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https://www.readbyqxmd.com/read/28049008/the-gut-microbiota-of-centenarians-signatures-of-longevity-in-the-gut-microbiota-profile
#1
REVIEW
Biagi Elena, Simone Rampelli, Silvia Turroni, Sara Quercia, Marco Candela, Patrizia Brigidi
The changing physiology and lifestyle of elderly people affect the gut microbiota composition, the changes of which can, in turn, affect the health maintenance of the ageing host. In a co-evolutionary vision of the relationship between gut microbiota and ageing as an adaptive process of the human superorganism, long-living individuals who get to "successfully" age might be the ones whose microbiota manages to continuously re-establish a mutualistic relationship with the host, adapting to the progressive endogenous and environmental changes...
December 31, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28040447/demographics-phenotypic-health-characteristics-and-genetic-analysis-of-centenarians-in-china
#2
REVIEW
Yi Zeng, Qiushi Feng, Danan Gu, James W Vaupel
After a brief introduction to the background, significance and unique features of the centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity Study (CLHLS), which is the world's largest study of centenarians, nonagenarians, octogenarians, and compatible young-old aged 65-79. Based on the CLHLS data and other relevant studies, we summarize demographic and socioeconomic characteristics as well as self-reported and objectively-tested health indicators of centenarians in China, with an emphasis on gender differences and rural/urban disparities...
December 28, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28038993/inflammaging-and-omics-in-human-longevity
#3
REVIEW
Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi
Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omic data - particularly on glycomics - collected on centenarians, supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli conceptualized as "molecular garbage"; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a "local fire" which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly informative set/combination of omic markers able to better grasp the complex molecular core of inflammaging in elderly and centenarians...
December 27, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28035015/case-studies-in-physiology-maximal-oxygen-consumption-and-performance-in-a-centenarian-cyclist
#4
Veronique Louise Billat, Gilles Dhonneur, Laurence Mille-Hamard, Laurence Le Moyec, Iman Momken, Thierry Launay, Jean-Pierre Koralsztein, Sophie Besse
: The purpose of this study was to examine the physiological characteristics of an elite centenarian cyclist who, at 101 years old, established the one-hour cycling record for individuals ≥ 100 years old (24.25 km) and to determine the physiological factors associated with his performance improvement two years later at 103 years old (26.92 km; +11%). Before each record, he performed an incremental test on a cycling ergometer. For two years, he trained 5,000 km a year with a polarized training that involved cycling 80% of mileage at "light" RPE ≤ 12 and 20% at "hard" RPE ≥ 15 at a cadence between 50 and 70 rpm...
December 29, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27992450/association-between-age-and-the-7-repeat-allele-of-the-dopamine-d4-receptor-gene
#5
Anna Szekely, Eszter Kotyuk, Julianna Bircher, Andrea Vereczkei, David A Balota, Maria Sasvari-Szekely, Zsolt Ronai
Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90-109 years old Californian centenarians, as compared to an ancestry-matched young population...
2016: PloS One
https://www.readbyqxmd.com/read/27986629/circulating-mirnas-and-mirna-shuttles-as-biomarkers-perspective-trajectories-of-healthy-and-unhealthy-aging
#6
REVIEW
Fabiola Olivieri, Miriam Capri, Massimiliano Bonafè, Cristina Morsiani, Hwa Jin Jung, Liana Spazzafumo, Jose Viña, Yousin Suh
Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is expected to allow the discovery of new biomarkers of longevity together with risk factor for the most common ARDs...
December 13, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27966433/operative-outcome-of-hong-kong-centenarians-with-hip-fracture
#7
M Y Cheung, A Wh Ho, S H Wong
INTRODUCTION: International clinical guidelines recommend early surgical treatment for geriatric patients with hip fracture. There are, however, few data concerning the operative outcome of centenarians. This study aimed to report the epidemiology of hip fracture and postoperative mortality rate, and to discuss whether operation is justified in centenarians in Hong Kong. METHODS: This observational study was carried out in all public hospitals of Hong Kong. All patients aged 100 years or above who underwent hip fracture surgery in any public hospital between 1 January 2010 and 31 December 2013 were included...
December 14, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27943354/decade-long-temporal-trends-in-the-utilization-of-preventive-medicines-by-centenarians
#8
S W Narayan, P S Nishtala
WHAT IS KNOWN AND OBJECTIVE: Centenarians represent a population of individuals with delayed disability and are an ideal representation of ageing well; however, studies related to medicine use in this population are scarce. Our study aimed to explore the temporal trends associated with the utilization of preventive medicines in centenarians. METHODS: A repeated cross-sectional analysis was conducted from 1st January 2006 to 31st December 2015 for all individuals ≥100 years old on the date of dispensing, captured in New Zealand's pharmaceutical claims data set...
December 10, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27932301/gh-igf-i-insulin-system-in-centenarians
#9
REVIEW
Giovanni Vitale, Michelangela Barbieri, Marina Kamenetskaya, Giuseppe Paolisso
The endocrine system plays a major role in the regulation of several biological activity and in the ageing process. Evolutionary conservation of GH/IGF-I/insulin pathway from worms to mice and similarities in this system between mice and humans raised expectations that downregulated activity of the GH/IGF-I/insulin pathway could be beneficial for the extension of human life span. Centenarians represent the best example of successful ageing having reached the very extremes of the human life span, escaping and delaying the occurrence of several fatal age-related diseases, such as cancer and cardiovascular diseases...
December 5, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27928230/a-centenarian-transcatheter-aortic-valve-implantation-case
#10
Abdullah Nabi Aslan, Hüseyin Ayhan, Elçin Özdemir, Engin Bozkurt
No abstract text is available yet for this article.
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27919768/proximal-femoral-fractures-in-centenarians-a-retrospective-analysis-of-39-patients
#11
A Morice, N Reina, G Gracia, P Bonnevialle, J-M Laffosse, K Wytrykowski, E Cavaignac, N Bonnevialle
BACKGROUND: A corollary of the current population ageing in France is an increase in proximal femoral fractures (PFFs), particularly among centenarians. The outcomes of PFFs in centenarians in France are unknown. We therefore conducted a retrospective study of centenarians with PFFs both to assess: (1) assess clinical outcomes according to geriatric and trauma scores, (2) and to determine whether routine surgery is warranted. HYPOTHESIS: Morbidity and mortality in a single-centre cohort of centenarians with surgically treated PFFs are consistent with previous reports...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27917918/distinct-epigenomes-in-cd4-t-cells-of-newborns-middle-ages-and-centenarians
#12
Ming Zhao, Jian Qin, Hanqi Yin, Yixin Tan, Wei Liao, Qian Liu, Shuangyan Luo, Min He, Gongping Liang, Yajing Shi, Qing Zhang, Wenjun Cai, Guangliang Yin, Yin Zhou, Jing Wang, Mengying Li, Yi Huang, Aiyun Liu, Haijing Wu, Zhiyong Zhang, Qianjin Lu
Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are unclear. We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4(+)T cells from newborn (NB), middle-aged (MA) and long-lived (LL) individuals to elucidate the molecular changes and their interactions. A total 659 genes showed significantly expression changes across NB, MA and LL individuals, in which we identified four age-related co-expression modules with three hub networks of co-expressed genes and non-coding RNAs...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905975/health-profile-of-centenarians-in-portugal-a-census-based-approach
#13
Oscar Ribeiro, Laetitia Teixeira, Lia Araújo, Constança Paúl
BACKGROUND: The number of centenarians is rapidly increasing in Europe. In Portugal, it has almost tripled over the last 10 years and constitutes one of the fastest-growing segments of the population. This paper aims to describe the health and sociodemographic characteristics of Portuguese centenarians as given in the 2011 census and to identify sex differences. METHODS: All persons living in Portugal mainland and Madeira and Azores islands aged 100 years old at the time of the 2011 census (N = 1,526) were considered...
April 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27890377/corrigendum-to-cetp-polymorphisms-confer-genetic-contribution-to-centenarians-of-hainan-south-of-china-asian-pac-j-trop-med-9-9-2016-872-876
#14
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu
No abstract text is available yet for this article.
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27861536/muscle-related-polymorphisms-mstn-rs1805086-and-actn3-rs1815739-are-not-associated-with-exceptional-longevity-in-japanese-centenarians
#15
Noriyuki Fuku, Rafael Alis, Thomas Yvert, Hirofumi Zempo, Hisashi Naito, Yukiko Abe, Yasumichi Arai, Haruka Murakami, Motohiko Miyachi, Helios Pareja-Galeano, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical...
2016: PloS One
https://www.readbyqxmd.com/read/27845177/demographic-phenotypic-and-genetic-characteristics-of-centenarians-in-okinawa-and-japan-part-1-centenarians-in-okinawa
#16
REVIEW
Bradley J Willcox, Donald Craig Willcox, Makoto Suzuki
A study of elderly Okinawans has been carried out by the Okinawa Centenarian Study (OCS) research group for over four decades. The OCS began in 1975 as a population-based study of centenarians (99-year-olds and older) and other selected elderly persons residing in the main island of the Japanese prefecture of Okinawa. As of 2015, over 1000 centenarians have been examined. By several measures of health and longevity the Okinawans can claim to be the world's healthiest and longest-lived people. In this paper we explore the demographic, phenotypic, and genetic characteristics of this fascinating population...
November 12, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27794564/human-exceptional-longevity-transcriptome-from-centenarians-is-distinct-from-septuagenarians-and-reveals-a-role-of-bcl-xl-in-successful-aging
#17
Consuelo Borras, Kheira M Abdelaziz, Juan Gambini, Eva Serna, Marta Inglés, Monica de la Fuente, Idoia Garcia, Ander Matheu, Paula Sanchís, Angel Belenguer, Alessandra Errigo, Juan-Antonio Avellana, Ana Barettino, Carla Lloret-Fernández, Nuria Flames, Gianni Pes, Leocadio Rodriguez-Mañas, Jose Viña
Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians when compared with septuagenarians and young people. Sub-network analysis led us to identify Bcl - xL as an important gene up-regulated in centenarians. It is involved in the control of apoptosis, cellular damage protection and also in modulation of immune response, all associated to healthy aging...
October 28, 2016: Aging
https://www.readbyqxmd.com/read/27754234/os-34-01-association-of-combination-of-hypertension-and-diabetes-with-cognitive-function-among-the-70-years-old-japanese-general-population-from-longitudinal-observation-in-the-sonic-study
#18
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748531/longitudinal-study-of-factors-affecting-taste-sense-decline-in-old-old-individuals
#19
T Ogawa, M Uota, K Ikebe, Y Arai, K Kamide, Y Gondo, Y Masui, T Ishizaki, C Inomata, H Takeshita, Y Mihara, K Hatta, Y Maeda
The sense of taste plays a pivotal role for personal assessment of the nutritional value, safety and quality of foods. Although it is commonly recognised that taste sensitivity decreases with age, alterations in that sensitivity over time in an old-old population have not been previously reported. Furthermore, no known studies utilised comprehensive variables regarding taste changes and related factors for assessments. Here, we report novel findings from a 3-year longitudinal study model aimed to elucidate taste sensitivity decline and its related factors in old-old individuals...
January 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27741155/searching-for-the-perfect-homeostasis-five-strains-of-bifidobacterium-longum-from-centenarians-have-a-similar-behavior-in-the-production-of-cytokines
#20
Stefania Nicola, Angela Amoruso, Francesca Deidda, Marco Pane, Serena Allesina, Luca Mogna, Mario Del Piano, Giovanni Mogna
GOALS: To investigate the modulation of human cytokines by Bifidobacterium longum strains isolated from Centenarians. In particular, we measured the production of interleukin (IL)-12p70, interferon-γ, IL-17A, and IL-4 from human peripheral blood mononuclear cells after stimulation with live bacteria. BACKGROUND: Probiotics may inhibit pathogens and modulate the immune system, bringing a beneficial effect on human health. Among the probiotic strains, bifidobacteria play a key role in the maturation of the host's immune system...
November 2016: Journal of Clinical Gastroenterology
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