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Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
Kathleen R Walker, Daniel Williamson, Yves Carrière, Pablo A Reyes-Castro, Steven Haenchen, Mary H Hayden, Eileen Jeffrey Gutierrez, Kacey C Ernst
Aedes aegypti (L.; Diptera: Culicidae) has been established in the southwestern United States for several decades, but relationships between humans and mosquitoes in this arid region are not well-characterized. In August 2012, the outdoor premises of 355 houses within 20 neighborhoods in Tucson, Arizona were surveyed for containers that could provide larval habitat for Ae. aegypti mosquitoes. At the same time, a knowledge, attitudes and practices (KAP) questionnaire was administered to a resident of each house surveyed for immature mosquitoes...
February 19, 2018: Journal of Medical Entomology
Miao He, Z Josh Huang
Understanding brain circuit organization and function requires systematic dissection of its cellular components. With vast cell number and diversity, mammalian nervous systems present a daunting challenge for achieving specific and comprehensive cell type access-prerequisite to circuit analysis. Genetic approaches in the mouse have relied on germline engineering to access marker-defined cell populations. Combinatorial strategies that engage marker intersection, anatomy and projection pattern (e.g. antero-grade and retro-grade viral vectors), and developmental lineage substantially increase the specificity of cell type targeting...
February 19, 2018: Current Opinion in Neurobiology
Ying Pan, Ling-Dong Kong
Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Ulf Persson, J M Norlin
Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
February 22, 2018: Applied Health Economics and Health Policy
Julio A Ramirez
PURPOSE OF REVIEW: The primary challenges in the field of clinical research include a lack of support within existing infrastructure, insufficient number of clinical research training programs and a paucity of qualified mentors. Most medical centers offer infrastructure support for investigators working with industry sponsors or government-funded clinical trials, yet there are a significant amount of clinical studies performed in the field of pneumonia which are observational studies...
February 20, 2018: Current Opinion in Pulmonary Medicine
James Pickett, Cathy Bird, Clive Ballard, Sube Banerjee, Carol Brayne, Katherine Cowan, Linda Clare, Adelina Comas-Herrera, Lynne Corner, Stephanie Daley, Martin Knapp, Louise Lafortune, Gill Livingston, Jill Manthorpe, Natalie Marchant, Jo Moriarty, Louise Robinson, Clare van Lynden, Gill Windle, Bob Woods, Katherine Gray, Clare Walton
OBJECTIVE: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. METHODS: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research...
February 22, 2018: International Journal of Geriatric Psychiatry
Lauren N Ko, Daniela Kroshinsky
BACKGROUND: Although considered an outpatient specialty, dermatology plays an important role in inpatient medicine. We characterized the activity and structure of dermatology consultation services in select U.S. hospitals. METHODS: In this cross sectional study, a 31-question survey was distributed in person to 32 board-certified dermatologists at the 2017 Society of Dermatology Hospitalists meeting. RESULTS: Thirty participants completed the survey (yield 93...
February 22, 2018: International Journal of Dermatology
Michael Naor, Samuel N Heyman, Tarif Bader, Ofer Merin
OBJECTIVE: The Israeli Defense Force (IDF) Medical Corps developed a model of airborne field hospital. This model was structured to deal with disaster settings, requiring self-sufficiency, innovation and flexible operative mode in the setup of large margins of uncertainty regarding the disaster environment. The current study is aimed to critically analyze the experience, gathered in ten such missions worldwide. METHODS: Interviews with physicians who actively participated in the missions from 1988 until 2015 as chief medical officers combined with literature review of principal medical and auxiliary publications in order to assess and integrate information about the assembly of these missions...
October 2017: American Journal of Disaster Medicine
Shaosan Kang, Yansheng Zhao, Lei Wang, Jian Liu, Xi Chen, Xiaofeng Liu, Zhijie Shi, Weixing Gao, Fenghong Cao
Numerous previous studies reported the association of Vitamin D receptor gene Taq I polymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs...
January 23, 2018: Oncotarget
Hongbo Zhao, Jiaoli Yang, Zhenzhen Yu, Hui Shen, Xinlin Huang, Mi Zhang, Teng Long, A Cailing, Wenhui Wang
The current study was designed to quantitatively summarize the evidence for the strength of the associations between common IL-10 functional polymorphisms and skin cancer risk. Relevant publications concerning the associations between common IL-10 functional polymorphisms(-1082G>A, -819C>T and -592C>A) and skin cancer were retrieved by a comprehensive electronic literature search in PubMed, Web of Science, EBSCO, Embase, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Database (CBM)...
January 23, 2018: Oncotarget
Benjamin L Jones, Leanne C Cullen-Unsworth, Richard K F Unsworth
Excess nutrients shift the ecological balance of coastal ecosystems, and this eutrophication is an increasing problem across the globe. Nutrient levels may be routinely measured, but monitoring rarely attempts to determine the source of these nutrients, even though bio-indicators are available. Nitrogen stable isotope analysis in biota is one such bio-indicator, but across the British Isles, this is rarely used. In this study, we provide the first quantitative evidence of the anthropogenic drivers of reduced water quality surrounding seagrass meadows throughout the British Isles using the stable nitrogen isotope δ15 N...
2018: Frontiers in Plant Science
Tiffany Paradis, Etienne St-Louis, Tara Landry, Dan Poenaru
BACKGROUND: The benefits of trauma registries have been well described. The crucial data they provide may guide injury prevention strategies, inform resource allocation, and support advocacy and policy. This has been shown to reduce trauma-related mortality in various settings. Trauma remains a leading cause of mortality in low- and middle-income countries (LMICs). However, the implementation of trauma registries in LMICs can be challenging due to lack of funding, specialized personnel, and infrastructure...
February 21, 2018: Systematic Reviews
Lydia Nakiyingi, Prossy Nakanwagi, Jessica Briggs, Tifu Agaba, Frank Mubiru, Mark Mugenyi, Willy Ssengooba, Moses L Joloba, Yukari C Manabe
BACKGROUND: Smear microscopy lacks sensitivity especially in HIV co-infection, resulting in undiagnosed tuberculosis (TB) and high mortality. The loop-mediated isothermal amplification (TB-LAMP) assay can be staged with minimal infrastructure, is rapid, low cost and detection can be with the naked eye. We assessed feasibility and performance of Eiken TB-LAMP test at point-of-need in TB diagnosis in a high prevalence TB/HIV rural setting in Uganda. METHODS: From October 2013-February 2014, TB-LAMP testing was performed on sputum specimens from outpatient presumptive TB adults at a district hospital and two low-level health centers in Kiboga District where smear microscopy is the available routine diagnostic option...
February 21, 2018: BMC Infectious Diseases
Brian G Rahm, Natalie Morse, Michelle Bowen, Jun Choi, Dhaval Mehta, Sridhar Vedachalam
Like many regions around the world, New York State, USA, faces challenges in meeting wastewater treatment quality standards because of aging infrastructure, limited funding, shifting demographics and increasingly stringent environmental regulations. In recent decades construction of new wastewater treatment and distribution infrastructure in NY has most often occurred in exurban communities and suburban developments that are less dense than traditional urban cores. Here, we examine the role of size and capacity utilization on wastewater treatment effectiveness with respect to critical effluent parameters, and additionally explore which common facility engineering controls influence water quality treatment using a unique dataset of descriptive information...
February 12, 2018: Water Research
Anderson da Costa Armstrong, Ana Marice Teixeira Ladeia, Juracy Marques, Dinani Matoso Fialho de Oliveira Armstrong, Antonio Marconi Leandro da Silva, Jeová Cordeiro de Morais Junior, Aldina Barral, Luis Claudio Lemos Correia, Manoel Barral-Netto, João A C Lima
BACKGROUND: The cardiovascular risk burden among diverse indigenous populations is not totally known and may be influenced by lifestyle changes related to the urbanization process. OBJECTIVES: To investigate the cardiovascular (CV) mortality profile of indigenous populations during a rapid urbanization process largely influenced by governmental infrastructure interventions in Northeast Brazil. METHODS: We assessed the mortality of indigenous populations (≥ 30 y/o) from 2007 to 2011 in Northeast Brazil (Bahia and Pernambuco states)...
February 19, 2018: Arquivos Brasileiros de Cardiologia
Youkang Dong, Rong Zhao, Chunlin Wang, Taipin Guo
BACKGROUND: Osteoporosis is one kind of commonly and frequently occurring global disease accompanying with serious complications. As a branch of the subject of Acupuncture-Tuina, tuina is widely applied for osteoporosis alone or combined with other methods in China and other nations while its effective evidence is not clear. Hence, this systematic review protocol purpose is to evaluate the value of its efficacy and safety for osteoporosis. METHODS: This systematic review and meta-analysis will be performed by means of electronic databases including Cochrane Library, Medline, Cochrane Library, Web of Science, EBASE, Springer, WHO International Clinical Trials Registry Platform (ICTRP), China National Knowledge Infrastructure (CNKI), Wanfang database, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP) and others with valid search strategy probably...
February 2018: Medicine (Baltimore)
Fengwen Yang, Jiahan Zou, Long Ge, Jinhui Tian, Myeong Soo Lee, Ji Hee Jun, Junhua Zhang
BACKGROUND: Chinese herbal injections (CHIs) are commonly used for the treatment of heart failure in China. Due to the variety of CHIs used in clinic, selecting a suitable CHI for patients with heart failure is vital. This study aims to assess and compare the effect of different CHIs for heart failure using network meta-analysis (NMA). METHODS: Six electronic databases, including PubMed, the Cochrane Central Register of Controlled Trials, Embase, China National Knowledge Infrastructure, Wanfang, and Chinese Biomedical Literature Database will be search from inception to January 2018...
February 2018: Medicine (Baltimore)
Benjian Chen, Yuanping Wang, Zhuogen He, Dawei Wang, Xia Yan, Pingchang Xie
BACKGROUND: Essential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update the search and evaluation to provide the best available evidence for essential hypertension. Here, we provide a protocol to evaluate the efficacy and safety of Tianma Gouteng decoction (TGD) for essential hypertension...
February 2018: Medicine (Baltimore)
Yuanping Wang, Xiaohui Li, Ziqing Li, Yu Zhang, Dawei Wang
BACKGROUND: Chronic heart AQ4 failure (CHF) is the final stage of various heart diseases. YiQiFuMai injection (YQFMI) has been widely applied in the treatment of CHF. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails (RCTs) regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the efficacy and safety of YQFMI for CHF. METHODS: To evaluate the clinical efficacy of YQFMI in treating CHF, 2 researcher members will independently search the RCTs in the following 8 Chinese and English databases, in which the data collection will be from the time when the respective databases were established to January 2018...
February 2018: Medicine (Baltimore)
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