keyword
https://read.qxmd.com/read/37845281/screening-of-the-antileishmanial-and-antiplasmodial-potential-of-synthetic-2-arylquinoline-analogs
#1
JOURNAL ARTICLE
Roger Espinosa-Saez, Sara M Robledo, Tatiana Pineda, Javier Murillo, César Zúñiga, Osvaldo Yañez, Plinio Cantero-López, Alex Saez-Vega, Camilo Guzmán-Teran
In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity and druggability were tested in vitro and in silico, respectively, observing as a result: firstly, compounds showed half-maximal effective concentration (EC50 ) values between 3.6 and 19.3 µM. Likewise, a treatment using the compounds 4a-f caused improvement in most of the treated hamsters and cured some of them. Regarding the antiplasmodial activity, the compounds showed moderate to high activity, although they did not show hemolytic activity...
October 16, 2023: Scientific Reports
https://read.qxmd.com/read/37511195/a-comparative-analysis-of-neuroprotective-properties-of-taxifolin-and-its-water-soluble-form-in-ischemia-of-cerebral-cortical-cells-of-the-mouse
#2
JOURNAL ARTICLE
Elena G Varlamova, Nina I Uspalenko, Natalia V Khmil, Maria I Shigaeva, Mikhail R Stepanov, Mikhail A Ananyan, Maria A Timchenko, Maxim V Molchanov, Galina D Mironova, Egor A Turovsky
Cerebral ischemia, and, as a result, insult, attacks up to 15 million people yearly in the world. In this connection, the development of effective preventive programs and methods of therapy has become one of the most urgent problems in modern angiology and pharmacology. The cytoprotective action of taxifolin (TAX) in ischemia is well known, but its limitations are also known due to its poor solubility and low capacity to pass through the hematoencephalic barrier. Molecular mechanisms underlying the protective effect of TAX in complex systems such as the brain remain poorly understood...
July 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36224037/cns-tumors-clinical-and-radiological-aspects
#3
JOURNAL ARTICLE
Renata Emmerová, Jana Engelová, Stěpan Vinakurau, Barbora Ondrová
Tumors of the central nervous system (CNS) include primary tumors - itraaxial, growing from brain and spinal cord cells (neuroepithelial tumors) or extraaxial, growing from surrounding structures (brain and spinal cord, nerve sheaths, vascular structures, lymphatic tissue, germ cells, malformations, pituitary glands). Much more often they are located in the intracranial space a solitary or multiple metastatic spread of malignancy originating from another organ (eg lung, breast, malignant melanoma, Grawitzs tumor)...
2022: Ceskoslovenská Patologie
https://read.qxmd.com/read/35749597/hematosalivarian-barrier-structure-functions-study-methods-review-of-literature
#4
REVIEW
Inna Alexandrovna Selezneva, F N Gilmiyarova, V S Tlustenko, D A Domenjuk, O A Gusyakova, N A Kolotyeva, I E Gilmiyarova, I A Nazarkina
The human body consists of various systems (blood, tissues, extracellular fluid, intracellular contents) separated by biological membranes. Physiological barriers ensure the physico-chemical composition of the internal environment remains constant and protects the body from environmental changes. The permeability of the histohematic barrier depends on the concentration of substances in the blood, the body's condition, external influences, and a number of other reasons caused by stimuli coming from the external or internal environment...
June 20, 2022: Klinicheskaia Laboratornaia Diagnostika
https://read.qxmd.com/read/35488996/fluoride-induced-neurobehavioral-impairments-in-experimental-animals-a-brief-review
#5
REVIEW
Harsheema Ottappilakkil, Srija Babu, Satheeswaran Balasubramanian, Suryaa Manoharan, Ekambaram Perumal
Fluoride is one of the major toxicants in the environment and is often found in drinking water at higher concentrations. Living organisms including humans exposed to high fluoride levels are found to develop mild-to-severe detrimental pathological conditions called fluorosis. Fluoride can cross the hematoencephalic barrier and settle in various brain regions. This accumulation affects the structure and function of both the central and peripheral nervous systems. The neural ultrastructure damages are reflected in metabolic and cognitive activities...
April 30, 2022: Biological Trace Element Research
https://read.qxmd.com/read/32708613/proteome-of-glioblastoma-derived-exosomes-as-a-source-of-biomarkers
#6
JOURNAL ARTICLE
Stanislav Naryzhny, Andrey Volnitskiy, Arthur Kopylov, Elena Zorina, Roman Kamyshinsky, Viktor Bairamukov, Luiza Garaeva, Anatoly Shlikht, Tatiana Shtam
Extracellular vesicles (EV) are involved in important processes of glioblastoma multiforme (GBM), including malignancy and invasion. EV secreted by glioblastoma cells may cross the hematoencephalic barrier and carry molecular cargo derived from the tumor into the peripheral circulation. Therefore, the determination of the molecular composition of exosomes released by glioblastoma cells seems to be a promising approach for the development of non-invasive methods of the detection of the specific exosomal protein markers in the peripheral blood...
July 16, 2020: Biomedicines
https://read.qxmd.com/read/30537520/diabetes-induced-neuropathic-mechanical-hyperalgesia-depends-on-p2x4-receptor-activation-in-dorsal-root-ganglia
#7
JOURNAL ARTICLE
Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Amanda Ferreira Neves, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Catarine Massucato Nishijima, Felipe Hertzing Farias, Jozi Godoy Figueiredo, Victor Hernandez-Olmos, Samer Alshaibani, Cláudia Herrera Tambeli, Christa E Müller, Carlos Amílcar Parada
Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. However, there is an open question: Is P2X4R activation on dorsal root ganglia (DRG) involved in the development of neuropathic pain? To answer this question, this study verified the involvement of P2X4R expressed in DRG cells on diabetes-induced neuropathic mechanical hyperalgesia in rats...
February 1, 2019: Neuroscience
https://read.qxmd.com/read/27512514/pulmonary-eosinophilia-associated-to-treatment-with-natalizumab
#8
Elena Curto, Elvira Munteis-Olivas, Eva Balcells, M Marisol Domínguez-Álvarez
Natalizumab (Tysabri(®)) is a leukocytes chemotaxis inhibitor that decreases the leukocytes passage through the hematoencephalic barrier and it is currently used in relapsing-remitting forms of multiple sclerosis (MS). We present a patient with allergic rhinoconjunctivitis diagnosed with MS who started treatment with natalizumab. She began to show mild asthmatic symptoms until she needed admission to the hospital due to respiratory insufficiency. Blood tests showed peripheral eosinophilia and the thoracic computed tomography scan demonstrated pulmonary infiltrates...
2016: Annals of Thoracic Medicine
https://read.qxmd.com/read/27349210/dialysis-headache-a-narrative-review
#9
REVIEW
Eduardo Sousa Melo, Filipe Carrilho Aguiar, Pedro Augusto Sampaio Rocha-Filho
BACKGROUND: Patients with chronic kidney disease who need dialysis often have poor quality of life. Dialysis headache is a frequent complication of hemodialysis and is often a challenge for nephrologists, neurologists, and headache specialists. METHOD: This was a narrative review. RESULTS: The prevalence of dialysis headache varies between 27% and 73%. Among the characteristics of this headache are the pulsatile pattern, frontal location, moderate to severe intensity, and onset a few hours after the beginning of dialysis...
January 2017: Headache
https://read.qxmd.com/read/26856078/-reaction-of-structural-elements-of-hematoencephalic-barrier-in-newborn-rats-to-normobaric-hypoxia
#10
JOURNAL ARTICLE
V A Otellin, L I Khozhai, T T Shishko
For the last time a particular interest of investigators has been attracted to the period of early newborn state when active process of adaptation of the organism to new life conditions occur defining its increased sensitivity to the effect of unfavorable environmental factors. An important place among these processes belongs to formation of homeostasis mechanisms and, primarily, the barrier mechanisms. The purpose of the present study was to investigate reactions of the hematoencephalic barrier (HEB) to action of perinatal normobaric hypoxia (a model of incomplete human pregnancy)...
September 2015: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://read.qxmd.com/read/25080783/-the-different-notions-about-beta-oxidation-of-fatty-acids-in-peroxisomes-peroxisomes-and-ketonic-bodies-the-diabetic-acidotic-coma-as-an-acute-deficiency-of-acetyl-coa-and-atp
#11
REVIEW
T I Kotkina, V N Titov, R M Parkhimovich
The mechanisms of beta-oxidation of fatty acids developed more than a century before have no compliance with actual physical chemical data. The oxidation of long-chain C 16:0 palmitic saturated fatty acid occurs not by sequential formation of eight molecules of acetyl-KoA but by force of formation of double bond and its hydrolysis on two short-chain C 8:0 fatty acids. Only short-chain fatty acids can become shorter under "chipping" of C 2-acetate with formation of C 4-butyric acid (butyrate) and its metabolites (beta-hidroxibutirate, acetoacetate, acetone)...
March 2014: Klinicheskaia Laboratornaia Diagnostika
https://read.qxmd.com/read/24861123/-crigler-najjar-syndrome-report-of-one-case-with-a-long-term-follow-up
#12
JOURNAL ARTICLE
Santiago Besa, Carlos I Calvo, Paul R Harris
Crigler-Najjar Syndrome is an uncommon genetic disorder characterized by the elevation of unconjugated plasmatic bilirubin secondary to deficiency of the enzyme uridine diphosphate glucuronyltransferase (UDP-GT). We report a 19-years-old woman with the syndrome diagnosed during the neonatal period, when she developed a severe jaundice in the first 10 days of life, reaching unconjugated bilirubin levels of 29 mg/dl, with normal liver function tests. After transient response to phototherapy, the patient was referred to a tertiary medical center in which an extensive work up ruled out other etiologies and the diagnosis of type I Crigler-Najjar syndrome was established...
January 2014: Revista Médica de Chile
https://read.qxmd.com/read/24672892/antihistamines-in-drivers-aircrew-and-occupations-of-risk
#13
JOURNAL ARTICLE
I Jáuregui, M Ferrer, J Montoro, I Dávila, J Bartra, A del Cuvillo, J Mullol, J Sastre, A Valero
The most commonly occurring allergic diseases can involve a daytime drowsiness associated with the condition itself. The antihistamines used in their treatment can also have central effects and affect certain occupations concerned with risk, road safety and maritime and air navigation. Cognitive tests, experimental studies and epidemiological data recommend avoiding 1st generation antihistamines for people who must drive regularly and/or professions concerned with safety. Although there are no comparative studies on real driving between 1st and 2nd generation antihistamines, in this type of patients there should be a preference for prescribing those with least possible central effect, especially those which are a good substrate for transmembrane transporter pumps such as P-glycoprotein and therefore have a low capacity for crossing the hematoencephalic barrier, thus allowing a broader window for therapy...
2013: Journal of Investigational Allergology & Clinical Immunology
https://read.qxmd.com/read/24672891/h1-antihistamines-and-benzodiazepines-pharmacological-interactions-and-their-impact-on-cerebral-function
#14
REVIEW
J Montoro, J Bartra, J Sastre, I Dávila, M Ferrer, J Mullol, A del Cuvillo, I Jáuregui, A Valero
Antihistamines (AH) have been classified into first and second generation according to their pharmacokinetic properties, structural characteristics and adverse effects. The effects on the central nervous system (CNS) are determined basically by their capacity to cross the hematoencephalic barrier and attach to central H1 receptors. Benzodiazepines (BZD) are drugs with effects on the CNS following their union to the specific location of GABA receptors type A. At low doses, the BZD have sedative and anticonvulsive effects, and as the dose increases it leads to sedation, amnesia and finally unconsciousness...
2013: Journal of Investigational Allergology & Clinical Immunology
https://read.qxmd.com/read/24307938/transfer-of-silver-nanoparticles-through-the-placenta-and-breast-milk-during-in-vivo-experiments-on-rats
#15
JOURNAL ARTICLE
E A Melnik, Yu P Buzulukov, V F Demin, V A Demin, I V Gmoshinski, N V Tyshko, V A Tutelyan
Silver nanoparticles (NPs), widely used in the manufacture of various types of consumer products and for medical applications, belong to novel types of materials that pose potential risks to human health. The potential negative effects of the influence of these NPs on reproduction are insufficiently researched. A quantitative assessment of the transfer of metallic silver nanoparticles through the placenta and breast milk was carried out during an in vivo experiment. We used 34.9 ± 14.8 nm in size silver NPs that were stabilized by low-molecularweight polyvinylpyrrolidone and labeled with the (110m)Ag radioactive isotope using thermal neutron irradiation in a nuclear reactor...
July 2013: Acta Naturae
https://read.qxmd.com/read/23916150/nmr-determination-of-electrophorus-electricus-acetylcholinesterase-inhibition-and-reactivation-by-neutral-oximes
#16
JOURNAL ARTICLE
Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villar
Neurotoxic organophosphorus compounds (OPs), which are used as pesticides and chemical warfare agents lead to more than 700,000 intoxications worldwide every year. The main target of OPs is the inhibition of acetylcholinesterase (AChE), an enzyme necessary for the control of the neurotransmitter acetylcholine (ACh). The control of ACh function is performed by its hydrolysis with AChE, a process that can be completely interrupted by inhibition of the enzyme by phosphylation with OPs. Compounds used for reactivation of the phosphylated AChE are cationic oximes, which usually possess low membrane and hematoencephalic barrier permeation...
September 15, 2013: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/23814823/-permeability-of-the-hematoencephalic-barrier-in-normalcy-brain-development-pathology-and-neurodegeneration
#17
REVIEW
N V Kuvacheva, A B Salmina, Yu K Komleva, N A Malinovskaya, A V Morgun, E A Pozhilenkova, G S Zamai, N A Yauzina, M M Petrova
No abstract text is available yet for this article.
2013: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/23805681/-intestinal-brain-axis-neuronal-and-immune-inflammatory-mechanisms-of-brain-and-intestine-pathology
#18
REVIEW
V M Bondarenko, E V Riabichenko
Mutually directed connections between intestine and brain are implemented by endocrine, neural and immune systems and nonspecific natural immunity. Intestine micro flora as an active participant of intestine-brain axis not only influences intestine functions but also stimulates the development of CNS in perinatal period and interacts with higher nervous centers causing depression and cognitive disorders in pathology. A special role belongs to intestine microglia. Apart from mechanic (protective) and trophic functions for intestine neurons, glia implements neurotransmitter, immunologic, barrier and motoric functions in the intestine...
2013: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://read.qxmd.com/read/23432076/-nanopathology-as-a-new-scientific-discipline-minireview
#19
REVIEW
Jana Dvořáčková, Hana Bielniková, Jirka Mačák
The detection of metal particles in the pathologically altered tissues (eg. in inflammatory lesions or tumors) led to the idea that they might be associated with emergence of some idiopathic diseases. To understand the etiopathogenesis of diseases associated with the presence of nanoparticles in the tissue there is a new area of pathology - nanopathology. Numerous studies have shown that nanoparticles can enter the human body through inhalation or ingestion. Through the pulmonary alveoli, skin and intestinal mucosa, the nanoparticles may reach the blood and lymphatic system, which subsequently distributes them to other target organs...
January 2013: Ceskoslovenská Patologie
https://read.qxmd.com/read/23166992/-fundamental-and-applied-aspects-of-the-hematoencephalic-barrier-research
#20
REVIEW
V P Chekhonin, V P Baklaushev, G M Iusubalieva, N E Volgina, O I Gurina
The results of fundamental and applied studies of blood-brain barrier had been conducted by authors during the last 10 years are summarized in the publication. The molecular anatomy of barrier microvessels, as well as promising markers of BBB and other proteins involved in barrier functions are discussed. Via in vitro experiments with endothelial cells of cerebral microvessels we characterized the basic conditions required for adequate BBB modeling. The in vivo data of BBB permeability for macromolecules in normal and different pathological process is including radiation injury, hyperosmotic shock, and nervous tissue ischemia are properly described...
2012: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
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