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https://www.readbyqxmd.com/read/28340506/neuromedin-u-alters-bioenergetics-and-expands-the-cancer-stem-cell-phenotype-in-her2-positive-breast-cancer
#1
Vanesa G Martinez, John Crown, Richard K Porter, Lorraine O'Driscoll
Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients, although the mechanism through which it exerts this effect remained unexplained. Investigating this, here we found that ectopic over-expression of NmU in HER2-positive breast cancer cells induced aberrant metabolism, with increased glycolysis, likely due to enhanced pyruvate dehydrogenase kinase activity...
March 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28339587/incisor-inclination-and-perceived-tooth-colour-changes
#2
Philip Ciucchi, Stavros Kiliaridis
Introduction: Social attractiveness is influenced by a variety of different smile-related factors. We evaluated whether the degree of upper central incisor proclination can result in tooth colour change. Methods: Forty young adult subjects (20-25 years) in good health with a complete sound dentition were selected. The subjects were seated in standardized light conditions with an above-directed light source. Their natural head position was stated as 0 degrees. To mimic the range of possible anterior torque movements they were asked to tilt their heads upward +15 degrees (upward tilting) and downward -15 degrees (downward tilting)...
January 25, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28338978/isotope-signals-and-anatomical-features-in-tree-rings-suggest-a-role-for-hydraulic-strategies-in-diffuse-drought-induced-die-back-of-pinus-nigra
#3
Laura Petrucco, Andrea Nardini, Georg von Arx, Matthias Saurer, Paolo Cherubini
The 2003 and 2012 summer seasons were among the warmest and driest of the last 200 years over southeastern Europe, and in particular in the Karst region (northeastern Italy). Starting from winter-spring 2013, several black pines (Pinus nigra J.F. Arnold) suffered crown die-back. Declining trees occurred nearby individuals with no signs of die-back, raising hypotheses about the occurrence of individual-specific hydraulic strategies underlying different responses to extreme drought. We investigated possible processes driving black pine decline by dendrochronological and wood anatomical measurements, coupled with analysis of tree-ring carbon (δ13C) and oxygen (δ18O) isotopic composition in healthy trees (H) and trees suffering die-back (D)...
March 17, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338720/from-teeth-to-baleen-and-raptorial-to-bulk-filter-feeding-in-mysticete-cetaceans-the-role-of-paleontological-genetic-and-geochemical-data-in-feeding-evolution-and-ecology
#4
Annalisa Berta, Agnese Lanzetti, Eric G Ekdale, Thomas A Deméré
The origin of baleen and filter feeding in mysticete cetaceans occurred sometime between approximately 34 and 24 million years ago and represents a major macroevolutionary shift in cetacean morphology (teeth to baleen) and ecology (raptorial to filter feeding). We explore this dramatic change in feeding strategy by employing a diversity of tools and approaches: morphology, molecules, development, and stable isotopes from the geological record. Adaptations for raptorial feeding in extinct toothed mysticetes provide the phylogenetic context for evaluating morphological apomorphies preserved in the skeletons of stem and crown edentulous mysticetes...
December 16, 2016: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28337417/skeletal-and-dentoalveolar-changes-after-miniscrew-assisted-rapid-palatal-expansion-in-young-adults-a-cone-beam-computed-tomography-study
#5
Jung Jin Park, Young-Chel Park, Kee-Joon Lee, Jung-Yul Cha, Ji Hyun Tahk, Yoon Jeong Choi
OBJECTIVE: The aim of this study was to evaluate the skeletal and dentoalveolar changes after miniscrew-assisted rapid palatal expansion (MARPE) in young adults by cone-beam computed tomography (CBCT). METHODS: This retrospective study included 14 patients (mean age, 20.1 years; range, 16-26 years) with maxillary transverse deficiency treated with MARPE. Skeletal and dentoalveolar changes were evaluated using CBCT images acquired before and after expansion. Statistical analyses were performed using paired t-test or Wilcoxon signed-rank test according to normality of the data...
March 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28337015/natural-tooth-preservation-versus-extraction-and-implant-placement-patient-preferences-and-analysis-of-the-willingness-to-pay
#6
D Re, C Ceci, F Cerutti, M Del Fabbro, S Corbella, S Taschieri
Objectives The aim of this study was to evaluate the patients' willingness to pay (WTP) values and preference for the treatment of a tooth with very poor prognosis, among two options: root canal therapy and crown positioning or tooth extraction, implant insertion and crown positioning.Methods A total of 103 patients were recruited from a private dental clinic and interviewed. A questionnaire measured individuals' preferences among the two alternative treatments for a tooth with poor prognosis and the maximum amount of money they would be willing to pay for their choice with a starting bid of [euro]2,000 in [euro]100 increment/decrement...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28337012/preparedness-of-undergraduate-dental-students-in-the-united-kingdom-a-national-study
#7
K Ali, A Slade, E Kay, D Zahra, C Tredwin
Aims To evaluate the self-perceived preparedness of final year dental undergraduate students in the United Kingdom.Methods Dental undergraduate students in their final year were invited by email through the Dental Schools Council (DSC) to provide their responses to an online preparedness assessment scale. The data analysis was carried out using the RUMM2030 software which is specifically designed for Rasch analysis, a measurement model based on item response theory.Results Students felt adequately prepared to carry out simple clinical procedures and communication skills...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28336976/the-hall-technique-10-years-on-questions-and-answers
#8
N P T Innes, D J P Evans, C C Bonifacio, M Geneser, D Hesse, M Heimer, M Kanellis, V Machiulskiene, J Narbutaité, I C Olegário, A Owais, M P Araujo, D P Raggio, C Splieth, E van Amerongen, K Weber-Gasparoni, R M Santamaria
It is ten years since the first paper on the Hall Technique was published in the British Dental Journal and almost 20 years since the technique first came to notice. Dr Norna Hall a (now retired) general dental practitioner from the north of Scotland had, for many years, been managing carious primary molar teeth by cementing preformed metal crowns over them, with no local anaesthesia, tooth preparation or carious tissue removal. This first report, a retrospective analysis of Dr Hall's treatments, caused controversy...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28336877/lipoic-acid-gold-nanoparticles-functionalized-with-organic-compounds-as-bioactive-materials
#9
Ioana Turcu, Irina Zarafu, Marcela Popa, Mariana Carmen Chifiriuc, Coralia Bleotu, Daniela Culita, Corneliu Ghica, Petre Ionita
Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization...
February 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336787/probabilistic-divergence-time-estimation-without-branch-lengths-dating-the-origins-of-dinosaurs-avian-flight-and-crown-birds
#10
G T Lloyd, D W Bapst, M Friedman, K E Davis
Branch lengths-measured in character changes-are an essential requirement of clock-based divergence estimation, regardless of whether the fossil calibrations used represent nodes or tips. However, a separate set of divergence time approaches are typically used to date palaeontological trees, which may lack such branch lengths. Among these methods, sophisticated probabilistic approaches have recently emerged, in contrast with simpler algorithms relying on minimum node ages. Here, using a novel phylogenetic hypothesis for Mesozoic dinosaurs, we apply two such approaches to estimate divergence times for: (i) Dinosauria, (ii) Avialae (the earliest birds) and (iii) Neornithes (crown birds)...
November 2016: Biology Letters
https://www.readbyqxmd.com/read/28334058/benchmarking-outcomes-in-implant-prosthodontics-partial-fixed-dental-prostheses-and-crowns-supported-by-implants-with-a-turned-surface-over-10-to-28-years-at-the-university-of-toronto
#11
Asbjørn Jokstad, Anne M Gussgard, Joseph Fava, Mark Lin, Babak Shokati, Eszter Somogyi-Ganss, Brenton Winnett, Mohammed Zahran
PURPOSE: The aim of this noninterventional, retrospective study was to benchmark the outcomes of patients with partial fixed prostheses supported by implants treated at the University of Toronto at least 10 years earlier. A study protocol for assessing outcomes on like patients developed at the University of Bern, Switzerland, was followed. MATERIALS AND METHODS: All patients who had received at least one implant before 2002 were considered eligible to be included in the study (n = 298)...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28334057/esthetic-and-patient-centered-outcomes-of-single-implants-a-retrospective-study
#12
Björn Gjelvold, Bruno Ramos Chrcanovic, Ingrid Collin Bagewitz, Jenö Kisch, Tomas Albrektsson, Ann Wennerberg
PURPOSE: The aims of this clinical study were to retrospectively evaluate implant survival, patient satisfaction, and radiographic, clinical, and esthetic outcomes following single-implant treatment. MATERIALS AND METHODS: Eighty-seven patients, with a total of 126 implants (XiVE S, Dentsply Implants), who received single implant-retained crowns between 2004 and 2011 were retrospectively evaluated. Implant survival, marginal bone levels (MBL), changes in implant/mesial tooth vertical relationship, pink esthetic score (PES), white esthetic score (WES), patient assessment of the esthetics (visual analog scale), and oral health impact profile (OHIP-14) were evaluated...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28334055/the-effect-of-coded-healing-abutments-on-treatment-duration-and-clinical-outcome-a-randomized-controlled-clinical-trial-comparing-encode-and-conventional-impression-protocols
#13
Jaafar Abduo, Chen Chen, Eugene Le Breton, Alexandra Radu, Josephine Szeto, Roy Judge, Ivan Darby
PURPOSE: To compare the Encode impression protocol (Biomet 3i) with the conventional impression protocol in terms of treatment duration, clinical accuracy, and outcome up to the first postplacement review of single-implant crowns. MATERIALS AND METHODS: A total of 45 implants were included in this study. The implants were randomly allocated to the Encode group (23 implants) or the conventional group (22 implants). At the time of surgery, all implants received two-piece Encode healing abutments...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28327883/chapiniella-variabilis-nematoda-parasitizing-chelonoidis-carbonarius-and-c-denticulatus-testudinidae-in-the-state-of-piau%C3%A3
#14
Simone Mousinho Freire, Anangela Ravena da Silva Leal, Marcelo Knoff, Delir Corrêa Gomes, Jeannie Nascimento Dos Santos, Elane Guerreiro Giese, Reinaldo José da Silva, Ivete Lopes Mendonça
Chapiniella variabilis (Chapin, 1924), a strongylid nematode, was collected parasitizing the large intestine of the tortoises Chelonoidis carbonarius (Spix, 1824) (Cc) and C. denticulatus (Linnaeus, 1766) (Cd) in the Zoobotanical Park of the municipality of Teresina, state of Piauí, Brazil. The taxonomic identification was based on morphological and morphometric features, using bright-field and scanning electron microscopy. The present study adds new observations on the morphology, mainly relating to the mouth papillae, external and internal leaf-crown elements, excretory pore, deirids and male and female posterior end...
March 16, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28327696/subcrestal-placement-of-dental-implants-with-an-internal-conical-connection-of-0-5%C3%A2-mm-versus-1-5%C3%A2-mm-outcome-of-a-multicentre-randomised-controlled-trial-1-year-after-loading
#15
Federico Gualini, Sergio Salina, Fabio Rigotti, Cristian Mazzarini, Diego Longhin, Mauro Grigoletto, Anna Trullenque-Eriksson, Luca Sbricoli, Marco Esposito
PURPOSE: To evaluate whether there are some clinical benefits by placing single dental implants either 0.5 or 1.5 mm subcrestally in healed bone crests. MATERIALS AND METHODS: Sixty partially edentulous patients requiring two single implant-supported crowns had both sites randomly allocated either to 0.5 mm or 1.5 mm subcrestal implant placement according to a split-mouth design at six centres. Implants were submerged in aesthetic areas or non-submerged in non-aesthetic areas for 3 months...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28327695/do-repeated-changes-of-abutments-have-any-influence-on-the-stability-of-peri-implant-tissues-one-year-post-loading-results-from-a-multicentre-randomised-controlled-trial
#16
Marco Esposito, Eriberto Bressan, Maria Gabriella Grusovin, Ferdinando D'Avenia, Konrad Neumann, Luca Sbricoli, Giuseppe Luongo
PURPOSE: To evaluate the influence of at least three abutment changes in conventionally loaded implants against placement of a definitive abutment in immediately non-occlusal loaded implants on hard and soft tissue changes. MATERIALS AND METHODS: Eighty patients requiring one single crown or one fixed partial prosthesis supported by a maximum of three implants were randomised, after implants were placed with more than 35 Ncm, according to a parallel group design to receive definitive abutments which were loaded immediately (definitive abutment or immediate loading group) or transmucosal abutments...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28327694/safety-and-efficacy-of-a-biomimetic-monolayer-of-permanently-bound-multiphosphonic-acid-molecules-on-dental-implants-3-years-post-loading-results-from-a-pilot-quadruple-blinded-randomised-controlled-trial
#17
Marco Esposito, Ivan Dojcinovic, Sabrina Buchini, Péter Péchy, Björn-Owe Aronsson
PURPOSE: To evaluate the safety and clinical efficacy of a novel surface treatment (SurfLink, Nano Bridging Molecules, Gland, Switzerland) on titanium dental implants. SurfLink consists of a monolayer of permanently bound multiphosphonic acid molecules, which mimics the surface of naturally occurring hydroxyapatite. MATERIALS AND METHODS: Twenty-three patients requiring at least two single dental implants had their sites randomised according to a split-mouth design to receive one titanium grade 4 implant treated with SurfLink and one untreated control implant...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28327692/immediate-immediate-delayed-6%C3%A2-weeks-and-delayed-4%C3%A2-months-post-extractive-single-implants-1-year-post-loading-data-from-a-randomised-controlled-trial
#18
Marco Esposito, Giovanni Zucchelli, Gioacchino Cannizzaro, Luigi Checchi, Carlo Barausse, Anna Trullenque-Eriksson, Pietro Felice
PURPOSE: To compare the clinical outcome of single implants placed immediately after tooth extraction with implants placed 6 weeks after tooth extraction (immediate-delayed placement), and with implants placed after 4-month extraction and socket healing (delayed placement). MATERIALS AND METHODS: Two-hundred and ten (210) patients requiring a single implant-supported crown to replace a tooth to be extracted were randomised to receive immediate post-extractive implants (70 patients), immediate-delayed implants at 6 weeks (70 patients), and delayed implants after 4 months of healing (70 patients) according to a parallel group design...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28327262/clinical-performance-of-pedo-jacket-crowns-in-maxillary-anterior-primary-teeth
#19
Aimee Castro, Sherine B Y Badr, Wafa El-Badrawy, Gajanan Kulkarni
PURPOSES: To assess the clinical performance of Pedo Jacket crowns for restoration of carious primary anterior teeth. METHODS: A total of 129 carious primary incisors and canines of 48 children younger than 71 months of age- were restored with Pedo Jacket crowns and resin-modified glass ionomer cementation. They were assessed for: ease of use; presence of recurrent decay; wear; partial or complete loss of the crown; color stability; gingival health; and overall clinical success over a 12-month follow-up...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28327073/the-influence-of-axial-grooves-on-dislodgment-resistance-of-prosthetic-metal-crowns-in-canine-teeth-of-dogs
#20
Stephanie Goldschmidt, Caitlyn J Collins, Scott Hetzel, Heidi-Lynn Ploeg, Jason W Soukup
The reported failure rate for full veneer crowns of canine teeth of dogs is suboptimal, particularly in teeth with naturally poor retentive features, such as those with low height/diameter (H/D) ratios or high convergence angles (CAs). The objective of the present study was to evaluate the application of axial grooves in an effort to develop a crown preparation design that enhances the retention of full veneer crowns in dogs. Crown dislodgment testing was performed on cast alloy dies of canine teeth with unfavorable retention features (low H/D and high CA) prepared with (n = 14) and without axial grooves (n = 15) to evaluate the force required to dislodge a cemented full veneer crown...
September 2016: Journal of Veterinary Dentistry
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