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https://www.readbyqxmd.com/read/28214872/higher-numbers-of-t-bet-tumor-infiltrating-lymphocytes-associate-with-better-survival-in-human-epithelial-ovarian-cancer
#1
Yun Xu, Lujun Chen, Bin Xu, Yuqi Xiong, Min Yang, Xiaohui Rui, Liangrong Shi, Changping Wu, Jingting Jiang, Binfeng Lu
BACKGROUND/AIMS: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognostic value of T-bet+ tumor-infiltrating lymphocytes in human epithelial ovarian cancer. METHODS: The immunohistochemistry was used to analyze the infiltration density of T-bet+ lymphoid cells in human epithelial ovarian cancer tissues, and the flow cytometry analysis was used to further analyze the presence of T-bet+ tumor-infiltrating lymphocytes subgroups in cancer tissues...
January 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213870/molecular-characterization-of-bovine-leukemia-virus-from-moldovan-dairy-cattle
#2
Aneta Pluta, Marzena Rola-Łuszczak, Piotr Kubiś, Svetlana Balov, Roman Moskalik, Bhudipa Choudhury, Jacek Kuźmak
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), a disease that has worldwide distribution. Whilst it has been eradicated in most of Western Europe and Scandinavia, it remains a problem in other regions, particularly Eastern Europe and South America. For this study, in 2013, 24 cattle from three farms in three regions of Moldova were screened by ELISA and nested PCR. Of these cattle, 14 which were PCR positive, and these were molecularly characterized based on the nucleotide sequence of the env gene and the deduced amino acid sequence of the encoded gp51 protein...
February 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28213300/experiences-of-stigma-and-discrimination-faced-by-family-caregivers-of-people-with-schizophrenia-in-india
#3
Mirja Koschorke, R Padmavati, Shuba Kumar, Alex Cohen, Helen A Weiss, Sudipto Chatterjee, Jesina Pereira, Smita Naik, Sujit John, Hamid Dabholkar, Madhumitha Balaji, Animish Chavan, Mathew Varghese, R Thara, Vikram Patel, Graham Thornicroft
Stigma associated with schizophrenia significantly affects family caregivers, yet few studies have examined the nature and determinants of family stigma and its relationship to their knowledge about the condition. This paper describes the experiences and determinants of stigma reported by the primary caregivers of people living with schizophrenia (PLS) in India. The study used mixed methods and was nested in a randomised controlled trial of community care for people with schizophrenia. Between November 2009 and October 2010, data on caregiver stigma and functional outcomes were collected from a sample of 282 PLS-caregiver dyads...
February 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28199450/association-between-smoking-status-preoperative-exhaled-carbon-monoxide-levels-and-postoperative-surgical-site-infection-in-patients-undergoing-elective-surgery
#4
Margaret B Nolan, David P Martin, Rodney Thompson, Darrell R Schroeder, Andrew C Hanson, David O Warner
Importance: Cigarette smoking is a risk factor for many perioperative complications, including surgical site infection (SSI). The duration of abstinence from smoking required to reduce this risk is unknown. Objectives: To evaluate if abstinence from smoking on the day of surgery is associated with a decreased frequency of SSI in patients who smoke cigarettes and to confirm that smoking is significantly independently associated with SSI when adjustment is made for potentially relevant covariates, such as body mass index...
February 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28187589/palaearctic-i-protosmia-i-bees-of-the-subgenus-i-chelostomopsis%C3%A2-i-megachilidae-osmiini-biology-taxonomy-and-key-to-species
#5
Andreas Müller
Chelostomopsis represents a subgenus of the osmiine bee genus Protosmia (Megachilidae) containing three Palaearctic and one Nearctic species. Analysis of female pollen loads and literature data indicate that all Chelostomopsis species are broad pollen generalists exploiting the flowers of numerous plant families, such as Fabaceae, Asteraceae, Lamiaceae, Cistaceae and Brassicaceae. Preexisting linear cavities in dead wood or pine cones serve as nesting sites and pure resin is used to construct cell partitions and nest plug...
February 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28183865/compass-cues-used-by-a-nocturnal-bull-ant-myrmecia-midas
#6
Cody A Freas, Ajay Narendra, Ken Cheng
Ants use both terrestrial landmarks and cues derived from path integration to navigate to and from their nest location. These cues persist even as light levels drop during the twilight/night. Here we determined the compass cues used by a nocturnal bull ant, Myrmecia midas, in which the majority of the individuals begin foraging during the evening twilight period. Foragers of M. midas with vectors of≤5 m when displaced to unfamiliar locations did not follow the home vector, but instead showed random heading directions...
February 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28168110/nest-site-selection-reproductive-ecology-and-shifts-within-core-use-areas-of-black-necked-cranes-at-the-northern-limit-of-the-tibetan-plateau
#7
Lixun Zhang, Bei An, Meilin Shu, Xiaojun Yang
We investigated population dynamics, breeding pairs, breeding habitat selection, nest density, distance between neighboring nests, nest survival, reproductive success, and recruitment rate for Black-necked Cranes (BNC, Grus nigricollis) during 2013-2015 in Yanchiwan National Nature Reserve (YCW), Gansu, China. Numbers of BNC and breeding pairs remained relatively stable at around 140 individuals and 40 pairs. Recruitment rates ranged from 15.7% to 25.8%. The average nest distance was 718.66 ± 430.50 m (2013), 1064...
2017: PeerJ
https://www.readbyqxmd.com/read/28166941/keeping-it-regular-development-of-thermoregulation-in-four-tropical-seabird-species
#8
Lorinda A Hart, Colleen T Downs, Mark Brown
The thermoregulatory capacity of a species can determine which climatic niche it occupies. Its development in avian chicks is influenced by numerous factors. Furthermore, it is suggested that altricial chicks develop their thermoregulatory capacity post-hatching, while precocial chicks develop aspects of this in the egg. We investigated the development of thermoregulation of four co-occurring seabird species in the Seychelles; namely white, ground-nesting white-tailed tropicbirds (Phaethon lepturus) and tree-nesting fairy terns (Gygis alba); and dark plumaged, tree-nesting lesser noddies (Anous tenuirostris) and ground- and tree-nesting brown noddies (A...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28163970/garcinia-subelliptica-merr-fukugi-a-multipurpose-coastal-tree-with-promising-medicinal-properties
#9
REVIEW
Tomomi Inoue, Mami Kainuma, Karin Baba, Nozomi Oshiro, Norimi Kimura, Eric Wei Chiang Chan
In this short review, the current knowledge on the botany, ecology, uses, and medicinal properties of the multipurpose Garcinia subelliptica (Fukugi) is updated. As yet, there are no reviews on this indigenous and heritage coastal tree species of the Ryukyu Islands in Japan, which has ethnocultural, ecological, and pharmacological significance. Planted by the Okinawan people some 300 years ago, Fukugi trees serve as windbreaks and accord protection against the destructive typhoons. The species has become a popular ornamental tree, and its bark has been used for dyeing fabrics...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28161357/prevalence-of-resistant-associated-variants-ravs-in-the-na%C3%A3-ve-hcv-patient-candidate-for-direct-acting-antiviral-daa-therapy
#10
Mohammad Hadi Karbalaie Niya, Samira Salman-Tabar, Farah Bokharaei-Salim, Hossein Keyvani
BACKGROUND: Viral hepatitis C is an important global health problem that affects about 2.2% of humans. Strategies on the control of this hepatotropic virus focused on chemotherapy and surveillance of emerging HCV drug resistant mutants, respectively. HCV genotype 1 response to therapy is one of major interests. The aim of this research was to study the prevalence of resistant associated variants (RAVs) in the naïve HCV patient candidate for direct acting antiviral (DAA) therapy. METHODS: A total of 70 HCV confirmed patients which referred to hospitals affiliated to Iran University of Medial Sciences, Tehran, Iran from May 2014 to March 2015 were enrolled in this cross sectional study...
February 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28155030/compositional-analysis-of-topsoil-metals-and-its-associations-with-cancer-mortality-using-spatial-misaligned-data
#11
Gonzalo López-Abente, Juan Locutura-Rupérez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Olivier Núñez
The presence of toxic metals in soil per se, and in soil impacted by mining, industry, agriculture and urbanisation in particular, is a major concern for both human health and ecotoxicology. The dual aim of this study was: to ascertain whether topsoil composition could influence the spatial distribution of mortality due to different types of cancer and to identify possible errors committed by epidemiological studies which analyse soil composition data as a closed number system. We conducted an ecological cancer mortality study, covering 861,440 cancer deaths (27 cancer sites) in 7917 Spanish mainland towns, from 1999 to 2008...
February 2, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28150939/antinociceptive-effects-of-a-novel-%C3%AE-2-%C3%AE-3-subtype-selective-gabaa-receptor-positive-allosteric-modulator
#12
Lakeisha A Lewter, Janet L Fisher, Justin N Siemian, Kashi Reddy Methuku, Michael M Poe, James M Cook, Jun-Xu Li
Pain remains a challenging clinical condition and spinal GABAA receptors are crucial modulators of pain processing. α2/α3-subtype GABAA receptors mediate the analgesic actions of benzodiazepines. Positive allosteric modulators (PAMs) at α2/α3-subtype GABAA receptors may have analgesic potential. Here we report a new selective α2/α3-subtype GABAA receptor PAM in in vitro and in vivo pain assays. KRM-II-81 demonstrated similar efficacy at α1/α2/α3 GABAA receptors and negligible efficacy at α4/α5/α6 GABAA receptors, with α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits...
February 2, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28149693/effects-of-groundwater-abstraction-on-two-keystone-tree-species-in-an-arid-savanna-national-park
#13
Eleanor Shadwell, Edmund February
BACKGROUND: In arid systems with no surface water, deep boreholes in ephemeral river beds provide for humans and animals. With continually increasing infrastructure development for tourism in arid wildlife parks such as the Kgalagadi Transfrontier Park in southern Africa, we ask what effects increased abstraction may have on large trees. Large trees in arid savannas perform essential ecosystem services by providing food, shade, nesting sites and increased nutrients for many other plant and animal species and for this are regarded as keystone species...
2017: PeerJ
https://www.readbyqxmd.com/read/28148748/variability-in-individual-assessment-behaviour-and-its-implications-for-collective-decision-making
#14
Thomas A O'Shea-Wheller, Naoki Masuda, Ana B Sendova-Franks, Nigel R Franks
Self-organized systems of collective behaviour have been demonstrated in a number of group-living organisms. There is, however, less research relating to how variation in individual assessments may facilitate group decision-making. Here, we investigate this using the decentralized system of collective nest choice behaviour employed by the ant Temnothorax albipennis, combining experimental results with computational modelling. In experiments, isolated workers of this species were allowed to investigate new nest sites of differing quality, and it was found that for any given nest quality, there was wide variation among individuals in the durations that they spent within each nest site...
February 8, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28141964/spatial-self-organization-of-ecosystems-integrating-multiple-mechanisms-of-regular-pattern-formation
#15
Robert M Pringle, Corina E Tarnita
Large-scale regular vegetation patterns are common in nature, but their causes are disputed. Whereas recent theory focuses on scale-dependent feedbacks as a potentially universal mechanism, earlier studies suggest that many regular spatial patterns result from territorial interference competition between colonies of social-insect ecosystem engineers, leading to hexagonally overdispersed nest sites and associated vegetation. Evidence for this latter mechanism is scattered throughout decades of disparate literature and lacks a unified conceptual framework, fueling skepticism about its generality in debates over the origins of patterned landscapes...
January 31, 2017: Annual Review of Entomology
https://www.readbyqxmd.com/read/28138379/non-invasive-methods-to-diagnose-fungal-infections-in-pediatric-patients-with-hematologic-disorders
#16
Parisa Badiee, Zahra Hashemizadeh, Mani Ramzi, Mohammad Karimi, Rasoul Mohammadi
BACKGROUND: Invasive fungal infection (IFIs) is a major infectious complication in immunocompromised patients. Early diagnosis and initiation of antifungal therapy is important to achieve the best outcome. OBJECTIVES: The current study aimed to investigate the incidence of IFIs and evaluate the diagnostic performance of non-invasive laboratory tests: serologic (β-D-glucan, galactomannan) and molecular (nested polymerase chain reaction) tests to diagnose fungal infections in hematologic pediatric patients...
November 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/28135666/the-combined-effects-of-a-monotonous-diet-and-exposure-to-thiamethoxam-on-the-performance-of-bumblebee-micro-colonies
#17
C Dance, C Botías, D Goulson
There is a pressing need to better understand the factors contributing to declines of wild pollinators such as bumblebees. Many different contributors have been postulated including: loss of flower-rich habitats and nesting sites; monotonous diets; impacts of invasive pathogens; exposure to pesticides such as neonicotinoids. Past research has tended to investigate the impacts of these stressors in isolation, despite the increasing recognition that bees are simultaneously exposed to a combination of stressors, with potentially additive or synergistic effects...
January 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28133395/linking-loggerhead-locations-using-multiple-methods-to-determine-the-origin-of-sea-turtles-in-feeding-grounds
#18
ALan F Rees, Carlos Carreras, Annette C Broderick, Dimitris Margaritoulis, Thomas B Stringell, Brendan J Godley
Many marine megavertebrate taxa, including sea turtles, disperse widely from their hatching or birthing locations but display natal homing as adults. We used flipper tagging, satellite tracking and genetics to identify the origin of loggerhead turtles living in Amvrakikos Gulf, Greece. This location has been identified as hosting regionally important numbers of large-juvenile to adult sized turtles that display long-term residency and/or association to the area, and also presents a male biased sex ratio for adults...
2017: Marine Biology
https://www.readbyqxmd.com/read/28132106/reproductive-consequences-of-farmland-heterogeneity-in-little-owls-athene-noctua
#19
Vanja T Michel, Beat Naef-Daenzer, Herbert Keil, Martin U Grüebler
The amount of high-quality habitat patches, their distribution, and the resource accessibility therein play a key role in regulating habitat effects on reproductive success. Heterogeneous habitats offer non-substitutable resources (e.g. nest sites and food) and substitutable resources (e.g. different types of food) in close proximity, thereby facilitating landscape complementation and supplementation. However, it remains poorly understood how spatial resource separation in homogeneous agricultural landscapes affects reproductive success...
January 28, 2017: Oecologia
https://www.readbyqxmd.com/read/28131471/pm2-5-in-the-yangtze-river-delta-china-chemical-compositions-seasonal-variations-and-regional-pollution-events
#20
Lili Ming, Ling Jin, Jun Li, Pingqing Fu, Wenyi Yang, Di Liu, Gan Zhang, Zifa Wang, Xiangdong Li
Fine particle (PM2.5) samples were collected simultaneously at three urban sites (Shanghai, Nanjing, and Hangzhou) and one rural site near Ningbo in the Yangtze River Delta (YRD) region, China, on a weekly basis from September 2013 to August 2014. In addition, high-frequency daily sampling was conducted in Shanghai and Nanjing for one month during each season. Severe regional PM2.5 pollution episodes were frequently observed in the YRD, with annual mean concentrations of 94.6 ± 55.9, 97.8 ± 40.5, 134 ± 54...
January 25, 2017: Environmental Pollution
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