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Sarah Marone, Katherine Bloore, Paola Sebastiani, Christopher Flynn, Brittany Leonard, Kelsey Whitaker, Marilyn Mostowy, Thomas Perls, Stacy L Andersen
Objectives: Purpose in life (PIL), a feeling of meaning and direction in life, is associated with favorable health outcomes including lower mortality and reduced risk of disease, disability, and cognitive impairment. Since centenarian offspring have been shown to have long health spans we sought to examine whether they have higher PIL than individuals without familial longevity. Method: We compared PIL scores from the Ryff Scales of Psychological Well-Being in centenarian offspring from the New England Centenarian Study (N=361, mean age=82...
March 7, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Yao He, Yali Zhao, Yao Yao, Shanshan Yang, Jing Li, Miao Liu, Xiaoping Chen, Jianhua Wang, Qiao Zhu, Xiaoying Li, Fu Zhang, Fuxin Luan
No abstract text is available yet for this article.
February 28, 2018: International Journal of Epidemiology
Yi Huang, Mark Rosenberg, Yingli Wang
Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea...
February 17, 2018: International Journal of Biometeorology
Mauro Tettamanti, Gabriella Marcon
PURPOSE: Centenarians, a segment of the population which some 50 years ago comprised only a few individuals, now count thousands in many countries, and demographic projections forecast that this growth will continue. The study of this new population will give us new information on extreme longevity and help prepare for their health and social needs. The aim of the Centenari a Trieste study is to describe the health and health service use by centenarians, with specific focus on cognitive status...
February 8, 2018: BMJ Open
Cheol Min Shin, Dong Ho Lee
No abstract text is available yet for this article.
January 2018: Clinical Endoscopy
Qian Zeng, Xiaoping Chen, Chaoxue Ning, Qiao Zhu, Yao Yao, Yali Zhao, Fuxin Luan
BACKGROUND: Human aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from centenarians. METHODS: Using Illumina 450 K Methylation BeadChip microarray assays, we carried out a pool-based, epigenome-wide investigation of DNA methylation of blood samples from 12 centenarians and 12 healthy controls...
February 2, 2018: BMC Medical Genomics
Motonori Nagasawa, Yoichi Takami, Hiroshi Akasaka, Mai Kabayama, Satomi Maeda, Serina Yokoyama, Taku Fujimoto, Yoichi Nozato, Yuki Imaizumi, Masao Takeda, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Hiromi Rakugi
AIM: The objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults. METHODS: The volunteer older adults, aged approximately 83 years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants...
February 2, 2018: Geriatrics & Gerontology International
Susan G Dorsey, Barbara M Resnick, Cynthia L Renn
Chronic pain has become a public health epidemic based on the number of Americans affected and its associated health care costs. Unfortunately, there are few efficacious treatments to manage chronic pain and as the population of older adults and centenarians who are at high risk for chronic pain continues to grow, the chronic pain epidemic will continue to worsen unless new therapeutic strategies are discovered. In the current era of precision medicine, there is a major emphasis being placed on the use of self-management and omics to discover new therapeutic targets and design treatment strategies that are tailored to the individual patient...
January 1, 2018: Research in Gerontological Nursing
A Sudlow, H Tuffaha, A T Stearns, I A Shaikh
Introduction An increasing proportion of the population is living into their nineties and beyond. These high risk patients are now presenting more frequently to both elective and emergency surgical services. There is limited research looking at outcomes of general surgical procedures in nonagenarians and centenarians to guide surgeons assessing these cases. Methods A retrospective analysis was conducted of all patients aged ≥90 years undergoing elective and emergency general surgical procedures at a tertiary care facility between 2009 and 2015...
January 24, 2018: Annals of the Royal College of Surgeons of England
Laura Bonfanti, Silvia Buratti, Luigi Vignali, Giuseppe Lippi, Franco Masini, Michele Bianconcini, Gianfranco Cervellin
A 101 years-old woman was admitted to our Emergency Department (ED) for acute dyspnea which onset nearly two hours before presentation. She had been on hydrochlorothyazyde-amiloride therapy due to mild hypertension. No other relevant features were present in the clinical history. The old lady had never been admitted to the hospital, and she was still living alone. A few days before hospital admission, one of the daughters became ill, so that a caregiver was paid for assisting her 12/24. This new circumstance was reluctantly accepted by the old lady...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
Ming Yang, Linlin Xie, Xiu Liu, Qiukui Hao, Jiaojiao Jiang, Birong Dong
Recent studies have revealed the prognostic role of the gamma gap, the total serum proteins concentration minus the albumin concentration, for predicting all-cause mortality among adults. This study aims to investigate the relationship between the gamma gap and all-cause mortality among nonagenarians and centenarians via a secondary data analysis of a prospective observational study. The analysis included 801 participants (260 men and 541 women, mean age: 93.7 ± 3.5 years), 46 of which were lost at the 4-year follow-up...
January 18, 2018: Scientific Reports
Francesco Ravaioli, Maria G Bacalini, Claudio Franceschi, Paolo Garagnani
Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated...
January 16, 2018: Genes
Ken Declerck, Wim Vanden Berghe
Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age faster than others, whereas centenarians seem to have a slower aging process. Therefore, a biochemical biomarker reflecting the relative biological age would be helpful to predict an individual's health status and aging disease risk. Although it is already known for years that cumulative epigenetic changes occur upon aging, DNA methylation patterns were only recently used to construct an epigenetic clock predictor for biological age, which is a measure of how well your body functions compared to your chronological age...
January 11, 2018: Mechanisms of Ageing and Development
O O Talan, O V Shemetun, O M Demchenko, M S Papuga, M A Pilinska
OBJECTIVE: To establish and compare the frequency and spectrum of chromosome aberrations under X radiation exposure in vitro in dose 0.25 Gy peripheral blood lymphocytes of the elderly and centenarians. MATERIAL AND METHODS: Material of cytogenetic research were peripheral blood lymphocytes from 11 elderly and 10 centenarians, which were irradiated in vitro in dose 0.25 Gy and cultured by generally accepted semi micromethod; slides of metaphase chromosomes were GTG stained and analyzed under the microscope with magnification x 1000...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
Lavy Klein, Tina Gao, Nir Barzilai, Sofiya Milman
Background: Sleep patterns such as longer sleep duration or napping are associated with poor health outcomes. Although centenarians and their offspring demonstrate a delayed onset of age-related diseases, it is not known whether they have healthier sleep patterns or are protected against the negative effects of sleep disturbances. Methods: Data on sleep patterns and health history were collected from Ashkenazi Jewish subjects of the Longevity Genes Project using standardized questionnaires...
2017: Frontiers in Medicine
Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi, Rosalba Buquicchio
Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility...
2017: Clinical and Molecular Allergy: CMA
Ming Yang, Hanyue Xu, Ling Yang, Jiaojiao Jiang, Birong Dong
BACKGROUND: Little is known about the relationship between metabolic syndrome (MetS) and disability in the oldest old. AIMS: To investigate the possible association between MetS and disability among community-dwelling older adults aged ≥ 90 years. METHODS: This was a secondary analysis of a cross-sectional study. MetS was defined by the International Diabetes Federation Criteria. Activities of daily living (ADL) and instrumental activities of daily living (IADL) disabilities were evaluated using the physical self-maintenance scale and the Lawton-Brody IADL scale, respectively...
December 12, 2017: Aging Clinical and Experimental Research
Anna Scelzo, Salvatore Di Somma, Paola Antonini, Lori P Montross, Nicholas Schork, David Brenner, Dilip V Jeste
OBJECTIVE: This was a study of positive psychological traits in a group of rural Italians aged 90 to 101 years, and their children or other family members. DESIGN: Mixed-methods quantitative (standardized rating scales) and qualitative (semi-structured interviews) study. SETTING: Study participants' homes in nine villages in the Cilento region of southern Italy. PARTICIPANTS: Twenty-nine nonagenarians and centenarians and 51 family members aged 51-75 years, selected by their general practitioners as a part of a larger study called CIAO (Cilento Initiative on Aging Outcomes)...
January 2018: International Psychogeriatrics
Luke C Pilling, Chia-Ling Kuo, Kamil Sicinski, Jone Tamosauskaite, George A Kuchel, Lorna W Harries, Pamela Herd, Robert Wallace, Luigi Ferrucci, David Melzer
We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8 ), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic hormone receptor)...
December 6, 2017: Aging
Hui Wang, Shan Hai, Yan Zhou, Ping Liu, Bi-Rong Dong
BACKGROUND AND OBJECTIVES: The increasing prevalence of malnutrition in old people is related to the risk of illness and death. A number of screening tools to detect malnutrition have been used in the elderly to assess nutritional status and predict prognosis. The aim of the present study was to investigate the ability of the Geriatric Nutritional Risk Index (GNRI) to assess nutritional status and predict mortality in very old home-care people by using a cross-sectional study of Chinese older people aged 90-105 years...
2018: Asia Pacific Journal of Clinical Nutrition
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