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albumin creatinine ratio

Tatsuo Hosoya, Tomohiko Ishikawa, Yoshimi Ogawa, Ryusuke Sakamoto, Tetsuo Ohashi
BACKGROUND AND OBJECTIVES: Topiroxostat-a novel selective xanthine oxidoreductase inhibitor-has been reported to reduce serum urate levels. The purpose of this study was to assess the efficacy and safety of long-term topiroxostat administration in Japanese hyperuricemic patients with or without gout. METHODS: This multicenter, open-label study evaluated the efficacy and safety of long-term twice-daily oral topiroxostat administration in patients with or  without gout...
September 15, 2018: Clinical Drug Investigation
Ayelet Grupper, Doron Schwartz, Shlomo Berliner, Moshe Shashar, Avishay Grupper, Roni Baruch, Idit F Schwartz, Talia Weinstein, Orit Kliuk Ben-Bassat, Ori Rogowski, David Zeltser, Itzhak Shapira, Shani Shenhar-Tsarfaty
Albuminuria is a prognostic factor for mortality and cardiovascular events, even at low levels. Changes in albumin excretion are associated with end-stage renal disease and hypertension (HTN) in cohorts including high-risk participants. We aimed to investigate the evolvement of albumin excretion in healthy individuals with normal kidney function and normoalbuminuria, and possible associations with HTN and metabolic outcomes. The study cohort consisted of 1967 healthy adults with normal kidney function (estimated glomerular filtration rate ≥ 90 mL/min/1...
August 23, 2018: Journal of the American Society of Hypertension: JASH
A L Diehl, J K Bernard, S Tao, T N Smith, D J Kirk, D J McLean, J D Chapman
Eighty-two multiparous Holstein cows were enrolled 28 d before expected calving and assigned to 1 of 4 dietary treatments in a randomized block design experiment with a 2 × 2 factorial arrangement of treatments to determine the effect of feeding a neutral or acidogenic diet varying in Ca concentration on prepartum and postpartum intake, blood mineral and metabolite concentrations, and postpartum milk production. Prepartum diets were formulated to provide a dietary cation-anion difference (DCAD) of -21 (NEG) or -2 (NEU) mEq/100 g of dry matter (NEU) with either 1...
September 12, 2018: Journal of Dairy Science
Karla S Costa de Souza, Iago de Souza Gomes, Yonara M da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Thamara Rodrigues de Melo, Marcos Gonzaga Dos Santos, Raul Hernandes Bortolin, José J Maciel Neto, Ricardo F Arrais, Maria das G Almeida, Marcela Abbott Galvão Ururahy, Adriana A de Rezende
AIM: To evaluate glycaemic control and its influence on albuminuria and bone mineral density (BMD) in children and adolescents with type 1 diabetes (T1D). METHODS: We collectively assessed 84 T1D children/adolescents (T1D group), aged between 6 and 17 years, and then divided them into two groups according to their glycaemic profile (T1D with good glycaemic control (T1DG group) and T1D with poor glycaemic control (T1DP group)). Serum glucose, glycated haemoglobin, serum urea, serum creatinine, urinary albumin-to-creatinine ratio (ACR), estimated glomerular filtration rate and BMD levels were assessed...
September 15, 2018: Journal of Paediatrics and Child Health
Sung Soo Ahn, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
We investigated whether albumin to globulin ratio (AGR) at diagnosis may be associated with all-cause mortality in immunosuppressive drug-naïve patients with microscopic polyangiitis (MPA). We retrospectively reviewed the medical records of 88 MPA patients, who were first classified and in whom medications was first initiated in our tertiary Hospital. We collected clinical and laboratory data as well as the rate of all-cause mortality. AGR at diagnosis was calculated as a ratio of serum albumin over globulin fraction (protein-albumin)...
September 15, 2018: Clinical Rheumatology
Yanlin Ren, Dingkun Wang, Fuer Lu, Xin Zou, Lijun Xu, Kaifu Wang, Wenya Huang, Hao Su, Chu Zhang, Yang Gao, Hui Dong
BACKGROUND: Obese subjects have been considered to be in a state of chronic, low-grade systemic inflammation. Excess fat accumulation and persistent inflammation may promote renal dysfunction, to cause chronic kidney disease (CKD) and even end-stage kidney failure. Coptidis Rhizoma is a classical traditional Chinese herb well known for its hypoglycemic and hypolipidemic properties. The mechanism is partially associated with its anti-inflammatory effect. However, this effect is rarely investigated in obesity and obesity-related glomerulopathy (ORG)...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Miguel Bigotte Vieira, Rita Magriço, Catarina Viegas Dias, Lia Leitão, João Sérgio Neves
Background: An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the association between caffeine consumption and mortality in patients with chronic kidney disease (CKD) remains uncertain. Methods: We analysed 4863 non-institutionalized USA adults with CKD [defined by an estimated glomerular filtration rate (eGFR) of 15-60 mL/min/1.73 m2 and/or a urinary albumin:creatinine ratio >30 mg/g] in a nationwide study using the National Health and Nutrition Examination Survey (NHANES) 1999-2010...
September 12, 2018: Nephrology, Dialysis, Transplantation
Hanan Amadid, Nanna B Johansen, Anne-Louise Bjerregaard, Søren Brage, Kristine Færch, Torsten Lauritzen, Daniel R Witte, Annelli Sandbæk, Marit E Jørgensen, Dorte Vistisen
BACKGROUND: Ambiguity exists in relation to the role of physical activity (PA) for cardiovascular disease (CVD) risk reduction. We examined the interplay between PA dimensions and more conventional CVD risk factors to assess which PA dimensions were associated with the first CVD event and whether subgroup differences exist. METHODS: A total of 1449 individuals [median age 65.8 (IQR: 61.2, 70.7) years] with low to high risk of type 2 diabetes and free from CVD from the Danish ADDITION-PRO study were included for survival analysis...
September 12, 2018: Cardiovascular Diabetology
Michele F Eisenga, Ilja M Nolte, Peter van der Meer, Stephan J L Bakker, Carlo A J M Gaillard
BACKGROUND: Iron deficiency is highly prevalent in chronic kidney disease (CKD) patients. In clinical practice, iron deficiency is defined based on a combination of two commonly used markers, ferritin and transferrin saturation (TSAT). However, no consensus has been reached which cutoffs of these parameters should be applied to define iron deficiency. Hence, we aimed to assess prospectively which cutoffs of ferritin and TSAT performed optimally for outcomes in CKD patients. METHODS: We meticulously analyzed 975 CKD community dwelling patients of the Prevention of Renal and Vascular Endstage Disease prospective study based on an estimated glomerular filtration rate < 60 ml/min/1...
September 12, 2018: BMC Nephrology
Katja Braun, Felix Atmanspacher, Rolf Schreckenberg, Ivica Grgic, Klaus-Dieter Schlüter
An active lifestyle is generally recommended for hypertensive patients to prevent subsequent end-organ damage. However, experimental data on long-term effects of exercise on hypertension are insufficient and underlying mechanisms are not well understood. This study was aimed to investigate the effect of exercise on renal expression of parathyroid hormone-related protein (PTHrP) and parathyroid hormone receptor type 1 (PTHR1) in spontaneously hypertensive rats (SHR). Twenty-four rats started free running wheel exercise at the age of 1...
September 2018: Physiological Reports
Ruth F Dubin, Suzanne Judd, Rebecca Scherzer, Michael Shlipak, David G Warnock, Mary Cushman, Mark Sarnak, Chirag Parikh, Michael Bennett, Neil Powe, Carmen A Peralta
Introduction: Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury. In persons with reduced estimated glomerular filtration rate (eGFR) and albuminuria who are at high risk for end-stage renal disease (ESRD) and death, the associations of these urinary markers with incident ESRD or death is an area of active investigation. Methods: Among 1472 black and white participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study with eGFR ≤60 ml/min per 1...
September 2018: KI Reports
Fang Wang, Kevin He, Jinwei Wang, Ming-Hui Zhao, Yi Li, Luxia Zhang, Rajiv Saran, Jennifer L Bragg-Gresham
Introduction: Chronic kidney disease (CKD) is an important noncommunicable disease globally. Overall prevalence of CKD and distribution of its stages differ between countries. We postulate that these differences may not only be due to variation in prevalence of risk factors but also their differential impact in different populations or settings. Methods: We used nationally representative data on the adult populations from both the United States (US; National Health and Nutrition Examination Survey [NHANES], 2009 to 2010, N = 5557) and China (China National Survey of CKD, 2009 to 2010, N = 46,949)...
September 2018: KI Reports
Vinay Kumar, Suraj Hebbar, Ananthram Bhat, Sachin Panwar, Madhumati Vaishnav, Kavitha Muniraj, Vasanthi Nath, Reshma Banaki Vijay, Sapna Manjunath, Babithadevi Thyagaraj, Chandraprabha Siddalingappa, Muralidharakrishna Chikkamoga Siddaiah, Indranil Dasgupta, Urmila Anandh, Thummala Kamala, S S Srikanta, P R Krishnaswamy, Navakanta Bhat
Introduction: Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world. Methods: We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD...
September 2018: KI Reports
Weiwei Han, Dongliang Wang, Yunqin Wu, Zhenyi Fan, Xu Guo, Qiongfeng Guan
PURPOSE: To investigate the relationship between cerebrovascular risk factors, including carotid plaques, and vestibular neuritis (VN). MATERIALS AND METHODS: According to the inclusion and exclusion criteria, this retrospective study included 90 VN patients and 74 age- and sex-matched healthy controls from January 2016 to December 2017. All subjects' records of cerebrovascular risk factors, such as age, sex, height, weight, history of hypertension and diabetes mellitus, living habits, serum levels of glucose, lipids, glycosylated haemoglobin (HbA1c), creatinine (CR), albumin (ALB), haemoglobin (HGB); and results of carotid colour Doppler ultrasound, were obtained and compared...
August 29, 2018: American Journal of Otolaryngology
A Mantovani, R Rigolon, T Turino, I Pichiri, A Falceri, A Rossi, P L Temporelli, S Bonapace, G Lippi, G Zoppini, E Bonora, C D Byrne, G Targher
AIM: We aimed to assess the association between decreasing estimated glomerular filtration rate (eGFR) or abnormal albuminuria and the risk of certain cardiac conduction defects in patients with type 2 diabetes mellitus (T2DM). METHODS: We examined a hospital-based sample of 923 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Standard electrocardiograms (ECGs) were performed in all patients. eGFR was estimated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, whilst albuminuria was measured by an immuno-nephelometric method on morning spot urine samples...
September 5, 2018: Diabetes & Metabolism
Hui Ma, Huandong Lin, Yu Hu, Xiaoming Li, Wanyuan He, Xuejuan Jin, Jian Gao, Naiqing Zhao, Boshen Pan, Xin Gao
Associations between ferritin and insulin sensitivity have been described in recent studies. The possible association showed conflicting results by sex and menopausal status. We aimed to investigate the cross-sectional association of ferritin levels with insulin resistance and β-cell function. A total of 2518 participants (1033 men, 235 pre-menopausal women and 1250 post-menopausal women) were enrolled from the Changfeng Study. A standard interview was conducted, as well as anthropometric measurements and laboratory analyses, for each participant...
September 7, 2018: British Journal of Nutrition
Brian R Ott, Richard N Jones, Lori A Daiello, Suzanne M de la Monte, Edward G Stopa, Conrad E Johanson, Charles Denby, Paula Grammas
Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier (BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell activation and cytokine mediated inflammation. Methods: Cerebrospinal fluid (CSF) and peripheral blood were concurrently collected from cognitively healthy controls ( N = 21) and patients with mild cognitive impairment (MCI) ( N = 8) or AD ( N = 11). The paired serum and CSF samples were assayed for a panel of cytokines, chemokines, and related trophic factors using multiplex ELISAs...
2018: Frontiers in Aging Neuroscience
Krishna C Keri, Naga S Samji, Samuel Blumenthal
Diabetic nephropathy (DN is a dreaded consequence of diabetes mellitus, accounting for about 40% of end-stage renal disease (ESRD). It is responsible for significant morbidity and mortality, both directly by causing ESRD and indirectly by increasing cardiovascular risk. Extensive research in this field has thrown light on multiple pathways that can be pharmacologically targeted, to control or reverse the process of DN. Glomerulocentric approach of DN still continues to produce favourable results as evidenced by the recent data on SGLT-2 (sodium glucose co-transporter type 2) inhibitors...
2018: Journal of Community Hospital Internal Medicine Perspectives
K Xu, X Y Mao, Y Yao, H Cheng, X J Zhang
Objective: To explore the clinical and genetic characteristics of infantile nephrotic syndrome caused by COQ2 variants. Methods: The clinical and genetic data of a patient with nephrotic syndrome caused by COQ2 variants diagnosed at pediatric department of Peking University First Hospital from February 2018 to March 2018 were retrospectively analyzed. Related literature retrieved from PubMed, CNKI and Wanfang databases were searched to date (up to July 2018) with "COQ2 gene" or "primary coenzyme Q10 deficiency" and "nephrotic syndrome" or "nephropathy" as key words...
September 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Riyaz U Saif, Hilal Ahmad Dar, Sozia Mohammad Sofi, Mushtaq Saif Andrabi, Gul Javid, Showkat Ali Zargar
BACKGROUND: Hepatorenal syndrome (HRS) occurs in decompensated liver disease and carries high mortality. Vasoconstrictors are the drug of choice. Terlipressin is widely used and is expensive. In this study, we compared noradrenaline and terlipressin in the management of type 1 HRS. METHODS: Sixty consecutive patients with type 1 HRS were managed with noradrenaline (Group A, n = 30) or terlipressin (Group B, n = 30) with albumin in a randomized controlled trial at a tertiary center...
September 3, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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