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https://www.readbyqxmd.com/read/28091817/teratomas-of-the-cranial-vault-a-systematic-analysis-of-clinical-outcomes-stratified-by-histopathological-subtypes
#1
Carlito Lagman, Timothy T Bui, Brittany L Voth, Lawrance K Chung, David J Seo, Courtney Duong, Mark R Libowitz, Naomi E Walker, Daniel T Nagasawa, Isaac Yang
BACKGROUND: Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses: mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas. METHODS: We performed a systematic analysis of the published literature to identify studies describing patients with intracranial teratomas diagnosed with magnetic resonance imaging (MRI) and presenting definite information on histologies, therapies, and outcomes at a minimum follow-up of 2 years...
January 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28090798/switching-from-branded-to-generic-glatiramer-acetate-15-month-gate-trial-extension-results
#2
Krzysztof Selmaj, Frederik Barkhof, Anna N Belova, Christian Wolf, Evelyn Rw van den Tweel, Janine Jl Oberyé, Roel Mulder, David F Egging, Norbert P Koper, Jeffrey A Cohen
BACKGROUND: Open-label 15-month follow-up of the double-blind, placebo-controlled Glatiramer Acetate clinical Trial to assess Equivalence with Copaxone(®) (GATE) trial. OBJECTIVE: To evaluate efficacy, safety, and tolerability of prolonged generic glatiramer acetate (GTR) treatment and to evaluate efficacy, safety, and tolerability of switching from brand glatiramer acetate (GA) to GTR treatment. METHODS: A total of 729 patients received GTR 20 mg/mL daily...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28034354/recombinant-activated-factor-vii-eptacog-alfa-activated-novoseven-%C3%A2-in-patients-with-rare-congenital-bleeding-disorders-a-systematic-review-on-its-use-in-surgical-procedures
#3
Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Veronika A Myasoedova, Manuela Amato, Itala Ventre, Elena Tremoli, Alessandro Di Minno
In the absence of definite guidelines in the area, we have carried a systemic review to provide a thorough overview concerning the efficacy and safety of recombinant activated factor VII (rFVIIa, NovoSeven®, Novo Nordisk A/S, Bagsværd, Denmark) in patients with Glanzmann's thrombasthenia (GT) and FVII deficiency, undergoing surgical procedures. PubMed, Web of Science, Scopus and EMBASE databases was employed for the search. Three multicenter registries were identified: the Glanzmann's Thrombasthenia Registry (GTR), the Seven Treatment Evaluation Registry (STER), and a German post-marketing surveillance registry (the WIRK study)...
December 30, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28019107/gross-total-resection-rates-of-grade-ii-iii-intramedullary-ependymomas-using-the-surgical-strategy-of-en-bloc-resection-without-intra-operative-neurophysiological-monitoring
#4
Kieron J Sweeney, Matt Reynolds, Michael Farrell, Ciaran Bolger
INTRODUCTION: Grade II and III intramedullary ependymomas [IME] are circumscribed with a plane of cleavage that should facilitate high gross total resection rates (GTR). Gross total resection of grade II/III IME is superior to subtotal resection (STR) and radiotherapy (RTx) for progression-free and overall survival. We sought to compare our GTR with other series that have utilised standard intraoperative monitoring techniques and we explored factors that may influence rates of resection...
December 25, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28017751/solitary-fibrous-tumor-of-the-central-nervous-system-a-clinical-and-prognostic-study-of-24-cases
#5
Nian Jiang, Yuan-Yang Xie, Wen Chen, Ze-Feng Peng, Xian-Rui Yuan, Xue-Jun Li, Cheng-Yuan Feng, Si-Yi Wang-Gou
BACKGROUND: Solitary fibrous tumors(SFT) are rare mesenchymal tumors that occasionally occur in the central nervous system(CNS). It is difficult to fully understand their clinical characteristics, partly due to a limited number of reported cases. METHODS: We reviewed 24 patients admitted to our institution between 2009 and 2016 with CNS solitary fibrous tumors. We reviewed and analyzed patient profiles, such as demographics, presentations, imaging studies, extent of resection, and adjuvant treatment...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28008945/using-nearly-full-genome-hiv-sequence-data-improves-phylogeny-reconstruction-in-a-simulated-epidemic
#6
Gonzalo Yebra, Emma B Hodcroft, Manon L Ragonnet-Cronin, Deenan Pillay, Andrew J Leigh Brown
HIV molecular epidemiology studies analyse viral pol gene sequences due to their availability, but whole genome sequencing allows to use other genes. We aimed to determine what gene(s) provide(s) the best approximation to the real phylogeny by analysing a simulated epidemic (created as part of the PANGEA_HIV project) with a known transmission tree. We sub-sampled a simulated dataset of 4662 sequences into different combinations of genes (gag-pol-env, gag-pol, gag, pol, env and partial pol) and sampling depths (100%, 60%, 20% and 5%), generating 100 replicates for each case...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28005261/results-of-a-multicenter-survey-showing-interindividual-variability-among-neurosurgeons-when-deciding-on-the-radicality-of-surgical-resection-in-glioblastoma-highlight-the-need-for-more-objective-guidelines
#7
J Capellades, P Teixidor, G Villalba, C Hostalot, G Plans, R Armengol, S Medrano, A Estival, R Luque, S Gonzalez, M Gil-Gil, S Villa, J Sepulveda, J J García-Mosquera, C Balana
PURPOSE: We assessed agreement among neurosurgeons on surgical approaches to individual glioblastoma patients and between their approach and those recommended by the topographical staging system described by Shinoda. METHODS: Five neurosurgeons were provided with pre-surgical MRIs of 76 patients. They selected the surgical approach [biopsy, partial resection, or gross total resection (GTR)] that they would recommend for each patient. They were blinded to each other's response and they were told that patients were younger than 50 years old and without symptoms...
December 22, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27965900/treatment-of-a-developmental-groove-and-supernumerary-root-using-guided-tissue-regeneration-technique
#8
Zahra Alizadeh Tabari, Hamed Homayouni, Tahere Pourseyediyan, Armita Arvin, Derrick Eiland, Nima Moradi Majd
Introduction. The radicular groove is a developmental groove which is usually found on the palatal or lateral aspects of the maxillary incisor teeth. The present case is a maxillary lateral incisor with a small second root and a deep radicular groove. The developmental groove caused a combined periodontal-endodontic lesion. Methods. Case was managed using a combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal treatment. After completion of root canal treatment, guided tissue regeneration (GTR) was carried out using decalcified freeze dried bone allograft (DFDBA) and a bioabsorbable collagenous membrane...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27939796/the-feasibility-analysis-for-treatment-of-infancy-giant-intracranial-benign-tumor-by-delayed-operation
#9
Wanchun Zhu, Xiang Li, Jintao He, Fei Di, Wei Liu, Lei Wang, Yongji Tian, Chunde Li, Jian Gong
OBJECTIVE: The survival rate and prognosis in infants with giant intracranial tumors is significantly worse than in older children. This study aimed to analyze the feasibility of delayed-operation for infants with giant intracranial benign tumor by evaluating the initial clinical presentations, expectant treatment measures, perioperative vital signs, and recuperation after surgery. PATIENTS AND DATA: We collected 3 infant patients aged 9.33 months (aged<1 year, ranged 5 to 12 months) on average with giant intracranial benign tumors during January 2015 and April 2016...
December 6, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27914325/fabrication-of-metronidazole-loaded-poly-%C3%AE%C2%B5-caprolactone-zein-core-shell-nanofiber-membranes-via-coaxial-electrospinning-for-guided-tissue-regeneration
#10
Min He, Huiyi Jiang, Rui Wang, Yi Xie, Changsheng Zhao
To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix...
November 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27903119/the-learning-curve-in-endoscopic-endonasal-resection-of-craniopharyngiomas
#11
Varun R Kshettry, Hyunwoo Do, Khaled Elshazly, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans
OBJECTIVE There is a paucity of literature regarding the learning curve associated with performing endoscopic endonasal cranial base surgery. The purpose of this study was to determine to what extent a learning curve might exist for endoscopic endonasal resection in cases of craniopharyngiomas. METHODS A retrospective review was performed for all endoscopic endonasal craniopharyngioma resections performed at Thomas Jefferson University from 2005 to 2015. To assess for a learning curve effect, patients were divided into an early cohort (2005-2009, n = 20) and a late cohort (2010-2015, n = 23)...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27903116/endoscopic-endonasal-versus-open-transcranial-resection-of-craniopharyngiomas-a-case-matched-single-institution-analysis
#12
Nelson Moussazadeh, Vishaal Prabhu, Evan D Bander, Ryan C Cusic, Apostolos John Tsiouris, Vijay K Anand, Theodore H Schwartz
OBJECTIVE The authors compared clinical and radiological outcomes after resection of midline craniopharyngiomas via an endoscopic endonasal approach (EEA) versus an open transcranial approach (TCA) at a single institution in a series in which the tumors were selected to be equally amenable to gross-total resection (GTR) with either approach. METHODS A single-institution retrospective review of previously untreated adult midline craniopharyngiomas was performed. Lesions were evaluated by 4 neurosurgeons blinded to the actual approach used to identify cases that were equally amenable to GTR using either an EEA or TCA...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#13
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27867914/therapeutic-strategy-for-cavernous-sinus-invading-non-functioning-pituitary-adenomas-based-on-the-modified-knosp-grading-system
#14
Juyoung Hwang, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Min Ho Lee, Doo-Sik Kong
BACKGROUND: Non-functioning pituitary adenomas (NFPA) invading into the cavernous sinus are surgically challenging. To decrease recurrence rate, surgeon makes a strong endeavor to resect tumor gross totally. However, gross total resection (GTR) is difficult to achieve with cavernous sinus invasion. Recently, a new classification system for cavernous invasion of pituitary adenomas was suggested. The aim of this study is to validate this new classification system and to identify limitations and considerations in designing treatment strategies for patients with NFPA involving the cavernous sinus...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867912/central-neurocytoma-a-review-of-clinical-management-and-histopathologic-features
#15
REVIEW
Seung J Lee, Timothy T Bui, Cheng Hao Jacky Chen, Carlito Lagman, Lawrance K Chung, Sabrin Sidhu, David J Seo, William H Yong, Todd L Siegal, Minsu Kim, Isaac Yang
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27847570/parasellar-extension-grades-and-surgical-extent-in-endoscopic-endonasal-transsphenoidal-surgery-for-pituitary-adenomas-a-single-surgeon-s-consecutive-series-with-the-aspects-of-reliability-and-clinical-validity
#16
Sang-Hyo Lee, Jae-Sung Park, Song Lee, Sung-Won Kim, Yong-Kil Hong
OBJECTIVE: The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas. METHODS: From November 2008 to August 2015, of the 286 patients who underwent EETS by the senior author, 208 were pituitary adenoma cases (146 non-functioning pituitary adenomas, 10 adrenocorticotropic hormone-secreting adenomas, 31 growth hormone-secreting adenomas, 17 prolactin-secreting adenomas, and 4 thyroid-stimulating hormone-secreting adenomas; 23 microadenomas, 174 macroadenomas, and 11 giant adenomas)...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27842886/potential-of-electrospun-chitosan-fibers-as-a-surface-layer-in-functionally-graded-gtr-membrane-for-periodontal-regeneration
#17
Saad B Qasim, Shariq Najeeb, Robin M Delaine-Smith, Andrew Rawlinson, Ihtesham Ur Rehman
OBJECTIVE: The regeneration of periodontal tissues lost as a consequence of destructive periodontal disease remains a challenge for clinicians. Guided tissue regeneration (GTR) has emerged as the most widely practiced regenerative procedure. Aim of this study was to electrospin chitosan (CH) membranes with a low or high degree of fiber orientation and examines their suitability for use as a surface layer in GTR membranes, which can ease integration with the periodontal tissue by controlling the direction of cell growth...
November 11, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27826681/role-of-surgical-resection-in-recurrent-glioblastoma-prognostic-factors-and-outcome-evaluation-in-an-observational-study
#18
Federico Pessina, Pierina Navarria, Luca Cozzi, Stefano Tomatis, Marco Riva, Anna Maria Ascolese, Armando Santoro, Matteo Simonelli, Lorenzo Bello, Marta Scorsetti
The role of surgical resection in progressive or recurrent glioblastoma multiforme (GBM) lack of high level of evidence. The aim of this evaluation was to assess the role of surgical resection in relapsing GBM, in relation to the extent of surgical resection (EOR) and the amount of residual tumor volume (RTV). Among patients treated for newly diagnosed GBM between September 2008-December 2014, 64 patients with recurrent GBM were included in this retrospective evaluation. All patients underwent surgical resection followed by adjuvant treatments, chemotherapy and/or radiotherapy Results were evaluated in terms of local control (LC) rate, progression free survival (PFS) and patients overall survival (OS)...
November 8, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27816029/impact-of-timing-of-radiotherapy-in-patients-with-newly-diagnosed-glioblastoma
#19
David M Randolph, Emory R McTyre, Anna K Paulsson, Jordan A Holmes, William H Hinson, Glenn J Lesser, Roy Strowd, Hui-Wen Lo, Adrian W Laxton, Stephen B Tatter, Waldemar Debinski, Michael D Chan
OBJECTIVE: To further evaluate if a delay in the start of radiation therapy (RT) affects patient outcomes for glioblastoma (GBM). PATIENTS AND METHODS: From May 1999 to May 2010, a total of 161 patients underwent surgery followed by RT for GBM. We assessed overall survival (OS) and progression free survival (PFS), stratified by extent of surgical resection. Included in the analysis were genomic predictors of progression. RESULTS: Median time from surgery to start of RT was 20days for biopsy alone, 28days for subtotal resection (STR) and 28days for gross total resection (GTR)...
October 22, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27800213/the-influence-of-root-surface-distance-to-alveolar-bone-and-periodontal-ligament-on-periodontal-wound-healing
#20
Marco Montevecchi, Annapaola Parrilli, Milena Fini, Maria Rosaria Gatto, Aurelio Muttini, Luigi Checchi
PURPOSE: The purpose of this animal study was to perform a 3-dimensional micro-computed tomography (micro-CT) analysis in order to investigate the influence of root surface distance to the alveolar bone and the periodontal ligament on periodontal wound healing after a guided tissue regeneration (GTR) procedure. METHODS: Three adult Sus scrofa domesticus specimens were used. The study sample included 6 teeth, corresponding to 2 third mandibular incisors from each animal...
October 2016: Journal of Periodontal & Implant Science
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