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albumin creatinine ratio

Fengying Wang, Xiaozhong Li, Xueming Zhu, Qing Chen, Lu Jiang, Ziqiang Zhu
Background: This study aimed to investigate the clinical significance of complement 3 (C3) deposition in renal tubules of children with primary nephrotic syndrome (PNS). Methods: The clinical and pathological characteristics of PNS were retrospectively reviewed in 99 PNS pediatric patients, who were divided into the C3 deposition and the non-C3 deposition groups. Results: A total of 39 patients (39.39%) had renal tubule C3 deposition. In the C3 deposition group, the ratios of urine N-acetylglucosaminidase/creatinine (UNAG/Cr), urine β 2 microglobulin/creatinine (U β 2MG/Cr), and urine transferrin/creatinine (UTRF/Cr) were significantly higher than those of the non-C3 deposition group...
2018: BioMed Research International
Richard Haynes, Parminder K Judge, Natalie Staplin, William G Herrington, Benjamin C Storey, Angelyn Bethel, Louise Bowman, Nigel Brunskill, Paul Cockwell, Michael Hill, Philip A Kalra, John J V McMurray, Maarten Taal, David C Wheeler, Martin J Landray, Colin Baigent
Background -Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate-to-severe chronic kidney disease are unknown. Methods -UK HARP-III was a randomised double-blind trial which included 414 participants with an estimated glomerular filtration rate (GFR) 20-60 mL/min/1.73m2 who were randomly assigned to sacubitril/valsartan 97/103 mg twice daily versus irbesartan 300 mg once daily...
July 12, 2018: Circulation
Ying Fan, Yang Fei, Li Zheng, Jiemin Wang, Wenzhen Xiao, Jiejun Wen, Yanping Xu, Yiyun Wang, Li He, Jian Guan, Jia Wei, John Cijiang He, Niansong Wang
BACKGROUND/AIMS: Glomerular endothelial cell injury plays a crucial role in the development of diabetic nephropathy (DN). CD146, an endothelial marker, was shown to increase in chronic kidney disease (CKD), but its role in DN remains unknown. We aim to assess whether CD146 could be used to evaluate disease severity and predict renal outcomes in DN at early stages. METHODS: 159 non-dialysis type 2-DN patients from 2008 to 2015 were enrolled to measure the plasma concentration of soluble CD146 (sCD146)...
July 12, 2018: Cellular Physiology and Biochemistry
Dong-Hui Ao, Fei-Fei Zhai, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Ding-Ding Zhang, Ming-Li Li, Xiao-Hong Fan, Zheng-Yu Jin, Li-Ying Cui, Shu-Yang Zhang, Yi-Cheng Zhu
Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence has been lacking. Methods: A total of 928 participants from a population-based cohort study were included. Kidney injury measurements included urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR)...
2018: Frontiers in Neurology
Andrew Bostom, Andreas Pasch, Tracy Madsen, Mary B Roberts, Nora Franceschini, Dominik Steubl, Pranav S Garimella, Joachim H Ix, Katherine R Tuttle, Anastasia Ivanova, Theresa Shireman, Reginald Gohh, Basma Merhi, Petr Jarolim, John W Kusek, Marc A Pfeffer, Simin Liu, Charles B Eaton
BACKGROUND: "T50," shortened transformation time from primary to secondary calciprotein particles may reflect deranged mineral metabolism predisposing to vascular calcification and cardiovascular disease (CVD). The glycoprotein fetuin-A is a major T50 determinant. METHODS: The Folic Acid For Vascular Outcome Prevention In Transplantation (FAVORIT) cohort is a completed, large, multiethnic controlled clinical trial cohort of chronic, stable kidney transplant recipients (KTRs)...
July 11, 2018: American Journal of Nephrology
Xiaoqing Ni, Yunjuan Gu, Haoyong Yu, Shenqi Wang, Ying Chen, Xinlei Wang, Xinlu Yuan, Weiping Jia
Serum fatty acid-binding protein 4 (FABP4) has been linked to renal dysfunction. This study evaluated the association between serum FABP4 and the radioisotope glomerular filtration rate (rGFR) in type 2 diabetic patients (T2DM) with early diabetic nephropathy. Twenty healthy controls and 172 patients with T2DM were enrolled. Serum FABP4 and renal impairment biomarkers including urinary albumin-to-creatinine ratio (UACR), serum retinal-binding protein 4 (RBP4), urinary cystatin C-to-creatinine ratio (CysC/Cr), and neutrophil gelatinase-associated lipocalin-to-creatinine ratio (NGAL/Cr) were measured...
2018: BioMed Research International
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Toralf Melsom, Marit Dahl Solbu, Jørgen Schei, Vidar Tor Nyborg Stefansson, Jon Viljar Norvik, Trond Geir Jenssen, Tom Wilsgaard, Bjørn Odvar Eriksen
Introduction: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, cardiovascular, or chronic kidney disease. Methods: In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1567 middle-aged nondiabetic individuals with an ACR <3...
July 2018: KI Reports
Margaret Smith, William G Herrington, Misghina Weldegiorgis, Fd Richard Hobbs, Clare Bankhead, Mark Woodward
Introduction: Changes in urinary albumin-to-creatinine ratio (UACR) may affect the risk of advanced chronic kidney disease (CKD). How much the association changes after taking account for natural variation in UACR and the length of time taken to observe changes in UACR is unknown. Methods: English Clinical Practice Research Datalink records (2000-2015) with linkage to secondary care and death certification were used to identify prospective cohorts with at least 2 measures of UACR within 1, 2, and 3 years...
July 2018: KI Reports
A Sattarinezhad, J Roozbeh, B Shirazi Yeganeh, G R Omrani, M Shams
AIM: Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500mg/day) or placebo for 90 days. Losartan (12.5mg/day) was also administered to all participants...
June 8, 2018: Diabetes & Metabolism
Liang Feng, Hithanadura Asita de Silva, Imtiaz Jehan, Aliya Naheed, Anuradhani Kasturiratne, Gulshan Himani, Mohammad Abul Hasnat, Tazeen H Jafar
Background: We aimed to determine the prevalence of chronic kidney disease (CKD) and its cross-country variation among hypertensive individuals in rural Bangladesh, Pakistan and Sri Lanka. We also explored the factors associated with CKD in these populations. Method: We studied baseline data from the Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan and Sri Lanka (COBRA-BPS) trial, an ongoing cluster randomized controlled trial on 2643 hypertensive adults ≥40 years of age from 30 randomly selected rural clusters, 10 in each of the three countries...
July 5, 2018: Nephrology, Dialysis, Transplantation
Andreas Heinzel, Michael Kammer, Gert Mayer, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B Mark, Wenjun Ju, Matthias Kretzler, Peter Gilmour, Jonathan M Wilson, Kevin L Duffin, Moustafa Abdalla, Mark I McCarthy, Georg Heinze, Hiddo L Heerspink, Andrzej Wiecek, Maria F Gomez, Rainer Oberbauer
OBJECTIVE: The decline of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes is variable, and early interventions would likely be cost-effective. We elucidated the contribution of 17 plasma biomarkers to the prediction of eGFR loss on top of clinical risk factors. RESEARCH DESIGN AND METHODS: We studied participants in PROVALID (PROspective cohort study in patients with type 2 diabetes mellitus for VALIDation of biomarkers), a prospective multinational cohort study of patients with type 2 diabetes and a follow-up of more than 24 months ( n = 2,560; baseline median eGFR, 84 mL/min/1...
July 6, 2018: Diabetes Care
Minyoung Lee, Namki Hong, Yong-Ho Lee, Eun Seok Kang, Bong Soo Cha, Byung-Wan Lee
AIMS: Recent evidence has shown that renal tubulointerstitial injuries play an important role in diabetic nephropathy. In this study, we evaluated the association between urinary N-acetyl-β-d-glucosaminidase (uNAG), an early renal tubular damage marker, and carotid artery atherosclerosis in patients with type 1 diabetes (T1D). METHODS: This was a cross-sectional study of 88 patients with T1D. Demographic and laboratory data; urinary indices, including urinary NAG-to-creatinine ratio (uNCR), and albumin-to-creatinine ratio (uACR); and carotid ultrasonography were investigated...
June 1, 2018: Journal of Diabetes and its Complications
Xin-Bin Wang, En-Lai Dai, Guo-Zhong Xue, Rui-Ling Ma
BACKGROUND: The present study aims to comprehensively determine the efficacy of different therapy regimens based on Tripterygium wilfordii Hook F (TwHF) for patients with primary nephrotic syndrome (PNS) using network meta-analysis method. METHODS: Seven electronic databases were searched to identify randomized controlled trials (RCTs) that compared the differences between different therapy regimens based on TwHF for patients with PNS. The risk of bias in included RCTs was evaluated according to the Cochrane Handbook version 5...
July 2018: Medicine (Baltimore)
Francois M Kajingulu, Francois B Lepira, Fiston I Mbutiwi, Jean-Robert Makulo, Ernest K Sumaili, Justine B Bukabau, Vieux M Mokoli, Augustin L Longo, Nazaire M Nseka
Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia. The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according to albuminuria status. This was a post hoc analysis of data from 181 T2DM patients seen at a tertiary health-care hospital and enrolled in a cross-sectional study of albuminuria status. Abnormal albuminuria was defined as microalbuminuria [albumin to creatinine ratio (ACR) 30-299...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
Jennifer A Hirst, Maria Dla Vazquez Montes, Clare J Taylor, José M Ordóñez-Mena, Emma Ogburn, Vanshika Sharma, Brian Shine, Tim James, Fd Richard Hobbs
BACKGROUND: Chronic kidney disease (CKD) is diagnosed using the estimated glomerular filtration rate (eGFR) and the urinary albumin:creatinine ratio (ACR). The eGFR is calculated from serum creatinine levels using the Modification of Diet in Renal Disease (MDRD) or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. AIM: To compare the performance of one versus two eGFR/ACR measurements, and the impact of equation choice, on CKD diagnosis and classification...
July 2, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Yu-Jih Su, I-Chun Lin, Lin Wang, Cheng-Hsien Lu, Yi-Ling Huang, Ho-Chang Kuo
The symptomatology of lupus nephritis (LN) consists of foamy urine and lower leg edema, as well as such systemic manifestations as oral ulcers, arthralgia/arthritis, and lymphadenopathy. However, these symptoms may appear mild and non-specific. If these symptoms are unrecognized, thus delaying treatment, approximately 10% of LN patients will develop permanent kidney damage and end-stage kidney disease. Therefore, the purpose of this study is to identify a surrogate biomarker for the early detection of LN. In this study, we first adopted next generation sequencing (NGS) in order to screen differential expression levels of microRNA between SLE patients with and without LN...
June 15, 2018: Oncotarget
Stephanie Lankhorst, Hans J Baelde, Jose A M C Verstijnen, Albert J Ten Tije, Marc H M Thelen, A H Jan Danser, Anton H van den Meiracker, Mariëtte H W Kappers
Angiogenesis inhibition with bevacizumab, a monoclonal antibody against vascular endothelial growth factor A (VEGF-A), is an anticancer treatment associated with hypertension and renal glomerular toxicity referred to as a preeclampsia-like syndrome. In preeclampsia, podocyturia predates proteinuria and clinical features of preeclampsia, and is regarded as a biomarker of ongoing glomerular injury. Using a quantitative polymerase chain reaction of the podocyte-specific molecules nephrin, podocin, and VEGF-A in the urine, we examined whether podocyturia is present in bevacizumab-treated cancer patients, and whether it relates to proteinuria and the cumulative dose of bevacizumab...
June 18, 2018: Journal of the American Society of Hypertension: JASH
Salwa S Hosny, Meram M Bekhet, Hayam A Hebah, Nagwa R Mohamed
BACKGROUND: Diabetes mellitus is the leading cause of end stage renal disease worldwide. Early identification of diabetic nephropathy even before appearance of microalbuminuria is a challenge for early prevention of occurrence and progression of this complication. Neutrophil gelatinase-associated lipocalin is a small protein that belongs to the lipocalin protein. Urinary neutrophil gelatinase-associated lipocalin is a promising early marker in different renal problems. AIM OF THE WORK: To measure urinary neutrophil gelatinase-associated lipocalin in type 2 diabetic patients and to assess its role as an early marker for diagnosis of diabetic nephropathy and diabetic retinopathy...
June 21, 2018: Diabetes & Metabolic Syndrome
Sanaz Sedaghat, Jie Ding, Gudny Eiriksdottir, Mark A van Buchem, Sigurdur Sigurdsson, M Arfan Ikram, Osorio Meirelles, Vilmundur Gudnason, Andrew S Levey, Lenore J Launer
Decreased glomerular filtration rate (GFR) and albuminuria may be accompanied by brain pathology. Here we investigated whether changes in these kidney measures are linked to development of new MRI-detected infarcts and microbleeds, and progression of white matter hyperintensity volume. The study included 2671 participants from the population-based AGES-Reykjavik Study (mean age 75, 58.7% women). GFR was estimated from serum creatinine, and albuminuria was assessed by urinary albumin-to-creatinine ratio. Brain MRI was acquired at baseline (2002-2006) and 5 years later (2007-2011)...
June 27, 2018: Kidney International
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