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Babak Banan

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https://www.readbyqxmd.com/read/27331362/attenuation-of-ischemia-reperfusion-injury-and-improvement-of-survival-in-recipients-of-steatotic-rat-livers-using-cd47-monoclonal-antibody
#1
Zhenyu Xiao, Babak Banan, Min Xu, Jianluo Jia, Pamela T Manning, Ronald R Hiebsch, Muthukumar Gunasekaran, Gundumi A Upadhya, William A Frazier, Thalachallour Mohanakumar, Yiing Lin, William C Chapman
BACKGROUND: Despite the efficacy of orthotopic liver transplantation in the treatment of end-stage liver diseases, its therapeutic utility is severely limited by the availability of donor organs. The ability to rehabilitate marginal organs, such as steatotic allografts, has the potential to address some of the supply limitations of available organs for transplantation. Steatotic livers are more susceptible to ischemia-reperfusion injury (IRI), which is exacerbated by the thrombospondin-1/CD47 pathway through inhibition of nitric oxide signaling...
July 2016: Transplantation
https://www.readbyqxmd.com/read/27027254/development-of-a-normothermic-extracorporeal-liver-perfusion-system-toward-improving-viability-and-function-of-human-extended-criteria-donor-livers
#2
Babak Banan, Rao Watson, Min Xu, Yiing Lin, William Chapman
Donor organ shortages have led to an increased interest in finding new approaches to recover organs from extended criteria donors (ECD). Normothermic extracorporeal liver perfusion (NELP) has been proposed as a superior preservation method to reduce ischemia/reperfusion injury (IRI), precondition suboptimal grafts, and treat ECD livers so that they can be successfully used for transplantation. The aim of this study was to investigate the beneficial effects of a modified NELP circuit on discarded human livers...
July 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26439190/novel-strategy-to-decrease-reperfusion-injuries-and-improve-function-of-cold-preserved-livers-using-normothermic-ex-vivo-liver-perfusion-machine
#3
Babak Banan, Zhenyu Xiao, Rao Watson, Min Xu, Jianluo Jia, Gundumi A Upadhya, Thalachallour Mohanakumar, Yiing Lin, William Chapman
Normothermic extracorporeal liver perfusion (NELP) can decrease ischemia/reperfusion injury to the greatest degree when cold ischemia time is minimized. Warm perfusion of cold-stored livers results in hepatocellular damage, sinusoidal endothelial cell (SEC) dysfunction, and Kupffer cell activation. However, the logistics of organ procurement mandates a period of cold preservation before NELP. The aim of this study was to determine the beneficial effects of gradual rewarming of cold-stored livers by placement on NELP...
March 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26294088/normothermic-extracorporeal-liver-perfusion-for-donation-after-cardiac-death-dcd-livers
#4
COMPARATIVE STUDY
Babak Banan, Haniee Chung, Zhenyu Xiao, Yaman Tarabishy, Jianluo Jia, Pamela Manning, G A Upadhya, Thalachallour Mohanakumar, Yiing Lin, William C Chapman
BACKGROUND: The susceptibility of extended criteria livers to ischemia reperfusion injury is a major obstacle in organ cold preservation. Normothermic extracorporeal liver perfusion (NELP) has been investigated to reduce ischemic damage, restore physiologic function, and assess viability of the liver prior to transplant. The goal of this study is to compare physiological parameters of livers maintained continuously on NELP to those preserved in cold solution. METHODS: Livers from 9 female landrace pigs were subjected to either 20 minutes (W20-NELP), 40 minutes (W40-NELP), or 60 minutes (W60-NELP) of warm ischemia followed by 6 hours of NELP followed by a 2-hour NELP evaluation phase...
December 2015: Surgery
https://www.readbyqxmd.com/read/25721088/antibody-mediated-therapy-targeting-cd47-inhibits-tumor-progression-of-hepatocellular-carcinoma
#5
Zhenyu Xiao, Haniee Chung, Babak Banan, Pamela T Manning, Katherine C Ott, Shin Lin, Benjamin J Capoccia, Vijay Subramanian, Ronald R Hiebsch, Gundumi A Upadhya, Thalachallour Mohanakumar, William A Frazier, Yiing Lin, William C Chapman
Human hepatocellular carcinoma (HCC) has a high rate of tumor recurrence and metastasis, resulting in shortened survival times. The efficacy of current systemic therapies for HCC is limited. In this study, we used xenograft tumor models to investigate the use of antibodies that block CD47 and inhibit HCC tumor growth. Immunostaining of tumor tissue and HCC cell lines demonstrated CD47 over-expression in HCC as compared to normal hepatocytes. Macrophage phagocytosis of HCC cells was increased after treatment with CD47 antibodies (CD47mAbs) that block CD47 binding to SIRPα...
May 1, 2015: Cancer Letters
https://www.readbyqxmd.com/read/25482981/cd47-blockade-reduces-ischemia-reperfusion-injury-and-improves-survival-in-a-rat-liver-transplantation-model
#6
Zhen-Yu Xiao, Babak Banan, Jianluo Jia, Pamela T Manning, Ronald R Hiebsch, Muthukumar Gunasekaran, Gundumi A Upadhya, William A Frazier, Thalachallour Mohanakumar, Yiing Lin, William C Chapman
Orthotopic liver transplantation (OLT) remains the standard treatment option for nonresponsive liver failure. Because ischemia/reperfusion injury (IRI) is an important impediment to the success of OLT, new therapeutic strategies are needed to reduce IRI. We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Syngeneic OLT was performed with Lewis rats. Control immunoglobulin G or CD47mAb400 was administered to the donor organ at procurement or to both the organ and the recipient at the time of transplant...
April 2015: Liver Transplantation
https://www.readbyqxmd.com/read/25467797/synergistic-effect-of-pro-inflammatory-tnf%C3%AE-and-il-17-in-periostin-mediated-collagen-deposition-potential-role-in-liver-fibrosis
#7
Suneetha Amara, Karina Lopez, Babak Banan, Sade-Kemi Brown, Margaret Whalen, Elbert Myles, Michael T Ivy, Terrance Johnson, Kevin L Schey, Venkataswarup Tiriveedhi
BACKGROUND: The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin. METHODS: HepG2 cells were cultured and treated with inflammatory cytokines, TNFα and IL-17. Computational promoter sequence analysis of the periostin promoter was performed to define the putative binding sites for transcription factors...
March 2015: Molecular Immunology
https://www.readbyqxmd.com/read/25095525/role-of-alloimmunity-and-autoimmunity-in-allograft-rejection
#8
Babak Banan, Zhongping Xu, Muthukumar Gunasekaran, T Mohanakumar
Pathophysiology of chronic rejection strongly supports that inflammation and subsequent tissue remodeling during the post-transplant period cause exposure of cryptic self-antigens (SAgs) or their determinants within the graft, which, along with a subsequent cytokine response, leads to loss of peripheral tolerance. These events lead to the activation of cell-mediated immunity towards development of de novo immune responses to SAgs. There is also evidence for a role for interplay between allo- and autoimmunity in the development of chronic rejection...
2013: Clinical Transplants
https://www.readbyqxmd.com/read/24380698/role-of-defensins-in-the-pathogenesis-of-chronic-lung-allograft-rejection
#9
Venkataswarup Tiriveedhi, Babak Banan, Saini Deepti, Angaswamy Nataraju, Ramsey Hachem, Elbert Trulock, Patterson G Alexander, Mohanakumar Thalachallour
Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still remains a major problem affecting long-term outcomes in human lung transplantation (LTx). Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been associated with the development of BOS. This study determines the role of defensins, produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of airway inflammation and fibrosis which are characteristic hallmarks of BOS...
April 2014: Human Immunology
https://www.readbyqxmd.com/read/24036218/synergism-of-a-natural-plant-product-oleanolic-acid-with-calcineurin-inhibitor-in-prolonging-islet-allograft-survival
#10
Nataraju Angaswamy, Venkatswarup Tiriveedhi, Babak Banan, Nicholas Benshoff, William Chapman, T Mohanakumar
BACKGROUND: Oleanolic acid (OA) is a natural plant-derived triterpenoid with potent anti-inflammatory properties. Since inflammatory cytokines released following islet transplantation hinders engraftment and long-term function, we determined the synergistic ability of OA to with Cyclosporine-A (CSA), a calcineurin inhibitor in improving islet allograft's function and survival. METHODS: C57BL/6 mice were rendered diabetic using streptozotocin (200mg/kg). BALB/c islets were transplanted under the kidney capsule alone (control) or along with administration of OA alone, CSA alone or a combination of both OA and CSA (OA+CSA)...
December 2013: Transplant Immunology
https://www.readbyqxmd.com/read/19937416/clinical-endoscopic-and-pathologic-spectrum-of-non-steroidal-anti-inflammatory-drug-induced-colitis
#11
Bita Geramizadeh, Alireza Taghavi, Babak Banan
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of arthritis and many other painful conditions. These drugs may cause damage not only to the upper gastrointestinal tract but also to the small and large intestine. This prospective study aimed to determine the presence of colonic lesions among 24 patients who were receiving NSAIDs for more than 3 months, and presented with diarrhea, intractable abdominal pain, and lower GI bleeding. Colonoscopy was done and multiple biopsies from different sites in the colon were obtained...
July 2009: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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