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https://www.readbyqxmd.com/read/28075458/silencing-of-forkhead-box-d1-inhibits-proliferation-and-migration-in-glioma-cells
#1
Yuan-Feng Gao, Tao Zhu, Xiao-Yuan Mao, Chen-Xue Mao, Ling Li, Ji-Ye Yin, Hong-Hao Zhou, Zhao-Qian Liu
Despite the extensive role of Forkhead box transcription factors in the development and progression of various cancers, little is known about their role in glioma. We examined the expression and function of Forkhead box D1 (FOXD1) in glioma cell behavior and found that FOXD1 was upregulated and directly correlated with the glioma grade. Data analysis also revealed significant differences in FOXD1 expression for both gene expression profiles (GSE4290 and GSE7696) and the TCGA datasets. Additionally, decreased FOXD1 expression in U251 and U87 glioma cells caused a delay in cell growth and a disruption in colony formation...
January 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28061901/rbm5-inhibits-tumorigenesis-of-gliomas-through-inhibition-of-wnt-%C3%AE-catenin-signaling-and-induction-of-apoptosis
#2
Yuanpei Jiang, Hongling Sheng, Lei Meng, Hongsheng Yue, Bo Li, Aijun Zhang, Yanan Dong, Yuguang Liu
BACKGROUND: Gliomas are one of the most common malignant brain tumors and bring a big threat to human life as traditional therapy is unsatisfactory. RBM5 was a RNA-binding motif protein and was reported as a tumor suppressor. But the role of RBM5 in gliomas was unknown. METHODS: The mRNA level of RBM5 was determined in gliomas tissues and cell lines by real-time quantitative PCR (qRT-PCR) assay while the association of RBM5 expression with prognosis was analyzed by Kaplan-Meier method and compared by log-rank test...
January 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28057017/the-brain-penetrating-cxcr4-antagonist-prx177561-increases-the-antitumor-effects-of-bevacizumab-and-sunitinib-in-preclinical-models-of-human-glioblastoma
#3
Giovanni Luca Gravina, Andrea Mancini, Francesco Marampon, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Peter J Richardson, Lee Patient, Stephen Burbidge, Claudio Festuccia
BACKGROUND: Glioblastoma recurrence after treatment with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is characterized by a highly infiltrative and malignant behavior that renders surgical excision and chemotherapy ineffective. It has been demonstrated that anti-VEGF/VEGFR therapies control the invasive phenotype and that relapse occurs through the increased activity of CXCR4. We therefore hypothesized that combining bevacizumab or sunitinib with the novel CXCR4 antagonist, PRX177561, would have superior antitumor activity...
January 5, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28035389/role-of-mir-223-paired-box-6-signaling-in-temozolomide-chemoresistance-in-glioblastoma-multiforme-cells
#4
Quan Cheng, Xiaoqiang Ma, Hui Cao, Zigui Chen, Xin Wan, Rui Chen, Renjun Peng, Jun Huang, Bing Jiang
Glioblastoma (GBM) is the predominant and most fatal type of brain tumor in adults. The prognosis of GBM remains poor despite advances in surgery, chemotherapy and radiotherapy. It is common that patients with GBM exhibit innate or acquired resistance to temozolomide (TMZ), a standard chemotherapeutic agent for GBM, and a previous report demonstrated that miRNA‑233 (miR‑223) promotes the growth and invasion of GBM cells by targeting tumor suppressor paired box 6 (PAX6). The present study explored the effect of TMZ on miR‑223/PAX6 signaling in addition to the effect of miR‑223/PAX6 signaling on TMZ chemoresistance in human GBM cells...
December 27, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28026047/rf-emf-exposure-at-1800%C3%A2-mhz-did-not-elicit-dna-damage-or-abnormal-cellular-behaviors-in-different-neurogenic-cells
#5
Liling Su, Xiaoxia Wei, Zhengping Xu, Guangdi Chen
Despite many years of studies, the debate on genotoxic effects of radiofrequency electromagnetic fields (RF-EMF) continues. To systematically evaluate genotoxicity of RF-EMF, this study examined effects of RF-EMF on DNA damage and cellular behavior in different neurogenic cells. Neurogenic A172, U251, and SH-SY5Y cells were intermittently (5 min on/10 min off) exposed to 1800 MHz RF-EMF at an average specific absorption rate (SAR) of 4.0 W/kg for 1, 6, or 24 h. DNA damage was evaluated by quantification of γH2AX foci, an early marker of DNA double-strand breaks...
December 27, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/28000106/knockdown-of-nupr1-inhibits-the-proliferation-of-glioblastoma-cells-via-erk1-2-p38-mapk-and-caspase-3
#6
Jun Li, Siyang Ren, Yongjian Liu, Zhigang Lian, Bin Dong, Yiqun Yao, Yinghui Xu
Nuclear protein-1 (NUPR1), located on chromosome 16p11.2, is a stress response factor that plays an important role in the growth and migration of human malignant tumor cells. However, the role of NUPR1 in glioblastoma remains poorly understood. The expression level of NUPR1 was detected by quantitative real-time PCR and immunohistochemistry (IHC). Wound healing, MTT, cell counting and BrdU assays were used to analyze the migration and proliferation of glioblastoma cells after down-regulating NUPR1 expression using a lentiviral vector...
December 20, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27995497/induction-of-g1-cell-cycle-arrest-in-human-glioma-cells-by-salinomycin-through-triggering-ros-mediated-dna-damage-in-vitro-and-in-vivo
#7
Shi-Jun Zhao, Xian-Jun Wang, Qing-Jian Wu, Chao Liu, Da-Wei Li, Xiao-Ting Fu, Hui-Fang Zhang, Lu-Rong Shao, Jing-Yi Sun, Bao-Liang Sun, Jing Zhai, Cun-Dong Fan
Chemotherapy has always been one of the most effective ways in combating human glioma. However, the high metastatic potential and resistance toward standard chemotherapy severely hindered the chemotherapy outcomes. Hence, searching effective chemotherapy drugs and clarifying its mechanism are of great significance. Salinomycin an antibiotic shows novel anticancer potential against several human tumors, including human glioma, but its mechanism against human glioma cells has not been fully elucidated. In the present study, we demonstrated that salinomycin treatment time- and dose-dependently inhibited U251 and U87 cells growth...
December 19, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27989700/cathepsin-l-is-involved-in-x-ray-induced-invasion-and-migration-of-human-glioma-u251-cells
#8
Yajie Xiong, Wenjun Ji, Yao Fei, Yifan Zhao, Long Wang, Wenjuan Wang, Meilin Han, Caihong Tan, Xifeng Fei, Qiang Huang, Zhongqin Liang
An important therapeutic method of glioblastoma, the most common primary brain tumor, is radiotherapy. However, several studies reported recently that radiation could also promote the invasion and migration of malignant tumor. Herein, we have identified that a significant increase of migration and invasiveness of human glioma U251 cells undergoing X-ray was observed compared to controls, accompanied by the increase of cathepsin L (CTSL), which is a lysosomal cysteine protease overexpressed and secreted by tumor cells...
October 29, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27988363/in-vitro-antiglioma-action-of-indomethacin-is-mediated-via-amp-activated-protein-kinase-mtor-complex-1-signalling-pathway
#9
Aleksandar Pantovic, Mihajlo Bosnjak, Katarina Arsikin, Milica Kosic, Milos Mandic, Biljana Ristic, Jelena Tosic, Danica Grujicic, Aleksandra Isakovic, Nikola Micic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
We investigated the role of the intracellular energy-sensing AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the in vitro antiglioma effect of the cyclooxygenase (COX) inhibitor indomethacin. Indomethacin was more potent than COX inhibitors diclofenac, naproxen, and ketoprofen in reducing the viability of U251 human glioma cells. Antiglioma effect of the drug was associated with p21 increase and G2M cell cycle arrest, as well as with oxidative stress, mitochondrial depolarization, caspase activation, and the induction of apoptosis...
December 14, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27983535/e2f-transcription-factors-associated-with-up-regulated-genes-in-glioblastoma
#10
Flávia S Donaires, Paulo R D V Godoy, Giovana S Leandro, Elza T Sakamoto-Hojo
BACKGROUND: Glioblastoma corresponds to the most common and malignant brain tumor in adults. Patients have a median survival of approximately one year from diagnosis due to poor response to therapy. OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in an attempt to point out molecular targets for therapy. METHODS: Up-regulated genes in glioblastoma selected from public microarray data were submitted to two TF association analyses...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27981546/lncrna-h19-is-overexpressed-in-glioma-tissue-is-negatively-associated-with-patient-survival-and-promotes-tumor-growth-through-its-derivative-mir-675
#11
T Zhang, Y-R Wang, F Zeng, H-Y Cao, H-D Zhou, Y-J Wang
OBJECTIVE: Glioma is one of the most common and invasive tumors of the central nervous system. Long non-coding (lnc) RNAs are involved in many cancers, but their function and mechanism in glioma remain largely unknown. We wished to delineate the role of lncRNA H19 and its derivative miR-675 in this tumor. PATIENTS AND METHODS: Using qPCR, we compared expression of lncRNA H19 in 35 specimens of glioma vs control tissue, and in two glioma cell lines U251 and U87 vs Normal Human Astrocyte (NHA) cells...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27977512/schisandrin-b-inhibits-the-proliferation-and-invasion-of-glioma-cells-by-regulating-the-hotair-micorna-125a-mtor-pathway
#12
Yan Jiang, Qiuli Zhang, Jinsuo Bao, Chenghua Du, Jian Wang, Qiang Tong, Chang Liu
Glioma is one of the most common malignant central nervous system tumors in humans. Schisandrin B (Sch B) has been confirmed to cause the proliferation and invasion of glioma cells. In the present study, the potential mechanism underlying the antitumor effect of Sch B on glioma cells was investigated. The glioma cell lines, U251 and U87, were exposed to Sch B, and the cell viability, apoptosis, migration, and invasion were determined using the MTT assay, flow cytometry, and transwell assay, respectively. Then, the effects of HOTAIR and miR-125a on tumor biology and the mammalian target of rapamycin (mTOR) protein expression in cell lines exposed to Sch B were investigated...
January 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/27958323/differential-transcription-profiles-of-long-non-coding-rnas-in-primary-human-brain-microvascular-endothelial-cells-in-response-to-meningitic-escherichia-coli
#13
Ruicheng Yang, Fei Huang, Jiyang Fu, Beibei Dou, Bojie Xu, Ling Miao, Wentong Liu, Xiaopei Yang, Chen Tan, Huanchun Chen, Xiangru Wang
Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown. By RNA-sequencing, the transcriptional profiles of host lncRNAs in primary human brain microvascular endothelial cells (hBMECs) in response to meningitic Escherichia coli were demonstrated. Here, 25,257 lncRNAs were identified, including 24,645 annotated lncRNAs and 612 newly found ones...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27957488/oxymatrine-inhibits-proliferation-and-migration-while-inducing-apoptosis-in-human-glioblastoma-cells
#14
Feili Liu, Baocheng Wang, Jiajia Wang, Xiaozheng Ling, Qifeng Li, Wei Meng, Jie Ma
Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer cells. In this study, we investigate the anticancer properties of OMT on human glioblastoma (GBM) cells and evaluate their underlying mechanisms. MTT assays were performed and demonstrated that OMT significantly inhibits the proliferation of GBM cells. Flow cytometry suggested that OMT at a concentration of 10(-5) M may induce apoptosis in U251 and A172 cells...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27955817/corrigendum-to-cathepsin-l-is-involved-in-x-ray-induced-invasion-and-migration-of-human-glioma-u251-cells-cell-signal-29-2017-181-191
#15
Yajie Xiong, Wenjun Ji, Yao Fei, Yifan Zhao, Long Wang, Wenjuan Wang, Meilin Han, Caihong Tan, Xifeng Fei, Qiang Huang, Zhongqin Liang
No abstract text is available yet for this article.
December 8, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27938503/microrna-181b-inhibits-cellular-proliferation-and-invasion-of-glioma-cells-via-targeting-sal-like-protein-4
#16
Yu Zhou, Yong Peng, Min Liu, Yugang Jiang
MicroRNAs (miRs), a class of 18-25 nucleotides in length non-coding RNAs, are able to suppress gene expression by targeting complementary regions of mRNAs and inhibiting protein translation Recently, miR-181b was found to playa suppressive role in glioma, but the regulatory mechanism of miR-181b in the malignant phenotypes of glioma cells remains largely unclear. Here we found that miR-181b was significantly downregulated in glioma tissues when compared with normal brain tissues, and decreased miR-181b levels were significantly associated with high pathology grade and poor prognosis of patients with glioma...
November 17, 2016: Oncology Research
https://www.readbyqxmd.com/read/27926485/axitinib-induces-senescence-associated-cell-death-and-necrosis-in-glioma-cell-lines-the-proteasome-inhibitor-bortezomib-potentiates-axitinib-induced-cytotoxicity-in-a-p21-waf-cip1-dependent-manner
#17
Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Claudio Cardinali, Matteo Santoni, Giovanni Bernardini, Angela Santoni, Giorgio Santoni
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27916196/adaptive-activation-of-a-stress-response-pathway-improves-learning-and-memory-through-gs-and-%C3%AE-arrestin-1-regulated-lactate-metabolism
#18
Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W Kahsai, Thomas Joseph Cahill, Zhe-Yu Chen, Xiao Yu, Jin-Peng Sun
BACKGROUND: Stress is a conserved physiological response in mammals. Whereas moderate stress strengthens memory to improve reactions to previously experienced difficult situations, too much stress is harmful. METHODS: We used specific β-adrenergic agonists, as well as β2-adrenergic receptor (β2AR) and arrestin knockout models, to study the effects of adaptive β2AR activation on cognitive function using Morris water maze and object recognition experiments. We used molecular and cell biological approaches to elucidate the signaling subnetworks...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27911270/saha-and-or-mg132-reverse-the-aggressive-phenotypes-of-glioma-cells-an-in-vitro-and-vivo-study
#19
Xue-Feng Yang, Zhi-Juan Zhao, Jia-Jie Liu, Xiang-Hong Yang, Yang Gao, Shuang Zhao, Shuai Shi, Ke-Qiang Huang, Hua-Chuan Zheng
To elucidate the anti-tumor effects and molecular mechanisms of SAHA (a histone deacetylase inhibitor) and MG132 (a proteasome inhibitor) on the aggressive phenotypes of glioma cells, we treated U87 and U251 cells with SAHA or/and MG132, and detected phenotypes' assays with phenotype-related molecules examined. It was found that SAHA or/and MG132 treatment suppressed proliferation in both concentration- and time-dependent manners, inhibited energy metabolism, migration, invasion and lamellipodia formation, and induced G2 arrest and apoptosis in the glioma cells...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909720/tetrandrine-inhibits-glioma-stem-like-cells-by-repressing-%C3%AE-catenin-expression
#20
Yong Zhang, Yu-Lin Wen, Ji-Wei Ma, Jie-Cheng Ye, Xiao Wang, Jian-Xian Huang, Chao-Yue Meng, Xiao-Ze Xu, Shao-Xiang Wang, Xue-Yun Zhong
Cancer stem cells (CSCs) in glioma are often responsible for relapse and resistance to therapy. The purpose of the present study was to confirm the self-renewal and migration inhibitory effects of tetrandrine (Tet), which is a compound extracted from the dried root of Stephania tetrandra S. Moore, toward glioma stem-like cells (GSLCs) and to examine the associated molecular mechanisms. Using a neurosphere culture technique, we enriched the GSLC population from the human glioblastoma cell lines U87 and U251...
January 2017: International Journal of Oncology
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