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https://www.readbyqxmd.com/read/30415748/global-regional-and-national-disability-adjusted-life-years-dalys-for-359-diseases-and-injuries-and-healthy-life-expectancy-hale-for-195-countries-and-territories-1990-2017-a-systematic-analysis-for-the-global-burden-of-disease-study-2017
#1
(no author information available yet)
BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years...
November 10, 2018: Lancet
https://www.readbyqxmd.com/read/30409709/global-regional-and-national-burden-of-motor-neuron-diseases-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#2
(no author information available yet)
BACKGROUND: Understanding how prevalence, incidence, and mortality of motor neuron diseases change over time and by location is crucial for understanding the causes of these disorders and for health-care planning. Our aim was to produce estimates of incidence, prevalence, and disability-adjusted life-years (DALYs) for motor neuron diseases for 195 countries and territories from 1990 to 2016 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016. METHODS: The motor neuron diseases included in this study were amyotrophic lateral sclerosis, spinal muscular atrophy, hereditary spastic paraplegia, primary lateral sclerosis, progressive muscular atrophy, and pseudobulbar palsy...
November 2, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30403937/a-trial-of-a-triple-drug-treatment-for-lymphatic-filariasis
#3
Christopher L King, James Suamani, Nelly Sanuku, Yao-Chieh Cheng, Samson Satofan, Brooke Mancuso, Charles W Goss, Leanne J Robinson, Peter M Siba, Gary J Weil, James W Kazura
BACKGROUND: The World Health Organization has targeted lymphatic filariasis for global elimination by 2020 with a strategy of mass drug administration. This trial tested whether a single dose of a three-drug regimen of ivermectin plus diethylcarbamazine plus albendazole results in a greater sustained clearance of microfilariae than a single dose of a two-drug regimen of diethylcarbamazine plus albendazole and is noninferior to the two-drug regimen administered once a year for 3 years...
November 8, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30361107/population-based-rates-timing-and-causes-of-maternal-deaths-stillbirths-and-neonatal-deaths-in-south-asia-and-sub-saharan-africa-a-multi-country-prospective-cohort-study
#4
(no author information available yet)
BACKGROUND: Modelled mortality estimates have been useful for health programmes in low-income and middle-income countries. However, these estimates are often based on sparse and low-quality data. We aimed to generate high quality data about the burden, timing, and causes of maternal deaths, stillbirths, and neonatal deaths in south Asia and sub-Saharan Africa. METHODS: In this prospective cohort study done in 11 community-based research sites in south Asia and sub-Saharan Africa, between July, 2012, and February, 2016, we conducted population-based surveillance of women of reproductive age (15-49 years) to identify pregnancies, which were followed up to birth and 42 days post partum...
October 22, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30353868/global-regional-and-national-burden-of-migraine-and-tension-type-headache-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#5
(no author information available yet)
BACKGROUND: Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. METHODS: Data were derived from population-based cross-sectional surveys on migraine and tension-type headache...
November 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30340847/forecasting-life-expectancy-years-of-life-lost-and-all-cause-and-cause-specific-mortality-for-250-causes-of-death-reference-and-alternative-scenarios-for-2016-40-for-195-countries-and-territories
#6
Kyle J Foreman, Neal Marquez, Andrew Dolgert, Kai Fukutaki, Nancy Fullman, Madeline McGaughey, Martin A Pletcher, Amanda E Smith, Kendrick Tang, Chun-Wei Yuan, Jonathan C Brown, Joseph Friedman, Jiawei He, Kyle R Heuton, Mollie Holmberg, Disha J Patel, Patrick Reidy, Austin Carter, Kelly Cercy, Abigail Chapin, Dirk Douwes-Schultz, Tahvi Frank, Falko Goettsch, Patrick Y Liu, Vishnu Nandakumar, Marissa B Reitsma, Vince Reuter, Nafis Sadat, Reed J D Sorensen, Vinay Srinivasan, Rachel L Updike, Hunter York, Alan D Lopez, Rafael Lozano, Stephen S Lim, Ali H Mokdad, Stein Emil Vollset, Christopher J L Murray
BACKGROUND: Understanding potential trajectories in health and drivers of health is crucial to guiding long-term investments and policy implementation. Past work on forecasting has provided an incomplete landscape of future health scenarios, highlighting a need for a more robust modelling platform from which policy options and potential health trajectories can be assessed. This study provides a novel approach to modelling life expectancy, all-cause mortality and cause of death forecasts -and alternative future scenarios-for 250 causes of death from 2016 to 2040 in 195 countries and territories...
November 10, 2018: Lancet
https://www.readbyqxmd.com/read/30322649/equity-in-antenatal-care-quality-an-analysis-of-91-national-household-surveys
#7
Catherine Arsenault, Keely Jordan, Dennis Lee, Girmaye Dinsa, Fatuma Manzi, Tanya Marchant, Margaret E Kruk
BACKGROUND: Emerging data show that many low-income and middle-income country (LMIC) health systems struggle to consistently provide good-quality care. Although monitoring of inequalities in access to health services has been the focus of major international efforts, inequalities in health-care quality have not been systematically examined. METHODS: Using the most recent (2007-16) Demographic and Health Surveys and Multiple Indicator Cluster Surveys in 91 LMICs, we described antenatal care quality based on receipt of three essential services (blood pressure monitoring and urine and blood testing) among women who had at least one visit with a skilled antenatal-care provider...
November 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30322648/assessment-of-quality-of-primary-care-with-facility-surveys-a-descriptive-analysis-in-ten-low-income-and-middle-income-countries
#8
Erlyn K Macarayan, Anna D Gage, Svetlana V Doubova, Frederico Guanais, Ephrem T Lemango, Youssoupha Ndiaye, Peter Waiswa, Margaret E Kruk
BACKGROUND: Primary care has the potential to address a large proportion of people's health needs, promote equity, and contain costs, but only if it provides high-quality health services that people want to use. 40 years after the Declaration of Alma-Ata, little is known about the quality of primary care in low-income and middle-income countries. We assessed whether existing facility surveys capture relevant aspects of primary care performance and summarised the quality of primary care in ten low-income and middle-income countries...
November 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30316576/the-bill-melinda-gates-foundation-an-opportunity-to-lead-innovation-in-global-surgery
#9
Rachel Koch, Lina Roa, Jordan Pyda, Monica Kerrigan, Ernest Barthélemy, John G Meara
BACKGROUND: The Bill and Melinda Gates Foundation has made unparalleled contributions to global health and human development by bringing together generous funding, strategic partnerships, and innovative leadership. For the last twenty years, the Gates Foundation has supported the expansion of programs that directly address the fundamental barriers to the advancement of marginalized communities around the globe, with a transformative focus on innovations to combat communicable diseases and to ensure maternal and child health...
October 10, 2018: Surgery
https://www.readbyqxmd.com/read/30309799/effectiveness-of-strategies-to-improve-health-care-provider-practices-in-low-income-and-middle-income-countries-a-systematic-review
#10
Alexander K Rowe, Samantha Y Rowe, David H Peters, Kathleen A Holloway, John Chalker, Dennis Ross-Degnan
BACKGROUND: Inadequate health-care provider performance is a major challenge to the delivery of high-quality health care in low-income and middle-income countries (LMICs). The Health Care Provider Performance Review (HCPPR) is a comprehensive systematic review of strategies to improve health-care provider performance in LMICs. METHODS: For this systematic review we searched 52 electronic databases for published studies and 58 document inventories for unpublished studies from the 1960s to 2016...
November 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30301457/globalisation-and-neoliberalism-as-structural-drivers-of-health-inequities
#11
REVIEW
Rama V Baru, Malu Mohan
In this paper, we draw upon and build on three presentations which were part of the plenary session on 'Structural Drivers of Health Inequities' at the National Conference on Health Inequities in India: Transformative Research for Action, organised by the Achutha Menon Centre for Health Science Studies in Trivandrum, India. The three presentations discussed the influential role played by globalisation and neoliberalism in shaping economic, social and political relationships across developed and developing countries...
October 9, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/30287127/use-of-quantitative-molecular-diagnostic-methods-to-assess-the-aetiology-burden-and-clinical-characteristics-of-diarrhoea-in-children-in-low-resource-settings-a-reanalysis-of-the-mal-ed-cohort-study
#12
James A Platts-Mills, Jie Liu, Elizabeth T Rogawski, Furqan Kabir, Paphavee Lertsethtakarn, Mery Siguas, Shaila S Khan, Ira Praharaj, Arinao Murei, Rosemary Nshama, Buliga Mujaga, Alexandre Havt, Irene A Maciel, Timothy L McMurry, Darwin J Operario, Mami Taniuchi, Jean Gratz, Suzanne E Stroup, James H Roberts, Adil Kalam, Fatima Aziz, Shahida Qureshi, M Ohedul Islam, Pimmada Sakpaisal, Sasikorn Silapong, Pablo P Yori, Revathi Rajendiran, Blossom Benny, Monica McGrath, Benjamin J J McCormick, Jessica C Seidman, Dennis Lang, Michael Gottlieb, Richard L Guerrant, Aldo A M Lima, Jose Paulo Leite, Amidou Samie, Pascal O Bessong, Nicola Page, Ladaporn Bodhidatta, Carl Mason, Sanjaya Shrestha, Ireen Kiwelu, Estomih R Mduma, Najeeha T Iqbal, Zulfiqar A Bhutta, Tahmeed Ahmed, Rashidul Haque, Gagandeep Kang, Margaret N Kosek, Eric R Houpt
BACKGROUND: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study. METHODS: We re-analysed stool specimens from the multisite MAL-ED cohort study of children aged 0-2 years done at eight locations (Dhaka, Bangladesh; Vellore, India; Bhaktapur, Nepal; Naushero Feroze, Pakistan; Venda, South Africa; Haydom, Tanzania; Fortaleza, Brazil; and Loreto, Peru), which included active surveillance for diarrhoea and routine non-diarrhoeal stool collection...
October 1, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30287125/use-of-quantitative-molecular-diagnostic-methods-to-investigate-the-effect-of-enteropathogen-infections-on-linear-growth-in-children-in-low-resource-settings-longitudinal-analysis-of-results-from-the-mal-ed-cohort-study
#13
Elizabeth T Rogawski, Jie Liu, James A Platts-Mills, Furqan Kabir, Paphavee Lertsethtakarn, Mery Siguas, Shaila S Khan, Ira Praharaj, Arinao Murei, Rosemary Nshama, Buliga Mujaga, Alexandre Havt, Irene A Maciel, Darwin J Operario, Mami Taniuchi, Jean Gratz, Suzanne E Stroup, James H Roberts, Adil Kalam, Fatima Aziz, Shahida Qureshi, M Ohedul Islam, Pimmada Sakpaisal, Sasikorn Silapong, Pablo P Yori, Revathi Rajendiran, Blossom Benny, Monica McGrath, Jessica C Seidman, Dennis Lang, Michael Gottlieb, Richard L Guerrant, Aldo A M Lima, Jose Paulo Leite, Amidou Samie, Pascal O Bessong, Nicola Page, Ladaporn Bodhidatta, Carl Mason, Sanjaya Shrestha, Ireen Kiwelu, Estomih R Mduma, Najeeha T Iqbal, Zulfiqar A Bhutta, Tahmeed Ahmed, Rashidul Haque, Gagandeep Kang, Margaret N Kosek, Eric R Houpt
BACKGROUND: Enteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear growth across seven low-resource settings. METHODS: We used quantitative PCR to detect 29 enteropathogens in diarrhoeal and non-diarrhoeal stools collected from children in the first 2 years of life obtained during the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) multisite cohort study...
October 1, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30287051/global-regional-and-national-burden-of-parkinson-s-disease-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#14
(no author information available yet)
BACKGROUND: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. METHODS: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016...
November 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30280646/prediction-of-susceptibility-to-first-line-tuberculosis-drugs-by-dna-sequencing
#15
MULTICENTER STUDY
Caroline Allix-Béguec, Irena Arandjelovic, Lijun Bi, Patrick Beckert, Maryline Bonnet, Phelim Bradley, Andrea M Cabibbe, Irving Cancino-Muñoz, Mark J Caulfield, Angkana Chaiprasert, Daniela M Cirillo, David A Clifton, Iñaki Comas, Derrick W Crook, Maria R De Filippo, Han de Neeling, Roland Diel, Francis A Drobniewski, Kiatichai Faksri, Maha R Farhat, Joy Fleming, Philip Fowler, Tom A Fowler, Qian Gao, Jennifer Gardy, Deborah Gascoyne-Binzi, Ana-Luiza Gibertoni-Cruz, Ana Gil-Brusola, Tanya Golubchik, Ximena Gonzalo, Louis Grandjean, Guangxue He, Jennifer L Guthrie, Sarah Hoosdally, Martin Hunt, Zamin Iqbal, Nazir Ismail, James Johnston, Faisal M Khanzada, Chiea C Khor, Thomas A Kohl, Clare Kong, Sam Lipworth, Qingyun Liu, Gugu Maphalala, Elena Martinez, Vanessa Mathys, Matthias Merker, Paolo Miotto, Nerges Mistry, David A J Moore, Megan Murray, Stefan Niemann, Shaheed V Omar, Rick T-H Ong, Tim E A Peto, James E Posey, Therdsak Prammananan, Alexander Pym, Camilla Rodrigues, Mabel Rodrigues, Timothy Rodwell, Gian M Rossolini, Elisabeth Sánchez Padilla, Marco Schito, Xin Shen, Jay Shendure, Vitali Sintchenko, Alex Sloutsky, E Grace Smith, Matthew Snyder, Karine Soetaert, Angela M Starks, Philip Supply, Prapat Suriyapol, Sabira Tahseen, Patrick Tang, Yik-Ying Teo, Thuong N T Thuong, Guy Thwaites, Enrico Tortoli, Dick van Soolingen, A Sarah Walker, Timothy M Walker, Mark Wilcox, Daniel J Wilson, David Wyllie, Yang Yang, Hongtai Zhang, Yanlin Zhao, Baoli Zhu
BACKGROUND: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear. METHODS: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to the first-line antituberculosis drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents...
October 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30266330/morbidity-and-mortality-due-to-shigella-and-enterotoxigenic-escherichia-coli-diarrhoea-the-global-burden-of-disease-study-1990-2016
#16
Ibrahim A Khalil, Christopher Troeger, Brigette F Blacker, Puja C Rao, Alexandria Brown, Deborah E Atherly, Thomas G Brewer, Cyril M Engmann, Eric R Houpt, Gagandeep Kang, Karen L Kotloff, Myron M Levine, Stephen P Luby, Calman A MacLennan, William K Pan, Patricia B Pavlinac, James A Platts-Mills, Firdausi Qadri, Mark S Riddle, Edward T Ryan, David A Shoultz, A Duncan Steele, Judd L Walson, John W Sanders, Ali H Mokdad, Christopher J L Murray, Simon I Hay, Robert C Reiner
BACKGROUND: Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens that are frequently associated with diarrhoeal disease, and are a significant cause of mortality and morbidity worldwide. The Global Burden of Diseases, Injuries, and Risk Factors study 2016 (GBD 2016) is a systematic, scientific effort to quantify the morbidity and mortality due to over 300 causes of death and disability. We aimed to analyse the global burden of shigella and ETEC diarrhoea according to age, sex, geography, and year from 1990 to 2016...
September 25, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/30245056/smartphone-based-pathogen-diagnosis-in-urinary-sepsis-patients
#17
Lucien Barnes, Douglas M Heithoff, Scott P Mahan, Gary N Fox, Andrea Zambrano, Jane Choe, Lynn N Fitzgibbons, Jamey D Marth, Jeffrey C Fried, H Tom Soh, Michael J Mahan
BACKGROUND: There is an urgent need for rapid, sensitive, and affordable diagnostics for microbial infections at the point-of-care. Although a number of innovative systems have been reported that transform mobile phones into potential diagnostic tools, the translational challenge to clinical diagnostics remains a significant hurdle to overcome. METHODS: A smartphone-based real-time loop-mediated isothermal amplification (smaRT-LAMP) system was developed for pathogen ID in urinary sepsis patients...
October 2018: EBioMedicine
https://www.readbyqxmd.com/read/30243584/estimates-of-the-global-regional-and-national-morbidity-mortality-and-aetiologies-of-lower-respiratory-infections-in-195-countries-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#18
(no author information available yet)
BACKGROUND: Lower respiratory infections are a leading cause of morbidity and mortality around the world. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, provides an up-to-date analysis of the burden of lower respiratory infections in 195 countries. This study assesses cases, deaths, and aetiologies spanning the past 26 years and shows how the burden of lower respiratory infection has changed in people of all ages. METHODS: We used three separate modelling strategies for lower respiratory infections in GBD 2016: a Bayesian hierarchical ensemble modelling platform (Cause of Death Ensemble model), which uses vital registration, verbal autopsy data, and surveillance system data to predict mortality due to lower respiratory infections; a compartmental meta-regression tool (DisMod-MR), which uses scientific literature, population representative surveys, and health-care data to predict incidence, prevalence, and mortality; and modelling of counterfactual estimates of the population attributable fraction of lower respiratory infection episodes due to Streptococcus pneumoniae, Haemophilus influenzae type b, influenza, and respiratory syncytial virus...
September 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/30243583/estimates-of-the-global-regional-and-national-morbidity-mortality-and-aetiologies-of-diarrhoea-in-195-countries-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#19
(no author information available yet)
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis of the burden of diarrhoea in 195 countries. This study assesses cases, deaths, and aetiologies in 1990-2016 and assesses how the burden of diarrhoea has changed in people of all ages. METHODS: We modelled diarrhoea mortality with a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data...
September 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/30235222/exploring-the-roots-of-antagony-in-the-safe-male-circumcision-partnership-in-botswana
#20
Masego Katisi, Marguerite Daniel
BACKGROUND: Partnerships in global health and development governance have been firmly established as a tool to achieve effective outcomes. Botswana implements Safe Male Circumcision (SMC) for HIV prevention through a North-South partnership comprising the local Ministry of Health, US Centers for Disease Control and Prevention (funded by PEPFAR) and Africa Comprehensive HIV/AIDS Partnership (funded by the Bill and Melinda Gates Foundation). The SMC partnership experienced significant antagony and the aim of this paper is to illuminate the actions and processes in the SMC program that contributed to that antagony...
2018: PloS One
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