Ruofan Chen, Hendrik Glauninger, Darren N Kahan, Julia Shangguan, Joseph R Sachleben, Joshua A Riback, D Allan Drummond, Tobin R Sosnick
Eukaryotic cells form condensates to sense and adapt to their environment [S. F. Banani, H. O. Lee, A. A. Hyman, M. K. Rosen, Nat. Rev. Mol. Cell Biol. 18 , 285-298 (2017), H. Yoo, C. Triandafillou, D. A. Drummond, J. Biol. Chem. 294 , 7151-7159 (2019)]. Poly(A)-binding protein (Pab1), a canonical stress granule marker, condenses upon heat shock or starvation, promoting adaptation [J. A. Riback et al. , Cell 168 , 1028-1040.e19 (2017)]. The molecular basis of condensation has remained elusive due to a dearth of techniques to probe structure directly in condensates...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America