance of β-TrCP in glioma progression remains largely unknown. A previous study by the authors demonstrated that the levels of β-TrCP protein expression in brain glioma tissues were significantly lower compared with non-tumorous tissues and that higher grades of gliomas exhibited lower levels of β-TrCP expression in comparison with lower glioma grades...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927156/activation-of-%C3%AE-adrenergic-receptor-promotes-cellular-proliferation-in-human-glioblastoma
#20
Jing-Jing He, Wen-Hua Zhang, Shi-Ling Liu, Yi-Fang Chen, Chen-Xi Liao, Qian-Qing Shen, Ping Hu
Glioblastoma multiforme is the most common and aggressive form of primary malignant brain tumor. Previous evidence demonstrates that β-adrenergic receptors (β-ARs) are closely associated with the occurrence and development of brain tumors. However, the functional role of β-ARs in human glioblastoma and the underlying mechanisms are not fully understood. In the present study, by using the MTT assay, western blotting, and the reverse transcription polymerase chain reaction, it was revealed that isoproterenol (ISO), an agonist of β-ARs, promoted the proliferation of U251 cells but not U87-MG cells, and that this effect was blocked by the β-ARs antagonist propranolol...
September 2017: Oncology Letters
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