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Depression cytokine

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https://www.readbyqxmd.com/read/29783087/association-of-t-and-non-t-cell-cytokines-with-anhedonia-role-of-gender-differences
#1
Manish K Jha, Andrew H Miller, Abu Minhajuddin, Madhukar H Trivedi
OBJECTIVE: Among individual depressive symptoms, anhedonia has been reliably associated with activation of the innate immune response. However, it is unclear whether this association extends to T cell cytokines and if gender differentially affects this association. METHOD: Concentrations of T (IL-17, T-helper (Th) 1- and Th2-) and non-T cell cytokines were measured in plasma using the Bioplex Pro™ human cytokine multiplex kit in Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided plasma at baseline (n = 166)...
May 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29782908/deficits-in-temporal-order-memory-induced-by-interferon-alpha-ifn-%C3%AE-treatment-are-rescued-by-aerobic-exercise
#2
Sally Barlow, Briana Fahey, Kimberley J Smith, Johannes Passecker, Andrea Della-Chiesa, Vincent Hok, Jennifer S Day, Charlotte K Callaghan, Shane M O'Mara
Patients receiving cytokine immunotherapy with IFN-α frequently present with neuropsychiatric consequences and cognitive impairments, including a profound depressive-like symptomatology. While the neurobiological substrates of the dysfunction that leads to adverse events in IFN-α-treated patients remains ill-defined, dysfunctions of the hippocampus and prefrontal cortex (PFC) are strong possibilities. To date, hippocampal deficits have been well-characterised; there does however remain a lack of insight into the nature of prefrontal participation...
May 18, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#3
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#4
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29773951/the-role-of-neuroinflammation-and-neurovascular-dysfunction-in-major-depressive-disorder
#5
REVIEW
Sang Won Jeon, Yong-Ku Kim
Although depression has generally been explained with monoamine theory, it is far more multifactorial, and therapies that address the disease's pathway have not been developed. In this context, an understanding of neuroinflammation and neurovascular dysfunction would enable a more comprehensive approach to depression. Inflammation is in a sense a type of allostatic load involving the immune, endocrine, and nervous systems. Neuroinflammation is involved in the pathophysiology of depression by increasing proinflammatory cytokines, activating the hypothalamus-pituitary-adrenal axis, increasing glucocorticoid resistance, and affecting serotonin synthesis and metabolism, neuronal apoptosis and neurogenesis, and neuroplasticity...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29766809/associations-between-depressive-disorders-and-inflammatory-rheumatic-diseases
#6
Ozkan Varan, Hakan Babaoglu, Berna Goker
Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients...
May 15, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29765402/tlr4-nf-%C3%AE%C2%BA-b-signal-involved-in-depressive-like-behaviors-and-cytokine-expression-of-frontal-cortex-and-hippocampus-in-stressed-c57bl-6-and-ob-ob-mice
#7
Yihe Wang, Jingjing Xu, Yuan Liu, Ziyang Li, Xiaohong Li
Studies found that elevated levels of cytokines such as interleukin- (IL-) 1 β , IL-6, and tumor necrosis factor- α (TNF- α ) are closely associated with the pathogenesis of depression. Obesity providing a low-grade inflammation state was proposed to be implicated in susceptibility to depression in obesity. However, the alterations of cytokines and the TLR4-NF- κ B signal in the brain of normal-weight and obese mice under stress have not been fully elucidated. This study used chronic unpredictable mild stress (CUMS) to induce a depressive-like behavior in an animal model and examine depressive-like behaviors, memory changes, and serum corticosterone levels, as well as the expressions of cytokines and NF- κ B in the frontal cortex and hippocampus...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29761778/-the-relation-between-depression-and-inflammation
#8
Lasse Fisker, Ole Köhler-Forsberg, Ida Hageman
Accumulating evidence suggests, that inflammatory processes contribute to the pathophysiology of major depressive disorder. Subgroups of patients have elevated plasma levels of pro-inflammatory cytokines, which seem to normalise in response to conventional antidepressive treatment. In this review of the current studies on the relation between depression and inflammation we discuss possible future directions for individualised treatment of major depressive disorder.
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29759141/elevated-plasma-macrophage-migration-inhibitor-factor-as-a-risk-factor-for-the-development-of-post-stroke-depression-in-ischemic-stroke
#9
Tingting Xu, Shuang Pu, Ying Ni, Mingqing Gao, Xuemei Li, Xianwei Zeng
BACKGROUND: Macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory responses, has been reported to link to the pathophysiology of cardiovascular disease and depression. The aim of this study was to test the possible association between plasma MIF and the development of post-stroke depression (PSD) in Chinese patients with acute ischemic stroke (AIS). METHODS: The first-ever AIS patients who were hospitalized at Affiliated Hospital of Weifang Medical College during the period from November 2015 to September 2017 were included...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29753175/changes-in-the-tryptophan-kynurenine-axis-in-association-to-therapeutic-response-in-clinically-depressed-patients-undergoing-psychiatric-rehabilitation
#10
B Reininghaus, K Riedrich, N Dalkner, S A Bengesser, A Birner, M Platzer, C Hamm, J M Gostner, D Fuchs, E Z Reininghaus
INTRODUCTION: In recent decades a number of studies have shown an association between the Tryptophan (Trp)-Kynurenine (Kyn) axis and neuropsychiatric disorders. However, the role of the Trp-Kyn pathway on the affective status in a general psychiatric cohort requires clarification. This study aimed to measure peripheral changes in Trp, Kyn and the Kyn/Trp-ratio as well as in the inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukine-6 (IL-6) in individuals undergoing a six-week course of intensive treatment program comparing subgroups of treatment responders and non-responders...
May 6, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29752710/inflammation-in-psychiatric-disorders-what-comes-first
#11
REVIEW
Moisés E Bauer, Antonio L Teixeira
Neuropsychiatric disorders (i.e., mood disorders and schizophrenia) and inflammation are closely intertwined, and possibly powering each other in a bidirectional loop. Depression facilitates inflammatory reactions and inflammation promotes depression and other neuropsychiatric disorders. Patients with neuropsychiatric disorders exhibit all cardinal features of inflammation, including increased circulating levels of inflammatory inducers, activated sensors, and inflammatory mediators targeting all tissues. Inflammation may contribute to the pathophysiology and clinical progression of these disorders...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29748196/interleukin-10-treatment-ameliorates-high-fat-diet-induced-inflammatory-atrial-remodeling-and-fibrillation
#12
(no author information available yet)
BACKGROUND: Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29736225/molecular-changes-in-obese-and-depressive-patients-are-similar-to-neurodegenerative-disorders
#13
Laleh Habibi, Abbas Tafakhori, Rasoul Hadiani, Maryam Maserat-Mashhadi, Zeinab Kafrash, Shahla Torabi, Mohammad Azhdarzadeh, Seyed Mohammad Akrami, Morteza Mahmoudi, Rasoul Dinarvand
Background: Neurodegenerative disorders (NDs) are categorized as multifactorial conditions with different molecular and environmental causes. Disturbance of important signaling pathways, such as energy metabolism and inflammation induced by environmental agents, is involved in the pathophysiology of NDs. It has been proposed that changes in the lifestyle and nutrition (metabolism) during mid-life could trigger and accumulate cellular and molecular damages resulting in NDs during aging. Methods: In order to test the hypothesis, we investigated the expression level of two energy metabolism-related [forkhead box O1 (FOXO1) and forkhead box O3 (FOXO3A)] and two pro-inflammatory cytokines [interleukin 1β (IL-1β) and IL-6] genes, using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR)...
October 7, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29734055/kynurenine-pathway-metabolic-balance-influences-microglia-activity-targeting-kynurenine-monooxygenase-to-dampen-neuroinflammation
#14
Allison M Garrison, Jennifer M Parrott, Arnulfo Tuñon, Jennifer Delgado, Laney Redus, Jason C O'Connor
Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors. Microglia regulate KP balance by preferentially producing oxidative metabolites, including quinolinic acid. Research has focused on the interplay between cytokines and HPA axis-derived corticosteroids in regulating microglial activity and effects of KP metabolites directly on neurons; however, the potential role that KP metabolites have directly on microglial activity is unknown...
April 22, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29725904/chronic-mild-stress-alters-kynurenine-pathways-changing-the-glutamate-neurotransmission-in-frontal-cortex-of-rats
#15
David Martín-Hernández, Hiram Tendilla-Beltrán, José L M Madrigal, Borja García-Bueno, Juan C Leza, Javier R Caso
Immune stimulation might be involved in the pathophysiology of major depressive disorder (MDD). This stimulation induces indoleamine 2,3-dioxygenase (IDO), an enzyme that reduces the tryptophan bioavailability to synthesize serotonin. IDO products, kynurenine metabolites, exert neurotoxic/neuroprotective actions through glutamate receptors. Thus, we study elements of these pathways linked to kynurenine metabolite activity examining whether antidepressants (ADs) can modulate them. Male Wistar rats were exposed to chronic mild stress (CMS), and some of them were treated with ADs...
May 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29724678/can-interleukin-2-and-interleukin-1%C3%AE-be-specific-biomarkers-of-negative-symptoms-in-schizophrenia
#16
Leticia González-Blanco, María P García-Portilla, Leticia García-Álvarez, Lorena de la Fuente-Tomás, Celso Iglesias García, Pilar A Sáiz, Susana Rodríguez-González, Ana Coto-Montes, Julio Bobes
INTRODUCTION: Evidence suggests the existence of cytokine disturbances in patients with schizophrenia but their association with psychopathology is still unclear. The aim of the current study was to determine if pro-inflammatory cytokine levels (tumor necrosis factor-α, interleukin (IL)-6, IL-2, IL-1β, IL-1RA) are increased in stable outpatients compared with healthy subjects, and to analyze if they could be specific biomarkers of clinical dimensions in schizophrenia. METHODS: We studied 73 stable outpatients with schizophrenia in their first 10 years of illness and 73 age- and sex-matched healthy controls...
April 30, 2018: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29723656/white-matter-microstructure-alterations-correlate-with-terminally-differentiated-cd8-effector-t-cell-depletion-in-the-peripheral-blood-in-mania-combined-dti-and-immunological-investigation-in-the-different-phases-of-bipolar-disorder
#17
Paola Magioncalda, Matteo Martino, Samuele Tardito, Bruno Sterlini, Benedetta Conio, Valentina Marozzi, Giulia Adavastro, Laura Capobianco, Daniel Russo, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Tiziana Altosole, Niccolò Piaggio, Georg Northoff, Daniela Fenoglio, Matilde Inglese, Gilberto Filaci, Mario Amore
BACKGROUND: White matter (WM) microstructural abnormalities and, independently, signs of immunological activation were consistently demonstrated in bipolar disorder (BD). However, the relationship between WM and immunological alterations as well as their occurrence in the various phases of BD remain unclear. METHOD: In 60 type I BD patients - 20 in manic, 20 in depressive, 20 in euthymic phases - and 20 controls we investigated: (i) diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) using a tract-based spatial statistics (TBSS) approach; (ii) circulating T cell subpopulations frequencies, as well as plasma levels of different cytokines; (iii) potential relationships between WM and immunological data...
April 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29710462/thymelaea-lythroides-extract-attenuates-microglial-activation-and-depressive-like-behavior-in-lps-induced-inflammation-in-adult-male-rats
#18
Inssaf Berkiks, S Boulbaroud, L M Garcia-Segura, A Mesfioui, A Ouichou, S Mouden, H Benmhammed, A El Hasnaoui, R Nakache, Y Bahbiti, A El Hessni
Thymelaea lythroides extract is widely used as a traditional folk medicine in Morocco, especially for the treatment of diabetes, rheumatism and Inflammatory disease. The aim of the study is to evaluate the possible effect of methanolic extract of Thymelaea lythroides in repressing the inflammatory responses and long-lasting depression-like behavior associated with neuroinflammation in adult rats after neonatal LPS exposure. Male rat pups were treated systemically with either LPS (250??g/kg) or vehicle (phosphate buffer saline) on postnatal day 14...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705851/mouse-testing-methods-in-psychoneuroimmunology-2-0-measuring-behavioral-responses
#19
Albert E Towers, Jason M York, Tracy Baynard, Stephen J Gainey, Gregory G Freund
The field of psychoneuroimmunology (PNI) aims to uncover the processes and consequences of nervous, immune, and endocrine system relationships. Behavior is a consequence of such interactions and manifests from a complex interweave of factors including immune-to-neural and neural-to-immune communication. Often the signaling molecules involved during a particular episode of neuroimmune activation are not known but behavioral response provides evidence that bioactives such as neurotransmitters and cytokines are perturbed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29705847/neuroimmune-mechanisms-of-depression-in-adults-with-heart-failure
#20
Jessica A Jiménez, Christine Tara Peterson, Paul J Mills
Heart failure (HF) is a major and costly public health concern, and its prognosis is grim-with high hospitalization and mortality rates. HF affects millions of individuals across the world, and this condition is expected to become "the epidemic" of the twenty-first century (Jessup et al., 2016). It is well documented that individuals with HF experience disproportionately high rates of depression and that those who are depressed have worse clinical outcomes than their nondepressed counterparts. The purpose of this chapter is to introduce the reader to the study of depression in HF, and how psychoneuroimmunologic principles have been applied to further elucidate mechanisms (i...
2018: Methods in Molecular Biology
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