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https://www.readbyqxmd.com/read/30443976/a-novel-user-friendly-transcatheter-edge-to-edge-mitral-valve-repair-device-in-a-porcine-model
#1
Wenzhi Pan, Cuizhen Pan, Hasan Jilaihawi, Lai Wei, Yue Tang, Daxin Zhou, Junbo Ge
OBJECTIVES: The present study was performed to evaluate the feasibility and safety of the ValveClamp system for transcatheter edge-to-edge mitral valve repair in a porcine model. BACKGROUND: The ValveClamp system is a novel, transapically delivered edge-to-edge mitral valve repair system designed for ease of operation. METHODS: Thirteen young adult swine were enrolled in the study. The procedure was performed via the transapical approach under epicardial echocardiography guidance...
November 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30443791/a-new-classification-for-proximal-femur-bone-defects-in-conservative-hip-arthroplasty-revisions
#2
Filippo Casella, Fabio Favetti, Gabriele Panegrossi, Matteo Papalia, Francesco Falez
INTRODUCTION: In last three decades, total hip replacement in young patients became an habitual procedure. Principles of bone preservation are pushing many surgeons to implant conservative femoral components in patient younger than 65 years. Despite an overall good survivorship and clinical outcomes of conservative implants, failed cases are reported and the need to revise a conservative femoral component became an occasional procedure (with high prevalence of failed resurfacing implants)...
November 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30443302/low-serum-vitamin-d-and-early-dental-implant-failure-is-there-a-connection-a-retrospective-clinical-study-on-1740-implants-placed-in-885-patients
#3
Francesco Guido Mangano, Sina Ghertasi Oskouei, Ana Paz, Natale Mangano, Carlo Mangano
Background. Since osseointegration depends on bone metabolism, low levels of vitamin D in the blood may negatively affect bone formation around dental implants. To date, only a few studies have investigated the possible connection between serum levels of vitamin D and early dental implant failure (EDIF), i.e. failure that occurs within 4 months after placement, before the connection of the prosthetic abutment. The aim of this study was to investigate whether there is a relationship between low serum levels of vitamin D and EDIF...
2018: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/30431166/effects-of-object-to-detector-distance-and-beam-energy-on-synchrotron-radiation-phase-contrast-imaging-of-implanted-cochleae
#4
S Alireza Rohani, John E Iyaniwura, Ning Zhu, Sumit K Agrawal, Hanif M Ladak
OBJECTIVES: To demonstrate that synchrotron radiation phase-contrast imaging (SR-PCI) can be used to visualize the intrascalar structures in implanted human cochleae and to find the optimal combination of the parameters object-to-detector distance (ODD) and beam energy (E) for visualization. MATERIALS AND METHODS: Three cadaveric implanted human temporal bones underwent SR-PCI with varying combinations of parameters ODD (3, 2 and 1 m) and E (47, 60 and 72 keV). All images were then reconstructed to a three-dimensional (3D) stack of slices...
November 15, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/30429962/dental-implant-placement-in-patients-on-bisphosphonate-therapy-a-systematic-review
#5
REVIEW
Rokas Gelazius, Lukas Poskevicius, Dalius Sakavicius, Vaidas Grimuta, Gintaras Juodzbalys
Objectives: The review aims to study dental implant placement purposefulness for patients who have been treated or are on treatment with bisphosphonate medication. Material and Methods: Structured search strategy was applied on electronic databases: MEDLINE, PubMed, PubMed Central and ResearchGate. Scientific publications in English between 2006 and 2017 were identified in accordance with inclusion, exclusion criteria. Publication screening, data extraction, and quality assessment were performed...
July 2018: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/30427970/a-within-subject-comparison-of-patient-satisfaction-and-quality-of-life-between-a-two-implant-overdenture-and-a-three-implant-supported-fixed-dental-prosthesis-in-the-mandible
#6
Darryl Beresford, Iven Klineberg
PURPOSE: This within-subject comparison tested the null hypothesis that there is no difference in patient satisfaction and oral health-related quality of life when an individual with an edentulous mandible is rehabilitated with a two-implant overdenture or a three-implant-supported fixed dental prosthesis. MATERIALS AND METHODS: Twelve subjects with an edentulous mandible or failing dentition were rehabilitated with the use of endosseous dental implants. Three implants were placed, and were immediately loaded with a provisional fixed prosthesis with minimal cantilever...
November 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/30427962/survival-of-dental-implants-replacing-previously-failed-implants-a-retrospective-study-in-a-university-setting
#7
Rosalie Nguyen, Nikolaos Soldatos, Duong Tran, Popi Stylianou, Nikola Angelov, Robin Weltman
PURPOSE: The rate of dental implant failures ranges from 3% to 8%, with that number increasing as the number of implants placed increases. When an implant fails, the survival rate drops significantly when a second or third attempt is performed. The aim of this study was to evaluate the survival rate of an implant placed in a previously failed implant site and to explore the risk factors that might affect the outcome of the second procedure. MATERIALS AND METHODS: A retrospective chart review was conducted for patients receiving dental implants at the University of Texas, School of Dentistry from 1985 to 2017...
November 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/30424433/chronic-intracortical-recording-and-electrochemical-stability-of-thiol-ene-acrylate-shape-memory-polymer-electrode-arrays
#8
Allison M Stiller, Joshua Usoro, Christopher L Frewin, Vindhya R Danda, Melanie Ecker, Alexandra Joshi-Imre, Kate C Musselman, Walter Voit, Romil Modi, Joseph J Pancrazio, Bryan J Black
Current intracortical probe technology is limited in clinical implementation due to the short functional lifetime of implanted devices. Devices often fail several months to years post-implantation, likely due to the chronic immune response characterized by glial scarring and neuronal dieback. It has been demonstrated that this neuroinflammatory response is influenced by the mechanical mismatch between stiff devices and the soft brain tissue, spurring interest in the use of softer polymer materials for probe encapsulation...
September 29, 2018: Micromachines
https://www.readbyqxmd.com/read/30424376/a-meta-analysis-of-intracortical-device-stiffness-and-its-correlation-with-histological-outcomes
#9
Allison M Stiller, Bryan J Black, Christopher Kung, Aashika Ashok, Stuart F Cogan, Victor D Varner, Joseph J Pancrazio
Neural implants offer solutions for a variety of clinical issues. While commercially available devices can record neural signals for short time periods, they fail to do so chronically, partially due to the sustained tissue response around the device. Our objective was to assess the correlation between device stiffness, a function of both material modulus and cross-sectional area, and the severity of immune response. Meta-analysis data were derived from nine previously published studies which reported device material and geometric properties, as well as histological outcomes...
September 6, 2018: Micromachines
https://www.readbyqxmd.com/read/30418406/early-onset-scoliosis-is-there-an-improvement-in-quality-of-life-with-conversion-from-traditional-growing-rods-to-magnetically-controlled-growing-rods
#10
Jennifer M Bauer, Petya Yorgova, Geraldine Neiss, Kenneth Rogers, Peter F Sturm, Paul D Sponseller, Scott Luhmann, Jeff B Pawelek, Suken A Shah
BACKGROUND: Modern treatment of early onset scoliosis (EOS) includes implantation of traditional growing rods (TGR) or magnetically controlled growing rods (MCGR) for posterior-based distraction if nonoperative treatment plans failed. The recent MCGR innovation has largely been expected to improve patient and family burden by avoiding frequent return to the operating room. At least one study has shown no HRQoL difference between TGR and MCGR, but none have specifically investigated a cohort of conversion patients whose families have experienced both...
November 9, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/30412768/discovery-of-nano-piperolactam-a-a-non-steroidal-contraceptive-lead-acting-through-down-regulation-of-interleukins
#11
Plaban Bhattacharya, Achintya Saha, Souvik Basak
Elevated serum interleukins (IL-6, IL-1β) over baseline concentration help in blastocyst adhesion to the uterine endometrium in the early phase of pregnancy. A nano PLA (Piperolactam A)-HPBCD (2-hydroxy-propyl-β-cyclodextrin) inclusion complex, was developed as an interleukin down-regulator that exhibited 100% anti-implantation activity in rodents at a dose as low as 2.5-5.0mg/kg. On metabolomics study, among major glyco-lipo-protein metabolites, only serum low-density lipoprotein (LDL) or very low-density lipoprotein (VLDL) levels revealed alteration by the formulation...
November 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30412046/human-synovial-msc-good-manufacturing-practices-for-articular-cartilage-regeneration
#12
Tiago Lazzaretti Fernandes, Heitor A Kimura, Carla Cristina Gomes Pinheiro, Kazunori Shimomura, Norimasa Nakamura, José R M Ferreira, Andreas H Gomoll, Arnaldo José Hernandez, Daniela Franco Bueno
BACKGROUND: cartilage restoration is a desperately needed bridge for patients with symptomatic cartilage lesions. Chondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. Despite Autologous Chondrocyte Implantation (ACI) versatility, it still fails to fully reproduce hyaline articular cartilage characteristics. Mesenchymal stem cells (MSCs) may be isolated from various known tissues, including discarded fragments at arthroscopy such as synovial membrane...
November 9, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/30409163/impact-of-antagonistic-muscle-co-contraction-on-in-vivo-knee-contact-forces
#13
Adam Trepczynski, Ines Kutzner, Verena Schwachmeyer, Markus O Heller, Tilman Pfitzner, Georg N Duda
BACKGROUND: The onset and progression of osteoarthritis, but also the wear and loosening of the components of an artificial joint, are commonly associated with mechanical overloading of the structures. Knowledge of the mechanical forces acting at the joints, together with an understanding of the key factors that can alter them, are critical to develop effective treatments for restoring joint function. While static anatomy is usually the clinical focus, less is known about the impact of dynamic factors, such as individual muscle recruitment, on joint contact forces...
November 8, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/30406825/-leadless-endocardial-ultrasound-based-left-ventricular-stimulation-wise-crt-system-alternative-to-conventional-methods
#14
REVIEW
C Butter, S Fehrendt, V Möller, M Seifert
There are still several limitations in delivering cardiac resynchronisation therapy (CRT). After 6 months, 20-40% of patients fail to have clinical benefit due to various reasons. Endocardial stimulation rather than conventional epicardial pacing has been shown to be more physiological, improves electrical stimulation of the left ventricle (LV), has less dispersion of electrical activity and results in better resynchronisation. The WiSE™ CRT System ("Wireless stimulation endocardial system"; EBR Systems, Sunnyvale, CA, USA) provides an option for wireless, LV endocardial pacing triggered by a conventional right ventricular pacing spike from a co-implant...
November 8, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/30406273/catheter-independent-suture-probe-canaloplasty-with-suprachoroidal-drainage
#15
Arno Haus, Peter Szurman, Anna-Maria Seuthe
PURPOSE: To introduce the novel technique of suture probe canaloplasty with suprachoroidal drainage (SCD) as a catheter-independent and cost-saving method to perform non-penetrating glaucoma surgery. METHODS: Prospective interventional study with a 12-month follow-up. A standard 6/0 polypropylene suture is twisted in a special manner to create a double helix with a small loop at its end. Then canaloplasty with SCD is performed, but instead of using the standard canaloplasty catheter, Schlemm's canal is probed with the twisted suture...
November 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30406131/outcome-of-irrigation-and-debridement-after-failed-two-stage-reimplantation-for-periprosthetic-joint-infection
#16
M Faschingbauer, F Boettner, R Bieger, C Weiner, H Reichel, T Kappe
Introduction: Two-stage revision is the gold standard for the treatment of deep implant infection after knee or hip arthroplasty. Irrigation and debridement may be a treatment option for failed 2-stage revisions in cases where a reinfection occurs within 30 days or the symptoms exist not longer than 3 weeks and is appealing because of its low morbidity. We determined the incidence of recurrent infections following irrigation and debridement for failed two-stage revision hip and knee arthroplasty...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30405940/simplified-nonsurgical-treatment-of-peri-implantitis-using-chlorhexidine-and-minocycline-hydrochloride
#17
SunJin Heo, Hyun-Joo Kim, Ji-Young Joo, Juyoun Lee, Sung-Jo Kim, Jeomil Choi
Purpose: The present study investigated the outcomes of a newly-developed, simple, and practical nonsurgical treatment modality suitable for most forms of intrabony defects around failing dental implants using intrasulcular delivery of chlorhexidine solution and minocycline hydrochloride (HCl). Methods: Forty-five dental implants in 20 patients diagnosed with peri-implantitis were included. At baseline and the study endpoint, the probing pocket depth (PPD), clinical attachment level (CAL), and the presence of bleeding on probing (BOP) at 6 sites around each implant were recorded...
October 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/30402730/the-effect-of-repeated-biopsy-on-pre-implantation-genetic-testing-for-monogenic-diseases-pgt-m-treatment-outcome
#18
Shira Priner, Gheona Altarescu, Oshrat Schonberger, Hananel Holzer, Esther Rubinstein, Nava Dekel, Aharon Peretz, Talia Eldar-Geva
PURPOSE: To study the outcome of repeated biopsy for pre-implantation genetic testing in case of failed genetic diagnosis in the first biopsy. METHODS: The study group included 81 cycles where embryos underwent re-biopsy because there were no transferable embryos after the first biopsy: in 55 cycles, the first procedure was polar body biopsy (PBs) and the second cleavage-stage (BB); in 26 cycles, the first was BB and the second trophectoderm (BLAST) biopsy. The control group included 77 cycles where embryos underwent successful genetic diagnosis following the first biopsy, matched by maternal age, egg number, genetic inheritance type, and embryonic stage at the first biopsy...
November 6, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30396711/retrospective-analysis-of-porous-tantalum-trabecular-metal-enhanced-titanium-dental-implants
#19
Alexander R Edelmann, Devang Patel, Riley K Allen, Chad J Gibson, Al M Best, Sompop Bencharit
STATEMENT OF PROBLEM: The design of porous tantalum trabecular metal-enhanced titanium (TM) dental implants promises improved osseointegration, especially when grafting materials such as demineralized bone matrix are used; however, studies are lacking. PURPOSE: The purpose of this retrospective study was to compare TM implants with conventional titanium alloy (Ti) implants with and without demineralized bone matrix in terms of peri-implant bone remodeling in the first year after implant loading...
November 2, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/30391425/determinants-of-opioid-abuse-potential-insights-using-intracranial-self-stimulation
#20
REVIEW
S Stevens Negus, Megan J Moerke
Intracranial self-stimulation (ICSS) is one procedure that can be used for preclinical abuse potential assessment. In ICSS procedures, subjects with microelectrodes implanted into a brain-reward region are trained to press an operant response lever for pulses of electrical brain stimulation, and drugs are evaluated for their effectiveness to increase or "facilitate" ICSS responding (an abuse-related effect) or to depress ICSS responding (an abuse-limiting effect). ICSS has been used for decades to evaluate determinants of opioid abuse potential, and this article reviews pharmacological and biological determinants of opioid abuse potential as revealed by ICSS studies in rodents...
October 31, 2018: Peptides
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