Shuhei Kamada, Hiroki Noguchi, Shota Yamamoto, Kou Tamura, Hidenori Aoki, Asuka Takeda, Maimi Uchishiba, Saki Minato, Moeka Arata, Ryosuke Arakaki, Hiroaki Inui, Tomohiro Kagawa, Takako Kawakita, Atsuko Yoshida, Ayuka Mineda, Yuri Yamamoto, Riyo Kinouchi, Kanako Yoshida, Takashi Kaji, Masato Nishimura, Takeshi Iwasa
Polycystic ovary syndrome (PCOS) is associated with an increased risk of psychological distress as well as enhanced responses to psychosocial stress. Recently, it was hypothesized that PCOS patients may be at high risk of novel COVID-19 infections and worse clinical presentations during such infections. Here, we evaluated the effects of PCOS on stress responses to bacterial and viral mimetics using dihydrotestosterone-induced PCOS model rats. Lipopolysaccharide (LPS; a bacterial mimetic) or polyinosinic-polycytidylic acid (Poly-IC; a viral mimetic) was injected into PCOS model rats (PCOS) and non-PCOS rats (control), and the rats' stress responses were evaluated...
July 2024: Brain, behavior, & immunity health