Susan M Graham, Robin M Nance, Junmei Chen, Jennie Le, Dominic W Chung, Mark M Wurfel, David L Tirschwell, Joseph R Zunt, Christina M Marra, Emily L Ho, Andrew Huffer, Felicia C Chow, Jeffrey N Martin, Alice S Ryan, Heidi M Crane, José A López, W Conrad Liles
Background: We assessed whether key biomarkers of endothelial activation and hemostasis/thrombosis were elevated in individuals receiving effective antiretroviral therapy (ART) in the year before ischemic stroke. Methods: We conducted a case-control study nested in the CFAR Network of Integrated Clinical Systems cohort, comparing 42 adjudicated cases with ischemic stroke with 83 controls matched for ART regimen. Angiopoietin-1, angiopoietin-2, C-reactive protein, interleukin-6, plasminogen activation inhibitor-1, P-selectin, serum amyloid-A, soluble CD14, ICAM-1, VCAM-1, apolipoprotein A1, ADAMTS13, and von Willebrand factor (VWF) were measured in stored plasma collected before the stroke event...
November 2021: Open Forum Infectious Diseases