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https://www.readbyqxmd.com/read/28327666/hypoxia-induces-h19-expression-through-direct-and-indirect-hif-1%C3%AE-activity-promoting-oncogenic-effects-in-glioblastoma
#1
Weining Wu, Qi Hu, Er Nie, Tianfu Yu, Youzhi Wu, Tongle Zhi, Kuan Jiang, Feng Shen, Yingyi Wang, Junxia Zhang, Yongping You
H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet the upregulation of H19 in glioblastomas remains unclear. Here we report that hypoxia significantly stimulated H19 expression in glioblastoma cell lines, which was related to hypoxia-inducible factors 1α (Hif-1α). Hif-1α promoted H19 expression in U87 and U251 cells. Meanwhile PTEN is an advantageous factor to affect H19 expression, through attenuating Hif-1α stability. Hif-1α also positively correlates with H19 in human glioblastoma samples depending on PTEN status...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314270/global-microrna-expression-profiling-identifies-unique-microrna-pattern-of-radioresistant-glioblastoma-cells
#2
Jakub Ondracek, Pavel Fadrus, Jiri Sana, Andrej Besse, Tomas Loja, Marek Vecera, Lenka Radova, Martin Smrcka, Pavel Slampa, Ondrej Slaby
Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the presence of tumor cells resistant to conventional therapy, mainly radiotherapy. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and have been repeatedly proven to play important roles in pathogenesis and biological features of many cancers, including GBM and its radioresistant phenotype...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28281379/%C3%AE-pyrone-derivatives-from-a-marine-actinomycete-nocardiopsis-sp-yim-m13066
#3
Xiao-Mei Zhang, Ming-Wei Sun, Hui Shi, Chun-Hua Lu
Five new α-pyrones namely nocapyrones O-S (2-6) and nocapyrone F (1) were isolated from a deep-sea sediment strain Nocardiopsis sp. YIM M13066. Their structures were elucidated by their NMR spectroscopic data, HR-ESI-MS and crystal X-ray diffraction. Their cytotoxic activities against H1299, HeLa, HL7702, MCF-7, PC3 and U251 cell lines were evaluated.
March 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28276316/long-noncoding-rna-meg3-suppresses-glioma-cell-proliferation-migration-and-invasion-by-acting-as-competing-endogenous-rna-of-mir-19a
#4
Gui-Feng Tong, Nan Qin, Li-Wei Sun, Xiao-Lin Xu
Glioma, with varying malignancy grades and histological subtypes, is the commonest primary brain tumor in adults. Longnon-coding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play important roles in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA MEG3 and microRNA-19a in human glioma U87 and U251 cell lines. Real time PCR revealed that MEG3 was down-regulated and miR-19a was up-regulated in malignant glioma tissues and cell lines. Bioinformatics analyses (TargetScan, miRanda and starBase V2...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28272313/optimization-of-ultrasonic-assisted-enzymatic-extraction-conditions-for-improving-total-phenolic-content-antioxidant-and-antitumor-activities-in-vitro-from-trapa-quadrispinosa-roxb-residues
#5
Feng Li, Yi-Dan Mao, Yi-Fan Wang, Aun Raza, Li-Peng Qiu, Xiu-Quan Xu
Stems are the important residues of Trapa quadrispinosa Roxb., which are abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel extraction technology with main advantages of enhancing extraction yield and physiological activities of the extracts from various plants. In this study, UAEE was applied to obtain the highest yield of phenolic content, strongest antioxidant, and antitumor activities and to optimize the extraction conditions using response surface methodology (RSM)...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28262948/swelling-induced-chloride-current-in-glioblastoma-proliferation-migration-and-invasion
#6
Raymond Wong, Wenliang Chen, Xiao Zhong, James T Rutka, Zhong-Ping Feng, Hong-Shuo Sun
Glioblastoma (GBM) remains as the most common and aggressive brain tumor. The survival of GBM has been linked to the aberrant activation of swelling-induced chloride current ICl,swell . In this study, we investigated the effects of ICl,swell on cell viability, proliferation and migration in the human GBM cell lines, U251 and U87, using a combination of patch clamp electrophysiology, MTT, colony formation, wound healing assays and Western immunoblotting. First, we showed that the specific inhibitor of ICl,swell , DCPIB, potently reduced the ICl,swell in U87 cells...
March 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28260920/tbx2-confers-poor-prognosis-in-glioblastoma-and-promotes-temozolomide-resistance-with-change-of-mitochondrial-dynamics
#7
Fuxin Yi, Jianzhou Du, Weimin Ni, Weixian Liu
Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining. Negative Tbx2 staining was observed in normal astrocytes, and positive nuclear staining was found in 41 out of 102 astrocytoma specimens. The rate of Tbx2 overexpression in pylocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma multiform (GBM) were 0%, 26...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28260024/foxo3a-induces-temozolomide-resistance-in-glioblastoma-cells-via-the-regulation-of-%C3%AE-catenin-nuclear-accumulation
#8
Ke Xu, Zhenhao Zhang, Hua Pei, Huamin Wang, Liang Li, Qianfeng Xia
Glioblastoma multiforme (GBM), the most common malignant brain tumor, is currently treated with temozolomide (TMZ), but GBM often exhibits resistance to TMZ. Although several mechanisms underlying GBM resistance to TMZ have been identified, these mechanisms are yet to fully explain how GBM gains resistance to TMZ. Our previous work has shown that FoxO3a, a member of the FoxO subfamily of transcription factors, promotes glioma cell proliferation and invasion. In this study, we sought to determine whether FoxO3a participates in TMZ resistance in GBM cells...
February 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28260004/gsh-depletion-and-consequent-akt-inhibition-contribute-to-the-nrf2-knockdown-induced-decrease-in-proliferation-in-glioblastoma-u251-cells
#9
Yue Jia, Han-Dong Wang, Qiang Wang, Hui Ding, He-Ming Wu, Hao Pan
Nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal transcription regulator that controls the expression of numerous antioxidant and cytoprotective genes, was recently defined as a proto-oncogene. However, the role and mechanism of Nrf2 in glioma pathoetiology remain unclear. In the present study, we first evaluated the expression patterns of Nrf2 in normal human astrocytes and 3 glioblastoma (GBM) cell lines (U251, U87 and A172) and found that all 3 GBM cell lines overexpressed Nrf2, with the highest level observed in the U251 cells...
February 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28259970/iqgap1%C3%A2-sirna-inhibits-proliferation-and-metastasis-of-u251-and-u373-glioma-cell-lines
#10
Bo Diao, Ying Liu, Yi Zhang, Jing Yu, Jun Xie, Guo-Zheng Xu
IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research of tumors. The present study aimed to explore the effects of IQGAP1‑small interfering (si) NA on the proliferation and metastasis of U251 and U373 glioma cell lines, which markedly expressed IQGAP1...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28256591/nicotinic-acid-inhibits-glioma-invasion-by-facilitating-snail1-degradation
#11
Jiejing Li, Jiagui Qu, Yu Shi, Mark Perfetto, Zhuxian Ping, Laura Christian, Hua Niu, Shuting Mei, Qin Zhang, Xiangcai Yang, Shuo Wei
Malignant glioma is a formidable disease that commonly leads to death, mainly due to the invasion of tumor cells into neighboring tissues. Therefore, inhibition of tumor cell invasion may provide an effective therapy for malignant glioma. Here we report that nicotinic acid (NA), an essential vitamin, inhibits glioma cell invasion in vitro and in vivo. Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied by a loss of mesenchymal phenotype and an increase in cell-cell adhesion...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28243617/data-supporting-the-inability-of-indomethacin-to-induce-autophagy-in-u251-glioma-cells
#12
Aleksandar Pantovic, Katarina Arsikin, Milica Kosic, Biljana Ristic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Autophagy, a catabolic process involving intracellular degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery, could act as a prosurvival, as well as a cytotoxic mechanism (Parzych and Klionsky, 2014) [1]. Cyclooxygenase inhibitor indomethacin inhibits proliferation of glioma cells, and has been reported to reduce the activity of the main autophagy repressor mammalian target of rapamycin (mTOR) (Pantovic et al., 2016) [2]. Here we investigated the ability of indomethacin to induce autophagy in U251 human glioma cells...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28219405/ttbk2-circular-rna-promotes-glioma-malignancy-by-regulating-mir-217-hnf1%C3%AE-derlin-1-pathway
#13
Jian Zheng, Xiaobai Liu, Yixue Xue, Wei Gong, Jun Ma, Zhuo Xi, Zhongyou Que, Yunhui Liu
BACKGROUND: Circular RNAs are a subgroup of non-coding RNAs and generated by a mammalian genome. Herein, the expression and function of circular RNA circ-TTBK2 were investigated in human glioma cells. METHODS: Fluorescence in situ hybridization and quantitative real-time PCR were conducted to profile the cell distribution and expression of circ-TTBK2 and microRNA-217 (miR-217) in glioma tissues and cells. Immunohistochemical and western blot were used to determine the expression of HNF1β and Derlin-1 in glioma tissues and cells...
February 20, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28218292/hyperthermia-and-chemotherapy-using-fe-salen-nanoparticles-might-impact-glioblastoma-treatment
#14
Makoto Ohtake, Masanari Umemura, Itaru Sato, Taisuke Akimoto, Kayoko Oda, Akane Nagasako, Jeong-Hwan Kim, Takayuki Fujita, Utako Yokoyama, Tomohiro Nakayama, Yujiro Hoshino, Mai Ishiba, Susumu Tokura, Masakazu Hara, Tomoya Muramoto, Sotoshi Yamada, Takatsugu Masuda, Ichio Aoki, Yasushi Takemura, Hidetoshi Murata, Haruki Eguchi, Nobutaka Kawahara, Yoshihiro Ishikawa
We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216618/1-2-5-6-dianhydrogalactitol-inhibits-human-glioma-cell-growth-in-vivo-and-in-vitro-by-arresting-the-cell-cycle-at-g2-m-phase
#15
Chun Peng, Xin-Ming Qi, Ling-Ling Miao, Jin Ren
1,2:5,6-dianhydrogalactitol (DAG) is a hexitol epoxide with marked antitumor activity against multiple types of cancer cells, but the molecular mechanisms by which DAG functions as an antitumor agent is largely unknown. In this study, we investigated the inhibitory effects of DAG on human glioma cell growth in vitro and in vivo and uncovered the underlying molecular mechanisms. Treatment with DAG (120 μmol/L) dose-dependently inhibited the proliferation and colony formation in human glioma cell lines LN229, U251, and U87MG in vitro...
February 20, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28197071/chemosensitivity-of-u251-cells-to-the-co-treatment-of-d-penicillamine-and-copper-possible-implications-on-wilson-disease-patients
#16
Meghri Katerji, Kassem Barada, Mustapha Jomaa, Firas Kobeissy, Ahmad-Kareem Makkawi, Wassim Abou-Kheir, Julnar Usta
D-Penicillamine (PA), a copper chelator, and one of the recommended drugs for treatment of Wilson disease (WD) has been reported to worsen the symptoms of patients with neurologic presentations. However, the cause of this paradoxical response has not been fully elucidated and requires further investigations. Accordingly, we have studied the in vitro effect of Copper (Cu) and/or PA treatment on human glioblastoma U251 cells as an in vitro model of Cu cytotoxicity. Treatment of U251 cells with either Cu or PA exerted no significant effect on their morphology, viability or ROS level...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28187755/long-noncoding-rna-papillary-thyroid-carcinoma-susceptibility-candidate-3-ptcsc3-inhibits-proliferation-and-invasion-of-glioma-cells-by-suppressing-the-wnt-%C3%AE-catenin-signaling-pathway
#17
Shujun Xia, Ri Ji, Weiwei Zhan
BACKGROUND: The dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, such as proliferation, invasion and differentiation. Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a novel lncRNA that was primarily detected in papillary thyroid carcinoma. However, the biological function and molecular mechanism of lncRNA PTCSC3 in glioma are still unknown...
February 10, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28185834/eva1a-inhibits-gbm-cell-proliferation-by-inducing-autophagy-and-apoptosis
#18
Xue Shen, Shifeng Kan, Zhen Liu, Guang Lu, Xiaoyan Zhang, Yingyu Chen, Yun Bai
Eva-1 homolog A (EVA1A) is a novel lysosome and endoplasmic reticulum-associated protein involved in autophagy and apoptosis. In this study, we constructed a recombinant adenovirus 5-EVA1A vector (Ad5-EVA1A) to overexpress EVA1A in glioblastoma (GBM) cell lines and evaluated its anti-tumor activities in vitro and in vivo. We found that overexpression of EVA1A in three GBM cell lines (U251, U87 and SHG44) resulted in a suppression of tumor cell growth via activation of autophagy and induction of cell apoptosis in a dose- and time-dependent manner...
March 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28184932/microrna-520c-inhibits-glioma-cell-migration-and-invasion-by-the-suppression-of-transforming-growth-factor-%C3%AE-receptor-type%C3%A2-2
#19
Shengli Hu, Huibin Chen, Yuqiang Zhang, Chaojia Wang, Kaijun Liu, Hui Wang, Jie Luo
Dysregulation of microRNAs (miRNAs) is actively involved in the development and progression of glioma. miR-520c was previously found to inhibit glioblastoma cell migration. However, the clinical significance of miR-520c and its biological function in glioma remain largely unknown. In the present study, we found that miR-520c expression in glioma tissues was significantly decreased compared to adjacent non‑cancerous tissues. The low level of miR-520c was prominently correlated with advanced World Health Organization (WHO) grade and decreased overall survival of glioma patients...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28168193/proliferative-and-invasive-effects-of-progesterone-induced-blocking-factor-in-human-glioblastoma-cells
#20
Araceli Gutiérrez-Rodríguez, Valeria Hansberg-Pastor, Ignacio Camacho-Arroyo
Progesterone-induced blocking factor (PIBF) is a progesterone (P4) regulated protein expressed in different types of high proliferative cells including astrocytomas, the most frequent and aggressive brain tumors. It has been shown that PIBF increases the number of human astrocytoma cells. In this work, we evaluated PIBF regulation by P4 and the effects of PIBF on proliferation, migration, and invasion of U87 and U251 cells, both derived from human glioblastomas. PIBF mRNA expression was upregulated by P4 (10 nM) from 12 to 24 h...
2017: BioMed Research International
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