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Arthritis and rheumatism

Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Körner, Huaxun Wu, Wei Wei
The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Treatment with losartan (15 mg/kg) alone and in combination with a low dose of methotrexate (MTX 0.25 mg/kg/3 days) significantly suppressed the progression of CIA. Secondary paw swelling, joint destruction and the presence of pro-inflammatory cytokines (TNF-α and IFN-γ) in the serum were alleviated after treatment...
November 13, 2018: Inflammopharmacology
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Sonia Farah
Objective: To investigate the construct validity, reliability (internal consistency and retest reliability), and feasibility of the patient-reported outcomes thermometer-5-item scale (5T-PROs), a new tool to measure overall health status in patients with painful chronic rheumatic diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axialSpA), and fibromyalgia (FM). Methods: Consecutive patients have been involved in this study...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Ni Yan, Ding-Sheng Wen, Yue-Rui Zhao, Shun-Jun Xu
BACKGROUND: Epimedium sagittatum ( Zucc.) Maxim., Ying-Yang-Huo in Chinese has been used as a traditional Chinese medicine and is deemed to "reinforce the kidney Yang". Previous studies showed that E. sagittatum could modulate the immune system and treat some chronic disease such as rheumatic arthritis, cardiovascular diseases and osteoporosis. The aim of this study is to evaluate the anti-inflammatory effects of ethyl acetate extracts (YYHs) of E. sagittatum and its mechanisms of action...
November 13, 2018: BMC Complementary and Alternative Medicine
Jacob R Stever, Grant W Cannon, Chia-Chen Teng, Neil A Accortt, David H Collier, Brian C Sauer
OBJECTIVES: To examine factors associated with major therapeutic changes (MTC) among US Veterans with moderate/severe rheumatoid arthritis (RA) based on Disease Activity Score based on 28 joints (DAS28). METHODS: We used data from patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry from 1/1/2006 through 12/31/2014. The index date was a clinic visit with DAS28 >3.2 (moderate/severe disease) following an 18-month pre-index period that included ≥2 DAS28 measurements ≥60 days apart...
November 12, 2018: Clinical and Experimental Rheumatology
Richard Seto, Lauren M Mathias, Andrew Kelly, Richard S Panush
We cared for a woman with sero-positive rheumatoid arthritis (RA), in clinical remission on oral methotrexate (MTX) and hydroxychloroquine, who wished to donate a kidney to a brother with end-stage renal disease (ESRD). We could find scant literature about this unusual clinical circumstance, and therefore review pertinent aspects of renal disease in RA, perioperative medical management, maintenance of disease remission, outcomes for RA patients who have donated kidneys, and relevant ethical issues. Renal complications in RA are not uncommon, with as many as 50% of patients at risk of reduced eGFR...
November 8, 2018: Clinical Rheumatology
Lazaros I Sakkas, Dimitrios Daoussis, Athanasios Mavropoulos, Stamatis-Nick Liossis, Dimitrios P Bogdanos
OBJECTIVE: Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing autoimmune diseases. The aim of the study was to review the literature related to Bregs in autoimmune rheumatic diseases (ARDs). METHODS: A literature review of publications in PUBMED published in English was performed using the relevant combinations of terms...
October 15, 2018: Seminars in Arthritis and Rheumatism
Meghan J Mooradian, Mazen Nasrallah, Justin F Gainor, Kerry L Reynolds, Justine V Cohen, Donald P Lawrence, Eli M Miloslavsky, Minna J Kohler, Ryan J Sullivan, Sara R Schoenfeld
BACKGROUND: The use of immune checkpoint inhibition (ICI) has revolutionized cancer treatment. However, these medications are associated with significant and potentially debilitating immune-related adverse events (irAEs). While certain toxicities have been well studied, rheumatic complications have been less widely recognized and characterized. METHODS: We report our experience of patients who were evaluated by rheumatology after the development of a suspected rheumatic irAE following ICI treatment...
October 16, 2018: Seminars in Arthritis and Rheumatism
Isabelle Amigues, Aylin Tugcu, Cesare Russo, Jon T Giles, Rachelle Morgenstein, Afshin Zartoshti, Christian Schulze, Raul Flores, Sabahat Bokhari, Joan M Bathon
OBJECTIVES: To determine the prevalence and correlates of subclinical myocardial inflammation in rheumatoid arthritis (RA). METHODS: RA patients (n=119) without known cardiovascular disease (CVD) underwent cardiac 18-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT). Myocardial FDG uptake was assessed visually and quantitatively by standardized uptake values (SUV). Multivariable linear regression was used to assess the associations of patient characteristics with myocardial SUV...
November 8, 2018: Arthritis & Rheumatology
S A Kerrigan, I B McInnes
PURPOSE OF REVIEW: Given the recent increase in the profile and use of Janus kinase inhibitors (JAKinibs) in adult patients with rheumatic diseases, we aimed to review the current evidence accruing for use in paediatric rheumatology patients. RECENT FINDINGS: Significant advances have been made in the management of rheumatic diseases in the past two decades. The introduction of biologic agents in both adults and children has provided significant improvements to patient outcomes and led to better quality of life...
November 8, 2018: Current Rheumatology Reports
Tamer A Gheita, Nahla N Eesa
Medical knowledge in ancient Egypt had a remarkable reputation since rulers of other empires used to request the pharaoh to send them their best physician to treat their beloved ones. Many rheumatologic conditions as giant-cell arteritis, reactive arthritis and other forms of spondyloarthritis have been identified in ancient Egyptian materials. Rheumatologists in Egypt are enormously expanding and mastering the tools that aid them in enhancing the management of rheumatic diseases. More Egyptian rheumatologists are actively participating in the annual European League Against Rheumatism (EULAR) and American College of Rheumatology conferences and those attached to well known state of the art centers are increasing...
November 7, 2018: Rheumatology International
Ana Martínez-Feito, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Borja Hernández-Breijo, María Ángeles González, Irene Monjo, Laura Nuño, Pilar Nozal, Dora Pascual-Salcedo, Alejandro Balsa
To investigate the effect of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) with adalimumab or infliximab on maintaining serum drug and clinical outcomes after the first year of treatment in patients with rheumatoid arthritis (RA). Second, to assess the influence of methotrexate (MTX) dose on these outcomes. Ninety-two patients with RA starting infliximab (n = 67) or adalimumab (n = 25) tumor necrosis factor inhibitor (TNFi) with available drug levels and clinical improvement assessment (European League Against Rheumatism [EULAR] response) after 12 months were included...
November 6, 2018: Clinical Rheumatology
April Jorge, Cindy Ung, Lucy H Young, Ronald B Melles, Hyon K Choi
Despite advances in therapy for rheumatic diseases, hydroxychloroquine remains almost universally recommended for the treatment of systemic lupus erythematosus (SLE), and is often used in the management of other rheumatic diseases such as rheumatoid arthritis (RA). However, the major dose-limiting toxicity of hydroxychloroquine is retinopathy that can lead to loss of vision. New highly sensitive screening methods can identify early stages of retinopathy, and studies that include these modalities have indicated a substantially higher prevalence of hydroxychloroquine retinopathy than was previously recognized, resulting in revisions to ophthalmology guidelines and the recommendation of a low dose of hydroxychloroquine for many patients...
November 6, 2018: Nature Reviews. Rheumatology
Linda Lei, Stephen Morgan, Eleana Ntatsaki, Coziana Ciurtin
Systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS) can be associated with inflammatory arthritis, which is underdiagnosed by clinical examination. The aim of this cross-sectional, observational study was to compare, for the first time, the ultrasound (US)-detected joint abnormalities in these two diseases and to define the role of US in patient management. Participants had SLE (n = 18) and SS (n = 23), symptoms of hand joint pain and no previous diagnosis of arthritis. Data on disease activity, duration, damage scores, inflammatory and serologic markers, treatment and clinical and ultrasound parameters (derived from the assessment of 902 joints) were analysed and correlated using descriptive statistics, correlation tests and regression models...
November 3, 2018: Ultrasound in Medicine & Biology
Levent Kilic, Abdulsamet Erden, Yusuf Ziya Sener, Berkan Armagan, Alper Sari, Umut Kalyoncu, Omer Karadag, Ali Akdogan, Ismail Dogan, Sule Apras Bilgen, Sedat Kiraz, Ihsan Ertenli
Secondary amyloid A (AA) amyloidosis is a late and serious complication of poorly controlled, chronic inflammatory diseases. Rheumatoid arthritis (RA) patients with poorly controlled, longstanding disease and those with extra-articular manifestations are under risk for the development of AA amyloidosis. Although new drugs have proven to be significantly effective in the treatment of secondary AA amyloidosis, no treatment modality has proven to be ideal. To date, only in small case series preliminary clinical improvement have been shown with rituximab therapy for AA amyloidosis secondary to RA that is refractory to TNF-α inhibitors (TNF-i) therapy...
November 5, 2018: Biomolecules
Sarah Hewlett, Andrew Haig-Ferguson, Emily Rose-Parfitt, Serena Halls, Samuel Freke, Paul Creamer
OBJECTIVE: Successful biologic disease-modifying anti-rheumatic drug (bDMARD) dose reduction appears increasingly possible from clinical trials. The present study aimed to understand the patient perspective of bDMARD dose reduction. METHODS: Patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis who were self-administering subcutaneous bDMARDs therapy at two National Health Service trusts participated in semi-structured interviews. To capture multiple experiences, patients were purposefully sampled for a range of age, gender, disease duration, reducing/not reducing bDMARDs and either within 3-12 months of bDMARD initiation or ≥12 months and in remission/low disease activity...
November 6, 2018: Musculoskeletal Care
Md Nahiduzzamane Shazzad, Shamim Ahmed, Syed Atiqul Haq, Md Nazrul Islam, Md Abu Shahin, Minhaj Rahim Choudhury, Abu Tahir Muhammad Tanveer Hasan, Syed Jamil Abdal, Johannes Jacobus Rasker
OBJECTIVE: To study the prevalence of musculoskeletal (MSK) symptoms and disorders among garment workers in Bangladesh, to look for possible relationships between pain location and type of work performed and to estimate the prevalence of rheumatological diagnoses. METHODS: A cross-sectional pilot study among 350 garment workers using the COPCORD (Community Oriented Program for Control of Rheumatic Disorders) methodology. Subjects with musculoskeletal pain were examined by rheumatologists for rheumatological diagnosis...
November 5, 2018: International Journal of Rheumatic Diseases
Shunsaku Nakagawa, Mayumi Nakaishi, Motomu Hashimoto, Hiromu Ito, Wataru Yamamoto, Ran Nakashima, Masao Tanaka, Takao Fujii, Tomohiro Omura, Satoshi Imai, Takayuki Nakagawa, Atsushi Yonezawa, Hirohisa Imai, Tsuneyo Mimori, Kazuo Matsubara
For the optimum efficacy of disease-modifying anti-rheumatic drugs (DMARDs), patients need to be adherent to their medication regimen. To clarify the effects of medication adherence on disease activity in Japanese patients with rheumatoid arthritis (RA), we conducted a cohort study in patients with various stages of RA. Patients were enrolled from the Kyoto University RA Management Alliance cohort, and followed up prospectively for 12 months. In this study, a total of 475 patients were analyzed and divided into 9 groups according to their medication adherence and the RA disease duration...
2018: PloS One
Ying Long, Weilin Chen, Qian Du, Xiaoxia Zuo, Honglin Zhu
Scleroderma (systemic sclerosis, SSc) is a highly heterogeneous rheumatic disease, and uncontrolled fibrosis in visceral organs is the major cause of death in patients. The transforming growth factor-β (TGF-β) and WNT/β-catenin signaling pathways, along with signal transducer and activator of transcription 3 (STAT3), play crucial roles in this fibrotic process. Currently, no therapy is available that effectively arrests or reverses the progression of fibrosis in patients with SSc. Ubiquitination is an important post-translational modification that controls many critical cellular functions...
2018: Frontiers in Immunology
Heikki Relas, Silja Kosola
OBJECTIVES: Across diagnosis groups, transition of adolescents and young adults from children's hospitals to adult care associates with decreased treatment adherence and suboptimal treatment results. Our aim was to compare the health-related quality of life (HRQoL) and disease activity of juvenile idiopathic arthritis (JIA) patients after the transfer of care to the adult clinic and adult patients in the same outpatient clinic. METHODS: All consecutive JIA patients aged 16 to 20 years who visited the transition clinic between September 2016 and August 2017 and all consecutive adult onset arthritis patients between December 2016 and August 2017 in the rheumatology outpatient clinic of Helsinki University Hospital were evaluated...
October 29, 2018: Clinical Rheumatology
Bartłomiej Kisiel, Robert Kruszewski, Aleksandra Juszkiewicz, Anna Raczkiewicz, Artur Bachta, Krzysztof Kłos, Krzysztof Duda, Artur Maliborski, Konrad Szymański, Rafał Płoski, Marek Saracyn, Stanisław Niemczyk, Katarzyna Kisiel, Małgorzata Tłustochowicz, Witold Tłustochowicz
Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized by increased cardiovascular morbidity. Several previous studies assessed associations between common atherosclerotic genetic risk factors and subclinical atherosclerosis (SA) in RA patients, yet most of them gave negative results. We undertook a cross-sectional study to evaluate the association between previously reported SNPs and subclinical atherosclerosis in a cohort of Polish RA patients. 29 SNPs associated with atherosclerosis in general population were genotyped in 289 RA patients: 116 patients with SA (increased carotid intima-media thickness and/or presence of carotid plaque) and 173 patients without SA...
October 29, 2018: Rheumatology International
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