Read by QxMD icon Read


Olabisi R Sanusi, Omar Arnaout, Rudy J Rahme, Craig Horbinski, James P Chandler
OBJECTIVE: Chordomas are rare tumors of notochordal origin that are known to be locally aggressive and are often treated with surgical resection followed by adjuvant radiotherapy. The accepted standard of treatment for chordomas of the mobile spine which includes en-bloc resection with wide margins cannot be easily applied to the chordomas of the skull base given their proximity to critical neurovascular structures. We describe our experience with the role of surgery and adjuvant radiation in the treatment of chordomas over 16 years...
March 12, 2018: World Neurosurgery
Jordan Perry, Wayne Johnson, Gilbert W Fellingham, Pat R Vehrs
Background/Objective: The heart rate (HR) and metabolic (VO2 ) responses to treadmill running using the GlideTrak™ body weight support system have not been reported. The purpose of this study was to compare the submaximal and maximal HR and VO2 responses to normal-weight treadmill running (TMR) to treadmill running with body weight support provided by the GlideTrak™ (GTR). Methods: Twenty participants (11 males; 9 females) 18 to 26 years of age voluntarily participated in this study...
June 2017: Journal of Exercise Science and Fitness
Yang Ji-Hu, Huang Guo-Dong, Ji Tao, Wang Hai-Dong, Liu Yu-Fei, Guo Jian, Li Zhen, Li Wei-Ping
OBJECTIVE: To explore the surgical methods and clinical effect of endoscopic endonasal approaches for the treatment of invasive pituitary adenomas(IPA). METHODS: A retrospective analysis of the clinical data of 74 patients(75 procedures) with invasive pituitary adenomas treated by different endoscopic endonasal approaches at the Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University from May 2014 to August 2017. The data include clinical manifestation, imaging features, surgical methods and complications, resection rate, cure rate, prognosis and complications in different Knosp classifications and Hardy stages...
March 7, 2018: World Neurosurgery
Yantao Wu, Li Li, Guoqiang Zhu, Wenhui Li, Nianzhang Zhang, Shuangnan Li, Gang Yao, Wenjun Tian, Baoquan Fu, Hong Yin, Xingquan Zhu, Hongbin Yan, Wanzhong Jia
BACKGROUND: Cervids used to be considered the only animal intermediate hosts of the G10 genotype of Echinococcus canadensis. Yaks are often herded in the Qinghai-Tibet Plateau, China, where echinococcosis remains prevalent. However, no E. canadensis G10 cases have been recorded in yaks until now. The aim of our study was to identify causative agents of echinococcosis in yaks in this region. METHODS: Total genomic DNA was extracted from the germinal layer of one hydatid using a Blood and Tissue Kit...
March 9, 2018: Parasites & Vectors
Maria Wostrack, Florian Ringel, Sven O Eicker, Max Jägersberg, Karl Schaller, Johannes Kerschbaumer, Claudius Thomé, Ehab Shiban, Michael Stoffel, Benjamin Friedrich, Victoria Kehl, Peter Vajkoczy, Bernhard Meyer, Julia Onken
OBJECTIVE Spinal ependymomas are rare glial neoplasms. Because their incidence is low, only a few larger studies have investigated this condition. There are no clear data concerning prognosis and therapy. The aim of the study was to describe the natural history, perioperative clinical course, and local tumor control of adult patients with spinal ependymomas who were surgically treated under modern treatment standards. METHODS The authors performed a multicenter retrospective study. They identified 158 adult patients with spinal ependymomas who had received surgical treatment between January 2006 and June 2013...
March 9, 2018: Journal of Neurosurgery. Spine
Lobat Tayebi, Morteza Rasoulianboroujeni, Keyvan Moharamzadeh, Thafar K D Almela, Zhanfeng Cui, Hua Ye
Three-dimensional (3D) printing is currently being intensely studied for a diverse set of applications, including the development of bioengineered tissues, as well as the production of functional biomedical materials and devices for dental and orthopedic applications. The aim of this study was to develop and characterize a 3D-printed hybrid construct that can be potentially suitable for guided tissue regeneration (GTR). For this purpose, the rheology analyses have been performed on different bioinks and a specific solution comprising 8% gelatin, 2% elastin and 0...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Lucas Hidalgo Pitaluga, Marina Trevelin Souza, Edgar Dutra Zanotto, Martin Eduardo Santocildes Romero, Paul V Hatton
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively...
March 8, 2018: Materials
Fuyou Guo, Guoqing Wang, Vigneyshwar Suresh, Dingkang Xu, Xiaoyang Zhang, Mengzhao Feng, Fang Wang, Xianzhi Liu, Laijun Song
OBJECTIVES: The optimal management of craniopharyngioma is still controversial. The aim of this study is to explore microsurgical outcomes of craniopharyngioma in 335 cases. PATIENTS AND METHODS: Clinical data of 335 consecutive patients with craniopharyngioma between March 2011 and March 2017 were retrospectively analyzed. RESULTS: Gross total resection (GTR) was achieved in 265 cases (79.1%), subtotal resection (STR) was obtained in 70 cases (20...
February 28, 2018: Clinical Neurology and Neurosurgery
Georges Sinclair, Yehya Al-Saffar, Marina Brigui, Heather Martin, Jessica Bystam, Hamza Benmakhlouf, Alia Shamikh, Ernest Dodoo
Background: Although widely regarded as rare epithelial tumors with a low grade of malignancy, endolymphatic sac tumors (ELST) often lead to disabling petrous bone destruction and significantly impairing symptoms at the time of primary diagnosis and/or recurrence. ELST is not uncommon in von Hippel Lindau (VHL) patients. Although open surgery is regarded as the best treatment option, recurrence remains a challenge, particularly when gross tumor resection (GTR) is deemed unachievable due to topographic conditions...
2018: Surgical Neurology International
Murat Kutlay, Abdullah Durmaz, İlker Özer, Cahit Kural, Çağlar Temiz, Serdar Kaya, İlker Solmaz, Mehmet Daneyemez, Yusuf Izci
OBJECTIVE: With the use of multiple endoscopic endonasal surgical corridors, extended endoscopic endonasal approaches (EEEAs) are now being used to treat a wide range of ventral skull base lesions. Our aim was to present our experience with EEEAs to the ventral skull base lesions. PATIENTS AND METHODS: The study group consisted of 106 patients (57 men and 49 women) who underwent surgery for skull base lesions using EEEAs from 2010 to 2017. The EEEA was most commonly used for giant pituitary macroadenomas, sinonasal malignancies, cerebrospinal fluid (CSF) leaks, meningiomas, craniopharyngiomas, and fibro-osseous lesions...
February 21, 2018: Clinical Neurology and Neurosurgery
Jared F Sweeney, Heather Smith, AmiLyn Taplin, Eric Perloff, Matthew A Adamo
OBJECTIVE Intraoperative ultrasonography (IOUS) is a widely accessible imaging modality that provides real-time surgical guidance with minimal identified risk or additional operative time. A recent study by the authors found a strong correlation between IOUS and postoperative MRI findings when evaluating the extent of tumor resection, suggesting that IOUS might have significant clinical implications. The objective of this study was to expand on results from the previous study in order to provide more evidence on the usage of IOUS in the determination of gross-total resection (GTR) in both adult and pediatric patients with brain tumors...
February 16, 2018: Journal of Neurosurgery. Pediatrics
Liang Lv, Yu Hu, Peizhi Zhou, Shizhen Zhang, Senlin Yin, Nannan Zhang, Shu Jiang
OBJECTIVE: Acromegalic patients with macro- or giant adenomas often had poor prognosis after surgery. Somatostatin analogues (SSAs) show high effectiveness in both tumor shrinkage and serum GH reduction. But the role of SSAs in pre-surgical treatment and the management among macro- and giant adenomas remains controversial. PATIENTS AND METHODS: A total of 100 acromegalic patients with macro- or giant adenomas that underwent surgery in our institution between January 2010 and December 2016 were enrolled in the current retrospective study...
February 6, 2018: Clinical Neurology and Neurosurgery
Takako Kawasaki, Seigo Ohba, Yuya Nakatani, Izumi Asahina
The guided bone regeneration (GBR) technique is often applied to provide sufficient bone for ideal implant placement. The objective of this study was to evaluate whether GC membrane®, which has already been used for guided tissue regeneration (GTR), can also be available for GBR. Twenty-three implants in 18 patients were evaluated in the study. All patients underwent implant placement with GBR using GC membrane®. Cone-beam computed tomography was performed at 13-30 weeks after surgery and the amount of augmented bone was assessed...
February 10, 2018: Odontology
Connor J Kinslow, Samuel S Bruce, Ali I Rae, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Jeffrey N Bruce, Adam M Sonabend, Tony J C Wang
The World Health Organization (WHO) classification of tumors of the central nervous system (CNS) was recently updated, restructuring solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) into one combined entity. This is the first population-based study to examine outcomes of SFT/HPC based on the new WHO guidelines. The Surveillance, Epidemiology, and End Results (SEER) database (1998-2013) was queried to examine age-adjusted incidence and prognostic factors associated with overall survival in 416 surgically resected cases...
February 9, 2018: Journal of Neuro-oncology
Andrej Pala, Anne Lea Schmitz, Andreas Knoll, Max Schneider, Michal Hlavac, Ralph König, Christian Rainer Wirtz, Jan Coburger
OBJECTIVES: At present, there is no standard therapy approved for recurrent glioblastoma (rGB). In particular, the counselling of patients with an unmethylated O 6 -methylguanine-DNA methyltransferase (MGMT) promoter GB remains a challenge. Our aim was to compare the overall survival (OS) and progression free survival (PFS) in patients treated surgically and non-surgically at the time of GB recurrence. This was evaluated with particular reference to the impact of recurrent surgery for patients with unmethylated MGMT promoter rGB...
February 5, 2018: Clinical Neurology and Neurosurgery
Karolina Nemes, Nathalie Clément, Denis Kachanov, Susanne Bens, Martin Hasselblatt, Beate Timmermann, Reinhard Schneppenheim, Joachim Gerss, Reiner Siebert, Rhoikos Furtwängler, Franck Bourdeaut, Michael Christoph Frühwald
BACKGROUND: Congenital rhabdoid tumors are rare and highly aggressive malignancies. In general, patients are considered to be incurable and are often treated using an exclusive, primarily palliative approach. METHODS: A prospective and retrospective collection of 42 patients from the European Rhabdoid Registry (EU-RHAB), France and Moscow (2006-2016) diagnosed within the first 28 days of life was evaluated. Genetic and clinical reference evaluation included SMARCB1 and/or SMARCA4 (fluorescence-in-situ-hybridization, multiplex ligation-dependent probe amplification, and sequencing) mutation analysis and immunohistochemistry...
February 8, 2018: Pediatric Blood & Cancer
Hamideh Akbari, Mojtaba Malek, Mohammad Ghorbani, Seyed Mahmoud Ramak Hashemi, Mohammad Ebrahim Khamseh, Ali Zare Mehrjardi, Zahra Emami, Ameneh Ebrahim Valojerdi
OBJECTIVE: To compare clinical outcomes of large pituitary adenomas (≥3 cm in maximum diameter), operated on by Endoscopic Transsphenoidal Surgery (ETS), versus Microscopic Transsphenoidal Surgery (MTS). METHODS: Medical records and MRI Scans of patients with a diagnosis of pituitary adenoma for whom transphenoidal surgery was done were reviewed. Complete pre and post-operative data were available for 121 patients. Thirty five patients had large pituitary adenoma and were enrolled in this study...
February 8, 2018: British Journal of Neurosurgery
Jing Wu, Natalie Neale, Yuqian Huang, Harrison X Bai, Xuejun Li, Zishu Zhang, Giorgos Karakousis, Raymond Huang, Paul J Zhang, Lei Tang, Bo Xiao, Li Yang
BACKGROUND: It is becoming increasingly common to incorporate chemotherapy (CT) with radiotherapy (RT) in the treatment of low-grade gliomas (LGGs) after surgical resection. However, there is a lack of literature comparing survival of patients who underwent RT or CT alone. METHODS: The U.S. National Cancer Data Base was used to identify patients with histologically confirmed, World Health Organization grade 2 gliomas who received either RT alone or CT alone after surgery from 2004 to 2013...
January 31, 2018: World Neurosurgery
Mengmeng Wang, Rende Zhang, Xueyou Liu, Dongming Li, Peichao Zhao, Yuchao Zuo, Peng Zhang, Junkuan Wang, Hongwei Sun
OBJECTIVE: Cortical ependymomas (CEs), supratentorial ependymoma that selectively involve the cerebral cortex, is relatively rare neoplasm which have not been extensively described. The purpose of our study was to identify the clinical features, radiologic characteristics, and treatment of a series of such tumors. METHODS: Thirteen patients with cortical ependymomas from our hospital were included in this study. Epidemiological characteristics, clinical features, imaging findings, treatment methods and clinical outcomes were reviewed retrospectively...
January 30, 2018: World Neurosurgery
Masahide Matsuda, Hidehiro Kohzuki, Eiichi Ishikawa, Tetsuya Yamamoto, Hiroyoshi Akutsu, Shingo Takano, Masashi Mizumoto, Koji Tsuboi, Akira Matsumura
Despite cumulative evidence supporting the idea that gross total resection (GTR) contributes to prolonged survival of patients with glioblastoma (GBM), the survival outcome of such patients remains unsatisfactory. To develop more effective postoperative therapeutic strategies for patients who underwent GTR, identification of prognostic factors influencing survival is urgently needed. Here we retrospectively analyzed prognostic factors for patients who underwent GTR of newly diagnosed GBM, with a particular focus on the influence of the subventricular zone (SVZ) as the tumor location...
January 22, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"