aureus and gpa

58S bioactive glass (BG) has effective biocompatibility and bioresorbable properties for bone tissue engineering; however, it has limitations regarding antibacterial, antioxidant, and mechanical properties. Therefore, we have developed BGAC biocomposites by reinforcing 58S BG with silver and ceria nanoparticles, which showed effective bactericidal properties by forming inhibited zones of 2.13 mm (against Escherichia coli ) and 1.96 mm (against Staphylococcus aureus ; evidenced by disc diffusion assay) and an increment in the antioxidant properties by 39...

Si3 N4 bioceramics were fabricated using GPS and SPS method with MgO-RE2 O3 (RE = La, Nd, Gd, Ho and Lu) sintering additives. The effect of sintering methods and sintering additives on the grain growth, mechanical, antimicrobial properties and color of Si3 N4 bioceramics were studied. Samples sintered with GPS are composed of β-Si3 N4 and samples sintered with SPS are composed of α-Si3 N4 and β-Si3 N4 . The growth of β-Si3 N4 grains in samples sintered with GPS are more adequate...

Among the different surface modification techniques, micro-arc oxidation (MAO) is explored for its ability to enhance the surface properties of Ti alloys by creating a controlled and durable oxide layer. The incorporation of Cu ions during the MAO process introduces additional functionalities to the surface, offering improved corrosion resistance and antimicrobial activity. In this study, the β-metastable Ti-30Nb-5Mo alloy was oxidated through the MAO method to create a Cu-doped TiO2 coating. The quantity of Cu ions in the electrolyte was changed (1...

Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease. Major contribution of HLA genes have been reported; however, HLA typing-based diagnosis or risk-prediction in GPA has not been established. We have performed a sequencing-based HLA-genotyping in a north Indian GPA cohort and controls to identify clinically relevant novel associations. PR3-ANCA-positive 40 GPA patients and 40 healthy controls from north India were recruited for the study. Targeted sequencing of HLA-A,-B,-C,-DRB1,-DQB1, and -DPB1 was performed...

Conventional three-dimensional (3D)-printed hydroxyapatite (HA)-based constructs have limited utility in bone tissue engineering due to their poor mechanical properties, elevated risk of microbial infection, and limited pore interconnectivity. 3D printing of complex multiple components to fabricate fully interconnected scaffolds is a challenging task; here, in this work, we have developed a procedure for fabrication of printable ink for complex systems containing multinanomaterials, i.e., HAACZ (containing 1 wt % Ag, 4 wt % CeO2 , and 6 wt % ZnO) with better shear thinning and shape retention properties...

In dentistry, the most commonly used implant materials are CP-Titanium Grade 4 and Ti-6Al-4V ELI, possessing comparably high Young's modulus (>100 GPa). In the present study, the second-generation titanium alloy Ti-13Nb-13Zr is investigated with respect to the production of advanced dental implant systems. This should be achieved by the fabrication of long semi-finished bars with high strength and sufficient ductility to allow the automated production of small implants at low Young's modulus (<80 GPa) to minimize stress shielding, bone resorption, and gap formation between the bone and implant...

Medicinal plants play a prodigious role in the wound-healing process. Tridax procumbens (TP) has been proven to show strong antimicrobial activity against Staphylococcus aureus and could heal skin infections. Identifying mechanical properties of TP in his solid state and mixed with carboxymethylcellulose (CMC) have never been studied before. In this study, fresh TP liquid extracts blended with carboxymethylcellulose (CMC) biofilm were developed through the solution casting method. The casted film was tested for tensile strength through the Universal Tensile Tester (UTT), and the results were compared with the Finite Element Numerical Model (FEM) through the FEM code developed on the ANSYS solver...

Chronic nasal carriage of Staphylococcus aureus (SA) has been shown to be significantly higher in GPA patients when compared to healthy subjects, as well as being associated with increased endonasal activity and disease relapse. The aim of this study was to investigate SA involvement in GPA by applying a network-based analysis (NBA) approach to publicly available nasal transcriptomic data. Using these data, our NBA pipeline generated a proteinase 3 (PR3) positive ANCA associated vasculitis (AAV) disease network integrating differentially expressed genes, dysregulated transcription factors (TFs), disease-specific genes derived from GWAS studies, drug-target and protein-protein interactions...

All-cellulose composite (ACC) was directly fabricated by the partial-dissolution welding of cellulose microfibers from agro-residual corn stalks treated with low-concentration ZnCl2 solvent (10-40 %). The solvent infiltrated deeply into nano/micro-scaled pores of cellulose fibers to facilitate the free migration of the disordered chains among the cellulose network while leaving the fiber core undissolved. Then, these disordered chains would entangle and regenerate to serve as a welded layer to bond the undissolved microfibril core in the solvent removal process...

UNLABELLED: Epidemics caused by pathogens in recent years have created an urgent need for energetic biocidal agents with the capacity of detonation and releasing bactericides. Herein we present a new type of energetic biocidal agents based on a series of iodine-rich molecular perovskites, (H2 dabco)M(IO4 )3 (dabco = 1,4-diazabicyclo[2.2.2]octane, M = Na+ /K+ /Rb+ /NH4 + for DAI-1/2/3/4) and (H2 dabco)Na(H4 IO6 )3 (DAI-X1). These compounds possess a cubic perovskite structure, and notably have not only high iodine contents (49-54 wt%), but also high performance in detonation velocity (6...

As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility. In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system. Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method. The AIMC12 exhibited the highest antibacterial activity. Under the optimized ratio of CMC to SR, the AIMCS-1-1 film showed effective antibacterial properties for E...

Recombinant spider silk materials with antimicrobial peptides are a promising new class of drug-free antimicrobial materials capable of preventing surgical site infections (SSI), but their potential to impede infections is unclear. Herein, we aimed to unravel the biological and inflammatory potential of bioengineered spider silk materials to prevent SSI using an infection animal model. Silk-like fibers made of silk fibroin and spider silk proteins with antimicrobial peptides (6mer-HNP1) held improved stiffness (2...

The development a photochemically driven polymeric composite for dental restorative materials to restore tooth cavities with antibacterial, biocompatibility, and outstanding mechanical properties is an urgent need for clinical application in stomatology. Herein, a series of polyurethane acrylate (PUA) prepolymers and antibacterial polyurethane acrylate quaternary ammonium salts (PUAQASs) were synthesized, and their mechanical and biological properties were explored. The unique secondary mercaptan with a long shelf life and low odor was used to reduce oxygen inhibition and increase cross-linking density; meanwhile, modified photocurable nano zirconia (nano ZrO2 ) enhances mechanical properties of the nanocomposites and possesses preeminent dispersion in the matrix...

Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals ( n = 85), matched controls, and established AAV-patients ( n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons...

Chronic nasal carriage of Staphylococcus aureus (S. aureus) is a risk factor for relapse of granulomatosis with polyangiitis (GPA), and genetic susceptibility to infections and autoimmune diseases is majorly affected by HLA genes. Previous studies have shown the association of HLA Class-II genes with GPA susceptibility. Here, we aim to assess immune responses of GPA patients against S. aureus antigens in relation to the HLA-DR-DQ genes polymorphism to determine the disease outcome. A total of 45 GPA patients and 128 healthy controls during 2010-2012 were included in this case-control study...

Polyetheretherketone (PEEK) has been widely used in bone repair, but it often fails due to bacterial infection. Herein, a high-strength porous polyetheretherketone scaffold (ps-PK) loaded with antibacterial drug-loaded hydrogel strategy is proposed. The prepared ps-PK possesses high porosity (30.8%-64.7%) and the compression modulus is between 0.4-0.98 GPa. The interconnected pore-type structure endows it with a drug loading capacity. Poly(D,L -lactic acid-co-glycolic acid)-b-Poly(ethylene glycol)-b-Poly(D,L -lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) thermoresponsive hydrogels loaded with vancomycin are used as the drug sustained-release system...

This study intends to improve the antibacterial and mineralization performance of photocurable dental resin composites (DRC) to reduce the possibility of repair failure caused by secondary caries. To the end, functionalized hydroxyapatite (HAp), including Zn-doped (Zn/HAp) and Sr-doped HAp (Sr/HAp), were added into the bisphenol A glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) mixture, providing the DRCs with antibacterial and mineralization capacity, respectively. By controlling the total amount of inorganic filler at 70 wt%, these HAp powders were introduced into the resin matrix with barium glass powder (BaGP), while the ratios of HAp to GaBP varied from 0:70 to 8:62...

OBJECTIVE: Guided bone regeneration (GBR) techniques use barrier membranes to augment the alveolar ridge for the site-specific growth of bone defects. However, current approaches using cast metal substructures exhibit poor adaptation to the surgical site and increased risk of infection. This study aimed to fabricate multi-functional coatings with 3D-printed porous titanium-niobium (Ti-Nb) alloy meshes to maintain space, prevent the ingrowth of fibroblasts and inhibit the colonization of bacteria for GBR...

There is an increasing interest in the use of polyether ether ketone (PEEK) for biomedical applications. Herein, we have developed silver nanoparticles (AgNPs) decorated PEEK with gelatin (GEL) nanocomposite hydrogel with enhanced antibacterial and biocompatibility through the blending method. The prepared highly porous PEEK/GEL/AgNPs nanocomposite hydrogel was characterized using SEM, TEM, FT-IR, and XRD analysis. The SEM image showed that AgNPs were encapsulated in the porous PEEK/GEL hydrogel; within this porous hydrogel, the AgNPs were homogeneously dispersed...

Zirconia ceramics with high mechanical properties have been used as a load-bearing implant in the dental and orthopedic surgery. However, poor bone bonding properties and high elastic modulus remain a challenge. Calcium silicate (CaSi)-based ceramic can foster osteoblast adhesion, growth, and differentiation and facilitate bone ingrowth. This study was to prepare CaSi-ZrO2 composites and evaluate their mechanical properties, long-term stability, in vitro osteogenic activity, and antibacterial ability. The Escherichia coli ( E...