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https://www.readbyqxmd.com/read/29783955/prediction-of-mortality-in-severe-dengue-cases
#1
Saiful Safuan Md-Sani, Julina Md-Noor, Winn-Hui Han, Syang-Pyang Gan, Nor-Salina Rani, Hui-Loo Tan, Kanimoli Rathakrishnan, Mohd Azizuddin A-Shariffuddin, Marzilawati Abd-Rahman
BACKGROUND: Increasing incidence of dengue cases in Malaysia over the last few years has been paralleled by increased deaths. Mortality prediction models will therefore be useful in clinical management. The aim of this study is to identify factors at diagnosis of severe dengue that predicts mortality and assess predictive models based on these identified factors. METHOD: This is a retrospective cohort study of confirmed severe dengue patients that were admitted in 2014 to Hospital Kuala Lumpur...
May 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29742696/acute-starvation-ketoacidosis-in-pregnancy-with-severe-hypertriglyceridemia-a-case-report
#2
Li Hui, Li Shuying
RATIONALE: Pregnant women are more prone to ketosis due to the relative insulin resistance, accelerated lipolysis and increased free fatty acids. PATIENT CONCERNS: We report a pregnant woman with hyperlipidemia, who experienced severe metabolic acidosis after a short period of starvation. DIAGNOSES: Based on her clinical symptoms, exclusion diagnosis and therapeutic diagnosis, her condition was diagnosed as starvation ketoacidosis. INTERVENTIONS: An emergency caesarean section under general anesthesia was implemented 2 hours after her admission...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739849/a-novel-inhibitor-of-pyruvate-dehydrogenase-kinase-stimulates-myocardial-carbohydrate-oxidation-in-diet-induced-obesity
#3
Cheng-Yang Wu, Santhosh Satapati, Wenjun Gui, Richard M Wynn, Gaurav Sharma, Mingliang Lou, Xiangbing Qi, Shawn C Burgess, Craig Malloy, Chalermchai Khemtong, A Dean Sherry, David Chuang, Matthew E Merritt
The pyruvate dehydrogenase complex (PDC) is a key control point of energy metabolism and is subject to regulation by multiple mechanisms, including post-translational phosphorylation by pyruvate dehydrogenase kinase (PDK). Pharmacological modulation of PDC activity could provide a new treatment for diabetic cardiomyopathy, as dysregulated substrate selection is concomitant with decreased heart function. Dichloroacetate (DCA), a classic PDK inhibitor, has been used to treat diabetic cardiomyopathy, but the lack of specificity and side effects of DCA indicate a more specific inhibitor of PDK is needed...
May 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29728994/differences-in-peritoneal-response-after-exposure-to-low-gdp-bicarbonate-lactate-buffered-dialysis-solution-compared-to-conventional-dialysis-solution-in-a-uremic-mouse-model
#4
M Vila Cuenca, E D Keuning, W Talhout, N J Paauw, F J van Ittersum, P M Ter Wee, R H J Beelen, M G Vervloet, E Ferrantelli
BACKGROUND: Long-term exposure of conventional peritoneal dialysis (PD) fluid is associated with structural membrane alterations and technique failure. Previously, it has been shown that infiltrating IL-17-secreting CD4+T cells and pro-fibrotic M2 macrophages play a critical role in the PD-induced pathogenesis. Although more biocompatible PD solutions are recognized to better preserve the peritoneal membrane integrity, the impact of these fluids on the composition of the peritoneal cell infiltrate is unknown...
May 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29725827/comparison-of-a-new-simplified-acid-base-tool-to-the-original-stewart-figge-approach-a-study-on-cardiac-surgical-patients
#5
Michalis Agrafiotis, Dimitrios Mpliamplias, Maria Papathanassiou, Fotini Ampatzidou, Georgios Drossos
PURPOSE: To suggest a simplified method for strong ion gap ([SIG]) calculation. PATIENTS AND METHODS: To simplify [SIG] calculation, we used the following assumptions: (1) the major determinants of apparent strong ion difference ([SIDa ]) are [Na+ ], [K+ ] and [Cl- ] (2) [Ca2+ ] and [Mg2+ ] do not contribute significantly to [SIDa ] variation and can be replaced by their reference concentrations (3) physiologically relevant pH variation is at the order of 10-2 and therefore we can assume a standard value of 7...
May 3, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29715193/severe-lactic-acidosis-in-an-extremely-low-birth-weight-infant-due-to-thiamine-deficiency
#6
Hulya Ozdemir, Hulya Bilgen, Zeynep Alp Unkar, Ertugrul Kiykim, Asli Memisoglu, Eren Ozek
BACKGROUND: In this case report, we present a preterm newborn with persistent lactic acidosis who received total parenteral nutrition (TPN) that lacked thiamine. CASE PRESENTATION: A 28-week-old, 750 g female infant was born with an Apgar score of 8 at the 5th minute. Umbilical cord blood gas levels, including lactate level, were normal, and she was admitted to our neonatal intensive care unit (NICU). Achieving full enteral feeding was not possible due to gastric residues and abdominal distention, making the patient dependent on TPN during the first 2 weeks of life...
May 1, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29703741/hyperpolarised-magnetic-resonance-for-in-vivo-real-time-metabolic-imaging
#7
REVIEW
Andrew Apps, Justin Lau, Mark Peterzan, Stefan Neubauer, Damian Tyler, Oliver Rider
Although non-invasive perfusion and viability imaging often provide the gateway to coronary revascularisation, current non-invasive imaging methods only report the surrogate markers of inducible hypoperfusion and presence or absence of myocardial scar, rather than actually visualising areas of ischaemia and/or viable myocardium. This may lead to suboptimal revascularisation decisions. Normally respiring (viable) cardiomyocytes convert pyruvate to acetyl-CoA and CO2 /bicarbonate (via pyruvate dehydrogenase), but under ischaemic conditions characteristically shift this conversion to lactate (by lactate dehydrogenase)...
April 27, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29695298/pyruvate-is-a-prospective-alkalizer-to-correct-hypoxic-lactic-acidosis
#8
REVIEW
Ying Wang, Ya Huang, Jing Yang, Fang-Qiang Zhou, Lian Zhao, Hong Zhou
Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful. This paper reviewed data regarding lactic acidosis treatment and recommended that pyruvate might be a potential alkalizer to correct type A lactic acidosis in future clinical practice. Pyruvate is a key energy metabolic substrate and a pyruvate dehydrogenase (PDH) activator with several unique beneficial biological properties, including anti-oxidant and anti-inflammatory effects and the ability to activate the hypoxia-inducible factor-1 (HIF-1α) - erythropoietin (EPO) signal pathway...
April 26, 2018: Military Medical Research
https://www.readbyqxmd.com/read/29680648/effects-of-carbohydrate-type-or-bicarbonate-addition-to-grass-silage-based-diets-on-enteric-methane-emissions-and-milk-fatty-acid-composition-in-dairy-cows
#9
A Bougouin, A Ferlay, M Doreau, C Martin
The aim of the study was to compare the effect of fiber- or starch-rich diets based on grass silage, supplemented or not with bicarbonate, on CH4 emissions and milk fatty acid (FA) profile in dairy cows. The experiment was conducted as a 4 × 4 Latin square design with a 2 × 2 factorial arrangement: carbohydrate type [starch- or fiber-rich diets with dietary starch level of 23.1 and 5.9% on a dry matter basis, respectively], without or with bicarbonate addition [0 and 1% of the dry matter intake, respectively]...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29661284/pyruvate-in-reduced-osmolarity-oral-rehydration-salt-corrected-lactic-acidosis-in-sever-scald-rats
#10
Rui Liu, Shu-Ming Wang, Zong-Yu Li, Wen Yu, Hui-Ping Zhang, Fang-Qiang Zhou
BACKGROUND: A novel pyruvate-based oral rehydration salt (Pyr-ORS) was demonstrated of superiority over bicarbonate- or citrate-based one to preserve organ function and correct lactic acidosis in rehydration of lethal shock in animals. This study further compared these effects between low-osmolar Pyr-ORS and equimolar citrate-based counterpart. METHODS: Eighty rats, using a fatal burn shock model, were randomized into four groups (two subgroups per group: n = 10): the sham group (group SR), Pyr-ORS group (group PR), WHO-ORS III group (group CR), and no rehydration group...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29609531/metformin-associated-lactic-acidosis-a-case-series-of-28-patients-treated-with-sustained-low-efficiency-dialysis-sled-and-long-term-follow-up
#11
Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner, Antonello Pani
BACKGROUND: Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant increase in hospitalizations for MALA to our Center. We report the outcomes of our clinical and therapeutic approach. METHODS: This is a single-center case series. Twenty-eight patients affected with MALA and acute kidney failure admitted between January 2000 and September 2014 were included...
April 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29594982/penile-calciphylaxis-in-a-patient-on-combined-peritoneal-dialysis-and-hemodialysis
#12
Takahiro Kasai, Naoki Washida, Hirokazu Muraoka, Kentarou Fujii, Kiyotaka Uchiyama, Keisuke Shinozuka, Kohkichi Morimoto, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Calciphylaxis presents with painful purpura and intractable skin ulcers on the trunk and particularly the distal extremities, and it mainly occurs in patients on chronic dialysis. A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years. He developed calciphylaxis of the penis, which was diagnosed from the skin biopsy findings and clinical observation. To treat this condition, PD was stopped and HD was performed three times a week...
March 28, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29582226/a-long-term-feed-supplementation-based-on-phosphate-binders-in-feline-chronic-kidney-disease
#13
E Biasibetti, E Martello, M Bigliati, I Biasato, T Cocca, N Bruni, M T Capucchio
Chronic kidney disease (CKD) is a very common disorder in elderly cats. A proper renal diet represents the most efficient therapeutic intervention to improve survival and life quality in feline patients with 3 and 4 International Renal Interest Society (IRIS) stages. Twenty cats were selected in this study. Ten were administered the dietary supplementation for 360 days and the other ten, whose owners did not give consent for any supplemental therapies apart from the renal diet, were selected from a clinical database and used as control group...
March 26, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29524236/acute-hypertensive-stress-imaged-by-cardiac-hyperpolarized-1-13-c-pyruvate-magnetic-resonance
#14
Rasmus Stilling Tougaard, Esben Søvsø Szocska Hansen, Christoffer Laustsen, Jakob Lindhardt, Marie Schroeder, Hans Erik Bøtker, Won Yong Kim, Henrik Wiggers, Hans Stødkilde-Jørgensen
PURPOSE: Deranged metabolism is now recognized as a key causal factor in a variety of heart diseases, and is being studied extensively. However, invasive methods may alter metabolism, and conventional imaging techniques measure tracer uptake but not downstream metabolism. These challenges may be overcome by hyperpolarized MR, a noninvasive technique currently crossing the threshold into human trials. The aim of this study was to image metabolic changes in the heart in response to endogastric glucose bolus and to acute hypertension...
March 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29515645/evaluation-of-capillary-leakage-after-vasopressin-resuscitation-in-a-hemorrhagic-shock-model
#15
Roberto Bini, Osvaldo Chiara, Stefania Cimbanassi, Giorgio Olivero, Antonella Trombetta, Paolo Cotogni
Background: Hemorrhagic shock (HS) is a major threat to patients with trauma and spontaneous bleeding. The aim of the study was to investigate early effects of vasopressin on metabolic and hemodynamic parameters and endothelium permeability by measuring capillary leakage compared to those of other resuscitation strategies in a HS model. Methods: Forty-five Sprague-Dawley rats were randomized into five groups: S group ( n  = 5), sham-operated rats without shock or resuscitation; HS group ( n  = 10), HS and no resuscitation; RL group ( n  = 10), HS and resuscitation with Ringer's lactate (RL); RLB group ( n  = 10), HS and resuscitation with two-third shed blood plus RL; and vasopressin group ( n  = 10), HS and resuscitation with RL, followed by continuous infusion of 0...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29515400/lactic-acidosis-in-prostate-cancer-consider-the-warburg-effect
#16
Johannes C van der Mijn, Mathijs J Kuiper, Carl E H Siegert, Annabeth E Wassenaar, Carel J M van Noesel, Aernout C Ogilvie
Lactic acidosis is a commonly observed clinical condition that is associated with a poor prognosis, especially in malignancies. We describe a case of an 81-year-old patient who presented with symptoms of tachypnea and general discomfort. Arterial blood gas analysis showed a high anion gap acidosis with a lactate level of 9.5 mmol/L with respiratory compensation. CT scanning showed no signs of pulmonary embolism or other causes of impaired tissue oxygenation. Despite treatment with sodium bicarbonate, the patient developed an adrenalin-resistant cardiac arrest, most likely caused by the acidosis...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29509139/determination-of-reference-intervals-and-comparison-of-venous-blood-gas-parameters-using-a-standard-and-nonstandard-collection-method-in-51-dogs
#17
K Bachmann, A Kutter, R S Jud Schefer, N Sigrist
The aim of this study was to determine reference intervals (RI) for venous blood parameters determined with the RAPIDPoint 500 (RP500) blood gas analyzer using blood gas syringes (BGS) and to determine whether immediate analysis of venous blood collected into lithium heparin (LH) tubes can replace anaerobic blood sampling into BGS. The null hypothesis was that canine venous blood samples collected in BGS and in LH tubes are comparable. Jugular blood was collected from 51 healthy dogs into a BGS and a LH tube...
March 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29476629/ph-dependent-speciation-and-hydrogen-h-2-control-u-vi-respiration-by-desulfovibrio-vulgaris
#18
Shilpi Kushwaha, Andrew K Marcus, Bruce E Rittmann
In situ bioreduction of soluble hexavalent uranium U(VI) to insoluble U(IV) (as UO2 ) has been proposed as a means of preventing U migration in the groundwater. This work focuses on the bioreduction of U(VI) and precipitation of U(IV). It uses anaerobic batch reactors with Desulfovibrio vulgaris, a well-known sulfate, iron, and U(VI) reducer, growing on lactate as the electron donor, in the absence of sulfate, and with a 30-mM bicarbonate buffering. In the absence of sulfate, D. vulgaris reduced  >90% of the total soluble U(VI) (1 mM) to form U(IV) solids that were characterized by X-ray diffraction and confirmed to be nano-crystalline uraninite with crystallite size 2...
June 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29463034/chronic-ketogenic-low-carbohydrate-high-fat-diet-has-minimal-effects-on-acid-base-status-in-elite-athletes
#19
Amelia J Carr, Avish P Sharma, Megan L Ross, Marijke Welvaert, Gary J Slater, Louise M Burke
Although short (up to 3 days) exposure to major shifts in macronutrient intake appears to alter acid-base status, the effects of sustained (>1 week) interventions in elite athletes has not been determined. Using a non-randomized, parallel design, we examined the effect of adaptations to 21 days of a ketogenic low carbohydrate high fat (LCHF) or periodized carbohydrate (PCHO) diet on pre- and post-exercise blood pH, and concentrations of bicarbonate (HCO₃- ) and lactate (La- ) in comparison to a high carbohydrate (HCHO) control...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29461290/volume-resuscitation-in-patients-with-high-voltage-electrical-injuries
#20
Derek M Culnan, Kelley Farner, Genevieve H Bitz, Karel D Capek, Yiji Tu, Carlos Jimenez, William C Lineaweaver
Volume resuscitation of patients with high-voltage electrical injuries (>1000 V) is a more complex challenge than standard burn resuscitation. High voltages penetrate deep tissues. These deep injuries are not accounted for in resuscitation formulae dependent on percentage of cutaneous burn. Myonecrosis occurring from direct electrical injury and secondary compartment syndromes can result in rhabdomyolysis, compromising renal function and urine output. Urine output is the primary end point, with a goal of 1 mL/kg/h for adult patients with high-voltage electrical injuries...
March 2018: Annals of Plastic Surgery
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