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https://www.readbyqxmd.com/read/29337900/age-related-epigenetic-derangement-upon-reprogramming-and-differentiation-of-cells-from-the-elderly
#1
REVIEW
Francesco Ravaioli, Maria G Bacalini, Claudio Franceschi, Paolo Garagnani
Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated...
January 16, 2018: Genes
https://www.readbyqxmd.com/read/29337038/back-to-the-future-epigenetic-clock-plasticity-towards-healthy-aging
#2
REVIEW
Ken Declerck, Wim Vanden Berghe
Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age faster than others, whereas centenarians seem to have a slower aging process. Therefore, a biochemical biomarker reflecting the relative biological age would be helpful to predict an individual's health status and aging disease risk. Although it is already known for years that cumulative epigenetic changes occur upon aging, DNA methylation patterns were only recently used to construct an epigenetic clock predictor for biological age, which is a measure of how well your body functions compared to your chronological age...
January 11, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29286510/comparative-analysis-the-frequency-and-spectrum-of-chromosome-aberrations-in-irradiated-in-vitro-peripheral-blood-lymphocytes-of-the-elderly-and-centenarians-from-kyiv
#3
O O Talan, O V Shemetun, O M Demchenko, M S Papuga, M A Pilinska
OBJECTIVE: To establish and compare the frequency and spectrum of chromosome aberrations under X radiation exposure in vitro in dose 0.25 Gy peripheral blood lymphocytes of the elderly and centenarians. MATERIAL AND METHODS: Material of cytogenetic research were peripheral blood lymphocytes from 11 elderly and 10 centenarians, which were irradiated in vitro in dose 0.25 Gy and cultured by generally accepted semi micromethod; slides of metaphase chromosomes were GTG stained and analyzed under the microscope with magnification x 1000...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29276708/association-between-sleep-patterns-and-health-in-families-with-exceptional-longevity
#4
Lavy Klein, Tina Gao, Nir Barzilai, Sofiya Milman
Background: Sleep patterns such as longer sleep duration or napping are associated with poor health outcomes. Although centenarians and their offspring demonstrate a delayed onset of age-related diseases, it is not known whether they have healthier sleep patterns or are protected against the negative effects of sleep disturbances. Methods: Data on sleep patterns and health history were collected from Ashkenazi Jewish subjects of the Longevity Genes Project using standardized questionnaires...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29259496/immunosenescence-in-aging-between-immune-cells-depletion-and-cytokines-up-regulation
#5
REVIEW
Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi, Rosalba Buquicchio
Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29235077/metabolic-syndrome-and-disability-in-chinese-nonagenarians-and-centenarians
#6
Ming Yang, Hanyue Xu, Ling Yang, Jiaojiao Jiang, Birong Dong
BACKGROUND: Little is known about the relationship between metabolic syndrome (MetS) and disability in the oldest old. AIMS: To investigate the possible association between MetS and disability among community-dwelling older adults aged ≥ 90 years. METHODS: This was a secondary analysis of a cross-sectional study. MetS was defined by the International Diabetes Federation Criteria. Activities of daily living (ADL) and instrumental activities of daily living (IADL) disabilities were evaluated using the physical self-maintenance scale and the Lawton-Brody IADL scale, respectively...
December 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29229012/mixed-methods-quantitative-qualitative-study-of-29-nonagenarians-and-centenarians-in-rural-southern-italy-focus-on-positive-psychological-traits
#7
Anna Scelzo, Salvatore Di Somma, Paola Antonini, Lori P Montross, Nicholas Schork, David Brenner, Dilip V Jeste
OBJECTIVE: This was a study of positive psychological traits in a group of rural Italians aged 90 to 101 years, and their children or other family members. DESIGN: Mixed-methods quantitative (standardized rating scales) and qualitative (semi-structured interviews) study. SETTING: Study participants' homes in nine villages in the Cilento region of southern Italy. PARTICIPANTS: Twenty-nine nonagenarians and centenarians and 51 family members aged 51-75 years, selected by their general practitioners as a part of a larger study called CIAO (Cilento Initiative on Aging Outcomes)...
December 12, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29227965/human-longevity-25-genetic-loci-associated-in-389-166-uk-biobank-participants
#8
Luke C Pilling, Chia-Ling Kuo, Kamil Sicinski, Jone Tamosauskaite, George A Kuchel, Lorna W Harries, Pamela Herd, Robert Wallace, Luigi Ferrucci, David Melzer
We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic hormone receptor)...
December 6, 2017: Aging
https://www.readbyqxmd.com/read/29222883/the-geriatric-nutritional-risk-index-predicts-mortality-in-nonagenarians-and-centenarians-receiving-home-care
#9
Hui Wang, Shan Hai, Yan Zhou, Ping Liu, Bi-Rong Dong
BACKGROUND AND OBJECTIVES: The increasing prevalence of malnutrition in old people is related to the risk of illness and death. A number of screening tools to detect malnutrition have been used in the elderly to assess nutritional status and predict prognosis. The aim of the present study was to investigate the ability of the Geriatric Nutritional Risk Index (GNRI) to assess nutritional status and predict mortality in very old home-care people by using a cross-sectional study of Chinese older people aged 90-105 years...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29220705/therapeutic-landscapes-and-longevity-wellness-tourism-in-bama
#10
Liyuan Huang, Honggang Xu
Due to the rising demand for healthcare products and concern over environmental pollution, wellness tourism has been booming in China in recent years. The therapeutic landscape theory provides a multi-scale interpretation of wellness tourism to explore how wellness tourists achieve health in healing places. By presenting the results of 83 interviews conducted in Bama, China, this study reveals that the "longevity village" Bama, endorsed by centenarians, provides a retreat that combines natural beauty and a harmonious neighbourhood for wellness tourists...
November 28, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29209360/assortative-mating-by-ethnicity-in-longevous-families
#11
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy L Andersen, Thomas T Perls
Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 spouse pairs spanning two generations, while in the NECS we used data from 102 spouse pairs including offspring of centenarians. We used principal components of genome-wide genotype data to demonstrate strong evidence of ancestry-based assortative mating in spouse pairs of the older generation and also confirm the decreasing trend of endogamy in more recent generations...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29170765/historical-evolution-of-old-age-mortality-and-new-approaches-to-mortality-forecasting
#12
Leonid A Gavrilov, Natalia S Gavrilova, Vyacheslav N Krut'ko
Knowledge of future mortality levels and trends is important for actuarial practice but poses a challenge to actuaries and demographers. The Lee-Carter method, currently used for mortality forecasting, is based on the assumption that the historical evolution of mortality at all age groups is driven by one factor only. This approach cannot capture an additive manner of mortality decline observed before the 1960s. To overcome the limitation of the one-factor model of mortality and to determine the true number of factors underlying mortality changes over time, we suggest a new approach to mortality analysis and forecasting based on the method of latent variable analysis...
January 2017: Living to 100 Monograph
https://www.readbyqxmd.com/read/29143599/epistasis-physical-capacity-related-genes-and-exceptional-longevity-fndc5-gene-interactions-with-candidate-genes-foxoa3-and-apoe
#13
Noriyuki Fuku, Roberto Díaz-Peña, Yasumichi Arai, Yukiko Abe, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Carlos Spuch, José A Serra-Rexach, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
BACKGROUND: Forkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the presence of 'modifier genes', may contribute to explain the missing heritability of complex phenotypes such as EL. We assessed the potential association of epistasis among candidate polymorphisms related to physical capacity, as well as antioxidant defense and cardiometabolic traits, and EL in the Japanese population...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29120382/factors-associated-with-activities-of-daily-life-disability-among-centenarians-in-rural-chongqing-china-a-cross-sectional-study
#14
Tingting Wu, Lu Lu, Li Luo, Yingqi Guo, Liying Ying, Qingliu Tao, Huan Zeng, Lingli Han, Zumin Shi, Yong Zhao
OBJECTIVE: This study aims to ascertain the health and lifestyle factors associated with the activities of daily living (ADL) disability of centenarians in rural Chongqing, China. METHOD: 564 centenarians living in rural Chongqing were selected for this cross-sectional study. Demographic characteristics and self-reported lifestyle factors were obtained from face-to-face interviews. ADL disability was measured using the Katz Activities of Daily Living Scale. RESULT: Among the respondents, 65...
November 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29106492/centenarians-differ-in-their-comorbidity-trends-during-the-6-years-before-death-compared-to-individuals-who-died-in-their-80s-or-90s
#15
Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger
Background: While compression of morbidity has now been studied in multiple cohorts, we hypothesize that centenarians might also have fewer chronic conditions as well. We assume that individuals who die as centenarians have less comorbidities and have a less steep rise of the number of comorbidities over the final years before death compared to those who died as nonagenarians (90-99 years) or octogenarians (80-89 years of age). Methods: This German cohort study used health insurance data...
June 29, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29102185/relationship-between-lifespan-indicators-and-elemental-background-values-a-case-study-in-guangdong-province-china
#16
Haixia Pu, Kunli Luo, Shixi Zhang, Yajun Du, Chao Zhao
There was a significant difference in the distribution of centenarians at county-level in Guangdong Province, China. To carry out an integrated analysis on elemental background values and their relation to lifespan level, samples of environmental media such as drinking water, staple rice and soil were collected in ten counties (non-longevity and longevity areas) in Guangdong Province. Meanwhile, lifespan indicators were calculated based on census data in 2010: the percentage of population aged 80 to 90years (octogenarian index, 80-90%, OI%), the percentage of population aged 90 to 100years (longevity index, 90-100%, LI%), centenarians per one hundred thousand inhabitants (CH)...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096878/centenarians-as-a-model-to-discover-genetic-and-epigenetic-signatures-of-healthy-ageing
#17
REVIEW
Annibale Alessandro Puca, Chiara Spinelli, Giulia Accardi, Francesco Villa, Calogero Caruso
Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. So, according to the concept of developmental plasticity, establishment of a longevity phenotype requires a combination of stochastic and non-stochastic events that modulate the genetic substrate and leads to a different outcome...
October 30, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29090332/a-systematic-review-of-vitamin-d-status-in-southern-european-countries
#18
REVIEW
Yannis Manios, George Moschonis, Christina-Paulina Lambrinou, Konstantina Tsoutsoulopoulou, Panagiota Binou, Alexandra Karachaliou, Christina Breidenassel, Marcela Gonzalez-Gross, Mairead Kiely, Kevin D Cashman
PURPOSE: Despite an acknowledged dearth of data on serum 25-hydroxyvitamin D (25(OH)D) concentrations from Southern European countries, inter-country comparison is hampered by inconsistent data reporting. The purpose of the current study was to conduct a systematic literature review of available data on serum 25(OH)D concentrations and estimate vitamin D status in Southern European and Eastern Mediterranean countries, both at a population level and within key population subgroups, stratified by age, sex, season and country...
October 31, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29071456/regional-distribution-of-longevity-population-and-elements-in-drinking-water-in-jiangjin-district-chongqing-city-china
#19
Yonglin Liu, Yuyang Yuan, Kunli Luo
In order to determine the spatial variation of longevity population and elements contained in the drinking water of longevity region in Jiangjin and investigate the relationship between the elements in drinking water and longevity, population censuses on township level and 98 drinking water samples from Jiangjin District, Chongqing City in West China were collected and analyzed. Population statistics on township level showed that the number of centenarians per 100,000 inhabitants (OC), centenarity index (CI), and number of centenarians per 10,000 over 65-year-old subjects (UC) present obvious geographic distribution properties, generally Central region > Northern region > Southern region (Kruskal-Wallis test, p < 0...
October 25, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29060976/-status-of-daily-life-activities-and-respective-risk-factors-among-centenarian-population-in-hainan-province
#20
Y Yao, Y L Zhao, S S Yang, M Liu, J H Wang, L Wu, Y Y Wang, J Zeng, J Li, F X Luan, Y He
Objective: To investigate the Activity of Daily life (ADL) among individuals aged 100 and above, in Hainan. Methods: From June 2014 to December 2016, a community-based cross-sectional study was conducted among individuals aged 100 and over in Hainan province. Data regarding basic information, ADL, prevalence of major age-related diseases was collected in this population. Loss of ADL among these centenarians was described and its determinants examined. Results: The prevalence of ADL loss in centenarian population was 72...
October 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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