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https://www.readbyqxmd.com/read/29329979/how-acute-stress-may-enhance-subsequent-memory-for-threat-stimuli-outside-the-focus-of-attention-dlpfc-amygdala-decoupling
#1
Yu Luo, Guillén Fernández, Erno Hermans, Susanne Vogel, Yu Zhang, Hong Li, Floris Klumpers
Stress-related disorders, e.g., anxiety and depression, are characterized by decreased top-down control for distracting information, as well as a memory bias for threatening information. However, it is unclear how acute stress biases mnemonic encoding and leads to prioritized storage of threat-related information even if outside the focus of attention. In the current study, healthy adults (N = 53, all male) were randomly assigned to stress induction using the socially evaluated cold-pressor test (SECPT) or a control condition...
January 9, 2018: NeuroImage
https://www.readbyqxmd.com/read/29329375/heterogeneous-redistribution-of-facial-subcategory-information-within-and-outside-the-face-selective-domain-in-primate-inferior-temporal-cortex
#2
Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
The inferior temporal cortex (ITC) contains neurons selective to multiple levels of visual categories. However, the mechanisms by which these neurons collectively construct hierarchical category percepts remain unclear. By comparing decoding accuracy with simultaneously acquired electrocorticogram (ECoG), local field potentials (LFPs), and multi-unit activity in the macaque ITC, we show that low-frequency LFPs/ECoG in the early evoked visual response phase contain sufficient coarse category (e.g., face) information, which is homogeneous and enhanced by spatial summation of up to several millimeters...
January 10, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29324073/rapid-improvement-on-a-temporal-attention-task-within-a-single-session-of-high-frequency-transcranial-random-noise-stimulation
#3
Sarah C Tyler, Federica Contò, Lorella Battelli
This study explored the modulatory effects of high-frequency transcranial random noise stimulation (tRNS) on visual sensitivity during a temporal attention task. We measured sensitivity to different onset asynchronies during a temporal order judgment task as a function of active stimulation relative to sham. While completing the task, participants were stimulated bilaterally for 20 min over either the TPJ or the human middle temporal area. We hypothesized that tRNS over the TPJ, which is critical to the temporal attention network, would selectively increase cortical excitability and induce cognitive training-like effects on performance, perhaps more so in the left visual field [Matthews, N...
January 11, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29323239/specific-phospholipids-regulate-the-acquisition-of-neuronal-and-astroglial-identities-in-post-mitotic-cells
#4
Aneley Montaner, Themis Taynah da Silva Santana, Timm Schroeder, Marcelo Einiker-Lamas, Javier Girardini, Marcos Romualdo Costa, Claudia Banchio
Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311338/faulty-neuronal-determination-and-cell-polarization-are-reverted-by-modulating-hd-early-phenotypes
#5
P Conforti, D Besusso, V D Bocchi, A Faedo, E Cesana, G Rossetti, V Ranzani, C N Svendsen, L M Thompson, M Toselli, G Biella, M Pagani, E Cattaneo
Increasing evidence suggests that early neurodevelopmental defects in Huntington's disease (HD) patients could contribute to the later adult neurodegenerative phenotype. Here, by using HD-derived induced pluripotent stem cell lines, we report that early telencephalic induction and late neural identity are affected in cortical and striatal populations. We show that a large CAG expansion causes complete failure of the neuro-ectodermal acquisition, while cells carrying shorter CAGs repeats show gross abnormalities in neural rosette formation as well as disrupted cytoarchitecture in cortical organoids...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29311140/visual-short-term-memory-activity-in-parietal-lobe-reflects-cognitive-processes-beyond-attentional-selection
#6
Summer L Sheremata, David C Somers, Sarah Shomstein
Visual attention and short-term memory (VSTM) are distinct yet inter-related processes. While both require selection of information across the visual field, memory additionally requires maintenance of information across time and distraction. VSTM recruits areas within human (male and female) dorsal and ventral parietal cortex that are also implicated in spatial selection, therefore, it is important to determine if overlapping activation might reflect shared attentional demands. Here, identical stimuli and controlled sustained attention across both tasks were used to ask whether fMRI signal amplitude, functional connectivity, and contralateral visual field bias reflect memory-specific task demands...
January 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29310889/how-hot-are-they-neural-correlates-of-genital-arousal-an-infrared-thermographic-and-functional-magnetic-resonance-imaging-study-of-sexual-arousal-in-men-and-women
#7
Mayte Parada, Marina Gérard, Kevin Larcher, Alain Dagher, Yitzchak M Binik
BACKGROUND: The few studies that have examined the neural correlates of genital arousal have focused on men and are methodologically hard to compare. AIM: To investigate the neural correlates of peripheral physiologic sexual arousal using identical methodology for men and women. METHODS: 2 groups (20 men, 20 women) viewed movie clips (erotic, humor) while genital temperature was continuously measured using infrared thermal imaging. Participants also continuously evaluated changes in their subjective arousal and answered discrete questions about liking the movies and wanting sexual stimulation...
January 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29303470/previously-unreported-complications-associated-with-integrated-cage-screws-following-anterior-lumbar-interbody-fusion-report-of-2-cases
#8
Neginder Saini, Mohammad Zaidi, Maureen T Barry, Robert F Heary
Anterior lumbar interbody fusion (ALIF) is a widely performed surgical treatment for various lumbar spine pathologies. The authors present the first reports of virtually identical cases of complications with integrated screws in stand-alone interbody cages. Two patients presented with the onset of S-1 radiculopathy due to screw misplacements following an ALIF procedure. In both cases, an integrated screw from the cage penetrated the dorsal aspect of the S-1 cortical margin of the vertebra, extended into the neural foramen, and injured the traversing left S-1 nerve roots...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29299322/mechanisms-of-urodele-limb-regeneration
#9
REVIEW
David L Stocum
This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization...
August 2017: Regeneration
https://www.readbyqxmd.com/read/29296476/optical-mapping-of-brain-activation-during-the-english-to-chinese-and-chinese-to-english-sight-translation
#10
Yan He, Meng-Yun Wang, Defeng Li, Zhen Yuan
Translating from Chinese into another language or vice versa is becoming a widespread phenomenon. However, current neuroimaging studies are insufficient to reveal the neural mechanism underlying translation asymmetry during Chinese/English sight translation. In this study, functional near infrared spectroscopy (fNIRS) was used to extract the brain activation patterns associated with Chinese/English sight translation. Eleven unbalanced Chinese (L1)/English (L2) bilinguals participated in this study based on an intra-group experimental design, in which two translation and two reading aloud tasks were administered: forward translation (from L1 to L2), backward translation (from L2 to L1), L1 reading, and L2 reading...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29296000/non-canonical-wnt-signaling-regulates-neural-stem-cell-quiescence-during-homeostasis-and-after-demyelination
#11
Manideep Chavali, Michael Klingener, Alexandros G Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre
Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecular mechanisms that trigger the activation of quiescent NSCs during homeostasis and tissue repair are still unclear. Here, we uncovered that the NSC quiescent state is maintained by Rho-GTPase Cdc42, a downstream target of non-canonical Wnt signaling...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29290550/exploration-disrupts-choice-predictive-signals-and-alters-dynamics-in-prefrontal-cortex
#12
R Becket Ebitz, Eddy Albarran, Tirin Moore
In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions between them, change how the brain transforms sensory information into action. To address this question, we recorded neural activity in a prefrontal sensorimotor area while monkeys naturally switched between exploring and exploiting rewarding options...
December 27, 2017: Neuron
https://www.readbyqxmd.com/read/29289618/synchronous-and-asynchronous-perceptual-bindings-of-colour-and-motion-following-identical-stimulations
#13
Morgan E McIntyre, Derek H Arnold
When a moving surface alternates in colour and direction, perceptual couplings of colour and motion can differ from their physical correspondence. Periods of motion tend to be perceptually bound with physically delayed colours - a colour / motion perceptual asynchrony. This can be eliminated by motion transparency. Here we show that the colour / motion perceptual asynchrony is not invariably eliminated by motion transparency. Nor is it an inevitable consequence given a particular physical input. Instead, it can emerge when moving surfaces are perceived as alternating in direction, even if those surfaces seem transparent, and it is eliminated when surfaces are perceived as moving invariably...
December 28, 2017: Vision Research
https://www.readbyqxmd.com/read/29289617/the-anterior-ventrolateral-temporal-lobe-contributes-to-boosting-visual-working-memory-capacity-for-items-carrying-semantic-information
#14
Rocco Chiou, Matthew A Lambon Ralph
Working memory (WM) is a buffer that temporarily maintains information, be it visual or auditory, in an active state, caching its contents for online rehearsal or manipulation. How the brain enables long-term semantic knowledge to affect the WM buffer is a theoretically significant issue awaiting further investigation. In the present study, we capitalise on the knowledge about famous individuals as a 'test-case' to study how it impinges upon WM capacity for human faces and its neural substrate. Using continuous theta-burst transcranial stimulation combined with a psychophysical task probing WM storage for varying contents, we provide compelling evidence that (1) faces (regardless of familiarity) continued to accrue in the WM buffer with longer encoding time, whereas for meaningless stimuli (colour shades) there was little increment; (2) the rate of WM accrual was significantly more efficient for famous faces, compared to unknown faces; (3) the right anterior-ventrolateral temporal lobe (ATL) causally mediated this superior WM storage for famous faces...
December 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29283025/polycomb-repressive-complex-2-emerging-roles-in-the-central-nervous-system
#15
Pei-Pei Liu, Ya-Jie Xu, Zhao-Qian Teng, Chang-Mei Liu
The polycomb repressive complex 2 (PRC2) is responsible for catalyzing both di- and trimethylation of histone H3 at lysine 27 (H3K27me2/3). The subunits of PRC2 are widely expressed in the central nervous system (CNS). PRC2 as well as H3K27me2/3, play distinct roles in neuronal identity, proliferation and differentiation of neural stem/progenitor cells, neuronal morphology, and gliogenesis. Mutations or dysregulations of PRC2 subunits often cause neurological diseases. Therefore, PRC2 might represent a common target of different pathological processes that drive neurodegenerative diseases...
December 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29281841/developmental-emergence-of-adult-neural-stem-cells-as-revealed-by-single-cell-transcriptional-profiling
#16
Scott A Yuzwa, Michael J Borrett, Brendan T Innes, Anastassia Voronova, Troy Ketela, David R Kaplan, Gary D Bader, Freda D Miller
Adult neural stem cells (NSCs) derive from embryonic precursors, but little is known about how or when this occurs. We have addressed this issue using single-cell RNA sequencing at multiple developmental time points to analyze the embryonic murine cortex, one source of adult forebrain NSCs. We computationally identify all major cortical cell types, including the embryonic radial precursors (RPs) that generate adult NSCs. We define the initial emergence of RPs from neuroepithelial stem cells at E11.5. We show that, by E13...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29279861/the-magnitude-of-trial-by-trial-neural-variability-is-reproducible-over-time-and-across-tasks-in-humans
#17
Ayelet Arazi, Gil Gonen-Yaacovi, Ilan Dinstein
Numerous studies have shown that neural activity in sensory cortices is remarkably variable over time and across trials even when subjects are presented with an identical repeating stimulus or task. This trial-by-trial neural variability is relatively large in the prestimulus period and considerably smaller (quenched) following stimulus presentation. Previous studies have suggested that the magnitude of neural variability affects behavior such that perceptual performance is better on trials and in individuals where variability quenching is larger...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29275843/transdiagnostic-deviant-facial-recognition-for-implicit-negative-emotion-in-autism-and-schizophrenia
#18
Angela Ciaramidaro, Sven Bölte, Sabine Schlitt, Daniela Hainz, Fritz Poustka, Bernhard Weber, Christine Freitag, Henrik Walter
Impaired facial affect recognition (FAR) is observed in schizophrenia and autism spectrum disorder (ASD) and has been linked to amygdala and fusiform gyrus dysfunction. ASD patient's impairments seem to be more pronounced during implicit rather than explicit FAR, whereas for schizophrenia data are inconsistent. However, there are no studies comparing both patient groups in an identical design. The aim of this three-group study was to identify (i) whether FAR alterations are equally present in both groups, (ii) whether they are present rather during implicit or explicit FAR, (iii) and whether they are conveyed by similar or disorder-specific neural mechanisms...
December 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29238891/can-human-experts-predict-solubility-better-than-computers
#19
Samuel Boobier, Anne Osbourn, John B O Mitchell
In this study, we design and carry out a survey, asking human experts to predict the aqueous solubility of druglike organic compounds. We investigate whether these experts, drawn largely from the pharmaceutical industry and academia, can match or exceed the predictive power of algorithms. Alongside this, we implement 10 typical machine learning algorithms on the same dataset. The best algorithm, a variety of neural network known as a multi-layer perceptron, gave an RMSE of 0.985 log S units and an R2 of 0.706...
December 13, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29237855/sex-specific-adaptation-and-genomic-responses-to-y-chromosome-presence-in-female-reproductive-and-neural-tissues
#20
Alan T Branco, Rute M Brito, Bernardo Lemos
Y chromosomes typically harbour a small number of genes and an abundance of repetitive sequences. In Drosophila, the Y chromosome comprises multimegabase long segments of repetitive DNA and a handful of protein-coding genes. In mammals, the Y chromosome also harbours a disproportionally high abundance of repeats. Here, we built on a Drosophila melanogaster model in which the Y chromosome is decoupled from sexual determination. Genotypes were genetically identical for the autosomes, X chromosome, and mitochondria, but differ by the presence or dose of the Y chromosome...
December 20, 2017: Proceedings. Biological Sciences
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