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Vagal nerve stimulation

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https://www.readbyqxmd.com/read/29786802/-treatment-with-neurostimulation-and-ketogenic-diet-for-people-with-medically-refractory-epilepsy
#1
Eva Kumlien, Tove Hallbook, Maria Dahlin
For some people with medically refractory epilepsy adjunct treatment with neurostimulation and ketogenic diet can be an option. Vagal nerve stimulation, VNS, consists of chronic intermittent electrical stimulation of the vagus nerve. VNS is effective and well tolerated in adolescents and adults. There is insufficient evidence on the efficacy of deep brain stimulation, DBS, and brain-responsive neurostimulation, RNS. Ketogenic diet is an established treatment in epilepsy with an increased number of indications, especially in neurometabolic diseases, where dietary therapy can completely eliminate epilepsy and improve cognitive and motor development...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29767791/noninvasive-vagal-nerve-stimulation-in-chronic-migraine-with-medication-overuse-headache
#2
Alessandro Vacca, Annalisa Gai, Flora Govone, Elisa Rubino, Paola De Martino, Salvatore Gentile, Lorenzo Pinessi, Innocenzo Rainero
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29767741/gateway-reflex-neural-activation-mediated-immune-cell-gateways-in-the-central-nervous-system
#3
Daisuke Kamimura, Takuto Ohki, Yasunobu Arima, Masaaki Murakami
The neural regulation of organs can be categorized as systemic or local. Whereas systemic regulation by the hypothalamus-pituitary-adrenal gland-mediated release of steroid hormones has been well studied, the mechanisms for local regulation have only recently emerged. Two types of local neural regulation are known, the gateway reflex and the inflammatory reflex. The gateway reflex describes a mechanism that converts regional neural stimulations into inflammatory outputs by changing the state of specific blood vessels...
May 15, 2018: International Immunology
https://www.readbyqxmd.com/read/29757068/physiotherapy-interventions-for-patients-with-chronic-pelvic-pain-a-systematic-review-of-the-literature
#4
Pedro Fuentes-Márquez, Irene Cabrera-Martos, Marie Carmen Valenza
OBJECTIVE: To summarize the available scientific evidence on physiotherapy interventions in the management of chronic pelvic pain (CPP). DATA SOURCES: A systematic review of randomized controlled trials was performed. An electronic search of MEDLINE, CINAHL, and Web of Science databases was performed to identify relevant randomized trials from 2010-2016. STUDY SELECTION: Manuscripts were included if at least one of the comparison groups received a physiotherapy intervention...
May 14, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29746219/feasibility-of-continuous-intraoperative-neural-monitoring-during-transoral-endoscopic-thyroidectomy-vestibular-approach-in-a-porcine-model
#5
Daqi Zhang, Shijie Li, Gianlorenzo Dionigi, Tie Wang, Jiao Zhang, Gaofeng Xue, Hui Sun
BACKGROUND: Experimental study to evaluate feasibility of continuous intraoperative neural monitoring (C-IONM) in transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS: Duroc-Landrace pigs were orally intubated with electromyogram endotracheal tube. Automatic periodic stimulation (APS) electrode was allocated in the operative field through the 5-mm ports. APS was then repose on vagal nerve (VN) with different approaches: (1) median, that is, between sternothyroid and thyroid gland; and (2) lateral, that is, between sternocleidomastoid and sternothyroid...
May 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29744667/vagus-nerve-stimulation-exerts-cardioprotection-against-myocardial-ischemia-reperfusion-injury-predominantly-through-its-efferent-vagal-fibers
#6
Watthana Nuntaphum, Wanpitak Pongkan, Suwakon Wongjaikam, Savitree Thummasorn, Pongpan Tanajak, Juthamas Khamseekaew, Kannaporn Intachai, Siriporn C Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Vagus nerve stimulation (VNS) has been shown to exert cardioprotection against myocardial ischemia/reperfusion (I/R) injury. However, whether the cardioprotection of VNS is mainly due to direct activation through its ipsilateral efferent fibers (motor) rather than indirect effects mediated by the afferent fibers (sensory) have not been clearly understood. We hypothesized that VNS exerts cardioprotection predominantly through its efferent vagal fibers. Thirty swine (30-35 kg) were randomized into five groups: I/R no VNS (I/R), and left mid-cervical VNS with both vagal trunks intact (LC-VNS), with left vagus nerve transection (LtVNX), with right vagus nerve transection (RtVNX) and with atropine pretreatment (Atropine), respectively...
May 9, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29742457/some-technical-issues-of-vagal-nerve-stimulation-an-approach-using-a-hippocampal-formation-theta-rhythm
#7
Adam Broncel, Renata Bocian, Paulina Kłos-Wojtczak, Jan Konopacki
Previously, we have demonstrated that hippocampal (HPC) theta rhythm can be produced, depending on current intensity, directly during vagal nerve stimulation (VNS) or with a time delay following stimulation. This suggests that theta EEG pattern can also be used as a bio-indicator of the efficiency of VNS. In the present study, we focused on three specific, technical issues related to the stimulation procedure of the vagal nerve: i/does the type of the electrode used for VNS and the technique of its implantation affect the parameters of the HPC theta rhythm? ii/does the type of electrode used determine the current intensity threshold of VNS-induced HPC theta? iii/is the repeatability of the VNS effect determined by the type of electrode used? We demonstrated that a platinum-iridium cuff electrode offers some important advantages over a tungsten electrode...
May 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29740266/improvement-of-olfactory-function-with-high-frequency-non-invasive-auricular-electrostimulation-in-healthy-humans
#8
Ashim Maharjan, Eunice Wang, Mei Peng, Yusuf O Cakmak
In past literature on animal models, invasive vagal nerve stimulation using high frequencies has shown to be effective at modulating the activity of the olfactory bulb (OB). Recent advances in invasive vagal nerve stimulation in humans, despite previous findings in animal models, used low frequency stimulation and found no effect on the olfactory functioning. The present article aimed to test potential effects of non-invasive, high and low frequency vagal nerve stimulation in humans, with supplementary exploration of the orbitofrontal cortex using near-infrared spectroscopy (NIRS)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29731661/electrophysiologic-alterations-in-the-excitability-of-the-sciatic-and-vagus-nerves-during-early-stages-of-sepsis
#9
Lúcio Ricardo Leite Diniz, Viviane Gomes Portella, Kerly Shamira da Silva Alves, Pâmella Cristina da Costa Araújo, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Aline Alice Cavalcante de Albuquerque, Andrelina Noronha Coelho-de-Souza, José Henrique Leal-Cardoso
Background: Nonspecific and delayed diagnosis of neurologic damage contributes to the development of neuropathies in patients with severe sepsis. The present study assessed the electrophysiologic parameters related to the excitability and conductibility of sciatic and vagus nerves during early stages of sepsis. Materials and methods: Twenty-four hours after sepsis induced by cecal ligation and puncture (CLP) model, sciatic and vagus nerves of septic (CLP group) and control (sham group) rats were removed, and selected electric stimulations were applied to measure the parameters of the first and second components of the compound action potential...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29682044/twiddler-s-syndrome-a-rare-hardware-complication-in-spinal-cord-stimulation
#10
Byung-Chul Son, Jin-Gyu Choi, Sang-Woo Ha
Twiddler's syndrome is an uncommon hardware complication involving the lead and pulse generators in cardiac pacemakers and defibrillators, deep brain stimulators, and vagal nerve stimulators. However, until very recently, it had not been reported in spinal cord stimulation (SCS). Considering the incidence of hardware complications of spinal cord stimulation, there may be an underreporting of Twiddler's syndrome due to lack of awareness. Two cases of Twiddler's syndrome as a hardware complication of SCS were identified between 2005 and 2015...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29680919/aggravation-of-seizures-and-status-epilepticus-after-vagal-nerve-stimulation-therapy-the-first-pediatric-case-and-review-of-the-literature
#11
Ebru Arhan, Ayşe Serdaroğlu, Tuğba Hirfanoğlu, Gökhan Kurt
BACKGROUND: We describe the first child with drug-resistant epilepsy in whom vagus nerve stimulation aggravated seizures and emerged status epilepticus after the increase in vagal nerve stimulation current output. OBJECTIVE: A 13-year-old girl presented with refractory secondary generalized focal epilepsy. Vagal nerve stimulator was implanted because of drug-resistant epilepsy. After the increase of vagal nerve stimulator current output to a relatively high level, the patient experienced seizure aggravation and status epilepticus...
April 22, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29665520/treatment-resistant-depression-and-suicidality
#12
REVIEW
Isidoor O Bergfeld, Mariska Mantione, Martijn Figee, P Richard Schuurman, Anja Lok, Damiaan Denys
BACKGROUND: Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences. METHODS: We searched PubMed systematically for studies of depressed patients who failed at least two antidepressant therapies and were followed for at least three months after initiating a treatment...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29663941/using-the-oculocardiac-reflex-to-characterize-autonomic-imbalance-in-a-naturally-occurring-canine-model-of-valvular-insufficiency
#13
Bruna C Brüler, Thayane C Vieira, Marcela Wolf, Stephany B Lucina, Fabiano Montiani-Ferreira, Marlos G Sousa
Congestive heart failure (CHF) is characterized by reduced heart rate variability. Although various methods to achieve parasympathetic withdrawal and sympathetic activation have been documented, stimulation of the vagal nerve (that is, vagal maneuvers) has not often been used to assess the autonomic impairment associated with disease progression in veterinary species. In this study, we investigated cardiac autonomic control in a naturally occurring canine model of mitral insufficiency by means of individual responses to oculocardiac reflex...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663677/the-carotid-sinus-nerve-structure-function-and-clinical-implications
#14
Andrea Porzionato, Veronica Macchi, Carla Stecco, Raffaele De Caro
Interest has been renewed in the anatomy and physiology of the carotid sinus nerve (CSN) and its targets (carotid sinus and carotid body, CB), due to recent proposals of surgical procedures for a series of common pathologies, such as carotid sinus syndrome, hypertension, heart failure, and insulin resistance. The CSN originates from the glossopharyngeal nerve soon after its appearance from the jugular foramen. It shows frequent communications with the sympathetic trunk (usually at the level of the superior cervical ganglion) and the vagal nerve (main trunk, pharyngeal branches, or superior laryngeal nerve)...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29661827/oral-nahco-3-activates-a-splenic-anti-inflammatory-pathway-evidence-that-cholinergic-signals-are-transmitted-via-mesothelial-cells
#15
Sarah C Ray, Babak Baban, Matthew A Tucker, Alec J Seaton, Kyu Chul Chang, Elinor C Mannon, Jingping Sun, Bansari Patel, Katie Wilson, Jacqueline B Musall, Hiram Ocasio, Debra Irsik, Jessica A Filosa, Jennifer C Sullivan, Brendan Marshall, Ryan A Harris, Paul M O'Connor
We tested the hypothesis that oral NaHCO3 intake stimulates splenic anti-inflammatory pathways. Following oral NaHCO3 loading, macrophage polarization was shifted from predominantly M1 (inflammatory) to M2 (regulatory) phenotypes, and FOXP3+ CD4+ T-lymphocytes increased in the spleen, blood, and kidneys of rats. Similar anti-inflammatory changes in macrophage polarization were observed in the blood of human subjects following NaHCO3 ingestion. Surprisingly, we found that gentle manipulation to visualize the spleen at midline during surgical laparotomy (sham splenectomy) was sufficient to abolish the response in rats and resulted in hypertrophy/hyperplasia of the capsular mesothelial cells...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29621011/central-sleep-apnea-post-vagal-nerve-manipulation-and-stimulation-during-neck-tumor-resection-a-case-report
#16
Camila B Walters, James M Kynes, Rhonda Tucker, James Netterville
We describe a pediatric patient who underwent neck dissection for removal of a tumor and had unexpected transient central sleep apnea in the recovery room. To the best of our knowledge, this is the first report in the existing literature of central sleep apnea after surgical manipulation of the vagal nerve under anesthesia.
March 31, 2018: A&A practice
https://www.readbyqxmd.com/read/29609270/-effect-of-%C3%AE-7nachr-mediated-cholinergic-anti-inflammatory-pathway-on-inhibition-of-atrial-fibrillation-by-low-level-vagus-nerve-stimulation
#17
Y S Qian, Q Y Zhao, S J Zhang, Y J Zhang, Y C Wang, H Y Zhao, Z X Dai, Y H Tang, X Wang, T Wang, C X Huang
Objective: To investigate the effect of α7nAChR mediated cholinergic anti-inflammatory pathway on inhibition of atrial fibrillation by low-level vagus nerve stimulation(LL-VNS). Methods: Eighteen beagles were randomized into control group ( n =6), LL-VNS group ( n =6) and methyllycaconitine (MLA) + LL-VNS group ( n =6). All the beagles were subjected to rapid atrial pacing at 800 beats/min for 6 hours.And the effective refractory period (ERP) of atriums and pulmonary veins and induced atrial fibrillation (AF) were measured hourly during non-pacing...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29601305/noninvasive-neuromodulation-in-migraine-and-cluster-headache
#18
Amaal Starling
PURPOSE OF REVIEW: The purpose of this narrative review is to provide an overview of the currently available noninvasive neuromodulation devices for the treatment of migraine and cluster headache. RECENT FINDINGS: Over the last decade, several noninvasive devices have undergone development and clinical trials to evaluate efficacy and safety. Based on this body of work, single-pulse transcranial magnetic stimulation, transcutaneous supraorbital neurostimulation, and noninvasive vagal nerve stimulation devices have been cleared by the United States Food and Drug Administration and are available for clinical use for the treatment of primary headache disorders...
March 29, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29594870/treatment-strategies-for-dravet-syndrome
#19
REVIEW
Kelly G Knupp, Elaine C Wirrell
Dravet syndrome (DS) is a medically refractory epilepsy that onsets in the first year of life with prolonged seizures, often triggered by fever. Over time, patients develop other seizure types (myoclonic, atypical absences, drops), intellectual disability, crouch gait and other co-morbidities (sleep problems, autonomic dysfunction). Complete seizure control is generally not achievable with current therapies, and the goals of treatment are to balance reduction of seizure burden with adverse effects of therapies...
March 28, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29593576/vagus-nerve-as-modulator-of-the-brain-gut-axis-in-psychiatric-and-inflammatory-disorders
#20
REVIEW
Sigrid Breit, Aleksandra Kupferberg, Gerhard Rogler, Gregor Hasler
The vagus nerve represents the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate. It establishes one of the connections between the brain and the gastrointestinal tract and sends information about the state of the inner organs to the brain via afferent fibers. In this review article, we discuss various functions of the vagus nerve which make it an attractive target in treating psychiatric and gastrointestinal disorders...
2018: Frontiers in Psychiatry
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