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https://www.readbyqxmd.com/read/27919768/proximal-femoral-fractures-in-centenarians-a-retrospective-analysis-of-39-patients
#1
A Morice, N Reina, G Gracia, P Bonnevialle, J-M Laffosse, K Wytrykowski, E Cavaignac, N Bonnevialle
BACKGROUND: A corollary of the current population ageing in France is an increase in proximal femoral fractures (PFFs), particularly among centenarians. The outcomes of PFF in centenarians in France are unknown. We therefore conducted a retrospective study of centenarians with PFFs both to assess: 1) assess clinical outcomes according to geriatric and trauma scores, 2) and to determine whether routine surgery is warranted. HYPOTHESIS: Morbidity and mortality in a single-centre cohort of centenarians with surgically treated PFFs are consistent with previous reports...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27917918/distinct-epigenomes-in-cd4-t-cells-of-newborns-middle-ages-and-centenarians
#2
Ming Zhao, Jian Qin, Hanqi Yin, Yixin Tan, Wei Liao, Qian Liu, Shuangyan Luo, Min He, Gongping Liang, Yajing Shi, Qing Zhang, Wenjun Cai, Guangliang Yin, Yin Zhou, Jing Wang, Mengying Li, Yi Huang, Aiyun Liu, Haijing Wu, Zhiyong Zhang, Qianjin Lu
Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are unclear. We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4(+)T cells from newborn (NB), middle-aged (MA) and long-lived (LL) individuals to elucidate the molecular changes and their interactions. A total 659 genes showed significantly expression changes across NB, MA and LL individuals, in which we identified four age-related co-expression modules with three hub networks of co-expressed genes and non-coding RNAs...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905975/health-profile-of-centenarians-in-portugal-a-census-based-approach
#3
Oscar Ribeiro, Laetitia Teixeira, Lia Araújo, Constança Paúl
BACKGROUND: The number of centenarians is rapidly increasing in Europe. In Portugal, it has almost tripled over the last 10 years and constitutes one of the fastest-growing segments of the population. This paper aims to describe the health and sociodemographic characteristics of Portuguese centenarians as given in the 2011 census and to identify sex differences. METHODS: All persons living in Portugal mainland and Madeira and Azores islands aged 100 years old at the time of the 2011 census (N = 1,526) were considered...
April 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27890377/corrigendum-to-cetp-polymorphisms-confer-genetic-contribution-to-centenarians-of-hainan-south-of-china-asian-pac-j-trop-med-9-9-2016-872-876
#4
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu
No abstract text is available yet for this article.
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27861536/muscle-related-polymorphisms-mstn-rs1805086-and-actn3-rs1815739-are-not-associated-with-exceptional-longevity-in-japanese-centenarians
#5
Noriyuki Fuku, Rafael Alis, Thomas Yvert, Hirofumi Zempo, Hisashi Naito, Yukiko Abe, Yasumichi Arai, Haruka Murakami, Motohiko Miyachi, Helios Pareja-Galeano, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical...
2016: PloS One
https://www.readbyqxmd.com/read/27845177/demographic-phenotypic-and-genetic-characteristics-of-centenarians-in-okinawa-and-japan-part-1-centenarians-in-okinawa
#6
REVIEW
Bradley J Willcox, Donald Craig Willcox, Makoto Suzuki
A study of elderly Okinawans has been carried out by the Okinawa Centenarian Study (OCS) research group for over four decades. The OCS began in 1975 as a population-based study of centenarians (99-year-olds and older) and other selected elderly persons residing in the main island of the Japanese prefecture of Okinawa. As of 2015, over 1000 centenarians have been examined. By several measures of health and longevity the Okinawans can claim to be the world's healthiest and longest-lived people. In this paper we explore the demographic, phenotypic, and genetic characteristics of this fascinating population...
November 12, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27794564/human-exceptional-longevity-transcriptome-from-centenarians-is-distinct-from-septuagenarians-and-reveals-a-role-of-bcl-xl-in-successful-aging
#7
Consuelo Borras, Kheira M Abdelaziz, Juan Gambini, Eva Serna, Marta Inglés, Monica de la Fuente, Idoia Garcia, Ander Matheu, Paula Sanchís, Angel Belenguer, Alessandra Errigo, Juan-Antonio Avellana, Ana Barettino, Carla Lloret-Fernández, Nuria Flames, Gianni Pes, Leocadio Rodriguez-Mañas, Jose Viña
Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians when compared with septuagenarians and young people. Sub-network analysis led us to identify Bcl - xL as an important gene up-regulated in centenarians. It is involved in the control of apoptosis, cellular damage protection and also in modulation of immune response, all associated to healthy aging...
October 28, 2016: Aging
https://www.readbyqxmd.com/read/27754234/os-34-01-association-of-combination-of-hypertension-and-diabetes-with-cognitive-function-among-the-70-years-old-japanese-general-population-from-longitudinal-observation-in-the-sonic-study
#8
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748531/longitudinal-study-of-factors-affecting-taste-sense-decline-in-old-old-individuals
#9
Taiji Ogawa, Masahiro Uota, Kazunori Ikebe, Yasumichi Arai, Kei Kamide, Yasuyuki Gondo, Yukie Masui, Tatsuro Ishizaki, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Kodai Hatta, Yoshinobu Maeda
The sense of taste plays a pivotal role for personal assessment of the nutritional value, safety, and quality of foods. Although it is commonly recognized that taste sensitivity decreases with age, alterations in that sensitivity over time in an old-old population have not been previously reported. Furthermore, no known studies utilized comprehensive variables regarding taste changes and related factors for assessments. Here, we report novel findings from a 3-year longitudinal study model aimed to elucidate taste sensitivity decline and its related factors in old-old individuals...
October 17, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27741155/searching-for-the-perfect-homeostasis-five-strains-of-bifidobacterium-longum-from-centenarians-have-a-similar-behavior-in-the-production-of-cytokines
#10
Stefania Nicola, Angela Amoruso, Francesca Deidda, Marco Pane, Serena Allesina, Luca Mogna, Mario Del Piano, Giovanni Mogna
GOALS: To investigate the modulation of human cytokines by Bifidobacterium longum strains isolated from Centenarians. In particular, we measured the production of interleukin (IL)-12p70, interferon-γ, IL-17A, and IL-4 from human peripheral blood mononuclear cells after stimulation with live bacteria. BACKGROUND: Probiotics may inhibit pathogens and modulate the immune system, bringing a beneficial effect on human health. Among the probiotic strains, bifidobacteria play a key role in the maturation of the host's immune system...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27708821/using-cognitive-behaviour-therapy-to-explore-resilience-in-the-life-stories-of-16-uk-centenarians
#11
Nimmi Hutnik, Pam Smith, Tina Koch
AIM: In 2010, we interviewed 16 UK centenarians about their lives and later published a paper on the socio-emotional aspects of positive ageing. We were struck by their ability to 'move on' from difficult situations which we recognized conceptually as 'resilience'. In the effort to understand aspects of resilience as portrayed in their stories, we re-examined their data. METHODOLOGY: In the original study, we used participatory action research (PAR) for its storytelling and group process components...
April 2016: Nursing Open
https://www.readbyqxmd.com/read/27650875/sarcopenia-and-osteoporosis-in-portuguese-centenarians
#12
A P da Silva, A Matos, R Ribeiro, Â Gil, A Valente, M Bicho, J Gorjão-Clara
BACKGROUND/OBJECTIVES: To evaluate the prevalence of sarcopenia and osteoporosis in centenarians and its association with body composition and past physical activity (PPA). SUBJECTS/METHODS: We conducted an observational cross-sectional study in a representative nationwide population of 253 Portuguese centenarians. A clinically oriented questionnaire and anthropometric and body composition analysis by bioimpedance were executed. Sarcopenia was determined using a muscle mass (MM) index cutoff ⩽16...
September 21, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27644593/maintenance-of-age-in-human-neurons-generated-by-microrna-based-neuronal-conversion-of-fibroblasts
#13
Christine J Huh, Bo Zhang, Matheus B Victor, Sonika Dahiya, Luis Fz Batista, Steve Horvath, Andrew S Yoo
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neurons that maintain multiple age-associated signatures...
September 20, 2016: ELife
https://www.readbyqxmd.com/read/27643194/os-34-01-association-of-combination-of-hypertension-and-diabetes-with-cognitive-function-among-the-70-years-old-japanese-general-population-from-longitudinal-observation-in-the-sonic-study
#14
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633301/cetp-polymorphisms-confer-genetic-contribution-to-centenarians-of-hainan-south-of-china
#15
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu, Wang-Wei Cai
OBJECTIVE: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. METHODS: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). RESULTS: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0...
September 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27621247/rs2802292-polymorphism-in-the-foxo3a-gene-and-exceptional-longevity-in-two-ethnically-distinct-cohorts
#16
Noriyuki Fuku, Roberto Díaz-Peña, Yasumichi Arai, Yukiko Abe, Helios Pareja-Galeano, Fabián Sanchis-Gomar, Alejandro Santos-Lozano, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Letizia Venturini, Giovanni Ricevuti, Hirose Nobuyoshi, Enzo Emanuele, Alejandro Lucia
OBJECTIVES: Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. STUDY DESIGN AND MAIN OUTCOME MEASURES: Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls)...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27600867/familial-longevity-study-reveals-a-significant-association-of-mitochondrial-dna-copy-number-between-centenarians-and-their-offspring
#17
Yong-Han He, Xiao-Qiong Chen, Dong-Jing Yan, Fu-Hui Xiao, Rong Lin, Xiao-Ping Liao, Yao-Wen Liu, Shao-Yan Pu, Qin Yu, Hong-Peng Sun, Jian-Jun Jiang, Wang-Wei Cai, Qing-Peng Kong
Reduced mitochondrial function is an important cause of aging and age-related diseases. We previously revealed a relatively higher level of mitochondrial DNA (mtDNA) content in centenarians. However, it is still unknown whether such an mtDNA content pattern of centenarians could be passed on to their offspring and how it was regulated. To address these issues, we recruited 60 longevity families consisting of 206 family members (cohort 1) and explored their mtDNA copy number. The results showed that the first generation of the offspring (F1 offspring) had a higher level of mtDNA copy number than their spouses (p < 0...
August 6, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27590044/neuropathology-of-supercentenarians-four-autopsy-case-studies
#18
Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura
Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27558117/effects-of-the-apoe-%C3%AE%C2%B54-allele-and-education-on-cognitive-function-in-japanese-centenarians
#19
Yoshiko Lily Ishioka, Yasuyuki Gondo, Noriyuki Fuku, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yukiko Abe, Yasumichi Arai, Nobuyoshi Hirose
Apolipoprotein E (APOE) ε4 allele and education have been reported to affect the cognitive function in young-old adults. However, the effects and interactions of the ε4 allele and education on cognitive function in very old age, particularly in centenarians, are not well known. We studied 542 Japanese centenarians. Using the data in total of 452 participants (74 men and 378 women, mean age 103.6 ± 3.2 years) who were genotyped and assessed cognitive function with the Mini-Mental States Examination (MMSE), we examined the effects and interactions of the ε4 allele and education on the MMSE score...
August 24, 2016: Age (2005-)
https://www.readbyqxmd.com/read/27555614/gender-aging-and-longevity-in-humans-an-update-of-an-intriguing-neglected-scenario-paving-the-way-to-a-gender-specific-medicine
#20
REVIEW
Rita Ostan, Daniela Monti, Paola Gueresi, Mauro Bussolotto, Claudio Franceschi, Giovannella Baggio
Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and demographic data and stressing the importance of a comprehensive historical perspective and a gene-environment/lifestyle interaction. Gender difference regarding prevalence and incidence of the most important age-related diseases, such as cardiovascular and neurodegenerative diseases, cancer, Type 2 diabetes, disability, autoimmunity and infections, are reviewed and updated with particular attention to the role of the immune system and immunosenescence...
October 1, 2016: Clinical Science (1979-)
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