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Huang Guo-Dong, Ji Tao, Yang Ji-Hu, Zheng Wen-Jian, Zhang Xie-Jun, Guo Jian, Li Zhen, Jiang Tai-Peng, Ding Jian-Jun, Gao Yong-Zhong, Liu Wenlan, Li Wei-Ping
BACKGROUND: To compare the clinical outcomes and complications of 247 pituitary tumor patients managed by endoscopic and microscopic approaches in our hospital. METHODS: The authors performed a retrospective review of 100 pituitary tumor patients treated by endoscopic endonasal transsphenoidal surgery (ETS) and 147 patients treated by microscopic transsphenoidal surgery (MTS) at our center from January 2007 to July 2014. The tumors were stratified by Knosp classification and modified Hardy classification, and tumor gross total resection (GTR)/remission rate, visual improvement rate, complications, operation time, intraoperative bleeding and length of hospital stay were compared between ETS and MTS...
October 2016: Journal of Craniofacial Surgery
Hui Zhang, Li Ma, Yu-Bo Wang, Cheng Shu, Yong-An Huang, Lian-Qiang Dong, Gang-Ge Cheng
OBJECTIVE: Clear cell meningioma (CCM) is a rare histological subtype of meningioma which is classified as WHO grade II tumor. We conducted the present study to characterize clinical features of intracranial CCM and investigate the prognostic factors associated with surgical recurrence-free survival (RFS) of the patients. METHODS: PubMed and Embase were searched for case reports and series relevant to CCM. For each included study, relevant data were extracted, including patients' characteristics, pathology findings, therapeutic modality, and outcome...
October 12, 2016: World Neurosurgery
Eleni Papachristou, Aikaterini Tsagkovits, Assimina Zavitsanou, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: Most of the HCV transmission the recent years in Greece was among IDUs. Our aim was to estimate the prevalence of HCV genotypes and to investigate the patterns of HCV dispersal among IDUs in Athens using current state of the art molecular epidemiology methods. METHODS: HCV sequences were determined from 238 HIV-negative IDUs collected on the basis of the "ARISTOTLE" prevention program carried out in Athens between 2012 and 2013. Phylogenetic trees were inferred on HCV sequences isolated from IDUs in Athens for the most prevalent HCV clades (subtypes 1a and 3a)...
October 6, 2016: Infection, Genetics and Evolution
Justin A Neira, Timothy H Ung, Jennifer S Sims, Hani R Malone, Daniel S Chow, Jorge L Samanamud, George J Zanazzi, Xiaotao Guo, Stephen G Bowden, Binsheng Zhao, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Peter Canoll, Randy S D'Amico, Jeffrey N Bruce
OBJECTIVE Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma (GBM). Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue, facilitating safe maximal resection of GBM. In this study, the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing (CE) regions, where this relationship has been established, and into the non-CE (NCE), diffusely infiltrated margins...
October 7, 2016: Journal of Neurosurgery
Deyang Xu, Franziska S Hanschen, Katja Witzel, Sebastian J Nintemann, Hussam Hassan Nour-Eldin, Monika Schreiner, Barbara Ann Halkier
Casparian strip-generated apoplastic barriers not only control the radial flow of both water and ions but may also constitute a hindrance for the rhizosecretion of stele-synthesized phytochemicals. Here, we establish root-synthesized glucosinolates (GLS) are in Arabidopsis as a model to study the transport routes of plant-derived metabolites from the site of synthesis to the rhizosphere. Analysing the expression of GLS synthetic genes in the root indicate that the stele is the major site for the synthesis of aliphatic GLS, whereas indole GLS can be synthesized in both the stele and the cortex...
October 4, 2016: Journal of Experimental Botany
M Zhi, M R Girvigian, M J Miller, J C Chen, J Rahimian, K Lodin
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Lingcheng Zeng, Yan Wang, Yu Wang, Lin Han, Hongquan Niu, Mengxian Zhang, Changshu Ke, Jian Chen, Ting Lei
Increasing evidence has suggested a close relationship between solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) in the central nervous system (CNS). However, CNS SFTs differentiate from HPCs in their clinical behavior and patient prognoses. Analyses of prognosis-related factors can help clarify the relationship between SFT and HPC. The intracranial SFT and HPC cases treated in our departments from January 2002 to December 2012 were retrospectively reviewed. The SFT and HPC cases were also combined into an SFT/HPC group...
September 26, 2016: Journal of Neuro-oncology
Tadanori Tomita, Jerome M Volk, Wenjun Shen, Tatiana Pundy
OBJECT: Glioneuronal tumors are common neoplasms among the cerebral hemisphere during childhood. They consist of several histological types, of which gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumors (DNTs) are most common and often present with seizures. A great majority of glioneuronal tumors are benign. However, there are conflict reports regarding postoperative tumor recurrence rates and seizure control. The authors analyzed and compared these tumors for their locations and histology and the tumor and seizure control following resection...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Anas Abdallah, Murad Asilturk, Mustafa Levent Uysal, Erhan Emel, Betül Guler Abdallah, Bilge Bilgic, Gokcen Gundogdu
AIM: Primary intracranial germinomas (PIGs) are rare malignant brain tumors that represent approximately 0.2% to 1.7% of all primary intracranial tumors. PIGs have infrequent, but existent possibility of spinal cord metastases. In this study, clinical outcomes of five consecutive PIGs have been presented. MATERIAL AND METHODS: Medical records were retrospectively reviewed in 1,849 cases of intracranial tumors whom underwent surgery between the years 2005 and 2015, cases which confirmed as germinoma histopathologically were included in this study...
August 23, 2016: Turkish Neurosurgery
Nathan V Whelan, Kenneth M Halanych
As phylogenetic datasets have increased in size, site-heterogeneous substitution models such as CAT-F81 and CAT-GTR have been advocated in favor of other models because they purportedly suppress long-branch attraction (LBA). These models are two of the most commonly used models in phylogenomics, and they have been applied to a variety of taxa ranging from Drosophila to land plants. However, many arguments in favor of CAT models have been based on tenuous assumptions about the true phylogeny rather than rigorous testing with known trees via simulation...
September 14, 2016: Systematic Biology
Burçak Bilginer, Şahin Hanalioğlu, Cezmi Çağrı Türk, Fırat Narin, Kader Karlı Oğuz, Figen Söylemezoğlu, Nejat Akalan
AIM: Pediatric glioblastoma is still a topic obscurities. This study was to explore clinical, radiological and pathological features, and prognostic factors affecting the outcomes. MATERIAL AND METHODS: We retrospectively reviewed our database for prognostic factors for 42 consecutive pediatric patients with histologically proven GBM treated in our hospital. RESULTS: The study reached at 20 boys and 22 girls, with a mean age of 10.2 years...
September 21, 2015: Turkish Neurosurgery
Luxin Yin, Chunde Li, Shiqi Luo, Zhenyu Ma
AIM: To study the clinical features, imaging findings, treatment methods and results, and prognosis of supratentorial parenchymal ependymomas of children. MATERIAL AND METHODS: Fourteen children with supratentorial parenchymal ependymomas were treated by the senior author at Tiantan Hospital between October 2004 and May 2010. The clinical manifestations, neuroimaging findings, treatment methods, and therapeutic results were retrospectively reviewed. RESULTS: The study included 11 boys and three girls...
September 21, 2015: Turkish Neurosurgery
Sivashanmugam Dhandapani, Harminder Singh, Hazem M Negm, Salomon Cohen, Vijay K Anand, Theodore H Schwartz
BACKGROUND: Despite the substantial impact of cavernous sinus invasion(CSI) in pituitary adenoma surgery, its radiological determination has been inconsistent and variable, with unclear role of endonasal endoscopic surgery. This is a systematic review and pooled data meta-analysis of literature to ascertain the best radiological criteria for CSI, and verify the efficacy and safety of endonasal endoscopic approach. METHODS: We searched MEDLINE database(1993-2015) to identify studies on radiological criteria for CSI, and endonasal surgery...
August 30, 2016: World Neurosurgery
Xinshan Hou, Jingwen Yuan, Absijiang Aisaiti, Yuan Liu, Jin Zhao
BACKGROUND: Studies investigating the use of platelet-rich plasma (PRP) in the treatment of intrabony defects have yielded mixed results. The aim of our study was to evaluate the efficacy of PRP by comparing clinical attachment level (CAL) and pocket depth (PD) for patients who received PRP as an adjunct to periodontal intrabony defect therapy with those for patients who did not. We also analyzed the influence of guided tissue regeneration (GTR) and different study designs (parallel and split-mouth studies) on the clinical outcomes of intrabony defects...
2016: BMC Oral Health
Zeeshan Sheikh, Abdul Samad Khan, Nima Roohpour, Michael Glogauer, Ihtesham U Rehman
Periodontal disease if left untreated can result in creation of defects within the alveolar ridge. Barrier membranes are frequently used with or without bone replacement graft materials for achieving periodontal guided tissue regeneration (GTR). Surface properties of barrier membranes play a vital role in their functionality and clinical success. In this study polyetherurethane (PEU) membranes were synthesized by using 4,4'-methylene-diphenyl diisocyanate (MDI), polytetramethylene oxide (PTMO) and 1,4-butane diol (BDO) as a chain extender via solution polymerization...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Brian R Hirshman, Laurie A Jones, Kate T Carroll, Jessica A Tang, James A Proudfoot, Kathleen M Carley, Bob S Carter, Clark C Chen
BACKGROUND: The paradigm of evidence-based medicine dictates that clinical practice should reflect the shifting landscape of the peer-reviewed literature. Here, we examine the extent to which this premise is fulfilled as it pertains to the surgical resection of high-grade gliomas (HGGs). OBJECTIVE: We assess trends in published literature regarding HGG survival after resection in conjunction with clinical practice patterns of HGG resection. METHODS: We performed a comprehensive PubMed search to identify articles that examined whether gross total resection (GTR) improves HGG survival...
August 11, 2016: World Neurosurgery
Xinbo Ge, Zhen Wu, Junting Zhang, Liwei Zhang
AIM: To study the surgical strategies and functional outcomes of intramedullary cervicomedullary ependymoma (ICE). MATERIAL AND METHODS: The authors retrospectively reviewed the clinical and imaging data of ICE 28 patients who underwent surgical resection, including 11 males and 17 females and the average age was 37.9 years (range: 11-69 years). Modified McCormick grading system (mMG) was used to evaluate the neurological functions before surgery, at discharge and at long-term follow-up...
April 13, 2016: Turkish Neurosurgery
M Sam Eljamel, Syed Osama Mahboob
BACKGROUND: Surgical resection of high-grade gliomas (HGG) is standard therapy because it imparts significant progression free (PFS) and overall survival (OS). However, HGG-tumor margins are indistinguishable from normal brain during surgery. Hence intraoperative technology such as fluorescence (ALA, fluorescein) and intraoperative ultrasound (IoUS) and MRI (IoMRI) has been deployed. This study compares the effectiveness and cost-effectiveness of these technologies. METHODS: Critical literature review and meta-analyses, using MEDLINE/PubMed service...
August 1, 2016: Photodiagnosis and Photodynamic Therapy
Nicola Montano, Fabio Papacci, Gianluca Trevisi, Eduardo Fernandez
Recently, great advances have been made in the surgical treatment of intramedullary spinal cord tumors (IMSCTs). Many articles have been published; but looking at the literature of the last 5 years, there are only descriptive reviews and no works in which a literature statistical analysis was performed. Here, we analyzed the literature to identify potential prognosticators of good functional outcome in IMSCT patients. To level out the selected studies, we stratified patients' neurological status as independent (ambulation possible without caregiver assistance) or disabled (cannot ambulate or can only ambulate with caregiver assistance)...
July 30, 2016: Acta Neurologica Belgica
Bor-Shiunn Lee, Chien-Chen Lee, Hung-Pin Lin, Wei-An Shih, Wan-Ling Hsieh, Chern-Hsiung Lai, Yasuo Takeuchi, Yi-Wen Chen
Currently used guided tissue regeneration (GTR) membranes are mainly used as a barrier to prevent epithelial cells growth into defects before new bone formation. The aim of this study was to develop a tri-layer functional chitosan (CS) membrane with epigallocatechin-3-gallate (EGCG) grafted on the outer layer for bactericidal activity, and lovastatin was included in the middle layer for controlled release. Successful EGCG grafting was demonstrated using Fourier transform infrared spectroscopy and EGCG grafting significantly enhanced adhesion and proliferation of human gingival fibroblasts...
October 20, 2016: Carbohydrate Polymers
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