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https://www.readbyqxmd.com/read/28527009/the-simpson-grading-in-meningioma-surgery-does-the-tumor-location-influence-the-prognostic-value
#1
Kira Marie Voß, Dorothee Cäcilia Spille, Cristina Sauerland, Eric Suero Molina, Caroline Brokinkel, Werner Paulus, Walter Stummer, Markus Holling, Astrid Jeibmann, Benjamin Brokinkel
In meningiomas, location-specific differences of the prognostic value of the Simpson classification are sparsely investigated but can influence strategy of surgery. We therefore compared the prognostic value of the Simpson classification in different tumor locations. Progression was compared with Simpson grade in 826 meningioma patients (median age 58 years, female:male ratio 2.4) in location-specific uni- and multivariate analyses. Simpson grade strongly correlated with tumor location (p < .001). Within a median follow-up of 50 months, recurrence was observed in 107 of 803 patients (13%)...
May 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28524795/long-term-risk-of-recurrence-and-regrowth-after-gross-total-and-subtotal-resection-of-sporadic-vestibular-schwannoma
#2
Hirofumi Nakatomi, Jeffrey T Jacob, Matthew L Carlson, Shota Tanaka, Minoru Tanaka, Nobuhito Saito, Christine M Lohse, Colin L W Driscoll, Michael J Link
OBJECTIVE The management of vestibular schwannoma (VS) remains controversial. One commonly cited advantage of microsurgery over other treatment modalities is that tumor removal provides the greatest chance of long-term cure. However, there are very few publications with long-term follow-up to support this assertion. The purpose of the current study is to report the very long-term risk of recurrence among a large historical cohort of patients who underwent microsurgical resection. METHODS The authors retrospectively reviewed the medical records of patients who had undergone primary microsurgical resection of unilateral VS via a retrosigmoid approach performed by a single neurosurgeon-neurotologist team between January 1980 and December 1999...
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28512039/fluorescein-guided-surgery-for-high-grade-glioma-resection-an-intraoperative-contrast-enhancer
#3
Giuseppe Catapano, Francesco Giovanni Sgulò, Vincenzo Seneca, Giovanni Lepore, Laura Columbano, Giuseppe di Nuzzo
BACKGROUND: Fluorescein sodium salt is widely used in medicine as fluorescein isothiocyanate and commonly named fluorescein (FL). This fluorophore has been used as a fluorescent tracer for many applications, especially in ophthalmic surgery. The initial use in neuro-oncologic field occurred in 1948 in order to control tumor resection margins. After a transient disuse, it has recently had a second spring with the development of dedicated filters for operating microscope, although it is still under evaluation in clinical use...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28502683/surgical-management-and-adverse-factors-for-recurrence-and-long-term-survival-in-hemangiopericytoma-patients
#4
Gui-Jun Zhang, Zhen Wu, Li-Wei Zhang, Da Li, Jun-Ting Zhang
OBJECTIVE: Intracranial hemangiopericytoma (HPC) is a rare tumour type with a high recurrence rate. This study analysed the adverse factors for recurrence and survival of HPC patients. METHODS: We retrospectively reviewed clinical data of 120 HPC patients (mean age: 42 years; including 60 males) that were surgically treated in our hospital from December 2008 to January 2016. RESULTS: The gross total resection (GTR) rate was 71.7%. Sixty-three patients received postoperative adjuvant radiotherapy (PRT)...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28498059/oligodendroglioma-resection-a-surveillance-epidemiology-and-end-results-seer-analysis
#5
Ali A Alattar, Michael G Brandel, Brian R Hirshman, Xuezhi Dong, Kate T Carroll, Mir Amaan Ali, Bob S Carter, Clark C Chen
OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma is generally believed to be more sensitive to chemotherapy than astrocytoma of comparable grades. In this study the authors compare the survival benefit of gross-total resection (GTR) in patients with oligodendroglioma relative to patients with astrocytoma. METHODS Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, the authors identified 2378 patients with WHO Grade II oligodendroglioma (O2 group) and 1028 patients with WHO Grade III oligodendroglioma (O3 group)...
May 12, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28488953/atypical-meningioma-referral-patterns-treatment-and-adherence-to-guidelines
#6
Majed Alghamdi, Haocheng Li, Ivo Olivotto, Jay Easaw, John Kelly, Robert Nordal, Gerald Lim
OBJECTIVE: To determine the referral rate to radiation oncologist (RO), use of postoperative radiotherapy (PORT) and the impact of a clinical practice guideline (CPG) on patients with atypical meningioma (AM). METHODS: A retrospective review of meningioma patients (n=526) treated between 2003 and 2013 was undertaken. Patients' characteristics, extent of surgical resection (EOR), RO referral, PORT, date and treatment of first recurrence were collected for all patients >18 years with a new diagnosis of AM after surgical resection (n=83)...
May 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28483912/an-in-vitro-torc1-kinase-assay-that-recapitulates-the-gtr-independent-glutamine-responsive-torc1-activation-mechanism-on-yeast-vacuoles
#7
Mirai Tanigawa, Tatsuya Maeda
Evolutionarily-conserved TOR complex 1 (TORC1) responds to nutrients, especially amino acids, to promote cell growth. In yeast Saccharomyces cerevisiae, various nitrogen sources activate TORC1 with different efficiencies although the mechanism remains elusive. Leucine, and perhaps other amino acids, was reported to activate TORC1 via the heterodimeric small GTPases Gtr1-Gtr2, the orthologs of the mammalian Rag GTPases. More recently, an alternative Gtr-independent TORC1 activation mechanism that may respond to glutamine was reported, although its molecular detail is not clear...
May 8, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28474968/additive-effect-of-plasma-rich-in-growth-factors-with-guided-tissue-regeneration-in-treatment-of-intrabony-defects-in-chronic-periodontitis-patients-a-split-mouth-randomized-controlled-clinical-trial
#8
Sheethalan Ravi, Sankari Malaiappan, Sheeja Varghese, N D Jayakumar, Gopinath Prakasam
BACKGROUND: Periodontal regeneration can be defined as the complete restoration of lost periodontal tissues to their original architecture and function. Variety of treatment modalities have been proposed to achieve it. Plasma rich in growth factors (PRGF) is a concentrated suspension of growth factors that promotes restoration of the lost periodontal tissues. The objective of the present study was to assess the effect of Plasma rich in growth factors (PRGF) associated with Guided Tissue regeneration (GTR) versus GTR only in the treatment of intrabony defects in chronic periodontitis patients...
May 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28460034/single-copy-genes-as-molecular-markers-for-phylogenomic-studies-in-seed-plants
#9
Zhen Li, Amanda R De La Torre, Lieven Sterck, Francisco M Cánovas, Concepción Avila, Irene Merino, José Antonio Cabezas, María Teresa Cervera, Pär K Ingvarsson, Yves Van de Peer
Phylogenetic relationships among seed plant taxa, especially within the gymnosperms, remain contested. In contrast to angiosperms, for which several genomic, transcriptomic and phylogenetic resources are available, there are few, if any, molecular markers that allow broad comparisons among gymnosperm species. With few gymnosperm genomes available, recently obtained transcriptomes in gymnosperms are a great addition to identifying single-copy gene families as molecular markers for phylogenomic analysis in seed plants...
May 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28450233/revisiting-adjuvant-radiotherapy-following-gross-total-resection-of-who-grade-ii-meningioma
#10
Christopher S Graffeo, Heather E Leeper, Avital Perry, Joon H Uhm, Daniel J Lachance, Paul D Brown, Daniel J Ma, Jamie J Van Gompel, Caterina Giannini, Derek R Johnson, Aditya Raghunathan
BACKGROUND: Atypical meningioma is a WHO grade II tumor, with intermediate prognosis and risk-of-recurrence. Optimal management following gross total resection (GTR) is controversial, with observation versus adjuvant radiotherapy (RT) contentiously debated. METHODS: Pathologic review was performed of all atypical meningiomas diagnosed at our institution from 1988-2011. Retrospective chart review documented patient demographics, extent of surgical resection, documented radiation therapy, PFS, and OS...
April 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28439777/survival-trends-of-oligodendroglial-tumor-patients-and-associated-clinical-practice-patterns-a-seer-based-analysis
#11
Michael G Brandel, Ali A Alattar, Brian R Hirshman, Xuezhi Dong, Kate T Carroll, Mir Amaan Ali, Bob S Carter, Clark C Chen
There is limited information on the management strategies and survival trends for oligodendroglioma patients. Here we used the Surveillance, Epidemiology and End Results (SEER, 1999-2012) database to analyze the historical trends of oligodendroglioma patient survival and correlate these trends to evolving clinical practice of radiation therapy (RT) use and surgical practice of gross total resection (GTR). We identified 2689 World Health Organization (WHO) grade II oligodendroglioma (abbreviated as O2) and 1191 WHO grade III oligodendroglioma (abbreviated as O3)...
April 24, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28433845/clinical-outcome-after-extended-endoscopic-endonasal-resection-of-craniopharyngiomas-two-institution-experience
#12
Hye Ran Park, Varun R Kshettry, Christopher J Farrell, Jae Meen Lee, Yong Hwy Kim, Tae Bin Won, Doo Hee Han, Hyunwoo Do, Gurston Nyguist, Marc Rosen, Dong Gyu Kim, James J Evans, Sun Ha Paek
BACKGROUND: The extended endoscopic endonasal approach (EEA) to the anterior cranial base is used for the resection of craniopharyngiomas. OBJECTIVE: We present clinical experience and outcomes utilizing EEA for craniopharyngiomas. METHODS: A total of 116 patients in two remote institutions were enrolled in this retrospective study. Surgical, endocrinological and ophthalmological outcomes were assessed. RESULTS: The mean follow-up was 35 months (range, 1-115)...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432585/patterns-of-care-and-treatment-outcomes-in-older-adults-with-low-grade-glioma-a-50-year-experience
#13
Ryan S Youland, David A Schomas, Paul D Brown, Ian F Parney, Nadia N I Laack
The purpose of this study was to identify changes in presentation, treatment and outcomes of older patients with low-grade glioma (LGG) over the past 50 years. 94 adults aged 55 or older upon diagnosis of a WHO grade II LGG at Mayo Clinic between 1960 and 2011 were included and grouped by those diagnosed before (group I: 1960-1989) and after (group II: 1990-2011) the routine use of post-operative MRI. Median follow-up was 11.4 years. Pathologic diagnoses included astrocytoma in 55%, mixed oligoastrocytoma in 18% and oligodendroglioma in 27%...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28432584/clinical-features-and-long-term-outcomes-of-pediatric-spinal-meningiomas
#14
Liang Wu, Chenlong Yang, Tie Liu, Jingyi Fang, Jun Yang, Yulun Xu
Pediatric spinal meningiomas are very rare. Most studies on pediatric spinal meningiomas are case reports with literature reviews. This study presented a surgical series of 14 pediatric patients with histologically proven sporadic spinal meningiomas, including 5 WHO grade II tumors. In this series, there were 9 male and 5 female patients with a mean age of 11.1 years. Seven tumors were located in the cervical spine, 5 in the thoracic spine, and 2 in the lumbar spine. Gross total resection (GTR) of the tumor with a well-demarcated dissection plane was achieved in 11 cases, subtotal resection was achieved in 2 cases, and partial resection was performed in 1 case...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28429237/atypical-and-anaplastic-meningioma-outcomes-in-a-population-based-study
#15
T Garzon-Muvdi, W Yang, M Lim, H Brem, J Huang
Atypical and anaplastic meningiomas (AAM) are aggressive tumors. This study is aimed at examining associations between patient and tumor-related factors and tumor-related death in patients with AAM. We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with diagnosis of AAM from 1973 to 2012 in the SEER database were included. Patients lacking clinical information were excluded. Multivariate analysis between patient and lesion characteristics, and AAM-related death was performed to adjust for confounding factors...
April 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28427986/prognostic-implications-of-extent-of-resection-in-glioblastoma-analysis-from-a-large-database
#16
Daniel M Trifiletti, Clayton Alonso, Surbhi Grover, Camilo E Fadul, Jason P Sheehan, Timothy N Showalter
OBJECTIVE: To analyze the predictors for and clinical impact of gross total resection (GTR) in patients with glioblastoma (GBM). METHODS AND MATERIALS: The National Cancer Database was queried for patients with GBM diagnosed from 2004-2013 with known survival and extent of resection. Patients were grouped based on extent of resection into biopsy alone, subtotal resection (STR), and GTR. Univariable and multivariable (MVA) analyses were performed to investigate factors associated with the likelihood of GTR and overall survival (OS) following diagnosis...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28424876/extent-of-surgical-resection-and-adjuvant-temozolomide-improves-survival-in-pediatric-gbm-a-single-center-experience
#17
Subhash Gupta, Supriya Mallick, Rony Benson, K P Haresh, Pramod Kumar Julka, Goura Kishor Rath
BACKGROUND: Pediatric glioblastoma (pGBM) is an uncommon entity. The importance of concurrent and adjuvant temozolomide is not known in this subset of patients. METHODS: We retrospectively analyzed our database between 2000 and 2015. All patients were treated with maximally safe surgical resection. This was followed by a uniform treatment schedule of post-operative radiation with concurrent daily temozolomide at 75 mg/m(2). Radiation dose was 60 Gy in 30 fractions planned by 3-dimensional conformal radiotherapy...
April 19, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28419878/effect-of-gross-total-resection-gtr-in-who-grade-ii-astrocytomas-a-seer-based-survival-analysis
#18
Alexander J Schupper, Brian R Hirshman, Kate T Carroll, Mir Amaan Ali, Bob S Carter, Clark C Chen
INTRODUCTION: We wished to compare the survival benefit associated with gross total resection (GTR) in World Health Organization (WHO) grade II astrocytomas (A2) to those of grade III (A3) and grade IV (glioblastoma) astrocytomas. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, we identified 4,113 A2 patients. Surgical resection was defined as GTR, subtotal resection (STR), or no resection. Kaplan-Meier and multivariate Cox proportional hazards analyses were used to assess survival with respect to extent of resection (EOR)...
April 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28409727/clival-chordomas-considerations-after-16-years-of-endoscopic-endonasal-surgery
#19
Matteo Zoli, Laura Milanese, Rocco Bonfatti, Marco Faustini-Fustini, Gianluca Marucci, Giovanni Tallini, Corrado Zenesini, Carmelo Sturiale, Giorgio Frank, Ernesto Pasquini, Diego Mazzatenta
OBJECTIVE In the past decade, the role of the endoscopic endonasal approach (EEA) has relevantly evolved for skull base tumors. In this study, the authors review their surgical experience with using an EEA in the treatment of clival chordomas, which are deep and infiltrative skull base lesions, and they highlight the advantages and limitations of this ventral approach. METHODS All consecutive cases of chordoma treated with an EEA between 1998 and 2015 at a single institution are included in this study. Preoperative assessment consisted of neuroimaging (MRI and CT with angiography sequences) and endocrinological, neurological, and ophthalmological evaluations, which were repeated 3 months after surgery and annually thereafter...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28403097/predictive-factors-for-surgical-outcome-in-anterior-clinoidal-meningiomas-analysis-of-59-consecutive-surgically-treated-cases
#20
Ju-Hwi Kim, Woo-Youl Jang, Tae-Young Jung, In-Young Kim, Kyung-Hwa Lee, Woo Dae Kang, Seul-Kee Kim, Kyung-Sub Moon, Shin Jung
Despite the advances in the microsurgical technique and anatomical understanding of the anterior and middle skull base, anterior clinoidal meningiomas are still challenging lesions to resect completely and safely due to their intimate relationship with vital neurovascular structures. We report predictive factors for tumor recurrence and postoperative complications based on surgical outcome of patients with anterior clinoidal meningiomas treated at our institution.Fifty-nine consecutive patients with anterior clinoidal meningioma who were surgically treated between March, 1993, and July, 2015, were reviewed retrospectively...
April 2017: Medicine (Baltimore)
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