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Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
Gürkan Kayabaşoglu, Aytug Altundag, Dilcan Kotan, Denizhan Dizdar, Recep Kaymaz
Olfactory dysfunction and migraine has been associated for a long time. In this study, we planned to compare olfactory functions in patients with migraine and osmophobia with patients having migraine but no osmophobia, in addition with a normal control group using "Sniffin' Sticks" test. The main distinction of this study is that all qualitative and quantitative properties of olfactory functions; threshold, discrimination and identification, are evaluated separately and jointly. Thirty healthy person aged between 16 and 56 (18 women, 12 men) and 60 migraine patients aged between 15 and 54 (39 women, 21 man) were included in the study...
August 30, 2016: European Archives of Oto-rhino-laryngology
Fabrizia Caminiti, Simona De Salvo, Domenica Nunnari, Placido Bramanti, Rosella Ciurleo, Francesca Granata, Silvia Marino
Parosmia has been described in neurological disorders, including temporal epilepsy. We reported a case of parosmia associated with unilateral hyposmia and mesial temporal sclerosis. We assessed the olfactory function by using Sniffin' sticks test and olfactory event-related potentials (OERPs). The findings of unilateral deficit of identification associated with parosmia only in the side ipsilateral to mesial temporal sclerosis area, that involves temporal olfactory regions responsible for higher level of smell processing, suggest a central genesis of olfactory disorders...
August 2016: Neurocase
Jörn Lötsch, Alfred Ultsch, Maren Eckhardt, Caroline Huart, Philippe Rombaux, Thomas Hummel
The presence of cerebral lesions in patients with neurosensory alterations provides a unique window into brain function. Using a fuzzy logic based combination of morphological information about 27 olfactory-eloquent brain regions acquired with four different brain imaging techniques, patterns of brain damage were analyzed in 127 patients who displayed anosmia, i.e., complete loss of the sense of smell (n = 81), or other and mechanistically still incompletely understood olfactory dysfunctions including parosmia, i...
2016: NeuroImage: Clinical
DaHai Yang, Jian Wang, DaoFeng Ni, JianFeng Liu, Xin Wang
To cross-culturally adapt the Questionnaire of olfactory disorders (QOD) into a Chinese version, and then evaluate its reliability and validity for testing patients with olfactory dysfunction. A Chinese version of the QOD was evaluated for test-retest reliability, split-half reliability, and internal consistency. The validity analysis included components of content validity and criterion-related validity, as well as comparisons between The Medical Outcomes Study's36-Item ShortForm Health Survey(SF-36)questionnaire and the WHO Quality of Life-BREF (WHOQOL-BREF)questionnaire...
October 2016: European Archives of Oto-rhino-laryngology
J Frasnelli, M Laguë-Beauvais, J LeBlanc, A Y Alturki, M C Champoux, C Couturier, K Anderson, J Lamoureux, J Marcoux, S Tinawi, J Dagher, M Maleki, M Feyz, E de Guise
OBJECTIVE: Traumatic brain injury (TBI) represents a significant public health problem and is associated with a high rate of mortality and morbidity. Although TBI is amongst the most common causes of olfactory dysfunction the relationship between injury severity and olfactory problems has not yet been investigated with validated and standardized methods in the first days following the TBI. METHODS: We measured olfactory function in 63 patients admitted with TBI within the first 12 days following the trauma by means of the Sniffin' Sticks identification test (quantitative assessment) and a parosmia questionnaire (qualitative assessment)...
January 2016: Clinical Neurology and Neurosurgery
Carl M Philpott, Duncan Boak
Olfactory disorders are believed to affect 5% of the general population and have been shown to bear significant psychosocial consequences to sufferers. Although more common than blindness and profound deafness in the United Kingdom, the impact of these disorders has not been assessed to date and the plight of British patients has yet to be quantified. In 2012, a patient support organization, Fifth Sense, was founded to provide information and support to sufferers of chemosensory disorders. Following a recent members conference, a survey of the membership was conducted anonymously using a series of questions based on an existing olfactory disorders questionnaire...
October 2014: Chemical Senses
Ahmed A Othman, George Haig, Hana Florian, Charles Locke, Lev Gertsik, Sandeep Dutta
AIMS: ABT-288 is a potent and selective H3 receptor antagonist with procognitive effects in several preclinical models. In previous studies, 3 mg once daily was the maximal tolerated dose in healthy volunteers. This study characterized the safety, tolerability and pharmacokinetics of ABT-288 in stable subjects with schizophrenia. METHODS: This was a randomized, double-blind, placebo-controlled, dose-escalating study of ABT-288 (10 dose levels, from 1 to 60 mg once daily for 14 days) in stable subjects with schizophrenia treated with an atypical antipsychotic...
June 2014: British Journal of Clinical Pharmacology
(no author information available yet)
The objective of the present study was to analyse the frequency and specific features of olfactory dysfunction associated with various diseases of the nose and paranasal sinuses in pregnant women and patients with psychic disorders. Among the patients presenting with various forms of exterior nasal deformities, the olfactory thresholds were especially elevated in those suffering from rhinoscoliosis due to deflection of the nasal septum and disturbances of nasal breathing. Moreover, the elevation of olfactory thresholds was documented practically in all the patients with acute sinusitis and in 76...
2013: Vestnik Otorinolaringologii
Antje Welge-Lüssen
The incidence of olfactory disorders is appoximately 1-2% and they can seriously impact on the quality of life. Quantitative disorders (hyposmia, anosmia) are distinguished from qualitative disorders (parosmia, phantosmia). Olfactory disorders are classified according to the etiology and therapy is planned according to the underlying pathophysiology. In ENT patients olfactory disorders caused by sinonasal diseases are the most common ones, followed by postviral disorders. Therapy consists of topical and systemic steroids, whereas systemic application seems to be of greater value...
2005: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
Basile N Landis, Ilona Croy, Antje Haehner
Qualitative olfactory disorders such as parosmia and phantosmia are not well investigated. In particular, the causes and treatment options for phantosmia are largely unknown. We report a case of long lasting phantosmia that disappeared under anti-depressive treatment, raising the question to what extent certain forms of qualitative olfactory disorders are an early symptom of depression.
2012: Neurocase
Claudia Neuland, Thomas Bitter, Heike Marschner, Hilmar Gudziol, Orlando Guntinas-Lichius
OBJECTIVES/HYPOTHESIS: To measure health-related and olfaction-related quality of life (QoL) in patients with permanent, severe hyposmia or functional anosmia. STUDY DESIGN: A case study in a university ENT department of patients with severe olfactory dysfunction defined by Sniffin' Sticks olfactory test kit with a score for odor threshold, discrimination, and identification (TDI) < 20 and a dysfunction lasting longer than 6 months. METHODS: Assessment of QoL by using the SF-36 Health Survey questionnaire and the Questionnaire for Olfactory Dysfunction (QOD)...
April 2011: Laryngoscope
T Bitter, F Siegert, H Gudziol, H P Burmeister, H-J Mentzel, T Hummel, C Gaser, O Guntinas-Lichius
Parosmia is a common olfactory disorder. In this condition, odors are perceived in a different quality than usual. This distorted olfactory percept is typically reported to be unpleasant. Little is known about the pathophysiology of this phenomenon. Previous studies demonstrated smaller volumes of the olfactory bulbs in patients with parosmia compared to subjects without parosmia. In order to investigate structural brain alterations in areas beyond the olfactory bulb, in the current study voxel-based morphometry was applied...
March 17, 2011: Neuroscience
Basile N Landis, Johannes Frasnelli, Ilona Croy, Thomas Hummel
OBJECTIVES/HYPOTHESIS: Parosmia and phantosmia relate to distorted odor perceptions. Little is known about their clinical significance. Measuring phantosmia and parosmia is still not possible. Today, assessment of parosmia or phantosmia relies mainly upon the patient's interview and the physician's experience. Therefore, we investigated the clinical usefulness of four structured questions in comparison to the patient's history regarding their accuracy in terms of the presence of odor distortions...
August 2010: Laryngoscope
Thomas Hummel, Jörn Lötsch
OBJECTIVE: To determine appropriate counseling of patients with olfactory dysfunction. DESIGN: Retrospective analysis. SETTING: Interdisciplinary Center for Smell and Taste, University of Dresden Medical School, Technical University of Dresden. PATIENTS: A total of 361 males and 533 females, aged 11 to 84 years, who twice reported to the Interdisciplinary Center for Smell and Taste. MAIN OUTCOME MEASURES: Residual olfactory performance, duration of olfactory loss until first assessment, presence or absence of parosmia or phantosmia, origin of olfactory loss, interval between assessments, age, sex, and smoking habits...
April 2010: Archives of Otolaryngology—Head & Neck Surgery
P Rombaux, S Martinage, C Huart, S Collet
Post-infectious olfactory loss is defined as an olfactory dysfunction in the course of an upper respiratory tract infection. Quantitative olfactory dysfunction is usually moderate to severe, with many patients experiencing a qualitative disorder such as parosmia. Diagnosis is made on the basis of patient history, normal clinical examination (no inflammatory disease in the olfactory cleft) and decreased olfactory function. This paper provides an update of pathophysiology, clinical management and prognosis, and also looks at the clinical characteristic of a cohort of 122 patients from our department...
2009: B-ENT
Wendy M Smith, Terence M Davidson, Claire Murphy
BACKGROUND: Toxic chemical exposures are estimated to account for 1-5% of all olfactory disorders. Both olfactory neurons and taste buds are in direct contact with environmental agents because of their relatively unprotected anatomic locations, thereby making them susceptible to damage from acute and chronic toxic exposures. The aim of this study was to illustrate different aspects of the diagnostic and therapeutic approach to this disorder using a series of case reports and review of the literature...
November 2009: American Journal of Rhinology & Allergy
Monique A M Smeets, Maria G Veldhuizen, Sara Galle, Juul Gouweloos, Anne-Marie J A de Haan, Jesse Vernooij, Floris Visscher, Jan H A Kroeze
OBJECTIVES: To compare health-related quality of life and depression between individuals with an inability to smell (anosmia) and a comparison group of individuals with a normal sense of smell. METHODS: Ninety individuals from an anosmia organization (anosmia based on self-report) were compared to 89 individuals with a normal sense of smell. The SF-36 and Beck Depression Inventory-II-NL (BDI-II-NL) were administered, along with the Questionnaire for Olfactory Dysfunction (QOD) to assess the degree of problems in daily life related to the smell impairment...
November 2009: Rehabilitation Psychology
P Rombaux, T Duprez, T Hummel
The olfactory bulb collects the sensory afferents of the olfactory receptor cells located in the olfactory neuroepithelium. The olfactory bulb ends with the olfactory tract and is closely related to the olfactory sulcus of the frontal lobe. Many studies demonstrated that olfactory bulb volume assessed with magnetic resonance imaging is related to the olfactory function both in normal and pathological conditions. It has been shown that olfactory bulb volume changes with the degree of olfactory dysfunction, that it decreases with the duration of the olfactory loss and that patients with qualitative disorder such as parosmia have smaller olfactory bulbs than patients without parosmia...
March 2009: Rhinology
Shih-Hsiang Lin, Sau-Tung Chu, Ben-Chih Yuan, Chih-Hung Shu
BACKGROUND: Olfactory function is related to the scrutiny of environmental dangers and the tasting of food. However, olfactory dysfunction is not as distinctive as visual loss and may go unnoticed, especially when olfactory function deteriorates slowly. Most studies have used either questionnaires or relatively insensitive tests to assess olfactory dysfunction. Therefore, the objective of this study was to evaluate the frequency of olfactory dysfunction in Taiwan. METHODS: A total of 211 participants were recruited randomly from the community, factories or offices in Taichung City, Taiwan from April 2005 to March 2006...
February 2009: Journal of the Chinese Medical Association: JCMA
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