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https://www.readbyqxmd.com/read/27903119/the-learning-curve-in-endoscopic-endonasal-resection-of-craniopharyngiomas
#1
Varun R Kshettry, Hyunwoo Do, Khaled Elshazly, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans
OBJECTIVE There is a paucity of literature regarding the learning curve associated with performing endoscopic endonasal cranial base surgery. The purpose of this study was to determine to what extent a learning curve might exist for endoscopic endonasal resection in cases of craniopharyngiomas. METHODS A retrospective review was performed for all endoscopic endonasal craniopharyngioma resections performed at Thomas Jefferson University from 2005 to 2015. To assess for a learning curve effect, patients were divided into an early cohort (2005-2009, n = 20) and a late cohort (2010-2015, n = 23)...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27903116/endoscopic-endonasal-versus-open-transcranial-resection-of-craniopharyngiomas-a-case-matched-single-institution-analysis
#2
Nelson Moussazadeh, Vishaal Prabhu, Evan D Bander, Ryan C Cusic, Apostolos John Tsiouris, Vijay K Anand, Theodore H Schwartz
OBJECTIVE The authors compared clinical and radiological outcomes after resection of midline craniopharyngiomas via an endoscopic endonasal approach (EEA) versus an open transcranial approach (TCA) at a single institution in a series in which the tumors were selected to be equally amenable to gross-total resection (GTR) with either approach. METHODS A single-institution retrospective review of previously untreated adult midline craniopharyngiomas was performed. Lesions were evaluated by 4 neurosurgeons blinded to the actual approach used to identify cases that were equally amenable to GTR using either an EEA or TCA...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#3
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
November 22, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27867914/therapeutic-strategy-for-cavernous-sinus-invading-non-functioning-pituitary-adenomas-based-on-the-modified-knosp-grading-system
#4
Juyoung Hwang, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Min Ho Lee, Doo-Sik Kong
BACKGROUND: Non-functioning pituitary adenomas (NFPA) invading into the cavernous sinus are surgically challenging. To decrease recurrence rate, surgeon makes a strong endeavor to resect tumor gross totally. However, gross total resection (GTR) is difficult to achieve with cavernous sinus invasion. Recently, a new classification system for cavernous invasion of pituitary adenomas was suggested. The aim of this study is to validate this new classification system and to identify limitations and considerations in designing treatment strategies for patients with NFPA involving the cavernous sinus...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867912/central-neurocytoma-a-review-of-clinical-management-and-histopathologic-features
#5
REVIEW
Seung J Lee, Timothy T Bui, Cheng Hao Jacky Chen, Carlito Lagman, Lawrance K Chung, Sabrin Sidhu, David J Seo, William H Yong, Todd L Siegal, Minsu Kim, Isaac Yang
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27847570/parasellar-extension-grades-and-surgical-extent-in-endoscopic-endonasal-transsphenoidal-surgery-for-pituitary-adenomas-a-single-surgeon-s-consecutive-series-with-the-aspects-of-reliability-and-clinical-validity
#6
Sang-Hyo Lee, Jae-Sung Park, Song Lee, Sung-Won Kim, Yong-Kil Hong
OBJECTIVE: The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas. METHODS: From November 2008 to August 2015, of the 286 patients who underwent EETS by the senior author, 208 were pituitary adenoma cases (146 non-functioning pituitary adenomas, 10 adrenocorticotropic hormone-secreting adenomas, 31 growth hormone-secreting adenomas, 17 prolactin-secreting adenomas, and 4 thyroid-stimulating hormone-secreting adenomas; 23 microadenomas, 174 macroadenomas, and 11 giant adenomas)...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27842886/potential-of-electrospun-chitosan-fibers-as-a-surface-layer-in-functionally-graded-gtr-membrane-for-periodontal-regeneration
#7
Saad B Qasim, Shariq Najeeb, Robin M Delaine-Smith, Andrew Rawlinson, Ihtesham Ur Rehman
OBJECTIVE: The regeneration of periodontal tissues lost as a consequence of destructive periodontal disease remains a challenge for clinicians. Guided tissue regeneration (GTR) has emerged as the most widely practiced regenerative procedure. Aim of this study was to electrospin chitosan (CH) membranes with a low or high degree of fiber orientation and examines their suitability for use as a surface layer in GTR membranes, which can ease integration with the periodontal tissue by controlling the direction of cell growth...
November 11, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27826681/role-of-surgical-resection-in-recurrent-glioblastoma-prognostic-factors-and-outcome-evaluation-in-an-observational-study
#8
Federico Pessina, Pierina Navarria, Luca Cozzi, Stefano Tomatis, Marco Riva, Anna Maria Ascolese, Armando Santoro, Matteo Simonelli, Lorenzo Bello, Marta Scorsetti
The role of surgical resection in progressive or recurrent glioblastoma multiforme (GBM) lack of high level of evidence. The aim of this evaluation was to assess the role of surgical resection in relapsing GBM, in relation to the extent of surgical resection (EOR) and the amount of residual tumor volume (RTV). Among patients treated for newly diagnosed GBM between September 2008-December 2014, 64 patients with recurrent GBM were included in this retrospective evaluation. All patients underwent surgical resection followed by adjuvant treatments, chemotherapy and/or radiotherapy Results were evaluated in terms of local control (LC) rate, progression free survival (PFS) and patients overall survival (OS)...
November 8, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27816029/impact-of-timing-of-radiotherapy-in-patients-with-newly-diagnosed-glioblastoma
#9
David M Randolph, Emory R McTyre, Anna K Paulsson, Jordan A Holmes, William H Hinson, Glenn J Lesser, Roy Strowd, Hui-Wen Lo, Adrian W Laxton, Stephen B Tatter, Waldemar Debinski, Michael D Chan
OBJECTIVE: To further evaluate if a delay in the start of radiation therapy (RT) affects patient outcomes for glioblastoma (GBM). PATIENTS AND METHODS: From May 1999 to May 2010, a total of 161 patients underwent surgery followed by RT for GBM. We assessed overall survival (OS) and progression free survival (PFS), stratified by extent of surgical resection. Included in the analysis were genomic predictors of progression. RESULTS: Median time from surgery to start of RT was 20days for biopsy alone, 28days for subtotal resection (STR) and 28days for gross total resection (GTR)...
October 22, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27800213/the-influence-of-root-surface-distance-to-alveolar-bone-and-periodontal-ligament-on-periodontal-wound-healing
#10
Marco Montevecchi, Annapaola Parrilli, Milena Fini, Maria Rosaria Gatto, Aurelio Muttini, Luigi Checchi
PURPOSE: The purpose of this animal study was to perform a 3-dimensional micro-computed tomography (micro-CT) analysis in order to investigate the influence of root surface distance to the alveolar bone and the periodontal ligament on periodontal wound healing after a guided tissue regeneration (GTR) procedure. METHODS: Three adult Sus scrofa domesticus specimens were used. The study sample included 6 teeth, corresponding to 2 third mandibular incisors from each animal...
October 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/27791707/intraoperative-magnetic-resonance-imaging-in-pediatric-neurosurgery-safety-and-utility
#11
Mario Giordano, Amir Samii, Anna C Lawson McLean, Helmut Bertalanffy, Rudolf Fahlbusch, Madjid Samii, Concezio Di Rocco
OBJECTIVE The use of high-field intraoperative MRI has been largely studied for the treatment of intracranial tumors in adult patients. In this study, the authors investigated the safety, advantages, and limitations of high-field iMRI for cranial neurosurgical procedures in pediatric patients, with particular attention to craniopharyngiomas and gliomas. METHODS The authors performed 82 surgical procedures in patients under 16 years of age (range 0.8-15 years) over an 8-year period (2007-2014) using iMRI. The population was divided into 3 groups based on the condition treated: sellar region tumors (Group 1), gliomas (Group 2), and other pathological entities (Group 3)...
October 28, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27791524/reoperative-endoscopic-endonasal-surgery-for-residual-or-recurrent-pituitary-adenomas
#12
Hazem M Negm, Rafid Al-Mahfoudh, Manish Pai, Harminder Singh, Salomon Cohen, Sivashanmugam Dhandapani, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Regrowth of the lesion after surgical removal of pituitary adenomas is uncommon unless subtotal resection was originally achieved in the first surgery. Treatment for recurrent tumor can involve surgery or radiotherapy. Locations of residual tumor may vary based on the original approach. The authors evaluated the specific sites of residual or recurrent tumor after different transsphenoidal approaches and describe the surgical outcome of endoscopic endonasal transsphenoidal reoperation. METHODS The authors analyzed a prospectively collected database of a consecutive series of patients who had undergone endoscopic endonasal surgeries for residual or recurrent pituitary adenomas after an original transsphenoidal microscopic or endoscopic surgery...
October 28, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27790579/pure-titanium-membrane-ultra-ti-%C3%A2-in-the-treatment-of-periodontal-osseous-defects-a-split-mouth-comparative-study
#13
Rashmi Khanna, Rajeev Khanna, Nilesh Dinesh Pardhe, Nancy Srivastava, Manas Bajpai, Shailendra Gupta
INTRODUCTION: Although many different types of Guided Tissue Regeneration (GTR) membranes (resorbable/non-resorbable, including titanium mesh) have been used in the field of Periodontics till now, but this is the first and only clinical study testing the effectiveness of an ultra thin pure Titanium Membrane (Ultra Ti) as a GTR membrane in infra-bony periodontal defects. AIM: To compare the efficacy of GTR in intra-bony defects with newly introduced non-resorbable barrier membrane, made of titanium called "Ultra-Ti (®) GTR Membrane" versus open flap debridement...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27782153/terahertz-reflectometry-imaging-for-low-and-high-grade-gliomas
#14
Young Bin Ji, Seung Jae Oh, Seok-Gu Kang, Jung Heo, Sang-Hoon Kim, Yuna Choi, Seungri Song, Hye Young Son, Se Hoon Kim, Ji Hyun Lee, Seung Joo Haam, Yong Min Huh, Jong Hee Chang, Chulmin Joo, Jin-Suck Suh
Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771478/comparison-of-the-surgical-outcome-of-pterional-and-frontotemporal-orbitozygomatic-approaches-and-determination-of-predictors-of-recurrence-for-sphenoid-wing-meningiomas
#15
Shyamal C Bir, Tanmoy Maiti, Subhas Konar, Anil Nanda
OBJECTIVE: The pterional/frontotemporal orbitozygomatic (FTOZ) approaches are the two widely used procedures for resection of sphenoid wing meningiomas. However, a comparison of outcomes and complications of these two approaches has not been well described yet. Here, we investigated the outcomes, complications and predictors of favorable outcomes of these two approaches. METHODS: Data of ninety consecutive cases with sphenoid wing meningiomas between 1995 and 2015 was reviewed retrospectively...
October 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27765986/first-report-of-the-spiral-nematode-rotylenchus-incultus-nematoda-hoplolaimidae-from-cultivated-olive-in-tunisia-with-additional-molecular-data-on-rotylenchus-eximius
#16
Ilhem Guesmi-Mzoughi, Antonio Archidona-Yuste, Carolina Cantalapiedra-Navarrete, Hajer Regaieg, Najet Horrigue-Raouani, Juan E Palomares-Rius, Pablo Castillo
Spiral nematode species of the genus Rotylenchus have been reported on olive (Olea europaea L.) in several Mediterranean countries (Castillo et al., 2010; Ali et al., 2014). Nematological surveys for plant-parasitic nematodes on olive trees were carried out in Tunisia between 2013 and 2014, and two nematode species of Rotylenchus were collected from the rhizosphere of olive cv. Chemlali in several localities of Tunisia (Tables 1,2 [Table: see text] [Table: see text] ). Twenty-two soil samples of 3 to 4 kg were collected with a shovel from the upper 50 cm of soil from arbitrarily chosen olive trees...
September 2016: Journal of Nematology
https://www.readbyqxmd.com/read/27748726/endoscopic-versus-microscopic-transsphenoidal-surgery-for-pituitary-tumors
#17
Huang Guo-Dong, Ji Tao, Yang Ji-Hu, Zheng Wen-Jian, Zhang Xie-Jun, Guo Jian, Li Zhen, Jiang Tai-Peng, Ding Jian-Jun, Gao Yong-Zhong, Liu Wenlan, Li Wei-Ping
BACKGROUND: To compare the clinical outcomes and complications of 247 pituitary tumor patients managed by endoscopic and microscopic approaches in our hospital. METHODS: The authors performed a retrospective review of 100 pituitary tumor patients treated by endoscopic endonasal transsphenoidal surgery (ETS) and 147 patients treated by microscopic transsphenoidal surgery (MTS) at our center from January 2007 to July 2014. The tumors were stratified by Knosp classification and modified Hardy classification, and tumor gross total resection (GTR)/remission rate, visual improvement rate, complications, operation time, intraoperative bleeding and length of hospital stay were compared between ETS and MTS...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27744084/intracranial-clear-cell-meningiomas-study-on-clinical-features-and-predictors-of-recurrence
#18
Hui Zhang, Li Ma, Yu-Bo Wang, Cheng Shu, Yong-An Huang, Lian-Qiang Dong, Gang-Ge Cheng
OBJECTIVE: Clear cell meningioma (CCM) is a rare histological subtype of meningioma which is classified as WHO grade II tumor. We conducted the present study to characterize clinical features of intracranial CCM and investigate the prognostic factors associated with surgical recurrence-free survival (RFS) of the patients. METHODS: PubMed and Embase were searched for case reports and series relevant to CCM. For each included study, relevant data were extracted, including patients' characteristics, pathology findings, therapeutic modality, and outcome...
October 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27721034/hcv-dispersal-patterns-among-intravenous-drug-users-idus-in-athens-metropolitan-area
#19
Eleni Papachristou, Aikaterini Tsagkovits, Assimina Zavitsanou, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: Most of the HCV transmission the recent years in Greece was among IDUs. Our aim was to estimate the prevalence of HCV genotypes and to investigate the patterns of HCV dispersal among IDUs in Athens using current state of the art molecular epidemiology methods. METHODS: HCV sequences were determined from 238 HIV-negative IDUs collected on the basis of the "ARISTOTLE" prevention program carried out in Athens between 2012 and 2013. Phylogenetic trees were inferred on HCV sequences isolated from IDUs in Athens for the most prevalent HCV clades (subtypes 1a and 3a)...
October 6, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27715437/aggressive-resection-at-the-infiltrative-margins-of-glioblastoma-facilitated-by-intraoperative-fluorescein-guidance
#20
Justin A Neira, Timothy H Ung, Jennifer S Sims, Hani R Malone, Daniel S Chow, Jorge L Samanamud, George J Zanazzi, Xiaotao Guo, Stephen G Bowden, Binsheng Zhao, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Peter Canoll, Randy S D'Amico, Jeffrey N Bruce
OBJECTIVE Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma (GBM). Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue, facilitating safe maximal resection of GBM. In this study, the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing (CE) regions, where this relationship has been established, and into the non-CE (NCE), diffusely infiltrated margins...
October 7, 2016: Journal of Neurosurgery
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