Roger Espinosa-Saez, Sara M Robledo, Tatiana Pineda, Javier Murillo, César Zúñiga, Osvaldo Yañez, Plinio Cantero-López, Alex Saez-Vega, Camilo Guzmán-Teran
In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity and druggability were tested in vitro and in silico, respectively, observing as a result: firstly, compounds showed half-maximal effective concentration (EC50 ) values between 3.6 and 19.3 µM. Likewise, a treatment using the compounds 4a-f caused improvement in most of the treated hamsters and cured some of them. Regarding the antiplasmodial activity, the compounds showed moderate to high activity, although they did not show hemolytic activity...
October 16, 2023: Scientific Reports