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neutrophil stiffness

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https://www.readbyqxmd.com/read/27881094/neutrophil-lymphocyte-ratio-is-associated-with-arterial-stiffness-in-patients-with-peritoneal-dialysis
#1
Kedan Cai, Qun Luo, Beixia Zhu, Lina Han, Dan Wu, Zhiwei Dai, Kaiyue Wang
BACKGROUND: Patients with peritoneal dialysis are in the persistent inflammation state and have elevated arterial stiffness. Neutrophil-lymphocyte ratio(NLR) is a new inflammatory marker in renal and cardiac disorders. Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measurement, which is widely used as a surrogate marker of arterial stiffness. However, there is little evidence to show an association between NLR and baPWV in patients with peritoneal dialysis. The aim of this cross-section study was to investigate the relationship between NLR and arterial stiffness measured by baPWV in patients with peritoneal dialysis...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27689735/baricitinib-in-patients-with-inadequate-response-or-intolerance-to-conventional-synthetic-dmards-results-from-the-ra-build-study
#2
Maxime Dougados, Désirée van der Heijde, Ying-Chou Chen, Maria Greenwald, Edit Drescher, Jiajun Liu, Scott Beattie, Sarah Witt, Inmaculada de la Torre, Carol Gaich, Terence Rooney, Douglas Schlichting, Stephanie de Bono, Paul Emery
BACKGROUND: Baricitinib is an oral, reversible, selective Janus kinase 1 and 2 inhibitor. METHODS: In this phase III, double-blind 24-week study, 684 biologic disease-modifying antirheumatic drug (DMARD)-naïve patients with rheumatoid arthritis and inadequate response or intolerance to ≥1 conventional synthetic DMARDs were randomly assigned 1:1:1 to placebo or baricitinib (2 or 4 mg) once daily, stratified by region and the presence of joint erosions. Endpoint measures included American College of Rheumatology 20% response (ACR20, primary endpoint), Disease Activity Score (DAS28) and Simplified Disease Activity Index (SDAI) score ≤3...
September 29, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27508669/-op-3d-03-association-between-neutrophil-to-lymphocyte-ratio-and-arterial-stiffness-in-a-population-sample
#3
E Huguet, G Maccallini, P Pardini, S Obregon, M Hidalgo, M Haehnel, P Carrizo, M Koretzky, A Di Leva, F Inserra, F Botto, A Scuteri, P M Nilsson, C Kotliar
OBJECTIVE: Immuno-inflammation plays a key role in the process of atherosclerosis and vascular stiffness as surrogates for Early Vascular Ageing (EVA). Our aim was to evaluate the association between the Neutrophil to Lymphocyte Ratio (NLR), a validated inflammatory marker, and arterial stiffness represented by the pulse wave velocity (PWV), in a population-based sample. DESIGN AND METHOD: We included prospectively 237 adults who attended for cardiovascular screening tests...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27488756/investigation-of-the-arterial-stiffness-and-associated-factors-in-patients-with-familial-mediterranean-fever
#4
Mustafa Çakar, Muharrem Akhan, Tolga Doğan, Gürhan Taşkın, Kadir Öztürk, Muhammet Çınar, Erol Arslan, Sedat Yılmaz
OBJECTIVE: Because of the ongoing and recurring inflammatory state in familial Mediterranean fever (FMF), patients may experience a high risk of cardiovascular events. Our aim was to investigate the arterial stiffness and associated factors in patients with FMF. METHODS: Sixty-nine consecutive FMF patients (including 11 females) and 35 controls (including 5 females) were enrolled in the study. The demographical, clinical, and laboratory data and genetic mutations of the patients were recorded...
July 21, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27433796/early-biomarkers-of-renal-damage-in-relation-to-arterial-stiffness-and-inflammation-in-male-coronary-artery-disease-patients
#5
Kaido Paapstel, Mihkel Zilmer, Jaan Eha, Kaspar Tootsi, Anneli Piir, Jaak Kals
BACKGROUND/AIMS: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27389524/first-report-and-histological-features-of-chlamydia-pecorum-encephalitis-in-calves-in-new-zealand
#6
H Hunt, Gmb Orbell, K N Buckle, H J Ha, K E Lawrence, R A Fairley, J S Munday
CASE HISTORY: Between September and October 2013, 40 of 150 crossbred Friesian dairy calves on a farm in the Manawatu region of New Zealand developed neurological signs when between 1 and 3 months of age. Calves were grazed in multiple mobs and calves from each mob were affected. A variable response was observed to initial treatment with thiamine, fluoroquinolone antibiotics and non-steroidal anti-inflammatory drugs. CLINICAL AND PATHOLOGICAL FINDINGS: Affected calves exhibited a range of neurological signs that included generalised depression, hind limb ataxia with a stiff gait, and knuckling of the fetlocks...
November 2016: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/27327172/retrospective-evaluation-of-horses-diagnosed-with-neuroborreliosis-on-postmortem-examination-16-cases-2004-2015
#7
L K Johnstone, J B Engiles, H Aceto, V Buechner-Maxwell, T Divers, R Gardner, R Levine, N Scherrer, D Tewari, J Tomlinson, A L Johnson
BACKGROUND: Equine neuroborreliosis (NB), Lyme disease, is difficult to diagnose and has limited description in the literature. OBJECTIVE: Provide a detailed description of clinical signs, diagnostic, and pathologic findings of horses with NB. ANIMALS: Sixteen horses with histologically confirmed NB. METHODS: Retrospective review of medical records at the University of Pennsylvania and via an ACVIM listserv query with inclusion criteria requiring possible exposure to Borrelia burgdorferi and histologic findings consistent with previous reports of NB without evidence of other disease...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27308888/detection-and-dna-quantification-of-enterococcus-casseliflavus-in-a-foal-with-septic-meningitis
#8
Valentina Stefanetti, Francesca Beccati, Fabrizio Passamonti, Elisa Sgariglia, Mauro Coletti, Matteo Vuerich, Maria Luisa Marenzoni
CASE DESCRIPTION A 3-month-old 180-kg (396-lb) Hanoverian colt was examined because of fever, lethargy, inappetence, drooping of the left ear, and stiff neck posture. Initial treatment included empirical antimicrobial treatment and NSAIDs. CLINICAL FINDINGS Initial findings were consistent with CNS anomalies. Endoscopy revealed hyperemia, ecchymosis, and some mucopurulent exudate in the right guttural pouch. Hematologic findings were consistent with neutrophilic inflammation. On the third day of hospitalization, severe neurologic signs were observed...
July 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27163941/computational-cell-analysis-for-label-free-detection-of-cell-properties-in-a-microfluidic-laminar-flow
#9
Alex Ce Zhang, Yi Gu, Yuanyuan Han, Zhe Mei, Yu-Jui Chiu, Lina Geng, Sung Hwan Cho, Yu-Hwa Lo
Although a flow cytometer, being one of the most popular research and clinical tools for biomedicine, can analyze cells based on the cell size, internal structures such as granularity, and molecular markers, it provides little information about the physical properties of cells such as cell stiffness and physical interactions between the cell membrane and fluid. In this paper, we propose a computational cell analysis technique using cells' different equilibrium positions in a laminar flow. This method utilizes a spatial coding technique to acquire the spatial position of the cell in a microfluidic channel and then uses mathematical algorithms to calculate the ratio of cell mixtures...
June 20, 2016: Analyst
https://www.readbyqxmd.com/read/27159286/effect-of-a-simple-collagen-type-i-sponge-for-achilles-tendon-repair-in-a-rat-model
#10
Sebastian A Müller, Lutz Dürselen, Patricia Heisterbach, Chris Evans, Martin Majewski
BACKGROUND: Several sophisticated approaches to tendon engineering have been investigated as ways to improve tendon healing with the early formation of repair tissue with possibly a high amount of type I collagen. Besides the new formation of collagen type I, there is evidence for the natural integration of surrounding collagen type I from healthy tendon parts into the healing defect. However, the simple application of a type I collagen sponge to the healing site to increase the amount of local collagen type I has not been investigated...
August 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27073429/neuro-sweet-disease-with-positive-modified-acid-fast-staining-of-the-cerebrospinal-fluid-a-case-report
#11
Juan-Fang Liu, Yuan Li, Kai Li, Xiao Zhang, Yi-Ning Yang, Gang Zhao, Zhi-Rong Liu
Neuro-Sweet disease (NSD) is Sweet disease with central nervous system (CNS) involvement. To the best of our knowledge, the present case report is the first to describe NSD complicated by endogenous infection with Mycobacterium tuberculosis. The present case report describes a male patient who developed NSD-induced meningitis, which initially manifested as a fever, headache and neck stiffness. Painful erythematous plaques subsequently developed on his face, neck and upper trunk. Brain magnetic resonance imaging was performed and the results were normal, whereas modified acid-fast stain analysis of the cerebrospinal fluid (CSF) provided a positive result...
April 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27014355/assessment-of-aortic-elasticity-in-patients-with-celiac-disease
#12
Nermin Bayar, Ayhan Hilmi Çekin, Şakir Arslan, Göksel Çağırcı, Selçuk Küçükseymen, Serkan Çay, Ferda Akbay Harmandar, Bayram Yeşil
BACKGROUND AND OBJECTIVES: Celiac disease (CD) is a chronic autoimmune disorder induced by dietary gluten intake by individuals who are genetically sensitive. Many studies report an increased risk of cardiovascular diseases in such patients. The aim of this study is to assess aortic elasticity properties in patients with CD that may be associated with an increased risk of cardiovascular disease. SUBJECTS AND METHODS: Eighty-one patients diagnosed with CD by antibody test and biopsy and 63 healthy volunteers were included in this prospective study...
March 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27010150/early-and-late-aortic-propagation-velocity-values-in-stemi-patients-after-successful-primary-pci-and-their-relationship-with-neutrophil-to-lymphocyte-ratio
#13
M Yaman, U Arslan, O Beton, H E Pamukcu, O Dogdu
OBJECTIVE: Atherosclerosis leads to increased arterial resistance through thickening and stiffening of the arterial wall, a phenomenon largely known as arterial stiffness. M-mode propagation velocity of the descending thoracic aorta, named aortic velocity propagation (AVP) is a novel method for the measurement of the aortic stiffness. We aimed to investigate the difference between early and late values of AVP after successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients...
March 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26958891/endothelial-surface-protrusion-by-a-point-force
#14
Yong Chen, Lan Lu, Jin-Yu Shao
During leukocyte rolling on the endothelium, surface protrusion and membrane tether extraction occur consecutively on leukocytes. Both surface protrusion and tether extraction of leukocytes stabilize leukocyte rolling. Tethers can also be extracted from endothelial cells (ECs), but surface protrusion of ECs has never been confirmed to exist. In this study, we examined EC surface protrusion with the micropipette aspiration technique. We found that, like leukocytes, surface protrusion on an EC did exist when a point force was imposed...
March 8, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/26929377/mean-deformation-metrics-for-quantifying-3d-cell-matrix-interactions-without-requiring-information-about-matrix-material-properties
#15
David A Stout, Eyal Bar-Kochba, Jonathan B Estrada, Jennet Toyjanova, Haneesh Kesari, Jonathan S Reichner, Christian Franck
Mechanobiology relates cellular processes to mechanical signals, such as determining the effect of variations in matrix stiffness with cell tractions. Cell traction recorded via traction force microscopy (TFM) commonly takes place on materials such as polyacrylamide- and polyethylene glycol-based gels. Such experiments remain limited in physiological relevance because cells natively migrate within complex tissue microenvironments that are spatially heterogeneous and hierarchical. Yet, TFM requires determination of the matrix constitutive law (stress-strain relationship), which is not always readily available...
March 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26871812/platelet-to-lymphocyte-percentage-ratio-is-associated-with-brachial-ankle-pulse-wave-velocity-in-hemodialysis
#16
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, Yi-Chun Tsai, Hsiu-Chin Mai, Ho-Ming Su, Jer-Ming Chang, Hung-Chun Chen
Increased arterial stiffness in patients receiving hemodialysis (HD) is highly prevalent and is associated with cardiovascular morbidity and mortality. In HD, inflammation is one of the major causes of increased arterial stiffness. Activation of platelets and decreased lymphocyte percentage (LYMPH%) may exhibit inflammation. The aim of this study is to examine the relationship between platelet to LYMPH% ratio and arterial stiffness in HD patients.A total of 220 patients receiving HD were enrolled in this study...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26858715/macrophage-migration-inhibitory-factor-in-clinical-kidney-disease
#17
REVIEW
Annette Bruchfeld, Mårten Wendt, Edmund J Miller
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine implicated in acute and chronic inflammatory conditions, including sepsis, autoimmune disease, atherogenesis, plaque instability, and pulmonary arterial hypertension. MIF in plasma and urine is significantly elevated in patients with acute kidney injury (AKI) and elevated MIF in serum is associated with markers of oxidative stress, endothelial dysfunction, arterial stiffness, and markers of myocardial damage in chronic kidney disease (CKD)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26757701/the-leukocyte-stiffening-property-of-plasma-in-early-acute-respiratory-distress-syndrome-ards-revealed-by-a-microfluidic-single-cell-study-the-role-of-cytokines-and-protection-with-antibodies
#18
Pascal Preira, Jean-Marie Forel, Philippe Robert, Paulin Nègre, Martine Biarnes-Pelicot, Francois Xeridat, Pierre Bongrand, Laurent Papazian, Olivier Theodoly
BACKGROUND: Leukocyte-mediated pulmonary inflammation is a key pathophysiological mechanism involved in acute respiratory distress syndrome (ARDS). Massive sequestration of leukocytes in the pulmonary microvasculature is a major triggering event of the syndrome. We therefore investigated the potential role of leukocyte stiffness and adhesiveness in the sequestration of leukocytes in microvessels. METHODS: This study was based on in vitro microfluidic assays using patient sera...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26601454/three-day-fever
#19
REVIEW
A J Akakpo
Three-day fever is a viral disease caused by an Ephemerovirus of the family Rhabdoviridae, transmitted by arthropod vectors. It is common in tropical and sub-tropical regions, where it affects mainly domestic cattle and buffaloes, especially in intensive dairy or fattening production systems. It is of economic importance because it reduces milk production and fertility and causes abortion. The disease is generally benign. It manifests in several susceptible subjects simultaneously, with a sudden episode of fever accompanied by muscle involvement with arthritis, stiffness of the limbs, and lameness, followed by rapid recovery...
August 2015: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/26367229/a-prospective-investigation-of-cell-dose-in-single-unit-umbilical-cord-blood-transplantation-for-adults-with-high-risk-hematologic-malignancies
#20
U Sobol, A Go, S Kliethermes, S Bufalino, T Rodriguez, S Smith, M Parthasarathy, P Stiff
Umbilical cord blood (UCB) as an allogeneic transplant source is generally limited to units with pre-cryopreservation total nucleated cell (TNC) doses ⩾2.5 × 10(7) NC/kg. We prospectively investigated single UCB transplantation, with cord units as low as 1 × 10(7) NC/kg, all processed with post-thaw albumin-dextran dilution. We transplanted 104 adult patients with 84% having relapsed/refractory disease. The median TNC dose was 2.1 × 10(7) NC/kg (range: 1.0-4.4 × 10(7)) and median CD34+ cell dose was 1...
December 2015: Bone Marrow Transplantation
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