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Ischemic stroke depression cytokine pathway

Miaomiao Jia, Chenxin Li, Ying Zheng, Xiaojing Ding, Meng Chen, Jianhua Ding, Renhong Du, Ming Lu, Gang Hu
Background: Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in major depression, remains unknown. Methods: We used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms...
November 1, 2017: International Journal of Neuropsychopharmacology
Vinh A Nguyen, Leeanne M Carey, Loretta Giummarra, Pierre Faou, Ira Cooke, David W Howells, Tamara Tse, S Lance Macaulay, Henry Ma, Stephen M Davis, Geoffrey A Donnan, Sheila G Crewther
Depression after stroke is a common occurrence, raising questions as to whether depression could be a long-term biological and immunological sequela of stroke. Early explanations for post-stroke depression (PSD) focused on the neuropsychological/psychosocial effects of stroke on mobility and quality of life. However, recent investigations have revealed imbalances of inflammatory cytokine levels in association with PSD, though to date, there is only one published proteomic pathway analysis testing this hypothesis...
2016: Frontiers in Neurology
Shan-Shan Wang, Hai-Ying Chen, Hong Sun, Ting Wang, Jin-Qun Guan
This study was aimed to investigate the changes of the hypothalamic-pituitary-adrenal axis (HPAA) activity and the cytokines system in the hypothalamus of the depressive rats which were exposed to chronic unpredictable mild stressors (CUMS) after middle cerebral artery occlusion (MCAO). By means of qRT-PCR, ELISA and Western blot, mRNA and/or protein expressions of corticotropin releasing factor (CRF), tumor necrosis factors-α (TNF-α), suppressor of cytokines signaling 3 (SOCS3), phosphorylation of signal transducers and activators of transcription 3 (pSTAT3) were measured in the hypothalamus of rats...
August 25, 2014: Sheng Li Xue Bao: [Acta Physiologica Sinica]
W Swardfager, N Herrmann, A C Andreazza, R H Swartz, M M Khan, S E Black, K L Lanctôt
Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum...
2014: BioMed Research International
Jonathan Beaudoin, Robert A Levine, J Luis Guerrero, Chaim Yosefy, Suzanne Sullivan, Susan Abedat, Mark D Handschumacher, Catherine Szymanski, Dan Gilon, Nicholas O Palmeri, Gus J Vlahakes, Roger J Hajjar, Ronen Beeri
BACKGROUND: Ischemic mitral regurgitation (MR) is a frequent complication of myocardial infarction associated with left ventricular (LV) dilatation and dysfunction, which doubles mortality. At the molecular level, moderate ischemic MR is characterized by a biphasic response, with initial compensatory rise in prohypertrophic and antiapoptotic signals, followed by their exhaustion. We have shown that early MR repair 30 days after myocardial infarction is associated with LV reverse remodeling...
September 10, 2013: Circulation
Heidi Ormstad, Robert Verkerk, Hans Christian D Aass, Karl-Friedrich Amthor, Leiv Sandvik
Whether the inflammatory response that accompanies acute ischemic stroke induces the kynurenine pathway is currently a matter of conjecture. Activation of this pathway may disturb active metabolites. The aim of this study was thus to characterize the catabolism of tryptophan and tyrosine in acute ischemic stroke (AIS) patients, and its association with cytokines, C-reactive protein, and glucose. Serum levels of 5-hydroxytryptamine, tryptophan catabolites, and competing amino acids and significant ratios of these were measured in 45 AIS patients and compared to those of 40 control subjects...
November 2013: Journal of Molecular Neuroscience: MN
Karsten Ruscher, Enida Kuric, Yawei Liu, Helene L Walter, Shohreh Issazadeh-Navikas, Elisabet Englund, Tadeusz Wieloch
After stroke, brain inflammation in the ischemic hemisphere hampers brain tissue reorganization and functional recovery. Housing rats in an enriched environment (EE) dramatically improves recovery of lost neurologic functions after experimental stroke. We show here that rats housed in EE after stroke induced by permanent occlusion of the middle cerebral artery (pMCAO), showed attenuated levels of proinflammatory cytokines in the ischemic core and the surrounding peri-infarct area, including a significant reduction in the stroke-induced chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor-1 (CXCL12)...
August 2013: Journal of Cerebral Blood Flow and Metabolism
Kathleen H McDonough, Jitka Ismail Virag
Sepsis, bacteremia and inflammation cause myocardial depression. The mechanism of the dysfunction is not clearly established partly because dysfunction can be elicited by many different mechanisms which can all manifest in disruption of myocardial mechanical function. In addition the models of sepsis and bacteremia and inflammation may vary drastically in the sequence of the coordinated immune response to the inflammatory or septic stimulus. Patterns of cytokine expression can vary as can other responses of the immune system...
January 1, 2006: Frontiers in Bioscience: a Journal and Virtual Library
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