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neutrophil stiffness

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https://www.readbyqxmd.com/read/28942364/toll-like-receptor-mediated-upregulation-of-cxcl16-in-psoriasis-orchestrates-neutrophil-activation
#1
Sabine Steffen, Susanne Abraham, Maik Herbig, Franziska Schmidt, Kristin Blau, Susann Meisterfeld, Stefan Beissert, Jochen Guck, Claudia Günther
Innate immune processes are central in the development of the chronic inflammatory skin disease psoriasis. Studying stimulation of keratinocytes, monocytes and dendritic cells by type I interferons or ligation of toll-like receptors TLR1/2, TLR2/6 or TLR7, but not TLR7/8, resulted in enhanced surface expression and secretion of the chemokine CXCL16. The corresponding receptor CXCR6 was expressed on neutrophils whose recruitment into skin is important especially in early psoriatic disease. Using the recently developed technique real-time deformability cytometry demonstrated that CXCL16 and IL-8 decreased the stiffness and enhanced deformation of neutrophils facilitating transmigration through vessel wall...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28912780/inflammatory-markers-for-arterial-stiffness-in-cardiovascular-diseases
#2
REVIEW
Ioana Mozos, Clemens Malainer, Jarosław Horbańczuk, Cristina Gug, Dana Stoian, Constantin Tudor Luca, Atanas G Atanasov
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28813773/a-case-of-ivig-induced-aseptic-chemical-meningitis
#3
Anish Patel, Kalyan Chakravarthy Potu, Tamera Sturm
Intravenous immunoglobulin (IVIG) is a commonly used and generally well-tolerated medication. Common side effects include flu-like symptoms such as fevers, headaches, myalgia, fatigue, and nausea. One of the more rare side effects is aseptic meningitis, with a reported incidence rate of around 0.067 percent of all IVIG infusions. In this paper, we describe a 47-year-old female patient with a history of myasthenia gravis who presented with a headache, neck pain, and neck stiffness while undergoing IVIG infusions for a myasthenia crisis...
March 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28794106/flow-mediated-dilation-and-peripheral-arterial-tonometry-are-disturbed-in-pre-eclampsia-and-reflect-different-aspects-of-endothelial-function
#4
Dominique Mannaerts, Ellen Faes, Inge Goovaerts, Tibor Stoop, Jerome Cornette, Wilfried Jozef Gyselaers, Marc E A Spaanderman, Emeline M Van Craenenbroeck, Yves Jacquemyn
BACKGROUND: Endothelial function and arterial stiffness are known to be altered in pre-eclamptic pregnancies. Previous studies have shown conflicting results regarding the best technique for assessing vascular function in pregnancy. In this study, we made a comprehensive evaluation of in vivo vascular function (including flow-mediated dilatation (FMD), peripheral arterial tonometry (PAT), and arterial stiffness) in pre-eclamptic patients and compared them to normal pregnancies. In addition, we assessed the relation between vascular function and systemic inflammation...
August 9, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28649402/evolutionary-adaptations-of-biofilms-infecting-cystic-fibrosis-lungs-promote-mechanical-toughness-by-adjusting-polysaccharide-production
#5
Kristin Kovach, Megan Davis-Fields, Yasuhiko Irie, Kanishk Jain, Shashvat Doorwar, Katherine Vuong, Numa Dhamani, Kishore Mohanty, Ahmed Touhami, Vernita D Gordon
Biofilms are communities of microbes embedded in a matrix of extracellular polymeric substances, largely polysaccharides. Multiple types of extracellular polymeric substances can be produced by a single bacterial strain. The distinct polymer components of biofilms are known to provide chemical protection, but little is known about how distinct extracellular polysaccharides may also protect biofilms against mechanical stresses such as shear or phagocytic engulfment. Decades-long infections of Pseudomonas. aeruginosa biofilms in the lungs of cystic fibrosis patients are natural models for studies of biofilm fitness under pressure from antibiotics and the immune system...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28601234/comparison-of-echocardiographic-findings-in-patients-with-nonfunctioning-adrenal-incidentalomas
#6
Narin Nasıroglu Imga, Ozgul Ucar Elalmıs, Mazhar Muslum Tuna, Bercem Aycıcek Dogan, Deniz Sahın, Tugba Gursoy, Yavuz Yalcın, Dilek Berker, Serdar Guler
Adrenal incidentalomas (AIs) are usually discovered incidentally after imaging unrelated to adrenal glands. We aimed to evaluate standard risk factors for systemic atherosclerosis and echocardiographic changes in patients with nonfunctioning AIs and compare them with normal subjects. We evaluated 70 patients diagnosed with AIs and 51 healthy controls. Mean levels were determined for HbA1c, LDL, uric acid, fasting plasma insulin, HOMA, and neutrophil-to-lymphocyte ratio (NLR), and these values were found to be significantly higher in the patients than the controls...
June 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28592301/pneumococcal-meningitis-with-normal-cerebrospinal-biochemistry-and-no-pneumococci-at-microscopy-mimicking-a-stroke-a-case-report
#7
Gideon Ertner, Jeppe Romme Christensen, Christian T Brandt
BACKGROUND: Bacterial meningitis commonly presents with symptoms such as headache, impaired consciousness, neck stiffness, and fever. In most cases, cerebrospinal fluid analysis will yield white cell counts >100/mm(3). Atypical presentations occur, especially in the very young or very elderly and the immunocompromised. We report an unusual case of pneumococcal meningitis in a healthy 78-year-old Danish woman who presented with clinical features mimicking a stroke with normal cerebrospinal fluid parameters and without microscopic evidence of bacteria...
June 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28480636/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-artery-stiffness-in-subtypes-of-hypertension
#8
Huan Wang, Yuanhui Hu, Yanting Geng, Huaqin Wu, Yuguang Chu, Ruihua Liu, Yi Wei, Zhiling Qiu
Recently, neutrophil/lymphocyte ratio (NLR) has been proved to be a useful indicator of inflammation and cardiovascular risk. Brachial-ankle pulse wave velocity is an indicator for early atherosclerotic changes. It is unknown whether NLR differs in subtypes of hypertension, and little research has been performed on the relationship between NLR and arteriosclerosis in subtypes of hypertension. The purpose of this article was to investigate their relationship. A total of 217 consecutive patients with hypertension and 132 persons without hypertension were included...
August 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28323056/fty720-promotes-pulmonary-fibrosis-when-administered-during-the-remodelling-phase-following-a-bleomycin-induced-lung-injury
#9
David R Gendron, Anne-Marie Lemay, Pascale Blais Lecours, Valérie Perreault-Vallières, Carole-Ann Huppé, Ynuk Bossé, Marie-Renée Blanchet, Geneviève Dion, David Marsolais
Fibrosis complicates numerous pathologies including interstitial lung diseases. Sphingosine analogs such as FTY720 can alleviate lung injury-induced fibrosis in murine models. Contradictorily, FTY720 also promotes in vitro processes normally leading to fibrosis and high doses in vivo foster lung fibrosis by enhancing vascular leakage into the lung. The goal of this study was to determine the effect of low doses of FTY720 on lung fibrosis triggered by an acute injury in mice. We first defined the time-boundaries delimiting the inflammatory and remodelling phases of an injury elicited by bleomycin based on neutrophil counts, total lung capacity and lung stiffness...
June 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28168136/palisaded-granulomatous-dermatitis-associated-with-ulcerative-colitis-a-comprehensive-literature-review
#10
REVIEW
Katherine M Stiff, Philip R Cohen
Palisaded granulomatous dermatitis is an uncommon pathologic condition potentially associated with several disorders. These include drugs, inflammatory bowel disease, multiple myelomas, rheumatoid arthritis, and systemic lupus erythematosus. An illustrative case of a man with palisaded granulomatous dermatitis who subsequently developed ulcerative colitis is described, and the characteristics of other individuals with ulcerative colitis-associated palisaded granulomatous dermatitis are reviewed. PubMed was used to search the following terms: palisaded, interstitial, granulomatous, dermatitis, ulcerative colitis, and neutrophilic...
January 6, 2017: Curēus
https://www.readbyqxmd.com/read/28092664/expression-of-specific-inflammasome-gene-modules-stratifies-older-individuals-into-two-extreme-clinical-and-immunological-states
#11
David Furman, Junlei Chang, Lydia Lartigue, Christopher R Bolen, François Haddad, Brice Gaudilliere, Edward A Ganio, Gabriela K Fragiadakis, Matthew H Spitzer, Isabelle Douchet, Sophie Daburon, Jean-François Moreau, Garry P Nolan, Patrick Blanco, Julie Déchanet-Merville, Cornelia L Dekker, Vladimir Jojic, Calvin J Kuo, Mark M Davis, Benjamin Faustin
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the maturation of interleukin-1β (IL-1β). Here we find that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expression of IL-1β, who lack these characteristics...
February 2017: Nature Medicine
https://www.readbyqxmd.com/read/28062999/relationship-between-increased-carotid-artery-stiffness-and-idiopathic-subjective-tinnitus
#12
C Bayraktar, S Taşolar
Tinnitus is defined as perception of sound with no external stimulus, and can separate into pulsatile and non-pulsatile types. Arterial stiffness is a parameter that can predict the cardiovascular event and associated with incidence of stroke. It has been shown that increased arterial stiffness may lead to microvascular damage in brain. Our aim was to assess the arterial stiffness of the carotid system in the development and severity of idiopathic subjective tinnitus. Forty subjective tinnitus patients and 40 age- and sex-matched controls were enrolled in the study...
May 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27940753/a-5-year-old-with-fever-headache-neck-stiffness-and-leg-pain
#13
Joy Solano, Grace Winningham, Duha Al Zubeidi, Angela Myers
A 5-year-old boy presented with fever, headache, fatigue, neck stiffness, and 2 episodes of nocturnal urinary incontinence, prompting a visit to the emergency department. He had experienced intermittent frontal headaches and leg and buttock pain for several months, which had worsened over the previous 2 weeks. His history was notable for a spinal hemangioma with vascular tract, but he was otherwise healthy. On examination, he was febrile and tachycardic. He held his neck slightly rotated to the right with limited range of motion in all directions due to pain...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27881094/neutrophil-lymphocyte-ratio-is-associated-with-arterial-stiffness-in-patients-with-peritoneal-dialysis
#14
Kedan Cai, Qun Luo, Beixia Zhu, Lina Han, Dan Wu, Zhiwei Dai, Kaiyue Wang
BACKGROUND: Patients with peritoneal dialysis are in the persistent inflammation state and have elevated arterial stiffness. Neutrophil-lymphocyte ratio(NLR) is a new inflammatory marker in renal and cardiac disorders. Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measurement, which is widely used as a surrogate marker of arterial stiffness. However, there is little evidence to show an association between NLR and baPWV in patients with peritoneal dialysis. The aim of this cross-section study was to investigate the relationship between NLR and arterial stiffness measured by baPWV in patients with peritoneal dialysis...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27689735/baricitinib-in-patients-with-inadequate-response-or-intolerance-to-conventional-synthetic-dmards-results-from-the-ra-build-study
#15
RANDOMIZED CONTROLLED TRIAL
Maxime Dougados, Désirée van der Heijde, Ying-Chou Chen, Maria Greenwald, Edit Drescher, Jiajun Liu, Scott Beattie, Sarah Witt, Inmaculada de la Torre, Carol Gaich, Terence Rooney, Douglas Schlichting, Stephanie de Bono, Paul Emery
BACKGROUND: Baricitinib is an oral, reversible, selective Janus kinase 1 and 2 inhibitor. METHODS: In this phase III, double-blind 24-week study, 684 biologic disease-modifying antirheumatic drug (DMARD)-naïve patients with rheumatoid arthritis and inadequate response or intolerance to ≥1 conventional synthetic DMARDs were randomly assigned 1:1:1 to placebo or baricitinib (2 or 4 mg) once daily, stratified by region and the presence of joint erosions. Endpoint measures included American College of Rheumatology 20% response (ACR20, primary endpoint), Disease Activity Score (DAS28) and Simplified Disease Activity Index (SDAI) score ≤3...
January 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27508669/-op-3d-03-association-between-neutrophil-to-lymphocyte-ratio-and-arterial-stiffness-in-a-population-sample
#16
E Huguet, G Maccallini, P Pardini, S Obregon, M Hidalgo, M Haehnel, P Carrizo, M Koretzky, A Di Leva, F Inserra, F Botto, A Scuteri, P M Nilsson, C Kotliar
OBJECTIVE: Immuno-inflammation plays a key role in the process of atherosclerosis and vascular stiffness as surrogates for Early Vascular Ageing (EVA). Our aim was to evaluate the association between the Neutrophil to Lymphocyte Ratio (NLR), a validated inflammatory marker, and arterial stiffness represented by the pulse wave velocity (PWV), in a population-based sample. DESIGN AND METHOD: We included prospectively 237 adults who attended for cardiovascular screening tests...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27488756/investigation-of-the-arterial-stiffness-and-associated-factors-in-patients-with-familial-mediterranean-fever
#17
Mustafa Çakar, Muharrem Akhan, Tolga Doğan, Gürhan Taşkın, Kadir Öztürk, Muhammet Çınar, Erol Arslan, Sedat Yılmaz
OBJECTIVE: Because of the ongoing and recurring inflammatory state in familial Mediterranean fever (FMF), patients may experience a high risk of cardiovascular events. Our aim was to investigate the arterial stiffness and associated factors in patients with FMF. METHODS: Sixty-nine consecutive FMF patients (including 11 females) and 35 controls (including 5 females) were enrolled in the study. The demographical, clinical, and laboratory data and genetic mutations of the patients were recorded...
February 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27433796/early-biomarkers-of-renal-damage-in-relation-to-arterial-stiffness-and-inflammation-in-male-coronary-artery-disease-patients
#18
Kaido Paapstel, Mihkel Zilmer, Jaan Eha, Kaspar Tootsi, Anneli Piir, Jaak Kals
BACKGROUND/AIMS: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27389524/first-report-and-histological-features-of-chlamydia-pecorum-encephalitis-in-calves-in-new-zealand
#19
H Hunt, Gmb Orbell, K N Buckle, H J Ha, K E Lawrence, R A Fairley, J S Munday
CASE HISTORY: Between September and October 2013, 40 of 150 crossbred Friesian dairy calves on a farm in the Manawatu region of New Zealand developed neurological signs when between 1 and 3 months of age. Calves were grazed in multiple mobs and calves from each mob were affected. A variable response was observed to initial treatment with thiamine, fluoroquinolone antibiotics and non-steroidal anti-inflammatory drugs. CLINICAL AND PATHOLOGICAL FINDINGS: Affected calves exhibited a range of neurological signs that included generalised depression, hind limb ataxia with a stiff gait, and knuckling of the fetlocks...
November 2016: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/27327172/retrospective-evaluation-of-horses-diagnosed-with-neuroborreliosis-on-postmortem-examination-16-cases-2004-2015
#20
L K Johnstone, J B Engiles, H Aceto, V Buechner-Maxwell, T Divers, R Gardner, R Levine, N Scherrer, D Tewari, J Tomlinson, A L Johnson
BACKGROUND: Equine neuroborreliosis (NB), Lyme disease, is difficult to diagnose and has limited description in the literature. OBJECTIVE: Provide a detailed description of clinical signs, diagnostic, and pathologic findings of horses with NB. ANIMALS: Sixteen horses with histologically confirmed NB. METHODS: Retrospective review of medical records at the University of Pennsylvania and via an ACVIM listserv query with inclusion criteria requiring possible exposure to Borrelia burgdorferi and histologic findings consistent with previous reports of NB without evidence of other disease...
July 2016: Journal of Veterinary Internal Medicine
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