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https://www.readbyqxmd.com/read/29166589/granulocyte-monocyte-progenitors-and-monocyte-dendritic-cell-progenitors-independently-produce-functionally-distinct-monocytes
#1
Alberto Yáñez, Simon G Coetzee, Andre Olsson, David E Muench, Benjamin P Berman, Dennis J Hazelett, Nathan Salomonis, H Leighton Grimes, Helen S Goodridge
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. Both progenitor populations are thought to derive from common myeloid progenitors (CMPs), and a hierarchical relationship (CMP-GMP-MDP-monocyte) is presumed to underlie monocyte differentiation. Here, however, we demonstrate that mouse MDPs arose from CMPs independently of GMPs, and that GMPs and MDPs produced monocytes via similar but distinct monocyte-committed progenitors...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29164154/the-application-of-dextran-sedimentation-as-an-initial-step-in-neutrophil-purification-promotes-their-stimulation-due-to-the-presence-of-monocytes
#2
Alex Quach, Antonio Ferrante
The purification of human neutrophils for in vitro studies is challenging as they are easily activated through ex vivo manipulations. The technique of erythrocyte sedimentation combined with density gradient centrifugation remains widely practiced and was the subject of this study. Since in the sedimentation step the leukocytes are incubated with dextran, we have raised the likelihood that cellular activation would occur with mediator release leading to neutrophil activation. By comparing the activity of neutrophils purified from whole blood by the classical 2-step method of dextran sedimentation followed by low-density Ficoll-Hypaque (1...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29163546/glucose-6-phosphatase-catalytic-subunit-3-g6pc3-deficiency-associated-with-autoinflammatory-complications
#3
Anoop Mistry, Thomas Scambler, David Parry, Mark Wood, Gabriela Barcenas-Morales, Clive Carter, Rainer Doffinger, Sinisa Savic
G6PC3 deficiency typically causes severe congenital neutropenia, associated with susceptibility to infections, cardiac and urogenital abnormalities. However, here we describe two boys of Pakistani origin who were found to have G6PC3 deficiency due to c.130 C>T mutation, but who have clinical phenotypes that are typical for a systemic autoinflammatory syndrome. The index case presented with combination of unexplained fevers, severe mucosal ulcers, abdominal symptoms, and inflammatory arthritis. He eventually fully responded to anti-TNF therapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162908/human-canonical-cd157-bst1-is-an-alternatively-spliced-isoform-masking-a-previously-unidentified-primate-specific-exon-included-in-a-novel-transcript
#4
Enza Ferrero, Nicola Lo Buono, Simona Morone, Rossella Parrotta, Cecilia Mancini, Alfredo Brusco, Alice Giacomino, Stefania Augeri, Antonio Rosal-Vela, Sonia García-Rodríguez, Mercedes Zubiaur, Jaime Sancho, Alessandra Fiorio Pla, Ada Funaro
CD157/Bst1 is a dual-function receptor and β-NAD(+)-metabolizing ectoenzyme of the ADP-ribosyl cyclase family. Expressed in human peripheral blood neutrophils and monocytes, CD157 interacts with extracellular matrix components and regulates leukocyte diapedesis via integrin-mediated signalling in inflammation. CD157 also regulates cell migration and is a marker of adverse prognosis in epithelial ovarian cancer and pleural mesothelioma. One form of CD157 is known to date: the canonical sequence of 318 aa from a 9-exon transcript encoded by BST1 on human chromosome 4...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162709/ehrlichia-chaffeensis-and-its-invasin-etpe-block-reactive-oxygen-species-generation-by-macrophages-in-a-dnase-x-dependent-manner
#5
Omid Teymournejad, Mingqun Lin, Yasuko Rikihisa
The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrlichia uses the C terminus of its surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C), which directly binds the mammalian cell surface receptor glycosylphosphatidylinositol-anchored protein DNase X...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162555/11%C3%AE-hydroxysteroid-dehydrogenase-1-deficiency-alters-brain-energy-metabolism-in-acute-systemic-inflammation
#6
Manu Verma, Tiina M J Kipari, Zhenguang Zhang, Tak Yung Man, Thorsten Forster, Natalie Z M Homer, Jonathan R Seckl, Megan C Holmes, Karen E Chapman
Chronically elevated glucocorticoid levels impair cognition and are pro-inflammatory in the brain. Deficiency or inhibition of 11 β -hydroxysteroid dehydrogenase type-1 (11 β -HSD1), which converts inactive into active glucocorticoids, protects against glucocorticoid-associated chronic stress- or age-related cognitive impairment. Here, we hypothesised that 11 β -HSD1 deficiency attenuates the brain cytokine response to inflammation. Because inflammation is associated with altered energy metabolism, we also examined the effects of 11 β -HSD1 deficiency upon hippocampal energy metabolism...
November 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29162294/early-detection-of-acute-tubulointerstitial-nephritis-in-the-genesis-of-mesoamerican-nephropathy
#7
Rebecca S B Fischer, Chandan Vangala, Luan Truong, Sreedhar Mandayam, Denis Chavarria, Orlando M Granera Llanes, Marcos U Fonseca Laguna, Alvaro Guerra Baez, Felix Garcia, Ramón García-Trabanino, Kristy O Murray
Mesoamerican nephropathy is a devastating disease of unknown etiology that affects mostly young agricultural workers in Central America. An understanding of the mechanism of injury and the early disease process is urgently needed and will aid in identification of the underlying cause and direct treatment and prevention efforts. We sought to describe the renal pathology in Mesoamerican nephropathy at its earliest clinical appearance in prospectively identified acute case patients in Nicaragua. We considered those with elevated (or increased at least 0...
November 18, 2017: Kidney International
https://www.readbyqxmd.com/read/29160223/hematology-and-condition-factor-of-tui-chub-and-fathead-minnow-parasitized-by-nematode-from-upper-klamath-lake-oregon-usa
#8
Maurício L Martins, Marcos Tavares-Dias, Andrew J Janik, Michael L Kent, Gabriela T Jerônimo
This study evaluated the hematological profile and condition factor (Kn) of tui chub Siphateles bicolor and fathead minnow Pimephales promelas and their associations with larvae of Contracaecum sp. infection of the heart. A total of 30 tui chub and 17 fathead minnow were collected from Upper Klamath Lake, Oregon, USA, measured, and weighed and blood was drawn for hematological analysis. Nematode larvae parasitized tui chub with a prevalence of 50% and mean intensity of 1.40, while 11.8% of fathead minnow were parasitized at a mean intensity of 1...
November 21, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29157250/ozone-exposure-is-associated-with-acute-changes-in-inflammation-fibrinolysis-and-endothelial-cell-function-in-coronary-artery-disease-patients
#9
Jaime E Mirowsky, Martha Sue Carraway, Radhika Dhingra, Haiyan Tong, Lucas Neas, David Diaz-Sanchez, Wayne Cascio, Martin Case, James Crooks, Elizabeth R Hauser, Z Elaine Dowdy, William E Kraus, Robert B Devlin
BACKGROUND: Air pollution is a major risk factor for cardiovascular disease, of which ozone is a major contributor. Several studies have found associations between ozone and cardiovascular morbidity, but the results have been inconclusive. We investigated associations between ozone and changes across biological pathways associated with cardiovascular disease. METHODS: Using a panel study design, 13 participants with coronary artery disease were assessed for markers of systemic inflammation, heart rate variability and repolarization, lipids, blood pressure, and endothelial function...
November 21, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29156848/nomograms-for-prognostic-factors-of-spinal-giant-cell-tumor-combining-traditional-clinical-characteristics-with-inflammatory-biomarkers-after-gross-total-resection
#10
Jialin Li, Bo Li, Pingting Zhou, Jian Zhao, Zhipeng Wu, Xinghai Yang, Haifeng Wei, Tianrui Chen, Jianru Xiao
Giant cell tumor (GCT) of bone is a common primary bone tumor, which exhibits local aggressiveness and recurrent potential, especially for the spinal lesion. Increasing evidence indicates that inflammation plays a vital role in tumorigenesis and progression. The prognostic value of inflammatory biomarkers in GCT has not been established. A retrospective analysis was conducted in patients with spinal GCT in Changzheng Hospital Orthopedic Oncological Center (CHOOC) between January 2005 and October 2015 and 129 patients were identified eligible...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156745/predictive-value-of-preoperative-inflammatory-response-biomarkers-for-metabolic-syndrome-and-post-pcnl-systemic-inflammatory-response-syndrome-in-patients-with-nephrolithiasis
#11
Kun Tang, Haoran Liu, Kehua Jiang, Tao Ye, Libin Yan, Peijun Liu, Ding Xia, Zhiqiang Chen, Hua Xu, Zhangqun Ye
Neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) were promising biomarkers used to predict diagnosis and prognosis in various inflammatory responses diseases and cancers. However, there have been no reports regarding these biomarkers in kidney stone patients. This study aimed to evaluate the predictive value of inflammatory biomarkers for metabolic syndrome (MetS) and post-PCNL SIRS in nephrolithiasis patients...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154782/neutrophil-depletion-protects-against-zomepirac-induced-acute-kidney-injury-in-mice
#12
Shohei Yamashita, Shingo Oda, Hideko Endo, Koichi Tsuneyama, Tsuyoshi Yokoi
Acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs have been implicated in drug toxicity. Zomepirac (ZP) is a non-steroidal anti-inflammatory drug that was withdrawn from the market because of anaphylactic reactions and renal injury. We recently established a novel mouse model of ZP-induced kidney injury by increasing zomepirac acyl-glucuronide (ZP-AG) concentration via pretreatment with tri-O-tolyl phosphate, a nonselective esterase inhibitor, and l-buthionine-(S,R)-sulfoximine, a glutathione synthesis inhibitor...
November 14, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29145579/progesterone-the-maternal-immune-system-and-the-onset-of-parturition-in-the-mouse
#13
Lydia F Edey, Hector Georgiou, Kieran P O'Dea, Sam Mesiano, Bronwen R Herbert, Kaiyu Lei, Renyi Hua, Danijela Markovic, Simon N Waddington, David MacIntyre, Philip Bennett, Masao Takata, Mark R Johnson
The role of progesterone (P4) in the regulation of the local (uterine) and systemic innate immune system, myometrial expression of connexin 43 (Cx-43) and cyclooxygenase 2 (COX-2) and the onset of parturition was examined in: 1) naïve mice delivering at term; 2) E16 mice treated with RU486 (P4-antagonist) to induce preterm parturition; and 3) in mice treated with P4 to prevent term parturition.In naïve mice, myometrial neutrophil and monocyte numbers peaked at E18 and declined with the onset of parturition...
November 14, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#14
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29140561/interaction-among-smoking-status-single-nucleotide-polymorphisms-and-markers-of-systemic-inflammation-in-healthy-individuals
#15
Thitiya Luetragoon, Lars Erik Rutqvist, Orathai Tangvarasittichai, Bengt-Åke Andersson, Sture Löfgren, Kanchana Usuwanthim, Nongnit Laytragoon Lewin
Cigarette smoke contains toxic and carcinogenic substances that contribute to the development of cancer and various diseases. Genetic variation might be important because not all smokers develop smoking-related disease. The current study addressed the possible interactions among selected single nucleotide polymorphisms (SNPs) in genes related to systemic inflammation, smoking status, the levels of circulating immune response cells and plasma biomarkers of systemic inflammation. Sixty-four healthy blood donors were recruited, of whom 31 were current smokers and 33 were never-users of tobacco products, references...
November 15, 2017: Immunology
https://www.readbyqxmd.com/read/29137638/virus-triggered-exacerbation-in-allergic-asthmatic-children-neutrophilic-airway-inflammation-and-alteration-of-virus-sensors-characterize-a-subgroup-of-patients
#16
Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq, Philippe Gosset
BACKGROUND: Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function...
November 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29137187/clinical-usefulness-of-the-platelet-to-lymphocyte-ratio-in-patients-with-angiosarcoma-of-the-face-and-scalp
#17
Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Daisuke Shimizu, Takuya Kimoto, Jun Asai, Makoto Wada, Satoshi Komori, Norito Katoh, Kei Yamada
Angiosarcoma of the face and scalp (ASFS) is an extremely aggressive tumor that frequently metastasizes, often leading to death. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are inflammatory markers that predict outcome of various cancers. We aimed to examine the relationship between pretreatment inflammatory markers and ASFS outcome. We included 17 patients with ASFS and a control group of 56 age- and gender-matched healthy individuals...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29134526/mucociliary-transport-differential-white-blood-cells-and-cyto-genotoxicity-in-peripheral-erythrocytes-in-fish-from-a-polluted-urban-pond
#18
Edison Bezerra da Silva, Sandra Aparecida da Silva Corrêa, Denis Moledo de Souza Abessa, Bruno Ferreira Xavier da Silva, Dolores Helena Rodriguez Ferreira Rivero, Robson Seriani
The present study evaluated the water quality of a polluted pond through the analysis of in vitro mucociliary transport, hematological parameters, and biomarkers of cyto-genotoxicity in the Nile tilapia (Oreochromis niloticus). Blood and mucus samples were collected from ten specimens from the polluted pond and from ten specimens from a control area. The fish were anesthetized with 3% benzocaine, mucus was collected directly from the gills, and blood was drawn from the caudal artery. Blood smears were stained using the May-Grünwald Giemsa process for the differential leukocyte counts and to determine the frequency of leukocytes, thrombocytes, erythroblasts, micronuclei, and nuclear abnormalities...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29134377/markers-of-systemic-inflammatory-response-are-prognostic-factors-in-patients-with-pancreatic-neuroendocrine-tumors-pnets-a-prospective-analysis
#19
Apostolos Gaitanidis, Dhaval Patel, Naris Nilubol, Amit Tirosh, Samira Sadowski, Electron Kebebew
BACKGROUND: The prognosis and behavior of pancreatic neuroendocrine tumors (PNETs) vary and may be divergent even at the same stage or tumor grade. Markers of systemic inflammatory response are readily available and are inexpensive, and have been shown to be prognostic factors in several cancers. OBJECTIVE: The aim of this study was to evaluate the prognostic utility of markers of systemic inflammatory response in patients with PNETs. METHODS: A prospective study of 97 patients with PNETs was performed (median follow-up of 15 months, range 12-73 months)...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#20
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
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