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Rafi Sakhi, Sing-Chien Yap, Michelle Michels, Arend F L Schinkel, R Martijn Kauling, Jolien W Roos-Hesselink, Dominic A M J Theuns
BACKGROUND: The manufacturer has developed a new ECG screening tool to determine eligibility for the subcutaneous ICD (S-ICD), the "automatic screening tool" (AST), which may render manual ECG-screening unnecessary. The aim of the study was to determine the eligibility for the S-ICD using two methods (manual ECG-screening versus AST) in different patient categories including patients with cardiomyopathy, congenital heart disease and inherited primary arrhythmia syndrome. METHODS: We prospectively evaluated the ECG suitability for an S-ICD in consecutive patients at our outpatient clinic between February and June 2017...
July 6, 2018: International Journal of Cardiology
Sergey Shlyapnikov, Arturo Jauregui, Nana N Khachatryan, Asok Kurup, Javier de la Cabada-Bauche, Hoe N Leong, Li Li, Mark H Wilcox
INTRODUCTION: Tedizolid phosphate 200 mg, once daily for 6 days, has recently been approved for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in several countries; however, clinical experience in real-life settings is currently limited. Here, we report on the use of tedizolid with an extended treatment duration for complex and severe ABSSSIs in real-world clinical settings. METHODS: Two patients with cellulitis and two patients with surgical site infection (SSI), aged 26-60 years, were treated with tedizolid phosphate 200 mg, intravenous/oral (IV/PO) or IV only, once daily at four different institutions...
July 12, 2018: Infectious Diseases and Therapy
Bernhard Wernly, Ann-Katrin Zappe, Axel Unbehaun, Jan-Malte Sinning, Christian Jung, Won-Keun Kim, Stephan Fichtlscherer, Michael Lichtenauer, Uta C Hoppe, Brunilda Alushi, Frederick Beckhoff, Charlotte Wewetzer, Marcus Franz, Daniel Kretzschmar, Eliano Navarese, Ulf Landmesser, Volkmar Falk, Alexander Lauten
OBJECTIVE: We sought to investigate the procedural and hemodynamic outcome after valve-in-valve transcatheter aortic valve replacement (VinV-TAVR) for different surgical (SBV) and transcatheter (TAVR) bioprosthetic valves. METHODS AND RESULTS: 223 patients (76 ± 11years, STS-Score 8.3 ± 10.1) suffering from SBV failure treated with VinV-TAVR were enrolled at 6 centers across Germany. At time of the intervention, the majority of patients were in NYHA-class ≥ III (88%, n = 180)...
July 12, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Mohaddeseh Ebrahimi-Ghiri, Mohammad Nasehi, Mohammad-Reza Zarrindast
The present study investigated the role of dopamine D2 receptors (D2Rs) of the dorsal hippocampus (DH) and the nucleus accumbens (NAc) and the effect of their dopaminergic activities on anxiety-like behavior and aversive learning using a test-retest elevated plus-maze (EPM) paradigm in male Wistar rats. Guide cannulae were implanted to allow microinjection of D2R agonist quinpirole or antagonist sulpiride. The pre-test intra-NAc microinjection of quinpirole (0.0625-0.25 μg/rat) or sulpiride (0.125-0.5 μg/rat) increased the percentage of time spent in the open arms (%OAT) of EPM, suggesting an anxiolytic-like effect...
July 13, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Manabu Kashiwagi, Takashi Tanimoto, Hironori Kitabata
A 74-year old man presented recurrent angina pectoris due to in-stent restenosis (ISR) with severely calcified neointima. In-stent neoatherosclerosis (NA) is associated with late stent failure, and NA with calcified neointima occurs in some cases. Because the presence of neointimal calcification could lead to underexpansion of newly implanted stent for ISR, a scoring balloon was selected for predilatation to obtain maximum extrusion of the neointimal plaque and subsequently, an everolimus-eluting stent was implanted...
2018: Case Reports in Cardiology
Celestino Sardu, Raffaele Marfella, Matteo Santamaria, Stefano Papini, Quintino Parisi, Cosimo Sacra, Daniele Colaprete, Giuseppe Paolisso, Maria R Rizzo, Michelangela Barbieri
Background: Internal cardioverter defibrillator (ICD) therapy reduced all-cause mortality. Conversely, few studies reported that ICDs' shocks may reduce survival. Recently authors suggested that, multiple inflammatory and molecular pathways were related to worse prognosis in metabolic syndrome (MS) patients treated by ICDs. Therefore, it may be relevant to find new biomarkers to predict ICDs' shock and worse prognosis in treated patients. Methods: In 99 MS vs. 107 no MS patients treated by ICD for primary prevention, we evaluated all-cause mortality, cardiac deaths, hospitalization for heart failure, appropriate and inappropriate therapy, and survival after appropriate ICD therapy...
2018: Frontiers in Physiology
Peng Liu, Jun-Xi Xiang, Xing-Long Zheng, Jing-Bo Su, Ding-Hui Dong, Li-Fei Yang, Yi Lv
OBJECTIVE: To explore the optimal implantation strategy of tissue-engineered liver (TEL) constructed based on decellularized spleen matrix (DSM) in rats. METHODS: DSM was prepared by freeze-thawing and perfusion with sodium dodecyl sulfate (SDS) of the spleen of healthy SD rats. Primary rat hepatocytes isolated using modified Seglen 2-step perfusion method were implanted into the DSM to construct the TEL. The advantages and disadvantages were evaluated of 4 transplant strategies of the TEL, namely ectopic vascular anastomosis, liver cross-section suture transplantation, intrahepatic insertion and mesenteric transplantation...
June 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Marcela Cristina Damião Andrucioli, Mírian Aiko Nakane Matsumoto, Maria Conceição Pereira Saraiva, Magda Feres, Luciene Cristina de Figueiredo, Carlos Artério Sorgi, Lucia Helena Faccioli, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Paulo Nelson-Filho
OBJECTIVES: Using two groups of mini-implants (successful and failed) the objectives of this in vivo study were: to evaluate the microbial contamination by the checkerboard DNA-DNA hybridization technique and to quantify the bacterial endotoxin by the limulus amebocyte lysate assay. MATERIAL AND METHODS: The 15 successful and 10 failed mini-implants (1.6 mm diameter × 7.0 or 9.0 mm long), placed in the maxilla and/or mandible, were obtained from 15 patients undergoing orthodontic treatment...
July 10, 2018: Journal of Applied Oral Science: Revista FOB
Amy Liao, Hobart W Harris, Michel M Maharbiz
OBJECTIVE: Ventral hernia repairs using mesh prosthetics suffer from high recurrence rates, with 10-20% of repairs failing within three years. Uneven distribution of stress within the implanted mesh prosthetic is thought to contribute to the high recurrence rate. We propose a method for providing quantitative guidance and monitoring of hernia repairs using an array of magnetoelastic strain sensors. METHODS: The magnetoelastic strain sensors presented here are based on a coupled design to achieve measurements with higher signal-to-noise ratio (SNR)...
May 8, 2018: IEEE Transactions on Bio-medical Engineering
Sanar S Yokhana, Christopher Bergum, Weiping Ren, David C Markel
Total knee prostheses are routinely redesigned to improve performance, longevity, and to closer mimic the native kinematics of the knee. Despite continued improvements, all knee implants, even those with proven design features, have failures. We identified a cohort of patients with isolated tibial component failures that occurred in a popular and successful knee system. Our purpose was to (1) characterize the observed radiographic failure pattern; (2) investigate the biologic response that may have contributed to the failure; and (3) to determine if the failure mechanism was of a biological or a mechanical nature...
July 10, 2018: Journal of Knee Surgery
Iddo Paldor, Kaisorn L Chaichana, Henry Brem, Betty M Tyler
Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers...
2018: Progress in Neurological Surgery
Sophie Putman, Florian Boureau, Julien Girard, Henri Migaud, Gilles Pasquier
Patellar complications are a source of poor total knee arthroplasty (TKA) outcomes that can require re-operation or prosthetic revision. Complications can occur with or without patellar resurfacing. The objective of this work is to answer six questions. (1) Have risk factors been identified, and can they help to prevent patellar complications? Patellar complications are associated with valgus, obesity, lateral retinacular release, and a thin patella. Selecting a prosthetic trochlea that will ensure proper patellar tracking is important...
July 7, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Junjie Hu, Yan Chen, Sijin Cheng, San Zhang, Kaiqin Wu, Wenli Wang, Yongxin Zhou
BACKGROUND: Transcatheter mitral valve-in-valve (TMVIV) and valve-in-ring (TMVIR) implantation for degenerated mitral bioprostheses and failed annuloplasty rings have recently emerged as treatment options for patients deemed unsuitable for repeat surgery. METHODS: A systematic literature review was conducted to summarize the data regarding the baseline characteristics and clinical outcomes of patients undergoing TMVIV and TMVIR procedures. RESULTS: A total of 245 patients (172 patients who underwent TMVIV surgery and 73 patients who underwent TMVIR surgery) were included in the study; 93...
July 10, 2018: Journal of Cardiac Surgery
Gabrielle Villa, Luca De Stavola, Andrea Fincato, Antonio Guida, Antonio Magliano, Mauro Merli, Giovanni Polizzi, Matthias Karl
OBJECTIVE: To evaluate the survival and complication rate of 7-mm short, parallel-walled, conical-connection implants in daily practice. METHOD AND MATERIALS: This multicenter retrospective study included 219 consecutive patients who received 323 implants. Indication was limited vertical bone height preventing placement of implants longer than 7 mm. Placement and loading protocols were determined on a case-by-case basis and included placement in fresh extraction sockets and healed sites, and loading was either immediate, early, or delayed...
July 9, 2018: Quintessence International
Sara N Shah, Jamie Chung, David M Kim, Eli E Machtei
OBJECTIVE: A randomized trial to assess clinical and radiographic outcomes of short versus standard dental implants placed with concomitant vertical bone augmentation. METHOD AND MATERIALS: Patients requiring dental implants were randomized to receive either 6-mm implants (experimental) or 10-mm implants with vertical augmentation (control). Custom load-bearing healing abutments were connected to allow for indirect resonance frequency analysis measurements. Standardized radiographs were taken at implant placement (baseline), and at 3 and 12 months...
July 9, 2018: Quintessence International
Dimitris Tsiachris, Sotiria Stabola, Athanasios Kordalis, Christodoulos Stefanadis
An injectable loop recorder was implanted in a 76-year old patient due to recurrent unexplained syncope.In the first week after implantation, asymptomatic short-term atrial fibrillation was recorded and oral anticoaguation was prescribed. Two weeks later the patient suffered a presyncope and a 5.8 seconds pause was recorded at the time of conversion of atrial fibrillation to sinus rhythm. A Micra Transcatheter Pacing System was implanted based on the minimum pacing needs. Atrial fibrillation episodes became frequent and severe symptomatic without syncope relapse...
February 2018: Journal of Atrial Fibrillation
Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
Mammalian embryogenesis requires the coordination of embryonic and extra-embryonic tissues to enable implantation into the uterus and post-implantation development to establish the body plan. Mouse embryonic stem cells (ESCs) are a useful tool for studying pluripotent embryonic tissue in vitro. However, they cannot undertake correct embryogenesis alone. Many attempts to model the early embryo in vitro involve the aggregation of ESCs into spheroids of variable size and cell number that undertake germ-layer specification but fail to recapitulate the characteristic architecture and arrangement of tissues of the early embryo...
July 9, 2018: Nature Protocols
Joseph M Legato, Megan OʼConnell, David A Fuller
PURPOSE: The purpose of this video is to demonstrate the surgical technique of a shoulder arthrodesis for a patient with multidirectional instability and multiple failed previous surgeries. METHODS: A 25-year-old woman with a long history of left shoulder multidirectional instability in the setting of Ehlers-Danlos syndrome is shown undergoing a shoulder arthrodesis. The video demonstrates intraoperative patient positioning, approach, shoulder osseous and articular preparation, implant placement (narrow 4...
August 2018: Journal of Orthopaedic Trauma
Gabriele Dell'Era, Stefano Porcellini, Enrico Boggio, Eleonora Prenna, Miriam Gravellone, Marco Varalda, Riccardo Erbetta, Veronica Lio, Eraldo Occhetta, Paolo Marino
No abstract text is available yet for this article.
July 4, 2018: Journal of Cardiovascular Medicine
Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto, Akira Orimo
Despite current advances in human colorectal cancer (CRC) treatment, few radical therapies are effective for the late stages of CRC. To overcome this clinical challenge, tumor xenograft mouse models using long-established human carcinoma cell lines and many transgenic mouse models with tumors have been developed as preclinical models. They partially mimic the features of human carcinomas, but often fail to recapitulate the key aspects of human malignancies including invasion and metastasis. Thus, alternative models that better represent the malignant progression in human CRC have long been awaited...
June 14, 2018: Journal of Visualized Experiments: JoVE
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