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Arthritis and rheumatism

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Yipeng Wang, Jinlong Li, Lixin Guo, Guangsen Wu
Modern pharmacological studies revealed that Celastrol exhibits anti‑inflammation, anti‑bacteria, anti‑virus, anti‑fertility, insect‑resistance functions and has been used for the treatment of rheumatism, rheumatoid arthritis, blood diseases, skin diseases and agricultural insecticide. The present study aimed to investigate the effects of Celastrol on glucocorticoid‑induced osteoporosis (GIOP) and the underlying molecular mechanisms. The findings of the current study revealed that Celastrol reduced body weight, urine calcium/creatinine, tartrate‑resistant acid phosphatase 5b, C‑terminal telopeptide of type I collagen, and induced osteocalcin in GIOP rats...
September 3, 2018: Molecular Medicine Reports
Thomas Davergne, Adrien Pallot, Agnès Dechartres, Bruno Fautrel, Laure Gossec
OBJECTIVE: Wearable activity trackers (WATs) could be a promising strategy to improve physical activity (PA) in patients with rheumatic and musculoskeletal diseases (RMDs). The aim was to assess the adherence and effectiveness of WATs to increase PA levels in RMDs. METHODS: A systematic review was performed to identify all cohorts and controlled trials evaluating WATs in RMDs, published between 2000 and 2018, by searching MEDLINE, EMBASE, PsycINFO and Cochrane. Data collected pertained to (a) adherence, (b) effectiveness on PA or (c) effectiveness on symptoms (pain, function, quality of life or fatigue)...
September 17, 2018: Arthritis Care & Research
J Nowotny, B El-Zayat, J Goronzy, A Biewener, F Bausenhart, S Greiner, P Kasten
BACKGROUND: In the treatment of lateral epicondylitis (LE), the role of a new dynamic wrist orthosis is unclear. PATIENTS AND METHODS: Patients suffering from a LE longer than 3 months were multicentrically and prospectively randomized into a physiotherapeutic group (PT group) and in a physiotherapy group plus wrist orthosis (PT + O group). Physiotherapy consisted of daily eccentric strengthening exercises under initial professional supervision. Inclusion criteria were a Placzek score greater than 4...
September 15, 2018: European Journal of Medical Research
Ahmet Şükrü Aynacıoğlu, Ayhan Bilir, Mehmet Yakup Tuna
Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable levels in healthy adults. However, MK is upregulated during tissue repair and in many pathologic conditions, mostly malignancies and inflammatory diseases. MK promotes a number of functions in target cells such as migration, proliferation, survival, growth, reproduction and repair, angiogenesis and gene expression. It acts as a pro-inflammatory cytokine and contributes to chronic inflammation via promoting chemotaxis and tissue infiltration of neutrophils and macrophages...
September 14, 2018: Modern Rheumatology
Fabrizio Cantini, Maurizio Benucci
Background: The recent approval of reference etanercept (re-ETN) biosimilars SB4, GP2015, and HD203 produced relevant changes in the management of rheumatoid arthritis (RA), psoriatic arthritis, and ankylosing spondylitis due to the considerably lower cost of these products and the consequent savings. Aims: To review the pharmacodynamics, pharmacokinetics, efficacy, and safety of ETN biosimilars when employed as first-line therapy or after transition from re-ETN...
2018: Biologics: Targets & Therapy
Wei Cao, Menglin Niu, Yulong Tong, Yuxuan Du, Weiwei Lou, Yiyang Mao, Yunpeng Dou, Huihui Yuan, Wenming Zhao
Wnt5a signalling plays pathological roles in synovial inflammation and bone destruction. In the present study, we designed four human Wnt5a-based DNA recombinants and detected their effects on immunogenicity and anti-rheumatism in a collagen-induced arthritis (CIA) model. Histomorphometry and micro-CT scanning showed that the phWnt5a-NL was superior to other recombinants because it resulted in decreased severity of arthritis, histopathological scores of synovial inflammation and bone erosion in CIA mice. In addition, ELISA and TRAP staining showed that the phWnt5a-NL-immunized CIA mice had reductions in the serum concentrations of the rheumatoid-associated cytokines IL-1β and RANKL and in osteoclastogenesis...
September 11, 2018: Biochemical and Biophysical Research Communications
Frederick Wolfe, Brian Walitt, Serge Perrot, Johannes J Rasker, Winfried Häuser
PURPOSE: Multiple clinical and epidemiological studies have provided estimates of fibromyalgia prevalence and sex ratio, but different criteria sets and methodology, as well as bias, have led to widely varying (0.4%->11%) estimates of prevalence and female predominance (>90% to <61%). In general, studies have failed to distinguish Criteria based fibromyalgia (CritFM) from Clinical fibromyalgia (ClinFM). In the current study we compare CritFM with ClinFM to investigate gender and other biases in the diagnosis of fibromyalgia...
2018: PloS One
Charlene Tennyson, Aaron Kler, Anshuman Chaturvedi, Andreas Paschalis, Rajamiyer Venkateswaran
Symptomatic cardiac rheumatoid nodules are a rare but recognized manifestation of rheumatoid arthritis. We describe the surgical management of a rheumatic nodule involving the anterior leaflet of the mitral valve.
September 10, 2018: Journal of Cardiac Surgery
Rick Bucala, Marian Hannan
The founding of Arthritis & Rheumatism by the American Rheumatism Association in 1958 occurred at the advent of knowledge of immunologic abnormalities in patients with rheumatoid arthritis, SLE, and related disorders. Over its ensuing 60 year history, "A&R" (renamed to Arthritis & Rheumatology in 2014) developed into a preeminent publication for disseminating research findings and advancing the field scientifically. Landmark papers included the role of autoantibodies and lymphocytes in rheumatic diseases and, in recent years, the clinical translation of cell and cytokine-based paradigms of disease...
September 10, 2018: Arthritis Care & Research
Minning Shen, Junyu Zhang, Kai Qian, Chunmei Li, Wenyu Xu, Bingjie Gu, Xiaoqin Wang, Qijie Ren, Leilei Yang, Hai Yuan, Dinglei Su, Xingguo Chen
To retrospectively analyze the efficacy and safety of febuxostat on gout patients with low serum uric acid level. A study was conducted in Nanjing First Hospital from October 2015 to September 2016. Thirty nine acute gouty arthritis patients from the emergency and outpatient department were included. Patients met the 2015 Gout Classification Criteria revised by American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and had urate deposition around the joints detected by dual-energy computerized tomography (DECT)...
September 9, 2018: Clinical Rheumatology
Nadia M T Roodenrijs, Maria J H de Hair, Marlies C van der Goes, Johannes W G Jacobs, Paco M J Welsing, Désirée van der Heijde, Daniel Aletaha, Maxime Dougados, Kimme L Hyrich, Iain B McInnes, Ulf Mueller-Ladner, Ladislav Senolt, Zoltan Szekanecz, Jacob M van Laar, György Nagy
OBJECTIVES: Patients with difficult-to-treat rheumatoid arthritis (RA) remain symptomatic despite treatment according to current European League Against Rheumatism (EULAR) management recommendations. These focus on early phases of the disease and pharmacological management. We aimed to identify characteristics of difficult-to-treat RA and issues to be addressed in its workup and management that are not covered by current management recommendations. METHODS: An international survey was conducted among rheumatologists with multiple-choice questions on disease characteristics of difficult-to-treat RA...
September 7, 2018: Annals of the Rheumatic Diseases
Davood Hekmatpou, Sepideh Mortaji, Masoud Rezaei, Millad Shaikhi
PURPOSE: This study aimed to determine the effectiveness of olive oil in controlling morning inflammatory pain of phalanges and knees among women with rheumatoid arthritis. DESIGN: This is a randomized clinical trial, which was done in Arak, Iran. METHOD: After selecting 60 women based on a convenience sampling method, they were randomly allocated into five groups. A demographic questionnaire, the Visual Analogue Scale, and the Disease Activity Score 28 were completed...
September 6, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Till Uhlig, Sella A Provan
Clinically relevant fatigue is common in patients with rheumatoid arthritis (RA) and might be expected to be related to patient age and disease severity. This review provides a brief introduction to fatigue as a patient-reported outcome that contributes significantly to burden of disease, with a focus on the evidence in elderly patients, and gives an overview of our current understanding of the factors that contribute to fatigue. We summarize the evidence for the effects of pharmacological (disease-modifying anti-rheumatic drugs, DMARDs) and non-pharmacological interventions for fatigue...
September 6, 2018: Drugs & Aging
J A Walsh, A B Gottlieb, B Hoepken, T Nurminen, P J Mease
To report long-term efficacy of certolizumab pegol (CZP) treatment with and without concomitant DMARDs in patients with psoriatic arthritis (PsA). RAPID-PsA (NCT01087788) was double-blind and placebo-controlled to week 24, dose-blind to week 48, and open-label to week 216. Patients had active PsA with ≥ 1 failed DMARD. At baseline, patients were randomized 1:1:1 to CZP 200 mg every 2 weeks: CZP 400 mg every 4 weeks: placebo. CZP-randomized patients continued their dose into open-label. Observed case efficacy data are reported to week 216 for week 0 CZP-randomized patients (dose combined) with and without baseline DMARD use (DMARD+/DMARD-)...
September 6, 2018: Clinical Rheumatology
S-C Bae, Y H Lee
OBJECTIVES: The relative efficacy and safety of tofacitinib and baricitinib were assessed in patients with rheumatoid arthritis (RA) with an inadequate response to disease-modifying anti-rheumatic drugs (DMARDs) or biologics. METHODS: We performed a Bayesian network meta-analysis to combine direct and indirect evidence from randomized controlled trials (RCTs) to examine the efficacy and safety of tofacitinib and baricitinib in combination with DMARDs in RA patients with an inadequate DMARD or biologic response...
September 6, 2018: Zeitschrift Für Rheumatologie
J Holinka
There is a trend towards a reduction in joint-preserving hip surgery, such as synovectomy and total hip joint replacement in rheumatic patients. This is mostly due to the success of biological disease-modifying antirheumatic drugs (bDMARD) in systemic anti-rheumatic therapy. The results of hip surgery in rheumatic patients are comparable to those in non-rheumatic patients, except for prosthetic joint infections, which are higher in patients with rheumatoid arthritis. Especially in hip surgery there was a big evolution in the last few years including a broad range of minimally invasive surgical methods, such as hip arthroscopy, mini-open hip surgery and minimally invasive hip arthroplasty with bone preservation or short femoral shafts...
September 6, 2018: Zeitschrift Für Rheumatologie
Samantha L Hider, Milica Bucknall, Kelly Cooke, Kendra Cooke, Andrew G Finney, Dave Goddin, Emma L Healey, Susie Hennings, Daniel Herron, Clare Jinks, Martyn Lewis, Annabelle Machin, Christian Mallen, Simon Wathall, Carolyn A Chew-Graham
Background: Patients with inflammatory rheumatic conditions such as rheumatoid arthritis, polymyalgia rheumatica and ankylosing spondylitis are at increased risk of common comorbidities such as cardiovascular disease, osteoporosis and anxiety and depression which lead to increased morbidity and mortality. These associated morbidities are often un-recognized and under-treated. While patients with other long-term conditions such as diabetes are invited for routine reviews in primary care, which may include identification and management of co-morbidities, at present this does not occur for patients with inflammatory conditions, and thus, opportunities to diagnose and optimally manage these comorbidities are missed...
2018: Journal of Comorbidity
Waleed Azam, Uzma Erum, Asif Jan Muhammad
Essential thrombocytosis (ET) has rarely been reported with autoimmune rheumatic disorders. We report a case of young female, diagnosed case of Rheumatoid arthritis (RA), who had been overlooked for her raised platelet counts. Later her symptoms of impending digital gangrene led to an active search for her thrombocytosis. JAK2 mutation came out to be positive and she was diagnosed as ET associated with RA. She was treated with Hydroxyurea and Aspirin, in addition to her RA treatment. Patient responded well to the treatment and her platelet counts have been gradually improved, however, she developed gangrene of toe, for which amputation of distal phalanx of toe and nail excision was done, later in the disease course...
July 2018: Pakistan Journal of Medical Sciences Quarterly
Zhi-Peng Wu, Pei Zhang, Jian-Zhong Bai, Yuan Liang, Jin-Shan He, Jing-Cheng Wang
The purpose of the present meta-analysis was to assess the efficacy and safety of baricitinib for active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biological disease-modifying anti-rheumatic drugs (DMARDs). A total of 7 randomized controlled trials (RCTs) were included. The primary effective outcome was the RA improvement to reach an American College of Rheumatology 20% (ACR20) response rate. The safety outcomes were composed of clinical laboratory parameters...
September 2018: Experimental and Therapeutic Medicine
Deepan S Dalal, Josefina Duran, Tina Brar, Rasha Alqadi, Christopher Halladay, Alisha Lakhani, James L Rudolph
OBJECTIVE: Biologic anti-rheumatic drugs are used with less frequency among older patients compared to young patients. This population is less represented in studies performed to evaluate the efficacy and safety of this drugs. We aimed to assess the efficacy and safety of biological agents between the older RA patients compared to young. METHODS: A comprehensive, systematic search was conducted in major indexing databases using key terms for RA and each biological agent...
July 31, 2018: Seminars in Arthritis and Rheumatism
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