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Vagal nerve stimulation

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https://www.readbyqxmd.com/read/29350262/vagal-nerve-stimulation-for-medically-refractory-epilepsy-in-angelman-syndrome-a-series-of-three-cases
#1
REVIEW
Krystal L Tomei, Christine Y Mau, Michael Ghali, Jayoung Pak, Ira M Goldstein
BACKGROUND: We describe three children with Angelman syndrome and medically refractory epilepsy. METHODS: Case series of three pediatric patients with Angelman syndrome and medically refractory epilepsy. All three patients failed medical treatment and were recommended for vagal nerve stimulator (VNS) implantation. RESULTS: Following VNS implantation, all three patients experienced reduction in seizure frequency greater than that afforded by medication alone...
January 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29336393/cardiac-surgery-in-a-patient-with-implanted-vagal-nerve-stimulator
#2
Aashish Jain, Dheeraj Arora, Yatin Mehta
The prevalence of epilepsy worldwide is around 0.5%-2% of the population. Antiepileptic medications are the first line of treatment in most of the cases but approximately 25%-30% epilepsy patients are refractory to the single or combination therapy. The surgical option for temporal lobe epilepsy is temporal lobectomy, which has its inherent risk of neurological deficits after the surgery. Patients who are either refractory to combination therapy or do not want surgical temporal lobectomy are the candidates for electrical stimulation therapy...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29330080/use-of-a-pulsed-radiofrequency-energy-device-peak-plasmablade%C3%A2-in-neuromodulation-implant-revisions
#3
I Ughratdar, K A Kawsar, R Mitchell, R Selway, K Ashkan
BACKGROUND: Battery replacement or revision surgery for neuromodulation implants is conventionally performed using sharp dissection. Meticulous dissection within thick scar tissue is vital to avoid damage to surrounding lead(s) which could result in more extensive revision surgery. Traditional electrosurgery devices are contraindicated as the emitted energy can be transferred to the hardware resulting in implant or tissue damage with severe consequent complications. OBJECTIVE: We report our experience and potential applications of a novel, pulsed monopolar radiofrequency energy device (PEAK PlasmaBlade™, Medtronic plc) which facilitates dissection around implants without the risk of damaging or transmitting energy through the system...
January 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29319940/medical-devices-neurological-devices-classification-of-the-external-vagal-nerve-stimulator-for-headache-final-order
#4
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the external vagal nerve stimulator for headache into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the external vagal nerve stimulator for headache's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device...
December 27, 2017: Federal Register
https://www.readbyqxmd.com/read/29315578/hcn4-pacemaker-channels-attenuate-the-parasympathetic-response-and-stabilize-the-spontaneous-firing-of-sinoatrial-node
#5
Yuko Kozasa, Noriyuki Nakashima, Masayuki Ito, Taisuke Ishikawa, Hiroki Kimoto, Kazuo Ushijima, Naomasa Makita, Makoto Takano
The heart rate is dynamically controlled by the sympathetic and parasympathetic nervous systems that regulate the sinoatrial node (SAN). HCN4 pacemaker channels are well-known causative molecule of congenital sick sinus syndrome. Although HCN4 channels are activated by cAMP, the sympathetic response of SAN was preserved in the patients carrying loss-of-function mutations of HCN4 gene. In order to clarify the contribution of HCN4 channels in the autonomic regulation of SAN, we developed novel gain-of-function mutant mice in which expression level of HCN4 channels could be reversibly changed from zero to ∼3 times of that in wild type mice, using tetracycline trans-activator and tetracycline responsive element...
January 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#6
Jonathan J Crook, Charly Brouillard, Pedro Irazoqui, Thelma Lovick
Objective Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29275193/transcutaneous-vagus-nerve-stimulation-tvns-enhances-recognition-of-emotions-in-faces-but-not-bodies
#7
Roberta Sellaro, Beatrice de Gelder, Alessandra Finisguerra, Lorenza S Colzato
The polyvagal theory suggests that the vagus nerve is the key phylogenetic substrate enabling optimal social interactions, a crucial aspect of which is emotion recognition. A previous study showed that the vagus nerve plays a causal role in mediating people's ability to recognize emotions based on images of the eye region. The aim of this study is to verify whether the previously reported causal link between vagal activity and emotion recognition can be generalized to situations in which emotions must be inferred from images of whole faces and bodies...
November 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29240833/vagal-nerve-stimulation-triggers-widespread-responses-and-alters-large-scale-functional-connectivity-in-the-rat-brain
#8
Jiayue Cao, Kun-Han Lu, Terry L Powley, Zhongming Liu
Vagus nerve stimulation (VNS) is a therapy for epilepsy and depression. However, its efficacy varies and its mechanism remains unclear. Prior studies have used functional magnetic resonance imaging (fMRI) to map brain activations with VNS in human brains, but have reported inconsistent findings. The source of inconsistency is likely attributable to the complex temporal characteristics of VNS-evoked fMRI responses that cannot be fully explained by simplified response models in the conventional model-based analysis for activation mapping...
2017: PloS One
https://www.readbyqxmd.com/read/29219123/chronic-cuffing-of-cervical-vagus-nerve-inhibits-efferent-fiber-integrity-in-rat-model
#9
Jesse Paul Somann, Gabriel Albors, Kaitlyn Neihouser, Kun-Han Lu, Zhongming Liu, Matthew Peter Ward, Abigail Durkes, J Paul Robinson, Terry Powley, Pedro Irazoqui
Numerous studies of vagal nerve stimulation (VNS) have been published showing it to be a potential treatment for chronic inflammation and other related diseases and disorders. Studies in recent years have shown that electrical stimulation of the vagal efferent fibers can artificially modulate cytokine levels and reduce systematic inflammation. Most VNS research in the treatment of inflammation have been acute studies on rodent subjects. Our study tested VNS on freely moving animals by stimulating and recording from the cervical vagus with nerve cuff electrodes over an extended period of time...
December 8, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29208957/neuronal-signals-regulate-obesity-induced-%C3%AE-cell-proliferation-by-foxm1-dependent-mechanism
#10
Junpei Yamamoto, Junta Imai, Tomohito Izumi, Hironori Takahashi, Yohei Kawana, Kei Takahashi, Shinjiro Kodama, Keizo Kaneko, Junhong Gao, Kenji Uno, Shojiro Sawada, Tomoichiro Asano, Vladimir V Kalinichenko, Etsuo A Susaki, Makoto Kanzaki, Hiroki R Ueda, Yasushi Ishigaki, Tetsuya Yamada, Hideki Katagiri
Under insulin-resistant conditions such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. A liver-brain-pancreas neuronal relay plays an important role in this process. Here, we show the molecular mechanism underlying this compensatory β-cell proliferation. We identify FoxM1 activation in islets from neuronal relay-stimulated mice. Blockade of this relay, including vagotomy, inhibits obesity-induced activation of the β-cell FoxM1 pathway and suppresses β-cell expansion. Inducible β-cell-specific FoxM1 deficiency also blocks compensatory β-cell proliferation...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29201963/valsalva-maneuver-using-a-handmade-device-in-supraventricular-tachycardia-reversion-a-quasi-experimental-study
#11
Maryam Motamedi, Mohammad Ali Akbarzadeh, Saeed Safari, Mehrnoosh Shahhoseini
Introduction: The use of vagal nerve stimulation is identified as a proper treatment option in patients with stable supraventricular tachycardia (SVT). This study aimed to assess the success of Valsalva maneuver via a handmade device in reversion of SVT. Methods: In this quasi experimental study, using a handmade device, vagus nerve stimulation was performed for SVT patients presenting to emergency department or cardiac intervention unit and the success rate and its related factors were assessed...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29197546/prevalence-of-arnold-nerve-reflex-in-adults-and-children-with-chronic-cough
#12
Peter V Dicpinigaitis, Ahmad Kantar, Oladunni Enilari, Francesco Paravati
BACKGROUND: Cough originates from stimulation of structures innervated by the vagus nerve, including the airways and distal esophagus. Arnold nerve reflex describes the induction of cough by stimulation of the external auditory canal, which is innervated by the auricular branch of the vagus. Historically, the prevalence of this reflex has been reported in the range of 2% to 3% on the basis of studies of outpatients in otolaryngology practices, but has not been investigated in healthy volunteers or in patients with chronic cough...
November 29, 2017: Chest
https://www.readbyqxmd.com/read/29180855/aural-stimulation-with-capsaicin-ointment-improved-swallowing-function-in-elderly-patients-with-dysphagia-a-randomized-placebo-controlled-double-blind-comparative-study
#13
Eiji Kondo, Osamu Jinnouchi, Seiichi Nakano, Hiroki Ohnishi, Ikuji Kawata, Hidehiko Okamoto, Noriaki Takeda
Objective: The aim of this study was to assess whether aural stimulation with ointment containing capsaicin improves swallowing function in elderly patients with dysphagia. Study design: A randomized, placebo-controlled, double-blind, comparative study. Settings: Secondary hospital. Patients and methods: Twenty elderly dysphagic patients with a history of cerebrovascular disorder or Parkinson's disease were randomly divided into two groups: 10 receiving aural stimulation with 0...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29163522/the-vagus-nerve-in-the-neuro-immune-axis-implications-in-the-pathology-of-the-gastrointestinal-tract
#14
REVIEW
Bruno Bonaz, Valérie Sinniger, Sonia Pellissier
The vagus nerve (VN) is the longest nerve of the organism and a major component of the parasympathetic nervous system which constitutes the autonomic nervous system (ANS), with the sympathetic nervous system. There is classically an equilibrium between the sympathetic and parasympathetic nervous systems which is responsible for the maintenance of homeostasis. An imbalance of the ANS is observed in various pathologic conditions. The VN, a mixed nerve with 4/5 afferent and 1/5 efferent fibers, is a key component of the neuro-immune and brain-gut axes through a bidirectional communication between the brain and the gastrointestinal (GI) tract...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163209/the-role-of-cholecystokinin-in-peripheral-taste-signaling-in-mice
#15
Ryusuke Yoshida, Misa Shin, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya
Cholecystokinin (CCK) is a gut hormone released from enteroendocrine cells. CCK functions as an anorexigenic factor by acting on CCK receptors expressed on the vagal afferent nerve and hypothalamus with a synergistic interaction between leptin. In the gut, tastants such as amino acids and bitter compounds stimulate CCK release from enteroendocrine cells via activation of taste transduction pathways. CCK is also expressed in taste buds, suggesting potential roles of CCK in taste signaling in the peripheral taste organ...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29154689/peripheral-vagal-nerve-stimulation-modulates-the-nociceptive-withdrawal-reflex-in-healthy-subjects-a-randomized-cross-over-sham-controlled-study
#16
Roberto De Icco, Daniele Martinelli, Vito Bitetto, Mauro Fresia, Eric Liebler, Giorgio Sandrini, Cristina Tassorelli
Introduction The mechanism of action of non-invasive vagal nerve stimulation in the treatment of migraine is elusive. We studied its effect in a human model of pain, the nociceptive withdrawal reflex. Methods We enrolled 10 healthy subjects who underwent active non-invasive vagal nerve stimulation and sham treatment in a randomized, cross-over, sham-controlled study. Non-invasive vagal nerve stimulation was delivered with gammaCore®. The assessment of the nociceptive withdrawal reflex was performed at baseline (T0) and at 5 (T5) and 30 (T30) minutes after stimulation...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29150643/%C3%AE-eudesmol-an-oxygenized-sesquiterpene-stimulates-appetite-via-trpa1-and-the-autonomic-nervous-system
#17
Kazuaki Ohara, Takafumi Fukuda, Yuko Ishida, Chika Takahashi, Rena Ohya, Mikio Katayama, Kunitoshi Uchida, Makoto Tominaga, Katsuya Nagai
Transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable non-selective cation channel, which is activated by various noxious or irritant substances in nature. TRPA1 activators have been generally recognized as noxious, however, foods and beverages containing TRPA1 activators are preferably consumed; the reasons for this discrepancy are not well understood. We demonstrate that TRPA1 is involved in the stimulatory appetite control mechanism. β-Eudesmol is an oxygenated sesquiterpene contained in medicinal or edible plants which activates TRPA1...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130228/-valuation-and-prospect-of-function-preserving-gastrectomy
#18
Shuchang Wang, Site Yu, Jia Xu, Gang Zhao
Preserving gastric function and improving quality of life (QOL) is the tendency of surgery for early gastric cancer. Function preserving gastrectomy (FPG) is applied to modify the extent of surgery and to achieve better quality of life at the premise of radical resection. Pylorus-preserving gastrectomy is the most favorable approach of FPG with oncological safety, which can improve nutritional status and QOL via preserving pylorus and vagal nerve. Proximal gastrectomy is widely accepted as FPG for early upper 1/3 gastric cancer...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29128975/transcutaneous-vagus-nerve-stimulation-tvns-modulates-flow-experience
#19
Lorenza S Colzato, Gina Wolters, Corinna Peifer
Flow has been defined as a pleasant psychological state that people experience when completely absorbed in an activity. Previous correlative evidence showed that the vagal tone (as indexed by heart rate variability) is a reliable marker of flow. So far, it has not yet been demonstrated that the vagus nerve plays a causal role in flow. To explore this we used transcutaneous vagus nerve stimulation (tVNS), a novel non-invasive brain stimulation technique that increases activation of the locus coeruleus (LC) and norepinephrine release...
November 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29081397/long-term-intermittent-high-amplitude-subcutaneous-nerve-stimulation-reduces-sympathetic-tone-in-ambulatory-dogs
#20
Yuan Yuan, Zhaolei Jiang, Ye Zhao, Wei-Chung Tsai, Jheel Patel, Lan S Chen, Changyu Shen, Shien-Fong Lin, Huei-Sheng Vincent Chen, Thomas H Everett, Michael C Fishbein, Zhenhui Chen, Peng-Sheng Chen
BACKGROUND: Reducing sympathetic efferent outflow from the stellate ganglia (SG) may be antiarrhythmic. OBJECTIVE: To test the hypothesis that chronic thoracic subcutaneous nerve stimulation (ScNS) could reduce SG nerve activity (SGNA) and control paroxysmal atrial tachycardia (PAT). METHODS: We performed thoracic ScNS in 8 dogs while monitoring the SGNA, vagal nerve activity (VNA) and subcutaneous nerve activity (ScNA). An additional 3 dogs were used for sham stimulation as controls...
October 25, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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