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Rheumatology review

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https://www.readbyqxmd.com/read/29149821/statins-therapy-for-connective-tissue-diseases-new-therapeutic-opportunities
#1
Przemyslaw J Kotyla, Eugene J Kucharz
Background and Objective Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductase inhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently, the properties of statins, separate from their lipid lowering activity have attracted much attention. These properties that cover a wide area of physiopathological activities including cell maturation, immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity. Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity, reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelial activity and damage...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29142041/occurrence-of-serious-infection-in-patients-with-rheumatoid-arthritis-treated-with-biologics-and-denosumab-observed-in-a-clinical-setting
#2
Arthur N Lau, Matthew Wong-Pack, Rod Rodjanapiches, George Ioannidis, Sally Wade, Leslie Spangler, Akhila Balasubramanian, Nicola Pannacciulli, Celia J F Lin, Patrick Roy-Gayos, William G Bensen, Robert Bensen, Jonathan D Adachi
OBJECTIVE: Previous studies combining biologic disease-modifying antirheumatic drugs (bDMARD) to treat rheumatoid arthritis (RA) have shown an increased risk of infection. However, the risk of infection with concurrent use of denosumab, a biologic agent for the treatment of osteoporosis, and a bDMARD remains unclear. Here, we evaluated the incidence of serious and opportunistic infections in patients treated concurrently with denosumab and a bDMARD and patients treated with a bDMARD alone...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29140820/renal-effects-of-cytokines-in-hypertension
#3
Yi Wen, Steven D Crowley
PURPOSE OF REVIEW: Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS: Populations of cells from both the innate and adaptive immune systems contribute to hypertension by modulating functions of the vasculature and epithelial cells in the kidney...
November 14, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29140474/identification-of-novel-systemic-sclerosis-biomarkers-employing-aptamer-proteomic-analysis
#4
Peter J Wermuth, Sonsoles Piera-Velazquez, Sergio A Jimenez
There is an important unmet need for clinically validated non-invasive biomarkers for SSc diagnosis, assessment of disease activity, extent of internal organ involvement, therapeutic response and prognosis. There is also an unmet need for biomarkers to accurately differentiate primary RP from recent onset RP evolving into SSc. The lack of sensitive and specific biomarkers for SSc and SSc-associated RP is a limitation for the optimal clinical management of these patients. The development of highly sensitive and specific proteomic analysis employing aptamers and the expansion in the number of proteins that can be specifically identified by aptamer proteomics have opened new horizons for biomarker discovery...
November 13, 2017: Rheumatology
https://www.readbyqxmd.com/read/29127246/non-oncologic-applications-of-pet-ct-and-pet-mr-in-musculoskeletal-orthopedic-and-rheumatologic-imaging-general-considerations-techniques-and-radiopharmaceuticals
#5
Ali Gholamrezanezhad, Kyle Basques, Ali Batouli, Mojtaba Olyaie, George Matcuk, Abass Alavi, Hossein Jadvar
Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29120258/evaluation-of-the-alternative-classification-criteria-of-systemic-lupus-erythematosus-established-by-systemic-lupus-international-collaborating-clinics-slicc
#6
Kenji Oku, Tatsuya Atsumi, Yuji Akiyama, Hirofumi Amano, Naoto Azuma, Toshiyuki Bohgaki, Yu Funakubo Asanuma, Tetsuya Horita, Tadashi Hosoya, Kunihiro Ichinose, Masaru Kato, Yasuhiro Katsumata, Yasushi Kawaguchi, Atsushi Kawakami, Tomohiro Koga, Hitoshi Kohsaka, Yuya Kondo, Kanae Kubo, Masataka Kuwana, Akio Mimori, Tsuneyo Mimori, Toshihide Mimura, Kosaku Murakami, Kazuhisa Nakano, Shingo Nakayamada, Hiroshi Ogishima, Kazumasa Ohmura, Kazuyoshi Saito, Hajime Sano, Mihoko Shibuya, Yuko Takahashi, Yoshinari Takasaki, Tsutomu Takeuchi, Naoto Tamura, Yoshiya Tanaka, Hiroto Tsuboi, Shinichiro Tsunoda, Naoichiro Yukawa, Noriyuki Yamakawa, Kazuhiko Yamamoto, Takayuki Sumida
OBJECTIVE: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. METHODS: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus...
November 9, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29110377/abnormal-esophageal-acid-exposure-on-high-dose-proton-pump-inhibitor-therapy-is-common-in-systemic-sclerosis-patients
#7
E K Stern, D A Carlson, S Falmagne, A D Hoffmann, M Carns, J E Pandolfino, M Hinchcliff, D M Brenner
BACKGROUND: Esophageal dysfunction and gastro-esophageal reflux disease (GERD) are common among patients with systemic sclerosis (SSc). Although high-dose proton pump inhibitors (PPIs) typically normalize esophageal acid exposure, the effectiveness of PPI therapy has not been systematically studied in SSc patients. The aim of this study was to characterize reflux in SSc patients on high-dose PPI using esophageal pH-impedance testing. METHODS: In this case-controlled retrospective analysis, 38 patients fulfilling 2013 American College of Rheumatology SSc criteria who underwent esophageal pH-impedance testing on twice-daily PPI between January 2014 and March 2017 at a tertiary referral center were compared with a control-cohort of 38 non-SSc patients matched for PPI formulation and dose, hiatal hernia size, age, and gender...
November 6, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29108831/are-the-acr-2010-diagnostic-criteria-for-fibromyalgia-better-than-the-1990-criteria
#8
REVIEW
Piercarlo Sarzi-Puttini, Fabiola Atzeni, Ignazio Francesco Masala, Fausto Salaffi, Joab Chapman, Ernest Choy
Fibromyalgia (FM) is difficult to diagnose and manage chronic pain condition whose symptoms have no clear pathophysiological cause, although it is thought that patient hypersensitivity to a range of stimuli may give rise to mechanical hyperalgesia as a result of altered central nociceptive processing. The 1990 American College of Rheumatology (ACR) classification criteria, which have been widely used in clinical practice, require the existence of chronic widespread pain (CWP) for >3months, and the presence of at least 11 out of 18 specified tender points upon digital palpation, although this latter criterion has long been criticised...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29103429/immunotherapeutics-in-pediatric-autoimmune-central-nervous-system-disease-agents-and-mechanisms
#9
Margherita Nosadini, Stefano Sartori, Suvasini Sharma, Russell C Dale
Beyond the major advances produced by careful clinical-radiological phenotyping and biomarker development in autoimmune central nervous system disorders, a comprehensive knowledge of the range of available immune therapies and a deeper understanding of their action should benefit therapeutic decision-making. This review discusses the agents used in neuroimmunology and their mechanisms of action. First-line treatments typically include corticosteroids, intravenous immunoglobulin, and plasmapheresis, while for severe disease second-line "induction" agents such as rituximab or cyclophosphamide are used...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29102487/reexamining-mechanic-s-hands-as-a-characteristic-skin-finding-in-dermatomyositis
#10
REVIEW
Josef Symon S Concha, Joseph F Merola, David Fiorentino, Victoria P Werth
Mechanic's hands is a poorly defined clinical finding that has been reported in a variety of rheumatologic diseases. Morphologic descriptions include hyperkeratosis on the sides of the digits that sometimes extends to the distal tips, diffuse palmar scale, and, more recently observed, linear discrete scaly papules in a similar lateral distribution. The association of mechanic's hands with dermatomyositis, although recognized, is still debatable. In this review, most studies have shown that mechanic's hands is commonly associated with dermatomyositis and displays histopathologic findings of interface dermatitis, colloid bodies and interstitial mucin which are consistent with a cutaneous connective tissue disease...
November 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29082050/a-case-of-rituximab-induced-necrotizing-fasciitis-and-a-review-of-the-literature
#11
Abdullateef Abdulkareem, Ryan S D'Souza, Oluwaseun Shogbesan, Anthony Donato
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29080437/nursing-sensitive-outcomes-in-patients-with-rheumatoid-arthritis-a-systematic-literature-review
#12
Patricia Minnock, Gabrielle McKee, Alexia Kelly, Sheree C Carter, Victoria Menzies, Denis O'Sullivan, Pam Richards, Mwidimi Ndosi, Yvonne van Eijk Hustings
BACKGROUND: Although rheumatology nursing has been shown to be effective in managing patients with rheumatoid arthritis, patient outcomes sensitive to nursing interventions (nursing sensitive outcomes) have not been systematically studied. OBJECTIVES: The objective of this study was to identify and delineate relevant patient outcomes measured in studies that reported nursing interventions in patients with rheumatoid arthritis. DESIGN: A systematic search was conducted from 1990 to 2016...
September 12, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29079235/outcomes-of-locking-plate-fixation-for-hindfoot-fusion-procedures-in%C3%A2-15-patients
#13
Kenneth Smith, Ibukunoluwa Araoye, Caleb Jones, Ashish Shah
Tibiotalocalcaneal arthrodesis is a salvage procedure for various end-stage foot and ankle pathologic entities. Several factors are known to influence the union rate after these procedures, including construct rigidity. The data on locked plates as a fixation technique have been inconclusive, with variable union rates reported. One recent study suggested that locking plates can lead to high nonunion rates owing to excessive rigidity. The purpose of the present study was to retrospectively examine the outcomes of locking plate fixation...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29074628/payments-by-us-pharmaceutical-and-medical-device-manufacturers-to-us-medical-journal-editors-retrospective-observational-study
#14
Jessica J Liu, Chaim M Bell, John J Matelski, Allan S Detsky, Peter Cram
Objective To estimate financial payments from industry to US journal editors.Design Retrospective observational study.Setting 52 influential (high impact factor for their specialty) US medical journals from 26 specialties and US Open Payments database, 2014.Participants 713 editors at the associate level and above identified from each journal's online masthead.Main outcome measures All general payments (eg, personal income) and research related payments from pharmaceutical and medical device manufacturers to eligible physicians in 2014...
October 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29071588/a-retrospective-medical-record-review-of-utilization-patterns-and-medical-resource-use-associated-with-repository-corticotropin-injection-among-patients-with-rheumatologic-diseases-in-the-united-states
#15
Winnie W Nelson, Michael J Philbin, Jack R Gallagher, Kylee Heap, Susan Carroll, George J Wan
INTRODUCTION: Repository corticotropin injection (RCI) has anti-inflammatory and immune-modulatory effects and is approved for multiple indications, including several rheumatologic conditions. The aims of this nationally representative, retrospective, observational study were to describe patient characteristics, RCI treatment patterns, and barriers to RCI use in patients with rheumatologic disease, and to compare medical resource use (MRU) before and after RCI therapy. METHODS: A random sample of US physicians was recruited to abstract the medical records of deidentified patients with a diagnosis of rheumatoid arthritis (RA), psoriatic arthritis (PsA), dermatomyositis/polymyositis (DM/PM), or systemic lupus erythematosus (SLE) who had been treated with RCI in the previous 24 months...
October 25, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29069018/thyroid-disorders-in-patients-with-newly-diagnosed-rheumatoid-arthritis-is-associated-with-poor-initial-treatment-response-evaluated-by-disease-activity-score-in-28-joints-c-reactive-protein-das28-crp-an-observational-cohort-study
#16
Amir Emamifar, Jørgen Hangaard, Inger Marie Jensen Hansen
To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29068601/rheumatoid-factor-and-anti-cyclic-citrullinated-peptide-anti-ccp-antibodies-with-hepatitis-b-and-hepatitis-c-infection-review
#17
Orhan Zengin, Hamit Yıldız, Zeynep Hanım Demir, Muhammed Sait Dağ, Musa Aydınlı, Ahmet Mesut Onat, Bünyamin Kısacık
BACKGROUND: Viruses are common and are involved in the etiology of idiopathic rheumatological diseases. Hepatitis B virus (HBV), a member of the family Hepadnaviridae and hepatitis C virus (HCV), play an important role in the undetermined etiology of arthritis. The clinical manifestations of hepatitis B and C show similarities with various diseases, such as rheumatic diseases. Anti-cyclic citrullinated peptide (anti-CCP) is a specific serological marker for rheumatoid arthritis. OBJECTIVES: The aim of this study was to analyze anti-CCP and rheumatoid factor (RF) levels in patients with a hepatitis B and C infection...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29065901/predictive-biological-markers-of-systemic-lupus-erythematosus-flares-a-systematic-literature-review
#18
Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau, Christophe Richez
BACKGROUND: The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). METHODS: A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29063464/diverse-patterns-of-anti-tnf-%C3%AE-induced-lupus-case-series-and-review-of-the-literature
#19
REVIEW
Ora Shovman, Shalev Tamar, Howard Amital, Abdulla Watad, Yehuda Shoenfeld
The induction of autoantibodies is common following therapy with anti-TNF-α agents. However, anti-TNF-α-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Also, we searched for similar cases in the published literature. We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation...
October 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29062244/role-of-genetics-in-pediatric-rheumatology
#20
REVIEW
Eda Tahir Turanlı, Elif Everest, Ayşe Balamir, Aslı Kireçtepe Aydın, Özgür Kasapçopur
Pediatric rheumatology includes autoinflammatory monogenic diseases, autoinflammatory multifactorial diseases with complex inheritance, and diseases with uncertain clinical diagnosis or undefined conditions, even though they show signs of autoinflammation. Most of these diseases are systemic; it is important to diagnose patients promptly and definitively and to select proper treatment options based on the diagnoses. Clinical observation and acute-phase responses are usually sufficient for diagnosis; however, genetic analyses can provide supportive data for definite diagnosis and treatment, especially for rare monogenic diseases...
September 2017: Türk Pediatri Arşivi
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