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https://www.readbyqxmd.com/read/28529533/low-expression-of-cd39-and-cd73-genes-in-centenarians-compared-with-octogenarians
#1
Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor
Ageing involves a progressive decline of the body's regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28499387/evolution-of-the-fourth-stage-of-epidemiologic-transition-in-people-aged-80%C3%A2-years-and-over-population-based-cohort-study-using-electronic-health-records
#2
Nisha C Hazra, Martin Gulliford
BACKGROUND: In the "fourth stage" of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been reported. METHODS: This study aimed to evaluate demographic and health transitions in a population aged 80 years and over in the United Kingdom from 1990 to 2014, using primary care electronic health records. Epidemiological analysis of chronic morbidities and age-related impairments included a cohort of 299,495 participants, with stratified sampling by five-year age group up to 100 years and over...
May 12, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28482934/longevity-in-north-korea-and-south-korea-prevalence-of-centenarians-in-one-the-poorest-and-one-of-the-richest-nations
#3
Daniel Schwekendiek
Over recent decades, economic living conditions have dramatically improved in South Korea, which now represents one of the most developed nations. At the same time, its twin in the North remains one of the poorest countries on earth. Thus, the Korean peninsula represents a unique historical experiment that allows for study of the effects of environment on human development under a variety of ceteris paribus cultural, genetic and climatic conditions. Previous studies comparing the biosocial performances of the two Koreas have focused on indicators such as weight, height, mid-upper arm circumference and age at menarche...
May 9, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/28475220/caring-for-a-centenarian-parent-an-exploratory-study-on-role-strains-and-psychological-distress
#4
Daniela Brandão, Oscar Ribeiro, Mónica Oliveira, Constança Paúl
OBJECTIVES: This study examined the main sources of strain and the presence of psychological distress in a sample of centenarians' children who assumed the role of primary caregivers. METHOD: A sample of 43 children (M age = 67.10 ± 6.67 years; 90.7% female) caring for a centenarian parent was interviewed and asked about their overall caregiving experience. Information on caregiving burden (Zarit Burden Interview) and psychological distress (Hospital Anxiety and Depression Scale) was also obtained...
May 5, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28470872/how-long-do-centenarians-survive-life-expectancy-and-maximum-life-span
#5
Karin Modig, Tomas Andersson, James Vaupel, Roland Rau, Anders Ahlbom
OBJECTIVES: The purpose of this study was to explore the pattern of mortality above the age of 100 years. In particular, we aimed to examine whether Scandinavian data support the theory that mortality reaches a plateau at particularly old ages. Whether the maximum length of life increases with time was also investigated. METHODS: The analyses were based on individual level data on all Swedish and Danish centenarians born from 1870 to 1901; in total 3006 men and 10 963 women were included...
May 4, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28470125/aging-exceptional-longevity-and-comparisons-of-the-hannum-and-horvath-epigenetic-clocks
#6
Nicola J Armstrong, Karen A Mather, Anbupalam Thalamuthu, Margaret J Wright, Julian N Trollor, David Ames, Henry Brodaty, Peter R Schofield, Perminder S Sachdev, John B Kwok
AIM: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. MATERIALS & METHODS: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. RESULTS: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28461103/demographic-genetic-and-phenotypic-characteristics-of-centenarians-in-italy-focus-on-gender-differences
#7
REVIEW
Alberto Montesanto, Francesco De Rango, Chiara Pirazzini, Giulia Guidarelli, Filippo Domma, Claudio Franceschi, Giuseppe Passarino
An impressive and coherent series of epidemiological data from different populations (New England Americans, Mormons, Ashkenazi Jewish, Icelandic, Okinawan Japanese, Italians) suggests that long-lived subjects able to reach the extreme limits of human life, such as centenarians and supercentenarians, represent an extraordinary and informative model to identify the mechanisms responsible for healthy aging and human longevity. In most studies, genetic, demographic and phenotypic characteristics of longevity are discussed separately...
April 28, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28435840/microbial-flora-probiotics-bacillus-subtilis-and-the-search-for-a-long-and-healthy-human-longevity
#8
COMMENT
Facundo Rodriguez Ayala, Carlos Bauman, Sebastián Cogliati, Cecilia Leñini, Marco Bartolini, Roberto Grau
Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming probiotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity...
March 16, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28422270/characteristics-and-incidence-of-chronic-illness-in-community-dwelling-predominantly-male-u-s-veteran-centenarians
#9
Raya Elfadel Kheirbek, Ali Fokar, Nawar Shara, Leakie K Bell-Wilson, Hans J Moore, Edwin Olsen, Marc R Blackman, Maria D Llorente
OBJECTIVES: To assess the incidence of chronic illness and its effect on veteran centenarians. DESIGN: Retrospective longitudinal cohort study. SETTING: United States Veterans Affairs Corporate Data Warehouse (CDW). PARTICIPANTS: Community-dwelling veterans born between 1910 and 1915 who survived to at least age 80 (N = 86,892; 31,121 octogenarians, 52,420 nonagenarians, 3,351 centenarians). MEASUREMENTS: The Kaplan-Meier method was used to estimate cumulative incidence of chronic conditions according to age group...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28419892/plasma-apolipoproteins-and-physical-and-cognitive-health-in-very-old-individuals
#10
Julia Muenchhoff, Fei Song, Anne Poljak, John D Crawford, Karen A Mather, Nicole A Kochan, Zixuan Yang, Julian N Trollor, Simone Reppermund, Kate Maston, Adam Theobald, Susanne Kirchner-Adelhardt, John B Kwok, Robyn L Richmond, Mark McEvoy, John Attia, Peter W Schofield, Henry Brodaty, Perminder S Sachdev
Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease, and longevity. We quantified 7 apolipoproteins in plasma in 1067 individuals aged 56-105 using immunoassays and explored relationships with APOE polymorphism ε2/3/4, vascular health, frailty, and cognition. ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH, and ApoJ decreased from mid-life, although ApoE and ApoJ had U-shaped trends. Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups...
March 1, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28417136/too-old-for-surgery-outcomes-of-hip-fracture-surgery-in-centenarians
#11
Wei Xiang Ng, Ernest Bk Kwek
No abstract text is available yet for this article.
March 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28388449/assessment-of-elemental-background-values-and-their-relation-with-lifespan-indicators-a-comparative-study-of-jining-in-shandong-province-and-guanzhong-area-in-shaanxi-province-northern-china
#12
Shaobin Wang, Kunli Luo, Runxiang Ni, Yuan Tian, Xing Gao
The remarkably high proportions of centenarians are found in the Jining Prefecture in southwestern Shandong province, demonstrating remarkable regional longevity differentiation. In this paper, census data at county-level, samples of drinking water and staple grains in Jining Prefecture were collected. Guanzhong area in Shaanxi Province, a non-longevity region in northern China was chosen as the contrast area. The major and trace elements in the samples were determined by using ICP-MS, ICP-OES and HG-AFS. The major results show that Jinxiang County in Jining Prefecture exhibit obviously higher longevity level than adjacent counties and Chinese average level based on temporal and spatial variation of lifespan indicators...
October 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28378616/effect-of-life-events-social-supports-and-personality-on-mental-status-in-later-life
#13
Kyuho Lee, Marissa Holst, Peter Martin, Leonard W Poon
The goal of this study was to explore the influences of proximal and distal life events on mental status in later life. Additionally, life events were categorized into positive and negative experiences. Data from 208 older adults over 80 years of age from the Georgia Centenarian Study were included in this study. Results from a series of blockwise regression analyses indicated that the number of distal negative life events that older adults had experienced was a predictor of older adults' better mental status...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28329165/four-genome-wide-association-studies-identify-new-extreme-longevity-variants
#14
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T Perls
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to discover longevity-associated variants (LAV) and characterized those LAVs that differentiate survival to extreme age at death (eSAVs) from those LAVs that become more frequent in centenarians because of mortality selection (eg, survival to younger years)...
March 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28315698/worldwide-demography-of-centenarians
#15
REVIEW
Jean-Marie Robine, Sarah Cubaynes
The global number of centenarians should strongly increase during the 21 st century. According to the Population Division of the United Nations it should reach more than 25 million people in 2100. To better understand the dynamics of the emergence and growth of the centenarian population, we focused on four European countries having long chronological series and high quality data about centenarians, Denmark, France, Sweden, and Switzerland, and Japan which has had the highest life expectancy at birth for several years...
March 15, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28286215/thyroid-hormones-in-extreme-longevity
#16
REVIEW
Sabrina Garasto, Alberto Montesanto, Andrea Corsonello, Fabrizia Lattanzio, Sergio Fusco, Giuseppe Passarino, Valeria Prestipino Giarritta, Francesco Corica
The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges...
March 9, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28286214/cognitive-status-in-the-oldest-old-and-centenarians-a-condition-crucial-for-quality-of-life-methodologically-difficult-to-assess
#17
REVIEW
Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti
Human life expectancy and the number of the oldest old are rapidly increasing worldwide. Advanced age is the main risk factor for dementia, representing one of the major causes of disability/dependency among older people with a strong impact on their families/caregivers. Centenarians have reached the extreme limits of human life escaping or delaying the major age-related diseases. Thus, these extraordinary individuals embody the best model to answer the crucial question if cognitive decline and dementia are progressive and unavoidable occurrences of increasing age...
March 9, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28281568/the-adhesion-of-lactobacillus-salivarius-ren-to-a-human-intestinal-epithelial-cell-line-requires-s-layer-proteins
#18
Ran Wang, Lun Jiang, Ming Zhang, Liang Zhao, Yanling Hao, Huiyuan Guo, Yue Sang, Hao Zhang, Fazheng Ren
Lactobacillus salivarius REN, a novel probiotic isolated from Chinese centenarians, can adhere to intestinal epithelial cells and subsequently colonize the host. We show here that the surface-layer protein choline-binding protein A (CbpA) of L. salivarius REN was involved in adherence to the human colorectal adenocarcinoma cell line HT-29. Adhesion of a cbpA deletion mutant was significantly reduced compared with that of wild-type, suggesting that CbpA acts as an adhesin that mediates the interaction between the bacterium and its host...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276619/hospital-admissions-by-the-oldest-old-past-trends-in-one-of-the-most-ageing-countries-in-the-world
#19
Daniela Brandão, Oscar Ribeiro, Alberto Freitas, Constança Paúl
AIM: To examine discharges of octogenarians, nonagenarians and centenarians from Portuguese public hospitals, namely admission type, principal diagnoses, comorbidities and length of stay. METHODS: The present study used administrative data from public acute care hospitals in the Portuguese National Health Service. All discharges of persons aged ≥80 years between 2000 and 2014 were analyzed. HCUP Clinical Classifications Software was considered to aggregate principal diagnosis, and comorbidities were assessed using the Charlson Comorbidity Index computed using International Classification of Diseases 9th Revision Clinical Modification codes...
March 9, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28260154/the-cost-and-mortality-of-hip-fractures-in-centenarians
#20
J Moore, O Carmody, B Carey, J A Harty, D Reidy
BACKGROUND: Centenarians are the fastest rising age group in Ireland. Hip fractures most commonly affect older adults and are associated with significant morbidity and mortality, as well as the financial cost of healthcare resources. Despite this, very little is known regarding hip fractures in centenarians. The aim of this study was to investigate our experience with hip fractures in this group and to record the cost of treating these fractures to identify both the social and economic impact these injuries impose on the health system...
March 4, 2017: Irish Journal of Medical Science
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