Natália Pontes Bona, Nathalia Stark Pedra, Luiza Spohr, Francieli da Silva Dos Santos, Juliane Torchelsen Saraiva, Fabiano Barbosa Carvalho, Marilda da Cruz Fernandes, Ana Sofia Fernandes, Nuno Saraiva, Marta Filipa Martins, Rejane Giacomelli Tavares, Roselia Maria Spanevello, Mayara Sandrielly Soares de Aguiar, Francieli Moro Stefanello
The aim of this study was to investigate the antiglioma effect of Cecropia pachystachya Trécul (CEC) leaves extract against C6 and U87 glioblastoma (GB) cells and in a rat preclinical GB model. The CEC extract reduced in vitro cell viability and biomass. In vivo, the extract decreased the tumor volume approximately 62%, without inducing systemic toxicity. The deficit in locomotion and memory and an anxiolytic-like behaviors induced in the GB model were minimized by CEC. The extract decreased the levels of reactive oxygen species, nitrites and thiobarbituric acid reactive substances and increased the activity of antioxidant enzymes in platelets, sera and brains of GB animals...
March 14, 2024: Molecular Neurobiology